低剂量米力农治疗≥80岁慢性心力衰竭患者的效果

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Abstract Objective To observe the effect of low-dose Milrinone in the treatment of chronic heart failure (CHF) patients over 80 years old.Methods A total of 60 patients over 80 years old with CHF were selected and divided into the treatment group and the control group by random number table method, 30 cases in each group.The treatment group was treated with standard treatment combined with low-dose Milrinone, and the control group was treated with standard treatment.The total effective rate, blood pressure, heart rate, left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular end systolic volume(LVESV), left ventricular end diastolic volume (LVEDV) and 6-minute walking test distance were compared between the two groups.Results The total effective rate was 86.7% in the treatment group, which was significantly higher than that in the control group (53.3%), the difference was statistically significant (P＜0.01).The LVEF ([57.2±9.3]%) and 6-minute walking test distance [(499.5±50.2) m] in the treatment group were higher than those in the control group([45.7±8.8]% and [392.5±90.8] m), the differences were statistically significant (P＜0.01).The LVESV ([116.3±52.7]ml),LVEDV ([192.6±45.4] ml) and LVESD ([47.4±6.3] mm) in the treatment group were lower than those in the control group ([126.2±41.5] ml, [201.9±50.2] ml and [50.2±8.6] mm), with statistical significances (P＜0.05).The LVEDD in the treatment group was (60.6±10.1) mm, which in the control group was (61.2±10.8) mm, with no statistical significance(P＞0.05).The LVEF ([57.2±9.3]%), 6-minute walking test distance ([499.5±50.2] m) in the treatment group after treatment were higher than those before treatment ([37.3±11.4]%, [246.6±72.2] m), the differences were statistically significant (P＜0.01).The LVESD, LVEDD, LVEDV and LVESV in the treatment group after treatment were lower than those before treatment, the differences were statistically significant (P＜0.05).The LVEF and 6-minute walking test distance of the control group after treatment were higher than those before treatment, the differences were statistically significant(P＜0.05).There were no significant differences in LVESV, LVEDV, LVESD and LVEDD between the control group before and after treatment (P＞0.05).There were no significant differences in blood pressure and heart rate between the two groups before and after treatment (P＞0.05).Conclusion The low-dose Milrinone can significantly improve heart function and exercise tolerance in elderly patients over 80 years old.

Key words： Chronic heart failure Milrinone Elderly 6-minute walking test Ultrasound Clinical efficacy

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	TANG Ai
	YANG Gui-zhi

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TANG Ai,YANG Gui-zhi. Effect of low-dose Milrinone in the treatment of chronic heart failure patients over 80 years old[J]. 中国当代医药, 2020, 27(22): 69-72.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I22/69

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