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| Clinical efficacy and safety of tirofiban in patients with acute cerebral infarction undergoing stenting |
| LI Bing-run LUO Sai-hua JIANG Qing-yan |
| The Second Department of Neurosurgery,Lianjiang People′s Hospital in Guangdong Province,Lianjiang 524400,China |
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Abstract Objective To investigate the clinical efficacy and safety of tirofiban in patients with acute cerebral infarction undergoing stenting.Methods The clinical data of 31 patients with acute cerebral infarction admitted to our hospital from January 2016 to November 2017 who were treated with tirofiban during stenting were retrospectively analyzed.according to whether tirofiban was used during the operation,they were divided into control group (12 cases)and observation group (19 cases).The control group was treated with stenting alone,while the observation group was treated with tirofiban during stenting.The platelet aggregation level,nihss and bi scores and the incidence of adverse reactions were compared between the two groups before and after treatment.Results Before treatment,there was no significant difference in platelet aggregation between the two groups (P＞0.05).The platelet aggregation level of 24 h was significantly lower than that before treatment in two groups,and the platelet aggregation level in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).Before surgery,there was no significant difference in NIHSS score and BI score between the two groups.At 3 weeks after surgery,the NIHSS scores of the two groups were lower than those before surgery,and the BI scores of the two groups were higher than those before surgery 3 months after surgery,the difference was statistically significant(P＜0.05).NIHSS scores in the observation group were lower than those in the control group 3 weeks after surgery,and BI scores were higher than those in the control group 3 months after surgery,the difference was statistically significant(P＜0.05).There was 1 case of symptomatic bleeding in the control group,1 case of asymptomatic bleeding in the study group,and no death.There was no statistical difference in the incidence of intracranial hemorrhage between the two groups after treatment(P＞0.05).Conclusion Tirofiban can reduce platelet aggregation rate,improve vascular recanalization rate,improve the prognosis of patients with acute cerebral infarction during stenting,and has high safety.
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