丙氨酸氨基转移酶（ALT）检测在血液筛查中的价值研究

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Abstract Objective To study the relationship between alanine aminotransferase (ALT)and hepatitis A virus(HAV)and hepatitis G virus(HGV)and to evaluate its value in blood screening.Methods Blood samples from unpaid blood donors in Zhaoqing area from January to December 2017 were randomly collected,and five bloods transfusion tests(hepatitis B virus surface antigen[HBsAg],hepatitis C virus antibody[Anti-HCV],human immunodeficiency virus antibody[Anti-HIV],syphilitic spirulina[TP],human T lymphocytic leukemia virus[Anti-HTLV])were negative.Altogether 874 specimens with normal ALT(ALT≤50 U/L)were used as control group(393 specimens were used as the control group 1,and 481 specimens were used as the control group 2),and 135 specimens with abnormal ALT (ALT>50 U/L)were used as study group.Five blood transfusion infections were detected by nucleic acid detection technology(NAT)and enzyme-linked immunosorbent assay (ELISA).ALT was detected by rate method,and HAV-IgG and HGV-IgG were detected by ELISA.The blood samples from unpaid blood donors in Zhaoqing City from 2003 to 2017 were retrospectively analyzed.The abnormal rate of ALT in HbsAg positive blood donors (2216 cases)and Anti-HCV positive blood donors(664 cases)was investigated.Results HAV-IgG was detected both in the control group 1 and in the study group,352 cases(89.6%)were positive in the control group,and 110 cases(81.5%)were positive in the study group.The positive rate of HAV-IgG in the study group was lower than that in the control group 1,and the difference was statistically significant(P<0.05).The positive rate of HGV-IgG in the control group 2 and in the study group was 0.0%.There were 109 cases(4.9%)of ALT abnormalities in 2216 HBsAg-positive cases and 161 cases(24.2%)of ALT ab-normalities in 664 Anti-HCV-positive cases.The abnormal rate of ALT in HBsAg-positive cases was lower than that in Anti-HCV-positive cases,and the difference was statistically significant(P<0.05).Conclusion ALT is related to HCV,but after the specific test of ELISA and NAT,ALT test is no longer helpful to improve the residual risk of HCV.The positive rate of HAV-IgG in the study group is lower than that in the control group,but HAV is a non-bloodborne disease and did not help to improve the residual risk of blood safety.

Key words： Alanine aminotransferase Blood donors Blood screening Residual risk

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	Articles by authors
	LI Jie-min
	CHEN Zhi-zhong
	CHEN Shang-liang
	LIAO Yang-xun
	YU Wen-chao
	LU Shao-fen
	LIANG Jianfeng
	LI Xun-wei

Cite this article:

LI Jie-min,CHEN Zhi-zhong,CHEN Shang-liang, et al. Value of Alanine Aminotransferas in blood screening[J]. 中国当代医药, 2018, 25(26): 158-160转178.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I26/158

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