|
|
|
| Effect of Propranolol combined with Octreotide on hemodynamics and hemostatic effect in patients with liver cirrhosis and upper gastrointestinal bleeding |
| LI Xiao-qing |
| Department of Gastroenterology, Fengcheng People′s Hospital, Jiangxi Province, Fengcheng 331100, China |
|
|
|
|
Abstract Objective Upper gastrointestinal bleeding was a common complication in liver cirrhosis, and its treatment has always been a key clinical concern.In this study, Propranolol combined with Octreotide was used to explore its effect in patients with liver cirrhosis and upper gastrointestinal bleeding.Methods Sixty-six patients with liver cirrhosis accompanied with upper gastrointestinal bleeding who were treated in our hospital from March 2017 to June 2019 were selected as the research subjects.They were divided into control group (n=33) and observation group (n=33) according to the random number table method.In the control group, Octreotide was used, and in the observation group, Propranolol combined with Octreotide was applied.The indexes of left gastric vein, splenic vein，portal vein and hemostatic effect of the two groups were compared.Results The diameter of the left gastric vein and the shunt index in the observation group after treatment were lower than those in the control group, and the differences were statistically significant(P＜0.05).The diameter and blood flow of the splenic vein and portal vein in the observation group were lower than those in the control group, and the average speed was higher than that in the control group, with statistical differences(P＜0.05).The hemostatic time in the observation group was shorter than that in the control group, and the difference was statistically significant (P＜0.05).The re-bleeding rate two days after therapy in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The use of Propranolol combined with Octreotide in the treatment of upper gastrointestinal bleeding in liver cirrhosis can shorten the hemostatic time, reduce the re-bleeding rate after two days, and improve the indexes of the left gastric vein, splenic vein and portal vein of patients.
|
|
|
|
|
|
| [1] |
范红顺，熊志娇，马超，等.肝硬化患者并发上消化道出血的风险因素及预后因素分析[J].解放军预防医学杂志，2019，37（2）：16-18.
|
| [2] |
范子玲.肝硬化门静脉高压并发上消化道出血的风险因素分析[J].解放军预防医学杂志，2019，37（3）：105-106，108.
|
| [3] |
李艳芳，刘灵军，程星，等.肝硬化食管静脉曲张破裂出血危险因素分析[J].实用医院临床杂志，2019，16（1）：41-44.
|
| [4] |
卢伟，杨超，张嘉诚，等.CO2楔入肝静脉造影在肝硬化急性上消化道出血的TIPS 术中的作用[J].中国医药导报，2019，16（10）：84-87.
|
| [5] |
黄絮，张丽霞，张颖，等.老年肝硬化门静脉高压并发上消化道出血的相关因素[J].中国老年学杂志，2019，39（1）：84-86.
|
| [6] |
林秀清，吴伟，金瑞放，等.经颈静脉肝内门体静脉分流术联合胃冠状静脉栓塞术治疗肝硬化门静脉高压症上消化道出血的疗效分析[J].中华普通外科杂志，2019，34（3）：217-221.
|
| [7] |
中华医学会肝病学分会，中华医学会消化病学分会，中华医学会内镜学分会.肝硬化门静脉高压食管胃静脉曲张出血的防治指南[J].临床肝胆病杂志，2016，32（2）：203-219.
|
| [8] |
涂家红，张明清，赵斌.急性上消化道出血死亡相关危险因素分析[J].中国急救医学，2018，38（2）：152-158.
|
| [9] |
王柳青，李盛楠，张国顺.肝硬化并发首次上消化道出血致命的危险因素分析[J].海南医学院学报，2019，25（6）：451-454，458.
|
| [10] |
Fabricius R，Svenningsen P，Hillings J，et al.Effect of transfusion strategy in acute non-variceal upper gastrointestinal bleeding：a nationwide study of 5861 hospital admissions in Denmark[J].World J Surg，2016，40（5）：1129-1136.
|
| [11] |
王亚洁，艾迎春，朱艳丽，等.肝硬化消化道出血及出血后并发症治疗的临床研究[J].肝脏，2019，24（1）：35-39.
|
| [12] |
吴亚玲，朱建勋，陈艳艳.奥曲肽联合凝血酶治疗肝硬化合并上消化道出血的疗效及对患者止血效果、不良反应的影响[J].现代消化及介入 诊疗，2019，24（3）：271-274.
|
| [13] |
何毅，董卫国.奥曲肽联合普萘洛尔治疗肝硬化上消化道出血疗效的meta分析[J].职业与健康，2015，31（3）：332-335.
|
| [14] |
施媛，张仪，胡月.奥曲肽联合普萘洛尔治疗肝硬化上消化道出血的疗效和对脾静脉与门静脉内径及血流的影响[J].医学临床研究，2018，35（8）：1575-1577.
|
| [15] |
王鹏，王波，南鹏，等.奥曲肽联合普萘洛尔治疗肝硬化上消化道出血的疗效及对血流动力学的影响[J].中国临床医生杂志，2019，47（3）：292-294.
|
|
|
|
