阿替普酶联合丁苯酞注射液治疗急性脑梗死的效果

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Abstract Objective To investigate the effect of Alteplase combined with Butylphthalide Injection in the treatment of acute cerebral infarction and its effect on hemorheology and neurological function.Methods Eighty patients with acute cerebral infarction admitted to our hospital from January 2016 to October 2017 were selected as objects and divided into the control group(40 cases)and the observation group(40 cases)according to the random number table method.The control group was treated with Alteplase Thrombolysis and the observation group was treated with Butylphthalide Injection on the basis of the control group.Hemorheological indicators,neurological factors of S-100 protein(S100B),myelin basic protein (MBP),and clinical efficacy before treatment and 7 d after treatment between two groups were compared.Results The plasma viscosity and platelet aggregation rate of two groups after treatment were lower than those before treatment,and the differences were statistically significant(P＜0.05).The plasma viscosity and platelet aggregation rate in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P＜0.05).The levels of S100B and MBP of two groups after treatment were lower than those before treatment,and the differences were statistically significant(P＜0.05).The levels of S100B and MBP in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P＜0.05).The total effective rate of the observation group was 92.50%,which was higher than that of the control group(75.00%),and the difference was statistically significant(P＜0.05).Conclusion Alteplase combined with Butylphthalide Injection has significant effect on acute cerebral infarction,which can improve hemorrheology and neurological function,and is worth of promotion.

Key words： Acute cerebral infarction Alteplase Butylphthalide Hemorheology Neurological function

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	ZENG Hong-liang
	ZENG Xiang-jun

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ZENG Hong-liang,ZENG Xiang-jun. Effect of Alteplase combined with Butylphthalide Injection in the treatment of acute cerebral infarction[J]. 中国当代医药, 2018, 25(23): 148-150转154.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I23/148

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