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2020 Vol. 27, No. 11
Published: 2020-04-18
 
 
4 Pathological changes and expression of interleukin-17 in rat model of chronic obliterative bronchiolitis after heterotopic tracheal transplantation
WU Wei-dong； HUANG Lin； WU Wei-han； ZHU Yong
Objective To investigate the pathological changes and the expression of IL-17 (IL-17) in different stages of chronic bronchiolitis obliterans model after heterotopic tracheal transplantation in rats.Methods Twenty-four cleangrade SD rats were selected, of which 6 were brown Norway (BN) and 18 were Lewis.Twelve Lewis rats were randomly selected into the control group, and the remaining six Lewis rats and six BN rats were included into the observation group.The BN rats in observation group provided trachea, Lewis rats received trachea；and the 12 Lewis rats in control group were both donor and receptor.The cartilage injury rate, lymphocyte count, incidence of bronchiolitis obliterans and the level of IL-17 were compared between the two groups.Results After transplantation, the incidence of bronchiolitis obliterans in the observation group was 100.00%, higher than that in the control group (0.00%), with statistically significant difference (P＜0.05).There was no statistically significant difference in the cartilage damage rate between the two groups on the 7th day after transplantation (P＞0.05).On the 14th and 28th days after transplantation, the cartilage damage rates in the observation group were higher than those in the control group, with statistically significant differences (P＜0.05).After 7, 14 and 28 days of transplantation, the lymphocyte counts in the observation group were more than those in the control group, with statistically significant differences (P＜0.05).There were no statistically significant differences in the levels of IL-17 between the two groups on the 7th and 14th days after transplantation (P＞0.05).The level of IL-17 in the observation group was higher than that in the control group on the 28th day after transplantation,with statistically significant difference (P＜0.05).Conclusion Through the establishment of the model of chronic rejection of ectopic trachea in rats, it is suggested that the level of IL-17 in rats increased after the transplantation of ectopic trachea, and the mechanism of occlusive inflammatory response induced by IL-17 should be further studied.
2020 Vol. 27 (11): 4-6转11 [Abstract] ( 72 ) HTML (35 KB)  PDF  (0 KB)  ( 9 )
7 Observation of clinicopathologic tissue and imaging features of gastric leiomyoma and gastric stromal tumors
ZHENG Yi-hong; LAN Tian; HUANG Xiao-mei; LI Wei-song
Objective To study the difference of clinicopathological and imaging features between gastric leiomyoma and gastric stromal tumors.Methods A total of 40 patients with gastric leiomyoma were treated in Ganzhou Municipal Hospital and the First Affiliated Hospital of Gannan Medical University from January 2014 to May 2019 were selected as gastric leiomyoma group.Another 40 patients with gastrointestinal stromal tumors treated in Ganzhou Municipal Hospital and the First Affiliated Hospital of Gannan Medical University at the same time were selected as gastric stromal tumor group.The imaging and pathological datas of the patients between the two groups were compared.Results The proportions of defibrin (Desmin) (+), anti-smooth muscle antibody (SMA) (+) and cell proliferation marker Ki67 (+)in the gastric leiomyoma group were higher than those in the gastric stromal tumor group, and the proportions of protooncogenes CD117 (+), proto-oncogenes CD34 (+) and Dog-1 (+) in the gastric leiomyoma group were lower than those in the gastric stromal tumor group, with statistically significant differences (P＜0.05).The pathological cells of the gastric stromal tumor group were analyzed, and the results showed that the proportion of epithelioid cells was (13.94±2.03)%, the proportion of spindle cells was (58.96±2.19)%, and the proportion of mixed cells was (24.36±2.15)%.Microscopic examination of the gastric leiomyoma showed that the tumors were located in the submucosa of the stomach,with clear boundaries and tumor cells arranged in bundles.The CT value of gastric leiomyoma was mostly 40-60 Hu,which showed uniform enhancement after enhancement.The density of CT plain scan of gastric stromal tumor was not uniform, and the enhancement of mass in enhanced scan was obvious, when the necrosis was large, the strengthening was not uniform.There was no significant difference in the echo characteristics between the two groups (P ＞0.05).The echo uniformity of the gastric leiomyoma group was higher than that of the gastric stromal tumor group, and the echo not uniformity was lower than that of the gastric stromal tumor group, and the differences were statistically significant (P＜0.05).Conclusion There were differences in tissue density uniformity, Desmin, SMA, CD117, Dog-1 and CD34 in patients with gastric leiomyoma and gastric stromal tumor, the results of tissue density uniformity, Desmin,SMA, CD117, Dog-1 and CD34 immunohistochemistry can be used as the important basis for differential diagnosis.
2020 Vol. 27 (11): 7-11 [Abstract] ( 98 ) HTML (43 KB)  PDF  (0 KB)  ( 6 )
12 Expression and clinical significance of interferon-γ, osteopontin and interleukin-18 in serum and sputum supernatant from patients with pulmonary tuberculosis
DU Wei-qin; REN Jian-bin▲
Objective To explore the expression and clinical significance of interferon-γ (IFN-γ), osteopontin (OPN)and interleukin-18 (IL-18) in serum and sputum supernatant from patients with pulmonary tuberculosis.Methods Serum and sputum samples were collected both from 89 patients with pulmonary tuberculosis (pulmonary tuberculosis group) and 30 healthy individuals (healthy control group) in our hospital from November 2016 to December 2018.The levels of the three cytokines mentioned above were respectively detected by double antibody sandwich enzyme linked immunosorbent assay (ELISA) technique and then the levels of IFN-γ, OPN, and IL-18 between the two groups were compared.Results The levels of IFN-γ, OPN, and IL-18 in the serum and sputum supernatant of the pulmonary tuberculosis group were higher than those of the healthy control group, and the differences were statistically significant (P＜0.05).Conclusion It is of great significance for the auxiliary clinical diagnosis and the judgment of the disease prognosis due to the elevation of the IFN-γ, OPN, and IL-18 in serum and sputum supernatants from patients with pulmonary tuberculosis.
2020 Vol. 27 (11): 12-15 [Abstract] ( 75 ) HTML (39 KB)  PDF  (0 KB)  ( 13 )
16 Changes study of 5-hydroxytryptamine and 5-hydroxytryptamine 2B receptor in the patient with irritable bowel syndrome
SUN Yong-hong; ZHANG Ye; WANG Yu; WANG Fu-cheng; LI Qing; SUN Xiu-li; ZHANG Jing
Objective To observe the changes of 5-hydroxytryptamine (5-HT) and 5-HT2B receptor in the patients with irritable bowel syndrome (IBS).And to explore the role of 5-HT and 5-HT2B receptor in the pathogenesis of IBS.Methods From January 2016 to may 2017, 48 patients with diarrhea type IBS (IBS-D) and constipation type IBS (IBSC) were selected from the Department of Gastroenterology, Dalian Friendship Hospital, including 26 cases of IBS-D patients (IBS-D group), 22 cases of IBS-C patients (IBS-C group).In addition, those undergoing colonoscopy for polyps or cancer surveillance with negative results were included in the control group (28 cases).The abdominal symptom scale was used to score the subjects, and the Plasma 5-HT and 5-HT2B receptor concentrations were detected by ELISA.Specimens were obtained from the ascending colon during the colonoscopy, and the expression level of 5-HT mRNA and 5-HT2B receptor mRNA in colonic mucosa were detected by reverse transcription PCR.The relationship between 5-HT and 5-HT2B receptor levels and abdominal symptoms were calculated.Results The scores of abdominal symptoms in IBS-D and IBS-C groups were higher than those in the control group, the differences were statistically significant (P＜0.05).The plasma concentrations of 5-HT and 5-HT2B receptor in IBS-D and IBS-C groups were higher than those in the control group, the differences were statistically significant (P＜0.05).The expression of 5-HT and 5-HT2B receptor mRNA in colonic mucosa of IBS-D and IBS-C group were higher than those of control group, the differences were statistically significant (P＜0.05).Spearman analysis showed that the expression of plasma 5-HT in IBS-D and IBS-C group were positively correlated with abdominal symptom score (r=0.82, 0.79；P＜0.05).The plasma 5-HT2B receptor expression in IBS-D and IBS-C groups were positively correlated with abdominal symptom scores (r=0.78, 0.76；P＜0.05).There was no correlation between the expression of 5-HT and 5-HT2B receptor and abdominal symptom score in the control group (P＞0.05).Conclusion T5-HT and 5-HT2B are significantly increased in IBS patients, and plasma 5-HT and 5-HT2B are positively correlated with the abdominal symptom score of IBS patients, suggesting that 5-HT and 5-HT2B receptors may be involved in the occurrence of abdominal pain in IBS patients.
2020 Vol. 27 (11): 16-19 [Abstract] ( 75 ) HTML (47 KB)  PDF  (0 KB)  ( 12 )
20 Research progress in damage of nervous system by inhaolable particles in sand weather
PI Qi-xing; LIU Yan-li; LI Chen; WU Xue-qin; MA Jian-xiu
The decline in air quality caused by dust events have threathened the human health in relevent area which are widely concerned.There was a common recogention the dust exposure has negative impact on respiratory and cardiovascular systems, accroding to extensive and in-depth studies, it also lesioned nervous and reprodutctive systems.This paper reviews the latest researches on the lesion in cognitive behavioral ability, peripheral nerve function and neurodevelopment of nervous system caused by inhaolable particles in sand weather.
2020 Vol. 27 (11): 20-22 [Abstract] ( 75 ) HTML (34 KB)  PDF  (0 KB)  ( 9 )
23 Research progress of restricting factors analysis and countermeasures of peripherally inserted central catheter application in chemotherapy patients
LI Dong-mei
Peripherally inserted central catheter (PICC) has been widely used in clinic, and peripheral vascular protection plays a crucial role when tumor patients receive multiple courses of intravenous chemotherapy drugs, but there are still quite a number of clinical chemotherapy patients who prefer to use peripheral superficial vein indwelling or even scalp steel needle puncture instead of PICC catheterization.Through extensive literature, this paper reviews the restrictive factors and related countermeasures that may affect the use of PICC in chemotherapy patients from the perspective of patients, medical care and management.The aim is to enable medical staff and patients to fully understand the "superiority of a needle therapy" in PICC intravenous chemotherapy, in order to promote medical staff to correctly guide patients to choose a PICC catheter reasonably according to their own situation and willingness, and provide safe vascular access protection for the implementation of intravenous chemotherapy.
2020 Vol. 27 (11): 23-26 [Abstract] ( 71 ) HTML (43 KB)  PDF  (0 KB)  ( 8 )
27 Research progress of Bevacizumab combined with epidermal growth factor receptor tyrosine kinase inhibitor in treatment of non-small cell lung cancer
ZHANG Xin-yi ; ZHANG Mei-yun▲
Lung cancer is the most common malignancy with the highest morbidity and mortality worldwide, most of which are non-small cell lung cancer (NSCLC).Epidermal growth factor receptor tyrosine kinase inhibitors (EGFRTKI) drugs significantly prolonged the survival time of NSCLC patients, but most patients developed drug resistance.Bevacizumab inhibited the activity of human vascular endothelial growth factor and inhibited the formation of blood vessels effectivly, which has better antitumor effect.Bevacizumab and EGFR-TKI drugs act on different tumor growth pathways, and these two drugs have potentially complementary mechanisms to control tumor.The combined treatment of NSCLC has sufficient theoretical basis and application prospect.This article reviews the research progress of Bevacizumab and EGFR-TKI in the treatment of NSCLC.
2020 Vol. 27 (11): 27-30 [Abstract] ( 95 ) HTML (34 KB)  PDF  (0 KB)  ( 11 )
31 Research progress in the detection of leukocytes, platelets, C-reactive protein and procalcitonin in the diagnosis of neonatal infectious diseases
WU Huan; WANG Xiao-lin
Neonatal infectious diseases refer to diseases caused by bacterial, viral, mycoplasmal, fungal and other pathogens in the neonatal period, among which bacterial infections are the most common.Despite significant improvements in health conditions, newer and more effective antibiotics have emerged, but the incidence and mortality of infectious diseases remain high.Globally, infection is the main cause of death and disability in newborns, especially in middle-low income countries.Early diagnosis is the premise of treatment, but currently the laboratory is not able to provide indicators with high specificity and sensitivity for early diagnosis of infectious diseases.This article reviews the research progress of clinically used infection indicators such as white blood cells, platelet, C-reactive protein and procalcitonin in the diagnosis of neonatal infectious diseases.
2020 Vol. 27 (11): 31-34 [Abstract] ( 78 ) HTML (41 KB)  PDF  (0 KB)  ( 10 )
35 Advances in clinical research of cerebral amyloid angiopathy-related inflammation
YANG Jing； LI Xiao-feng
Cerebral amyloid angiopathy-related inflammation is an uncommon subtype of cerebral amyloid angiopathy,manifested as cognitive impairment, mental and behavioral abnormalities, focal neurological deficits, and epilepsy.Clinical diagnosis is often based on clinical manifestations, cerebrospinal fluid, gene and imaging examinations.Cerebral amyloid angiopathy-related inflammation mainly includes two pathological types: inflammatory cerebral amyloid angiopathy and Aβ-related angiitis, which can often be improved after treatment with hormones and immunosuppressants.This article consults the latest literature data, summarizes and analyzes its etiology, pathogenesis, clinical manifestations, auxiliary examinations, diagnosis and differential diagnosis, treatment and prognosis, so as to provide references for clinical diagnosis and treatment of the disease.
2020 Vol. 27 (11): 35-37转41 [Abstract] ( 72 ) HTML (37 KB)  PDF  (0 KB)  ( 13 )
38 Application effect of cognitive behavior intervention in patients with chronic obstructive pulmonary disease
LIN Zhuang-Guo； CHEN Yong-Kang； XU Pei-Na； YAO Gui-Yi； KUANG Jin-Bo
Objective To investigate the application effect of cognitive behavioral intervention in patients with chronic obstructive pulmonary disease (COPD).Methods A total of 200 COPD patients who were in outpatient or hospitalized at the Yuexiu District Hospital of Chinese Medicine Hospital in Guangzhou from January 2017 to June 2018 were selected as the study subjects.According to the random numer table method, they were divided into 100 cases in the research group and 100 cases in the control group.Both groups performed routine internal medicine treatment and psychological evaluation, and the research group recieved cognitive behavioral intervention.The psychological status, quality of life, lung function and blood gas were compared between the two groups.Results The heart rate and respiratory rate in the research were slower than those of the control group, and the volume of forced exhalation in the first second was higher than that of the control group, the differences were statistically significant (P＜0.001).The blood oxygen saturation and arterial oxygen partial pressure in the research group were higher than those of the control group, and arterial carbon dioxide partial pressure in the research was lower than that of the control group, the differences were statistically significant (P＜0.001)；the generalized anxiety disorder scale (GAD) and Hamilton depression scale (HAMD)scores in the research group were lower than those in the control group, and the differences were statistically significant(P＜0.05).The quality of life score in the research group was higher than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion Cognitive behavioral intervention can improve the lung function and quality of life of COPD patients.
2020 Vol. 27 (11): 38-41 [Abstract] ( 87 ) HTML (37 KB)  PDF  (0 KB)  ( 8 )
42 Effect comparison of endoscopic titanium clip and drug injection in the treatment of acute non-variceal upper gastrointestinal bleeding
WANG Xue-qi； LIN Xing-di； ZHI Guan-guang； HUANG Xiao-qiao
Objective To compare the therapeutic effect of endoscopic titanium clip and drug injection in the treatment of acute non-varicose upper gastrointestinal bleeding (NVUGIB).Methods The clinical data of 100 patients with acute NVUGIB treated in Qingyuan Hospital of Traditional Chinese Medicine from January 2015 to March 2019 were retrospectively analyzed.They were divided into group A and group B according to different treatment methods, 57 cases in group A were treated with endoscopic titanium clip hemostasis and 43 cases in group B were treated with epinephrine injection.The hemostatic effect, surgical operation, blood transfusion volume, recovery rate and adverse reactions were compared between group A and group B.Results The immediate hemostasis rate and effective hemostasis rate of group A were higher than those of group B, the rebleeding rate and surgical operation rate after 72 hours were lower than those of group B, the blood transfusion volume was less than that of group B, and the recovery time of bowel sounds and hospitalization days were shorter than those of group B, with statistical differences (P＜0.05).There were no serious adverse reactions in group A and group B.Conclusion Compared with drug injection, the application of endoscopic titanium clip in the treatment of acute NVUGIB patients can improve the hemostasis effect, reduce the amount of surgical operation and blood transfusion, and accelerate the recovery rate.
2020 Vol. 27 (11): 42-44 [Abstract] ( 104 ) HTML (33 KB)  PDF  (0 KB)  ( 10 )
45 Application effect of psychological guidance intervention in patients with dual infection of acquired immune deficiency syndrome and tuberculosis
TAN Jian-ming
Objective To explore the application effect of psychological guidance intervention in patients with dual infection of acquired immune deficiency syndrome (AIDS) and tuberculosis.Methods A total of 60 patients with dual infection of AIDS and primary/re-treatment active tuberculosis who were admitted to Maoming Chronic Disease Control Center from August 2017 to August 2018 were selected as the research subjects.They were divided into control group and observation group according to the random number table method, 30 cases in each group.Patients in the control group were given routine nursing guidance intervention.In the observation group, psychological guidance intervention on the basis of the control group was added.The total treatment compliance the total, satisfaction, and quality of life before and after the intervention were compared between two groups.Results The total treatment compliance of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).AIDS quality of life scale (MOS-HIV) scores of the AIDS patients, After the intervention, the dimensions of the two groups were higher than before the intervention.The MOS-HIV scores from various dimensions of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05).The total satisfaction of nursing in the observation group was higher than that of the control group, and the difference was statistically significant(P＜0.05).Conclusion Psychological guidance intervention can effectively increase the treatment compliance of AIDS patients with tuberculosis, improve mental health and quality of life, and have positive practical significance and longterm social benefits.
2020 Vol. 27 (11): 45-47转51 [Abstract] ( 87 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
48 Effect of Propranolol combined with Octreotide on hemodynamics and hemostatic effect in patients with liver cirrhosis and upper gastrointestinal bleeding
LI Xiao-qing
Objective Upper gastrointestinal bleeding was a common complication in liver cirrhosis, and its treatment has always been a key clinical concern.In this study, Propranolol combined with Octreotide was used to explore its effect in patients with liver cirrhosis and upper gastrointestinal bleeding.Methods Sixty-six patients with liver cirrhosis accompanied with upper gastrointestinal bleeding who were treated in our hospital from March 2017 to June 2019 were selected as the research subjects.They were divided into control group (n=33) and observation group (n=33) according to the random number table method.In the control group, Octreotide was used, and in the observation group, Propranolol combined with Octreotide was applied.The indexes of left gastric vein, splenic vein，portal vein and hemostatic effect of the two groups were compared.Results The diameter of the left gastric vein and the shunt index in the observation group after treatment were lower than those in the control group, and the differences were statistically significant(P＜0.05).The diameter and blood flow of the splenic vein and portal vein in the observation group were lower than those in the control group, and the average speed was higher than that in the control group, with statistical differences(P＜0.05).The hemostatic time in the observation group was shorter than that in the control group, and the difference was statistically significant (P＜0.05).The re-bleeding rate two days after therapy in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The use of Propranolol combined with Octreotide in the treatment of upper gastrointestinal bleeding in liver cirrhosis can shorten the hemostatic time, reduce the re-bleeding rate after two days, and improve the indexes of the left gastric vein, splenic vein and portal vein of patients.
2020 Vol. 27 (11): 48-51 [Abstract] ( 78 ) HTML (33 KB)  PDF  (0 KB)  ( 14 )
52 Effect of super-small splint fixation in the treatment of senile osteoporotic distal radius fracture
SHAO Xiao-wu； LI lun； XU Jin-qiang
Objective To investigate the effect of super-wrist splinting in the treatment of elderly patients with osteoporotic distal radius fracture.Methods The clinical data of 105 elderly patients with osteoporotic distal radius fractures admitted to our hospital from May 2016 to May 2018 were retrospectively analyzed.According to different treatment methods, they were divided into super-wrist splint fixation group (n=54) and the cast group (n=51), the two groups of patients were followed up for 3 months after treatment, the wrist function and bone density of the two patients were compared.Results The improved Mcbridge wrist scores and Sannento imaging scores were 74.1% and 87.0% in the super-cleft splint-fixed group, both were higher than the plaster-fixed group of 51.0% and 72.5%, and the differences were statistically significant (P＜0.05).After 3 months of follow-up, the X-ray plain film data of the small splint group and the gypsum group were compared.The difference of the palm tilt angle, the ulnar angle and the ulnar and radial bone spacing of the small splint group were larger than that of the gypsum group, and the differences were statistically significant (P＜0.05).The changes of bone mineral density before treatment and after 3 months of treatment were compared.The change of bone mineral density in the super-wrist splint fixation group was smaller than that in the plasterfixed group, and the difference was statistically significant (P＜0.05).Conclusion The clinical effect of super-small splint fixation in the treatment of osteoporotic distal radius fractures in elderly patients is superior to the external fixation of gypsum, and should be promoted and applied in the clinical of brittle fractures of the distal radius.
2020 Vol. 27 (11): 52-55 [Abstract] ( 88 ) HTML (39 KB)  PDF  (0 KB)  ( 12 )
56 Application value of intravenous iron and oral iron in the clinical treatment of hemodialysis anemia
YE Shui-lian; HUANG Yong-hong
Objective To explore the application value of intravenous iron and oral iron in the clinical treatment of hemodialysis (HD) anemia.Methods A total of 125 patients with HD anemia admitted to our hospital from January 2018 to May 2019 were selected as the study objects.They were divided into vein group (n=62) and oral group (n=63)according to the random number table method.The oral group was treated with Polysaccharide Iron Complex Capsules,the vein group was treated with Sucrose Iron injection.The levels of hemoglobin (Hb), serum ferritin (SF) before and after treatment were compared between the two groups.Results After treatment, the levels of Hb and SF in venous group were higher than those in oral group, the differences were statistically significant (P＜0.05).The total effective rate of vein group was 95.16%, which was higher than that of oral group (80.95%), the difference was statistically significant (P＜0.05).The incidence of complications in vein group was 4.84%, which was lower than that in control group(17.46%), the difference was statistically significant (P＜0.05).Conclusion In the treatment of HD anemia related patients, intravenous iron treatment can effectively improve the level of Hb and SF in the course of treatment, improve the clinical treatment effect of patients, reduce the incidence of complications, and the effect is ideal.
2020 Vol. 27 (11): 56-58 [Abstract] ( 91 ) HTML (29 KB)  PDF  (0 KB)  ( 6 )
59 Effect of Bifidobacterium Tetrad combined with Mesalazine in the treatment of ulcerative colitis
HOU Jing; ZHU Mei-ling; LI Yun-hong
Objective To investigate the effect of Bifidobacterium Quadruple Live Tablets combined with Mesalazine on serum C-reactive protein (CRP) levels and adverse reactions in patients with ulcerative colitis (UC).Methods Eightysix patients with UC admitted to our hospital from January 2016 to September 2019 were enrolled in the study.They were divided into control group and observation group according to the random number table method, 43 cases in each group.The control group was treated with Mesalazine Enteric-Coated Tablets orally；the observation group was treated with Mesalazine Enteric-Coated Tablets and Bifidobacterium Quadruple Live Tablets；the patients in both groups were given continuous medication for 2 months.The treatment efficiency, c-reactive protein (CRP), interleukin-4 (IL-4), interleukin-8 (IL-8) index, disease activity index (Mayo) score, and adverse reactions were compared between the two groups.Results After 2 months of treatment, the effective rate of treatment in the observation group (95.35%) was higher than that in the control group (79.07%), and IL-4 (1.38±0.28) ng/ml was higher than that the control group for(0.94±0.31) ng/ml, CRP (7.85±2.74) mg/L, IL-8 index (17.64±4.59) μg/L, were lower than those of the control group(13.68±3.62) mg/L, (25.54±5.87) μg/L, Mayo score (3.42±0.44), and adverse reaction rate (6.98%) were lower than that in the control group for (5.84±0.38), the tatal of incidence of aduorse reactions (6.98%) was lower than that of the control group (25.58%), the differences were statistically significant (P＜0.05).Conclusion Bifidobacterium Quadruple Live Tablets combined with Mesalazine can effectively treat UC.It has synergistic therapeutic effect, can improve the treatment efficiency, regulate the levels of CRP, IL-4 and IL-8, and improve the immune function of the body, reducing the occurrence of adverse reactions, high safety, and huge prospects for clinical application, it is worth promoting.
2020 Vol. 27 (11): 59-62 [Abstract] ( 150 ) HTML (37 KB)  PDF  (0 KB)  ( 14 )
63 Clinical effect of Alogliptin in the treatment of type 2 diabetes mellitus complicated with coronary heart disease
ZHU Chang-dong; ZENG Xiao-bing; XIE Bao-qiang; XIE Fei-fei ; ZHOU Liang
Objective To study the clinical effect of Alogliptin in the treatment of patients with type 2 diabetes mellitus complicated with coronary heart disease.Methods A total of 80 patients with type 2 diabetes mellitus complicated with coronary heart disease from January 2017 to November 2018 in Department of Endocrinology and Geriatrics of Ganzhou Municipal Hospital were selected as the study subjects, and divided into two groups by computer random method,40 cases in each group.The patients in the observation group were treated with Alogliptin, while those in the control group were treated with routine therapy.The treatment effect, adverse reactions, blood glucose levels before and after treatment, number of angina attacks per week and duration of each angina attack were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group, with statistically significant differences (P＜0.05).After treatment, the levels of fasting blood glucose (FPG), postprandial blood glucose (2 h PG) and glycosylated hemoglobin (HbA1c) in the observation group were lower than those in the control group, with statistically significant differences (P＜0.05).After treatment, the number of angina attacks in the observation group was less than that in the control group, and the duration of each angina attack was shorter than that in the control group, with statistically significant differences (P＜0.05).Conclusion Alogliptin has a good curative effect on patients with type 2 diabetes complicated with coronary heart disease, which can stabilize blood glucose level and guarantee drug safety.It is worth studying.
2020 Vol. 27 (11): 63-66 [Abstract] ( 81 ) HTML (35 KB)  PDF  (0 KB)  ( 13 )
67 Clinical effect of Liraglutide combined with Metformin in the treatment of type 2 diabetes
WANG Ming
Objective To investigate the clinical effect of Liraglutide combined with Metformin in the treatment of type 2 diabetes.Methods A total of 80 patients with type 2 diabetes admitted to our hospital from January 2018 to January 2019 were selected as the study objects for retrospective analysis.According to different treatment methods, patients were divided into the control group (40 cases) and the study group (40 cases).The control group was treated with Metformin, while the study group was treated with Liraglutide combined with Metformin, and the blood glucose index, function index of islet β cells and treatment effect of patients were compared.Results After treatment, fasting blood glucose(FBG), 2 h postprandial blood glucose (2 h PG), glycosylated heamoglobin (HbA1c) in the study group were lower than those in the control group, with statistically significant differences (P＜0.05).Islet β cell function index (HOMA-β), insulin resistance index (HOMA-IR) were lower than those in the control group, and the total effective rate of treatment was higher than that in the control group, with statistically significant differences (P＜0.05).Conclusion The combination of Liraglutide and Metformin in the treatment of type 2 diabetes has positive clinical significance in improving the blood glucose level and the function index of islet β cells.
2020 Vol. 27 (11): 67-69 [Abstract] ( 116 ) HTML (33 KB)  PDF  (0 KB)  ( 12 )
70 Effect comparison of the of laparoscopic herniorrhaphy and open-type tension-free herniorrhaphy in the treatment of adult inguinal hernia
LIU Kai; ZUO Wu; WANG Bin; YANG Xiao-feng
objective To compare the clinical effect of laparoscopic herniorrhaphy and open-type tension-free herniorrhaphy in the treatment of adult inguinal hernia.Methods A total of 72 patients with inguinal hernia who were treated in our hospital from June 2017 to June 2018 were selected as the research subjects, they were divided into observation group and control group by random number table method, with 36 cases in each group.Laparoscopic herniorrhaphy was used in the observation group, and open-type tension-free herniorrhaphy was used in the control group.The general operative conditions, postoperative complications and postoperative follow-up of the two groups were compared.Results The operation time, postoperative pain duration, the time of out of bed and hospitalization days in the observation group were shorter than those in the control group, the amount of intraoperative bleeding and the times of painkiller use in the observation group were fewer than those in the control group, the differences were statistically significant (P＜0.05).The total incidence of postoperative complications in the observation group was 8.33%, which was lower than that in the control group (25.00%), the difference was statistically significant (P＜0.05).The time of disappearance of foreign body sensation in groin, induration of groin and numbness in the observation group were shorter than that in the control group, and the incidence of thrombosis and recurrence of hernia in femoral vein were lower than that in the control group, the differences were statistically significant (P＜0.05).Conclusion Laparoscopic herniorrhaphy is effective in the treatment of adult inguinal hernia, with fewer postoperative complications, which is worthy of clinical application.
2020 Vol. 27 (11): 70-72 [Abstract] ( 71 ) HTML (29 KB)  PDF  (0 KB)  ( 13 )
73 Clinical effect of automatic hemorrhoid ligation in the treatment of patients with hemorrhagic hemorrhoids
WANG Feng
Objective To investigate the clinical effect of automatic hemorrhoids ligation in the treatment of patients with hemorrhagic hemorrhoids.Methods Fifty patients with hemorrhagic hemorrhoids admitted to our hospital from May 2017 to January 2019 were selected as subjects.According to the patients′ consultation order, the serial number was assigned, and 50 patients were divided into observation group (25 cases) and control group (25 cases) by random sampling.The control group underwent traditional hemorrhoid ligation, and the observation group underwent automatic hemorrhoid ligation.The operation time, clinical efficacy and complications of the two groups were compared.Results The operation time and hospitalization time of the observation group were shorter than those of the control group, the treatment cost was higher than that of the control group, the total incidence of complications was lower than that of the control group, and the total effective rate of treatment was higher than that of the control group, with statistically significant differences (P＜0.05).Conclusion Compared with the traditional hemorrhoid ligation, the application effect of automatic hemorrhoid ligation on hemorrhagic hemorrhoid patients is better, the operation time is shorter, the incidence of complications is lower, and the treatment effect is obvious.Therefore, it is worthy of further research by medical workers and selection according to the actual situation
2020 Vol. 27 (11): 73-75 [Abstract] ( 85 ) HTML (32 KB)  PDF  (0 KB)  ( 13 )
76 Effect of Kang′ai Injection on liver function after colorectal cancer liver metastasis intervention
ZHANG Xiao-wei ; ZHOU Si-wei ; MA Zhen-nan▲
Objective To investigate the effect of Kang′ai Injection on liver function in patients with colorectal cancer liver metastasis after transcatheter arterial chemoembolization (TACE).Methods A total of 46 patients with colorectal cancer liver metastasis who were admitted to our hospital from January 2014 to December 2016 were selected as the research subjects.They were divided into control group and study group according to the order of admission, with 23 cases in each group.Both groups were treated with TACE, patients in the control group received regular liver protection therapy alone, while patients in the study group received Kang′ai Injection on the basis of regular liver protection therapy.The treatment effect, clinical main symptoms, serum liver function indicators (alanine transaminase [ALT], aspartate transaminase [AST], total bilirubin [TBil], total bile acid [TBA]and albumin [ALB]), tumor markers (carcinoembryonic antigen [CEA], carbohydrate antigen 19-9 [CA19-9]and alpha-fetoprotein [AFP]), and Karnofsky (KPS) scores before and after treatment in the two groups were compared.Results There were no significant differences in the incidence rates of pain in the liver area, fever and jaundice before treatment between the two groups of patients (P＞0.05).The incidence rates of pain in the liver area, fever and jaundice of the two groups after treatment were lower than those before treatment, and those in the study group were lower than those in the control group, the differences were statistically significant (P＜0.05).After treatment, the levels of ALT, AST, TBil, and TBA in the study group were lower than those in the control group, and the ALB level was higher than that in the control group, the differences were statistically significant (P＜0.05).There were no significant differences in the levels of tumor markers between the two groups after treatment (P＞0.05).The total effective rate of treatment in the study group (60.9%) was higher than that in the control group (52.2%), and the difference was statistically significant (P＜0.05).There was no significant difference in KPS score between the two groups after treatment (P＞0.05).Conclusion Kang′ai Injection has a better protection of liver function, can be used as an adjunct to prevent colorectal cancer liver metastasis after TACE from liver damage, and can also indirectly improve the overall therapeutic effect of colorectal cancer liver metastasis.
2020 Vol. 27 (11): 76-80 [Abstract] ( 83 ) HTML (40 KB)  PDF  (0 KB)  ( 13 )
81 Application effect of Paclitaxel combined with Cisplatin neoadjuvant chemotherapy in patients with locally advanced cervical cancer
MA Dong
Objective To explore the application effect of Paclitaxel combined with Cisplatin neoadjuvant chemotherapy in patients with locally advanced cervical cancer.Methods A total of 80 patients with locally advanced cervical cancer admitted to our hospital from September 2017 to July 2019 were selected as the study objects.According to the random number table method, the study objects were divided into control group and experimental group, 40 cases in each group.The control group was only treated by operation, and the experimental group was treated by Paclitaxel combined with Cisplatin neoadjuvant chemotherapy before operation.The clinical treatment effect, lymph node metastasis and incidence of adverse reactions were compared between the two groups of patients.Results The total remission rate of patients in the experimental group (75.00%) was higher than that in the control group (52.50%), and the difference was statistically significant (P＜0.05).The rates of parauterine lymph node metastasis and pelvic lymph node metastasis in the experimental group were 0.00% and 2.50%, which were lower than those in the control group (10.00% and 15.00%), and the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence rate of adverse reactions between the two groups (P＞0.05).Conclusion In the treatment of locally advanced cervical cancer, Paclitaxel combined with Cisplatin neoadjuvant chemotherapy before operation can improve the clinical treatment effect, inhibit lymph node metastasis, and the adverse reactions are slight, which is more conducive to the recovery of patients′ condition, and it is worth learning in clinical work.
2020 Vol. 27 (11): 81-83转87 [Abstract] ( 77 ) HTML (34 KB)  PDF  (0 KB)  ( 10 )
84 Clinical effect of radical transurethral resection of bladder tumor in the treatment of senile muscular invasive bladder cancer
ZHANG Wei; LU Yong ; GUO Gao-wei
Objective To explore the clinical effect of radical transurethral resection of bladder tumor in the treatment of senile muscular invasive bladder cancer.Methods Ninety patients with senile muscular invasive bladder cancer treated in our hospital from January 22, 2016 to January 22, 2019 were selected as the research subjects, and they were divided into control group (45 cases) and observation group (45 cases) according to the database odd and even random method.Patients in the control group were treated with partial bladder resection, and patients in the observation group were treated with radical transurethral resection of bladder tumor.The total incidence rate of complications, intraoperative blood loss, operation time, hospitalization time, resection margin negative rate, recurrence rates within 3 and 6 months, health-related quality of life (HRQOL) and function assesment of cancer therapy-bladder cancer form (FACTBL) scores before and after treatment were compared between the two groups.Results The total incidence rate of complications in the observation group (2.22%), the recurrence rate within 3 months (0.00%), and the recurrence rate within 6 months (2.22%) were lower than those in the control group (26.67%, 8.89%, 15.56%), and the differences were statistically significant (P＜0.05).The intraoperative blood loss of the observation group ([43.68±5.79]ml) was less than that of the control group ([56.19±7.18]ml), and the difference was statistically significant (P＜0.05).The operation time([23.41±2.33]min) and hospitalization time ([7.89±2.13]d) of the observation group were shorter than those of the control group ([38.96±5.46]min, [9.75±2.54]d), and the differences were statistically significant (P＜0.05).The resection margin negative rate of patients in the observation group (97.78%) was higher than that in the control group (73.33%),and the difference was statistically significant (P＜0.05).The HRQOL score ([56.79±6.22]points) and FACT-BL score([84.63±7.46]points)of the observation group were higher than those of the control group([42.38±4.54],[72.51±5.11]points),and the differences were statistically significant (P＜0.05).Conclusion The effect of radical transurethral resection of bladder tumor is significant in the treatment of senile patients with muscular invasive bladder cancer
2020 Vol. 27 (11): 84-87 [Abstract] ( 79 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
88 Application of "single operation hole" video-assisted thoracoscopic precise segmentectomy in patients with early-stage lung cancer
DING Yi-lin; ZHAO Qiang; ZHAO Xiao; HU De-hong
Objective To explore the application of "single operation hole" video-assisted thoracoscopic precise segmentectomy in patients with early-stage lung cancer.Methods From October 2018 to May 2019, 90 patients with early-stage lung cancer treated in our hospital were selected as the research objects, according to different surgical procedure,they were divided into control group(45 cases)and study group(45 cases).The control group was treated with"single operation hole" video-assisted thoracoscopic lobectomy, while the study group was treated with "single operation hole" video-assisted thoracoscopic precise segmentectomy.The surgical indexes, postoperative pain (visual analogue scale [VAS]), changes of lung function (forced vital capacity [FVC], forced expiratory volume in one second [FEV1]) before and after surgery, and incidence of postoperative complications were compared between the two groups.Results The operation time in the study group was longer than that in the control group, intraoperative blood loss, the volume of thoracic drainage on the first day after surgery, and total postoperative thoracic drainage volume in the study group were less than those in the control group, and postoperative drainage days, postoperative hospital stay in the study group were shorter than those in the control group, the differences were statistically significant (P＜0.05).There were no significant differences in VAS scores at the first, second, and third days after surgery between the two groups (P＞0.05).The FVC and FEV1 in the two groups after surgery in the two groups were lower than those before surgery, FVC and FEV1 in the study group after surgery were higher than those in the control group, and the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence rate of postoperative complications between the two groups (P＞0.05).Conclusion "Single operation hole" video-assisted thoracoscopic precise segmentectomy can reduce intraoperative blood loss, shorten hospital stay and better preserve the lung function of patients, which can be utilized as an option for those with early-stage lung cancer.
2020 Vol. 27 (11): 88-91 [Abstract] ( 81 ) HTML (45 KB)  PDF  (0 KB)  ( 10 )
92 Applied value analysis of thin-cytologic test and high-risk human papilloma virus examination for screening of cervical cancer
PAN Shao-xia ; SHU Qing
Objective To analyze the application value of thin-cytologic test (TCT) and high-risk human papilloma virus (HPV) examination for screening of cervical cancer.Methods A total of 260 cases of cervical cancer screening in our hospital from January 2018 to March 2019 were selected as the study subjects.All patients received TCT, HPV examination and pathological biopsy.The sensitivity, specificity and coincidence rate of TCT and HPV in single or combined disease examination were evaluated by pathological biopsy results as the gold standard of disease diagnosis.Results Pathological examination indicated 133 cases inflammation, 119 cases cervical intraepithelial neoplasia (CIN) and 8 cases cervical cancer.The diagnosis accordance rate, sensitivity and specificity based on HPV was 78.46%, 73.08%and 86.54%；the diagnosis accordance rate, sensitivity and specificity based on TCT was 85.38%, 83.09% and 87.90%；the diagnosis accordance rate, sensitivity and specificity based on combined examination was 96.92%, 96.85% and 96.99%.The diagnosis accordance rate, sensitivity and specificity of combined examination were higher than those of HPV or TCT, with statistically significant differences (P＜0.05).Conclusion For suspected cervical cancer patients, the combined examination of HPV and TCT has higher diagnosis accordance rate, sensitivity and specificity, providing references on clinical diagnosis.It is worthy of promotion.
2020 Vol. 27 (11): 92-94 [Abstract] ( 69 ) HTML (32 KB)  PDF  (0 KB)  ( 15 )
95 Clinical effect of Voriconazole+Itraconazole in the treatment of secondary fungal infections of hematological malignancies
JIANG Peng-fei; LIU Jia
Objective To analyze the difference of efficacy of Voriconazole+Itraconazole and Voriconazole alone in the treatment of patients with secondary fungal infections of hematological malignancies.Methods A total of 120 patients with secondary fungal infections of hematological malignancies treated in our hospital from June 2017 to June 2018 were selected as the research objects.According to the sequence of admission, the patients were divided into observation group and reference group, with 60 cases in each group.Patients in the observation group were treated with Voriconazole+Itraconazole, and patients in the reference group were treated with Voriconazole alone.The therapeutic effect, the incidence of adverse reactions, the levels of inflammatory factors (tumor necrosis factor α [TNF-α], interleukin-4 [IL-4], interleukin-10 [IL-10], interleukin-12 [IL-12]) before and after treatment, improvement time of clinical symptoms (fever, cough, sputum, nausea, septic shock, and respiratory failure) were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Before treatment, there were no statistically significant differences in the contents of TNF-α, IL-12, IL-4 and IL-10 between the two groups (P＜0.05).After treatment, the levels of TNF-α, IL-12 in both groups were lower than those before treatment, and the levels of IL-4 and IL-10 were higher than those before treatment, with statistical differences (P＜0.05).After treatment, the levels of TNF-α and IL-12 in the observation group were lower than those in the control group, and the levels of IL-4 and IL-10 were higher than those in the control group, with statistical differences (P＜0.05).The improvement time of fever, cough, sputum, nausea, septic shock, and respiratory failure in the observation group was shorter than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The application of Voriconazole+Itraconazole in the treatment of patients with secondary fungal infections of hematological malignancies has definite clinical effects, and it can improve the clinical symptoms and inflammatory factor levels of patients as soon as possible, which is suitable for clinical application and promotion.
2020 Vol. 27 (11): 95-98 [Abstract] ( 86 ) HTML (34 KB)  PDF  (0 KB)  ( 8 )
99 Application of integrated physical and mental nursing intervention in full-term delivery women
CHEN Xing-hong; SHI Li; CHEN Xiu-fan
Objective To explore the application of integrated physical and mental nursing intervention in full-term delivery women.Methods A total of 156 women who underwent full-term delivery in our hospital from November 2017 to October 2018 were selected as the research subjects.By the random number table method, they were divided into the control group (n=78) and the observation group (n=78).In the control group, routine nursing was used, and in the observation group, on the basis of the control group, integrated physical and mental nursing was added.To evaluate the nursing effect of the two groups，the first lactation time and amount of lactation, serum prolactin (PRL) index, breastfeeding rate, role transition and postpartum depression were compared between the two groups.Results The amount of lactation and PRL level 48 hours after delivery were higher than those 24 hours after labor, the differences were statistically significant (P＜0.05).The first lactation time of the observation group was shorter than that of the control group,the amount of lactation and PRL level 48 hours after delivery of the observation group were higher than those of the control group （P＜0.05）, the maternal breastfeeding rate and infant care scores of the observation group after intervention were higher than those of the control group, the differences were statistically significant (P＜0.05).The incidence of maternal negative emotions of the observation group after intervention was lower than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion The application of integrated physical and mental nursing intervention in the full-term delivery women has significant effects.It is beneficial for milk secretion, completion of the role transition as soon as possible, increase of the breastfeeding rate, and reduction of maternal depression.It is worth clinical applying.
2020 Vol. 27 (11): 99-101 [Abstract] ( 60 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
102 Effect of painless delivery combined with free position for labor on the self-efficacy and delivery outcomes of primiparas
HUANG Jing-yun; ZHANG Chun-xiu; ZHANG Li-ming; HONG Jing-dan
Objective To analyze the effect of painless delivery combined with free position for labor on the self-efficacy and delivery outcomes of primiparas.Methods A total of 200 primiparas admitted to our hospital from July 2018 to April 2019 were selected as research objects.They were divided into the control group (100 cases) and the experimental group (100 cases) according to the simple random sampling method.The control group used the natural conventional method for labor, and the experimental group used the painless labor combined with free position method for labor.The cesarean section rate, visual analogue scale (VAS) score, total postpartum hemorrhage, length of hospital stay,labor process, and neonatal Apgar score between the two groups were compared.The pelvic floor muscle strength, muscle fatigue after delivery, delivery outcomes, and self-efficacy scores before and after delivery in the two groups were observed.Results The cesarean section rate in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05).The VAS score of the experimental group was lower than that of the control group, the total postpartum hemorrhage was less than that of the control group, and the length of hospital stay was shorter than that of the control group, the differences were statistically significant (P＜0.05).The first, second, and third stages of labor process in the experimental group were shorter than those in the control group, and the differences were statistically significant (P＜0.05).Apgar score at 1 minute of birth in the experimental group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Before delivery, there were no significant differences in the self-efficacy scores between the two groups (P＞0.05).After delivery, the self-efficacy scores of the two groups were higher than those before delivery, and the differences were statistically significant (P＜0.05).After delivery, the positive attitude, self-determination, and self-decompression scores in the experimental group were higher than those in the control group, and the differences were statistically significant (P＜0.05).The pelvic floor muscle strength after delivery in the experimental group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The muscle fatigue of Ⅰand Ⅱfibers in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05).The total incidence rate of adverse delivery outcomes in the experimental group (19.0%) was lower than that in the control group (37.0%), and the difference was statistically significant (P＜0.05).Conclusion Painless delivery combined with free position for labor in primiparas is helpful to protect the pelvic floor function, shorten the labor process, improve the self-efficacy to a certain extent,which is beneficial to postpartum psychological and physiological recovery.
2020 Vol. 27 (11): 102-106 [Abstract] ( 67 ) HTML (44 KB)  PDF  (0 KB)  ( 8 )
107 Clinical value of transvaginal ultrasound monitoring cervical length in predicting twin preterm birth
ZENG Zhao-shan; ZENG Rui-hua; LIANG Bai-yun; HUANG Ping; XU Xiu-lan; LIANG Jin-jin
Objective To observe the effect of transvaginal ultrasound monitoring cervical length in predicting twin preterm birth.Methods A total of 272 cases of pregnant women with threatened preterm births from June 2018 to Jauary 2019 were randomly selected.They were divided into transvaginal ultrasound group (n=136) and transabdominal ultrasound group (n=136) according to the random number table method.Pregnant women in transvaginal ultrasound group were monitored by transvaginal ultrasound, and pregnant women in transabdominal ultrasound group were monitored by transabdominal ultrasound.Then the premature delivery rates of different cervical length in two groups of pregnant women and the values of predicting preterm births of twins were statistically analyzed.Results The premature delivery rate of pregnant women with cervical length ＜2.6 cm of the transvaginal ultrasound group was higher than that of transabdominal ultrasound group, the difference was statistically significant (P＜0.05), the premature delivery rate of the pregnant women with cervical length ≥2.6 cm was lower than that of transabdominal ultrasound group, the difference was statistically significant (P＜0.05).The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of transvaginal ultrasound group were higher than those of the transabdominal ultrasound group, the differences were statistically significant (P＜0.05).Conclusion The effect of transvaginal ultrasound monitoring cervical length is better than that of transabdominal ultrasound in predicting preterm births.
2020 Vol. 27 (11): 107-109 [Abstract] ( 59 ) HTML (31 KB)  PDF  (0 KB)  ( 9 )
110 Clinical effect of Lactobacillus Vagina Capsules combined with Estradiol Valerate in the treatment of senile vaginitis
XU Shu-hua
Objective To investigate the clinical effect of Lactobacillus Vagina Capsules combined with Estradiol Valerate in the treatment of senile vaginitis.Methods from January 2017 to January 2019, 62 cases of senile vaginitis patients were selected as the research subjects, according to the number of blind choice method, they were divided into control group (31 cases) and observation group (31 cases).The control group was treated with Estradiol Valerate, the observation group was treated with Lactobacillus Vagina Capsules combined with Estradiol Valerate, the estrogen levels, vaginal pH change, total effective rate of treatment, the total rate of relapse were compared between the two groups.Results There were no significant differences in serum estradiol (E2), progesterone (P), follicle-forming hormone (FSH),luteinizing hormone (LH) between the two groups (P＞0.05).The vaginal pH value of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05).The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant(P＜0.05).The total recurrence rate of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion The application of Lactobacillus Vagina Capsules combined with Estradiol Valerate in senile vaginitis patients can reduce the vaginal pH value of the patients, improve the total effective rate of treatment, reduce the recurrence rate, and have little effect on the estrogen level of the patients.
2020 Vol. 27 (11): 110-112 [Abstract] ( 69 ) HTML (33 KB)  PDF  (0 KB)  ( 12 )
113 Application effect of modified tubularized incised plate urethroplasty in children with hypospadias Ⅱ
ZHAO Zhang； LIU Guo-chang； FU Wen； ZHANG Li-yu； HU Jin-hua
Objective To investigate the application effect of modified tubularized incised plate urethroplasty (modified Snodgrass surgery) in children with hypospadias Ⅱ.Methods A retrospective analysis of 120 children with hypospadiasⅡtreated in our hospital from July 2016 to July 2019 was conducted.According to different surgical schemes, they were divided into the experimental group(n=60)and control group(n=60).The experimental group was treated with modified Snodgrass surgery and the control group was treated with urethral basal vascular flap urethroplasty(Mathieu surgery).The clinical efficacy of the two groups was observed and compared.Results The operation time and the time of getting out of bed in the experimental group were shorter than those of the control group, and the bleeding volume was less than that of the control group with statistical significance (P＜0.05).There was no significant difference in the surgical success rate between the two groups (P＞0.05).The postoperative visual analogue scale (VAS) pain score in the experimental group was lower than that in the control group with statistical significance (P＜0.05).There was no significant difference in the total incidence of complications between the two groups (P＞0.05).Conclusion The modified Snodgrass surgery has significant clinical effect in treating children with hypospadias Ⅱ, which can effectively reduce the pain symptoms of children.The surgical success rate and safety are higher, which is beneficial for children′s recovery.
2020 Vol. 27 (11): 113-115转119 [Abstract] ( 58 ) HTML (34 KB)  PDF  (0 KB)  ( 9 )
116 Application effect of uterine artery embolization in cesarean scar pregnancy patients
ZHANG Wen-li； ZHANG Zhong-ming； FENG Cai-xia； WANG Rui
Objective To investigate the application effect of uterine artery embolization cesarean scar pregnancy patients.Methods The general clinical data of cesarean scar pregnancy patients trested in the First Affiliated Hospital of Xi'an Jiaotong University from January 2014 to December 2017 were retrospectively analyzed.Patients were divided into interventional embolization group (31 cases) and laparoscopy group (35 cases) according to different treatment methods.Patients in the interventional embolization group were treated with uterine artery embolization and hysteroscopic hysterectomy, while patients in the hysteroscopy group were treated with hysteroscopy combined with laparoscopic resection and repair of scar pregnancy lesions.Treatment and prognostic parameters were compared between the two groups.Results The intraoperative blood loss in the interventional embolization group was less than that in the laparoscopic group, and the length of stay was shorter than that in the laparoscopic group, with statistically significant differences (P＜0.05).There were no significant differences in the operation time and treatment success rate between the two groups (P＞0.05).The time of vaginal bleeding and serum human chorionic gonadotropin (β-HCG) in the interventional embolization group after treatment was shorter than that in the laparoscopy group, with statistically significant difference (P＜0.05).There was no significant difference in the menstrual status between the two groups after treatment (P＞0.05).Conclusion The efficacy of uterine artery embolization in the treatment of scar pregnancy is confirmed.Compared with the combined approach of laparoscopy, the duration of hospital stay is shorter, the time of postoperative vaginal bleeding and the time for serum β-HCG to return to normal is also shorter
2020 Vol. 27 (11): 116-119 [Abstract] ( 46 ) HTML (36 KB)  PDF  (0 KB)  ( 9 )
120 Clinical effect of Levofloxacin Eye Drops combined with Ganciclovir Eye Drops in children with conjunctivitis
WEN Jiang-jiang
Objective To investigate the clinical effect of Levofloxacin Eye Drops combined with Ganciclovir Eye Drops in the treatment of children with conjunctivitis.Methods Forty children with conjunctivitis admitted to our hospital from February 2018 to February 2019 were selected as subjects in the study.They were divided into control group(20 cases) and observation group (20 cases) according to the lottery method.The control group was treated with Levofloxacin Eye Drops, and the observation group was treated with Levofloxacin Eye Drops combined with Ganciclovir Eye Drops.The clinical symptom scores, clinical efficacy and total incidence of adverse reactions were compared between the two groups.Results After treatment, the scores of clinical symptoms such as conjunctival congestion, pain,photophobia, foreign body sensation, tears and eye secretions in the observation group were all lower than those in the control group, with statistically significant differences (P＜0.05).The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion Levofloxacin Eye Drops combined with Ganciclovir Eye Drops in the treatment of children with conjunctivitis is ideal, which can significantly improve the patients′ symptoms and reduce the incidence of adverse reactions, and has a high clinical value.
2020 Vol. 27 (11): 120-122 [Abstract] ( 82 ) HTML (32 KB)  PDF  (0 KB)  ( 11 )
123 Effect of new model of postnatal visit service management on maternal and newborn family visits
LUO Si-min
Objective To explore the effect of the new model of postnatal visit service management in maternal and neonatal family visits.Methods A total of 400 pregnant women and their newborns who delivered in our hospital from January 2017 to December 2018 were selected as subjects.According to the principle of computer randomization, they were divided into observation group (195 cases) and control group (205 cases).A new mode of family visits for postpartum visit service management was implemented in the observation group, and regular visits were conducted in the control group.The abnormalities of maternal and neonatal conditions and the satisfaction of maternal satisfaction with the visit service were compared.Results The total incidence of abnormalities in maternal and neonatal cases was lower in the observation group than in the control group, the satisfaction score of the observation group was higher than that of the control group, the differences were statistically significant (P＜0.05).Conclusion The application of a new model of postpartum visit service management in maternal and neonatal family visits can effectively improve the visit effectiveness and benefit maternal and child health.
2020 Vol. 27 (11): 123-125转129 [Abstract] ( 61 ) HTML (34 KB)  PDF  (0 KB)  ( 11 )
126 Application of hormone replacement therapy in patients with perimenopausal syndrome
DENG Xin； REN Ran
Objective To explore the application value of hormone replacement therapy in patients with perimenopausal syndrome.Methods A total of 80 women with perimenopausal syndrome admitted in our hospital from November 2017 to January 2019 were selected as subjects.According to the random number table method, they were divided into observation group (40 cases) and control group (40 cases).Patients in the control group were given symptomatic support treatment, orally administered with Guweisu Tablets and Kuntai Capsules.Patients in the observation group were treated with Estradiol Valerate Tablets combination with Medroxyprogesterone Acetate Dispersive Tablets.Patients in both groups were treated continuously for 6 courses of treatment, as one treatment cycle.After 1 cycle of treatment, all participants were followed up in the outpatient department for 3 months.The scores of female sexual life quality standard indicator scale (FSFI) at 3 months after intervention were compared between the two groups.Changes in levels of sex hormones, such as estradiol (E2), follicle-stimulating hormone (FSH) and luteinizing hormone (LH), at 3 months after intervention were compared between the two groups.The incidence of clinical symptoms such as irritability, fatigue, insomnia, abnormal sex life and hot flashes during the follow-up of the two groups were calculated.The changes of total cholesterol levels before and after intervention were compared between the two groups.Results Three months after intervention, FSFI scores and total score of the observation group were higher than those of the control group, with statistically significant differences (P＜0.05).Three months after intervention, the E2 level of the observation group was higher than that of the control group, and the LH and FSH levels were lower than those of the control group, with statistically significant differences (P＜0.05).During the follow-up, the incidences of clinical symptoms such as irritability, fatigue,insomnia, abnormal sex life and hot flashes in the observation group were all lower than those in the control group, with statistically significant differences (P＜0.05).At 1 and 3 months after intervention, the total cholesterol level of the two groups was lower than that before the intervention, and the total cholesterol level of the observation group was lower than that of the control group, with statistically significant differences (P＜0.05).Conclusion For perimenopausal syndrome, the combination of Estradiol Valerate Tablets with Medroxyprogesterone Acetate Dispersive Tablets can effectively improve the quality of patients' sex life, regulate the level of sex hormones, improve clinical symptoms, and reduce the level of blood lipid.
2020 Vol. 27 (11): 126-129 [Abstract] ( 67 ) HTML (39 KB)  PDF  (0 KB)  ( 10 )
130 Application of comfortable nursing in children with upper respiratory tract infection
CHEN Hui-na； WANG Yin-ge
Objective To explore the application of comfortable nursing in children with upper respiratory tract infection.Methods A total of 200 children with upper respiratory tract infection who were admitted to our hospital from June 2017 to August 2018 were selected as study subjects.They were divided into observation group (n=100) and control group (n=100) according to the computer random method.The observation group used comfortable nursing and the control group used routinenursing.The comfort score and hospitalization time, complication rate, and family satisfaction were compared between the two groups.Results The environmental comfort, physiological comfort and psychological comfort scores of the observation group were higher than those of the control group, and the hospitalization time was shorter than that of the control group, the differences were statistically significant (P＜0.05).The total incidence of complications in the observation group was 3.00%, lower than that in the control group of 26.00%, the difference was statistically significant (P＜0.05).The total satisfaction of the observation group was 98.00%, which was higher than that of the control group (80.00%), the difference was statistically significant (P＜0.05).Conclusion Comfort nursing has high application value in children with upper respiratory tract infection, which can not only improve the comfort of children,but also shorten the length of hospital stay, reduce the risk of complications and improve the satisfaction of family members.It is worthy of research and promotion.
2020 Vol. 27 (11): 130-132 [Abstract] ( 69 ) HTML (31 KB)  PDF  (0 KB)  ( 13 )
133 Application of targeted nursing in pediatric pneumonia
WANG Pei-fen； LI Fei-yan； YAN Qin； YAN Yan-yan3； WANG Chun-yan
Objective To explore the application of targeted nursing in pediatric pneumonia.Methods A total of 80 cases of pediatric pneumonia patients admitted to our hospital from January to December 2018 were selected as the research objects.According to the random number table method, they were divided into the reference group (n=40) and the targeted group (n=40).Routine nursing method was adopted in the reference group and targeted nursing intervention method was adopted in the targeted group.The nursing effect, symptom disappearance time and nursing satisfaction of family members were compared between the two groups.Results The time of symptom disappearance of each disease in the targeted group was shorter than that in the control group, and the difference was statistically significant (P＜0.05).The total effective rate of 95.00% in the targeted group, which was higher than that in the control group of 77.50% (P＜0.05).The total satisfaction of nursing for the families of children with in targeted group was 97.50%, which was higher than that in control group of 82.50%, and the difference was statistically significant (P＜0.05).Conclusion Targeted nursing for pediatric pneumonia patients can effectively shorten the disappearance time of disease symptoms, improve the nursing effect and nursing satisfaction of children′s families, with significant value.
2020 Vol. 27 (11): 133-135 [Abstract] ( 80 ) HTML (33 KB)  PDF  (0 KB)  ( 12 )
136 Clinical effect of Compound Camphorine Injection in the treatment of ocular fundus disease and its influence on hemodynamics
FENG Wei
Objective To explore the clinical effect of Compound Camphorine Injection in the treatment of ocular fundus disease and its influence on hemodynamics.Methods A total of 100 patients with ocular fundus disease treated in our hospital from December 2016 to November 2018 were selected as research objects.According to the random number table method, they were divided into observation group and control group, with 50 cases in each group.The control group received routine treatment, and the observation group was treated with Compound Camphorine Injection on the basis of the control group.The hemodynamic indexes before and after treatment, the total effective rate and visual acuity of the two groups were analyzed and compared.Results After treatment, the whole blood viscosity, plasma viscosity,fibrinogen, erythrocyte aggregation index and erythrocyte specific capacity of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).The visual acuity of the observation group after treatment was better than that of the control group, the difference was statistically significant (P＜0.05).The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion The clinical effect of Compound Camphorine Injection in the treatment of ocular fundus diseases is significant, which can effectively improve the hemodynamic indexes of patients and promote the recovery of vision.
2020 Vol. 27 (11): 136-138 [Abstract] ( 64 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
139 Clinical effect of basic treatment combined with periodontal maintenance in treatment of chronic periodontitis
MAI Zong-da
Objective To explore the clinical effect of basic treatment combined with periodontal maintenance in treatment of chronic periodontitis.Methods A total of 360 patients with chronic periodontitis who were treated in our hospital from September 2012 to November 2018 were selected as the subjects.According to the random number table method, the patients were divided into control group and observation group, with 180 cases in each group.The control group were given conventional basic treatment, while the observation group were given basic treatment combined with periodontal maintenance.The treatment effect, periodontal index, number of missing teeth per year, and recurrence rate of periodontitis before and after treatment were observed and compared.Results The total effective rate of the observation group (96.11%) was higher than that of the control group (81.67%), with statistical difference (P＜0.05).There were no significant differences in periodontal pocket probing depth (PD), bleeding index (BI), plaque index (PLI), and clinical attachment loss (CAL) between the two groups before treatment (P＞0.05).After treatment, the PD, BI, PLI and CAL of the two groups were lower than those before treatment, the differences were statistically significant (P＜0.05).After treatment, the PD, BI, PLI and CAL of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).The average number of missing teeth per year in the observation group was fewer than that in the control group, and the recurrence rate of periodontitis was lower than that in the control group, with statistical differences (P＜0.05).Conclusion In clinical treatment of patients with chronic periodontitis, basic treatment combined with periodontal maintenance can effectively improve the periodontal condition of patients, help to maintain the treatment effect, and reduce the recurrence rate.The effect is significant and worthy to be popularized in the clinical practice.
2020 Vol. 27 (11): 139-141转148 [Abstract] ( 71 ) HTML (34 KB)  PDF  (0 KB)  ( 12 )
142 Clinical application effect of epidural anesthesia in painless delivery
HUANG Yi-shan; WU Dong-peng; ZHANG Yan-xiang
Objective To investigate the clinical effect of epidural anesthesia in painless delivery.Methods Fifty primiparas from February 2018 to February 2019 in our hospital were selected as subjects.According to the method of computer random grouping, they were divided into control group (25 cases) and study group (25 cases).The control group underwent painless labor under intravenous anesthesia, and the study group underwent painless delivery under epidural anesthesia.The analgesic efficiency, natural delivery rate, uterine contraction interval, duration of contractions, neonatal asphyxia rate, and intrauterine distress rate were compared between the two groups.Results The analgesic efficiency and natural delivery rates of the study group were higher than those of the control group, the differences were statistically significant (P＜0.05)；there were no statistical differences in the interval between contractions, duration of contractions, neonatal asphyxia rate, intrauterine distress rate (P＞0.05).Conclusion Epidural anesthesia for painless delivery can effectively increase the analgesic efficiency and natural delivery rate, and will not increase the neonatal asphyxia rate, fetal intrauterine distress rate, the application value is extremely positive.
2020 Vol. 27 (11): 142-144 [Abstract] ( 58 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
145 Application value of ultrasound -guided continuous saphenous nerve catheterization block after knee arthroplasty
YANG Zong-lei
Objective To explore the application value of ultrasound-guided continuous saphenous nerve catheterization block after knee arthroplasty.Methods A total of 80 csaes with knee arthroplasty under spinal anesthesia from July 2017 to July 2019 treated in our hospital were selected.According to the random number table method,they were divided into control group and observation group, with 40 cases in each group.The control group received intravenous continuous patient-controlled analgesia, and the observation group received ultrasound-guided continuous saphenous nerve block analgesia.The pain score at different time points after operation, the time of getting out of bed after operation,the knee joint activity 48 h after operation, the hospitalization time after operation, and the incidence rate of nausea,vomiting, dizziness, urinary retention and lower limb muscle strength reduction were compared between the two groups.Results The pain scores in the observation group at 12, 24 and 48 h after operation were lower than those in the control group, the differences were statistically significant (P＜0.05).The ambulation time in the observation group after operation was earlier than that in the control group, the knee joint activity at 48 h after operation was greater than that in the control group, the hospitalization time after operation was shorter than that in the control group, the differences were statistically significant (P＜0.05).The total incidence of complications in the observation group at 48 h after operation were lower than control group, the difference was statistically significant (P＜0.05).Conclusion For patients undergoing knee arthroplasty, ultrasound-guided continuous saphenous nerve catheterization block analgesia can effectively reduce postoperative pain and promote early recovery of bed and joint function,with fewer complications and high safety.
2020 Vol. 27 (11): 145-148 [Abstract] ( 64 ) HTML (36 KB)  PDF  (0 KB)  ( 13 )
149 Effect of ultrasound-guided anterior serratus plane block on the degree of pain and prognosis after radical mastectomy for breast cancer
LI Zhi-xiong
Objective To investigate the effect of ultrasound-guided anterior serratus plane block on the degree of pain and prognosis after radical mastectomy for breast cancer.Methods A total of 50 undergoing radical mastectomy for breast cancer treated in our hospital from July 2016 to December 2018 were selected as the research subjects.The patients were divided into observation group(n=25)and control group(n=25)according to the random number table method.Patients in the observation group underwent ultrasound-guided anterior serratus plane block, and patients in the control group underwent routine anesthesia.The postoperative pain (numerical rating scale [NRS]), oxidative stress molecules(superoxide dismutase [SOD], malondialdehyde [MDA], myeloperoxidase [MPO]), and inflammatory factors (nuclear factor-кB [NF-кB], interleukin-18 [IL-18], tumor necrosis factor-α[TNF-α]) levels before and after surgery were compared in two groups of patients.Results The NRS scores of patients in the observation group at 4, 8 and 24 hours after surgery were lower than those in the control group, and the differences were statistically significant (P＜0.05).There were no significant differences in the levels of SOD, MDA and MPO before surgery between the two groups of patients(P＞0.05).The SOD levels of the two groups of patients after surgery were lower than those before surgery, and the levels of MDA and MPO were higher than those before surgery, the differences were statistically significant (P＜0.05).The SOD level after surgery in the observation group was higher than that in the control group, and the levels of MDA and MPO were lower than those in the control group, the differences were statistically significant (P＜0.05).There were no significant differences in the levels of IL-18, TNF-α, NF-кB before surgery between the two groups of patients (P＞0.05).The levels of IL-18, TNF-α, and NF-кB in the two groups after surgery were higher than those before surgery,and the differences were statistically significant (P＜0.05).The levels of IL-18, TNF-α, and NF-кB in the observation group after surgery were lower than those in the control group, and the differences were statistically significant(P＜0.05).Conclusion Ultrasound-guided anterior serratus plane block in the implementation of radical mastectomy for breast cancer can effectively relieve postoperative pain, reduce oxidative stress and reduce suffering of patients, which is of great significance for improving prognosis.
2020 Vol. 27 (11): 149-152 [Abstract] ( 66 ) HTML (36 KB)  PDF  (0 KB)  ( 9 )
153 Role analysis of low dose Dexmetomide in the awakening period of Sevoflurane general anesthesia in children with sleep apnea syndrome surgery
REN Qiao
Objective To investigate the role of low dose Dexmetomide in the awakening period of Sevoflurane general anesthesia in children with sleep apnea syndrome surgery.Methods A total of 66 children with sleep apnea syndrome who underwent surgical treatment in our hospital from November 2017 to November 2018 were selected as the research subjects.All children were treated with tonsil adenoidectomy under Sevoflurane inhalation general anesthesia.They were divided into observation group and reference group according to the random number table method, with 33 cases in each group.Children in the reference group were intravenously injected with Ringer′s solution before induction of anesthesia, and children in the observation group were given low dose Dexmedetomidine.The changes of heart rate(HR) and mean arterial pressure (MAP) of the two groups in different periods of anesthesia were compared.The Ramsay sedation score and pediatric anesthesia emergence delirium scale (PAED) score were evaluated, and the incidence of restlessness, the duration of restlessness and the awakening time of anesthesia were recorded in both groups.Results The HR and MAP in the observation group at 10 minutes after injection (T2), awake extubation (T3), and 5 minutes after extubation (T4) were lower than those in the reference group, and the differences were statistically significant (P＜0.05).The PAED score and the incidence rate of restlessness in the observation group were lower than those in the reference group, the Ramsay sedation score was higher than that in the reference group, and the duration of restlessness was shorter than that in the reference group, the differences were statistically significant (P＜0.05).There was no significant difference in the awakening time of anesthesia between the two groups of children (P＞0.05).Conclusion The application of low dose Dexmetomide in children with sleep apnea syndrome during Sevoflurane general anesthesia can maintain better sedation effect, maintain hemodynamic stability, reduce the incidence rate of restlessness during recovery,and has the value of clinical promotion.
2020 Vol. 27 (11): 153-155转159 [Abstract] ( 58 ) HTML (37 KB)  PDF  (0 KB)  ( 14 )
156 Clinical effect of general anesthesia combined with epidural anesthesia in laparoscopic surgery for elderly rectal cancer
LI Hui
Objective To explore the application effect of general anesthesia combined with epidural anesthesia in laparoscopic surgery for elderly rectal cancer.Methods The clinical data of 108 elderly patients with rectal cancer treated in our hospital from February 2017 to June 2019 were analyzed retrospectively.According to different treatment methods, the patients were divided into control group (54 cases) and study group (54 cases).Patients in the control group received general anesthesia, and in the study group, the patients received general anesthesia combined with epidural anesthesia.The anesthetic effect, heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure(DBP) were compared between the two groups.Results There were no significant differences in HR, SBP and DBP before anesthesia between the two groups (P＞0.05).The HR and SBP during intubation and extubation in the study group were lower than those in the control group, the differences were statistically significant (P＜0.05).There were no significant differences in HR and SBP between the two groups (P＞0.05).The SBP and DBP of the two groups 20 minutes after pneumoperitoneum were higher than those before anesthesia, the differences were statistically significant (P＜0.05).There were no significant differences in SBP and DBP between the two groups 20 min after deflation (P＞0.05).The SBP and DBP of 20 min after pneumoperitoneum in the study group were lower than those in the control group, the differences were statistically significant (P＜0.05).Conclusion General anesthesia combined with epidural anesthesia has a good clinical effect and high safety during radical surgery for rectal cancer.It is worthy of promotion and application in clinic.
2020 Vol. 27 (11): 156-159 [Abstract] ( 67 ) HTML (33 KB)  PDF  (0 KB)  ( 10 )
160 Effect of Chinese medicine cycle therapy on traditional Chinese medicine syndrome and degree of intrauterine adhesion in patients with mild and moderate intrauterine adhesion
WU Lv
Objective To investigate the effect of Chinese medicine cycle therapy on traditional Chinese medicine(TCM) syndrome and degree of intrauterine adhesion in patients with mild and moderate intrauterine adhesion.Methods A total of 100 patients with mild and moderate intrauterine adhesion admitted to our hospital from March 2017 to March 2019 were enrolled in the study.The patients were divided into the control group (50 cases) and the observation group (50 cases) according to the random number table method.Patients in the control group were treated with Western medicine, and patients in the observation group were combined with Chinese medicine cycle therapy on that basis.Both groups were treated for 3 menstrual cycles.The clinical efficacy, TCM syndrome and degree of intrauterine adhesion scores before and after treatment were compared between the two groups of patients.Results The total effective rate of treatment in the observation group (94.00%) was higher than that in the control group (80.00%), and the difference was statistically significant (P＜0.05).After treatment, the TCM syndrome scores in the two groups of patients were lower than those before treatment, and the TCM syndrome score in the observation group ([12.54±4.23]points) was lower than that in the control group ([23.67±6.95]points), with statistically significant differences (P＜0.05).After treatment, the degree of intrauterine adhesion scores in the two groups of patients were lower than those before treatment, and the degree of intrauterine adhesion score in the observation group ([1.46±0.62]points) was lower than that in the control group ([2.23±0.93]points), with statistically significant differences (P＜0.05).Conclusion The use of Chinese medicine cycle therapy for patients with mild and moderate intrauterine adhesion can improve the symptoms and promote the uterine cavity recovery of patients.The curative effect is higher than that of Western medicine.
2020 Vol. 27 (11): 160-162转166 [Abstract] ( 57 ) HTML (35 KB)  PDF  (0 KB)  ( 9 )
163 Application of Jiyu Decoction in bone graft fusion after removal of nucleus pulposus in lumbar disc herniation
LI Xin
Objective To explore the clinical application value of Jiyu Decoction in bone graft fusion after removal of nucleus pulposus in lumbar disc herniation.Methods A total of 80 patients with lumbar disc herniation treated in our hospital from January 2018 to March 2019 were selected as the research subjects.They were divided into observation group (40 cases) and control group (40 cases) according to the random number table method.In the control group, internal fixation of bone graft fusion and removal of nucleus pulposus was used, while in the observation group, Jiyu Decoction was added on the basis of the control group.They were followed up for 6 months.The American Spinal Injury Association (ASIA) scores of the lower limbs of the two groups were compared and the quality of life (QOL) scores before and after treatment were recorded.The bone mineral density, bone calcitonin, and bone graft fusion of the two groups were observed.Results After 6 months of treatment, the motor and sensory function scores of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05).After treatment,the QOL scores of the two groups were higher than those before the treatment, and the QOL score of the observation group was higher than that of the control group, the differences were statistically significant (P＜0.05).After 6 months of treatment, the bone mineral density and bone calcitonin level in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05).The proportions of bone graft fusion in the observation group were higher than those in the control group at 1 and 6 months after operation, and the differences were statistically significant (P＜0.05).Conclusion For the bone graft fusion and removal of nucleus pulposus in lumbar disc herniation, combined with Jiyu Decoction after operation, it can effectively improve the functional recovery of the lower limbs and the living ability, and promote bone healing.
2020 Vol. 27 (11): 163-165 [Abstract] ( 72 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
167 Clinical effect of combination of traditional Chinese and western medicine treating postmenopausal estrogen receptor-positive advanced breast cancer
CUI De-li
Objective To investigate the clinical effect of combination of traditional Chinese and western medicine treating postmenopausal estrogen receptor (ER)-positive advanced breast cancer.Methods A total of 47 patients with postmenopausal ER-positive advanced breast cancer who were positive for ER and required treatment with Letrozole were enrolled in our hospital from March 2016 to October 2018.According to the random number table method, 23 cases were inclucled in the treatment group and 24 cases in the control group.The treatment group was given Zhibai Dihuang Decoction and Letrozole orally, and the control group was given Letrozole orally.After 2 courses (60 days) treatment, the clinical efficacy, tumor index changes and total incidence of adverse reactions were compared between the two groups.Results There was no significant difference in the effective rate between the treatment group and the control group (P＞0.05).The levels of carbohydrate antigen 15-3 (CA15-3) in two groups were lower than those in each group before treatment, and the differences were statistically significant (P＜0.05).Compared the tumor index CA15-3 after treatment in the two groups, the difference was not statistically significant (P＞0.05).The total incidence of adverse reactions in the treatment group was lower than that in the control group, and the difference was statistically significant(P＜0.05).Conclusion Zhibai Dihuang Decoction combined with Letrozole in the treatment of postmenopausal ER-positive advanced breast cancer has a good clinical effect in the near future, and can reduce the adverse reactions caused by Letrozole treatment.Therefore, the combination of traditional Chinese and western medicine for the treatment of postmenopausal ER-positive advanced breast cancer has a good value.
2020 Vol. 27 (11): 167-169 [Abstract] ( 67 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
170 Analysis of correlation between serum cystatin, urinary microprotein, uric acid and early renal impairment in pregnancy induced hypertension
QIU Xiao-jun; CHEN Ying
Objective To explore the correlation between serum cystatin, uric acid (UA), urinary microprotein (mALB)and early renal impairment in pregnancy induced hypertension.Methods A total of 106 patients with pregnancy induced hypertension admitted to our hospital from March 2015 to August 2018 were selected as the study subjects.According to the endogenous creatinine clearance rate, they was divided into normal renal function group (40 cases) and abnormal renal function group (66 cases), and 60 normal pregnant women were selected as control group at the same time.The levels of serum cystatin-C (Cys-C), mALB and UA in the three groups were compared.The relationship between the above indexes and renal function was analyzed.Results The levels of Cys-C, mALB and UA in abnormal renal function group were higher than those in normal renal function group and healthy control group.The levels of Cys-C, mALB and UA in normal renal function group were higher than those in healthy control group, with statistical differences (P＜0.05).The levels of Cys-C, mALB and UA in abnormal renal function group were higher than those in normal renal function group and healthy control group.The levels of Cys-C, mALB and UA in normal renal function group were higher than those in healthy control group, with statistical differences (P＜0.05).ROC curve (subject working curve) area of Cys-C, mALB and UA were ＞0.5, and the area under Cys-C curve was greater than mALB and UA area,mALB area were greater than UA；the sensibility of Cys-C was higher than that of mALB and UA, and the sensibility of mALB was higher than that of UA, the differences were statistically significant (P＜0.05).The specificity of Cys-C was higher than that of mALB and UA, the difference was statistically significant (P＜0.05)；However, there were no significant differences in specificity between mALB and UA (P＞0.05).Conclusion Early patients with pregnancy-induced hypertension are prone to renal dysfunction, which is characterized by abnormal levels of Cys-C, UA and mALB.These three indicators can effectively diagnose early renal function of pregnancy induced hypertension and can be used as diagnostic indicators of clinical diseases.
2020 Vol. 27 (11): 170-172 [Abstract] ( 72 ) HTML (33 KB)  PDF  (0 KB)  ( 10 )
173 Expression of serine protease 1 in gastric cancer and its influencing factors
JIANG Qiang
Objective To investigate the changes of serine protease 1 (HTRA1) in gastric cancer patients and the influencing factors.Methods A total of 220 patients with gastric cancer clinically diagnosed in our hospital from July 2016 to July 2019 were selected as study objects.The expression of HTRA1 in gastric cancer and distant cancer was detected by immunohistochemistry, and the relationship between HTRA1 expression and clinical characteristics of gastric cancer was analyzed.Results The positive expression rate of HTRA1 protein in gastric cancer tissues (13.18%) was lower than that in distant cancer tissues (86.82%), the difference was statistically significant (P＞0.05).The differences in tumor diameter, invasion depth, smoking history, drinking history and mental state between positive and negative HTRA1 protein expression patients were statistically significant (P＜0.05), while the difference in age, gender, tissue differentiation degree, lymph node metastasis and TNM stage between positive and negative HTRA1 protein expression patients were not statistically significant (P＞0.05).Logistic regression analysis showed that tumor diameter (β=0.532,OR=1.873, 95%CI 0.372-2.711), invasion depth (β=0.837, OR=1.103, 95%CI 0.822-2.014), smoking history (β=0.486,OR=1.569, 95%CI 1.023-2.832), drinking history (β=0.590, OR=1.690, 95%CI 0.934-3.721) and mental state (β=0.829, OR=1.552, 95%CI 1.032-2.831) were independent risk factors affecting gastric cancer (P＜0.05).Conclusion HRA1 protein expression in gastric cancer is related to tumor diameter, invasion depth, smoking history, drinking history and mental state.Tumor diameter, invasion depth, smoking history, drinking history and mental state are all risk factors affecting gastric cancer.
2020 Vol. 27 (11): 173-175转186 [Abstract] ( 79 ) HTML (33 KB)  PDF  (0 KB)  ( 14 )
176 Application of SBAR mode in nursing shift change in intensive care unit
WANG Fu-jun； WANG Jin； GUO Yu-mei； PENG Jun-lan； CAI Li-li ； ZHOU Ling-hong
Objective To explore the application effect of situation-background-assessment-recommendation (SBAR)mode in nursing shift change in intensive care unit.Methods A total of 200 intensive care patients admitted to our hospital from April 2019 to September 2019 were selected as the research objects, and were divided into the control group (n=100) and the experimental group (n=100) according to the random number table method.Patients in the control group received traditional shift change, while in the experimental group, the SBAR mode was used.The incidence of adverse events in nursing, the rate of missed nursing shift change, the duration of shift change, scoring of nurses′ ability to master the disease condition, and total nursing satisfaction were compared between the two groups.Results The incidence of nursing adverse events and missed shifts in the experimental group were lower than those in the control group, and the differences were statistically significant (P＜0.05).The duration of the nursing shift change in the experimental group was shorter than that in the control group, and the difference was statistically significant (P＜0.05).The total satisfaction of the patients in the experimental group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion Reasonable application of the SBAR mode in nursing change shift in the intensive care unit can not only greatly decrease the incidence of nursing events, missed nursing shift change rate, and shorten the duration of shift change, but also can greatly increase the scores of nurses′ ability to master the disease condition and the patients′ satisfaction.
2020 Vol. 27 (11): 176-182 [Abstract] ( 69 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
179 Effect observation of individualized prevention and control on reducing the incidence of hospital infection in general surgery patients
ZENG Wen-ling； XU Lin-feng； LIU Yan
Objective To explore the effect of individualized prevention and control measures on reducing the incidence of hospital infection in general surgery patients.Methods A total of 360 patients underwent surgery who were hospitalized in our department of general surgery from July 2018 to June 2019 were selected as the research objects,and they were divided into the experimental group and the control group according to random number table method,with 180 cases in each group.The experimental group took individualized prevention and control measures, and the control group carried out comprehensive monitoring.The incidence of hospital infection and patient satisfaction were compared between the two groups.Results The total incidence of hospital infection in the experimental group was 1.67%, which was lower than 5.55% in the control group, the difference was statistically significant (P＜0.05).The total satisfaction of the experimental group was 95.00%, which was higher than 77.22% of the control group, the difference was statistically significant (P＜0.05).Conclusion Individualized prevention and control measures can reduce the incidence of hospital infection in patients with general surgery, and improve patient satisfaction, which is worthy of clinical popularization and application.
2020 Vol. 27 (11): 179-182 [Abstract] ( 61 ) HTML (39 KB)  PDF  (0 KB)  ( 12 )
183 Application analysis of PDCA management mode in the monitoring and management of Chinese patent medicine auxiliary drugs
ZENG Hui-fen; OU Huan-jiao
Objective To explore the application of PDCA management mode in the monitoring and management of Chinese patent medicine auxiliary drugs.Methods PDCA cycle management method was used to summarize the current status of the use of proprietary Chinese medicines, summarize problems, find out the reasons, formulate intervention targets and measures, and conduct irrational drug intervention.Statistical analysis was carried out on the use of proprietary Chinese medicines before the implementation of PDCA cycle management (from January to December in 2017)and PDCA cycle management (from January 2018 to June 2019) in our hospital to evaluate the intervention effect and form a normalized management mechanism.Results Since the implementation of PDCA cycle management in 2018, the sales amount of proprietary Chinese medicines in our hospital and its proportion of total sales of medicines had shown a downward trend.The sales amount in 2018 (1152.61 million yuan) was higher than that in 2017 (1931.71 million yuan).The decline was 40.34%.In 2018, the proportion of sales to total sales of medicines (5.05%) decreased by 41.69%compared with 2017 (8.66%).In the first half of 2019, it maintained a downward trend in 2018, reaching the expected intervention target.Conclusion PDCA cycle management can effectively reduce the use of Chinese medicines in hospitals, reduce the burden of patients' drug costs, and promote rational drug use.
2020 Vol. 27 (11): 183-186 [Abstract] ( 56 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
187 Effect of multi-department cooperation in standardizing the management of foreign surgical instruments and implants
HU Mei-jiao; LI Zhen; LIU Jia
Objective To explore the effect of multi-department cooperation in the management of foreign surgical instruments and implants, so as to ensure medical safety and eliminate medical hidden dangers.Methods A total of 1000 packages of foreign instruments and implants managed by the surgical department from June to November 2014 were randomly selected as the control group.From January to June 2015, 1000 packages of foreign instruments and implants managed by multi-department cooperation mode were randomly selected as the observation group.The qualified rate of cleaning and sterilization of foreign instruments and implants, the rate of delay in operation, the leakage rate of implants and the rate of doctors′ satisfaction were compared between the two groups.Results There were no significant differences in the qualified rate of cleaning and sterilization and the leakage rate of implants between the observation group and the control group (P＞0.05), but the delay rate of operation in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05).The satisfaction rate of doctors in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05).Conclusion It is feasible to adopt the standard management mode of multi-department cooperation for foreign surgical instruments and implants.It can effectively improve the work efficiency and quality of foreign surgical instruments and implants, ensure the safety of patients, eliminate medical hidden dangers and improve the quality of nursing.
2020 Vol. 27 (11): 187-189 [Abstract] ( 57 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
190 Effect of nursing safety management on nursing quality in hemodialysis room
BING Lian-kun； WANG Hong； SONG Li-na； SHI Ai-ru
Objective To explore the effect of nursing safety management on the quality of care in hemodialysis room.Methods A total of 86 hemodialysis patients admitted to our hospital from May 2018 to May 2019 were selected for the study, and divided into the reference group (n=43) and the research group (n=43) according to the random number table method with 8 corresponding nursing staff in each group.Routine nursing management and routine rursing+nursing safety management were adopted respectively.The total incidence of adverse events, total nursing satisfaction, awareness of safety knowledge, quality of nursing, operating skills and safety awareness of nursing staff were compared between the two groups.Results The total incidence of adverse events in the study group was 4.65%, lower than that in the control group (23.26%), the difference was statistically significant (P＜0.05).The total nursing satisfaction of patients in the study group was 95.35%, higher than that of the reference group (79.07%), the difference was statistically significant (P＜0.05).The scores of safety knowledge awareness ([92.13±3.45]points) and nursing quality ([88.36±4.27]points)in the study group were higher than those in the control group ([78.24±3.28]and [73.54±5.17]points), with statistically significant differences (P＜0.05).The scores of operating skill level ([93.46±4.21]points) and safety consciousness([94.52±3.17]points) of nursing staff in the study group were higher than those in the control group ([83.14±5.12]and[85.14±3.25]points), with statistically significant differences (P＜0.05).Conclusion Adopting nursing safety management can effectively improve the quality of care in the hemodialysis room, reduce the occurrence of adverse events in hemodialysis patients, and improve their nursing satisfaction.
2020 Vol. 27 (11): 190-192转196 [Abstract] ( 65 ) HTML (36 KB)  PDF  (0 KB)  ( 9 )
193 Application of systemic cognitive therapy in clinical psychological nursing of patients with chronic depression
WAN Hong-ying； LIU Juan
Objective To explore the effect of systemic cognitive therapy technology in clinical psychological nursing of patients with chronic depression.Methods Sixty patients with chronic depression who were hospitalized in our hospital from June 2015 to June 2019 were selected.They were divided into control group and observation group according to the random number table method, 30 cases in each group.Patients in the control group received conventional nursing treatment, and patients in the observation group were additionally provided with systemic cognitive therapy technology on the basis of the control group.The self-rating anxiety scale (SAS) score, self-rating depression scale (SDS) score,negative mood score and positive mood score, and treatment compliance after intervention between the two groups were compared.Results There were no significant differences in SDS or SAS scores before intervention between the two groups(P＞0.05).The scores of SDS and SAS in the two groups after intervention were lower than those before intervention,the SDS and SAS scores of patients in the observation group after intervention were lower than those in the control group,and the differences were statistically significant(P＜0.05).There were no statistical differences in negative mood and positive mood scores before intervention in the two groups (P＞0.05).The scores of negative mood after intervention in the two groups were lower than those before intervention, the negative mood score after intervention in the observation group was lower than that of the control group, and the scores of positive mood after intervention in the two groups were higher than those before intervention, the positive mood score was higher than that in the control group, the differences were statistically significant (P＜0.05).The treatment compliance of patients in the observation group after intervention was higher than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The application of systematic cognitive therapy in clinical psychological nursing of patients with chronic depression can effectively improve their anxiety and depression, dispel the negative mood, and increase the treatment compliance.It is worth promoting and using in clinical practice.
2020 Vol. 27 (11): 193-196 [Abstract] ( 59 ) HTML (35 KB)  PDF  (0 KB)  ( 9 )
197 Application of rapid rehabilitation nursing in patients with cervical cancer surgery
XIONG Dan； ZENG Pin-pin； LI Jun-fang
Objective To study the application effect of rapid rehabilitation nursing in patients with cervical cancer surgery.Methods A total of 90 cases of cervical cancer patients were treated in our hospital from January 2017 to February 2019 were selected.Patients were divided into control group and experimental group according to the random number table method, 45 cases in each group.Routine nursing intervention was performed on the control group；rapid rehabilitation nursing intervention was performed on the experimental group.The improvement of psychological anxiety and depression, the recovery of the patients (the time of first eating, exhausting, defecation, the time of getting out of bed；the time of recovery of gastrointestinal function), the total incidence of postoperative complications, and the proportion of nursing satisfaction between of patients the two groups were compared.Results The scores of depression self-assessment (SDS) and anxiety self-evaluation scale (SAS) were lower in the two groups than those before nursing(P ＜0.05）, and the scores of SAS, SDS in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05).The time of first eating, exhaust, defecation, the time of getting out of bed and the recovery time of gastrointestinal function in the experimental group were shorter than those in the control group, the differences were statistically significant (P＜0.05), the probability of complications in the experimental group was lower than that in the control group (P ＜0.05）, and the total incidence of postoperative complications in the experimental group was lower than that in the control group (P＜0.05）.The proportion of total nursing satisfaction in the experimental group was higher than that in the control group, the difference was statistically significant (P ＜0.05).Conclusion Rapid rehabilitation nursing for patients with cervical cancer surgery is beneficial to improve the occurrence of patients′ bad psychology, promote recovery of patients′ recovery period, reduce the occurrence of complications, and the degree of satisfaction of patients with nursing was improved.
2020 Vol. 27 (11): 197-199 [Abstract] ( 67 ) HTML (34 KB)  PDF  (0 KB)  ( 13 )
200 Effect of motivational interviewing on blood pressure and pregnancy outcomes in pregnant women with hypertension during pregnancy
ZHANG Jia; XIONG Xiao-juan; WANG Jin
Objective To study the effect of motivational interviewing (MI) on blood pressure and pregnancy outcomes in pregnant women with hypertension during pregnancy.Methods A total of 140 pregnant women with hypertension during pregnancy admitted to our hospital from January to December 2018 were enrolled.The random number table method was applied to divide them into control group and observation group, 70 cases in each group.The control group received routine intervention treatment, while the observation group received routine intervention+motivational interviewing treatment.Differences in pregnancy outcomes and nursing satisfaction as well as changes in different indicators between the two groups of patients after different nursing interventions were observed.Results Different nursing interventions were performed in the two groups of patients, the incidences of cesarean section and intrauterine fetal distress in the observation group were lower than those in the control group (35.8%), the differences were statistically significant(P＜0.05).The systolic pressure of the observation group was (121.2±1.5 mmHg), lower than that of the control group of(133.2±3.1) mmHg, the diastolic pressure of the observation group was (79.2±2.4) mmHg, lower than that of the control group of (90.1±3.1) mmHg, the differences were statistically significant (P＜0.05).The urea nitrogen of the observation group was (3.9±1.5) mmol/L, lower than that of the control group (6.1±2.1) mmol/L, the difference was statistically significant (P＜0.05).The creatinine of the observation group was (59.2±19.2) mmol/L, lower than that of the control group of (73.2±24.7) mmol/L, the difference was statistically significant (P＜0.05).The urine microalbumin of the observation group was (45.2±11.9) mmol/L, lower than that of the control group of (90.1±12.3) mg/L, the difference was statistically significant (P＜0.05).The nursing total satisfaction of the observation group (97.1%) was higher than that of the control group (85.6%), and the difference was statistically significant (P＜0.05).Conclusions The intervention of motivational interviewing can be applied on pregnant women with hypertension to significantly improve the patients′ blood pressure and pregnancy outcomes.It is beneficial to improve the nursing satisfaction and it should be clinical promoted.
2020 Vol. 27 (11): 200-202 [Abstract] ( 70 ) HTML (34 KB)  PDF  (0 KB)  ( 13 )
203 Application effect of Sihuang Shuimi in infusion phlebitis and its effect on pain
ZENG Jing-wen
Objective To explore the application effect of Sihuang Shuimi in infusion phlebitis and its effect on pain.Methods Eighty patients with infusion phlebitis treated in our hospital from March 2017 to March 2019 were selected and divided into observation group and control group according to the sequence of the patients′ consultation, 40 cases in each group.In the control group, Magnesium Sulfate (50%) was applied externally, and in the observation group, Sihuang Shuimi was applied.The visual analog scale (VAS) was used to analyze the effect of the two methods.The total nursing effectiveness rate of the two groups was compared.Results The total effectiveness rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).At the time points of 8, 24, 48, and 72 h, the VAS scores of the observation group were lower than those of the control group, with statistical differences (P＜0.05).Conclusion The application of Sihuang Shuimi in infusion phlebitis is remarkable.It can effectively alleviate the local pain felt by patients with infusion phlebitis, and it is worthy of widespread popularization and application in clinic.
2020 Vol. 27 (11): 203-205 [Abstract] ( 77 ) HTML (29 KB)  PDF  (0 KB)  ( 14 )
206 Application effect of nursing health prescription combined with targeted nursing intervention on nursing of patients with decompensated hepatitis B liver cirrhosis
LUO Jin-ju； LIU Hai-fen； LIU Xiao-yun； ZHANG Qiao-ying； WU Yu-bao； YU Xue-mei
Objective To explore the application effect of nursing health prescription joint targeted nursing intervention in the nursing of patients in the period of hepatitis B cirrhosis loss.Methods From January 2017 to December 2018,100 patients with decompensated hepatitis B liver cirrhosis treated in our hospital were selected and divided into observation group (n=50) and control group (n=50) according to the method of random drawing.The control group was treated with routine nursing method, and the observation group was treated with nursing health prescription combined with targeted nursing intervention.The total treatment compliance, self-rating anxiety scale (SAS) and self-rating depression scale (SDS) score and complications were compared between the two groups.Results After nursing intervention, the total compliance rate of treatment in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05).Before nursing, there were no significant differences in SAS, SDS scores between the two groups (P＞0.05)；but the SAS, SDS scores in the two groups after nursing were lower than those before nursing, and the SAS, SDS scores in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).The incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05).Conclusion Nursing health prescription combined with targeted nursing intervention in the nursing of patients with decompensated hepatitis B liver cirrhosis can make patients more compliant with the treatment, and relieve the patients′ negative emotions, reduce the complications, it is worthy of clinical promotion.
2020 Vol. 27 (11): 206-208转212 [Abstract] ( 59 ) HTML (36 KB)  PDF  (0 KB)  ( 5 )
209 Application effect of health education in nursing of bronchial pneumonia in children with microwave therapy apparatus
ZHU Ai-xin； LI Qiao-ru； HUANG Chun-hui； CHEN Qiong； LU Xian-xiu
Objective To explore the application effect of health education in the nursing of children with bronchial pneumonia treated by microwave therapy apparatus.Methods A total of 286 children with bronchial pneumonia treated in our hospital from June 2017 to June 2019 were selected as the research objects.They were divided into the control group (n=143) and the study group (n=143) according to different nursing methods.In the control group, microwave therapy apparatus combined with routine nursing was used, and in the study group, microwave therapy apparatus combined with health education was applied.The nursing effect, compliance, clinical efficacy, satisfaction with clinical nursing, and mastery of health education knowledge were compared between the two groups.Results The time of high fever abatement, time of rales disappearing in the lungs, time to stop coughing, time to return to normal for lungs, and hospital stay in the study group were shorter than those in the control group, the differences were statistically significant (P＜0.05).The nursing compliance, the total satisfaction of the children′s family members on nursing, and the mastery of health education knowledge in the study group were higher than those of the control group, the differences were statistically significant (P＜0.05).The total nursing effective rate of the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The arterial partial pressure of oxygen (PaO2) and forced expiratory volume in 1 second (FEV1) in the study group were higher than those in the control group with statistical differences (P＜0.05).The arterial carbon dioxide partial pressure (PaCO2) of the study group was lower than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion The implementation of health education in the treatment of pediatric bronchial pneumonia with microwave therapy apparatus can not only improve the compliance and efficacy of nursing, but also increase the satisfaction of nursing and enhance the pulmonary function index of children.It is worth popularizing and applying in clinic.
2020 Vol. 27 (11): 209-212 [Abstract] ( 67 ) HTML (38 KB)  PDF  (0 KB)  ( 10 )
213 Effect of comfort nursing on treatment compliance and comfort of patients with psychosis treated modified electroconvulsive therapy
YOU Hui-fang; CHEN Wen-ying; KUANG Yan-zhen
Objective To explore the effect of comfort nursing on patients with mental illness after modified electroconvulsive therapy (MECT).Methods A total of 62 psychiatric patients treated in our hospital from January 2017 to January 2019 were selected and divided into control group and an observation group by throwing the red/yellow doublecolor ball, 31 cases in each group.All patients were treated with MECT.In the control group, conventional nursing was used, while in the observation group, comfort nursing on this basis was adopted.The treatment compliance and comfort of the two groups of patients before and after nursing, the total nursing satisfaction were compared.Results There was no significant difference in comfort score and compliance between the two groups of patients before nursing (P＞0.05).The comfort score of patients in the observation group after nursing was lower than that in the control group, and the difference was statistically significant (P＜0.05).After the nursing, the proportion of patients in the observation group with regular diet, compliance of medication following doctor′s advice, and regular examinations was higher than that in the control group, and the differences were statistically significant (P＜0.05).The total satisfaction of the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The implementation of comfort nursing for patients with mental illness treated by MECT can effectively enhance compliance, improve patients′ comfort, and increase total nursing satisfaction, which is worth clinical promoting.
2020 Vol. 27 (11): 213-215 [Abstract] ( 57 ) HTML (32 KB)  PDF  (0 KB)  ( 5 )
216 Value of nursing intervention based on Wechat platform in patients with colorectal cancer stoma
ZHOU Hong; HE Dan-ling; QIU Huai-yu; GU Dong-dong
Objective To explore the effect of nursing intervention based on Wechat platform in patients with colorectal cancer stoma.Methods From January 2018 to February 2019, 98 patients with colorectal cancer treated in our hospital were selected and divided into control group and research group according to random number table method, 49 cases in each group.The control group was given routine discharge guidance, and the research group was given nursing intervention based on Wechat platform.The self-care ability, abdominal wall anal function score, defecation function and complications were compared between the two groups.Results The scores of self-care ability and artificial anal function in the research group were higher than those in the control group, with statistical differences (P＜0.05).The proportion of defecation regularity in the research group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The incidence of complications in the research group (10.20%) was lower than that in the control group (28.57%), and the difference was statistically significant (P＜0.05).Conclusion The nursing intervention based on Wechat platform can improve the self-care ability of patients with colorectal cancer stoma, improve the artificial anus function and defecation function, and reduce complications.
2020 Vol. 27 (11): 216-218 [Abstract] ( 68 ) HTML (32 KB)  PDF  (0 KB)  ( 13 )
219 Application effect of integrated medical and nursing nursing in patients with acute cerebral infarction
HU Jing; XU Yan; HU Chun-yi
Objective To explore the application effect of integrated medical and nursing care in patients with acute cerebral infarction (ACI).Methods A total of 86 patients with ACI admitted to our hospital from February 2018 to February 2019 were selected as the study subjects.According to the random number table method, the patients were divided into observation group and control group, 43 cases in each group.The control group received routine nursing,while the observation group received integrated medical and nursing.The neurological deficit score (NIHSS), clinical effect, hospitalization time and preparation time for thrombolysis were compared between the two groups.Results The NIHSS score of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05).The total effective rate was 88.4% in the observation group, which was higher than 51.2% in the control group, and the difference was statistically significant (P＜0.05).The preparation time for thrombolysis in the observation group was (3.2±1.4) h and the hospitalization time was (8.3±2.5) d, which were shorter than those in the control group, of (5.7±1.8) h, (14.1±1.9) d, and the differences were statistically significant (P＜0.05).Conclusion The application of integrated medical and nursing in patients with ACI reduce the NIHSS score of patients with more significant clinical efficacy, but also conducive to shorten the preparation time and hospitalization time for thrombolytic therapy,which can be actively applied in clinical practice.
2020 Vol. 27 (11): 219-221 [Abstract] ( 72 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
222 Application effect of cognitive behavior nursing combined with psychological nursing on social phobia patients
HUANG Huan-xin; XIANG Li; XIE Jian-fen; TANG Liu-lan; LI Gui-yun; QIU Hui-ying
Objective To explore the application effect of cognitive behavior nursing combined with psychological nursing on social anxiety disorder patients （SAD）.Methods A total of 60 patients with SAD who were diagnosed and treated in Mental Hospital of Guangzhou Civil Affairs Bureau from June 2018 to June 2019 were selected and divided into the control group and the observation group according to the random number table method, 30 cases in each group.Routine treatment was used in both groups.On this basis, the control group was given conventional nursing, and the observation group was given cognitive behavior nursing combined with psychological nursing on the basis of the control group.The scores of Liebowitz social anxiety scale (LSAS) before and after nursing and the patients′ satisfaction after nursing were compared between the two groups.Results There was no significant difference between the two groups in LSAS score before nursing (P＞0.05).The LSAS scores of patients in the two groups after nursing were lower than those before nursing, the difference was statistically significant (P＜0.05).The LSAS score of the observation group after nursing was lower than that of the control group, with significant difference (P＜0.05).The total satisfaction degree of patients in the observation group was 90.00%, which was higher than that in the control group (63.33%), with significant difference (P＜0.05).Conclusion The application effect of cognitive behavioral nursing combined with psychological nursing in patients with SAD has significant effect, which can improve the LSAS score of patients and improve the satisfaction of patients.
2020 Vol. 27 (11): 222-224 [Abstract] ( 54 ) HTML (31 KB)  PDF  (0 KB)  ( 16 )
225 Application effect of traditional Chinese medicine enema combined with nursing intervention in patients with chronic ulcerative colitis
LI Man-xiang; ZHANG Qiu-xia
Objective To study the effect of traditional Chinese medicine enema combined with nursing intervention in patients with chronic ulcerative colitis (UC).Methods One hundred patients with chronic UC admitted to our hospital from February 2016 to December 2018 were enrolled.They were divided into observation group and control group by principle of random control, 50 cases in each group.The two groups were given Chinese medicine enema.treatment,the control group received routine nursing, the observation group plus nursing intervention on the basis of the control group.The intervention effect of the two groups of patients were observed, the self-rating anxiety scale (SAS) and the self-rating depression scale (SDS) were used to evaluate the two groups of patients the psychological state before and after the nursing.The clinical treatment effect and the improvement time of abdominal pain, diarrhea, pus and bloody stools, mucus and anal swelling were compared between the patients of the two groups.Results The total effective rate was 98.0% in the observation group which was higher than that of 66.0% in the control group, the difference was statistically significant (P＜0.05）.After the intervention, the SAS and SDS scores of the observation group were lower than those before the intervention, the SAS and SDS scores of the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05）.The improvement time of the symptoms in the observation group was shorter than that of the control group, the differences were statistically significant (P＜0.05）.Conclusion Chinese medicine enema combined with nursing intervention for patients with chronic UC can significantly improve the clinical symptoms and improve the psychological state, which is worthy of clinical promotion.
2020 Vol. 27 (11): 225-227 [Abstract] ( 65 ) HTML (33 KB)  PDF  (0 KB)  ( 14 )
228 Application effect of targeted preventive nursing in the treatment of lymphoid cancer patients with Rituximab Injection
HAN Yang
Objective To explore the effect of targeted preventive nursing in the treatment of lymphoma patients with Rituximab Injection.Methods From January 2017 to December 2018, 60 patients with lymphoid cancer treated with Rituximab Injection in our hospital were selected as subjects and divided into control group (n=30) and observation group (n=30).Patients in observation group were treated with preventive nursing and patients in control group were treated with basic nursing.The incidence of adverse reactions and the changes of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) score before and after nursing were compared between the two groups.Results The incidence of adverse reactions in the observation group was 6.67%, lower than that in the control group (36.67%)，the difference was statistically significant (P＜0.05).The SAS and SDS scores of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05).Conclusion The application of Rituximab Injection in the chemotherapy of patients with lymphatic cancer plays an obvious role in the implementation of targeted preventive nursing, which can significantly reduce the occurrence of adverse reactions in patients, significantly improve the psychological state of patients, and significantly improve the nursing effect.
2020 Vol. 27 (11): 228-230 [Abstract] ( 61 ) HTML (31 KB)  PDF  (0 KB)  ( 15 )
231 Application effect of early rehabilitation nursing in patients with cerebral hemorrhage
CHEN Qiao-ru； YE Wan-fen

Objective To explore the effect of early rehabilitation nursing on postoperative patients with cerebral hemorrhage (CH).Methods Eighty patients with CH admitted to our hospital from April 2018 to February 2019 were enrolled in the study.They were divided into control group and observation group according to the random number table method, 40 cases in each group.Surgical treatment was performed in both groups, and the control group received routine nursing after operation.The observation group received early postoperative rehabilitation nursing.The daily living activity scale (Barthel) score, upper limb muscle strength and lower limb muscle strength were compared between the two groups.Results The Barthel score of the two groups after nursing was higher than that before nursing, and the Barthel score of the observation group after nursing was higher than that of the control group, the differences were statistically significant (P＜0.05).The proportions of patients with upper and lower limb muscle strength ≥grade Ⅲin the observation group were higher than those in the control group, with statistical differences (P＜0.05)；the proportions of patients with upper and lower limb muscle strength ≤grade Ⅱin the observation group were lower than those in the control group, with statistical differences (P＜0.05).Conclusion The application of early rehabilitation nursing in the process of nursing patients with CH is ideal, improve the patient′s physical activity ability and self-care ability, thus improving the quality of life of patients, and is more suitable for extensive clinical practice.
2020 Vol. 27 (11): 231-233转237 [Abstract] ( 59 ) HTML (34 KB)  PDF  (0 KB)  ( 11 )
234 Application effect of psychological nursing intervention in breast cancer patients
WANG Jun-hua
Objective To explore the effect of psychological nursing intervention on breast cancer patients.Methods Sixty breast cancer patients who were treated in our hospital from July 2016 to June 2019 were selected as the study subjects.They were divided into control group (n=30) and observation group (n=30) by digital random table method.Patients in the control group received routine nursing and patients in the observation group underwent routine nursing+psychological nursing intervention.The total treatment compliance, negative emotional score, patient satisfaction and quality of life scores were compared between the two groups.Results The total treatment compliance of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).There was no significant difference in the degree of knowledge of health knowledge between the two groups before treatment (P＞0.05).The scores of health knowledge awareness of the two groups were higher than those before the nursing, and the differences were statistically significant (P＜0.05).The health knowledge awareness score of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05).The anxiety scores and depression scores of the two groups were lower than those before the nursing, and the differences were statistically significant (P＜0.05).The scores of anxiety and depression in the two groups were lower than those before nursing, the scores of anxiety and depression in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).The patient satisfaction scores in the observation group was higher than that in the control group, the quality of life score of the observation group was higher than that of the control group, and differences were statistically significant (P＜0.05).Conclusion Psychological nursing intervention for breast cancer patients can achieve ideal results.On the one hand, it can alleviate the negative emotions of patients and improve the satisfaction of patients；on the other hand, it can improve the patient′s treatment compliance, and thus improve the quality of life of patients, and the overall advantage is remarkable, is worth the clinical promotion and the application.
2020 Vol. 27 (11): 234-237 [Abstract] ( 67 ) HTML (35 KB)  PDF  (0 KB)  ( 7 )
238 Application effect of comprehensive nursing on elderly patients with acute myocardial infarction complicated with shock treated by IABP
DENG Cai-ping； WU Zao-lian； LIANG Ying-ying
Objective To explore the application effect of comprehensive nursing on elderly patients with acute myocardial infarction (AMI) complicated with shock treated by intra-aortic balloon pump (IABP).Methods Eighty elderly patients with AMI complicated by shock admitted to our hospital from January 2017 to June 2019 were selected and divided into control group and study group according to random number table method, 40 cases in each group.Both groups were treated with IABP, the control group were given routine nursing, and the study group were given comprehensive nursing.The changes of heart rate, diastolic blood pressure, systolic blood pressure and complications such as infection, balloon rupture, gastrointestinal bleeding and puncture site bleeding before and after intervention were compared between the two groups.Results There were no significant differences in heart rate, diastolic blood pressure and systolic blood pressure between the two groups before intervention (P＞0.05).After intervention, the heart rate of the two groups was lower than before intervention, and the diastolic blood pressure and systolic blood pressure were higher than before intervention (P＜0.05).The heart rate of the study group was lower than that of the control group, and the diastolic blood pressure and systolic blood pressure were higher than that of the control group, the differences were statistically significant (P＜0.05).The incidence of complications in the study group (5.00%) was lower than that in the control group (27.50%), and the difference was statistically significant (P＜0.05).Conclusion Comprehensive nursing applied to the elderly patients with AMI complicated with shock treated by IABP can help stabilize the hemodynamics, reduce the risk of complications and help the patients to pass the catheterization period smoothly.
2020 Vol. 27 (11): 238-240 [Abstract] ( 60 ) HTML (30 KB)  PDF  (0 KB)  ( 6 )
241 Application of comprehensive nursing intervention in pregnant women with gestational diabetes mellitus
CHEN Jin-xiu； WEI Xiao-li ； SHAN Yue-ling； LI Dong； ZHANG Su-chun； WENG Yi
Objective To explore the application effect of comprehensive nursing intervention in pregnant women with gestational diabetes mellitus (GDM).Methods Altogether 800 cases pregnant women with GDM admitted to the our hospital from January 2017 to December 2018 were selected as research objects.They were randomly divided into control group (n=400) and observation group (n=400).The control group adopted conventional nursing method, and the observation group adopted comprehensive nursing intervention method.Blood glucose leakage rate, maternal and infant separation rate, cesarean section rate and neonatal complications were compared between the two groups.Results The blood glucose leakage rate, maternal and child separation rate and cesarean section rate in the observation group were lower than those in the control group, with statistical differences (P＜0.05).The incidence of premature, neonatal asphyxia and macrosomia in the observation group were lower than those in the control group, with statistical differences(P＜0.05).The total satisfaction of the observation group was 92.8%, higher than that of the control group (83.5%), and the difference was statistically significant (P＜0.05).Conclusion Comprehensive intervention can significantly reduce the rate of blood glucose leakage in GDM pregnant women, improve the compliance of blood glucose monitoring, reduce the rate of cesarean section and maternal and infant separation, reduce neonatal complications, improve the pregnancy outcome, and it does not only reduce the economic burden, but also improve the satisfaction of GDM pregnant women.
2020 Vol. 27 (11): 241-244 [Abstract] ( 67 ) HTML (38 KB)  PDF  (0 KB)  ( 12 )
245 Influence of diabetes health education on treatment compliance and blood glucose control of patients with type 2 diabetes mellitus
ZHAO Yang
Objective To explore the influence of diabetes health education on treatment compliance and blood glucose with type 2 diabetes mellitus (T2DM).Methods The clinical data of 80 patients with T2DM admitted to our hospital from February 2018 to June 2019 were analyzed retrospectively and divided into observation group (n=40) and control group (n=40) with different nursing methods.The control group was received routine nursing, the observation group was received diabetes health education.Then the treatment compliance in the two groups during the intervention, the control of blood glucose index and the complications occurred in the two groups during the intervention were compared.Results The total treatmentcompliance of the observation group during the treatment was 97.5%, which was higher than 77.5% that of the control group for 77.5%, the difference was statistically significant (P＜0.05).The fasting blood glucose and 2-hour postprandial blood glucose of the observation group after the intervention were lower than those of the control group (P＜0.05), and the pasting lisulin (FINS) level was higher than that of the control group, the incidence of hyperglycemia, hypoglycemia, ketoacidosis and hyperosmolar coma in the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).Conclusion For patients with T2DM, the implementation of diabetes health education intervention can better improve treatment compliance, maintain blood sugar stability and reduce the incidence of complications.
2020 Vol. 27 (11): 245-247 [Abstract] ( 70 ) HTML (31 KB)  PDF  (0 KB)  ( 15 )
248 Application effect of anesthesia nursing integrated management mode in the perioperative period of patients with hypertention
XU Bao-jun; XIAO Ping-xia
Objective To explore the application effect of anesthesia nursing integrated management mode in the perioperative period of patients with hypertention.Methods Eighty cases patients with hypertension underwent operation in our hospital from July 2018 to July 2019 were selected.According to the simple random grouping method, they were divided into observation group and control group, 40 cases in each group.During the whole operation process, the control group was given routine anesthesia nursing management, while the observation group was given integrated management mode nursing.The time of anesthesia resuscitation, the incidence of complications and Steward score between two groups were observed.Results The recovery time of anesthesia in the observation group was shorter than that in the control group, the incidence of complications was lower than that in the control group, and the Steward score in the observation group was higher than that in the control group, with statistical differences (P＜0.05).Conclusion The application of integrated management mode of anesthesia and nursing in anesthesia resuscitation room of patients with hypertension has good effect, which is helpful to the recovery of patients after anesthesia, can effectively shorten the recovery time of patients, reduce the incidence of complications, and has high popularization value.
2020 Vol. 27 (11): 248-250 [Abstract] ( 59 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
251 Effect of midwifery nursing on delivery quality of parturients
MENG Qing-na
Objective To explore the effect of midwifery nursing on delivery quality of parturients.Methods A total of 106 healthy parturients admitted to our hospital from December 2017 to November 2018 were selected as the research objects, and divided into two groups by odd and even numbers grouping method.The control group (n=53) was given traditional delivery care, and research group (n=53) was given midwifery care, and the incidence of maternal and infant complications, childbirth outcomes, birth process and health status of newborns were compared.Results The incidence rates of postpartum hemorrhage, numbness and pain of lower limbs and neonatal respiratory distress syndrome in the research group were lower than those in the control group, the differences were statistically significant (P＜0.05), while there was no significant difference between the two groups in incidence rate of postpartum depression (P＞0.05).There was no significant difference between the two groups in natural delivery rate (P＞0.05).The first, second and total stages of labor in the research group were shorter than those in the control group，the differences were statistically significant(P＜0.05).The neonatal Apagr score in the research group was higher than that in the control group，the difference was statistically significant (P＜0.05).Conclusion Midwifery nursing has prominent advantages in improving the quality of delivery.It can effectively prevent complications, improve the natural delivery rate, shorten the birth process and improve the health status of newborns.It is worth learning.
2020 Vol. 27 (11): 251-253 [Abstract] ( 68 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
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