乙酰半胱氨酸颗粒治疗百日咳的临床效果

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Abstract Objective To investigate the clinical effect of Acetylcysteine Granules in the treatment of children with whooping cough.Methods A total of 120 children patients with whooping cough who were admitted to the department of infectious diseases in our hospital from January to December,2017 were selected as objects.According to the random pairing design,they were divided into the treatment group(60 cases)and the control group(60 cases).In the control group,Erythromycin or Azithromycin was used to prevent infection,Bromhexine Hydrochloride or Ambroxol for relieving cough and phlegm,Budesonide,Terbutaline oxygen inhalation and sucking care treatment.The treatment group received oral Acetylcysteine Granule on the basis of conventional treatment in the control group.The clinical symptoms,time of hospital stay,and total effective rates were compared between the two groups.Results The duration of spastic cough,the duration of cholestre-like echo,the duration of vomiting after cough,the duration of paroxysmal cyanosis,the disappearance of pulmonary rales,and the time of hospital stay in the treatment group after treatment were shorter than those in the control group,and the differences were statistically significant(P＜0.05).The total effective rate in the treatment group was higher than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion On the basis of conventional treatment,further oral administration of Acetylcysteine Granules in the treatment of whooping cough can significantly reduce the clinical symptoms and shorten the course of the disease in children.The drug is convenient for oral administration,safe,and easy to accept,which is worthy of clinical promotion.

Key words： Acetylcysteine Whooping cough Spasmodic cough Clinical efficacy

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REN Xiao-mei. Clinical effect of Acetylcysteine Granules in the treatment of whooping cough[J]. 中国当代医药, 2018, 25(23): 162-165.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I23/162

[1]	王静敏.百日咳的研究现状[J].国际流行病学传染病学杂志，2001，28（2）：67-70.
[2]	Crowcroft NS，Pebody RG.Recent developments in pertussis[J].Lancet，2006，367（9526）：1926-1936.
[5]	徐勇胜.百日咳临床特征研究进展[J].中国实用儿科医学杂志，2016，31（9）：712-714.
[6]	骆鹏，张庶民.百日咳免疫控制研究进展[J].中国公共卫生，2010，26（5）：651-653.
[7]	徐颖华.百日咳实验室诊断的研究进展[J].中国生物制品学杂志，2005，18（3）：264-266.
[8]	Lynfield R，Schaffner W.Can we conquer coqueluche[J].J Infect Dis，2014，209（Suppl 1）：1-3.
[3]	Matthias J，Pritchard PS，Martin SW，et al.Sustained transmission of pertussis in vaccinated，1-5-year-old children in a preschool，Florida，USA[J].Emerg Infect Dis，2016，22（2）：242-246.
[4]	Wood N，McIntyre P.Pertussis：review of epidemiology，diagnosis，management and prevention[J].Paediatr Respir Rev，2008，9（3）：201-212.
[9]	林善锬.当代肾脏病学[M].上海：上海科技教育出版社，2001：166-176.
[10]	顾勇，施雪枫.大剂量重组促红细胞生成素治疗血透患者贫血的疗效与安全性[J].中国临床药学杂志，2004，13（2）：69-72.
[11]	孙志坤，陈生弟.促红细胞生成素抗神经原凋亡的信号传导通路[J].中国药理学通报，2006，22（12）：1429-1432.
[12]	王春梅.吡非尼酮和N-乙酰半胱氨酸对小鼠肺纤维化中RELM-beta表达的影响[D].长沙：中南大学，2012.
[13]	吴丹遐，陈强，申昆玲.百日咳的临床研究进展[J].中国当代儿科杂志，2016，18（9）：897-902.
[14]	闫莉，黄英，叶泽慧.百日咳与百日咳综合征的诊治分析[J].重庆医科大学报，2016，41（4）：355-359.
[15]	胡云鸽，刘泉波.儿童百日咳247例临床特点及重症百日咳危险因素分析[J].中华儿科杂志，2015，53（9）：684-689.