丝氨酸蛋白酶1在胃癌组织中的表达及其影响因素分析

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Abstract Objective To investigate the changes of serine protease 1 (HTRA1) in gastric cancer patients and the influencing factors.Methods A total of 220 patients with gastric cancer clinically diagnosed in our hospital from July 2016 to July 2019 were selected as study objects.The expression of HTRA1 in gastric cancer and distant cancer was detected by immunohistochemistry, and the relationship between HTRA1 expression and clinical characteristics of gastric cancer was analyzed.Results The positive expression rate of HTRA1 protein in gastric cancer tissues (13.18%) was lower than that in distant cancer tissues (86.82%), the difference was statistically significant (P＞0.05).The differences in tumor diameter, invasion depth, smoking history, drinking history and mental state between positive and negative HTRA1 protein expression patients were statistically significant (P＜0.05), while the difference in age, gender, tissue differentiation degree, lymph node metastasis and TNM stage between positive and negative HTRA1 protein expression patients were not statistically significant (P＞0.05).Logistic regression analysis showed that tumor diameter (β=0.532,OR=1.873, 95%CI 0.372-2.711), invasion depth (β=0.837, OR=1.103, 95%CI 0.822-2.014), smoking history (β=0.486,OR=1.569, 95%CI 1.023-2.832), drinking history (β=0.590, OR=1.690, 95%CI 0.934-3.721) and mental state (β=0.829, OR=1.552, 95%CI 1.032-2.831) were independent risk factors affecting gastric cancer (P＜0.05).Conclusion HRA1 protein expression in gastric cancer is related to tumor diameter, invasion depth, smoking history, drinking history and mental state.Tumor diameter, invasion depth, smoking history, drinking history and mental state are all risk factors affecting gastric cancer.

Key words： Gastric cancer Serine proteinase 1 Related factors Prognosis

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	JIANG Qiang

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JIANG Qiang. Expression of serine protease 1 in gastric cancer and its influencing factors[J]. 中国当代医药, 2020, 27(11): 173-175转186.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I11/173

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