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Quick Search     Adv Search 2018 Vol. 25, No. 23 Published: 2018-08-18   4 Optimization of water extraction technology of Shiwei Ehuang Granules by multi-index comprehensive evaluation method LUO Yu-dong;ZHU Zhi-de;TAN An-qiang;LU Shi-heng;LI Fang-chan Objective To study the optimization and quality control of water extraction process of Shiwei Ehuang Granules.MethodsAstragaloside A,Magnolin,Saikosaponin A and total extract of Shiwei Ehuang Granules were taken as the indexes and comprehensive evaluation.The orthogonal design was applied to investigate the effect of water addition,water extraction times and boiling time on the product water extraction process,and to determine the optimal water extraction process for Shiwei Ehuang Granules.Results The optimum water extraction process of Shiwei Ehuang Granules was to add 14 times the amount of water to the medicinal materials,and decoct three times for 1 h each time.The average content of Astragaloside A,Saikosaponin A,and Magnolia extracted from dry paste extracted by this process was respectively 5.78,1.78 and 3.30 mg/g,and RSD was 1.56%,2.77%and 0.61% (n=3).Conclusion The optimized water extraction process of Shiwei Ehuang Granules has good reproducibility and stable quality,and is suitable for mass production.Therefore,the water extraction process is reasonable and feasible. 2018 Vol. 25 (23): 4-07 [Abstract] ( 151 ) HTML (43 KB)  PDF  (0 KB)  ( 22 ) 8 Optimization of the secondary reflux extraction process of Schisandrae Chinensis Fructus by central composite design-response surface methodology YE Yin-yin;LI Yan;LI Zi-hang;CAO Zhi-qi Objective To optimize secondary extraction processes of Schisandrae Chinensis Fructus through the central composite design-response surface methodology.Methods The content of lignan was determined by Ultraviolet spectrophotometry at the wavelength of 278 nm.The content of lignin as dependent variable,ethanol concentration,extraction time and solvent times as independent variables,the secondary extraction processes of Schisandrae Chinensis Fructus was optimized by central composite design-response surface methodology.Results The first extraction process was optimized as follow:extracted Schisandrae Chinensis Fructus for 70 min with 10 times,the amount of crude drugs and the volumes of 70%ethanol.The binomial fitting complex correlation coefficient was r=0.8900,and the actual value of extraction ratio was larger than the predicted.The second extraction process was optimized as follow:extracted Schisandrae Chinensis Fructus for 40 min with 10 times the amount of crude drugs and the volumes of 70%ethanol.The correlation coefficient of binomial fitting was r=0.8445.The average value of lignans obtained from the verification test was 8.953 mg/g,and the deviation between the true value and the predicted value was 2.0%.Conclusion The central composite design-response surface methodology is preferred,and the obtained Schisandra extraction process has good predictability,shortens the extraction time,and reduces the production cost. 2018 Vol. 25 (23): 8-12 [Abstract] ( 136 ) HTML (51 KB)  PDF  (0 KB)  ( 34 ) 13 Analysis of application effect of monitoring Fluorouracil blood concentration to guide the individualized treatment of gastric cancer ZHOU Lin-ping;LIU Qiao-zhen Objective To explore the significance of the combined chemotherapy in guiding individualized treatments of advanced gastric cancer,and to observe its association with both the efficacy and toxic and adverse effects by monitoring and regulating the concentration of Fluorouracil in patients′peripheral blood.Methods A total of 40 patients with stageⅢ-Ⅳ gastric cancer from June 2015 to May 2017 in our hospital were selected as objects and randomly divided into the control group and the experimental group,with 20 cases in each group.The two groups were treated with Oxaliplatin combined with Capecitabine for first line chemotherapy,at least 4 cycles and above.In the first cycle,all patients were given drugs in the traditional body surface area (BSA)manner.From the beginning of the second cycle to the end of chemotherapy,the control group still was given the way of BSA administration,while in the experimental group,the drug dose of Fluorouracil for the post-chemotherapy cycle was adjusted according to the plasma drug concentration of Fluorouracil and the pharmacological parameters of Fluorouracil obtained in the first cycle of chemotherapy.The efficacy and safety of two groups were compared.Results The blood target concentration of Fluorouracil in patients was 200-250 ng/ml.The concentration of Fluorouracil in patients of the experimental group was basically adjusted to the steady state during the fourth cycle of chemotherapy,which was 200-250 ng/ml,in the control group,only 5%of the patients reached the target concentration,and the difference was statistically significant(P＜0.05).The incidence of myelosuppression and hand-foot syndrome in the experimental group were significantly superior to those of the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of gastrointestinal reactions,diarrhea,and mucositis between two groups(P＞0.05).The total reaction rate of the experimental group was 65.00%,which was significantly higher than that in the control group (25.00%),and the difference was statistically significant(P＜0.05).The PFS and OS of the experimental group were 13.5 and 8.5 months,which were respectively longer than that in the control group(10.0 and 6.0 months),and the differences were statistically significant(P＜0.05).Conclusion In patients with advanced gastric cancer treated with Oxaliplatin combined with Capecitabine chemotherapy,patients with Fluorouracil steady state blood concentration maintained 200-250 ng/ml are well tolerated and have better survival benefit. 2018 Vol. 25 (23): 13-16 [Abstract] ( 125 ) HTML (40 KB)  PDF  (0 KB)  ( 29 ) 17 Effect of high-intensity focused ultrasound in the treatment of allergic rhinitis and its influence on immune function in patients QIU Wen-tao;CHEN Xiang-wei Objective To investigate the clinical effect of high intensity focused ultrasound in the treatment of allergic rhinitis and its influence on the IL-2,IL-4,IL-10,IFN-γ and histamine content.Methods Fifty patients with AR treated by Otolaryngology Department of Chaozhou Central Hospital from June 2013 to December 2016 were selected as the research group and 30 healthy people were selected as the control group at the same period.The symptom score,the results of the nasal resistance before and 6 months after treatment in patients of the research group were compared,while the IL-2,IL-4,IL-10,IFN-γ and histamine content in the research group before treatment and after 6 months treatment were compared with those in the control group.Results Each symptom score before treatment and after 6 months treatment in the research group were compared with significant differences(P＜0.05).The efficacy index showed that 38 cases were effective at 6 months after treatment,8 cases were effective and 4 cases were ineffective,and the total effective rate was 92.0%.The Reffin,Reffex,VRin and VRex in the study group after 6 months treatment were significantly lower than those before treatment(P＜0.05).The IL-4,IL-10,histamine content before and 6 months after treatment in the study group were significantly higher than those in the control group,while the IL-2 and IFN-γ content in the study group were significantly lower than those in the control group,and the differences were statistically significant(P＜0.05).The IL-4,IL-10 and histamine content 6 months after treatment in the study group were significantly lower than those before treatment,and the differences were statistically significant(P＜0.05).There was no significant difference in the IL-2 and IFN-γ content 6 months after treatment in the study group compared with those before treatment(P＞0.05).Conclusion High intensity focused ultrasound in the treatment of allergic rhinitis can improve nasal mucosa responsiveness and hypersensitivity in patients with a better clinical effect. 2018 Vol. 25 (23): 17-20 [Abstract] ( 168 ) HTML (44 KB)  PDF  (0 KB)  ( 23 ) 21 Meta-analysis of effect of topical oxygen therapy treating neonatal diaper dermatitis YE Xin-xin;ZHAN Chen-ju;LIU Qi-xi;ZENG Lin-miao;XU Zhong-bo Objective To systematically evaluate the effect of topical oxygen therapy treating neonatal diaper dermatitis.Methods The Cochrane Library,PubMed,Embase,China Biomedical Database,China Knowledge Database,VIP Database and Wanfang Database were searched.The search date was from database construction to June 2017.Randomized controlled trials of topical oxygen therapy or topical oxygen therapy combined with other treatments treating neonatal diaper dermatitis were collected.After evaluating the quality according to the Cochrane manual 5.1.0,literature data were extracted and Meta analysis was performed using RevMan 5.3 software.Results A total of 16 randomized controlled trials were included in,and there were 2317 patients.The results of Meta-analysis show that:in terms of the total effective rate,topical oxygen therapy or topical oxygen therapy combined with other treatments methods was significantly better than other treatments with a significant difference(OR=9.07,95%CI[6.01,13.70],P＜0.00001);in the healing time,topical oxygen therapy or topical oxygen therapy combined with other treatments methods was significantly better than other treatments with a significant difference (MD=-1.96,95%CI[-2.85,-1.06],P＜0.00001);in terms of satisfaction degree,one study suggested that the satisfaction rate of pediatric patients and nursing staff in the local oxygen therapy group was higher than that of control group;in adverse reactions,it did not increase the occurrence of adverse reactions.Conclusion Existing research shows that application of topical oxygen therapy can improve the total effective rate of treating,shorten the healing time,increase the satisfaction degree of pediatric patients and nursing staff,and it does not increase the occurrence of adverse reactions. 2018 Vol. 25 (23): 21-25 [Abstract] ( 145 ) HTML (50 KB)  PDF  (0 KB)  ( 33 ) 26 Meta-analysis of the correlation between P-AKT protein expression and cervical cancer risk LI Xiu-ling;FU Qiang;GAO Tian-ming;YANG Dan-he;CONG Li-li;WANG Jun-wen Objective To systematically evaluate the correlation of P-AKT protein expression with cervical cancer and its different clinicopathological features.Methods The Cochrane Library,EMBase,PubMed,VIP,Duxiu,Wanfang and China National Knowledge Internet were retrieved by computer.Case randomized controlled study officially published on the relationship between P-AKT expression and cervical cancer and its clinicopathological features were searched.The search date was from database construction to December 2017.After data were extracted and evaluated its quality,RevMan 5.3 software was used for meta-analysis.Results A total of 9 studies including 1050 participants were included,there were 421 cases patients with cervical cancer,434 patients with cervical intraepithelial neoplasia (CIN),and 195 women with normal cervix.Meta-analysis showed that:①there were significant differences in the expression of PAKT between cervical cancer and normal cervix group(OR=25.79,95%CI[11.14,59.70],P＜0.00001),cervical cancer and CIN group(OR=4.98,95%CI[3.55,7.00],P＜0.00001),and CIN and normal cervix group(OR=6.53,95%CI[4.14,10.29],P＜0.00001).② the expression of P-AKT in cervical cancer with lymph node metastasis group and non-metastasis of lymph node group(OR=3.38,95%CI[1.60,7.17],P=0.001)was statistically significant,however,there was no great difference was detected between poorly differentiated cervical cancer and moderately-highly differentiated group(OR=1.03,95%CI[0.49,2.18],P=0.93)or between clinical phaseⅡof International Federation of Gynecology and Obstetrics(FIGO)between cervical cancer group and phase I of FIGO in cervical cancer group(OR=2.09,95%CI[0.90,4.85],P=0.09).Conclusion The expression of P-AKT protein has significant correlation with cervical cancer and it is a potential diagnostic and prognostic indicator of cervical cancer. 2018 Vol. 25 (23): 26-29 [Abstract] ( 132 ) HTML (43 KB)  PDF  (0 KB)  ( 31 ) 30 Relationship between blood pressure variability and target organ damage LI Ke;WANG Li;LIU Jian-xiong Hypertension is a risk factor for many cardiovascular diseases.In some patients with well-controlled blood pressure,damages of target organs and cardiovascular adverse events may still occur.In 2013,ESC proposed that blood pressure variability should become a new important target in the field of blood pressure control.Hypertension is a risk factor for various target organ damages such as heart,brain and kidney.Blood pressure variability is a new target for the management of hypertension,and further control of blood pressure variability will effectively reduce the damage rate of important target organs throughout the body,as well as reduce the incidence rates of diseases including renal insufficiency,stroke,cognitive decline,ventricular hypertrophy,heart failure,arrhythmia,peripheral arteriosclerosis,and coronary heart disease. 2018 Vol. 25 (23): 30-33 [Abstract] ( 145 ) HTML (45 KB)  PDF  (0 KB)  ( 30 ) 34 Research progress on etiology,pathogenesis and treatment of acne in traditional Chinese medicine CHEN Yong;LIU Gui-hua Acne is a common chronic inflammatory skin lesion occurring in the sebaceous glands of the hair follicle.The traditional Chinese medicine literature related to acne was retrieved from the data base such as China national knowledge internet(CNKI)and Wan Fang,and then was summarized.The understanding of the etiology,pathogenesis and treatment of acne from the perspective of traditional Chinese medicine was discussed.It is found that according to the traditional Chinese medicine,the pathogenesis of acne not only has the factors of congenital endowment,but also is related to factors such as the spleen and stomach and phlegm dampness.The traditional Chinese medicine considers the pathogenesis of acne mainly from the syndrome differentiation of the viscera,but with different emphasis.The external treatment of TCM is used in modern clinical practice including blood-letting puncture,cupping,catgut implantation at acupuncture point and Chinese medicine mask,which has accurate effectiveness. 2018 Vol. 25 (23): 34-36转41 [Abstract] ( 141 ) HTML (39 KB)  PDF  (0 KB)  ( 32 ) 37 Research progress of the relationship between intestinal barrier function and disease occurrence LI Rui;LI Xiao-shuang;GUI Chun-shuang;REN Mei-ling;WANG Jia-yi Intestinal barrier is one of the most important physical protection of the human beings.Abundant clinical and laboratorial researches reveal that destruction or debilitation of intestinal barrier may lead to bacterial translocation.Many physical symptoms such as endotoxin,D-lactate and diamine oxidase may change,which are related to vairous occurrence of diseases.Systemic inflammatory response syndrome (SIRS),even multiple organ dysfunction syndrome(MODS),may happen in serious situation.This paper elaborates the structure and function of the intestinal barrier,explain its mechanism of protection and inflammation.Diseaseas related with intestinal barrier are enumerated in detail.The review further shows that thedetection of intestinal barrier may play an important role in the prevention and paroxysm of serious diseases. 2018 Vol. 25 (23): 37-41 [Abstract] ( 152 ) HTML (52 KB)  PDF  (0 KB)  ( 32 ) 42 Research progress of the relation between miRNA and ischemic stroke WEI Qi;QIN Shao-dong microRNAs(miRNAs)are a class of non-coding,short-structured,single-stranded RNAs that regulate gene expression after transcription by binding to the mRNA3′translation region of the target gene.They are not only involved in regulating almost all biological processes,but also associate with the occurrence and development of many diseases.The study of the mutual expression of miRNAs and their target genes is helpful to further understand the mechanism and function of miRNAs.This article reviews present studies on the relationship between miRNA and ischemic stroke. 2018 Vol. 25 (23): 42-46 [Abstract] ( 155 ) HTML (52 KB)  PDF  (0 KB)  ( 20 ) 47 Diagnostic value of pleural effusion and blood γ-interferon release test in patients with tuberculous pleurisy ZENG Jun;WANG Guang-ming;WU Ben-qing;WANG Gang;ZHANG Run-ling;TANG Dong-e;DAI Yong;ZHU Peng Objective To investigate the diagnostic value of pleural effusion and blood γ-interferon release test(IGRA)in patients with tuberculous pleurisy.Methods A total of 151 patients with pleural effusion from January to December 2016 in Shenzhen People′s Hospital were selected and divided into tuberculous pleurisy group (77 cases)and non-tuberculous pleurisy group(74 cases)according to clinical diagnosis.Blood and pleural effusion samples of the patients were collected respectively to carry out IGRA.The sensitivity,specificity,negative predictive value,positive predictive value and consistency of the results of the tests on blood and pleural effusion samples were analyzed by using statistical software.Results The sensitivity of the pleural effusions IGRA was 97.4%and the specificity was 73.1%.The sensitivity of the blood was 83.1%，the specificity was 87.7%,and the sensitivity of the pleural effusion was higher than that of the blood(χ2=8.94,P＜0.05),but the specificity was less than the blood(χ2=4.74,P＜0.05).The positive predictive value of the pleural effusions IGRA was 80.6%,and the negative predictive value was 96.1%.Blood IGRA positive predictive value was 87.7%,negative predictive value was 83.1%,the pleural effusions positive predictive value compared to the blood,there was no statistically significant difference(χ2=1.48,P＞0.05),and the pleural effusions negative predictive value was higher than the blood (χ2=4.98,P＜0.05).The consistency of two samples was not good (Kappa=0.57).Conlusion The pleural effusion and blood γ-interferon release test had a certain diagnostic value in tuberculous pleurisy.The pleural effusionγ-interferon release test was more meaningful for the differential diagnosis of tuberculous pleurisy. 2018 Vol. 25 (23): 47-49转66 [Abstract] ( 145 ) HTML (40 KB)  PDF  (0 KB)  ( 25 ) 50 Clinical efficacy and safety of tirofiban in patients with acute cerebral infarction undergoing stenting LI Bing-run;LUO Sai-hua;JIANG Qing-yan Objective To investigate the clinical efficacy and safety of tirofiban in patients with acute cerebral infarction undergoing stenting.Methods The clinical data of 31 patients with acute cerebral infarction admitted to our hospital from January 2016 to November 2017 who were treated with tirofiban during stenting were retrospectively analyzed.according to whether tirofiban was used during the operation,they were divided into control group (12 cases)and observation group (19 cases).The control group was treated with stenting alone,while the observation group was treated with tirofiban during stenting.The platelet aggregation level,nihss and bi scores and the incidence of adverse reactions were compared between the two groups before and after treatment.Results Before treatment,there was no significant difference in platelet aggregation between the two groups (P＞0.05).The platelet aggregation level of 24 h was significantly lower than that before treatment in two groups,and the platelet aggregation level in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).Before surgery,there was no significant difference in NIHSS score and BI score between the two groups.At 3 weeks after surgery,the NIHSS scores of the two groups were lower than those before surgery,and the BI scores of the two groups were higher than those before surgery 3 months after surgery,the difference was statistically significant(P＜0.05).NIHSS scores in the observation group were lower than those in the control group 3 weeks after surgery,and BI scores were higher than those in the control group 3 months after surgery,the difference was statistically significant(P＜0.05).There was 1 case of symptomatic bleeding in the control group,1 case of asymptomatic bleeding in the study group,and no death.There was no statistical difference in the incidence of intracranial hemorrhage between the two groups after treatment(P＞0.05).Conclusion Tirofiban can reduce platelet aggregation rate,improve vascular recanalization rate,improve the prognosis of patients with acute cerebral infarction during stenting,and has high safety. 2018 Vol. 25 (23): 50-52 [Abstract] ( 157 ) HTML (37 KB)  PDF  (0 KB)  ( 29 ) 53 Timing and method of endotracheal intubation for critically ill comatose patients in emergency department of internal medicine ZHENG Min-wei Objective To explore the timing and method of endotracheal intubation for critically ill comatose patients in emergency department.Methods Seventy-six critically ill comatose patients who received endotracheal intubation in our emergency department from January 2017 to January 2018 were selected as the research objects,and divided into immediate group (n=39)and delayed group (n=37)according to the intubation timing.In the immediate group,the emergency medical staff immediately underwent endotracheal intubation,while in the delayed group,after the anesthesiologists arrived in the emergency medical department,they underwent endotracheal intubation.The time from preparation to intubation,the time required for intubation,the success rate of endotracheal intubation,the success rate of rescue and the survival rate within one month were compared between the two groups.Results There was no statistical difference between the two groups(P＞0.05).The time from preparation to intubation in the immediate group was shorter than that in the delayed group,the difference was statistically significant(P＜0.05).There was no statistical difference between the two groups(P＞0.05).There was no statistically significant difference in the success rate of tracheal intubation between the two groups(P＞0.05).The success rate of rescue and survival rate within one month in the immediate group were significantly higher than those in the delayed group,and the difference was statistically significant(P＜0.05).Conclusion For critically ill patients in emergency department,endotracheal intubation as soon as possible based on the specific conditions of the patients can improve the success rate of rescue and reduce the occurrence of death rate. 2018 Vol. 25 (23): 53-55 [Abstract] ( 123 ) HTML (34 KB)  PDF  (0 KB)  ( 29 ) 56 Follow-up study of continuous positive airway pressure in obstructive apnea-hypopnea syndrome ZHU Ying-ying;CHEN Qiao-ling;ZHU Ji-peng;LI Xin;GUO Wen-xian Objective To observe the changes of blood biochemical parameters,blood pressure and Epworth scale scores in patients with obstructive sleep apnea-hypopnea syndrome after continuous positive airway pressure therapy,so as to evaluate the clinical efficacy of continuous positive airway pressure therapy.Methods A total of 100 patients with obstructive sleep apnea hypopnea syndrome admitted to our hospital from January 2015 to January 2016 were selected.Finally,92 cases were included.By a random number table method,they were divided into treatment group(n=47)and control group(n=45).In the treatment group,continuous positive pressure ventilation was adopted,and the observation period was 30 days.In the control group,routine symptomatic treatment was used.After the end of the observation period,the blood lipids,C-reactive protein(CRP),homocysteine(HCY),and red blood cell distribution width level,blood pressure,and Epworth score improvement were observed and compared in the two groups.Results There was no significant difference in the levels of low density lipoprotein(LDL)and total cholesterol(TC)before treatment between the two groups(P＞0.05).After treatment,the TC level and the distribution width of red blood cells in the treatment group were lower than those before treatment with statistical differences(P＜0.05).Before and after treatment,there was no significant difference in the levels of LDL,hs-CRP and HCY in the treatment group(P＞0.05).After treatment the TC level and the distribution width of red blood cells in the treatment group were lower than those in the control group with significant differences(P＜0.05).After treatment,the systolic blood pressure in the treatment group was lower than that before treatment(P＜0.05).There was no statistical difference between the diastolic blood pressure levels before and after treatment in the treatment group and those before treatment in this group(P＞0.05).Before treatment,there was no statistically significant difference in blood pressure between the two groups(P＞0.05).There was no statistically significant difference between the blood pressure levels of the control group before and after treatment(P＞0.05).There was no significant difference in Epworth sleepiness scale scores between the two groups before treatment(P＞0.05).The scores of Epworth sleepiness scale after treatment in the treatment group were lower than those before treatment in this group,and the scores of Epworth sleepiness scale after treatment in the treatment group were lower than those in the control group,the difference was statistically significant(P＜0.05).There was no statistically significant difference between the two groups before and after treatment (P＞0.05).Conclusion Continuous positive pressure ventilation obtains good effects on blood pressure control,improvement of myocardial ischemia,lipid metabolism and quality of life in patients with obstructive apnea-hypopnea syndrome. 2018 Vol. 25 (23): 56-59 [Abstract] ( 152 ) HTML (42 KB)  PDF  (0 KB)  ( 26 ) 60 Effect of different ventilation modes on lung injury in patients performed with retroperitoneal laparoscopic surgeries LA Jin;TIAN Shou-yuan;WANG Xin;SU Xue-sen;YUAN Xin;ZHANG Rui;LIU Shu-fang;LI Chao Objective To compare the influence of pressure control ventilation–volume guaranteed (PCV-VG)and volume controlled ventilation (VCV)on lung injury in patients performed with retroperitoneal laparoscopic surgeries.Methods From August to December 2017,60 patients performed with retroperitoneal laparoscopic surgeries in our hospital were selected.They were divided into two groups by a random double-blinding:PCV-VG group (Pgroup)and VCV group (Vgroup)with 30 cases in each group.Ventilation was carried out based on the preset ventilation parameters.At T1-T4(5 min after tracheal intubation,30 min after pneumoperitoneum,90 min after pneumoperitoneum,and 30 min after pneumoperitoneum ending),the Ppeak,Pmean,and end-tidal carbon dioxide(PetCO2)were recorded,lung compliance at various times(Cd)was calculated,and the concentrations of plasma interleukin-6(IL-6),tumor necrosis factor-α (TNF-α),and soluble intercellular cell adhesion molecule-1 (sICAM-1)were monitored at each time by drawing arterial blood.The changes of respiratory mechanics parameters and the concentrations of IL-6,TNF-α and sICAM-1 were compared between the two groups.Results In group P,Pmean,Ppeak,plasma IL-6,TNF-α and sICAM-1 concentrations at T1-T4were significantly lower than those in group V(P＜0.05).In group P,the Cd values at T2,T3,T4were higher than those in group V (P＜0.05).Conclusion The PCV-VG mode can decrease the Ppeak and Pmean in patients undergoing retroperitoneal laparoscopic surgery,increase Cd values,and reduce plasma concentrations of IL-6,TNF-α and sICAM-1,and control the occurrence of lung injury to some extent. 2018 Vol. 25 (23): 60-63 [Abstract] ( 160 ) HTML (51 KB)  PDF  (0 KB)  ( 129 ) 64 Clinical effect of laparoscopic treatment for acute appendicitis in children ZHENG Wen-long;CAI Hong-bin;LAI Zhi-hong Objective To investigate the clinical effect of laparoscopic treatment of acute appendicitis in children.Methods A total of 78 children with acute appendicitis admitted to our hospital from September 12 to December 15,2017 were selected as the research objects,and divided into control group and observation group with 39 cases in each group by random number table method.The observation group was given laparoscopic surgery while the control group was given routine laparotomy.The clinical indexes(hospitalization time,intraoperative blood loss,anal exhaust time,ambulation time)and complication rate (incision infection,abdominal abscess,adhesive intestinal obstruction)of the two groups were observed and compared.Results The hospitalization time,anal exhaust time and ambulation time of children in the observation group were shorter than those in the control group,and the amount of bleeding during operation was less than that in the control group,the difference was statistically significant(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05）.Conclusion Laparoscopic surgery for acute appendicitis in children has a high clinical value.it can speed up the recovery of the body after surgery on the basis of reducing the incidence of complications and is worthy of application and promotion. 2018 Vol. 25 (23): 64-66 [Abstract] ( 139 ) HTML (30 KB)  PDF  (0 KB)  ( 31 ) 67 Effect of automatic ligation of hemorrhoids combined with scissors ligation in the treatment of mixed hemorrhoids WAN Yue-ming;CHEN Ying-ju;LI Xiao-yan;MO Peng-shi;LIANG Yong-hui Objective To investigate the efficacy of automatic ligation of hemorrhoids (RPH)combined with incision ligation in the treatment of mixed hemorrhoids.Methods A total of 200 mixed hemorrhoids patients admitted to our hospital from January 2015 to March 2017 were selected and divided into control group and combined operation group by random number table method,with 100 cases in each group.The control group was treated with scissors ligation,while the combined operation group was treated with RPH combined with scissors ligation.The curative effect of the two groups of mixed hemorrhoids was compared.Postoperative discharge time and average wound healing time.Before and after the operation,the patient′s anal canal rest pressure,diastolic pressure,maximum systolic pressure,and the total incidence of complications.Results The total effective rate of the combined operation group was higher than that of the control group,the differences were statistically significant(P＜0.05).Before surgery,there was no statistical difference between the two groups(P＞0.05),in the static pressure,diastolic pressure and maximum systolic pressure of anal canal.After the operation,the anal canal rest pressure,diastolic pressure and maximum systolic pressure in the combined operation group were lower than those in the control group,the differences were statistically significant(P＜0.05).The postoperative discharge time and average wound healing time in the combined operation group were shorter than those in the control group the differences were statistically significant(P＜0.05).The total incidence of complications in the combined operation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion RPH combined with incision ligation is effective in treating mixed hemorrhoids.It can effectively accelerate wound healing,reduce complications,improve anal diastolic pressure and systolic pressure.It is beneficial to shorten hospitalization time and better improve the quality of life of patients.It is worth promoting. 2018 Vol. 25 (23): 67-69 [Abstract] ( 144 ) HTML (33 KB)  PDF  (0 KB)  ( 30 ) 70 Application value of ankle joint orthotic support in treatment of patients with foot drop and cubitus varus hemiplegia caused by brain injury DENG Hai-yan Objective To investigate the curative effect of ankle orthopedic brace on foot drop and hemiplegic foot varus caused by brain injury.Methods From January 20,2014 to January 20,2017,80 patients with foot drop and cubitus varus hemiplegia caused by brain injury admitted to our hospital were selected as research objects.They were divided into routine group and experimental group,by random number table method,with 40 cases in each group.The experimental group was treated with routine rehabilitation therapy plus ankle orthopedic support,while the routine group was treated with routine rehabilitation therapy.All patients were followed up for 1 year.the motor function score,daily life activity score,walking speed,6 min walking distance and satisfaction were compared between the two groups.Results After the intervention,the scores of motor function and activity of daily life in the two groups were higher than those before the intervention,and the scores of motor function and activity of daily life in the experimental group were higher than those in the conventional group,the differences were statistically significant(P＜0.05).Before the intervention,there was no significant difference in the walking speed and 6 min walking distance between the two groups(P＞0.05).After the intervention,the walking speed and 6 min walking distance of the two groups were significantly higher than those before the intervention,and the walking speed and 6 min walking distance of the experimental group were higher than those of the conventional group,the differences were statistically significant(P＜0.05).The patients′total satisfaction in the experimental group was higher than that in the conventional group,and the difference was statistically significant(P＜0.05).Conclusion It is feasible to take ankle joint orthotic support intervention for patients with foot drop and cubitus varus hemiplegia caused by brain injury.it can significantly improve the patients'motor function and their ability of daily living activities,and the effect is better. 2018 Vol. 25 (23): 70-72 [Abstract] ( 113 ) HTML (34 KB)  PDF  (0 KB)  ( 28 ) 73 Effects of omeprazole-based triple therapy on serum inflammatory factors and gastrointestinal hormones in patients with Helicobacter pylori-infected gastric ulcer ZHAO Jing;YI Jing Objective To investigate the effect of omeprazole-based triple therapy on serum inflammatory factors and gastrointestinal hormones in patients with Helicobacter pylori-infected gastric ulcer.Methods A total of 84 patients with Helicobacter pylori-infected gastric ulcer admitted to our hospital from November 2015 to October 2017 were selected and divided into reference group and experimental group by random number table method,with 42 cases in each group.The reference group was treated with omeprazole and amoxicillin,while the experimental group was treated with omeprazole-based triple therapy.The therapeutic effects of the two groups of patients,as well as the changes of serum inflammatory factors and gastrointestinal hormone levels were studied and compared.Results The total effective rate in the experimental group was significantly higher than that in the reference group,the differences were statistically significant(P＜0.05).Before treatment,there was no significant difference between the two groups(P＞0.05).After treatment,the levels of serum inflammatory factors in the two groups were lower than those before treatment,and the levels of serum inflammatory factors in the experimental group were significantly lower than those in the reference group,the differences were statistically significant(P＜0.05).Before treatment,there was no statistically significant difference in gastrointestinal hormone levels between the two groups before and after treatment(P＞0.05).After treatment,the gastrointestinal hormone levels in the two groups were lower than those before treatment,and the gastrointestinal hormone levels in the experimental group were significantly lower than those in the reference group,the differences were statistically significant(P＜0.05).Conclusion Omeprazole-based triple therapy can effectively improve the levels of serum inflammatory factors and gastrointestinal hormone in the treatment of patients with Helicobacter pylori-infected gastric ulcer,which is beneficial to the recovery of the ulcer. 2018 Vol. 25 (23): 73-75 [Abstract] ( 135 ) HTML (34 KB)  PDF  (0 KB)  ( 30 ) 76 Clinical effect of quadruple therapy in treatment of Clarithromycin resistant Helicobacter pylori infection CHEN Shao-wen;ZHANG Zhen-feng;JI Ming-zhu ObjectiveTo analyze the clinical effect of quadruple therapy in treatment of Clarithromycin resistant Helicobacter pylori infection.Methods Sixty patients with Helicobacter pylori infection admitted to Nan′ao People′s Hospital in Dapeng New District,Shenzhen City from February 2014 to February 2017 were selected and divided into control group and study group,by random number table method with 30 cases in each group.The control group was treated with Metronidazole,Omeprazole and Amoxicillin triple therapy,while the study group was treated with Omeprazole,Bismuth Potassium Citrate Granules,Amoxicillin and Levofloxacin triple therapy.The eradication rate of Helicobacter pylori and the total incidence of adverse reactions were compared between the two groups.Results The eradication rate of Helicobacter pylori in the study group was 93.33%（28/30）,higher than 80%（24/30） in the control group,the difference was statistically significant(χ2=7.6876,P=0.0056).There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion In the clinical treatment of Helicobacter pylori infection,Omeprazole,Amoxicillin,Bismuth Potassium Citrate Granules and Levofloxacin are recommended to be the first choice for quadruple therapy,which can improve the eradication rate of helicobacter pylori and is worth further promotion. 2018 Vol. 25 (23): 76-78 [Abstract] ( 170 ) HTML (37 KB)  PDF  (0 KB)  ( 36 ) 79 Application effect of optimized dressing change process based on moist healing theory in chronic wounds of lower limbs HU Jin-ling;WANG Xiao-fen Objective To explore the application effect of optimal dressing change process based on moist healing theory in chronic wounds of lower limbs.Methods A total of 180 patients admitted to our hospital from January 2016 to December 2017 for the nursing of chronic wound dressing change of lower limbs were selected as the research object.90 patients from January to December 2017 were selected as the observation group,treated with optimized dressing change process based on wet healing theory,and 90 patients from January to December 2016 were selected as the control group,treated with conventional dressing change process.The frequency of dressing change,pain score,total cost of dressing change and total effective rate of treatment were compared between the two groups.Results The frequency of dressing change in the observation group was less than that in the control group,the pain score was lower than that in the control group,and the total cost of dressing change was less than that in the control group,the difference was statistically significant(P＜0.05).The total effective rate of wound treatment in the observation group was higher than that in the control group,the difference was statistically significant(P＜0.05).Conclusion The optimized dressing change process based on moist healing theory can effectively reduce the number of dressing changes and improve the wound treatment effect,thus reducing the pain discomfort and economic burden of patients. 2018 Vol. 25 (23): 79-81 [Abstract] ( 137 ) HTML (36 KB)  PDF  (0 KB)  ( 30 ) 82 Effect of integrated traditional Chinese and western medicine therapy on diabetic nephropathy complicated with osteoporosis YU Jing;SUN Yue-xian;BAI Li-ping;LIU Xiao-qin Objective To explore the effect of integrated traditional Chinese and western medicine in treating diabetic nephropathy with osteoporosis.Methods A total of 76 patients with diabetic nephropathy and osteoporosis admitted to Hongqi hospital affiliated to Mudanjiang medical college from January 2016 to July 2017 were selected as the research objects.Random number table was used and divided into control group and traditional Chinese medicine group with 38 cases in each group.The control group was treated with conventional western medicine while the traditional Chinese medicine group was treated with traditional Chinese medicine prepared by our hospital.Six months later,the treatment effect was evaluated from the following three aspects：bone mineral density measurement,traditional Chinese medicine symptom score and treatment effect.Results Before treatment,there was no statistically significant difference in bone mineral density between the right femoral neck and lumbar spine (L1-4)between the two groups (P＞0.05).After treatment,the bone density of the right femoral neck and lumbar vertebrae (L1-4)in the two groups was higher than that before treatment,and the bone density of the right femoral neck and lumbar vertebrae (L1-4)in the Chinese medicine group was higher than that in the control group,the difference was statistically significant(P＜0.05).Before treatment,the TCM symptom score of the control group was(37.23±2.12)points and the TCM group was(37.38±1.96)points.There was no statistical difference between the two groups (t=1.536,P=0.758).After treatment,the TCM symptom score of the control group was （23.85±3.77） points,which was higher than that of the TCM group （19.02±2.96） points,and the difference was statistically significant （t=5.872,P=0.000）.The total effective rate of the patients in the TCM group was higher than that in the control group,the difference was statistically significant (P＜0.05).Conclusion Combination of traditional Chinese and western medicine can effectively improve rehabilitation effect of diabetic nephropathy patients with osteoporosis. 2018 Vol. 25 (23): 82-84 [Abstract] ( 146 ) HTML (36 KB)  PDF  (0 KB)  ( 17 ) 85 Effect of Tiotropium Bromide combined with Montelukast on pulmonary function,inflammatory cells in sputum and expression of inflammatory factors in patients with chronic obstructive pulmonary disease HUANG Sui-hua;DONG Jing-jun;DENG Jie-fang Objective To investigate the effect of Tiotropium Bromide combined with Montelukast on lung function,inflammatory cells in sputum and expression of inflammatory factors in patients with chronic obstructive pulmonary disease (COPD).Methods A total of 86 COPD patients admitted to our hospital from April 2017 to March 2018 were selected and divided into control group and observation group with 43 cases in each group by random number table method.The control group was treated with Theophylline Sustained-release Tablets orally,while the study group was treated with Tiotropium Bromide combined with Montelukast.The levels of forced expiratory volume (FEV1),vital capacity (FVC),ratio of forced expiratory volume to vital capacity (FEV1/FVC),sputum myeloperoxidase (MPO),interleukin (IL)-8,leukotriene B4 (LTB4),neutrophils and eosinophils were compared before and after the intervention.Results Before the intervention,there was no statistical difference between the two groups(P＞0.05).After the intervention,the lung function related indexes of the two groups were higher than those before the intervention,and the differences were statistically significant(P＜0.05).The lung function related indexes of the patients in the study group were higher than those of the control group,and the differences were statistically significant(P＜0.05).Before the intervention,there was no statistically significant difference in sputum inflammatory factors between the two groups (P＞0.05).After the intervention,the sputum inflammatory factors of the two groups of patients were lower than those before the intervention,the differences were statistically significant(P＜0.05),and the sputum inflammatory factors of the patients in the study group were lower than those of the control group,the differences were statistically significant(P＜0.05).Before the intervention,there was no statistically significant difference between the two groups in inducing sputum inflammatory cells(P＞0.05).After the intervention,the induced sputum inflammatory cells in the two groups were lower than those before the intervention,and the difference was statistically significant(P＜0.05).The induced sputum inflammatory cells in the study group were lower than those in the control group,the differences were statistically significant(P＜0.05).Conclusion Tiotropium Bromide combined with Montelukast can significantly improve the pulmonary function of COPD patients,reduce the level of inflammatory factors in sputum and reduce inflammatory cells in sputum. 2018 Vol. 25 (23): 85-87转94 [Abstract] ( 143 ) HTML (38 KB)  PDF  (0 KB)  ( 29 ) 88 Effect analysis of transurethral ureteroscopic lithotripsy and minimally invasive percutaneous nephrolithotomy in the treatment of upper ureteral incarcerated stones LI Wen-huan;XU Wei-jie Objective To explore the effect of transurethral ureteroscopic lithotripsy(URL)and minimally invasive percutaneous nephrolithotomy (MPCNL)in the treatment of upper ureteral incarcerated stones.Methods From January 2016 to June 2017,72 patients with upper urethral incarcerated calculi were selected as the subjects,and divided into observation group and control group by random number table method,36 cases in each group.The control group was treated with URL and the observation group was treated with MPCNL.The operation time and intraoperative blood loss were observed and compared between the two groups.The stone clearance rate and postoperative complications were observed 3 and 30 days after operation to explore the therapeutic effect of the two methods.Results The time of operation and the amount of intraoperative bleeding in the observation group were not significantly different from those in the control group(P＞0.05).The stone removal rate in the observation group was significantly higher than that in the control group on the 3 d and 30 d after operation,and the difference was statistically significant(P＜0.05).There was no significant difference in the total incidence of postoperative complications between the two groups(P＞0.05).Conclusion The application of MPCNL in the treatment of upper ureteral incarcerated calculi can obviously improve the removal rate of stones and is an effective treatment method. 2018 Vol. 25 (23): 88-90 [Abstract] ( 153 ) HTML (34 KB)  PDF  (0 KB)  ( 27 ) 91 Effect of percutaneous nephrolithotomy combined with ureteroscope in the treatment of complicated renal ureteral calculi with supine anterolateral lithotomy position HE Wen-li;WEN Hai-dong Objective To analyze the effect of percutaneous nephrolithotomy combined with ureteroscope in the treatment of complicated renal ureteral calculi with supine anterolateral lithotomy position.Methods A total of 100 patients with complicated renal ureteral calculi undergoing urological surgery in our hospital from October 2016 to October 2017 were selected as the research subjects.The patients were divided into two groups by random number table method.In prone position group (n=50),patients were performed with percutaneous nephrolithotomy in prone position,while in supine anterolateral lithotomy position group(n=50),patients were performed with percutaneous nephrolithotomy combined with ureteroscope.The stone extraction rate once,total stone removal rate,operation time,blood transfusion rate,channel loss rate during dilation of percutaneous nephroscope,and hospital stay in the two groups were compared.The incidence of complications and patient′s satisfaction in the two groups were also observed.Results The success rate of stone extraction once and the total stone clearance rate in the supine anterolateral lithotomy position group was much higher than that in the prone position group,the differences were statistically significant(P＜0.05).The operation time and hospital stay in the supine anterolateral lithotomy position group were both shorter than those in the prone position group,the difference was statistically significant(P＜0.05).The channel loss rate during dilation of percutaneous nephroscope in the supine anterolateral lithotomy position group was lower than that in the prone position group,the difference was statistically significant(P＜0.05).The patients′satisfaction in the supine anterolateral lithotomy position group was higher than that in the prone position group,the difference was statistically significant(P＜0.05).Conclusion For patients with complicated renal ureteral calculi,percutaneous nephrolithotomy combined with ureteroscope in the supine anterolateral lithotomy position obtains a great effect with high stone clearance rate and patient′s satisfaction,which is worthy of recommendation in clinical practice. 2018 Vol. 25 (23): 91-94 [Abstract] ( 113 ) HTML (37 KB)  PDF  (0 KB)  ( 38 ) 95 The curative effect comparison in initial total hip arthroplasty by direct anterior approach and posterolateral approach CHEN Jun-yan;WU Zhi-bin;CHEN Guo-jian Objective To compare the effect comparison in initial total hip arthroplasty by direct anterior approach and posterolateral approach.Methods The clinical data of 80 cases with initial total hip arthroplasty treated in our hospital from February 2016 to February 2018 were analyzed,which was to be divided into two groups by different treatment methods,direct anterior approach group 40 cases and posterolateral approach group 40 cases.The average femoral head prosthesis diameter,acetabulum abducent angles,hip joint function,complication of two groups initial total hip arthroplasty patients were detected.Results The average femoral head prosthesis diameter,acetabulum,acetabulum abducent angles between two groups were campared,the difference were no statistical significance (P＞0.05),the comparison of hip joint function total effective rate,the difference were no statistical significance(P＞0.05),the total incidence rate of complication in posterolateral approach group was higher than direct anterior approach group,the difference were statistical significance (P＜0.05）.Conclusion The curative effect comparison in initial total hip arthroplasty by direct anterior approach and posterolateral approach is good,but dearticulation rate after operation by direct anterior approach is low,it is worth to be used. 2018 Vol. 25 (23): 95-97 [Abstract] ( 127 ) HTML (35 KB)  PDF  (0 KB)  ( 30 ) 98 Analysis of treatment results of internal fixation with crossed K-wire on olecranon fracture in children WU De-chao;HAN Jing-ming;YOU Chao;XIA Yong-jie;WANG Jian-sheng Objective To compare the clinical efficacies of crossed K-wire fixation and K-wire combined with tension band internal fixation in the treatment of children′s olecranon and to discuss the surgical indications.Methods A total of 48 children with olecranon fractures treated in our department from January 2014 to December 2015 were selected and divided into the group of K-wire fixation （K-W group） （22 cases） and the group of tension band wiring （TBW group） （26 cases） according to the surgery procedure.The K-W group was treated with open reduction and crossed K-wires fixation and the TBW group was treated with open reduction and tension band wiring fixation.The incision length,the duration of the surgery,the intraoperative blood loss,the duration of immobilization,postoperative complications,and elbow function evaluation were compared between the two groups.Results The incision length in the of K-W group was shorter than that in the TBW group,duration of surgery and cast immobilization,intraoperative blood loss in the K-W group were losser than that in the TBW group,postoperative complications in the K-W group was lower than that in the TBW group,duration of the surgery and the duration of immobilization was shorter than that in the TBW group,which had significant differences(P＜0.05）.There was no significant difference in elbow function evaluation between the two groups(P＞0.05）.Conclusion The use of crossed K-wire without tension band in the treatment of olecranon fractures in children is safe and effective,and has advantages in reducing surgical injuries. 2018 Vol. 25 (23): 98-101 [Abstract] ( 130 ) HTML (43 KB)  PDF  (0 KB)  ( 27 ) 102 Application of locking plate and bone graft fixation combined with early functional exercise in the treatment of patients with tibial plateau fractures LIU Xiong-ye;WANG Rong-sheng;SHI Yu-ming Objective To investigate the clinical effect of locking plate and bone graft fixation combined with early functional exercise in the treatment of patients with tibial plateau fractures.Methods A total of 98 patients with tibial plateau fractures treated in our hospital from January 2014 to March 2017 were selected as study subjects.They were all provided with locking plate and bone graft fixation combined with early functional exercise in order to observe postoperative complications,complete loading time,healing time of bone fracture,knee joint scoring standard(HSS)scores.Meanwhile,the degrees of PA and TPA at different time after surgery were compared.ResultsAmong 98 patients,there was no severe skin necrosis,loosening of steel plates or wound infection.After one year of follow-up， the patient′s complete loading time was 90-110 d,average (98.69±3.69） d.The fracture healing time was 87-112 d,average(96.98±3.32） d.The HSS scores after 3,6 and 12 months operation were (72.12±10.16） points,(77.45±9.81） points,and(84.65±11.20)points in turn.The excellent and good rate was 95.92%after 12 months operation,significantly higher than 76.53%and 83.67%after 3 and 6 months operation respectively,with statistical significance (P＜0.05）.Conclusion Locking plate and bone graft fixation combined with early functional exercise have significant effect in the treatment of patients with tibial plateau fractures,which can effectively promote fracture and joint function recovery without complications,and paly positive significance for the improvement of postoperative quality of life. 2018 Vol. 25 (23): 102-105 [Abstract] ( 104 ) HTML (38 KB)  PDF  (0 KB)  ( 27 ) 106 The short-term effects of laparoscopic radical resection of colorectal cancer in the treatment of colorectal cancer ZOU Wei-qiang;LI Fa-hui;LI Jin-yuan Objective To explore the short-term effect of laparoscopic radical resection of colorectal cancer in the treatment of colorectal cancer.Methods A total of 76 cases of colorectal cancer treated in our hospital from March 2015 to April 2017 were selected as the subjects,and they were divided into two groups according to random number table method,38 cases in each group.The control group was treated with radical resection of colorectal cancer,and the observation group was treated with laparoscopic radical resection of colorectal cancer,and the curative effect of the two groups was compared.Results There was no significant difference in the time of operation and the number of lymph node dissection between the two groups (P＞0.05).The incision length,length of hospital stay and exhaust time of the observation group were significantly shorter than those of the control group,the differences were statistically significiant(P＜0.05).The amount of blood loss in the observation group was significantly lower than that in the control group,and the difference between the two groups was statistically significant(P＜0.05).The total incidence of complications in the observation group (13.1%)was significantly lower than that in the control group (36.9%),and the difference between the two groups was statistically significant(P＜0.05).The tumor metastasis rate and recurrence rate in the observation group were significantly lower than that in the control group after the surgery,and the survival rate was significantly higher than that in the control group,the differences between the two groups were significant(P＜0.05).ConclusionThe effect of laparoscopic radical resection of colorectal cancer for colorectal cancer patients is more significant than that of laparotomy,it can effectively reduce surgical trauma,speed up recovery,reduce complications,reduce metastasis and recurrence,and improve short-term survival rate,which is worthy of popularization and application. 2018 Vol. 25 (23): 106-108 [Abstract] ( 131 ) HTML (34 KB)  PDF  (0 KB)  ( 24 ) 109 Application value of tumor radiosensitizer in radiotherapy of nasopharyngeal carcinoma TANG Hua-yan;WU Chen;LI Rou Objective To investigate the application value of tumor radiosensitizer in radiotherapy of nasopharyngeal carcinoma.MethodsA total of 90 patients with nasopharyngeal carcinoma treated in our hospital from June 2015 to June 2017 were selected as the subjects,and divided into two groups by random number table method.The control group was given conventional radiation therapy,and the observation group was given radiotherapy with radiosensitizer.The therapeutic efficacy of nasopharyngeal carcinoma,the average survival time,the Kart score,the quality of life score before and after the intervention and the incidence of toxic side effects of radiation therapy were compared between the two groups.Results The effective rate of nasopharyngeal carcinoma in the observation group was higher than that in the control group,the difference was statistically significant(P＜0.05).The average survival time in the observation group was longer than that in the control group,the difference was statistically significant(P＜0.05).The difference was not statistically significant in Kappa score and quality of life score between the two groups (P＞0.05).After intervention,the Kart score and quality of life score in the observation group were higher than those in the control group,the difference was statistically significant(P＜0.05).The total incidence of toxic side effects of radiotherapy in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion The application of radiosensitizers for radiotherapy in the treatment of nasopharyngeal carcinoma is effective.It can effectively improve the therapeutic effect,reduce toxic and side effects,prolong survival time,and improve the quality of life of patients.It is worthy of popularization and application. 2018 Vol. 25 (23): 109-111 [Abstract] ( 136 ) HTML (35 KB)  PDF  (0 KB)  ( 29 ) 112 Clinical effect of endoscopic photodynamic minimally invasive technique in the treatment of cholangiocarcinoma DENG Ping Objective To investigate the clinical efficacy of endoscopic photodynamic minimally invasive techniques in the treatment of cholangiocarcinoma.Methods A total of 120 patients with gallbladder cancer who were admitted to our hospital from January 2015 to June 2017 were selected as the study subjects.The patients were randomly divided into study group(60 cases)and control group(60 cases)according to the random number table method.The patients in the control group were given endoscopic stenting.The patients in the study group were given photodynamic therapy on this basis.The quality of life(QOL)scores were compared between the two groups at different times.Results In the scale of quality of life,the physical conditions,social/family conditions,emotional conditions,hepatobiliary tumor-specific symptoms and total QOL scores at 3,6,9 and 12 months postoperatively in the study group were all significantly higher than those before the surgery,and the differences were statistically significant(P＜0.05).In the control group,only the physical conditions,social/family conditions,emotional conditions,hepatobiliary tumor-specific symptoms,and total QOL scores at 3 and 6 months after surgery were significantly higher than those before surgery,and the differences were statistically significant(P＜0.05).The total QOL scores before surgery were compared between the two groups,and the difference was not statistically significant(P＞0.05).The differences of the total QOL scores in the two groups at 6,9 and 12 months after surgery were statistically significant(P＜0.05).The total effective rate in the study group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).The overall incidence rate in the study group was significantly lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Endoscopic photodynamic minimally invasive therapy can significantly improve the quality of life of patients.The therapeutic effect is significant,and the incidence rate of adverse reactions is low,which is worthy of widespread clinical promotion and application. 2018 Vol. 25 (23): 112-114转117 [Abstract] ( 111 ) HTML (35 KB)  PDF  (0 KB)  ( 20 ) 115 Study with serum 25 dihydroxy vitamin D3，IL-10 and IgE levels in infants and young children with recurrent wheezing episodes 3，IL-10 and IgE levels in infants and young children with recurrent wheezing episodes[J]. 中国当代医药, 2018,25(23): 115-117')" href="#"> PAN Xue-jun;WU Shao-wei;YE Shao-bin;YUAN Wen-hua;PAN Yu-yun Objective To explore the correlation between recurrent wheezing attacks and serum 25 hydroxyvitamin D3,IL-10 and IgE levels in infants.Methods Fifty cases of recurrent wheezing infants and young children treated in our hospital from January to December 2017 were selected as the observation group,and 50 healthy children were selected as the control group for the same period.The serum levels of 25 hydroxyvitamin D3,IL-10 and IgE were detected in the two groups,and the results of the test were compared.Results IgE(161.32±24.26)IU/ml in the observation group was higher than that of the control group.IL-10(25.03±6.49)pg/ml and serum 25 hydroxyvitamin D3(47.36±15.42)nmol/L were lower than those in the control group,the differences were statistically significant(P＜0.05）.Conclusion Recurrent wheezing in infants is associated with the levels of IL-10,IgE and serum 25 hydroxyvitamin D3.The prevalence of vitamin D deficiency in children with recurrent wheezing in the region is common.Vitamin D supplementation can be used as a supplementary treatment for children with recurrent wheezing and may reduce the risk of eventual development of asthma. 2018 Vol. 25 (23): 115-117 [Abstract] ( 127 ) HTML (35 KB)  PDF  (0 KB)  ( 142 ) 118 Effect analysis of different ways of administration of Misoprostol on termination of gestation for 13 to 20 weeks HOU Feng;ZHOU Ping;XING Jia-ling Objective To determine effect of different ways of administration of Misoprostol on the termination of the mid-trimester pregnancy (13-20 weeks).Methods A total of 252 cases of receiving termination of the mid-trimester pregnancy in our hospital from June 2014 to June 2015 were selected.They were randomly divided into oral administration group(OA group),sublingual administration group(SA group),and vaginal administration group(VA group),84 cases in each group.Three groups were given Mifepristone 75 mg every time in the morning and night in the first day and the second day,Misoprostol 600 μg in the third day morning respectively.The abortion effects,adverse reactions and acceptability between the three groups were analyzed.Results There was no statistical difference in the beginning time of the abdominal pain and number hemorrhage among three groups(P＞0.05).The complete abortion rate and success rates of abortion in 24 h of the VA group and SA group were statistically significant higher than OA group.The abortion time of OA group were significantly longer than that in the VA group and SA group.No statistically significant differences in the incidence of the side-effect including fever,headache and so on (P＞0.05).Oral administration and sublingual administration were more acceptable than that in the VA group,the difference was statistically significant(P＜0.05).Conclusion The vaginal administration and sublingual administration of Misoprostol on the termination of the mid-trimester pregnancy have many advantages：high complete abortion rate,short abortion time,high success rates of abortion in 24 h,fewer side-effects.And sublingual administration were more acceptable by patients. 2018 Vol. 25 (23): 118-120 [Abstract] ( 118 ) HTML (35 KB)  PDF  (0 KB)  ( 30 ) 121 Analysis of risk factors of preterm premature rupture of membranes LIN Fang Objective To analyze the risk factors of preterm premature rupture of membranes(PPROM).Methods A total of 105 PPROM patients who were examined in our hospital from July 2015 to February 2017 were selected as the study group.Meanwhile,100 healthy pregnant women without premature rupture of membranes during the same period were chosen as the control group.The general clinical data,interleukin-6(IL-6),IL-8,tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),mean platelet volume(MPV),and procalcitonin(PCT)were compared in the two groups.The Logistic regression analysis was used to determine the factors affecting PPROM and the strengthen of effect of each index was demonstrated using the forest map.Results Compared with the control group,the levels of IL-6,IL-8,TNF-α,CRP,MVP,and PCT were all significantly increased in the study group,with a statistical difference (P＜0.05）.Multivariate regression analysis showed that the levels of IL-6,IL-8,TNF-α,CRP,MVP and PCT in peripheral blood were significantly associated with the occurrence of PPROM,with a statistical difference (P＜0.05）.Conclusion The levels of IL-6,IL-8,TNF-α,CRP,MVP and PCT in peripheral blood can be used to predict the risk of PPROM,which has certain clinical diagnostic value. 2018 Vol. 25 (23): 121-123 [Abstract] ( 109 ) HTML (33 KB)  PDF  (0 KB)  ( 34 ) 124 Analysis application of antibiotics in children with respiratory tract infection in pediatrics HE Zhi-feng Objective To investigate and analyze the use of antibiotics in pediatric children with respiratory tract infection.Methods50 pediatric patients with respiratory tract infection from January 1,2016 to December 31,2017 were selected.The clinical data of these 50 children with respiratory tract infection were analyzed retrospectively,and the use of antibiotics,such as the route of antibiotic administration and whether the antibiotics were used in a single drug,were investigated and counted.According to the drug utilization index of children,the rational use of antibiotics in children with respiratory tract infection was evaluated,the irrational use of antibiotics was statistically analyzed,and the reasons for irrational use of antibiotics were analyzed.Results Of the 50 cases of respiratory tract infection,47 cases were treated with antibiotics,the rate of antibiotic use was 94.00%,among which,the main route of antibiotic administration was oral administration,intravenous drip,single drug use was more than combined use.The antibiotics were mainly Cephalosporins(Cefuroxime et al.),Macrolides(Erythromycin et al.),and Penicillin(Penicillin et al.).The main reasons for the irrational use of antibiotics were unreasonable timing of administration,unreasonable dosage,unreasonable course of treatment,no clear indication of drug use,unreasonable compatibility of drugs and unreasonable choice of solvent.Conclusion The utilization rate of antibiotics in pediatric children with respiratory tract infection is high.The main route of antibiotic administration is oral administration,intravenous drip,most of them are single drug,and most of them are distributed in Cephalosporins,Macrolides and Penicillin.In order to promote the rational use of antibiotics in pediatric patients with respiratory tract infection,we should carry out targeted pharmaceutical intervention in order to promote the rational use of antibiotics in pediatric patients with respiratory tract infection. 2018 Vol. 25 (23): 124-126 [Abstract] ( 118 ) HTML (32 KB)  PDF  (0 KB)  ( 28 ) 127 Comparison of clinical effects of analgesia delivery and conventional delivery WU Yan-miao;YANG Yun Objective To compare the clinical effect of analgesia delivery and conventional delivery.Methods 100 cases pregnant women were selected from the gynecology and obstetrics of our hospital from March 2016 to September 2017,and were randomly divided into two groups according to the medical record number,55 cases in the control group were treated with the natural delivery.And the epidural anesthesia was applied to the 45 cases in the observation group on the basis of the control group.After production,the labor duration,degree of pain and neonatal Apgar score were compared between two groups.Results The first stage of labor of parturient in the observation group was significantly shorter than that in the control group,the difference was statistically significant(P＜0.05）.However,the comparison of the second stage of labor between two groups had no significant difference (P＞0.05）.The degree of pain in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05）.However,the comparison of the neonatal Apgar score between the two groups had no significant difference(P＞0.05）.Conclusion Analgesia delivery could significantly shorten the first production time,reduce the degree of pain,and have no negative effect on neonatal health. 2018 Vol. 25 (23): 127-129 [Abstract] ( 124 ) HTML (35 KB)  PDF  (0 KB)  ( 25 ) 130 Effect of Inhaled Budesonide Suspension on acute attack of pediatric asthma and its influence on pulmonary function ZHENG Feng-mei Objective To analyze the efficacy of Inhaled Budesonide Suspension on acute attack of pediatric asthma and its influence on pulmonary function.Methods From May 2014 to May 2017,80 asthmatic children with acute attack treated in our hospital were selected as the research subjects.They were equally divided into control group and observation group by a random number table method.In the control group,routine treatments such as cough relieving and expectoration were used,while in the observation group,Inhaled Budesonide Suspension on the basis of the control group was added.The improvement of clinical indicators,hospital stay,and changes in pulmonary function were analyzed in both groups.Results The total effectiveness rate in the observation group was 92.50%,which was significantly higher than that in the control group accounting for 75.00% (P＜0.05).The disappearing time of symptoms such as cough,wheezing,wheezing rale in the lungs,and dyspnea in the observation group was lesser than that in the control group,which was displayed statistical significant(P＜0.05）.The hospital stay in the observation group was significantly shorter than that of the control group(P＜0.05）.Before treatment,there was no significant difference in the lung function indexes such as forced expiratory volume in 1 s(FEV1),forced vital capacity(FVC),and peak expiratory flow (PEF)between the two groups(P＞0.05）.After 7 day treatment,the lung function indexes mentioned above of the two groups were significantly higher than those before treatment(P＜0.05）.The values of these lung function indexes in the observation group was higher than those in the control group with statistical differences after comparison(P＜0.05）.Conclusion For asthmatic children on acute attack,Inhaled Budesonide Suspension is beneficial to relieving clinical symptoms and improving lung function,shortening hospital stay,and promoting pediatric rehabilitation in a definite effect,which is worthy of clinical application. 2018 Vol. 25 (23): 130-132 [Abstract] ( 128 ) HTML (35 KB)  PDF  (0 KB)  ( 31 ) 133 Effect of intravenous drip of Oxytocin combined with COOK double balloon on cervical ripening and induced labor CHEN Yu-ting;CHU Xiao-li;TAO Chun-mei;CHEN Yun-xia Objective To observe the clinical effect of intravenous Oxytocin （OT） on cervical ripening induced labor combined with COOK double balloon.Methods All of 124 pregnant and parturient women who were treated in Shenzhen Shajing People′s Hospital of Bao′an District in Shenzhen City from July 2016 to December 2017 were selected as the object of observation.They were divided into observation group and control group according to random number table method,62 cases in each group..The control group was used controlledreleased dinoprostone suppositories for induction of labor,the observation group was used intravenous drip of OT to promote cervical maturation induced labor and combined COOK double balloon technique.The cervical ripening and the outcome of the two groups were compared.Results The total effective rate of cervical maturity in the observation group was 96.16%,which was significantly higher than that of the control group (80.65%).The rate of induced labor in the observation group was 90.32%,which was significantly higher than that of the control group(75.81%).In the way of delivery,the rate of vaginal delivery in the observation group was 69.35%,which was significantly higher than that of the control group (48.39%).The total labor process of vaginal delivery in the observation group was(406±163)min,which was significantly shorter than that of the control group ([543±194]min).The differences were statistically significant(P＜0.05）.Conclusions Intravenous drip of OT to promote cervical maturation induced labor combined with COOK double balloon is effective,which can promote cervical maturity and improve the rate of vaginal delivery. 2018 Vol. 25 (23): 133-135 [Abstract] ( 116 ) HTML (35 KB)  PDF  (0 KB)  ( 26 ) 136 Correlation study of the onset of hypertensive disorder complicatine pregnancy and maternal diet during pregnancy XIE Xue-song Objective To study the correlation between hypentensive disorder complicatine pregnancy(HDCP)and maternal pregnancy diet.Methods A total of 92 patients with PIH treated in our hospital from January to December in 2017 were selected as HDCP group.In the same period,90 normal pregnant women(normal pregnant group)were selected for control and observation.The correlation of dietary factors and HDCP was analyzed.Results There were significant differences in the daily intake of meat and salt,diet control,and body weight between the two groups (P＜0.05）.The above-mentioned differences were brought into the Logistic regression equation and found that the amount of daily meat and salt(r=0.638),diet control and body overweight were all related factors causing HDCP patients.There was a positive correlation between the amount of meat and salt(r=0.638)and body weight(r=0.713)and HDCP during pregnancy,and a negative correlation between diet control(r=-0.611)and HDCP was detected.Conclusion The onset of HDCP is closely related to the dietary habits of the pregnant women during pregnancy.Excessive intake of meat and salt,and uncontrolled diet are the main risk factors for hypertension.In clinical practice,besides active treatment,intervention on the maternal dietary habits can play an adjuvant role. 2018 Vol. 25 (23): 136-138 [Abstract] ( 119 ) HTML (33 KB)  PDF  (0 KB)  ( 19 ) 139 The effect of different induced labor on midterm pregnancy LIANG Zheng-yi Objective To explore the effect of different induced labor on midterm pregnancy induced labor.Methods The clinical data of 100 cases of intermediate pregnancy induced labor from March 2013 to March 2018 were analyzed retrospectively,according to the different induction methods,they were divided into the observation group and the control group,50 cases in each group.The observation group was used Mifepristone combined with Misoprostol for induction of labor,the control group was took Rivanol for induction of labor,comparative analysis of the two groups of patients with the success rate of labor induction,induction of labor and postpartum hemorrhage,patient complications and satisfaction rate.Results The success rate of the patients in the observation group was up to 100.00%,significantly higher than that in the control group 92.00%,and the difference was statistically significant(P＜0.05）.In the observation group,the induced labor time was shorter than that in the control group,and the blood loss was lesser than that in the control group,the differences were statistically significant(P＜0.01）.The total incidence rate of complication was 2.00%in the observation group,compared with the control group of 14.00%,and the total satisfaction rate was 98.00%,which was higher than in the control group (82.00%),and the differences were statistically significant(P＜0.05）.Conclusion Period of pregnancy induced labor way more,Mifepristone combined Misoprostol mid pregnancy induced labor success rate is high,the induced labor of short time,less blood loss and complication rate low,high safety,and patient satisfaction is high,is worth popularization and application. 2018 Vol. 25 (23): 139-141 [Abstract] ( 120 ) HTML (33 KB)  PDF  (0 KB)  ( 29 ) 142 Influence of oral irrigator on dental plaque and inhibition effect of gingivitis for children in tooth replacement period JIANG Jing;LI Hong-wen;GENG Fa-yun;WANG Xiao-yan;GENG Xiao-rui Objective To observe the influence of oral irrigator on dental plaque and inhibition effect of gingivitis for children in tooth replacement period.Methods A total of 60 children with gingivitis in tooth replacement period treated in our hospital from January 2016 to January 2018 were selected as study objects.The children were divided into the control group(n=20),dental floss group(n=20)and oral irrigator group(n=20)according to the random number table method.The control group was given the method of brushing teeth by BASS,the dental floss group were given the children′s dental floss pick on the basis of the method of brushing teeth by BASS,and the oral irrigator group was given the oral irrigator on the basis of the dental floss group.The gingival index (GI)and Quigley-Hein plaque index(QPI)were compared before treatment and after 14,30,and 60 d treatment among the three groups.Results There was no significant difference in the GI value and QPI value before treatment between the three groups(P＞0.05).The GI value and QPI value of after 14,30,60 d treatment in the three groups were all obviously lower than those before treatment,and the differences were statistically significant(P＜0.05),and the GI value and QPI value of after 14,30,60 d treatment were lower than those of the control group and dental floss group,and the differences were statistically significant(P＜0.05).Conclusion The oral irrigator applied in children in tooth replacement period can effectively play the inhibitory action for dental plaque and gingivitis. 2018 Vol. 25 (23): 142-144 [Abstract] ( 113 ) HTML (35 KB)  PDF  (0 KB)  ( 31 ) 145 Clinical effect of modified irrigator in the treatment of patients with ceruminal embolism due to stenosis of external auditory canal CAO Run-qin LI Ying-fang Objective To observe the clinical effect of modified irrigator in the treatment of patients with ceruminal embolism due to stenosis of external auditory canal.Methods A total of 90 patients with ceruminal embolism due to stenosis of external auditory canal treated in our department from November 2016 to November 2017 were selected as study objects.The patients were divided into the control group (n=45)and observation group (n=45)according to the random number table method.Patients in the control group were treated with traditional washing ear bulb,while patients in the observation group were given modified irrigator.The therapeutic effect between the two groups was compared.Results The total effective rate of treatment effect in the observation group was 93.3%,which was significantly higher than that of the control group(77.8%),and the difference was statistically significant(P＜0.05).The excellent and good rate of ear comfort in the observation group was 95.6%,which was significantly higher than that in the control group(82.2%),and the difference was statistically significant(P＜0.05).The total incidence of adverse reactions in the observation group was 6.7%,which was significantly lower than that in the control group(17.7%),and the difference was statistically significant(P＜0.05).Conclusion Modified irrigator in the treatment of patients with ceruminal embolism due to stenosis of external auditory canal can significantly improve the treatment effect and ear comfort,reduce the incidence of adverse reactions,and it is worthy of clinical promotion and application. 2018 Vol. 25 (23): 145-147 [Abstract] ( 123 ) HTML (36 KB)  PDF  (0 KB)  ( 23 ) 148 Effect of Alteplase combined with Butylphthalide Injection in the treatment of acute cerebral infarction ZENG Hong-liang;ZENG Xiang-jun Objective To investigate the effect of Alteplase combined with Butylphthalide Injection in the treatment of acute cerebral infarction and its effect on hemorheology and neurological function.Methods Eighty patients with acute cerebral infarction admitted to our hospital from January 2016 to October 2017 were selected as objects and divided into the control group(40 cases)and the observation group(40 cases)according to the random number table method.The control group was treated with Alteplase Thrombolysis and the observation group was treated with Butylphthalide Injection on the basis of the control group.Hemorheological indicators,neurological factors of S-100 protein(S100B),myelin basic protein (MBP),and clinical efficacy before treatment and 7 d after treatment between two groups were compared.Results The plasma viscosity and platelet aggregation rate of two groups after treatment were lower than those before treatment,and the differences were statistically significant(P＜0.05).The plasma viscosity and platelet aggregation rate in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P＜0.05).The levels of S100B and MBP of two groups after treatment were lower than those before treatment,and the differences were statistically significant(P＜0.05).The levels of S100B and MBP in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P＜0.05).The total effective rate of the observation group was 92.50%,which was higher than that of the control group(75.00%),and the difference was statistically significant(P＜0.05).Conclusion Alteplase combined with Butylphthalide Injection has significant effect on acute cerebral infarction,which can improve hemorrheology and neurological function,and is worth of promotion. 2018 Vol. 25 (23): 148-150转154 [Abstract] ( 123 ) HTML (36 KB)  PDF  (0 KB)  ( 30 ) 151 Effect of Atorvastatin in the treatment of X syndrome combined with hyperlipidemia ZHANG Di;SONG Zhan-chun;ZHAO Yue-chao;TIAN Mi Objective To investigate the effect of Atorvastatin in the treatment of X syndrome combined with hyperlipidemia.Methods A total of 94 patients with X syndrome and hyperlipidemia treated in our hospital from October 2016 to October 2017 were selected as subjects and were randomly divided into the control group (47 cases)and the observation group(47 cases).The control group was given routine treatment and the observation group was treated with Atorvastatin on the basis of the routine treatment.Biochemical indicators,cardiac anxiety scale (CAQ)score and cardiac evaluation indexs before and after treatment were compared between two groups,clinical effect and safety were also compared between two groups.Results The C-reactive protein (CRP),total cholesterol,triglyceride and low-density lipoprotein cholesterol in two groups after treatment were lower than those before treatment,the paraoxonase-1 and high-density lipoprotein cholesterol were higher than those before treatment,and the differences were statistically significant(P＜0.05).The CRP,total cholesterol,triglyceride and low-density lipoprotein cholesterol in the observation group after treatment were lower than those in the control group,the paraoxonase-1 and high-density lipoprotein cholesterol were higher than those in the control group,and the differences were statistically significant(P＜0.05).The score of CAQ and frequency of chest pain in two groups after treatment were lower than those before treatment,the time of exercise plate test and the maximum time of S segment depression were longer than those before treatment,and the differences were statistically significant(P＜0.05).The score of CAQ and frequency of chest pain in the observation group after treatment were lower than those in the control group,the time of exercise plate test and the maximum time of S segment depression were longer than those in the control group,and the differences were statistically significant(P＜0.05).The total effective rate of the observation group was 97.9%,which was higher than that of the control group(83.0%),and the difference was statistically significant(P＜0.05).There was no statistically significant difference in the safety of medication between two groups (P＞0.05).Conclusion Atorvastatin can effectively improve serum lipid level and cardiac function in patients with X syndrome and hyperlipidemia,which has significant effect. 2018 Vol. 25 (23): 151-154 [Abstract] ( 125 ) HTML (37 KB)  PDF  (0 KB)  ( 26 ) 155 Clinical effect of Probiotics Freeze-Dried Powder combined with bismuth-containing quadruple therapy in the treatment of Helicobacter pylori infection AN Min;GAO Zhen-jun Objective To observe the eradication rate and safety of Probiotics Freeze-Dried Powder combined with bismuth-containing quadruple therapy in the treatment of Helicobacter pylori(Hp)infection.Methods A total of 98 Hppositive patients who were diagnosed and treated in the outpatient clinic of our hospital from November 2016 to May 2017 were selected as the study subjects.They were randomly divided into quadruple medication group (49 cases)and combined medication group (49 cases).The quadruple medication group was treated with Rabeprazole,Amoxicillin,Clarithromycin and Colloidal Bismuth Pectin,while the combined medication group was further given Probiotics Freeze-Dried Powder on the basis of the quadruple medication group.The Hp eradication rate and the incidence rate of adverse reactions after treatment were compared between the two groups.Results The Hp eradication rate in the combined medication group was higher than that in the quadruple medication group,and the difference was statistically significant(P＜0.05).The incidence rate of adverse reactions was lower than that in the quadruple medication group,and the difference was statistically significant(P＜0.05).Conclusion Probiotics Freeze-Dried Powder combined with bismuth-containing quadruple therapy has a high eradication rate of Hp and fewer adverse reactions,which is appropriate for clinical promotion. 2018 Vol. 25 (23): 155-157转161 [Abstract] ( 190 ) HTML (34 KB)  PDF  (0 KB)  ( 34 ) 158 Clinical effect analysis of Trimetazidine Dihydrochloride in the treatment of patients with type 2 diabetes mellitus complicated with chronic heart failure LIN Shao-hua;CHEN Mei-qing Objective To investigate the clinical effect of Trimetazidine Dihydrochloride in the treatment of patients with type 2 diabetes mellitus (DM)complicated with chronic heart failure.Methods The clinical data of 92 patients with type 2 DM and chronic heart failure treated in the outpatient of our hospital from February 2014 to February 2017 were analyzed.They were divided into control group(32 cases)and combined treatment group(60 cases)acccording to the random paper method.The control group was given conventional therapy and the combined treatment group was treated with Trimetazidine Dihydrochloride on the basis of the control group.The levels of left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c)before and after treatment,and clinical effect after treatment of two groups were compared.There were no significant differences in levels of LVEF,LVEDD,and LVESD between two groups before treatment(P＞0.05).The levels of LVEF in two groups after treatment were higher than that before treatment,the levels of LVEDD and LVESD were lower than those before treatment,and the differences were statistically significant(P＜0.05).The level of LVEF in the combined treatment group after treatment was higher than that in the control group,the levels of LVEDD and LVESD were lower than those in the control group,and the differences were statistically significant(P＜0.05).There were no significant differences in levels of FBG and HbA1c between two groups before treatment(P＞0.05).The levels of FBG and HbA1c in two groups after treatment were lower than those before treatment,and the difference was statistically significant(P＜0.05).The levels of FBG and HbA1c in the combined treatment group after treatment were lower than those in the control group,and the difference was statistically significant(P＜0.05).The total effective rate of treatment in the combined treatment group was higher than that in the control group,and the difference was statistically significant(P＜0.05).There were no adverse reactions related to the drug use in two groups during the treatment period.Conclusion Trimetazidine Dihydrochloride in the treatment of patients with type 2 DM complicated with chronic heart failure can significantly improve cardiac function and reduce levels of FBG and HbA1c with significant effect,which is worthy of clinical promotion and application. 2018 Vol. 25 (23): 158-161 [Abstract] ( 116 ) HTML (37 KB)  PDF  (0 KB)  ( 29 ) 162 Clinical effect of Acetylcysteine Granules in the treatment of whooping cough REN Xiao-mei Objective To investigate the clinical effect of Acetylcysteine Granules in the treatment of children with whooping cough.Methods A total of 120 children patients with whooping cough who were admitted to the department of infectious diseases in our hospital from January to December,2017 were selected as objects.According to the random pairing design,they were divided into the treatment group(60 cases)and the control group(60 cases).In the control group,Erythromycin or Azithromycin was used to prevent infection,Bromhexine Hydrochloride or Ambroxol for relieving cough and phlegm,Budesonide,Terbutaline oxygen inhalation and sucking care treatment.The treatment group received oral Acetylcysteine Granule on the basis of conventional treatment in the control group.The clinical symptoms,time of hospital stay,and total effective rates were compared between the two groups.Results The duration of spastic cough,the duration of cholestre-like echo,the duration of vomiting after cough,the duration of paroxysmal cyanosis,the disappearance of pulmonary rales,and the time of hospital stay in the treatment group after treatment were shorter than those in the control group,and the differences were statistically significant(P＜0.05).The total effective rate in the treatment group was higher than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion On the basis of conventional treatment,further oral administration of Acetylcysteine Granules in the treatment of whooping cough can significantly reduce the clinical symptoms and shorten the course of the disease in children.The drug is convenient for oral administration,safe,and easy to accept,which is worthy of clinical promotion. 2018 Vol. 25 (23): 162-165 [Abstract] ( 131 ) HTML (38 KB)  PDF  (0 KB)  ( 31 ) 166 Effect of Esomeprazole combined with Somatostatin in the treatment of severe acute pancreatitis YANG Ting;WU Jian-wei;TANG Hong-ling;CHENG Yan-lin Objective To explore the effect of Esomeprazole combined with Somatostatin(SS)in the treatment of severe acute pancreatitis (SAP)and its effect on intestinal mucosal barrier function and inflammatory transmitter levels.Methods A total of 84 cases of patients with SAP treated in our hospital from October 2015 to October 2017 were selected as objects and randomly divided into the control group and the observation group,with 42 cases in each group.The control group was given conventional symptomatic support,and the observation group was given Esomeprazole combined with SS on the basis of the control group.The symptom indicators,overall treatment effects,intestinal mucosal barrier function and inflammatory transmitter levels were compared between the two groups after treatment.Results After treatment,the relief time of abdominal pain and abdominal distension,the exhaust recovery time and the serum amylase recovery time in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P＜0.05).The rate of total clinical effective in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).The levels of D-lactic acid,DAO,endotoxin and L/M in the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P＜0.05).The levels of D-lactic acid,DAO,endotoxin and L/M in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P＜0.05).The levels of IL-6,IL-8,CRP,and TNF-α in the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P＜0.05).The levels of IL-6,IL-8,CRP,and TNF-α in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Esomeprazole combined with SS for SAP can improve the symptoms and the treatment effective rate,promote the recovery of intestinal mucosal barrier function and reduce the levels of inflammatory mediators,which is worthy of clinical application. 2018 Vol. 25 (23): 166-168 [Abstract] ( 126 ) HTML (37 KB)  PDF  (0 KB)  ( 26 ) 169 Clinical effect of Oseltamivir Phosphate in the treatment of children with influenza B LAN Xing-li Objective To investigate the clinical effect of Oseltamivir Phosphate in the treatment of children with influenza B.MethodsA total of 60 children with influenza B from October 2016 to October 2017 treated in the department of pediatrics of our hospital were selected as research objects and randomly divided into the control group and the observation group,with 30 cases in each group.The control group was treated with routine therapy,while the observation group was treated with Oseltamivir Phosphate on the basis of the control group.The clinical efficacy,time of symptom improvement,level changes of inflammatory factors and adverse reactions were compared between two groups.Results The total effective rate of the observation group was 93.33%,which was significantly higher than that of the control group (76.67%),and the difference was statistically significant(P＜0.05).The improvement time of dry cough,the remission time of sore throat,the normal time of body temperature recovery and the time of treatment in the observation group after treatment were significantly shorter than those in the control group,and the differences were statistically significant(P＜0.05).The levels of IFN-γ,IL-6 and TNF-α in two groups after treatment were significantly lower than those before treatment,and the differences were statistically significant(P＜0.05).The levels of IFN-γ,IL-6 and TNF-α in the observation group 5 d after treatment were significantly lower than those in the control group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of gastrointestinal adverse reactions such as abdominal pain,diarrhea,nausea and vomiting between two groups (P＞0.05).Conclusion The effect of Oseltamivir Phosphate in the treatment of infantile influenza B is significant,which is beneficial to the rapid improvement of symptoms,promoting the abatement of inflammation,shortening the time of treatment,and has high safety,with positive clinical significance. 2018 Vol. 25 (23): 169-171 [Abstract] ( 113 ) HTML (37 KB)  PDF  (0 KB)  ( 37 ) 172 Effect of Tenofovir combined with Lamivudine in the treatment of patients with Hepatitis B virus/Human immunodeficiency virus co-infection ZHANG Hua-min;FANG Gui-hua;DENG Qiao-juan Objective To investigate the clinical effect of Tenofovir combined with Lamivudine in the treatment of coinfection of Hepatitis B virus(HBV)and Human immunodeficiency virus(HIV).Methods Sixty patients with HIV/HBV admitted to our hospital from January 2014 to December 2016 were selected as subjects and divided into the control group(n=30)and the study group(n=30)according to the random number table method.The control group was treated with Lamivudine,while the study group was treated with Tenofovir on the basis of the control group.The HIV-RNA load,HBV-DNA load,CD4+T lymphocyte level,immunoglobulin level,liver function related indicators and adverse reactions were compared between the two groups after treatment.Results The rate of HIV-RNA below the lower limit and HBV-DNA below the lower limit in the study group were significantly higher than those in the control group,and the differences were statistically significant(P＜0.05).The CD4+T lymphocytes of the study group was (238.46±26.48)per 1 μl,which was significantly higher than that of the control group ([164.32±12.44]per 1 μl),and the difference was statistically significant(t=7.452,P＜0.05).The immunoglobulin level of the study group was significantly higher than that of the control group,and the difference was statistically significant(P＜0.05).The levels of alanine transaminase (ALT)and aspartate aminotransferase (AST)in the study group were significantly lower than those in the control group,and the differences were statistically significant(P＜0.05).There were no significant differences in levels of total bilirubin(TBIL)between two groups(P＞0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P＞0.05).ConclusionTenofovir combined with Lamivudine in the treatment of patients with HIV and HBV can significantly reduce the viral load in the body and improve the immune function and liver function,with safe and effective clinical application. 2018 Vol. 25 (23): 172-174 [Abstract] ( 130 ) HTML (36 KB)  PDF  (0 KB)  ( 20 ) 175 The influence of smoking,drinking and doing exercise on female sexual function of childbearing age CHEN Jing;LI Ping Objective To analyze the influence of smoking,drinking and doing exercise on female sexual function of childbearing age.Methods A total of 800 women with child-bearing age (25-35 years old)treated in Maternal and Child Health Hospital of Xiamen City from October 2014 to October 2015 were selected.Among them,eliminating those who had a history of mental illness,liver and kidney function damage,cardiovascular system diseases,hyperthyroidism or hypothyroidism and malignant tumors (15 cases)and having no sexual life in a month (21 cases),the remaining 764 cases were included in the statistics.Anonymous questionnaire method was used.Before the patient came to the hospital,the researcher explained and filled out the questionnaire.Patient filled out the questionnaire on the premise of voluntary,and kept it strictly confidential for patients.Filled time was about 10 minutes,the score was calculated by the researchers.Results Among the 764 patients enrolled,there were 116 cases in smoking group (＞3 day)and 308 cases were non-smoking group,there was no significant difference in age between the two groups ([30.00±5.10]years old vs.[29.16±6.98]years old)(P＞0.05).The orgasm,satisfaction score and total score of smoking group were lower than those of non-smoking group,and the differences were statistically significant(P＜0.05).There was no significant difference in the scores of other factors between the two groups (P＞0.05).There were 94 cases in drinking group (＞1 bottle/day)and 248 cases in non-drinking group (＜1 bottle/week),there was no significant difference in age between the two groups([31.00±2.10]years old vs.[20.46±5.88]years old)(P＞0.05).The orgasm score of drinking group was lower than that of non-drinking group,and the difference was statistically significant(P＜0.05).There was no significant difference in the scores of other factors between the two groups(P＞0.05).There were 307 cases in doing exercise group(＞1 time/week)and 457 patients were in non-doing exercise group,there was no significant difference in age between the two groups([30.82±6.40]years old vs.[31.27±7.93]years old)(P＞0.05).The sexual excitement,orgasm score and total score of doing exercise group were higher than those of non-doing exercise,and the differences were statistically significant(P＜0.05).Conclusion Smoking,drinking and not doing exercise regularly are risk factors for female sexual dysfunction.In the process of treatment and care for women seeking treatment,in order to improve the quality of life,their way of life and whether sexual function having an obstacle should be understood,and appropriate medical and psychological treatment are used to improve its sexual function. 2018 Vol. 25 (23): 175-178 [Abstract] ( 123 ) HTML (41 KB)  PDF  (0 KB)  ( 31 ) 179 Investigation and study of the quality of life and depression in patients with androgenic alopecia and alopecia areata LIN Han-biao Objective To study the influence factors of the quality of life and depression in patients with androgenic alopecia and alopecia areata and its relativity.Methods A total of 213 patients with androgenetic alopecia and alopecia areata treated in our hospital from September 2015 to October 2017 were selected as study objects.The quality of life and depression of patients were evaluated by the dermatology life quality index and Center For Epidemiologic Studies depression scale.Results A total of 213 questionnaires were collected and 213 valid questionnaires were actually recovered.The average score of quality of life index in patients with androgenetic alopecia was(8.77±5.23)scores and the average score of quality of life index in patients with alopecia areata was(9.38±5.49)scores.The average score of quality of life index in all patients was(9.12±5.41)scores.There was no significant difference in the average score of quality of life index in patients with different types hair loss(P＞0.05).The average score of depression scale in patients with androgenetic alopecia was(14.87±9.81)points.The depression scale of androgenetic alopecia patients were averaged(14.87±9.81)scores,and the average score of depression scale in patients with androgenetic alopecia were(14.50±10.31)scores.The average score of depression scale in all patients was(14.79±10.12)scores.There was no significant difference in the average score of depression scale in patients with different types hair loss(P＞0.05).There was no significant difference in the life quality index of patients with different sex,age group,education level and number of visits(P＞0.05).There was no significant difference in the score of depression scale of patients with different sex,age group and education level(P＞0.05),and there was significant difference in the depression scale of patients with different visits(P＜0.05).The quality of life index of the two types of hair loss patients was positively correlated with the depression scale score(r=0.24,P=0.008;r=0.26,P=0.006).Conclusion Androgenetic alopecia and alopecia areata will have moderate and severe influences on the quality of life of most patients,and may cause different degree of depression. 2018 Vol. 25 (23): 179-181转185 [Abstract] ( 123 ) HTML (34 KB)  PDF  (0 KB)  ( 34 ) 182 Investigation of reproductive health knowledge status in artificial abortion persons form foreign female workers of Baoan District in Shenzhen City CHEN Xia-ming;LIN Xian-xue Objective To investigate the reproductive health knowledge status in artificial abortion persons form foreign female workers of Baoan District in Shenzhen City,so as to provide guidance and assistance for reproductive health knowledge propaganda and education in the future.Methods A total of 1000 artificial abortion persons form foreign female workers of Baoan District in Shenzhen City from January 2017 to January 2018 were selected as study objects,a questionnaire survey method was used to investigate the reproductive health knowledge status.Results The awareness rate of pregnancy symptoms was 84.2%,the awareness rate of contraception method was 77.4%,the awareness rate of complications of artificial abortion was 65.6%,and the awareness rate of sexually transmitted diseases was 47.8%among the 1000 artificial abortion persons form foreign female workers.The awareness rate of pregnancy symptoms,contraceptive methods,complications of artificial abortion and sexual transmission diseases of the＞35 years old group were higher than those of the ＜35 years old group with statistically significant differences(P＜0.05).The awareness rate of pregnancy symptoms,contraceptive methods,complications of artificial abortion and sexual transmission diseases of the undergraduate and above group were higher than those of the high school and below with statistically significant difference(P＜0.05).The awareness rate of pregnancy symptoms,contraceptive methods,complications of artificial abortion and sexual transmission diseases of the married group were higher than those of the unmarried group with statistically significant difference(P＜0.05).Conclusion The mastery degree of reproductive health knowledge in artificial abortion persons form foreign female workers of Baoan District in Shenzhen City is higher,but they generally lack of the knowledge of sexually transmitted diseases.In addition to strengthening propaganda and education work in this area,it has become a prominent problem to provide post-abortion care services for specific populations＜35 years old,high school and below and the unmarried. 2018 Vol. 25 (23): 182-185 [Abstract] ( 118 ) HTML (39 KB)  PDF  (0 KB)  ( 25 ) 186 Study on the current status of HPV infection and age stratification in 2915 women XU Wen-jin;OU Feng-rong;WANG Hong;ZHOU Xiao-li;YAN Hua Objective To analyze the the current status of human papilloma virus(HPV)infection and age stratification in 2915 women to provide the theoretical basis for the prevention and treatment of cervical cancer.Methods Cervical exfoliative cells and detection results in 2915 women voluntarily carrying out HPV infection test from January 2016 to July 2017 were collected.HPV typing was tested using fluorescence PCR technology,and 15 types of HPV subtypes could be detected.Results The positive rate of HPV was 22.23%(648/2915).They were divided into the 4 age groups(＜30 years old,30-39 years old,40-49 years old,and≥50 years old)to carry out analysis.The HPV positive rate of the 4 groups was different,and the age group(≥50 years old)was the highest,and there was a significant difference between the ≥50 years old group and the other 3 groups respectively(χ2=3.94,6.21,4.34,P＜0.05).Age stratification analysis showed that the positive rate of HPV in each age group was"U"curve.Among 15 HPV subtypes of infection detected,the top 2 was HPV18,16 respectively,and the positive rate of HPV in HPV18 and 16 was higher in＜30 years old and≥50 years old.Conclusion Female HPV infection is related to age stratification.Young women,perimenopausal women and above-mentioned women need to be highly alert to the risk of HPV infection. 2018 Vol. 25 (23): 186-188 [Abstract] ( 135 ) HTML (35 KB)  PDF  (0 KB)  ( 26 ) 189 Analysis of irrational application of paediatric antimicrobial drugs in our hospital YUAN Yan-xue Objective To analyze of irrational application of pediatric antimicrobial in our hospital to provide a reliable basis for promoting the rational use of antimicrobial drugs.Methods A total of 1000 children with antimicrobial drugs treated outpatient department of pediatrics or inpatient department in our hospital from January to December 2015 were selected,the prescriptions of antimicrobial drugs for 1000 pediatric patients were reviewed,the irrational use of antimicrobial drugs was counted,the reasons for irrational use of antimicrobial drugs were analyzed and targeted pharmaceutical intervention measures were conducted.Results 1692 pediatric prescriptions were prescribed in 1000 pediatric patients,there were 34 prescriptions for irrational use of antibiotics,and it accounted for 2.01%.The reasons for the irrational use of antibacterials include the time of administration is unreasonable,unreasonable dosage,drug treatment unreasonable,no clear sign medication,drug compatibility unreasonable,the choice of solvents unreasonable,and the occupation ratio was 11.76%,5.88%,14.71%,17.65%,41.18%,8.82%respectively.Conclusion The application of antimicrobial agents in department of pediatrics,there are still many unreasonable applications,it is necessary to understand the causes of irrational use of antimicrobial drugs in the clinic,and rational drug intervention measures should be implemented to promote rational use of antibacterial drugs in department of pediatrics. 2018 Vol. 25 (23): 189-191 [Abstract] ( 114 ) HTML (31 KB)  PDF  (0 KB)  ( 22 ) 192 Cause analysis and prevention countermeasures of a patient who left a gastric tube and strayed into trachea without typical symptoms at home WANG Ai-jun Members of the pipeline team in our hospital appeared a serious case of“aspiration pneumonia and atelectasis”caused by a gastric tube entering the trachea without typical symptoms during the door-to-door service of providing pipeline replacement for discharged home patients with tubes.The patient was once delirious.This paper analyzes the causes of gastric tube straying into trachea from five aspects：anatomical factors,patient factors,gastric tube factors,nurse factors,and management factors,and makes preventive measures based on the causes,which provides reference for solving similar problems in the future and also has certain reference for further clinical nursing work of pipelines. 2018 Vol. 25 (23): 192-195 [Abstract] ( 126 ) HTML (45 KB)  PDF  (0 KB)  ( 13 ) 196 One case analysis of dosage adjustment for deep vein thrombosis(DVT)treatment with warfarin oral analysis of dosage adjustment of one patient with lower limb venous thrombosis treated by oral warfarin SUN Zhan-jun;PEI Ping;ZHAO Gui-zhu Warfarin is a double coumarin oral anticoagulant used to prevent and treat thromboembolic diseases.In clinical application,doctors usually adjust the dosage of warfarin according to the international standard ratio of prothrombin time(INR value).This article records in detail the process of medication adjustment of a patient with lower limb venous thrombosis treated with warfarin.In this case,pharmacists put forward a reasonable plan for warfarin dosage adjustment based on changes in the INR value of patients,so as to maintain the INR value within the required range.This case proves that the role of pharmacists cannot be ignored from the formulation of warfarin medication plan to the selection of deployment methods. 2018 Vol. 25 (23): 196-198 [Abstract] ( 139 ) HTML (35 KB)  PDF  (0 KB)  ( 27 ) 199 Application of detail nursing in nursing care of patients with fixed correction LI Xi-ru;FENG Jin-lan;ZOU Hui Objective To study the application effect of detail nursing in nursing care of patients with fixed correction.Methods From July 2016 to July 2017,200 patients who underwent orthodontic fixation in our hospital were selected as the research data.The patients were divided into two groups according to the digital randomization method,100 cases in each group.The control group was received routine fixed correction nursing measures,the study group was used details of care.Two groups of patients with the effect and safety of care were compared.Results The total incidence of adverse events in the study group was 3% (3 cases),the incidence of adverse events in the control group was 28%(28 cases),and the incidence of adverse events in the study group was lower than that in the control group(P＜0.05）.The total nursing satisfaction of the study group was 97% (97 cases).The nursing satisfaction of the control group was 81%(81 cases).The nursing satisfaction of the study group was higher than that of the control group (P＜0.05）.Conclusion Nursing care can effectively reduce the incidence of adverse events such as enamel demineralization,loose brackets,gingivitis and dental caries during fixed orthodontic treatment,improve nursing safety,improve nursing effect and nursing satisfaction in the fixed correction of patient care to promote the application. 2018 Vol. 25 (23): 199-201 [Abstract] ( 113 ) HTML (33 KB)  PDF  (0 KB)  ( 27 ) 202 Effect analysis of humanized nursing measures in general surgery nursing HE Yan Objective To explore the effect of humanized nursing on patients undergoing general surgeries.Methods Forty-two surgical patients performed with general surgeries in our hospital from April 2016 to July 2017 were selected for analysis.They were divided into two groups in double blinding：observation group and control group,21 cases in each group.The control group was given conventional nursing intervention,the observation group was given humanized nursing intervention.Visual analogue scale(VAS)scoring was used to compare and observe the pain of the two groups.The patient′s satisfaction on nursing was through questionnaires.Results VAS score of the observation group was lower than that of the control group and the hospital stay was shorter than that of the control group with statistical significance(P＜0.05）.The total incidence of complications in the observation group was lower than that of the control group,and the satisfaction on nursing was higher than that of the control group,which were statistical significantly (P＜0.05）.Conclusion The application of humanized nursing intervention to general surgery patients in nursing can effectively reduce the incidence of postoperative complications,relieve the pain,shorten the hospital stay,which is of great significance on program promotion. 2018 Vol. 25 (23): 202-204 [Abstract] ( 132 ) HTML (33 KB)  PDF  (0 KB)  ( 23 ) 205 Application effect observation of PICC in the concurrent chemoradiation of nasopharyngeal carcinoma LU Dan Objective To investigate the application effect of peripherally inserted central catheter(PICC)in the concurrent chemoradiation of nasopharyngeal carcinoma patients.Methods Ninety-three nasopharyngeal carcinoma patients who underwent radiotherapy and chemotherapy in the same period from September 2015 to August 2017 were selected and divided into observation group (n=63)and control group (n=30)according to the patient′s will.The PICC was used in the observation group,and the peripheral venous indwelling needle was used in the control group.Before and 3 months after radiotherapy and chemotherapy in the same period,the quality of life of the two groups was evaluated by the EORTC QLQ-C30 questionnaire.The weight of the patients before and after treatment was recorded,and the incidence of complications of intravenous infusion during the treatment were recorded.Results Before treatment,there was no significant difference in the scores of the quality of life between the two groups(P＞0.05).In terms of the functional areas and the overall health status of the two positive indicators of quality of life,the scores after treatment in both groups were lower than before treatment.Three months after treatment,the scores of the observation group were higher than those of the control group with statistical significance (P＜0.05）.In terms of the negative quality of life index in the symptom scope,the scores of fatigue,nausea,vomiting and insomnia in the observation group were lower than those in the control group after treatment(P＜0.05）,but in terms of pain,dyspnea,constipation,diarrhea,loss of appetite and economic burden,there was no significant difference between the two groups (P＞0.05）.After treatment,the body weight of the two groups were decreased compared with those before treatment with significant differences(P＜0.05）.However,the percentage of body weight change in the observation group after treatment was higher than that in the control group with a statistical difference(P＜0.05）.After treatment,the body weight of both groups were lower than before treatment,but the weight loss in the observation group was more better than that in the control group.With regards to the incidence of complications,the incidence of phlebitis,leakage of chemical drugs,and repeated venipuncture in the observation group was lower than that in the control group with a significant difference (P＜0.05）.Conclusion The use of PICC in concurrent radiochemotherapy for nasopharyngeal carcinoma is more beneficial to the improvement of the quality of life and nutrition compared with the traditional intravenous indwelling needle and has fewer complications during infusion. 2018 Vol. 25 (23): 205-208 [Abstract] ( 109 ) HTML (43 KB)  PDF  (0 KB)  ( 27 ) 211 The value of clustering care in the prevention of neonatal ventilator-associated pneumonia YANG Hui-e Objective To investigate the clinical value of clustering care for neonatal ventilator-associated pneumonia.Methods 80 neonates treated with ventilators treated in our hospital from January to December 2017 were selected and divided into two groups according with different nursing methods,40 cases in each group.The observation group was implemented clustered nursing interventions,and the control group was implemented routine care,including general nursing,dietary intervention,health education upon admission and discharge,and regular visits.Then the invasive ventilator treatment and total length of stay between the two groups with newborn infants,the treatment of neonatal jaundice and the use of blue light,and the improvement of clinical symptoms in both groups were compared.Results The using of invasive ventilator,the total length of stay time in the observation group was shorter than that in the control group(P＜0.05）.The recovery time of the neonatal jaundice,the time of blue light irradiation in the observation group was shorter than that in the control group (P＜0.05）.The time of fever subsidence,time with dry and wet lung sound and the time of shortness breath in the observation group were significantly earlier than that in the control group,the differences were statistically significant(P＜0.05).Conclusion The implementation of bundled care for neonatal pneumonia can short the number of children,and the ventilator time and length stay time,so it can reduce the occurrence of pathological jaundice and relieve the clinical symptoms. 2018 Vol. 25 (23): 211-211转214 [Abstract] ( 115 ) HTML (37 KB)  PDF  (0 KB)  ( 24 ) 212 Study on the relationship between two different nursing methods and infection in central venous catheterization LI Ying-qin;ZHANG Wen-zhi Objective To analyze the effect of infection on patients under the different nursing methods of central venous catheterization.Methods A total of 166 patients undergoing central venous catheterization from January 2015 to January 2017 in our hospital were selected as observation subjects.The patients were randomly entered into the control group and the experimental group by computer input,83 cases in each group.The control group patients were given routine nursing care,patients in the experimental group were nurtured on the basis of routine care.The time of catheterization and the infection were compared under two kinds of nursing.Results In the observation group,there were 19 cases of skin changes in central venous catheterization cases,the rate of change was 22.9%,4 cases of infection,the infection rate was 4.8%.In the control group,there were 24 cases of changes in the skin of central venous catheterization,the rate of change was 28.9%,13 cases were infected and the infection rate was 15.7%.According to the two different nursing methods,skin changes in the puncture site of the observation group were lower and the infection rate was lower,the difference was statistically significant(P＜0.05）.Conclusion During the course of catheterization of central venous catheter,further nursing care can be carried out to further reduce the infection caused by catheterization,which is worth to be used in clinical central venous catheterization. 2018 Vol. 25 (23): 212-214 [Abstract] ( 114 ) HTML (30 KB)  PDF  (0 KB)  ( 27 ) 215 Effectiveness of application of diversified nursing modes in nursing care of patients with diabetes mellitus complicated with coronary heart disease WU Dong-mei Objective To analyze the effect of application of diversified nursing in nursing care of patients with diabetes mellitus complicated with coronary heart disease.Methods Altogether 70 diabetes mellitus patients complicated with coronary heart disease who were treated in our hospital from August 2017 to February 2018 were divided into the control groups and the observation group by using computer random coding,35 casea in each group.The control group was received routine nursing and the observation group was received diversified nursing, respectively.The changes of blood glucose and the quality of life at post-nursing three months were compared between the two groups.Results There was no statistically significant difference between the two groups in the level of fasting blood glucose and postprandial blood glucose before nursing(P＞0.05）.The level of post-nursing fasting blood glucose and postprandial blood glucose at post-nursing two hours were (6.22±1.05)mmol/L and (8.56±1.12)mmol/L,which were lower than those of the control group([7.15±1.12]mmol/L and[10.54±1.24]mmol/L）,with statistically significant difference(P＜0.05）.At post-nursing three months,the emotional function score,mental health score,activity score,social function score,body pain score,physical limitation score,physiological function score and total health score were(86.65±2.34),(85.52±2.01),(88.69±2.34),(87.58±1.13),(85.55±2.11),(86.64±2.30),(85.56±2.13)and(89.59±2.01)scores,higher than those of the control group （[73.26±2.26],[75.52±1.15],[74.58±2.31],[76.62±2.22],[73.35±2.010],[75.06±2.19],[74.59±2.11]and[(73.39±2.37]scores）,with statistically significant differences(P＜0.05）.The level of post-nursing fasting blood glucose and postprandial blood glucose at post-nursing two hours of the two groups were lower than those before nursing,with statistically significant difference(P＜0.05）.Conclusion Diversified nursing can reduce the blood glucose level and improve the quality of life for diabetes mellitus patients complicated with coronary heart disease. 2018 Vol. 25 (23): 215-217转220 [Abstract] ( 110 ) HTML (35 KB)  PDF  (0 KB)  ( 26 ) 218 Application effects of comprehensive nursing care in the patients with primary angle-closure glaucoma after filtration surgery CHEN Yu;WANG Jing;ZHANG Yu;SHI Yi-lu;LI Lin Objective To investigate the application effect of comprehensive nursing on primary angle-closure glaucoma after filtration surgery.Methods 128 patients with primary angle-closure glaucoma who underwent surgery in our hospital from January 2016 to February 2017 were selected.Patients were randomly divided into control group and experimental group by random number table method,64cases in each group.The control group was given routine nursing care,and the experimental group was given comprehensive nursing measures.The self-management efficacy scores and the quality of life of patients in the two group were compared.Results The self-management efficacy scores of the two groups before nursing were not statistically significant(P＞0.05）;after 3 months of nursing,the self-management efficacy score in the experimental group([32.92±7.53]scores)was higher than that in the control group([26.47±5.94]scores),and the difference was statistically significant(P＜0.05);after 3 months of nursing,the quality of life in the experimental group([62.27±4.37]scores)was higher than that in the control group ([54.65±3.48]scores),and the difference was statistically significant(P＜0.05).Conclusion Comprehensive nursing care can enhance the self-management efficacy of the patients with primary angle-closure glaucoma,improve postoperative activities of daily living,the quality of life of patients with primary angle-closure glaucoma after surgery,which has an important clinical significance in clinical practice. 2018 Vol. 25 (23): 218-220 [Abstract] ( 128 ) HTML (33 KB)  PDF  (0 KB)  ( 22 )

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