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| Applied value analysis of thin-cytologic test and high-risk human papilloma virus examination for screening of cervical cancer |
| PAN Shao-xia SHU Qing |
| Department of Laboratory,Qingyuan Hospital of Traditional Chinese Medicine, Guangdong Province, Qingyuan 511500,China |
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Abstract Objective To analyze the application value of thin-cytologic test (TCT) and high-risk human papilloma virus (HPV) examination for screening of cervical cancer.Methods A total of 260 cases of cervical cancer screening in our hospital from January 2018 to March 2019 were selected as the study subjects.All patients received TCT, HPV examination and pathological biopsy.The sensitivity, specificity and coincidence rate of TCT and HPV in single or combined disease examination were evaluated by pathological biopsy results as the gold standard of disease diagnosis.Results Pathological examination indicated 133 cases inflammation, 119 cases cervical intraepithelial neoplasia (CIN) and 8 cases cervical cancer.The diagnosis accordance rate, sensitivity and specificity based on HPV was 78.46%, 73.08%and 86.54%；the diagnosis accordance rate, sensitivity and specificity based on TCT was 85.38%, 83.09% and 87.90%；the diagnosis accordance rate, sensitivity and specificity based on combined examination was 96.92%, 96.85% and 96.99%.The diagnosis accordance rate, sensitivity and specificity of combined examination were higher than those of HPV or TCT, with statistically significant differences (P＜0.05).Conclusion For suspected cervical cancer patients, the combined examination of HPV and TCT has higher diagnosis accordance rate, sensitivity and specificity, providing references on clinical diagnosis.It is worthy of promotion.
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