术后小剂量匀速输注右美托咪定对静脉自控镇痛效果及患者胃肠功能恢复的影响

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Abstract Objective To explore the influence of low-dose constant-rate infusion of Dexmedetomidine after surgery on the effect of patient-controlled intravenous analgesia (PCIA) and recovery of gastrointestinal function.Methods A total of 60 cases of gynecological patients who underwent laparoscopic surgery from January to October in 2019 in Yue Bei People′s Hospital were selected as the research objects, and were divided into group S (sufentanil group) and group D(dexmedetomidine group) according to the random double-blind method, 30 cases in each group.While the analgesic pump was turned on, group D was given a small dose of Dexmedetomidine by intravenous infusion at a constant rate,and group S was given an equal amount of saline at a constant rate.Vital signs, pain digital score (NRS) scores at four time points of 4, 8, 12, and 24 hours postoperatively, the number of analgesic pump compressions within 48 hours, the amount of Sufentanil, and recovery of gastrointestinal function time and occurrence of other adverse reactions were compared between the two groups of patients.Results The NRS scores of patients in group D were lower than those in group S at 4, 8, 12, and 24 hours after surgery, and the differences were statistically significant (P＜0.05).The number of intravenously controlled analgesic compressions and the total amount of Sufentanil in group D were less than those in group S within 2 days after surgery, and the recovery time of gastrointestinal function was shorter than that in group S,the differences were statistically significant (P＜0.05).The incidence of nausea and vomiting in group D was lower than that in group S, the difference was statistically significant (P＜0.05).Conclusion The low-dose constant-rate infusion of Dexmedetomidine after surgery can reduce the dose of intravenous self-controlled analgesic drugs, shorten the recovery time of gastrointestinal function, and reduce the incidence of nausea and vomiting in patients undergoing gynecological laparotomy.It is worthy of clinical promotion.

Key words： Dexmedetomidine Sufentanil Patient-controlled intravenous analgesia Recovery of gastrointestinal function

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	Articles by authors
	YANG Hai-hui
	WANG Bing
	LI Chang-ke
	HUANG Huan-sen

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YANG Hai-hui,WANG Bing,LI Chang-ke, et al. Influence of low-dose constant-rate infusion of Dexmedetomidine after surgery on the effect of patient-controlled intravenous analgesia and recovery of gastrointestinal function[J]. 中国当代医药, 2020, 27(22): 147-149转153.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I22/147

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