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2018 Vol. 25, No. 26
Published: 2018-09-18
4
Study the diagnostic value of 3.0T magnetic resonance enterography in patients with active small bowel Crohn disease
DONG Li-wei;ZHUANG Xiao-zhao;WANG Fei;ZHAO Ying-man;LI Jian-jun;HE Zhou-tao;CHEN Yi-yao;LAN Cheng
Objective
To explore the diagnostic value of 3.0T magnetic resonance enterography (MRE)technology for active small bowel Crohn disease(CD).
Methods
A total of 23 inpatients suspected with active small bowel CD treated in Hainan People′s Hospital from January 2015 to January 2017 were given 3.0T MRE,Imaging features and signal characteristics of small bowel lesions scanned in different phases were analyzed.The results of pathological examination by enteroscopy were the gold standard,the sensitivity and specificity of the scanning method in diagnosing small bowel CD were analyzed.
Results
The MRI image features of small intestinal CD lesions were multiple segmental thickening and abnormal enhancement of intestinal wall,morphological fixation,signal elevation and heterogeneity,comb sign,intestinal stenosis or dilatation.There was no significant difference in signal intensity of small intestinal lesions in different phases,intestinal wall and lumen changes between plain scan and enhancement(P>0.05).The sensitivity of MRE in diagnosing small bowel CD was 100%,the specificity was 83.33%.The accuracy rate of MRE in diagnosis of small bowel CD was 95.65%,and there was no significant difference between MRE and enteroscopy (P>0.05).
Conclusion
The small bowel CD lesions have characteristic changes under MRE scanning.MRE can improve the accuracy rate of judging small intestinal CD,and the specificity needs to be further improved.
2018 Vol. 25 (26): 4-07 [
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129
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8
Evaluation of anti-inflammatory activity of different polar parts of Portulaca oleracea L.
CHEN Xin-jiang;XIA Jia-yin
Objective
To compare the anti-inflammatory activity of different polar parts(water,ethanol,n-butyl alcohol,ethyl acetate,petroleum ether)extracts of Portulaca oleracea L..
Methods
Different polar parts extracts of Portulaca oleracea L.acted on mouse macrophage RAW264.7 cultured in vitro.MTT method was used to determine the cell vitality of the different extracts and Griess kit was used to measure the level of nitric oxide(NO)secreted by cells.
Results
Extracts of purslane water,n-butyl alcohol,ethyl acetate and petroleum ether could promote the proliferation of RAW264.7 macrophages.Extracts of ethanol,n-butanol,ethyl acetate,and petroleum ether could prevent macrophages induced by LPS from secreting NO.
Conclusion
Extracts of purslane ethanol,n-butanol,ethyl acetate and petroleum ether have potential anti-inflammatory activity.
2018 Vol. 25 (26): 8-12 [
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157
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13
Pharmacokinetic study of columbin from Radix Tinosporae in rabbits in vivo
ZENG Hao-tao
Objective
To study the pharmacokinetics of columbin from R adix Tinosporae in rabbits in vivo.
Methods
The columbin was extracted from the dried root of R adix Tinosporae,and the UPLC method for the determination of columbin was established.Chromatographic conditions,column:Acquity UPLC
R
BEN C
18
(2.1×100 mm,1.7 μm);mobile phase:0.3%phosphoric acid solution-acetonitrile(65:35);flow rate:1 ml/min;detection wavelength:225 nm;temperature:35°C.The specificity,linearity,quantitative limits,extraction recovery,precision and stability of the method were investigated.The peak area of the standard solution of different concentrations of culumbin was determined,and used to make the standard curve of the concentration of culumbin.The culumbin (50 mg/kg)was gavaged to rabbits,and limbic vein blood collection was conducted at 0,15,30,60,120,180,240,360,480 and 1400 min after administration.The blood concentration-time curve was drawn,and the corresponding pharmacokinetic parameters of culumbin in rabbits were calculated by using WinNonlin 3.3 software.
Results
Peak shape of the chromatogram showed that the retention time of culumbin was 16 min,with normal peak shape distribution.It was well separated from other peaks,and there was no endogenous material interference.The standard curve equation of culumbin concentration was Y=502967X+0.1501,the correlation coefficient r=0.995,the linear range was 0.00122-2.50000 nmol/L,and the minimum quantitative limit was 1.22×10
-3
nmol/L.The recovery rate of the plasma solution of culumbin at the mass concentration of 9.77,156.25 and 1250.00 nmol/L was over 80.0%,the average recovery rate was 84.2%,and the relative standard deviation (RSD)=3.1%.The RSD between two days of the 156.25 nmol/L culumbin plasma solution was 3.5%,the first day RSD was 1.7%,the second day RSD was 4.6%.Preserved 24 h at room temperature,repeated freezing,thawing 3 times,and-20℃cryopreservation 14 d average recovery was 90.0%-110.0%.Pharmacokinetic parameters:T
max
=68.9 min,peak concentration(C
max
)=0.0671 nmol/L,terminal elimination half-life(T
1/2
)=438.67 min,medication in the area under the curve(AUC)=81.49,end eliminate rate(K
e
)=0.0017,clearance(CL)=20132.72,bioavailability(F)=14.08%.
Conclusion
The UPLC method was used to determine the concentration of columbin,and its specificity,extraction recovery and stability all meet the requirements,which is suitable for the systematic study of the pharmacokinetics of columbin in rabbits.
2018 Vol. 25 (26): 13-17 [
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18
Analysis the clinical characteristics of thyroid nodules with different nature
LI Ya-qing;ZHANG Jia-jun
Objective
To explore the clinical characteristics of thyroid nodules with different nature in order to better evaluate the nature of thyroid nodules.
Methods
The data of 508 inpatients with surgical removal of thyroid nodules in our hospital from January to October,2013 were investigated,according to the pathological diagnosis,they were divided into benign group and malignant group.The gender,serum TSH level and ultrasonographic data were compared between the two groups.
Results
①There were 508 patients with thyroid nodules,396 cases were benign patients,the average age was(46.26±12.25)years old,112 cases were malignant patients,the average age was(42.28±13.12)years old,and there was no significant difference in the average age between the two groups(P>0.05).In benign group (n=362),nodular goiter was the most common,accounting for 91.4%,while in malignant group (n=87),papillary carcinoma was the most common,accounting for 77.7%.The average age of patients with subacute thyroiditis was the smallest,and there was no significant difference in the mean age of other pathological types(P>0.05).The prevalence of thyroid nodules in women was higher than that in men (80.3%vs.19.7%)(P<0.05),and there was no significant difference between the two groups(P=0.798).②The serum thyroid stimulating hormone(TSH)level in malignant group was higher than that in benign group,but the difference was not statistically significant(P=0.891).③Comparing the thyroid ultrasonographic data of the two groups,the malignant group had more single,no cystic change,unclear boundary,low echo-level,solid nodules or solid+mixed nodules,fine calcification,cervical lymph node enlargement,and abundant blood supply in and around the cervical lymph nodes(P<0.01).
Conclusion
Thyroid nodules are mainly benign and it is frequently seen in women,high TSH and ultrasonography suggest that single,no cystic change,unclear boundary,low echo-level,solid nodules or solid+mixed nodules,fine calcification,cervical lymph node enlargement,and abundant blood supply in and around the cervical lymph nodes are more likely to be malignant nodules.
2018 Vol. 25 (26): 18-21 [
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22
Effect comparison of different surgical methods treating adrenal tumor
ZHU Chen-hui;HUANG Hai-wen; YANG Shui-hua;GAO Shao-qing;XU Jian-bin;CAI Zhi-ren
Objective
To compare the clinical effect of the different surgical methods treating adrenal tumor.
Methods
A total of 185 patients with adrenal tumor treated in our hospital From January 2008 to January 2018 were selected as objects,and they were divided into group A(62 cases),group B(62 cases)and group C(61 cases)according to the different surgical methods.Patients in group A,B and C received retroperitoneal laparoscopic surgery,transabdominal laparoscopic surgery and open surgery respectively.The operative time,intraoperative bleeding volume,postoperative ambulation time,postoperative hospitalization time,postoperative intestinal function recovery time,VAS pain score,the incidence of postoperative complications,blood transfusion rate,satisfaction degree of patients and the rate of converting to open surgery during operation were compared among the three groups.
Results
The intraoperative bleeding volume of group A and group B were significantly less than that of group C (P<0.05),but there was no significant difference between group A and group B(P>0.05).The operative time,postoperative ambulation time,postoperative hospitalization time,postoperative intestinal function recovery time were significantly shorter than those in group B and group C,VAS pain score in group A was significantly lower than that in group B and group C (P<0.001).The incidence of postoperative complications and blood transfusion rate in group A and group B were significantly lower than those in group C(P<0.0167).The satisfaction rate of patients in group A was significantly higher than that in group B and C(P<0.05),and there was no significant difference in the rate of converting to open surgery during operation between group A and group B(P>0.05).
Conclusion
Retroperitoneal laparoscopic surgery treating adrenal tumor has the advantages of small incision,less bleeding,quick recovery,light pain,low blood transfusion rate and fewer complications.It can also improve the satisfaction and comfort of patients.It is worthy of clinical promotion and application.
2018 Vol. 25 (26): 22-26 [
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Research progress of AMP-activated protein kinase in renal fibrosis
LIU Hui-ming;WANG Yuan-yuan;GUO Bing
Adenylate-activated protein kinase (AMPK)is an important energy-sensing regulator in the body,and is widely present in eukaryotes.AMPK can not only regulate energy metabolism,but also promote autophagy,induce apoptosis,regulate oxidative stress and anti-inflammatory effects.More and more studies have found that AMPK can prevent renal fibrosis by regulating oxidative stress and inhibiting multiple fibrotic signaling pathways.Therefore,AMPK is expected to become a new method for the prevention and treatment of kidney fibrosis.AMPK and its related mechanisms for inhibiting renal fibrosis will provide new targets and basis for clinical prevention and treatment of renal fibrosis.This article gives a brief review of the relationship between AMPK and kidney fibrosis.
2018 Vol. 25 (26): 27-30 [
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133
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31
Study progress of blood transfusion therapy for severe β-thalassaemia major
WEI Hai-chun;ZHENG Min
Thalassemia is a serious public health problem in the world.In China,Guangdong and Guangxi are regions of high incidence.Severe β-thalassemia is an ineffective hematopoietic or hemolytic anemia resulting from the accumulation of α -globin chain imbalance caused by the decrease or absence of β -globin production,which is a serious fatal disease.From 3 to 6 months after birth,the patient began to develop chronic progressive hemolysis,accompanied by developmental retardation,pale complexion,hepatosplenomegaly and other symptoms.As the condition worsens,bone swelling occurs.Without blood transfusion,the patientundefineds life span is as little as 5 years.Although the life span of the patients with severe β-thalassemia is significantly prolonged after regular blood transfusion,repeated blood transfusion resulted in hypothyroidism,diabetes mellitus and hyposexual function due to iron overload.Standard ironremoving therapy can lighten the iron load of patients,but long-term iron removal seriously affects the quality of life of patients,so compliance is poor.In recent years,hematopoietic stem cell transplantation (HSCT)is the only medical method to cure severe β-thalassemia.The life quality of patients with thalassemia after stem cell transplantation is significantly higher than that of patients treated with traditional blood transfusion and iron removal,but there are still problems of life-threatening complications and high cost of treatment after transplantation.
2018 Vol. 25 (26): 31-35 [
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Research progress in inhibiting neovascularization of lung cancer and its clinical application
ZHANG Rui-lian;ZHANG Qing
Angiogenesis can seriously affect the occurrence and development of tumors.In recent years,with the development of molecular biology,targeting angiogenesis has become a research hotspot for the treatment of non-small cell lung cancer(NSCLC).Blocking the blood supply of tumor cells,making the cells in a state of hypoxia and lack of nutrients,is an effective means to inhibit the growth and proliferation of tumors.Targeting tumor angiogenesis as a target has become a research hotspot,however,the Angiogenesis is extremely complex,and single target blocking therapy often does not solve the underlying problem.Future anti-vascular therapies will focus on multi-target combined blockade.This article reviews the role of several regulatory factors related to tumor angiogenesis and their clinical applications,aiming to provide a reference for the clinical research of lung cancer.
2018 Vol. 25 (26): 36-38 [
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161
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39
Study progress in the treatment of diabetic foot with transverse tibial bone movement
SUN Zhen;WANG Tao;ZHANG Qi-fu
The application of lateral tibial bone transfer in the treatment of diabetic foot is not long,and the biological mechanism of lateral tibial bone transfer in promoting wound healing of diabetic foot ulcer is still unclear,and there is no consensus on the treatment standard.The biological mechanism of lateral tibial bone transfer in the treatment of diabetic foot can be summarized as follows.Using the tension-stress rule of ilizarov technique to promote vascular reconstruction and tissue regeneration.Stimulating bone marrow stem cells and the SDF-1-CXCR4 axis.The expression of SDF-1a and the regeneration of wound were induced by EMT.The treatment of diabetic foot with lateral tibial bone transfer has been widely accepted in clinic.Domestic orthopedic doctors are still not familiar with the systematic treatment scheme to promote the wound healing of diabetic foot by tibial lateral bone transfer.At present,it is believed that the treatment of diabetic foot with lateral tibial bone transfer should follow the combination of internal and surgical treatment,and the size of bone window and the length of moving time still need a large number of animal and clinical experiments.This article reviews the principle and clinical study of lateral tibial bone transfer in the treatment of diabetic foot.
2018 Vol. 25 (26): 39-41 [
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213
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42
Clinical application progress of fractional flow reserve
YE Cheng-lin;XIAO Jian-ming
The morbidity of coronary atherosclerotic heart disease in China is increasing year by year,resulting in high mortality and serious harm.With the continuous development of coronary artery interventional therapy,techniques such as intravascular ultrasound (IVUS),optical coherence tomography (OCT),and fractional flow reserve (FFR)emerge.Coronary angiography(CAG)is considered as “gold standard” for the diagnosis and treatment of coronary heart disease.To address whether the diseased coronary arteries leading to myocardial ischemia,FFR guided percutaneous coronary intervention (PCI)for revascularization has become a research hotspot,which is constantly being applied in clinical practice.The article is going to review the current clinical application of FFR.
2018 Vol. 25 (26): 42-45 [
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152
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46
Clinical research status of diabetes in pregnancy
LIU Gui-ping;ZHANG Lin;ZHANG Guo-ling
Diabetes in pregnancy including pre-gestational diabetes mellitus(PGDM)and gestational diabetes mellitus(GDM)is an important disease which can lead to many adverse pregnancy outcomes.In recent years,the prevalence rate continues to rise,which is attracting more and more attention.Studies have shown that microbes are closely related to the metabolic diseases of pregnancy.The influence of gestation hyperglycemia on maternal body is abnormal glucose metabolism,cardiovascular disease,metabolic syndrome,and postpartum depression.The influence of the offspring is manifested by fetal death,malformation and other adverse pregnancy outcomes as well as the long-term occurrence of abnormal glucose metabolism and obesity.Early diagnosis of GDM has important clinical significance.Blood glucose management should run through the whole course of pre-pregnancy,pregnancy and postpartum.Good blood glucose control can improve the near and long term prognosis of mother and infant.Lifestyle intervention is the basic strategy of blood glucose management.Insulin is the first choice for drug treatment.The selection of basic insulin,which accords with the physiological secretion characteristics,is optimized treatment strategy.In this paper,the relevant research status at home and abroad is reviewed,in order to provide useful reference for clinical diagnosis and treatment.
2018 Vol. 25 (26): 46-49 [
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146
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Influence of body mass index and abdominal circumference index on the location and etiology of acute ischemic stroke
LIU Si-ping;YUAN Kun-xiong
Objective
To investigate the influence of body mass index(BMI)and abdominal circumference index on the location and etiology of ischemic stroke.
Methods
A total of 80 patients with acute ischemic stroke(CIS)who were admitted to our hospital from January 2016 to September 2017 were selected as the observation group.80 patients with physical examination who were examined in our hospital during the same period were selected as the control group.The body height,weight,and abdominal circumference of the two groups were calculated,and the BMI and abdominal circumference index were calculated and the Oxfordshire Community Stroke Project(OCSP)classification and TOAST classification were performed.
Results
The BMI of the overweight and obesity subgroup and the abdominal circumference index of the abdominal circumference abnormal subgroup were higher in the observation group than in the control group(P＜0.05）;PACI in the OCSP subtype of patients with different BMI subgroups.The proportion of type(41.25%)was higher than that of TACI type(6.25%),LACI type(30.00%),POCI type (22.5%),the difference was statistically significant(P<0.05）;OCSP classification in patients with different abdominal circumference index subgroups.In the subgroups of≤1 cm/kg,the POCI type ratio was lower than ＞1 cm/kg， with a statistically significant difference (P<0.05）;According to the TOAST classification,there were 25 cases(31.25%)of LAA type and 27 cases (33.75%)SAO type,13 cases(16.25%)CE type,7 cases(8.75%)SOE type and 9 cases(11.25%)SUE type.Among the TOAST subtypes with different BMI,only the proportion of SAO was lower than that of LAA,and the difference was statistically significant(P<0.05）.The subtypes with different abdominal circumference index were subtypes of ＞1 cm/kg subtype LAA.Subgroups above≤1 cm/kg were statistically significant(P<0.05）,while subtypes＞1 cm/kg subgroup were less than ≤1 cm/kg subgroup,with a statistically significant difference (P<0.05）.
Conclusion
The BMI and abdominal circumference index of patients with CIS can affect the location and etiology of ischemic stroke.It can be used as an important index to predict the etiology and pathogenesis.
2018 Vol. 25 (26): 50-53 [
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134
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Application value of serum PCT，CRP，WBC in assessing the condition and prognosis of patients with sepsis
XIE Shu-feng;QI Ying-jing;FENG Ming-tao;ZENG Guan-yin
Objective
To explore the value of serum procalcitonin(PCT),C-reactive protein(CRP)and white blood cell count(WBC)in the evaluation of the condition and prognosis of sepsis patients.
Methods
One hundred and sixteen patients with sepsis admitted to our hospital from January 2016 to December 2017 were selected.Among them,they were further divided into sepsis group(n=77),severe sepsis group(n=21),and septic shock group(n=18).The serum levels of PCT,CRP,and WBC,band the survival status of the patients after 2 weeks of hospitalization and the corresponding indexes in the three groups were observed and compared.The correlations between serum PCT and CRP,and PCT and WBC were analyzed.
Results
The levels of PCT,CRP and WBC in the three groups were significantly different(P＜0.01）.As the severity of sepsis increased,the levels of PCT,CRP,and WBC increased significantly(P＜0.01）.After 2-week treatment,83 patients improved their conditions,25 cases were invalid,and 8 cases died.The PCT,CRP,and WBC levels in the death cases were significantly higher than those in the invalid and improved cases.The PCT,CRP,and WBC levels in invalid cases were significantly higher than those in the improved cases(P＜0.01）.The Pearson correlation analysis showed that serum CRP and WBC were both positively correlated with PCT (r＞0,P＜0.01）,and the correlation between CRP and PCT was greater than that between WBC and PCT.
Conclusion
Serum PCT,CRP and WBC levels are all closely related to the severity of sepsis.The higher the levels,the more severe the patient′s condition is,and the worse the prognosis is.The evaluation level of CRP and PCT is better than that of WBC.
2018 Vol. 25 (26): 54-56 [
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Analysis of clinical features of patients with hyperlipidemia pancreatitis and biliary pancreatitis in Gannan Area
YE Yan-qing;ZENG Bin;XU Guo-feng;XIE Yun;LIAO Yue-guang
Objective
To compare the clinical features of patients with hyperlipidemia pancreatitis(HLAP)and patients with biliary pancreatitis(ABP)in Gannan Area,and improve the diagnosis and treatment of HLAP.
Methods
A retrospective analysis of 189 patients with AP from January 2013 to December 2016 in the First Affiliated Hospital of Gannan Medical College was performed.AP patients were divided into ABP group and HLAP group according to the etiology.The patients were divided into mild acute pancreatitis subgroup and moderately severe acute pancreatitis(MAP)or severe acute pancreatitis subgroup(MSAP+SAP)according to the severity classification.The differences of Demographic characteristics and biochemical indexes between two groups were compared.
Results
The average age of the ABP group was higher than that in the HLAP group,the difference was statistically significant(P<0.01）.The ratios of male and moderate or severe pancreatitis in HLAP group were more than that in the ABP group,the differences were statistically significant(P<0.01）.The level of TG,glucose and D-dimer in HLAP group were higher than those in the ABP group,the differences were statistically significant(P<0.01）.The plasma levels of AMS,ALT and bilirubin in ABP group were higher than those in the HLAP group,the differences were statistically significant(P<0.01）.
Conclusion
The hyperlipidemia pancreatitis mostly occur in lower age,and it more occur in male.The HLAP patients always more severe and easier develop to serve acute pancreatitis.
2018 Vol. 25 (26): 57-59 [
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127
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Comparison of clinical effect of mammato minimally invasive rotary drainage and traditional open incision and drainage in the treatment of lactation mammary abscess
ZENG Xiao-li
Objective
To investigate the clinical efficacy of mammato minimally invasive rotary drainage (MMT)and traditional open drainage in the treatment of breast abscess during lactation.
Methods
The 100 breast abscess patients who were treated in our hospital from June 2014 to June 2017 were divided into observation group and control group according to the different surgical methods,50 cases in each group.The patients in the observation group were operated by mammato minimally invasive circumflex drainage,and the patients in the control group were operated by traditional open incision and drainage.After the operation,the postoperative pain degree of the two groups and the postoperative recurrence rate was compared.
Results
Before operation,the VAS score of the observation group was(3.8±0.8)points,and the VAS score of the control group was(3.7±0.9)points.After operation the VAS score of the observation group was(2.4±0.5)points and the VAS score of the control group was(3.3±0.7)points.There was no significant difference in preoperative score between the two groups(P＞0.05）,and the postoperative VAS score was higher than that before the operation (P<0.05）;the VAS score of the observation group was significantly lower than that of the control group (P<0.05）;the recurrence rate of the observation group (6%)was significantly lower than that of the control group (22%),the difference was statistically significant(P<0.05）.
Conclusion
MMT can obviously reduce the pain of the patients,and the recurrence rate is low.It is worthy of clinical application.
2018 Vol. 25 (26): 60-62 [
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125
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The diagnostic value of dynamic electrocardiogram for patients with arrhythmia of coronary heart disease
CHEN Qi-fei
Objective
To observe the diagnostic value of dynamic electrocardiogram for patients with arrhythmia of coronary heart disease.
Methods
A total of 60 patients with coronary heart arrhythmia treated in our hospital from December 2016 to December 2017 were selected as the subjects,and divided into the control group and the observation group by the random digital table method,with 30 cases in each group.The control group received routine electrocardiogram diagnosis,while the observation group took the dynamic electrocardiogram diagnosis.The diagnostic value of the two groups were compared.
Results
The detection rates of ventricular arrhythmia,atrial arrhythmia,atrioventricular block and short needle supraventricular speed in the observation group were significantly higher than those in the control group,with a significant difference(P<0.05).The diagnostic total satisfaction of the observation group was 96.67%,which was significantly higher than that of the control group (76.67%),the difference was statistically significant(P<0.05).
Conclusion
Dynamic electrocardiogram monitoring for patients with arrhythmia of coronary heart disease can effectively monitor the time of arrhythmia and the condition of coronary ischemia,gives timely and effective intervention treatment,avoids the deterioration of the disease,has high value,and provides sufficient reference information for clinicians to diagnose and treat the disease.It has to be further promoted and adopted.
2018 Vol. 25 (26): 63-65 [
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132
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Effect of Dipeptidyl Peptidase-4 inhibitors combined with Acarbose on blood glucose control and body mass index of elderly patients with type 2 diabetes mellitus
LI Yi;CHANG Hai-ying
Objective
To investigate the clinical efficacy of dipeptidyl peptidase-4 inhibitors combined with acarbose in the treatment of elderly patients with type 2 diabetes mellitus （T2DM）.
Methods
A total of 108 cases of T2DM patients in our hospital from September 2015 to October 2017 were selected,and divided into the observation group and the control group according to the random number table method,with 54 cases in each group.On the basis of routine diet and exercise intervention,the control group was treated with acarbose,and the observation group was treated with acarbose+dipeptidyl peptidase-4 inhibitors (sitagliptin).Both groups were treated for 12 weeks.The blood glucose level[fasting blood glucose(FBG),postprandial 2 h blood glucose(2h PG),glycosylated hemoglobin(HbA1c)],body mass index (BMI)and incidence of adverse reactions during treatment were compared between the two groups before and after treatment.
Results
After treatment,the levels of FBG,2 h PG and HbA1c were lower than those before treatment in two groups(P<0.05),and the observation group was lower than the control group(P<0.05).After treatment,the BMI in the observation group was lower than that before the treatment(P<0.05),but there were no significant changes in the control group(P>0.05),and the BMI in the observation group was lower than that in the control group(P<0.05).There were no significant differences in the incidence of flatulence,diarrhea and nasopharyngitis in the observation group compared with the control group during the treatment(P>0.05).
Conclusion
Dipeptidyl peptidase-4 inhibitors combined with acarbose in the treatment of elderly T2DM is beneficial to the control of blood sugar and the decrease of BMI,and it has high safety.
2018 Vol. 25 (26): 66-68 [
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The efficacy and safety of Alogliptin combined with Metformin in the treatment of newly diagnosed type 2 diabetic patients
CAO Hong-bin
Objective
To summarize the efficacy of Alogliptin combined with Metformin in the treatment of newly diagnosed type 2 diabetes mellitus,and to evaluate the safety of its treatment.
Methods
A total of 78 newly diagnosed patients with type 2 diabetes from August 2016 to June 2017 were selected as the subjects,and divided into the control group(34 cases)and the observation group(44 cases)by double blind method.The control group was treated with metformin lowering glucose treatment,and the observation group was treated with Alogliptin combined with Metformin lowering glucose treatment.The effects of hypoglycemic of the two groups were compared.
Results
The improvement of fasting blood glucose,postprandial 2 h blood glucose level,glycated hemoglobin and fasting insulin after treatment in the observation group was better than before the treatment(P<0.05).The improvement of fasting blood glucose,postprandial 2 h blood glucose level,glycated hemoglobin and fasting insulin after treatment in the observation group was better than that of the control group after treatment,the difference was statistically significant(P<0.05).There was no significant difference in the rate of BMI,incidence of hypoglycemia and incidence of adverse reactions between the two groups(P>0.05).
Conclusion
Alogliptin combined with Metformin is effective and safe in the treatment of newly diagnosed type 2 diabetes.
2018 Vol. 25 (26): 69-71 [
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Comparison of efficacy of thoracoscope assisted esophageal cancer radical resection and open radical resection for esophageal cancer in elderly patients with esophageal cancer and the influence postoperative recovery
ZHAORI Ge-tu;ZHOU Ling-yun;SUN Zhi-gang
Objective
To compare the effect of thoracoscope assisted radical resection of esophageal carcinoma and open radical resection for esophageal cancer in elderly patients with esophageal cancer and the influence on postoperative recovery.
Methods
Eighty-five patients with esophageal cancer who were admitted to our hospital from March 2015 to February 2016 were selected as study subjects.They were divided into control group (n=42)and observation group (n=43)according to the odd/even number of the beds.In the control group,open radical resection was used,while in the observation group,thoracoscope assisted radical resection was adopted.The postoperative related complications,and deaths,recurrences,and metastases occurred within 2 years after surgery by outpatient follow-up were calculated.The differences in postoperative recovery,surgery and quality of life were compared between two different surgical procedures.
Results
There was no significant difference in recurrence,death and metastasis rate between the two groups (P>0.05).The incidence of complications in the observation group (9.3%)was lower than that in the control group(21.4%),the difference was statistically significant(P<0.05).The amount of bleeding in the observation group was less than that in the control group.The hospital stay and time of postoperative extubation were shorter in the observation group than in the control group,the difference was statistically significant(P<0.05).There was no significant difference in surgical time or amount of lymph node dissection between the two groups(P>0.05).The quality of life scores after treatment in the two groups were higher than that before treatment,and the quality of life score in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).
Conclusion
For esophageal cancer patients,thoracoscope assisted radical resection obtains a great prognosis effect with fast postoperative recovery,few complications and significant improvement of quality of life.
2018 Vol. 25 (26): 72-74转78 [
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75
Clinical effect of transcatheter arterial chemo-embolization treating primary hepatic carcinoma
ZENG Jing-ke;XU Zhi-hua;LAI Xiao-huan;YE Jian-min;WANG Shui-gen
Objective
To explore the clinical effect of transcatheter arterial chemo-embolization (TACE)treating primary hepatic carcinoma.
Methods
A total of 80 patients with primary hepatic carcinoma treated in Department of the Fifth People's Hospital of Ganzhou City from February 2014 to February 2017 were selected as the subject,and divided into control group and observation group according to the random number table method,with 40 cases each group.Patients took the conventional anti-neoplastic drugs and TACE,respectively.The clinical effect,survival rate,gross tumor volume and alpha fetoprotein (AFP)values were probed.
Results
The clinical effective rate in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).After 6 and 12 months of treatment,the survival rate in the observation group was higher than the control group,the difference was statistically significant(P<0.05).The gross tumor volume of the observation group was smaller than that of the control group,and AFP values was lower than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the adverse event rate between the two groups(P>0.05).
Conclusion
The TACE has an obvious effect in primary hepatic carcinoma patients,can greatly increase their survival rate.It is worthy of clinical promotion.
2018 Vol. 25 (26): 75-78 [
Abstract
] (
134
)
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35
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79
The analysis of 631 cases cervical cancer screening
LI Juan;LIU Yue-hong;Gu Ping;MA Xiao-ling
Objective
To investigate cervical cancer screening in Kunshan,and provide reference for better prevention and treatment of cervical cancer.
Methods
Analysized retrospectively the clinical datas of 631 women who received screening cervical cancer and breast cancer from July 1 to November 1 in 2017 in Kunshan Maternal and Child Care Institute.
Results
Of 631 cases,8 cases(1.3%)aged 30 ～35,64 cases(98.7%)aged 35 ～64.271 cases(43%)had never participated in screening cervical cancer before,360 cases (57%)had participated in cervical cancer screening.260 cases(41.2%)were normal,371 cases（58.8%)were abnormal,including 4 cases trichomonasvaginalis,19 cases vulvoaginalcandidasis,13 cases bacterial vaginosis,9 cases uterine fibroid,242 cases cervicitis,84 cases others.Thinprep cytology test(TCT)of 22 cases(3.5%)were abnormal,among them 17 cases were ASCUS,3 cases were LSIL,2 cases were HSIL.22 cases(3.5%)had histopathologic result,including 4 cases of cervical polyp,2 cases of cervicitis,8 cases found koilocytes,3 cases of low level lesions,4 cases of high level lesions,1 case of cervical invasive squamous cell carcinomas.With the increase of the classification level of TBS in TCT,the probability of pathological changes above the high grade lesions of cervical biopsy increased (P<0.05).The incidence of the high grade lesions of cervical in HPV-positive patients was higher than that of HPV-negative patients,the difference was statistically significant(P<0.05).
Conclusion
Cervical cancer screening is of great value for early detection of cervical cancer and precancerous lesions and identification of high-risk groups.
2018 Vol. 25 (26): 79-81 [
Abstract
] (
119
)
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24
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82
Impact analysis of re-delivery modes of scar uterus in full-term pregnancy on maternal and neonatal outcome in elderly puerperae
LIN Fang
Objective
To investigate the influence of re-delivery modes of scar uterus in full-term pregnancy on maternal and neonatal outcome in elderly puerperae.
Methods
From July 2015 to March 2017,122 elderly puerperae with scar uterus in full-term pregnancy who underwent a secondary delivery were randomly enrolled as study subjects.According to the maternal status,they were divided into control group(n=86)and experimental group(n=36).In the experimental group,maternal vaginal delivery was recommended,while in the control group,maternal cesarean section was performed.The amount of blooding 24 hour after delivery,puerperal infection rate,postpartum fever,labor time,hospital stay,hospitalization costs,and neonatal weight and neonatal Apgar score were observed.
Results
The amount of blooding within 24 hours after delivery in the experimental group was less than that in the controi group,postpartum fever was lower than that in the controi group,labor duration,hospital stay was shorter than that in the controi group,and hospitalization costs was lower than that in the controi group,the differences were statistically significant(P<0.05).The puerperal infection rate,neonatal weight,and Apgar score were not displayed significant differences between the two groups(P＞0.05).
Conclusion
When the antenatal indexes of scar uterine in full-term term pregnancy in elderly puerperae qualifying the conditions of vaginal delivery,the vaginal delivery mode should be preferred with available medical conditions.
2018 Vol. 25 (26): 82-84 [
Abstract
] (
147
)
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24
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85
Clinical effect of Estriol Cream combined with cervical dilatation stick during removal of intrauterine device in postmenopausal women
YAN Hua;WANG Hong;XU Wen-jin;PIAO Shu-hua
Objective
To evaluate the clinical effect of usering Estriol Cream combined with cervical dilatation stick by softening the cervix on removal of intrauterine device for postmenopausal women.
Methords
A total of 200 postmenopausal women required removal of intrauterine device from January 2015 to January 2017 were selected,randomly divided into control group and observation group,100 cases in each group.The observation group was givened Estriol Cream 0.5 mg/d in vaginal for 2 weeks before operation,and cervical dilatation stick were placed in the cervix for sofening cervix during operation.The control group was given oral Estradiol valerate 1 mg/d for 1 week before operation,Intrauterine device was removed by conventional method in both group.The difficulty of operation and the degree of pain in both groups were compared statistically.
Results
There were no statistically significant difference in smooth,difficulty and failure rate of removal of intrauterine device between the observation group and the control group(P＞0.05）.Compared with the control group,the rate of mild pain was higher,while the rate of moderate and severe pain was lower in the observation group,there was significant difference between the two groups(P<0.01）.
Conclusion
s The clinical application effect of Estriol Cream combined with cervical dilation stick in removal of intrauterine device in postmenopausal women is satisfactory and effective.It can alleviate the pain of patients and is worth promoting.
2018 Vol. 25 (26): 85-87 [
Abstract
] (
151
)
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21
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88
Clinical effect of Carboprost Suppository in prevention and treatment of postpartum hemorrhage and postoperative recovery in cesarean section
LIN Xiao-qi
Objective
To investigate the efficacy of Carboprost Methylester Suppository in the prevention and treatment of postpartum hemorrhage and postoperative recovery of caesarean section.
Methods
A total of 180 cases of cesarean section mothers who were treated in our hospital from January 2016 to January 2017 were randomly divided into control group and experimental group,90 cases in each group.The patients in the control group were treated with oxytocin,and the patients in the experimental group were treated with oxytocin and combined with Cardoprostol Suppository.The effect of maternal satisfaction and maternal satisfaction were compared between the two groups.
Results
The 24-hour blood loss was lesser than that in the control group and postoperative anus exhaustion time was shorter in the experimental group than that in the control group.The recovery rate was 97.78%in the experimental group after 3 days,which was significantly higher than that in the control group (80.00%).There were statistically significant differences between the two groups(P＜0.05）.The satisfaction rate of the cesarean section in the experimental group was 98.89%,which was significantly higher than that of the control group (86.67%),the difference was statistically significant(P＜0.05）.
Conclusion
On the basis of oxytocin,cesarean section mothers combined with Carboprost Methylester Suppository treatment can effectively prevent and treat postpartum hemorrhage in cesarean section mothers,and it is beneficial to postoperative recovery and worthy of clinical promotion.
2018 Vol. 25 (26): 88-90 [
Abstract
] (
159
)
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32
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91
Clinical effect of Kangfuyan Capsules enema combined with physiotherapy in treatment for female pelvic inflammatory diseases
YANG Jing
Objective
To investigate clinical effect of Kangfuyan Capsules enema combined with physiotherapy in treatment for female pelvic inflammatory diseases.
Methods
A total of 202 patients with female pelvic inflammatory disease were selected in hospital from November 2014 to November 2017,who were divided into two groups by random number table method,101 cases in each group.The control group was received traditional antibiotic therapy,the observation group was treated Kangfuyan Capsules enema combined with physiotherapy.Biochemical markers and pain score were performed before and after treatment.Clinical effect and adverse reactions were compared between two groups.
Results
Tumor necrosis factor α（TNF-α）,C reactive protein（CRP）,interleukin-6（IL-6）,VAS score decreased,while inflammatory mass diameter reduced,while pelvic effusion decreased after treatment in two groups(P＜0.05）.TNF-α,CRP,IL-6,VAS score in observation group were lower than that in the control group,while inflammatory mass diameter in observation group was smaller than that in the control group,while pelvic effusion in observation group was less than that in the control group,while total effective rate in observation group was higher than control group(P＜0.05）.There were no statistically significant differences on incidence of adverse reactions between two groups(P＞0.05）.
Conclusion
Kangfuyan Capsules enema combined with physiotherapy have significant effect in treatment for female pelvic inflammatory diseases,which are worthy of clinical application.
2018 Vol. 25 (26): 91-93 [
Abstract
] (
123
)
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23
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94
Effect comparison of mini-stimulation protocol and plan of ovulation induction at luteal phase in vitro fertilization embryo transfer cycle in patients with poor ovarian reserve
LIANG Jian-di;ZHANG Zhao
Objective
To investigate the value of mini-stimulation protocol and plan of ovulation induction at luteal phase in vitro fertilization embryo transfer cycle in patients with poor ovarian reserve.
Methods
From January 2015 to December 2017,98 patients with poor ovarian reserve were selected and divided into experimental group(n=52)and control group (n=46)according to the randomized control method.In the control group,min-stimulation protocol was used in vitro fertilized embryo transfer cycle,while in the experimental group,the ovulation induction plan at luteal phase in vitro fertilized embryo transfer cycle.The differences in clinical pregnancy rate and early miscarriage rate between the two groups were compared.
Results
In the experimental group,the use time and dosage of Gn,and E
2
level,number of ova retrieved,and number of embryos available at the injection day of human chorionic gonadotropin (HCG)were all higher than those in the control group.The level of luteinizing hormone(LH)at the HCG injection day was lower in the experimental group than that in the control group with statistical significance (P＜0.05）.In the experimental group,the clinical pregnancy rate was significantly higher than that in the control group(P＜0.05）.There was no early miscarriage rate or cycle cancellation rate (P＞0.05）.
Conclusion
The utility of ovulation induction plan at luteal phase in patients with poor ovarian reserve during in vitro fertilized embryo transfer cycle can increase the pregnancy rate of these patients and provide a new option for superovulation of patients with poor ovarian reserve.
2018 Vol. 25 (26): 94-96转99 [
Abstract
] (
128
)
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97
The clinical effect of orthodontic treatment on adult periodontitis
JIN Fu;LYU Hai-yan
Objective
To explore the clinical effect of orthodontic treatment for adult periodontitis.
Methods
Altogether 50 patients with periodontal disease admitted to our hospital from April 2014 to April 2017 were selected as objects and divided into the control group and the observation group according to the treatment plan,25 cases in each group.The control group received basic treatment,while the observation group received orthodontic treatment on the basis of the control group.The therapeutic effect,bleeding index,periodontal pocket depth,anterior teeth coverage and treatment time of two groups were compared.
Results
The total effective rate of the observation group was 96%,which was significantly higher than that of the control group (72%),and the difference was statistically significant(P<0.05).The bleeding index,periodontal pocket depth and anterior teeth coverage in the observation group were lower than those in the control group,the treatment time was shorter than that in the control group,and the differences were statistically significant(P<0.05).
Conclusion
For the patients with periodontitis,oral orthodontic treatment is effective,which can control periodontitis,restore the function of occlusion and the beauty,and improve the life quality of patients.It is worthy to be further discussed and popularized in the clinic.
2018 Vol. 25 (26): 97-99 [
Abstract
] (
123
)
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24
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100
Clinical study of Ephedrine Nasal Drops with different postures in the prevention of barotrauma of the middle ear caused by hyperbaric oxygenation
PENG Long-jiao;FENG Mei-lian;HE San-jiao;LUO Xiao-xiao
Objective
To investigate the clinical effect of Ephedrine Nasal Drops with different postures in the prevention of barotrauma of the middle ear caused by hyperbaric oxygenation.
Methods
A total of 60 patients who underwent the hyperbaric oxygen therapy for the first time in our hospital from January 2014 to November 2017 were selected as objects.They were randomly divided into observation group (n=30)and control group (n=30).The two groups of patients were treated in the same capsule,and the Ephedrine Nasal Drops were used before entering the capsule on the 1
st
,2
nd
and 3
rd
days.Patients in the control group received Ephedrine on the supine position,while head-side in 45°on the horizontal position was adopted in the observation group.The occurrence of barotrauma of the middle ear,the extent of tympanic membrane damage,and hyperbaric oxygen therapy tolerance were compared in order to analyze and evaluate the effect of different positions of Ephedrine Nasal Drops on the prevention of barotrauma of the middle ear caused by hyperbaric oxygen therapy and the influence on patient′s tolerance.
Results
The incidence of the middle ear barotrauma in the observation group was 6.66%,which was significantly lower than that in the control group accounting for 26.66%,and the difference was statistically significant(P<0.05).The degree of tympanic membrane damage was significantly lighter than that in the control group,and the difference was statistically significant(P<0.05).The tolerance of hyperbaric oxygen treatment in the observation group was 93.33%,which was significantly higher than that in the control group accounting for 73.33%,and the difference was statistically significant(P<0.05).
Conclusion
Ephedrine Nasal Drops in patients with head-side in 45°on the horizontal position is helpful to reduce the incidence of barotrauma of the middle ear,alleviate the degree of tympanic membrane damage,and increase the patients′tolerance to hyperbaric oxygen therapy,which obtains a remarkable effect and is worthy of clinical reference and promotion.
2018 Vol. 25 (26): 100-102 [
Abstract
] (
113
)
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103
Effect of Cetylpyridnium Chloride Gargle in the treatment of gingivitis
GONG Da-dong
Objective
To investigate the effect of Cetylpyridnium Chloride Gargle in the treatment of gingivitis.
Methods
A total of 74 cases of patients with gingivitis treated in our hospital from March 2017 to April 2018 were selected as the subjects.According to the different treatment methods,they were divided into the observation group (n=37)and the control group (n=37).The control group was treated with the Compound Chlorhexidine Gargle,and the observation group was treated with the Cetyly ridniwm Chioride Gargle.The plaque index(PLI),gingival index(GI),and total effective rate of treatment were compared between two groups.
Results
There was no significant difference in PLI index before treatment between two groups (P>0.05).The PLI on the 1
st
,4
th
,and 7
th
days after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The PLI of the observation group on the 1
st
,4
th
and 7
th
days after treatment were lower than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in GI before treatment between two groups(P>0.05).The GI on the 1
st
,4
th
,and 7
th
days after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The GI of the observation group on the 1
st
,4
th
and 7
th
day after treatment were lower than those of the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).
Conclusion
The application of Cetylpyridnium Chloride Gargle in the treatment of gingivitis can play an important role in the inhibition of plaque formation and the improvement of gingivitis.Therefore,its clinical value is significant.
2018 Vol. 25 (26): 103-105 [
Abstract
] (
119
)
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21
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106
Effect comparison of one-time root canal therapy and multiple root canal therapy in the treatment of dental pulp disease
ZENG Juan
Objective
To compare the effect of one-time root canal therapy and multiple root canal therapy in the treatment of dental pulp disease.
Methods
A total of 98 cases of patients with dental pulp disease treated in our hospital from October 2016 to February 2018 were selected as the subjects.According to the random number table method,they were divided into the control group and the observation group,49 cases in each group.The control group was treated with multiple root canal therapy,and the observation group was treated with one-time root canal therapy.The clinical effect,operation time and complication were compared between two groups.
Results
The total effective rate of treatment in the observation group (93.88%)was significantly higher than that in the control group (77.55%),and the difference was statistically significant(P<0.01).The operation time of the observation group was significantly shorter than that of the control group,and the difference was statistically significant(P<0.01).The incidence of complications in the observation group(6.12%)was significantly lower than that in the control group(20.41%),and the difference was statistically significant(P<0.01).
Conclusion
Compared with the multiple root canal therapy,the clinical effect of onetime root canal therapy in the treatment of dental pulp disease is more significant,which can not only shorten the time of treatment,but also have high safety.It is worthy of clinical application.
2018 Vol. 25 (26): 106-108 [
Abstract
] (
107
)
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28
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109
Clinical effect of open tympanoplasty combined with radical mastoidectomy in the treatment of chronic suppurative otitis media
CHEN Wei-feng
Objective
To explore the clinical effect of open tympanoplasty combined with mastoidectomy in the treatment of chronic suppurative otitis media.
Methods
A total of 116 patients with chronic suppurative otitis media who were admitted to our hospital from August 2016 to August 2017 were selected as the study subjects.According to the random number table method,they were divided into simple group and combined group,with 58 cases in each group.The simple group was given radical mastoidectomy alone,and the combined group was given open tympanoplasty combined with radical mastoidectomy.The total effective rate of treatment,the shape change of the external auditory canal after surgery,and ear dryness time were compared between two groups.
Results
The total effective rate in the combined group was 98.28%,which was significantly higher than that in the simple group (86.21%),and the difference was statistically significant(P<0.05).Improvement of external auditory canal shape after surgery in the combined group(the normal rate[93.10%],the small cavity rate[3.45%],the mid-cavity rate[3.45%],the large cavity rate[0.00%])were superior to those in the simple group (the normal rate [10.34%],the small cavity rate [34.48%],the mid-cavity rate[44.83%],the large cavity rate [10.34%]),and the differences were statistically significant(P<0.05).The average ear dryness time after treatment in the combined group was(33.56±2.47)d,which was significantly shorter than that in the simple group of(45.67±3.45)d,and the difference was statistically significant(P<0.05).
Conclusion
For patients with chronic suppurative otitis media,the effect of open tympanoplasty combined with mastoidectomy is significant.It can shorten the postoperative ear dryness time and improve the life quality of patients,which is worthy of further clinical application.
2018 Vol. 25 (26): 109-111 [
Abstract
] (
100
)
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29
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112
Influence of Dexmedetomidine on renal function in patients with severe burn
HUANG Yi-sheng;ZHONG Bao-lin;JIANG Cui-hua
Objective
To explore the influence of Dexmedetomidine on renal function in patients with severe burn.
Methods
Seventy-two patients with severe burn treated in our hospital from January 2017 to January 2018 were selected as subjects,and they were divided into the two groups according to the random number table method,each group had 36 cases.Patients in the study group were given Dexmedetomidine for intravenous pump during escharectomy and dermatoplasty,while patients in the control group were given normal saline of equal volume for or intravenous pump during escharectomy and dermatoplasty.The concentration of serum creatinine,urea nitrogen and serum cystatin C were compared between the two groups at different time points.
Results
There was no significant difference in serum creatinine concentration between the two groups at 10 min before anesthesia induction (t
1
)(P>0.05).The serum creatinine concentration in the study group was significantly lower than that in the control group at 30 min after escharectomy and dermatoplasty(t
2
),10 min before the end of the operation(t
3
),24 h after operation(t
4
)and 72 h after operation(t
5
),and the differences were statistical significant(P<0.05).There was no significant difference in the concentration of urea nitrogen between the two groups at t
1
(P>0.05).At t
2
,t
3
,t
4
and t
5
,the concentration of urea nitrogen in the study group was significantly lower than that in the control group,and the differences were statistical significant(P<0.05).There was no significant difference in serum cystatin C concentration between the two groups at t
1
(P>0.05).At t
2
,t
3
,t
4
and t
5
,the concentration of serum cystatin C in the study group was significantly lower than that in the control group,and the differences were statistical significant(P<0.05).
Conclusion
The application of Dexmedetomidine during operation can protect the renal function of patients with severe burn,and it is metabolized through the liver.The clearance rate does not depend on the renal function,so Dexmedetomidine is an extremely ideal anesthetic drug for patients with severe burn.
2018 Vol. 25 (26): 112-114 [
Abstract
] (
112
)
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26
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115
Application effect comparison of body surface marker localization and ultrasound guided localization in anesthesia for cesarean section parturients
LIU Kai-min;CHEN Chun
Objective
To compare the application effect of body surface marker localization and ultrasound guided localization in anesthesia for cesarean section parturients.
Methods
A total of 92 parturients with cesarean section treated in our hospital from August 2016 to August 2017 were selected as the subjects,and they were divided into the study group and control group according to their hospitalization order,there were 46 cases in each group.The control group was given body surface marker localization,while the study group was given ultrasound-guided localization,the anesthesia indexes and the incidence of complications of the two groups were observed.
Results
The positioning time before anesthesia in the study group was significantly longer than that in the control group,the success rate of the first puncture in the study group was significantly higher than that in the control group,and the differences were statistical significant(P<0.05).There was no statistical difference in the rate of converting to epidural anesthesia between the two groups(P>0.05).The incidence of various complications in the study group was significantly lower than that in the control group respectively(P<0.05).
Conclusion
Compared with body surface marker localization,ultrasound-guided localization is better in anesthesia for cesarean section parturients,although its positioning time before anesthesia is longer than that of body surface marker localization,but it can effectively promote the success rate of first puncture and effectively reduce the complications related to anesthesia.It is worthy of clinical promotion and application.
2018 Vol. 25 (26): 115-117 [
Abstract
] (
125
)
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31
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118
Comparison the clinical effect of Dezocine and Tramadol used in postoperative patient-controlled analgesia in department of orthopedics
HE Man;HAN Qiang;ZHANG Xian-wei
Objective
To compare the effect of Dezocine and Tramadol used in postoperative patient-controlled analgesia in department of orthopedics.
Methods
A total of 100 patients with lower extremity long bone fracture underwent general anesthesia in our hospital from January to May 2017 were selected,and they were divided into the group D(50 cases)and group Q (50 cases)according to the random number table method.Group D was treated with Dezocine plusing Sufentanil for analgesia,while the group Q was treated with Tramadol and Sufentanil after operation.Pain visual analogue scale (VAS),PCA compression times,PCA dosage of drugs at different time points,sedation score,incidence of adverse reactions and satisfaction degree were compared between the two groups.
Results
There were no significant differences in VAS score at different time points in the state of rest and movement after operation,PCA compression times and PCA dosage of drugs at different time points after operation,sedation score and satisfaction score between the two groups(P>0.05).The incidence of postoperative nausea and vomiting (PONV)in the group D was lower than that in group Q,and the difference was statistically significant(P<0.05).
Conclusion
Dezocine and Tramadol have similar PCA effect on after orthopaedic surgery,but the incidence of PONV is lower.
2018 Vol. 25 (26): 118-120转124 [
Abstract
] (
123
)
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26
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121
Influence of different dose of Dexmedetomidine combined with Ropivacaine on brachial plexus block effect
WANG Wei-ku;LI Ren-shu
Objective
To explore the influence of different dose of Dexmedetomidine combined with Ropivacaine on brachial plexus block effect.
Methods
A total of 105 patients with selective upper extremity surgery in our hospital from January to December 2017 were selected as the study subjects,and they were divided into the three groups,and there were 35 cases in each group according to the random number table method.Patients in the observation group 1 were treated with 100 μg Dexmedetomidine combined with 40 ml Ropivacaine (0.375%),patients in the observation group 2 were treated with 50 μg Dexmedetomidine combined with 40 ml Ropivacaine(0.375%),and the control group was treated with 40 ml Ropivacaine (0.375%).The time to block onset,duration of block,pain and analgesia,cortisol concentration,and safety of anesthesia were compared among the three groups.
Results
The onset time of sensory nerve and motor nerve block in the observation group 1 were shorter than those in the observation group 2 and the control group,and the duration of block in the observation group 1 were longer than those in the observation group 2 and the control group,and the differences were statistically significant(P<0.05).The first pain time and postoperative analgesia time in the observation group 1 were shorter than those in the observation group 2 and the control group,and the first pain score of the observation group 1 was lower than that in the observation group 2 and control group,and the difference was statistically significant(P<0.05).The cortisol concentration at nerve block 10min and at the beginning of the operation in the three groups were significantly higher than those before onset of anesthesia,and the cortisol concentration at nerve block 10 min and at the beginning of the operation in the observation group 1 were lower than those in the observation group 2,and the observation group 2 was lower than those of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions among the three groups (P>0.05).
Conclusion
Brachial plexus block with 100 mg Dexmedetomidine combined with 40 ml Ropivacaine(0.375%)applied in patients with upper extremity surgery can improve the effect of brachial plexus block,and is safe and effective.It has the advantage of clinical application.
2018 Vol. 25 (26): 121-124 [
Abstract
] (
111
)
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27
)
125
Effect study of different concentrations of Sevoflurane for general anesthesia induction on maternal and newborn during perioperative period of cesarean section
HUANG Wei-zhong LIN Jia-shan ZHONG Ni ZHOU Nan-xian PENG Kai
Objective
To explore the effect of different concentrations of Sevoflurane for general anesthesia induction on maternal and newborn during perioperative period of cesarean section.
Methods
A total of 100 parturients with cesarean section of general anesthesia treated in our hospital from February 2015 to August 2017 were selected,and they were divided into the 4 groups,and there were 25 cases in each group according to the random number table method.Group A was induced by 8%Sevoflurane for general anesthesia,group B was induced by 6%Sevoflurane for general anesthesia,group C was induced by 4%Sevoflurane for general anesthesia,and group D was induced by 2%Sevoflurane for general anesthesia.The SBP,DBP,HR before anesthesia induction(T
0
),immediately after induction(T
1
),after tracheal intubation(T
2
),and at the beginning of operation(T
3
)and bleeding volume,consciousness disappearance time,operation time,PaO
2
,PaCO
2
,pH value,Apgar score were compared in parturients among the four groups.
Results
In group A,the value of SBP,DBP and HR at T
1
,T
2
and T
3
were lower than at T
0
(P<0.05),in group B,the value of SBP,DBP and HR at T
1
and T
2
were lower than T
0
time(P<0.05),there was no significant difference in SBP,DBP and HR at T
1
,T
2
and T
3
in group C when compared with T
0
(P>0.05).In group D,the value of SBP,DBP and HR at T
2
and T
3
were higher than those in T
0
(P<0.05).The bleeding volume in group D were significantly more than those in group A,B and C,consciousness disappearance time and operation time in group D were significantly longer than those in group A,B and C (P<0.05).There was no statistical difference in PaO
2
,PaCO
2
and pH among the four groups(P>0.05),and the newborn Apgar score of 5 min in the 4 groups were higher than those of at 1 min (P<0.05).
Conclusion
Different concentrations of Sevoflurane inhalation can be safely used for induction of general anesthesia in cesarean section,but 4%Sevoflurane for general anesthesia induction has little effect on the parturients undergoing cesarean section,and will not affect the newborn.
2018 Vol. 25 (26): 125-127 [
Abstract
] (
120
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128
Effect comparison of Flurbiprofen Axetil and Parecoxib Sodium injection in preemptive analgesia and postoperative analgesia in orthopedic surgery
LI Min;DONG Mei-rong;YU Chang;LIN Li
Objective
To explore and analyze the effect of Flurbiprofen Axetil and Parecoxib Sodium injection on preemptive analgesia and postoperative analgesia in orthopedic surgery.
Methods
A total of 150 patients with orthopaedic surgery in our hospital from July 2016 to August 2017 were selected,and divided into the two groups according to the random number table,and there were 75 cases in each group.In control group,at 15 min before operation,the observation group was treated with Flurbiprofen Axetil and the control group was treated with Parecoxib Sodium.Pain score,serum inflammatory factors and adverse reactions were compared between the two groups.
Results
The pain scores at 6,12,24 h after operation in the two groups were significantly lower than those immediately after operation (P<0.05),the pain score of the observation group was lower than that of the control group at different time points after operation (P<0.05).The serum levels of inflammatory factors in the two groups 24 hours after operation were significantly higher than those before operation(P<0.05).There was no significant difference in serum TNF-α,IL-6 and CRP level between the two groups before operation (P>0.05).The level of serum TNF-α,IL-6 and CRP in the observation group were significantly lower than those in the control group 24 hours after operation (P<0.05).The total incidence of adverse reactions in the observation group was 6.67%,which was lower than that in the control group (20.00%)(P<0.05).
Conclusion
Preemptive analgesia with Flurbiprofen Axetil for orthopaedic surgery patients can effectively alleviate postoperative pain,alleviate inflammatory reaction in vivo and reduce the occurrence of adverse reactions,which is worthy of promotion and application.
2018 Vol. 25 (26): 128-130 [
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148
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131
Application effect of intravenous combined anesthesia in painless induced abortion
ZHENG Qiu-wu;LIU Li-li;KE Pin-hui
Objective
To explore the application effect of intravenous combined anesthesia in painless induced abortion.
Methods
A total of 124 patients with painless induced abortion in the First Hospital of Putian City,Fujian Province from November 6,2016 to February 14,2018 were selected as the research objects,they were divided into the observation group and control group according to the order of treatment,with 62 cases in each group.The control group was given intravenous Propofol,while the observation group was given Propofol,Fentanyl and Atropine intravenous anesthesia.The anesthesia induction time,awake time,bleeding time,heart rate,oxygen saturation,partial pressure of carbon dioxide and the incidence of complications were compared in patients between the two groups.
Results
The induction time of patients in the observation group([20.32±1.25]min)was longer than that in the control group,the awake time([15.32±1.32]min)and bleeding time([5.10±0.36]d)were shorter than those in the control group,and the differences were statistically significant(P<0.05).The heart rate([79.25±0.36]beats/min)and partial pressure of carbon dioxide([40.01±0.45]mmHg)of patients in observation group were lower than those in control group,the blood oxygen saturation([90.36±1.32]%)were higher than those of the control group,and the differences were statistically significant(P<0.05).The total incidence of complications in observation group was 1.61%,which was lower than that in control group(16.13%)(P<0.05).
Conclusion
Propofol,Fentanyl and Atropine combined intravenous anesthesia in painless induced abortion has high clinical value,can play a significant analgesic effect on the basis of reducing the incidence of complications,and it is worthy of application and promotion.
2018 Vol. 25 (26): 131-133 [
Abstract
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110
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134
Application effect of low dose Ropivacaine with different concentrations in elderly patients undergoing total knee arthroplasty
CHENG Miao
Objective
To analyse the application effect of low dose Ropivacaine with different concentration in elderly patients undergoing total knee arthroplasty.
Methods
A total of 100 elderly patients with knee and hip arthroplasty treated in our hospital from October 2013 to October 2016 were selected as the research subjects,and they were divided into the control group and observation group according to computer random grouping method,and there were 50 cases in each group.The control group was anesthetized with 0.50%Ropivacaine while the observation group was anesthetized with 0.25%Ropivacaine.The incidence of adverse reactions,total effective rate,mean blood pressure and heart rate between the two groups were compared.
Results
The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The mean blood pressure of the observation group was higher than that of the control group,heart rate of the observation group was higher than that of the control group,and the differences were statistically significant(P<0.05).
Conclusion
After 0.25%Ropivacaine anesthesia for elderly patients undergoing knee and hip replacement can achieve a significant anesthetic effect.
2018 Vol. 25 (26): 134-136 [
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127
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137
Application of general anesthesia combined with regional nerve block in patients with colorectal cancer undergoing laparoscopic surgery
GAO Jing-bin;GUO Ying;LI Dong-wei
Objective
To explore the application effect of general anesthesia combined with regional nerve block in patients with colorectal cancer undergoing laparoscopic surgery.
Methods
All of 90 patients with colorectal cancer scheduled for laparoscopic colorectal cancer surgery diagnosed and treated in department of general surgery of our hospital from February to October 2017 were systematically reviewed.Patients were divided into group A,B,C according to the different anesthesia methods,and there were 30 cases in each group.Group A received simple general anesthesia,group B received general anesthesia combined with epidural block,group C received general anesthesia combined with regional nerve block.The postoperative exhaust time,bed rest time,hospitalization stay,and heart rate (HR)and mean arterial pressure (MAP)at the beginning of anesthesia,during skin incision and skin closure in patients of the three groups were recorded,the postoperative pain score of 6,12,24 h were recorded and compared in all patients.
Results
The exhaust time,bed rest time and hospitalization stay of group C were significantly shorter than those of group A and group B,and the differences were statistical significant(P<0.05).HR and MAP in patients of group C during skin incision and skin closure were significantly lower than those in group A and group B,and the differences were statistical significant(P<0.05).
Conclusion
General anesthesia combined with regional nerve block applied in patients with colorectal cancer undergoing laparoscopic surgery can effectively shorten the postoperative recovery time,reduce stress response,relieve surgical pain,the effect is definite.
2018 Vol. 25 (26): 137-139转143 [
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120
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140
Clinical value of general anesthesia with laryngeal mask airway preserving spontaneous breathing for thoracoscopic bullae resection
WANG Wei;ZHANG Cheng-zuo;LI Xue
Objective
To explore the clinical value of general anesthesia with laryngeal mask airway preserving spontaneous breathing for thoracoscopic bullae resection.
Methods
A total of 62 patients with thoracoscopic bullae resection in our hospital from October 2016 to October 2017 were selected,all patients were treated with the same induction and maintenance of total intravenous anesthesia.The patients were divided into the two groups using the random number table method.31 patients in the control group were treated with muscle relaxant and inserted into double lumen bronchial catheter,31 patients in the observation group were inserted into laryngeal mask having no muscle relaxant to retain spontaneous respiration.The monitoring indexes(heart rate,mean arterial pressure,arterial oxygen saturation,arterial carbon dioxide saturation)were recorded at different time points(at laryngeal mask implanted,the laryngeal mask implanted for 30 min and 60 min)were recorded in patients of the two groups.The recovery(recovery time,postoperative hospital stay),hospitalization expenses,adverse reactions(shock,hoarseness,pharyngeal discomfort,dysphagia,upper respiratory tract obstruction)were compared between the two groups.
Results
The arterial oxygen saturation of the observation group was higher than that of the control group when the laryngeal mask was implanted for 30 min and 60 min respectively,carbon dioxide saturation of arterial blood in the observation group was lower than that in the control group when the laryngeal mask was implanted for 30 min and 60 min respectively (P<0.05).The recovery time and postoperative hospitalization time of the observation group were shorter than those of the control group (P<0.05),and the hospitalization expenses of the observation group were less than those of the control group(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05).
Conclusion
General anesthesia with laryngeal mask retaining spontaneous respiration is suitable for thoracoscopic pulmonary bullae resection.It can improve the oxygen saturation of patients and improve the safety of operation.
2018 Vol. 25 (26): 140-143 [
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123
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144
Effect of Dust Mite Drops combined with Desloratadine Citrate Disodium in the treatment of chronic urticaria induced by dust mite allergy
YANG Rong-qing;YANG Chi-mei;HUANG Jie
Objective
To observe the effect of Dust Mite Drops combined with Desloratadine Citrate Disodium in the treatment of chronic urticaria induced by dust mite allergy.
Methods
Altogether120 patients with chronic urticaria who were treated in the outpatient of our hospital from January 2015 to June 2016 were selected as objects.They were divided into the experimental group (60 cases)and the control group (60 cases)according to the random number table method.The experimental group was sublingually administered with Dust Mite Drops for 1 year,and they were orally given Desloratadine Citrate Disodium Tablets of 8.8 mg at the same time,once a day,for 4 weeks.After 4 weeks,the doses were reduced or stopped according to the control of urticaria symptoms.The control group was only orally given 8.8 mg of Desloratadine Citrate Disodium Tablets,whose method and course of treatment were the same as the experimental group.Follow-up visits were conducted 4 weeks,3,6,9 months,and 1 year after treatment.The total effective rate,overall satisfaction,and incidence of adverse reactions were compared between two groups.
Results
The total effective rate in the experimental group after 3,6,9 months and 1 year of treatment was higher than that after 4 weeks of treatment,and the differences were statistically significant(P<0.05).The total effective rate of the control group after 3 months and 6 months of treatment was not significantly different from that after 4 weeks of treatment(P>0.05).The total effective rate after 9 months and 1 year of treatment in the control group were higher than those after 4 weeks of treatment,and the differences were statistically significant(P<0.05).There was no significant difference in the total effective rate between two groups after 4 weeks of treatment(P>0.05).The total effective rate after 3,6,9 months and 1 year of treatment in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05).At the end of the one-year observation period,the overall satisfaction in the experimental group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).The adverse reactions in both groups were relatively mild and did not affect continuing treatment.
Conclusion
Sublingual administration of Dust Mite Drops combined with Desloratadine Citrate Disodium in the treatment of dust mite-positive chronic urticaria is effective,convenient and safe.
2018 Vol. 25 (26): 144-146转151 [
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119
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147
Analysis on common irrational drug use in 548 medical orders from pharmacy intravenous admixture services
LU Min;ZHANG Gui-fen;XIE Dan;ZOU Yin;CHEN Rui-huan
Objective
To investigate the intervention on irrational medical orders in pharmacy intravenous admixture service(PIVAS)of Changshu NO.1 People′s Hospital(hereinafter referred to as"our hospital"),so as to provide reference for the rational drug use in clinic.
Methods
The irrational medical orders intervened by the prescription pharmacists of PIVAS were collected in our hospital from January 2016 to December 2017 and irrational drug use was retrospectively analyzed.
Results
From January 2016 to December 2017,the 1 137 700 and 999 100 medical orders in PIVAS each were configured.The irrational medical orders were 301(0.0265%)and 247(0.0247%).In the department of general surgery,the oncology department and the emergency internal medicine,the number of irrational medical orders was more.The main types of irrational drug use were improper selection of solvent types(38.89%),improper use of solvent(41.41%)and overdose use (7.91%).Irrational medical orders in the digestive system were the most,followed by vitamin nutrients (12.77%).
Conclusion
Pharmacists′examination of medical orders in PIVAS can reduce and avoid the occurrence of irrational drug use,improve the effectiveness and safety of medical treatement.This can fully reflect the value of the pharmacists.
2018 Vol. 25 (26): 147-151 [
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127
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152
Effect comparison of Triamcinolone Acetonide Econazole Cream and Miconazole Nitrate Cream in the treatment of fungal external otitis
CAI Qin-fang;OUYANG Shao-ji;LI Hui-juan
Objective
To compare the effect of Triamcinolone Acetonide Econazole Cream and Miconazole Nitrate Cream in the treatment of fungal external otitis.
Methods
A total of 200 cases of patients with fungal external otitis admitted to our hospital from May 2016 to May 2017 were selected as the study subjects,and they were randomly divided into experimental group(100 cases)and control group(100 cases).The control group was treated with external auditory canal flushing combined with Miconazole Nitrate Cream,while the experimental group was treated with external auditory canal flushing combined with Triamcinolone Acetonide Econazole Cream.The total effective rate and recurrence rate of two groups were compared.
Results
The total effective rate of the experimental group was higher than that of the control group,the recurrence rate was lower than that of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).
Conclusion
The curative effect of Triamcinolone Acetonide Econazole Cream is better than that of Miconazole Nitrate Cream,which is worthy of clinical application.
2018 Vol. 25 (26): 152-154 [
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180
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155
Clinical effect of Oxygen-driven Salbutamol Sulfate Inhalation Solution and Ipratropium Bromide Solution in the treatment of children with asthma
YANG Yi-xian
Objective
To study the clinical effect of Oxygen-driven Salbutamol Sulfate Inhalation Solution and Ipratropium Bromide Solution in the treatment of children with asthma.
Methods
A total of 140 children with asthma admitted to our hospital from January 2017 to December 2017 were selected randomly as objects.They were divided into the control group and the observation group according to the random synthetic sequential method,70 cases in each group.The control group was given conventional treatment,and the observation group was treated with Oxygen-driven Salbutamol Inhalation Solution and Ipratropium Bromide Solution.The rate of total effective and adverse reactions,lung function index,the scores of sleep quality and life quality were compared between two groups.
Results
The total effective rate in the observation group(98.57%)was higher than that in the control group(80.00%),and the difference was statistically significant(P<0.05).The rate of adverse reactions in the observation group(1.43%)was lower than that in the control group (17.14%),and the difference was statistically significant(P<0.05).The forced expiratory volume in one second,forced vital capacity and peak expiratory flow rate in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The score of sleep quality in the observation group was lower than that in the control group,the score of life quality was higher than that in the control group,and the differences were statistically significant(P<0.05).
Conclusion
Oxygen-driven Salbutamol Inhalation Solution and Ipratropium Bromide Solution have significant clinical effect in the treatment of children with asthma,which can improve the lung function indexes of children and reduce the occurrence of adverse reactions.The safety and reliability are high,which is worthy of clinical promotion.
2018 Vol. 25 (26): 155-157 [
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135
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158
Value of Alanine Aminotransferas in blood screening
LI Jie-min;CHEN Zhi-zhong;CHEN Shang-liang;LIAO Yang-xun;YU Wen-chao;LU Shao-fen;LIANG Jianfeng;LI Xun-wei
Objective
To study the relationship between alanine aminotransferase (ALT)and hepatitis A virus(HAV)and hepatitis G virus(HGV)and to evaluate its value in blood screening.
Methods
Blood samples from unpaid blood donors in Zhaoqing area from January to December 2017 were randomly collected,and five bloods transfusion tests(hepatitis B virus surface antigen[HBsAg],hepatitis C virus antibody[Anti-HCV],human immunodeficiency virus antibody[Anti-HIV],syphilitic spirulina[TP],human T lymphocytic leukemia virus[Anti-HTLV])were negative.Altogether 874 specimens with normal ALT(ALT≤50 U/L)were used as control group(393 specimens were used as the control group 1,and 481 specimens were used as the control group 2),and 135 specimens with abnormal ALT (ALT>50 U/L)were used as study group.Five blood transfusion infections were detected by nucleic acid detection technology(NAT)and enzyme-linked immunosorbent assay (ELISA).ALT was detected by rate method,and HAV-IgG and HGV-IgG were detected by ELISA.The blood samples from unpaid blood donors in Zhaoqing City from 2003 to 2017 were retrospectively analyzed.The abnormal rate of ALT in HbsAg positive blood donors (2216 cases)and Anti-HCV positive blood donors(664 cases)was investigated.
Results
HAV-IgG was detected both in the control group 1 and in the study group,352 cases(89.6%)were positive in the control group,and 110 cases(81.5%)were positive in the study group.The positive rate of HAV-IgG in the study group was lower than that in the control group 1,and the difference was statistically significant(P<0.05).The positive rate of HGV-IgG in the control group 2 and in the study group was 0.0%.There were 109 cases(4.9%)of ALT abnormalities in 2216 HBsAg-positive cases and 161 cases(24.2%)of ALT ab-normalities in 664 Anti-HCV-positive cases.The abnormal rate of ALT in HBsAg-positive cases was lower than that in Anti-HCV-positive cases,and the difference was statistically significant(P<0.05).
Conclusion
ALT is related to HCV,but after the specific test of ELISA and NAT,ALT test is no longer helpful to improve the residual risk of HCV.The positive rate of HAV-IgG in the study group is lower than that in the control group,but HAV is a non-bloodborne disease and did not help to improve the residual risk of blood safety.
2018 Vol. 25 (26): 158-160转178 [
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108
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161
Establishment of re-examination rules for automatic urine analyzer
LI Qing;WANG Fei;HAN Shu-xia
Objective
To establish a re-examination rule for the automatic urine analysis workstation consisting of Derry H-800 urine dry chemical analyzer and IRIS IQ-200 urine forming analyzer,and to verify the application of this rule in the clinic.
Methods
A total of 1715 specimens were tested by using this workstation.At the same time,each specimen was examined by urine sediments microscopic examination.Through the analysis of the test results of two methods,re-examination rules of the laboratory′s urine analysis workstation were developed and validated with 300 specimens.
Results
The results of the microscopic examination were taken as standards based on the examination of 1715 specimens.The false negative rate of the test results of urine analysis workstation was 1.22%,the false positive rate was 2.97%,and the re-examination rate was 33.41%.The results of the clinical specimen validation by the application of the re-examination rules were as follows:the false negative rate was 1.33%,the false positive rate was 1.66%and the re-examination rate was 35.33%.
Conclusion
The laboratory has developed and validated the re-examination rules for automated urine analysis workstation.The false negative rate,false positive rate and re-examination rate all can meet the requirements.This re-examination rule can be applied in clinical practice.
2018 Vol. 25 (26): 161-163 [
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128
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164
Analysis of poor vision in primary and middle school students in Zhujiajiao Town of Qingpu District，Shanghai
MA Ying
Objective
To understand the occurrence of poor vision in primary and middle school students from 2015 to 2017,and to analyze the characteristics of students′poor vision,so as to provide the basis for formulating the strategy of prevention and control of poor vision for primary and middle school students.
Methods
Data of 13 462 primary and middle school students′visual acuity from 2015 to 2017 in Zhujiajiao Towm of Qingpu District,Shanghai was collected,and the distribution of students′poor vision and their severity was analyzed,classified by age,grade and gender.
Results
The rate of poor vision of primary and middle school students from 2015 to 2017 was 38%,of which,the proportion of severe visual impairment was 47.63%,and the rate of poor vision and severe visual impairment increased with the increase of age.The rate of poor vision and severe visual impairment of girls were both higher than that of boys.
Conclusion
Comprehensive prevention and control measures should be implemented according to the characteristics of poor vision.
2018 Vol. 25 (26): 164-166 [
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121
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167
Analysis of hemoptysis after PCI in one patient with bronchiectasis
LU Chun-ling
Massive hemoptysis is a serious complication of bronchiectasis.When patients suffering from other complications,the risk of hemorrhage and thrombosis being coexistent,it is more difficult to treat in clinic.This article presents a case of massive hemoptysis after percutaneous coronary intervention (PCI)in a patient with bronchiectasis.The process of the clinical pharmacist participating in therapeutic regimen was introduced and the treatment scheme of hemostasis and antithrombosis was analyzed in order to explore how to selecte appropriate hemostatic drugs and determine the suitable antithrombotic treatment strategy in these special patients.The results showed that procaine can obtain good hemostasis in patients with severe hemoptysis after PCI,and reduce the incidence of adverse reactions;at the same time,it shortens the dual antiplatelet treatment course.The use of aspirin as a monoclonal antibody treatment can prevent the occurrence of bleeding and thrombotic events.
2018 Vol. 25 (26): 167-169 [
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130
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170
Retrospective analysis of a case of neuropsychiatric systemic lupus erythematosus encephalopathy complicated with posterior reversible encephalopathy syndrome
SONG Mei;WU Yan-ling;YU Min
Lupus erythematosus encephalopathy is a neurological and mental expression associated with nervous system damage in neuropsychiatric systemic lupus erythematosus(NPSLE).It can occur at any time in systemic lupus erythematosus and may even appear as the first symptom of SLE.The clinical symptoms vary,including headache,coma,convulsion,cranial nerve paralysis and mental symptoms.It can also be manifested as the form of posterior reversible encephalopathy syndrome (PRES).This article analyzes the cases of patients with the first symptom of NPSLE complicated with PRES,and discuss clinical diagnosis and treatment.
2018 Vol. 25 (26): 170-172 [
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114
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173
Rehabilitation training of functional limitation after multiple recurrent resection of right lower limb desmoid fibroma：a case report
LIAN Hong-qiang;ZHANG Li-rong;XU Tao;SHI Bin;ZHOU Xiao-bin;JI-Jing
Desmoid fibroma is a non-distant metastatic soft tissue tumor without reason local invasion and easy recurrence,that occurs in 30-50 women than in adolescents.WHO classified ligamentoid fibroma as fibroblast tumor in the 2002.According to biological features belong the intermediate type.The clinical manifestation is local hard and painless mass,which is destructive to local tissue.This disease treatments included chemotherapy,radiotherapy and surgical treatment,multiple operations will affect the patientundefineds ADL function.A case of ligamentoid tumor of right lower extremity was treated with comprehensive treatment.Through systematic rehabilitation,finally obviously improved the patientsundefined ADL function.We summarize the experiences of rehabilitation therapy,so as to provide more patients with similar treatment with this article.
2018 Vol. 25 (26): 173-175 [
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119
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176
Application effect of emergency grading and sub-distribution mode in triage of patients with acute pancreatitis
LI Min
Objective
To explore the application effect of emergency grading and sub-diagnosis mode in the triage of patients with acute pancreatitis(AP).
Methods
A total of 84 patients with AP admitted to our hospital from January 2016 to January 2018 were selected and they divided into study group (43 cases)and reference group (41 cases)according to the order of treatment.The study group was implemented the emergency grading and zoning triage mode,and the reference group was implemented the regular mode.The waiting time,treatment waiting time,triage accuracy,treatment success rate,nursing satisfaction and nursing disputes were compared between the two groups.
Results
The waiting time and treatment waiting time of the study group were shorter than that in the reference group,and the accuracy of diagnosis and success rate of treatment were significantly higher than that of the reference group(P<0.05）.The nursing satisfaction of the study group was 95.35%,which was significantly higher than that of the reference group(73.17%,P<0.05）.The incidence of nursing disputes in the study group was 2.33%,which was significantly lower than that of the 14.63%in the reference group,the differences were statistically significant(P<0.05）.
Conclusion
The implementation of emergency grading and zoning triage mode in patients with AP can effectively shorten the waiting time and treatment waiting time,improve the accuracy of triage diagnosis,success rate of treatment and satisfaction of nursing,and reduce the occurrence of medical disputes,worthy of clinical application.
2018 Vol. 25 (26): 176-178 [
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133
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Application of psychological nursing interventions in the rehabilitation of orphaned and disabled children
XIE Dong-Zhi;SU Hong-Mei
Objective
To analyze the clinical application of psychological nursing interventions in the rehabilitation of orphaned and disabled children.
Methods
A total of 126 orphaned and disabled children treated from October 2015 to October 2017 in our hospital were selected.The subjects were divided into two groups according to the registration number,63 cases each group.The conventional nursing care was applied in the control group;the psychological nursing interventions were applied in the observation group.The SAS(self-rating anxiety scale)points,SDS(self-rating depression scale)points and ADL (activity of daily living)scores were assessed.
Results
Before intervention,the SAS points and SDS points for two groups were not significantly different(P＞0.05）.After intervention,the SAS points and SDS points for observation group were significantly lower than those in the control group (P<0.05）.Before intervention,the ADL scores for two groups were not significantly different(P＞0.05）.After intervention,the ADL scores for observation group were significantly higher than that in the control group (P<0.05）.
Conclusion
The psychological nursing interventions can relieve their anxiety and depression and improve the life quality.
2018 Vol. 25 (26): 179-181 [
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122
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Intervention of swallowing function training on dysphagia in tumor patients after radiotherapy
GONG Qiu-yan
Objective
To investigate the effect of swallowing training on dysphagia in tumor patients with radiotherapy.
Methods
Seventy-six patients with dysphagia after radiotherapy from September to November 2017 in our hospital were selected as study subjects.They were divided into control group and observation group by a random number table.Patients in control group were provided with routine nursing,while in observation group,swallowing function training was performed on the basis of the control group.The functional oral intake scale (FOIS)score,drinking water test,and quality of life were observed before and after the intervention in the two groups.
Results
Before the intervention,there was no significant difference in FOIS scores between the two groups(P＞0.05）.After 1 and 3 months intervention,FOIS score in the observation group were higher than those in the control group (P<0.05）.Before intervention,there was no significant difference in the drinking water test results(P＞0.05）.The drinking water test result in the observation group after intervention was superior to that in the control group (P<0.05）.There was no significant difference in the MD Anderson Dysphagia Inventory(MDADI)score between the two groups before intervention(P＞0.05）.The MDADI score in the observation group was higher than that in the control group,the differences were statistically significant(P<0.05）.
Conclusion
Swallowing function training can effectively relieve dysphagia in tumor patients after radiotherapy.It can also promote oral intake and improve patient’s quality of life,which is worthy of clinical promotion.
2018 Vol. 25 (26): 182-184转188 [
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120
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Individualized nursing intervention reduces urinary retention after cervical cancer surgery
QIU Wei-hong;ZHANG Shao-qun;HUANG Juan
Objective
To explore the influence and practice of individualized nursing intervention on the incidence of urinary retention after radical treatment of cervical cancer （CC）.
Methods
A total of 92 patients with CC radical surgery were selected from march 2015 to July 2016 in the department of gynecology of our hospital,they were randomly divided into observation group and control group,46 cases in each group.Patients in the control group were routinely treated with extensive total hysterectomy and pelvic lymph node dissection.On the basis of routine care of the observation group was given personalized nursing intervention.The incidence of postoperative urinary retention,recatheter rate,average length of stay and nursing satisfaction were compared between the two groups.
Results
In the observation group,the incidence of urinary retention and the resetting rate were significantly lower than that in the control group(P＜0.05）.The time of indwelling catheter in the observation group was shorter than that in the control group,the difference was statistically significant(P＜0.05）.The average length of hospital stay in the observation group was shorter than that in the control group,the difference was significant(P＜0.05）.The satisfaction of the patients in the observation group was significantly higher than in the contol group,the difference was significant(P＜0.05）.
Conclusion
Personalized nursing intervention in patients with CC radical prostatectomy,which can effectively reduce the incidence of urinary retention,to speed up the restore bladder function,can shortenthe patient′s average hospitalization days,effectively reduce the medical expenses,and iprove patients satisfaction of nursing work.
2018 Vol. 25 (26): 185-188 [
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100
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Influence of comprehensive care on patients with chronic sinusitis treated by endoscopic surgery
ZHOU Xiao-ling;XU Wen-ting
Objective
To investigate the nursing intervention of patients with chronic sinusitis treated by endoscopic surgery.
Methods
A total of 90 patients with chronic sinusitis who underwent nasal endoscopic surgery in our hospital from June 2016 to November 2017 were divided into two groups according to random numberl table method,45 cases in each group.In the control group,routine nursing intervention was used,while comprehensive care was adopted in the rest participants (comprehensive care group).Satisfaction with nursing services,perioperative pain,surgical treatment compliance,self-rating anxiety scale(SAS)score and heart rate(HR)before and after nursing,and incidence of complications such as conjunctival chemosis and local hemorrhage during endoscopic surgery for chronic sinusitis in the two groups were compared.
Results
In the comprehensive care group,satisfaction with nursing services was higher than that in the control group (P＜0.05）.The perioperative pain in the comprehensive care group was lower,and the surgical treatment compliance was higher than those in the control group with statistical significance (P＜0.05）.Before nursing,there was no great difference in SAS score or HR between the two groups (P＞0.05）.After nursing,the SAS score and HR in the comprehensive care group were both lower than those in the control group with statistical significance(P＜0.05）.The incidence of complications such as conjunctival chemosis and local hemorrhage in the comprehensive care group were lower than that in the control group (P＜0.05）.
Conclusion
Comprehensive care obtains a definite effect in the nursing of chronic sinusitis with endoscopic surgery.It can increase patient′s compliance,alleviate pain,relieve physical and psychological stress,and reduce complications with high nursing satisfaction from patients.
2018 Vol. 25 (26): 189-191 [
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120
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192
Impact of health education and dietary care on pregnancy outcomes in pregnant women with gestational diabetes mellitus
XU Wei-li
Objective
To investigate the effect of health education and dietary care on pregnancy outcomes in pregnant women with gestational diabetes mellitus (GDM).
Methods
A total of 90 pregnant women with GDM from February 2016 to June 2017 were enrolled in our hospital.They were equally divided into two groups using a random number table method,45 cases in each group.In control group,routine care was used,while in observation group,health education and dietary care were added on the basis of the control group.Satisfaction with nursing services,mastery of DM knowledge during pregnancy,treatment compliance,compliance with dietary advice in the two groups were compared.The blood glucose monitoring indicators in these participants including fasting blood glucose(FBG),postprandial 2-hour blood glucose(2 hBG),and glycosylated hemoglobin(GHb)before and after intervention were also compared.Besides,the incidence of adverse gestational events was compared.
Results
The satisfaction by pregnant women with GDM in the observation group was higher than that of the control group (P＜0.05）.The mastery of GDM knowledge,treatment compliance,and compliance with dietary advice were all higher in the observation group than in the control group with statistical significance (P＜0.05）.Before intervention,there was no significant difference in FBG， 2 hBG,or GHb between the two groups(P＞0.05）.After nursing intervention,these three indicators were,lower in the observation group compared with those in the control group with statistical significance (P<0.05）.The incidence of adverse pregnancy events in the observation group was lower than that in the control group with a significant difference (P<0.05）.
Conclusion
Health education and dietary nursing have positive impacts on the pregnancy outcomes in pregnant women with GDM.They both can enhance the awareness of pregnant women on DM,willingly increase the treatment compliance and reasonable dietary behavior,effectively control blood glucose,and improve pregnancy outcomes with high satisfaction on nursing services by pregnant women,which is worthy of promotion.
2018 Vol. 25 (26): 192-194 [
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121
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195
Application effect of psychological nursing intervention in maintenance hemodialysis patients
WANG Hong;WEI Jia;ZHANG Jing;SUN Li-xin;WU Shuang;HOU Li-hua
Objective
To investigate the application effect of psychological nursing intervention in maintenance hemodialysis(MHD)patients.
Methods
A total of 248 patients with chronic renal failure (CRF)who received MHD treatment in our hospital from June 2015 and January 2017 were randomly divided into intervention group and control group,124 cases in each group.The self-rating anxiety scale (SAS)and the self-rating depression scale (SDS)were used to assess the patient′s psychological state before first MHD after being admitted to hospital and being discharged.The treatment compliance was observed.
Results
Before intervention,there was no significant difference in SAS or SDS score between the two groups(P＞0.05）.After the intervention,both SAS and SDS scores significantly decreased,and the SAS and SDS scores in the intervention group were significantly lower than those in the control group,with statistical significance(P<0.01）.The treatment compliance of the intervention group was better than that of the control group(P<0.01）.
Conclusion
The implementation of psychological nursing intervention in MHD patients can improve their emotional and health status,as well as patient′s treatment compliance.
2018 Vol. 25 (26): 195-197 [
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136
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198
Efficacy of emotional nursing therapy in patients with negative symptoms of schizophrenia
CAO Yun-zhen;CHEN Ze-qun;HUANG Ju-juan;WEI Chang-shu
Objective
To explore the application effect of emotional nursing therapy in patients with negative symptoms of schizophrenia.
Methods
A total of 92 patients with negative symptoms of schizophrenia admitted in our hospital from January 2017 to January 2018 were selected and divided into control group and observation group according to different therapies,46 cases in each group.The control group was received basic care,and the observation group was received emotional care therapy.The final treatment effect were comparred.
Results
After intervention,the total effective rate of nursing in the observation group(97.83%)was higher than that of the control group(84.78%),the difference was statistically significant(P<0.05）.The satisfaction degree of patients and family members in the observation group(95.65%)was higher than that of the control group (80.43%),the difference was statistically significant(P<0.05）.Before the nursing intervention,there was no statistically significant difference in emotions,lack of will,poor thinking,social lack of interest,and attention deficit scores between the two groups of patients.(P＞0.05）.After the nursing intervention,the scores of the SANS scales of the two groups were significantly lower than before the intervention,the scores of the SANS scale of the observation group were significantly lower than of the control group,and the differences were statistically significant(P<0.05）.
Conclusion
The effect of emotional nursing on schizophrenia patients with negative symptoms is significant.It can effectively improve nursing efficiency and satisfaction,relieve negative symptoms of patients,improve quality of life,and has high clinical value.
2018 Vol. 25 (26): 198-200 [
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123
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201
Application effect of perioperative nursing in the patients with isolated kidney ureteral calculi
JIANG Juan
Objective
To investigate the application effect of perioperative nursing in the patients with isolated kidney ureteral calculi.
Methods
A total of 69 patients with isolated kidney ureteral calculi who were admitted to our hospital from December 2016 to November 2017 were selected as the study subjects.All patients were given ureteroscopic surgery.According to the perioperative nursing methods,the patients were divided into two groups：observation group(36 cases)and control group(33 cases).The control group was given routine nursing pathway.The observation group was given perioperative nursing intervention on this basis.The complication rate and nursing satisfaction were compared between the two groups.
Results
The complication rate and satisfaction in the patients in the observation group were 8.33%and 97.22%respectively.The complication rate and nursing satisfaction in the control group were 36.36%and 78.79%respectively.The differences between groups were statistically significant(P＜0.05）.
Conclusion
During ureteroscopic surgery for isolated ureteral calculi,perioperative nursing intervention can reduce the incidence rate of complications,and promote the improvement of therapeutic effects,which has a positive effect on its prognosis and is worthy of promotion and application in clinical practice.
2018 Vol. 25 (26): 201-202转205 [
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107
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203
Application effect of continuous nursing in postpartum care in puerperae
WU Xiao;XIA Jing-ju;DING Si-yue;HAN Li-rong;MENG Xiu-chun;WANG Hai-li
Objective
To explore the effect observation of continuous nursing on postpartum care in puerperae.
Methods
A total of 300 puerperae admitted to our hospital from May 2016 to July 2017 were selected as study subjects.They were equally divided into two groups according to the envelop randomization,150 cases in each group.In the regular group,participants were discharged from the hospital as usual,while in the experimental group,continuous nursing was provided after discharge.The self-care ability，postpartum depression score and social support score of the two groups were compared.
Results
The self-care ability of the experimental group was significantly better than that of the regular group (P＜0.05）.The postpartum depression score of the experimental group was significantly lower than that of the regular group.The incidence of mastitis and infection was significantly lower than that of the regular group (P＜0.05）.The social support score of the experimental group was significant higher than that in the regular group,the differences were statistically significant(P<0.05）.
Conclusion
Continuous nursing as an intervention for puerperae can facilitate their self-care ability,improve their postpartum depression as well as their post-natal quality of life,which is worth adopting.
2018 Vol. 25 (26): 203-205 [
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122
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206
Clinical effect of integrated TCM nursing intervention on infertile patients with premature ovarian failure
MA Hong-xia;XING Jin-ling
Objective
To study the clinical effect of integrated traditional Chinese medicine(TCM)nursing intervention on infertile patients with premature ovarian failure.
Methods
A total of 64 infertile women with premature ovarian failure from May 2017 to February 2018 in our hospital were selected.By the random number table method,they were equally divided into control group and observation group,32 cases in each group.In the control group,routine nursing was used,while in the observation group were provided with integrated TCM nursing intervention.The clinical indicators,nursing satisfaction and quality of life after nursing were compared between the two groups.
Results
Estradiol(E
2
)and anti-Mullerian hormone(AMH)were(74.64±6.18)pmol/L and(2.47±3.29)ng/mL in the observation group,both higher than those in the control group,(53.96±7.13)pmol/L and (1.53±0.36)ng/ml with statistical significance (P＜0.05）.The follicle stimulating hormone (FSH)in the observation group was (34.26±3.97)U/L,lower than that in the control group of(46.65±3.81)U/L,with a significance difference(P＜0.05）.In the observation group,the scores of physiological function,psychological function,social function and dietary function were(89.72±1.26),(89.28±4.36),(91.37±1.42),and(92.63±1.35)point,all higher than those in the control group(78.47±2.63),(80.65±3.27),(79.72±2.48),and(81.28±1.59)point accordingly with statistical significance(P＜0.05）.
Conclusion
Integrated TCM nursing can effectively improve the clinical efficacy of infertility patients with premature ovarian failure,ameliorate the quality of life,and speed up the recovery of ovarian function.
2018 Vol. 25 (26): 206-208 [
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104
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209
Application effect of systematic nursing intervention in children with hand-foot-mouth disease
AI Li
Objective
To explore the application effect of systematic nursing intervention in children with hand-footmouth disease(HFMD).
Methods
A total of 98 cases of HFMD in our hospital from April 2016 to January 2018 were selected and divided into the control group and the observation group according to the order of admission,49 cases in each groups.The control group was received routine nursing intervention,and the observation group was received systematic nursing intervention on the basis of the control group.The symptoms improvement time,hospitalization time and family care satisfaction of two groups were statistically recorded.
Results
In the observation group,the time of antipyretic use,oral ulcer healing,vesicle scab,rash subsided and hospitalization time were shorter than those in the control group,and the differences were statistically significant(P＜0.05）.Compared with the control group 77.55%,the total satisfaction of the observation group was 95.92%,and the difference was statistically significant(P＜0.05）.
Conclusion
Systematic nursing intervention can shorten the improvement time of clinical symptoms and hospitalization time of HFMD children,and improve nursing satisfaction.
2018 Vol. 25 (26): 209-211 [
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104
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Application effect of traditional Chinese medicine nursing intervention in patients with senile femoral neck fracture after artificial femoral head replacement
ZHANG Feng-hua;CAO Shao-juan;TIAN Hong
Objective
To explore the clinical effect of traditional Chinese medicine nursing intervention in the treatment of senile femoral neck fracture after artificial femoral head replacement.
Methods
A total of 56 patients with artificial femoral head replacement in our hospital from January 2016 to January 2018 were selected and were rondomly divided into the observation group and the control group,28 cases in each group.The control group was given conventional nursing intervention,while the observation group was given the nursing intervention of Traditional Chinese Medicine.Hip joint harris score,incidence of postoperative complications and nursing satisfaction were compared between two groups.
Results
Hip joint harris score and the nursing satisfaction in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05）.Incidence of postoperative complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05）.
Conclusion
Application of Traditional Chinese Medicine nursing intervention during perioperative period for patients with bone arthroplasty is beneficial to reduce the incidence of postoperative infection and improve nursing effect,which is worthy of practice and promotion.
2018 Vol. 25 (26): 212-214 [
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127
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Effect of collaborative nursing mode on negative emotion and quality of life in patients with myocardial infarction during convalescence
ZHU Jian;XIONG Xiao-yun;WAN Wen-ting;TU Hui1GUO Ting;YANG Jin-hua;ZHAI Hui-lan
Objective
To analyze the effect of collaborative nursing mode on negative emotion and quality of life in patients with myocardial infarction during rehabilitation.
Methods
Altogether 102 cases of myocardial infarction treated in our hospital from August 2016 to July 2017 were selected and divided into observation group(single sequence number)and control group (double sequence number)according to the serial number,51 cases in each group.The control group was received routine nursing;while,the observation group was adopted the collaborative nursing mode.The negative emotions and quality of life of the two groups before and after nursing were compared.
Results
Before nursing,there was no statistically significant difference in the scores of negative emotion and quality of life between the two groups(P＞0.05）;after nursing,the score of negative emotion of the observation group was significantly lower than that of the control group (P<0.05）;the score of quality of life of the observation group was significantly higher than that of the control group,the differences were statistically significant(P<0.05）.
Conclusion
Collaborative nursing mode can effectively improve the negative emotion and quality of life of patients with myocardial infarction during rehabilitation.
2018 Vol. 25 (26): 215-217 [
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125
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Application effect of high quality nursing service in elderly patients with silicosis
ZHANG Yong-yan;ZHANG Hai-qiong
Objective
To explore the effect of high-quality nursing care in elderly patients with silicosis.
Methods
From October 2016 to October 2017,78 elderly silicosis patients treated in Department of Respiratory Medicine in our hospital were selected as study objects.According to the order of the patients were randomly divided into the experimental group and the reference group,39 patients in each group.The patients in the reference group were given routine nursing intervention,and the patients in the experimental group were given high quality nursing service.The quality of life and nursing satisfaction were compared between the two groups.
Results
After nursing intervention,all areas scores and total scores of quality of life in the experimental group were significantly higher than those in the control group,the differences were statistically significant(P<0.05）.The total satisfaction of the patients in the experimental group was 92.31%,which was significantly higher than that in the control group(79.49%),and the difference was statistically significant(P<0.05）.
Conclusion
The application of high quality nursing service can obviously improve the clinical symptoms,improve the quality of life and nursing satisfaction of the elderly patients with silicosis,and is worthy of extensive clinical application.
2018 Vol. 25 (26): 218-220 [
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