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| Effect of Atorvastatin in the treatment of X syndrome combined with hyperlipidemia |
| ZHANG Di SONG Zhan-chun ZHAO Yue-chao TIAN Mi |
| The First Department of Cardiovascular Medicine,Central Hospital of Fushun City,Liaoning Province,Fushun 113006,China |
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Abstract Objective To investigate the effect of Atorvastatin in the treatment of X syndrome combined with hyperlipidemia.Methods A total of 94 patients with X syndrome and hyperlipidemia treated in our hospital from October 2016 to October 2017 were selected as subjects and were randomly divided into the control group (47 cases)and the observation group(47 cases).The control group was given routine treatment and the observation group was treated with Atorvastatin on the basis of the routine treatment.Biochemical indicators,cardiac anxiety scale (CAQ)score and cardiac evaluation indexs before and after treatment were compared between two groups,clinical effect and safety were also compared between two groups.Results The C-reactive protein (CRP),total cholesterol,triglyceride and low-density lipoprotein cholesterol in two groups after treatment were lower than those before treatment,the paraoxonase-1 and high-density lipoprotein cholesterol were higher than those before treatment,and the differences were statistically significant(P＜0.05).The CRP,total cholesterol,triglyceride and low-density lipoprotein cholesterol in the observation group after treatment were lower than those in the control group,the paraoxonase-1 and high-density lipoprotein cholesterol were higher than those in the control group,and the differences were statistically significant(P＜0.05).The score of CAQ and frequency of chest pain in two groups after treatment were lower than those before treatment,the time of exercise plate test and the maximum time of S segment depression were longer than those before treatment,and the differences were statistically significant(P＜0.05).The score of CAQ and frequency of chest pain in the observation group after treatment were lower than those in the control group,the time of exercise plate test and the maximum time of S segment depression were longer than those in the control group,and the differences were statistically significant(P＜0.05).The total effective rate of the observation group was 97.9%,which was higher than that of the control group(83.0%),and the difference was statistically significant(P＜0.05).There was no statistically significant difference in the safety of medication between two groups (P＞0.05).Conclusion Atorvastatin can effectively improve serum lipid level and cardiac function in patients with X syndrome and hyperlipidemia,which has significant effect.
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