左甲状腺素钠对妊娠期合并甲状腺功能减退症患者甲状腺功能和母婴结局的影响

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (37 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To discuss the effect of Levothyroxine Sodium on thyroid function and maternal and neonatal outcomes in pregnant women with hypothyroidism.Methods A total of 86 pregnant women with hypothyroidism treated in our hospital from January 2018 to January 2020 were selected as subjects and were divided into study group (43 cases)and routine group (43 cases) according to random number table method.The routine group took the conventional living guidance; on the basis of the former, the study group took Levothyroxine Sodium.The changes of serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), vitamin B12 and homocysteine (Hcy) levels before and after treatment between the two groups were observed.The maternal and neonatal outcomes were analyzed.Results After treatment, TSH level in the study group was lower than that in the routine group, with statistically significant difference (P＜0.05).FT3 and FT4 levels after treatment in the study group were higher than those in the routine group, with statistically significant differences (P＜0.05).Vitamin B12 level in the study group after treatment was higher than that in the routine group, with statistically significant difference (P＜0.05).The total incidence of poor maternal and neonatal outcomes in the study group (2.33%) was lower than that in the routine group (16.28%), with statistically significant difference (P＜0.05).Conclusion Levothyroxine Sodium can improve the thyroid hormone levels, reduce the incidence of poor maternal and neonatal outcomes and play a role in the long-term fetal development.

Key words： Levothyroxine Sodium Hypothyroidism Pregnancy Thyroid function Maternal and neonatal outcomes

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	HONG Hai-man

Cite this article:

HONG Hai-man. Effect of Levothyroxine Sodium on thyroid function and maternal and neonatal outcomes in pregnant women with hypothyroidism[J]. 中国当代医药, 2020, 27(22): 131-133转137.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I22/131

[1]	谢晖，潘海娟，王纯冬.妊娠期甲状腺功能减退症合并子痫前期的临床分析[J].湖南师范大学学报（医学版），2019，16（5）：84-86.
[2]	李进，张丽梅，于宁.妊娠期亚临床甲状腺功能减退症对妊娠结局及围产儿的影响及甲状腺激素替代治疗效果观察[J].中国计划生育学杂志，2019，27（1）：91-94.
[3]	黄家斌，李志辉，张琼，等.左甲状腺素钠片治疗妊娠期亚临床甲状腺功能减退症孕妇的疗效及对妊娠结局的影响[J].西部医学，2019，31（6）：913-916，921.
[4]	俞琳，蒋艳敏，钱丽.TGAb、TRAb、TMAb 与TPOAb 联合检测在妊娠期甲状腺功能减退症中的诊断作用[J].现代医学，2018，46（8）：867-870.
[5]	王艳芳，尤丽，马俊莲，等.妊娠期合并亚临床甲状腺功能减退症患者的TSH、FT3、FT4 水平与血压变异性及妊娠结局相关性分析[J].中国计划生育学杂志，2019，27（2）：226-229.
[6]	王春芳，周琼洁，徐焕，等.药物治疗对妊娠期甲状腺自身抗体阴性的亚临床甲状腺功能减退症孕妇的母儿预后影响[J].中国优生与遗传杂志，2017，25（11）：79-81，85.
[7]	向丽华，郭铭建，谢屹.硒酵母联合左甲状腺素钠治疗甲状腺功能减退的疗效分析[J].广西医科大学学报，2019，36（10）：1634-1638.
[8]	胡瑜.左旋甲状腺素片治疗亚临床甲状腺功能减退孕妇的剂量分析[J].山西医药杂志，2019，48（12）：1480-1482.
[9]	王瑞玲，朱红芳，张慧.左甲状腺素钠片治疗妊娠期甲状腺功能减退症对甲状腺功能及妊娠结局的影响[J].疑难病杂志，2016，15（4）：398-400，404.
[10]	游正铭.妊娠期亚甲状腺功能减退症患者血清叶酸维生素B12 和同型半胱氨酸水平的相关性分析[J].浙江临床医学，2017，19（6）：1102-1104.
[11]	冯潇宇，张瑞，陶新梅.甲状腺素替代疗法对妊娠期亚临床甲状腺功能减退孕妇妊娠结局的影响[J].广西医学，2019，41（8）：978-980，988.
[12]	刘妍，刘颖，俊梅，等.妊娠并发亚临床甲状腺功能减退症的影响因素及对妊娠结局的影响[J].中国妇幼保健，2017，32（12）：2553-2556.
[13]	吴跃跃，陈琳，黄新梅，等.妊娠期亚临床甲状腺功能减退的临床分析及甲状腺激素替代治疗的效果观察[J].中华内分泌代谢杂志，2017，33（3）：198-202.
[14]	雷晓静，韩克，陈茂林，等.左旋甲状腺素早期干预对亚临床甲状腺功能减退症孕妇妊娠结局影响[J].现代仪器与医疗，2018，24（4）：76-78.
[15]	柴丽娅，刘立立，佟玉，等.左旋甲状腺素片治疗孕早期合并亚临床甲状腺功能减退对妊娠结局的影响[J].中国妇幼保健，2018，33（21）：4866-4869.