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Quick Search     Adv Search 2020 Vol. 27, No. 28 Published: 2020-10-08   4 Effect of Wenyang Sanxian Decoction on the contents of hydroxyproline and transforming growth factor-β1 in lung tissue of mice with pulmonary interstitial fibrosis induced by Bleomycin ZHU Xiao-long； QIU Nian-nian； HU Qi-gui Objective To explore effect of Wenyang Sanxian Decoction on the contents of hydroxyproline (Hyp) and transforming growth factor-β1(TGF-β1)in lung tissue of mice with pulmonary interstitial fibrosis induced by Bleomycin.Methods Bleomycin (0.2-0.3 ml, 5 mg/kg) was injected into C57BL/6 mice through the trachea to establish a pulmonary interstitial fibrosis model. The successful 18 pulmonary fibrosis mice were randomly divided into model group,Wenyang Sanxian Decoction low, medium and high dose groups [5.6625, 11.3250, 22.6500 mg/(kg·d)], positive group[15 mg/(kg·d) Methylprednisolone], with 3 mice in each group. In addition, sham operation and normal group were established, with 3 mice in each group. The contents of Hyp and TGF-β1 in lung tissue were detected by enzyme linked immunosorbent assay (ELISA). Results The contents of Hyp and TGF-β1 in the model group were higher than those in the normal group and sham group, the differences were statistically significant (P＜0.05). The contents of Hyp and TGFβ1 in the Wenyang Sanxian Decoction low, medium and high dose groups and positive group were lower than those in the model group, the differences were statistically significant (P ＜0.05). The contents of Hyp and TGF-β1 in the Wenyang Sanxian Decoction middle, high dose groups and positive group were higher than those in the Wenyang Sanxian Decoction low dose group, the differences were statistically significant (P＜0.05). The contents of Hyp and TGF-β1 in the Wenyang Sanxian Decoction high dose group and positive group were lower than those in the Wenyang Sanxian Decoction middle dose group, the differences were statistically significant (P＜0.05). Conclusion A certain dose of Wenyang Sanxian Decoction could improve the pulmonary interstitial fibrosis of C57BL/6 mice by reducing the contents of Hyp and TGF-β1. 2020 Vol. 27 (28): 4-7 [Abstract] ( 36 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 8 Comparison of pregnancy outcomes of frozen-thawed embryo transfer at different timings LIANG Li-xia； LIU Jun-fen； FAN Jun-mei； ZHANG Zhi-ping； ZHANG Xiu-ping Objective To compare the pregnancy outcomes of frozen-thawed embryo transfer at different times after oocyte retrieval, and to explore the earliest transplanting time for frozen-thawed embryo transfer. Methods Retrospective analysis of patients who received in vitro fertilization embryo transfer (IVF-ET) at the Reproductive Medicine Center of Women Health Center of Shanxi from January 1 to June 30, 2018 was conducted. Patients who met the inclusion/exclusion criteria of this study were divided into two groups according to the timing of frozen-thawed embryo transfer(FET), with 75 patients in group A who were given FET at the first menstrual cycle after oocyte retrieval, and 165 patients in group B who were given FET after ovaries recovered to the level before superovulation. Ovarian hyperstimulation syndrome (OHSS) classification, endometrial preparation and pregnancy outcomes were compared between the two groups. Results There was no significant difference in OHSS classification between the two groups after oocyte retrieval(P＞0.05). The days of using Estradiol Tablets in group A was shorter than that in group B, and the dosage of Estradiol Tablets was less than that in group B, the differences were statistically significant (P＜0.01). The ovarian volume in group A was larger than that in group B on the day of transplantation, with statistically significant difference (P＜0.01).There were no significant differences in the clinical pregnancy rate, embryo implantation rate, twin rate, early miscarriage rate, late miscarriage rate, premature birth rate and delivery rate between the two groups (P＞0.05). Conclusion FET at the first menstrual cycle after oocyte retrieval does not affect the pregnancy outcomes of patients whose OHSS classification after oocyte retrieval is none, mild and moderate. 2020 Vol. 27 (28): 8-12 [Abstract] ( 27 ) HTML (46 KB)  PDF  (0 KB)  ( 8 ) 13 Clinical effect comparison of anatomical locking steel plate and reconstructed steel plate in treatment of Robinson ⅡB clavicle fracture YANG Zhi-qiang； CHEN Yan-zhi； BAI Lin-gang ；SU Yao-hui； ZHANG Chun-yu Objective To compare the clinical effect of reconstructed steel plate and anatomical locking steel plate in treatment of Robinson ⅡB clavicle fracture. Methods Retrospective analysis was performed on the clinical data of 69 patients with Robinson ⅡB clavicle fracture admitted to our hospital from January 2016 to December 2018, according to the choice of steel plate, they were divided into reconstructed steel plate group (33 cases) and anatomic locking steel plate group (36 cases). The operation time, intraoperative blood loss, Constant score of shoulder joint, fracture healing time and incidence of delayed incision healing, bone nonunion and internal plant complications (screw loosening and plate fracture) were compared between the two groups. Results The operation time of the anatomical locking steel plate group was shorter than that of the reconstructed steel plate group, and the difference was statistically significant (P＜0.05). There was no significant difference in intraoperative blood loss between the two groups (P＞0.05). The postoperative fracture healing time in the anatomical locking steel plate group was shorter than that in the reconstructed steel group, and the difference was statistically significant (P＜0.05). There was no significant difference in the Constant score of the shoulder joint between the two groups (P＞0.05). In the reconstructed steel plate group, 1 case of delayed incision healing, 1 case of bone nonunion, 1 case of screw loosening, and 5 cases of steel plate fracture occurred, but no related complications occurred in the anatomical locking steel plate group, the total incidence of complications in the anatomical locking steel plate group was lower than that in the reconstructed steel plate group, the difference was statistically significant (P＜0.05). Conclusion Compared with the reconstructed steel plate, the anatomical locking steel plate in the treatment of Robinson ⅡB clavicular fracture has the advantages of stable fixation, fast healing, fewer complications related to the steel plate, which is worthy of clinical recommendation. 2020 Vol. 27 (28): 13-16 [Abstract] ( 32 ) HTML (36 KB)  PDF  (0 KB)  ( 11 ) 17 Meta-analysis of effect and safety of Escitalopram and Paroxetine in the treatment of post-stroke depression FANG Zhi-rong； LU Jin-xin； WAN Fang； YIN Yan-wei Objective To systematically evaluate the effect and safety of Escitalopram and Paroxetine in the treatment of post-stroke depression (PSD). Methods The randomized controlled trials (RCTs) of Escitalopram and Paroxetine for treating PSD were retrieved in PubMed, Cochrane Library, Wanfang database, CBM, CNKI, Google Scholar, Baidu Scholar published from the establishment of the database to November 2019 by computer. After extracting the data and evaluating the quality, the RevMan 5.3 software was used to conduct Meta-analysis on the data. Results Finally 9 RCTs were included, involving 765 patients. The results of Meta-analysis showed that the Hamilton depression rating scale(HAMD) score in the experimental group decreased more than that in the control group after 1 week of treatment, and the difference was statistically significant (SMD=-0.83, 95%CI[-1.06, -0.60], Z=7.05, P＜0.000 01). After 2, 4, 6 or 8 weeks of treatment, there were no significant differences in HAMD scores between the two groups (P＞0.05). There was no statistically significant difference in the effective rate between the two groups after 6 or 8 weeks of treatment (RR=1.03, 95%CI[0.98, 1.09], Z=1.12, P=0.26). The incidence rates of dry mouth, nausea, headache, and constipation in the experimental group were lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Escitalopram has the same effect as Paroxetine in the treatment of PSD, but Escitalopram has a faster onset. 2020 Vol. 27 (28): 17-20转32 [Abstract] ( 28 ) HTML (41 KB)  PDF  (0 KB)  ( 8 ) 21 Research progress on biomarkers of Alzheimer′s disease HUANG Xiao-yu； LU Ye； BAI Xue Alzheimer′s disease (AD) is the most common neurodegenerative disease. It is mainly manifested in symptoms such as memory loss, cognitive dysfunction, and gradual loss of self-care ability. The pathogenesis of AD is not clear at present. The pathological mechanism hypotheses with high agreement include β-amyloid (Aβ) deposition, tau protein hypothesis, inflammatory mechanism, and cholinergic hypothesis. AD is an irreversible disease. At present,there are no drugs that can cure or delay the disease process. Therefore, in the clinic, early screening and diagnosis are important for the prevention and treatment of AD. This article reviews the research progress of biomarkers closely related to the pathological mechanism of AD in order to provide a basis for the early diagnosis of AD. 2020 Vol. 27 (28): 21-24 [Abstract] ( 30 ) HTML (45 KB)  PDF  (0 KB)  ( 9 ) 25 New progress in clinical application for the diagnosis and treatment of gastroesophageal reflux disease from the Governor Vessel PAN Wei-Bing； BAI Xing-hua By reviewing the relevant literature on the diagnosis and treatment of gastroesophageal reflux disease(GERD) by using Governor Vessel in recent years, this paper comprehensively combs the experience, and expounds it from three aspects: the tenderness rule, therapeutic effect and mechanism between GERD and Governor Vessel. It is considered that there is a regular distribution of tenderness response in patients with GERD, especially in the segment of T5-T7, which provides a theoretical basis for the diagnosis of GERD in traditional Chinese medicine. Governor Vessel can achieve a good clinical effect in the treatment of GERD, reduce the symptoms of patients, improve the bad mood of tension and anxiety, fundamentally solve the problem of reflux, improve the quality of life, and the therapeutic effect and markedly effective rate are better than Western medicine treatment alone. Western medicine believes that there is"visceral-somatic reflex" between spine (dorsal segment of Governor Vessel) and viscera, and one of the core contents of traditional Chinese meridian theory is "meridian point-viscera correlation", which is the basis and possible mechanism of Governor Vessel in the diagnosis and treatment of GERD. 2020 Vol. 27 (28): 25-28 [Abstract] ( 39 ) HTML (44 KB)  PDF  (0 KB)  ( 12 ) 29 Role of levator ani movement in the rehabilitation of postoperative anal fistula operation based on biofeedback technology HUANG Juan； WU Xu-xiong Anal fistula operation will inevitably cause different degrees of sphincter injury and different degrees of dysfunction of stool control. The common complication are poor stool control, mostly manifested as anal exudate, loose stools, poor exhaust control, degree and mild bowel incontinence is similar. Biofeedback is a conservative treatment that requires lifestyle adjustments and medications, and is a first-line treatment for fecal incontinence. In recent years, international experts have recommended biofeedback as the gold standard for the treatment of fecal incontinence. Anal levator exercise is a simple and practical method of anal functional exercise, which has the dual role of preventing and treating anal diseases. Clinically, it can be seen in the application of levator anus exercise for constipation, postoperative anal swell, etc., and its effectiveness has been proven through research. Lifting the anus based on biofeedback can effectively help patients with anal fistula to recover after operation. The author believes that the use of high-resolution anorectal pressure measurement as an evaluation method, through the mode of action of biofeedback therapy, regulates patients to carry out effective levator movements, improves dysfunction of stool control after anorectal disease, and maximize the recovery of anal function, save medical resources, reduce patients′ financial burden, and improve patient satisfaction. 2020 Vol. 27 (28): 29-32 [Abstract] ( 34 ) HTML (34 KB)  PDF  (0 KB)  ( 10 ) 33 Influence of Orem self-care theory on postoperative negative emotion,self-care ability and adverse reactions in cervical cancer patients with chemotherapy WU Qiu-zhu Objective To investigate the influence of Orem self-care theory on postoperative negative emotion, selfcare ability and adverse reactions in cervical cancer patients with chemotherapy. Methods A total of 50 patients with cervical cancer who underwent postoperative chemotherapy in our hospital from January 2018 to June 2019 were selected as the subjects. All the patients were divided into the control group and the observation group according to the random number table method, with 25 cases in each group. Routine nursing was performed in the control group, and Orem self-care theory nursing was performed in the observation group. The negative emotion, self-care ability and adverse reactions were compared between the two groups. Results The scores of Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) after intervention in the observation group ([13.11±3.41], [15.43±4.53] points) were lower than those in the control group ([16.24±4.13], [21.13±5.26] points), with statistically significant differences (P＜0.05).The score of exercise of self-care agency(ESCA)in the observation group was higher than that in the control group,and the total incidence of adverse reactions (16.00%) in the observation group was lower than that in the control group(60.00%), with statistically significant differences (P＜0.05). Conclusion The application of Orem self-care theory in cervical cancer patients with chemotherapy can achieve better nursing effects, improve negative emotion, mobilize subjective initiative, increase self-care ability and reduce adverse reactions, which is worthy of clinical promotion. 2020 Vol. 27 (28): 33-35转42 [Abstract] ( 33 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 36 Clinical effect of Longdan Xiegan Decoction and Desonide Cream in the treatment of vulvar squamous epithelial hyperplasia QIU Wen-fang；CHEN Ya-li； LIU Ju-ying；QIU Jian-wen Objective To explore the clinical effect of Longdan Xiegan Decoction combined with Desonide Cream in the treatment of vulvar squamous epithelial hyperplasia. Methods From August 2018 to August 2019, a total of 50 patients with vulvar squamous epithelial hyperplasia in our hospital were selected as the research objects, they were divided into the control group (n=25) and the observation group (n=25) by red violet dichroism. The control group was treated with Desonide Cream. The observation group was treated with the Longdan Xiegan Decoction combined with Desonide Cream. The efficacy, recurrence rates and total adverse reaction rates of the two groups were compared. Results The total effective rate of the observation group was 92.00%, which was higher than that of the control group (68.00%), the difference was statistically significant (P＜0.05). The recurrence rate of the observation group was 4.35%, which was lower than that of the control group (35.29%), the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the observation group (12.00%) and the control group (16.00%). Conclusion Longdan Xiegan Decoction combined with Desonide Cream can significantly improve the efficacy of vulvar squamous epithelial hyperplasia, reduce the recurrence rate, and has good safety. 2020 Vol. 27 (28): 36-38 [Abstract] ( 35 ) HTML (32 KB)  PDF  (0 KB)  ( 10 ) 39 Effect of cytokine-induced killer combined with chemotherapy in the treatment of middle and advanced lung cancer and its influence on immune function and B7H4 protein level HUANG Lan； LIU Ji-bin Objectives To investigate the clinical effect of cytokine-induced killer (CIK) combined with chemotherapy in the treatment of middle and advanced lung cancer and the influence on immune function and B7H4 protein level.Methods A total of 110 patients with middle and advanced lung cancer admitted to the oncology department of a hospital in Shanghai from May 2017 to April 2019 were selected as the research objects. According to the double-blind method, they were divided into the combination group and the chemotherapy group, with 55 cases in each group. The chemotherapy group was treated with chemotherapy, and the combination group was treated with CIK based on chemotherapy. The curative effect, immune function level, carcinoembryonic antigen (CEA) and B7H4 protein levels before and after treatment between the two groups were observed. Results The total effective rate of the combined group was higher than that of the chemotherapy group, and the difference was statistically significant (P＜0.05). There were no significant differences in the levels of CD3+, CD4+, CD4+/CD8+, B7H4 protein and CEA between the two groups before treatment (P＞0.05). After treatment, the levels of CD3+, CD4+, CD4+/CD8+ in the combined group were higher than those in the chemotherapy group, while the levels of B7H4 protein and CEA in the combined group were lower than those in the chemotherapy group, and the differences were statistically significant (P＜0.05). Conclusion CIK combined with chemotherapy in the treatment of middle and advanced lung cancer has certain curative effect, which can significantly improve the immune function of patients by down-regulating the level of B7H4 protein. 2020 Vol. 27 (28): 39-42 [Abstract] ( 34 ) HTML (41 KB)  PDF  (0 KB)  ( 10 ) 43 Influencing factors analysis of macroangiopathy in patients with hypertension and type 2 diabetes mellitus and its countermeasures SONG Guo-liang； WAN Zhen-ying； XIE Ying Objective To investigate the influencing factors of macroangiopathy in patients with hypertension and type 2 diabetes mellitus and its countermeasures. Methods The clinical data of 200 patients with hypertension and type 2 diabetes mellitus who were treated in the Third Hospital of Nanchang from November 2018 to November 2019 were retrospectively analyzed, and they were divided into lesion group (n=120) and non-lesion group (n=80) according to the abnormal changes of carotid artery intima. The general data and biochemical indexes of two groups were collected, and the influencing factors of macroangiopathy in patients with hypertension and type 2 diabetes mellitus were analyzed.The lesion group was divided into two groups according to different intervention methods, with 60 cases in each group.Group A was given routine treatment, and group B added lifestyle intervention. The situations of patients before intervention and after intervention for 12 weeks were compared. Results The fasting insulin (FINS), intima-media thickness (IMT), homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment-β cell function (HOMA-βF) in lesion group were higher than those in non-lesion group, with statistically significant differences (P＜0.05). There were no statistical differences in the body mass index (BMI), fasting plasma glucose (FPG)and glycated hemoglobin (HbA1c) between the lesion group and the non-lesion group (P＞0.05). Multivariate Logistic regression analysis found that FINS≥55.50 pmol/L, IMT≥1.10 mm, HOMA-IR≥3.25%, and HOMA-βF≥3.40%were risk factors for macroangiopathy in patients with hypertension and type 2 diabetes mellitus (OR＞1, P＜0.05). After intervention, the levels of FINS and HOMA-IR in group B were lower than those in group A, and the differences were statistically significant(P＜0.05).Conclusion FINS≥55.50 pmol/L, IMT≥1.10 mm, HOMA-IR≥3.25%, and HOMA-βF≥3.40% are risk factors of macroangiopathy in patients with hypertension and type 2 diabetes mellitus. Early treatment and effective lifestyle intervention can improve insulin resistance, and delay the development of macroangiopathy. 2020 Vol. 27 (28): 43-46 [Abstract] ( 30 ) HTML (35 KB)  PDF  (0 KB)  ( 9 ) 47 Application effect of Salvia Polyphenolate in patients with coronary heart disease and angina pectoris CUI Da-wei； MENG Shuai；JIN Ze-ning Objective To investigate the effect of Salvia Polyphenolate on the improvement of angina symptoms and endothelial function in patients with coronary heart disease and angina pectoris. Methods A total of 400 patients with coronary heart disease and angina pectoris treated in Beijing Tiantan Hospital from January to December 2018 were selected as the research subjects. They were divided into the control group (200 cases) and the observation group (200 cases) using the random number table method. The control group was treated with conventional treatment, and the observation group was treated with Salvia Polyphenolate on the basis of conventional treatment. The number of angina pectoris episodes, Nitroglycerin use, angina pectoris induction time, time of ST segment depression 1 mm, electrocardiogram effect, angina pectoris effect, endothelin-1 (ET-1) expression level and endothelial cell particles (EMPs) level were compared between the two groups. Results After treatment, the number of angina pectoris episodes and Nitroglycerin use were lower than those before treatment, and the angina pectoris induction time and time of ST segment depression 1 mm were longer than those before treatment, the differences were statistically significant (P＜0.05). After treatment, the number of angina pectoris episodes and Nitroglycerin use of the observation group were lower than those of the control group, and the angina pectoris induction time and time of ST segment depression 1 mm were longer than those of the control group, the differences were statistically significant (P＜0.05). The total effective rate of electrocardiogram in the observation group was higher than that in the control group, and the difference was statistically significant(P＜0.05). The total effective rate of angina pectoris in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05). The levels of ET-1 expression and EMPs after treatment in the two groups were lower than those before treatment, and the levels of ET-1 expression and EMPs after treatment in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).Conclusion Salvia Polyphenolate has a better effect on improving myocardial function in patients with coronary heart disease and angina pectoris and also has a good inhibitory effect on EMPs. 2020 Vol. 27 (28): 47-50 [Abstract] ( 44 ) HTML (42 KB)  PDF  (0 KB)  ( 8 ) 51 Effect of mitral annuloplasty in the treatment of mitral regurgitation caused by left ventricle enlargement LI Xu-dong； HU Ning-dong； LIU Qiu-hua； LIANG Ji-huan； WAN Hai-xia； XIA Xu Objective To explore the effect of mitral annuloplasty in the treatment of mitral regurgitation caused by left ventricle enlargement. Methods Forty patients with mitral regurgitation caused by left ventricle enlargement treated in cardiothoracic surgery department of our hospital from January 2013 to June 2019 were selected as the research objects and divided into two groups by the random number method. Mitral valve replacement was performed in patients in the control group (n=20), and mitral annuloplasty was performed in patients in the observation group (n=20). The operation curative effect, operation indexes and heart function (left ventricular end-diastolic diameter [LVEDD], left ventricular end-systolic diameter [LVESD], left ventricular ejection fraction [LVEF], the left atrial diameter [LAD] and cardiac function grading) before and after operation were compared between the two groups. Results There were no statistically significant differences in the operative successful rate, the reoperation rate, the incidence rate of complications and the intraoperative or postoperative mortality between the two groups (P＞0.05). The blocking time and the cardiopulmonary bypass time in the observation group were longer than those in the control group, with statistically significant differences (P＜0.05). There were no statistically significant differences in the drainage volume 1 day after the operation and the length of hospital stay between the two groups (P＞0.05). There were no statistically significant differences in the LVEDD, LVESD, LVEF, LAD, cardiac function grading before operation and 6 months after the operation between the observation group and the control group (P＞0.05). In the two groups, LVEDD, LVESD, LAD at 6 months after the operation were smaller than those before operation, the cardiac function grading at 6 months after the operation was lower than that before operation, and LVEF at 6 months after the operation was higher than that before operation, with statistically significant differences (P＜0.05). Conclusion The effect of mitral annuloplasty in the treatment of mitral regurgitation caused by left ventricle enlargement is significant, with high operative successful rate and low incidence rate of complications. It is also able to effectively improve the heart function, correct valve regurgitation, and avoid the long-term anticoagulant treatment needed by the replacement, which has positive clinical significance. 2020 Vol. 27 (28): 51-54 [Abstract] ( 37 ) HTML (36 KB)  PDF  (0 KB)  ( 10 ) 55 Clinical effect of Metoprolol Succinate Sustained-release Tablets in the treatment of dilated cardiomyopathy TIAN Zhi-huan Objective To investigate the clinical effect of Metoprolol Succinate Sustained-release Tablets in the treatment of dilated cardiomyopathy. Methods A total of 74 patients with dilated cardiomyopathy who were admitted to our hospital from April 2018 to April 2019 were selected as the observation objects. According to the random number table method, the patients were divided into the conventional group (n=37, treated with Sacubitril Valsartan Sodium Tablets)and the study group (n=37, treated with Metoprolol Succinate Sustained-release Tablets on the basis of the conventional group). The heart rate (HR), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter(LVESD), and the number of pre-ventricular contractions in 24 h before and after treatment were observed and compared between the two groups and the incidence of arrhythmias and major adverse cardiac events (MACE) was compared between the two groups after 6 months of follow-up. Results After treatment, the HR, LVEDD and LVESD in the study group were lower than those in the conventional group, and the number of pre-ventricular contractions in 24 h in the study group was fewer than that in the conventional group, with statistically significant differences (P＜0.05). Following up for 6 months, the total incidence rates of arrhythmia and MACE in the study group were lower than those in the conventional group, with statistically significant differences (P＜0.05). Conclusion The use of Metoprolol Succinate Sustained-release Tablets in the treatment of dilated cardiomyopathy can effectively reduce the occurrence of arrhythmia, acute heart failure and other adverse events, improve the cardiac function of patients, and improve the long-term efficacy of patients. 2020 Vol. 27 (28): 55-57转61 [Abstract] ( 24 ) HTML (33 KB)  PDF  (0 KB)  ( 5 ) 58 Application of impedance exercise in young patients with coronary heart disease after PCI and its effect on cardiac function and expression of inflammatory factors LUO Li-wen Objective To investigate the application of impedance exercise in young patients with coronary heart disease after percutaneous coronary intervention (PCI) therapy and its effect on cardiac function and expression of inflammatory factors. Methods A total of 40 young coronary heart disease patients received PCI in our hospital from January 2016 to February 2018 were selected as the study objects and divided into the experimental group and the control group by completely random grouping method, with 20 cases in each group. Patients in the experimental group were given impedance exercise on the basis of routine prophylactic medication, while patients in the control group were given routine prophylactic medication. Exercise equivalent (MET), left ventricular ejection fraction (LVEF), peak power(Pp), and interleukin-6 (IL-6), interleukin-10 (IL-10) concentrations were compared at the beginning of the treatment and after 1 year of treatment. Results After 1 year of treatment, the MET, LVEF and Pp of the experimental group were higher than those of the control group, and the differences were statistically significant (P＜0.05). The IL-6 concentration in the experimental group was lower than that of the control group, the IL-10 concentration was higher than that of the control group, and the differences were statistically significant (P＜0.05). Conclusion Impedance exercises can enhance cardiac function of young coronary heart disease patients receiving PCI therapy and reduce inflammatory response, than improve the prognosis of the disease. 2020 Vol. 27 (28): 58-61 [Abstract] ( 33 ) HTML (36 KB)  PDF  (0 KB)  ( 11 ) 62 Expression and role of TDP-43 and LC3 in polymyositis and sporadic inclusion body myositis ZENG Guo-yong；ZENG Xiang-jun；YE Jin Objective To explore the expression and role of TDP-43 and LC3 in polymyositis (PM) and sporadic inclusion body myositis (IBM). Methods From March 2018 to September 2019, the moderately affected muscles of PM（26 cases）and IBM （26 cases） who were admitted to our hospital were selected for biopsy, and the electromyographic puncture points were avoided. The muscle tissue of the PM patients was taken as the PM group, and the muscle tissue of the IBM patients was taken as the IBM group. The differences of TDP-43, LC3 positive expression rate and protein content between PM group and IBM group by immunohistochemistry, Western blot and other methods were analyzed,and then the expression and role of TDP-43, LC3 in PM and IBM was explored. Results The results of immunohistochemistry showed that the positive expression of TDP-43 and LC3 in the muscle tissue of the IBM group was higher than that of the PM group; the results of Western blot showed that the protein contents of TDP-43 and LC3 in the muscle tissue of the IBM group were higher than those of the PM group, the differences were statistically significant (P＜0.05). Conclusion TDP-43 and LC3 are more easily expressed in IBM skeletal muscle specimens, and can be used as one of the indicators for differential diagnosis from PM. 2020 Vol. 27 (28): 62-64 [Abstract] ( 27 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 65 Effect of ultrasonic therapeutic apparatus in the treatment of tension headache HE Bing-rong； YI Yu-jun； XU Bo； ZHU Jing-chun； ZHANG Yu-long Objective To explore the effect of ultrasonic therapeutic apparatus in the treatment of patients with tension headache. Methods A total of sixty patients with tension headache treated in our hospital from June 2018 to March 2020 were selected as the research subjects and divided into the control group and the observation group by random number table method, with 30 cases in each group. The control group received conventional treatment, while the observation group received ultrasound treatment. The headache score, frequency of headache attacks, duration of headache before and after treatment and curative effect of the two groups were compared. Results Before treatment, there were no significant differences in headache score, frequency of headache attacks and duration of headache between the two groups (P＞0.05). After 5 days of treatment, the headache scores of the two groups were lower than those before treatment, the frequencies of headache attacks were less than those before treatment, the duration of headache was shorter than that before treatment, and the differences were statistically significant (P＜0.05). After 5 days of treatment, the headache score of the observation group was lower than that of the control group, the frequency of headache attacks was less than that of the control group, and the duration of headache was shorter than that of the control group, and the differences were statistically significant (P＜0.05). The total effective rate of the observation group (93.33%) was higher than that of the control group (80.00%), and the difference was statistically significant (P＜0.05). Conclusion Ultrasonic therapeutic apparatus can improve the symptoms and shorten the time of symptoms in patients with tension headache. It has a remarkable clinical effect. 2020 Vol. 27 (28): 65-67转74 [Abstract] ( 38 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 68 Clinical study of Aripiprazole combined with Haloperidol Decanoate in the treatment of residual schizophrenia CAI San-jiang； TAN Yuan-hua； JI Ying；ZHANG Guang-ping；ZHANG Bo-cheng Objective To investigate the clinical effect of Aripiprazole combined with Haloperidol Decanoate in the treatment of residual schizophrenia. Methods A total of 50 patients with residual schizophrenia who were treated in our hospital from January 2019 to January 2020 were included in this study. According to the random number table control method, they were divided into two groups, 25 cases in each group. The control group received Aripiprazole Tablets. The patients in the study group received Aripiprazole Tablets combined with Haloperidol Decanoate injection. The changes of PANSS and TESS were compared before and after treatment in the two groups.Results The positive symptom score,negative symptom score, general psychopharmacology score and total score of the two groups at 2, 4, 6 weeks of treatment were lower than those of the same group before treatment, the differences were statistically significant (P＜0.05); the positive symptom score, negative symptom score, general psychopharmacology score and total score of the study group at 2,4, 6 weeks of treatment were lower than those of the control group at the same time, the differences were statistically significant (P＜0.05); the TESS scores of the two groups increased gradually at 2, 4, 6 weeks of treatment, the differences were statistically significant(P＜0.05); there were no significant differences in TESS scores between the two groups(P＞0.05). Conclusion The combination of Aripiprazole and Haloperidol Decanoate can improve the therapeutic effect of residual schizophrenia, and will not significantly increase adverse reactions, which is worthy of clinical recommendation. 2020 Vol. 27 (28): 68-70 [Abstract] ( 40 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 71 Clinical effect of hematoma clearance under keyhole neuroendoscope after precise location of temporal lobe hematoma ZHENG Peng-feng； WEI De Objective To analyze the curative effect of minimally invasive surgery to remove hematoma under keyhole neuroendoscope after precise localization of temporal lobe hematoma. Methods Retrospective analysis was performed on the clinical data of 40 patients with spontaneous temporal lobe hematoma who were admitted to South Branch of Fujian Provincial Hospital from May 2015 to May 2019. They were divided into endoscopic group (20 cases) and traditional group (20 cases) according to different surgical methods. In the endoscopic group, the keyhole without sleeve was used as the working channel after precise positioning, and the hematoma was cleared by minimally invasive surgery under neuroendoscopy. While the traditional group was treated by traditional experiential craniotomy microscope. The operation and prognosis situations at 6 months were compared between the two groups. Results The hematoma clearance rate of the endoscopic group was higher than that of the traditional group, the operative time of the endoscopic group was shorter than that of the traditional group, the intraoperative blood loss of the endoscopic group was less than that of the traditional group, the differences were statistically significant (P＜0.05). The incidence of large area cerebral infarction in the endoscopic group (10.0%) was not significantly different from that in the traditional group (20.0%) (P＞0.05).Comparison of prognosis situation 6 months after operation between the two groups showed no statistically significant difference (P＞0.05). Conclusion For spontaneous temporal lobe hematoma, neuroendoscopic surgery after precise location does not require sleeve as a working channel, which has positive efficacy, safety and less bleeding, and is worthy of promotion. 2020 Vol. 27 (28): 71-74 [Abstract] ( 28 ) HTML (34 KB)  PDF  (0 KB)  ( 12 ) 75 Effect of Edaravone combined with Butylphthalide Soft Capsules in the treatment of cerebral infarction WU Xi Objective To explore the effect of Edaravone and Butylphthalide Soft Capsules in the treatment of cerebral infarction. Methods From January 2018 to June 2019, 100 patients with cerebral infarction treated in our hospital were selected as subjects. They were divided into two groups by simple randomization method, with 50 cases in each group.Control group was treated with Edaravone, experimental group was treated with Edaravone combined with Butylphthalide Soft Capsules. The treatment effect, total incidence of adverse reactions, neurological function scores and blood biochemical index levels of the two groups were analyzed and compared. Results The total effective rate of patients in the experimental group was 94.00%, which was higher than that in the control group (80.00%), the difference was statistically significant (P＜0.05). The neurological function scores, erythrocyte aggregation indexes and whole blood viscosities of the two groups after treatment were all lower than those before treatment, the differences were statistically significant (P＜0.05). The neurological function score, erythrocyte aggregation index and total blood viscosity of the experimental group after treatment were lower than those of the control group, with statistically significant differences (P＜0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05). Conclusion The combined treatment of Edaravone and Butylphthalide Soft Capsules in patients with cerebral infarction can better improve the patients′ condition, which is of great significance. 2020 Vol. 27 (28): 75-77 [Abstract] ( 27 ) HTML (31 KB)  PDF  (0 KB)  ( 13 ) 78 Study on vascular endothelial function, inflammatory factors and clinical effects of ultra-early small bone flap hematoma removal on hypertensive cerebral hemorrhage patients SHANG Cheng-sheng Objective To investigate the vascular endothelial function, inflammatory factors and clinical effects of ultra-early small bone flap hematoma removal on hypertensive cerebral hemorrhage patients. Methods A total of 80 cases hypertensive cerebral hemorrhage patients admitted to our hospital from January 2017 to December 2019 were selected as research objects, and they were divided into two groups according to random number table method, 40 cases in each group. All patients underwent surgical intervention under general anesthesia tracheal intubation. The observation group underwent ultra-early small bone flap cerebral hemorrhage removal, while the control group underwent early small bone flap cerebral hemorrhage removal. The changes of vascular endothelial growth ability, vascular endothelial function and inflammatory factor indexes were compared between the two groups 3 days after treatment. Intracranial pressure and cerebral perfusion pressure were counted 3 days after operation. Results On the 3 days after treatment,the levels of VEGF and bFGF in vascular endothelial growth capacity of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05); ET-1 level in vascular endothelial function index of the observation group was lower than that of the control group, the difference was statistically significant (P＜0.05); NO level of the observation was higher than that of the control group, the difference was statistically significant(P＜0.05); hs-CRP and TNF-α levels in inflammatory factors of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05); intracranial pressure of the observation group was lower than that of the control group,the difference was statistically significant (P＜0.05); and cerebral perfusion pressure of the observation was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion For hypertensive cerebral hemorrhage patients, ultra-early minimally invasive hematoma removal with small bone flap can effectively reduce vascular endothelial function and inflammatory factors in the body, and can also reduce intracranial pressure and increase cerebral perfusion pressure, it helps improve patient prognosis. 2020 Vol. 27 (28): 78-81 [Abstract] ( 29 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 82 Application of good limb placement combined with local vibration training in stroke patients with hemiplegia and its effect on motor function CUI Ting Objective To investigate the application of good limb position combined with local vibration training in patients with hemiplegia after stroke and its effect on motor function. Methods A total of 120 patients with stroke hemiplegia admitted to Liaoyang Central Hospital in Liaoning Province from June 2018 to June 2019 were selected as the research objects and assigned to the control group (n=60) and the study group (n=60) by simple random sampling. Patients in the control group received local vibration training, while patients in the study group received well-limbed placement combined with local vibration training, both groups were nursed for 8 weeks. The clinical efficacy, limb function evaluation, daily living ability and complications of patients of the two groups after nursing were compared between the two groups. Results After nursing, the effective rate of treatment in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05); there were no statistically significant differences in simplified fugl-meyer scale (FMA) score and Barthel index (BI) scale score before nursing care between the two groups (P＞0.05); after nursing, FMA score and BI score in the two groups were higher than those before nursing,the differences were statistically significant(P＜0.05); in addition, FMA score and BI score of the study group after nursing were higher than those of the control group, with statistically significant differences (P＜0.05); after nursing, the total incidence of complications in the study group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion The combination of good limb position and local vibration training for hemiplegia patients with stroke has a good clinical effect. 2020 Vol. 27 (28): 82-84 [Abstract] ( 24 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 85 Effect comparison of flexible ureteroscopic holmium laser in the treatment of different sizes of kidney stones WU Hua-jun； WU Jun； YU Kai-ye； HE Yu Objective To compare the clinical efficacy of flexible ureteroscopic holmium laser lithotripsy (FURS) in treatment of different sizes of kidney stones. Methods The clinical data of 60 patients with kidney stones who admitted in our hospital from January 2018 to September 2019 were retrospectively analyzed and divided into small stone group(stone diameter ≤2 cm) and large stone group (stone diameter ＞2 cm) according to the size of the stones, with 30 cases in each group. The patients in two groups were treated with FURS. The surgical indexes, stone clearance rate, the quality of life and the incidence of postoperative complications were compared between the two groups. Results There were no statistically significant differences in the intraoperative bleeding volume and decreased value of hemoglobin between the two groups (P＞0.05). The operation time, hospital stays time and postoperative removing stone time in large stone group were longer than those in small stone group, and the differences were statistically significant (P＜0.05). There were no statistical differences in the stone clearance rate and the incidence of postoperative complications between the two groups (P＞0.05). There was no statistically significant difference in the generic quality of life inventory (GQOLI-74)score before and 1 month after surgery between the two groups (P＞0.05). The GQOLI-74 scores 1 month after surgery in two groups were higher than those before surgery, and the differences were statistically significant (P＜0.05). Conclusion FURS in treatment of kidney stones ＞2 cm or ≤2 cm has higher stone clearance rates, it can significantly increase quality of life of patients, and it has advantages of high safety, small trauma and less complications, which has better curative effects for small stones and higher safety. 2020 Vol. 27 (28): 85-87转91 [Abstract] ( 27 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 88 Application of flexible ureteroscope sheath in transurethral hard-lens ureteral holmium laser lithotripsy for treatment of large ureteral calculi ZHU Zheng-bin； LUO Jian-bin； YUAN Guo-ming Objective To explore the application effect of flexible ureteroscope sheath in transurethral hard-lens ureteral holmium laser lithotripsy for treatment of large ureteral calculi. Methods The clinical data of 60 patients with large ureteral calculi admitted to our hospital from November 2018 to October 2019 were analyzed retrospectively and divided into the control group and the experimental group according to different surgical methods, with 30 cases in each group. The patients in the control group were treated by transurethral holmium laser under ureteroscope, while the patients in the experimental group were treated by flexible ureteroscope sheath in transurethral hard-lens ureteral holmium laser lithotripsy. The operation time, stone clearing rates, the incidence of ureteral injury, the total incidence of postoperative complications, and the levels of serum creatinine and hemoglobin before and after treatment of the two groups were compared. Results The operation time of the experimental group was shorter than that of the control group,the stone clearing rate was higher than that of the control group, the incidence of ureteral injury and the total incidence of postoperative complications were lower than those of the control group, and the differences were statistically significant (P＜0.05). There were no statistically significant difference in the level of serum creatinine and hemoglobin between the two groups before and after treatment (P＞0.05). Conclusion The application of flexible ureteroscope sheath in transurethral hard-lens ureteral holmium laser lithotripsy for treatment of large ureteral calculi obtains a remarkable clinical effect. 2020 Vol. 27 (28): 88-91 [Abstract] ( 25 ) HTML (35 KB)  PDF  (0 KB)  ( 10 ) 92 Effect comparison of microscopic varicocele ligation and laparoscopic varicocele high ligation in the treatment of primary varicocele JIANG Qi-qi； YE Lie-fu； WU Jin-feng； LIU Zhi-hua； CHEN Song-mao Objective To compare the effect of microscopic varicocele ligation and laparoscopic varicocele high ligation in the treatment of primary varicocele. Methods The clinical data of 90 patients with primary varicocele admitted to the Department of Urology of Fujian Provincial Hospital and Fujian Provincial Jinshan Hospital from January 2015 to June 2018 were retrospectively analyzed. According to the operation method, they were divided into the microscope group (48 cases) and the laparoscopic group (42 cases). The microscope group was treated with microscopic varicocele ligation, the laparoscopic group was treated with laparoscopic varicocele high ligation. The operation time, blood loss,testicular artery recognition rate, hospitalization time, postoperative complications and varicose recurrence were compared between the two groups. Results The operation time of the microscope group was longer than that of the laparoscopic group, the difference was statistically significant (P＜0.001). The recognition rate of testicular artery in the microscope group was higher than that in the laparoscopic group, the difference was statistically significant (P=0.007). The intraoperative blood loss of the microscope group was less than that of the laparoscopic group, the difference was statistically significant (P＜0.001). There was no significant difference in the hospitalization time between the two groups (P=0.609). The scrotal edema, testicular atrophy in 2 years after operation and recurrence rate in 2 years after operation in the microscope group were lower than those in the laparoscopic group, the differences were statistically significant (P＜0.05). Conclusion The curative effect of microscopic varicocele ligation is better than that of laparoscopic varicocele high ligation. 2020 Vol. 27 (28): 92-94转98 [Abstract] ( 21 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 95 Clinical effect of blood purification in the treatment of renal failure with acute heart failure YU Yu；YU Mu-sheng； LI Nan-jie；LIU Miao-ru Objective To investigate the clinical effect of blood purification therapy in patients with renal failure and acute heart failure. Methods A total of 80 patients with renal failure and acute heart failure admitted to our hospital from January 2018 to April 2019 were selected as the research objects and divided into the control group and the experimental group according to the randomized double-blind method, with 40 cases in each group. The control group received routine emergency treatment, while the experimental group received blood purification treatment on the basis of the control group. The treatment effect, acute physiology and chronic health evaluation (APACHE-Ⅱ) scores, left ventricular ejection fractions, cardiac outputs and renal functions of the two groups were compared. Results The total effective rate of the experimental group (97.50%) was higher than that of the control group (77.50%), and the difference was statistically significant (P＜0.05). The APACHE-Ⅱscores of the two groups after treatment were lower than those before treatment, the left ventricular ejection fractions and cardiac outputs were higher than those before treatment, and the differences were statistically significant (P＜0.05). The APACHE-Ⅱscore of the experimental group after treatment was lower than that of the control group, the ventricular ejection fraction and cardiac output were lower than those of the control group, and the differences were statistically significant (P＜0.05). The levels of blood urea nitrogen (BUN)andserum creatinine (Scr) in two groups after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05). The levels of BUN and Scr in the experimental group after treatment were lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Blood purification treatment on patients with renal failure and acute heart failure can obtain better results, improve the patients′ heart function and renal function. 2020 Vol. 27 (28): 95-98 [Abstract] ( 19 ) HTML (35 KB)  PDF  (0 KB)  ( 10 ) 99 Application and clinical effect observation of three lumen tube in total laryngectomy CAO Bing； JIAO Na； CHEN Ting-hui ；WANG Yue-wu； ZHANG Xiao-an； LAI Wen-min Objective To investigate the application effect of three lumen tube in patients undergoing total laryngectomy. Methods A total of 64 cases of total laryngectomy patients admitted to our hospital from September 2017 to October 2019 were selected as the observation objects. According to the control principle, they were randomly divided into the control group (n=32) and the observation group (n=32). The control group used conventional drainage tube, the observation group used three lumen tube. The total clinical satisfaction, total incidence of adverse events, wound healing time and hospital stay were compared between the two groups. Results The total clinical satisfaction of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The wound healing time and hospital stay in the observation group were shorter than those in the control group, with statistically significant differences (P＜0.05). Conclusion The application of three lumen tube in total laryngectomy can effectively improve the clinical symptoms of patients, improve patient satisfaction, shorten the healing time of incision, and promote the early discharge of patients. 2020 Vol. 27 (28): 99-101 [Abstract] ( 20 ) HTML (31 KB)  PDF  (0 KB)  ( 11 ) 102 Effect of intraoperative saline irrigation incision on preventing fat liquefaction LI Zhen-sheng； ZHOU Ge；CHEN Ruo-bing Objective To observe the effect of intraoperative saline irrigation incision to prevent fat liquefaction and infection in abdominal obese patients. Methods A total of 498 patients with abdominal obesity who needed abdominal surgery in Liaoyang Central Hospital from January 2016 to December 2018 were selected, and they were randomly divided into the saline washing group (248 cases) and the routine treatment group (250 cases) according to the order of treatment. In the saline washing group, after suturing the abdominal wall, the incision was rinsed with saline to remove the fat debris until it was clean, then sutured after sterile gauze suctioned cleanly saline. In the routine treatment group, routine suture was performed. The wound healing grade and cycle, fat liquefaction rate and infection rate in the two group after operation were observed. Results The grade of wound healing in the saline washing group was better than that in the routine treatment group, there was significant difference (P＜0.05). The wound healing cycle of the saline washing group was shorter than that of the routine treatment group, and the fat liquefaction rate and infection rate of the saline washing group were lower than those of the routine treatment group, there were significant differences(P＜0.05). Conclusion Intraoperative saline washing can promote incision healing and shorten the incision healing period in abdominal obese patients, reducing incision fat liquefaction rate and infection rate. 2020 Vol. 27 (28): 102-105 [Abstract] ( 22 ) HTML (39 KB)  PDF  (0 KB)  ( 9 ) 106 Clinical application value of transoral vestibular surgery treatment in patients with large-size benign thyroid tumors SHEN Wen-hua； DING Ji-wei； LIU Yan-zhang Objective To study and analyze the clinical application value of transoral vestibular surgery treatment in patients with large-size benign thyroid tumors. Methods A total of 80 patients with large-size benign thyroid tumors admitted in our hospital from October 2017 to November 2019 were selected as the research subjects. They were divided into the control group (n=40) and the study group (n=40) according to block randomization. The patients in the control group were treated with total areola approach endoscopic surgery, and the patients in the study group were treated with transoral vestibular surgery. The routine operation indexes, the total incidence of postoperative complications and patients′ total satisfaction with the operation results were compared between the two groups. Results The operation time of the study group was (94.26±26.74) min, which was shorter than that of the control group of (131.05±39.73) min, the difference was statistically significant (P＜0.05). There were no significant differences in in intraoperative blood loss and hospital stay between the two groups (P＞0.05). The total incidence of complications in the study group was 1.18%,which was lower than that of the control group (8.24%), the patients′ total satisfaction of the study group was 97.65%,which was higher than that of the control group (88.24%), the difference was statistically significant (P＜0.05). Conclusion Under the conditions of surgical safety, transoral vestibular surgery can further shorten the operation time, help the control of the disease, reduce the probability of postoperative complications, and the postoperative cosmetic effect is better, and the patients are more satisfied with the results of the operation. 2020 Vol. 27 (28): 106-109 [Abstract] ( 20 ) HTML (34 KB)  PDF  (0 KB)  ( 11 ) 110 Clinical effect of endovenous laser therapy combined with Chuangyang Waixi Decoction in the treatment of venous ulcer ZHANG Lei； CAI Mei-qin；ZHANG Yuan-yuan；XU Xin-gang Objective To investigate the clinical effect of endovenous laser therapy combined with Chuangyang Waixi Decoction in the treatment of venous ulcer. Methods A total of 80 patients with venous ulcer who admitted in our hospital from January to December 2019 were selected as the reseach objects, and they were divided into the control group(n=40) and the observation group (n=40) according to random number table method. The control group was given endovenous laser therapy, and the observation group was treated with Chuangyang Waixi Decoction based on the control group. The disappearance time of clinical symptoms and the adverse reactions during treatment were compared between the two groups. Results The disappearance time of superficial varicose veins, edema, hyperpigmentation and eczematoid reaction in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). The total incidence of adverse reactions in the observation group (5.00%) was lower than that in the control group (20.00%), and the difference was statistically significant (P＜0.05). Conclusion Endovenous laser therapy combined with Chuangyang Waixi decoction in the treatment of venous ulcer can relieve clinical symptoms and have higher safety. 2020 Vol. 27 (28): 110-112 [Abstract] ( 21 ) HTML (33 KB)  PDF  (0 KB)  ( 9 ) 113 Application of artificial pneumothorax assisted with single-port thoracoscopic thymectomy in patients with thymic tumors XIE Jin-bao； DU Quan； LIN Min； TU Yuan-rong； CHEN Jian-feng Objective To investigate the application of artificial pneumothorax assisted with single-port thoracoscopic thymectomy in patients with thymic tumors. Methods From September 2016 to December 2018, a total of 28 patients with thymic tumor underwent artificial pneumothorax assisted with single-port thoracoscopic thymectomy were selected as the experimental group, and a total of 38 patients with thymic tumor who underwent artificial pneumothorax assisted thoracoscopic (three hole) thymectomy in the same period were selected as the control group. The experimental group was treated with artificial pneumothorax assisted with single-port thoracoscopic thymectomy, while the control group was treated with artificial pneumothorax assisted thoracoscopic (three hole) thymectomy. The operation time,intraoperative blood loss, postoperative drainage volume and postoperative hospital stay were compared between the two groups. Results There were no significant differences in operation time, intraoperative blood loss, postoperative hospital stay, postoperative chest tube placement time, pathological type and the proportion of 26F drainage tube between the two groups (P＞0.05). The visual analogue pain score of the experimental group at 24 h after operation was lower than that of the control group, and the difference was statistically significant (P＜0.05). Both groups recovered well after operation, without complications or perioperative death, and there was no recurrence after 6 to 18 months follow-up.Conclusion Artificial pneumothorax assisted with singl-port thoracoscopic thymectomy is feasible and safe for patients with thymic tumor. 2020 Vol. 27 (28): 113-116 [Abstract] ( 22 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 117 Application of electrocoagulation hook combined with thread ligation in laparoscopic appendectomy WU Gui-jian； ZHONG Ming-cheng； QIU Guo-huang Objective To analyze the effect, safety and economy of electrocoagulation hook combined with thread ligation to treat mesangial appendix and stump in laparoscopic appendectomy. Methods A total of 300 patients with acute and chronic appendicitis from January 2016 to December 2019 in our hospital were selected as the research objects.They were divided into the treatment group (150 cases) and the control group (150 cases) by using random number table method. The laparoscopic appendectomy surgery for appendix mesentery and stump was carried out in the treatment group by electrocoagulation hook combined with thread ligation. While in the control group, the mesenteric appendage was cut off by ultrasonic scalpel with Hem-o-lok clip or disposable wire ligation laparoscopic appendectomy surgery for appendage stumps. The various surgical indexes and incidence of postoperative complications were compared between the two groups. Results The operation time of the treatment group was longer than that of the control group, and the cost of hospitalization was lower than that of the control group, and the differences were statistically significant (P＜0.05). There were no statistically significant differences in the intraoperative blood loss, length of hospitalized and total incidence of postoperative complications between the two groups (P＞0.05). Conclusion During the treatment of electrocoagulation hook combined with thread ligation for appendix mesentery and stump compared with ultrasonic scalpel to remove the appendix mesentery with Hem-o-lok clip or disposable ligation laparoscopic appendectomy,the application of the two resections has advantages of definite curative effect and safety. However, the former has better advantage of low cost, which is worthy of wide use in clinical promotion, especially in primary hospitals. 2020 Vol. 27 (28): 117-120 [Abstract] ( 20 ) HTML (39 KB)  PDF  (0 KB)  ( 14 ) 121 Clinical effect of Xiaozhiling combined with prolapse and hemorrhoids in the treatment of rectal intramucosal prolapse LIU Jia； CAI Ming-zhu Objective To investigate the clinical effect of Xiaozhiling combined with prolapse and hemorrhoids (PPH)in the treatment of rectal intramucosal prolapse. Methods A total of 80 patients with rectal intramucosal prolapse admitted to our hospital from August 2017 to October 2019 were selected as the research objects. According to the method of random number table, they were divided into the control group (40 cases) and the observation group (40 cases). The observation group was treated with PPH alone, the observation group was treated with Xiaozhiling on this basis. The symptom score, operation time, hospitalization time and postoperative complications of the two groups were compared. Results There were no significant differences in the preoperative and postoperative symptom score of the 1th,3th days, operation time and hospitalization time between the two groups (P＞0.05). There were no significant differences in the incidence of anal pain, anal distention and dysuria between the two groups (P＞0.05). The incidence rate of postoperative bleeding in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Compared with PPH alone, Xiaozhiling combined with PPH has less postoperative bleeding and higher safety in clinical application. 2020 Vol. 27 (28): 121-123 [Abstract] ( 24 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 124 Application effect of Taohong Siwu Decoction on early avascular necrosis of femoral head after core decompression bone grafting ZHANG Min；PENG Jing； WEI Ming； ZHANG Qiang Objective To explore the clinical effect of Taohong Siwu Decoction on early avascular necrosis of femoral head after core decompression bone grafting. Methods A total of 60 patients with early avascular necrosis of femoral head who admitted in our hospital from January 2016 to may 2017 were selected as the study objects and divided into the study group and the control group according to the random number table method, with 30 cases in each group. The research group was treated with Taohong Siwu Decoction after core decompression bone grafting. The control group was treated with core decompression bone grafting. The clinical effect, hip joint functions and iconography evaluation of the two groups were compared. Results The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant (P＜0.05). The hip Harris function scores of the study group at 3, 6, 12,24 months after operation were higher than those of the control group, and the differences were statistically significant(P＜0.05). The iconography evaluation of the study group 6 months after operation was better than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The application of Taohong Siwu Decoction in early avascular necrosis of femoral head after core decompression bone grafting can effectively improve the hip joint function of patients, speed up recovery, and the effect is remarkable. It is worthy of promotion and application. 2020 Vol. 27 (28): 124-126转130 [Abstract] ( 25 ) HTML (35 KB)  PDF  (0 KB)  ( 10 ) 127 Clinical effect of intra-articular injection of Sodium Hyaluronate in patients with knee osteoarthritis LI Jin； RAO Hai-jun； LIN Xue-yang； YANG Jian-hua Objective To explore the clinical effect of intra-articular injection of Sodium Hyaluronate in patients with knee osteoarthritis. Methods A total of 107 patients with knee osteoarthritis admitted to our hospital from January 2018 to December 2019 were selected as subjects and divided into the experimental group (57 cases) and the control group(50 cases) by random lottery method. The experimental group was given intra-articular injection of Sodium Hyaluronate,the control group was given oral Glucosamine Hydrochloride Capsules. The severity of the disease, Western Ontario and McMaster University (WOMAC) osteoarthritis index score, the synovial thickness, the level of venous tumor necrosis factor-α (TNF-α), the visual analogue scale (VAS) pain score and the efficacy of the treatment were compared between the two groups. Results There were no statistically significant differences in severity of disease, WOMAC osteoarthritis index score, the synovial thickness, the level of venous TNF-α and VAS score between the two groups before and after treatment (P＞0.05). After treatment, the severity of disease, WOMAC osteoarthritis index score, the synovial thickness,the level of venous TNF-α and VAS score of experimental group were lower than those of the control group, and the differences were statistically significant (P＜0.05). The severity of disease, WOMAC osteoarthritis index score, the synovial thickness, the level of venous TNF-α and VAS score of the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05). The total effective rate in the experimental group (94.74%) was higher than that in the control group (82.00%), and the difference was statistically significant (P＜0.01). Conclusion Intra-articular injection of Sodium Hyaluronate can obviously improve the symptoms of patients with knee osteoarthritis, alleviate the severity of disease, reduce pain, inflammation reaction and the thickness of synovial and has a good therapeutic effect. 2020 Vol. 27 (28): 127-130 [Abstract] ( 19 ) HTML (32 KB)  PDF  (0 KB)  ( 10 ) 131 Application effect of diversified nursing rehabilitation exercise in patients with tibia plateau fracture YANG Fan Objective To analyze the application effect of diversified nursing rehabilitation exercise in patients with tibia plateau fracture. Methods A total of 58 patients with tibia plateau fracture treated in our hospital from January 2018 to December 2019 were selected as the research subjects and divided into the routine group and the intervention group by the random number table method, with 29 cases in each group. The routine group received conventional nursing methods while the intervention group received the diversified nursing rehabilitation exercise. The knee function,total incidence of complications and total nursing satisfaction of patients were compared between the two groups. Results After interference, the knee function score of the intervention group was higher than that of the routine group, and the difference was statistically significant (P＜0.05). The total incidence of complications in the intervention group was lower than that of the routine group, and the difference was statistically significant (P＜0.05). The total nursing satisfaction of the intervention group was higher than that of the routine group, and the difference was statistically significant(P＜0.05). Conclusion Diversified nursing rehabilitation exercise for patients with tibia plateau fracture can significantly improve the knee function of the patients, and reduce the total incidence of complications after treatment, and improve the degree of patient recognition of the nursing staff. 2020 Vol. 27 (28): 131-133 [Abstract] ( 24 ) HTML (31 KB)  PDF  (0 KB)  ( 10 ) 134 Short-term clinical effect comparison of total knee arthroplasty and unicompartmental knee arthroplasty in the treatment of old patients with knee joint unicompartmental osteoarthritis KUANG Zhi-cong； XU Jin-yu； GUAN Tian-yu； JIANG Liang； LIANG Yong-hao； LUO Li-dian Objective To compare the short-term clinical effect of total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) in the treatment of old patients with knee joint unicompartmental osteoarthritis. Methods A total of 60 cases of elderly patients with knee joint unicompartmental osteoarthritis in our hospital from January 2018 to January 2020 were retrospectively analyzed. According to the operation methods, they were divided into TKA group (n=30) and UKA group (n=30). The visual analogue score (VAS), knee mobility (ROM), Western Ontario and McMaster Arthritis Index (WOMAC), American Special Surgery Hospital (HSS) scores and clinical effect of the two groups were statistically analyzed. Results After operation,the VAS score and WOMAC score of the two groups were lower than those before operation, the differences were statistically significant (P＜0.05), ROM and HSS scores were higher than those before operation, the differences were statistically significant(P＜0.05); before and after operation, the VAS score, ROM,WOMAC score and HSS score of the two groups were not statistically significant (P＞0.05). In terms of excellent and good rate of knee joint function recovery, TKA group was 90.0% (45/30), UKA group was 93.3% (46/30), the difference between the two groups was not significant (P＞0.05). Conclusion TKA and UKA have the same clinical effect in the treatment of knee joint unicompartmental osteoarthritis in the elderly. 2020 Vol. 27 (28): 134-136 [Abstract] ( 23 ) HTML (31 KB)  PDF  (0 KB)  ( 12 ) 137 Application of closed reduction and percutaneous hollow screw fixation in ankle fracture LIU Zheng-yu； CUI Jun Objective To explore the application value of closed reduction and percutaneous hollow screw internal fixation in ankle fracture. Methods A total of 80 cases with ankle fracture admitted to our hospital from March 2018 to March 2019 were divided into two groups by the random number table method, with 40 cases in each group. The control group received routine open reduction and internal fixation, while the observation group received closed reduction and percutaneous hollow screw internal fixation. The outpatient follow-up period was 1 year, and the clinical indexes of fracture healing, the changes of American Ankle Association (AOFAS) scores, the complications were compared between the two groups. Results The X-ray healing time of fracture in the observation group was shorter than that in the control group, the difference was statistically significant (P＜0.05); and the walking time and active load-bearing activity time of abandoned crutches in the observation group were shorter than those in the control group, the differences were statistically significant (P＜0.05); the AOFAS score in the observation group was higher than that in the control group 3 months and 1 year after operation, the differences were statistically significant (P＜0.05); the total proportion of incision infection, chronic joint pain, joint stiffness and internal fixation loosening in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion For ankle fractures, closed reduction and percutaneous hollow screw internal fixation can effectively promote postoperative fracture healing of patients,promote early postoperative ambulation and load-bearing activities, improve ankle function, and have fewer complications and high safety. 2020 Vol. 27 (28): 137-139 [Abstract] ( 25 ) HTML (34 KB)  PDF  (0 KB)  ( 9 ) 140 Effect comparison of Super PATH minimally invasive hip replacement and conventional hip replacement in the treatment of elderly femoral neck fractures LI Jing-yu； LU Jian-qi； CAI Zhong-bin； QIAO Ju-feng Objective To compare the effect of Super PATH minimally invasive hip replacement and conventional hip replacement in the treatment of elderly femoral neck fractures. Methods A total of 54 elderly patients with femoral neck fractures admitted to our hospital from August 2016 to August 2019 were divided into the control group (n=27)and the study group (n=27) according to the random number table method. The control group underwent conventional hip arthroplasty. The study group underwent Super PATH minimally invasive hip replacement. The intraoperative indicators, postoperative pain, and hip function scores of patients of the two groups were observed. Results The operation time of the study group was longer than that of the control group, and the difference was statistically significant (P＜0.05); the length of the surgical incision was shorter than that of the control group, and the difference was statistically significant (P＜0.05); the intraoperative blood loss and postoperative pain score were lower than those of the control group, the differences were statistically significant (P＜0.05); the hip function score of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Super PATH minimally invasive hip replacement has certain advantages in reducing intraoperative blood loss, relieving postoperative pain, reducing wounds, and better improving hip function. The disadvantage is that it lengthens the operation time. 2020 Vol. 27 (28): 140-142转146 [Abstract] ( 22 ) HTML (34 KB)  PDF  (0 KB)  ( 9 ) 143 Influence of hypothyroidism screening on pregnancy outcome before and during pregnancy LI Sheng-rong；HUANG Jin-qiu； LI Qin Objective To explore the effect of hypothyroidism screening on pregnancy outcome before and during pregnancy. Methods The clinical data of 300 women before and during pregnancy in Maternal and Child Health Hospital of Ruijin City from July 2017 to November 2019 were selected for retrospective analysis, 150 women who did not participate in the hypothyroidism screening were selected as the control group, and 150 women who participate in the hypothyroidism screening were selected as the observation group. The incidence of adverse pregnancy, hypothyroidism and fetal growth restriction between the two groups were compared. Results The test results of 300 women before and during pregnancy showed that there were 37 cases of hypothyroidism, and the incidence was 12.33%. The incidence of hypothyroidism in the observation group was 11.33%, while that in the control group was 13.33%, there was no significant difference in the incidence of hypothyroidism between the two groups (P＞0.05). The rate of fetal growth restriction in the observation group (1.33%) was lower than that in the control group (6.00%), the difference was statistically significant (P＜0.05). The total incidence of adverse pregnancy outcomes as abortion, premature delivery, pregnancy induced hypertension syndrome, placental abruption and low birth weight infants in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion The screening of hypothyroidism before and during pregnancy can effectively improve the pregnancy outcome and promote the normal development of fetus, which is worthy of promotion. 2020 Vol. 27 (28): 143-146 [Abstract] ( 22 ) HTML (36 KB)  PDF  (0 KB)  ( 8 ) 147 Comprehensive management of iron-deficiency anemia during pregnancy WANG Xin-jiang； HU Xiao-hong； HUANG Qin； HUANG Xiao-yun Objective To explore the effect of comprehensive management of iron-deficiency anemia during pregnancy.Methods A total of 198 cases of iron-deficiency anemia patients during pregnancy who were treated in our hospital from January 2017 to September 2019 were selected as the research subjects. They were divided into two groups according to the random number table method, with 99 cases in each group. In control group, medication for anemia was used if the measurements of ferritin and hemoglobin levels being lower than the normal range during the same period.In observation group, on the basis of the control group, comprehensive management was carried out during pregnancy.The changes of serum ferritin and hemoglobin levels during pregnancy in the two groups were observed, the cesarean section rate, postpartum hemorrhage rate and birth rate of macrosomia were also observed. Results After intervention,the serum ferritin level in the observation group was higher than before intervention and the control group, and the hemoglobin level was higher than before intervention and the control group, the differences were statistically significant(P＜0.05). The cesarean section rate, postpartum hemorrhage rate and birth rate of macrosomia in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion The comprehensive management of iron-deficiency anemia during pregnancy has obvious effects, which can increase the serum ferritin and hemoglobin levels of pregnant women, and reduce the incidence of cesarean section, postpartum hemorrhage and the birth of macrosomia. 2020 Vol. 27 (28): 147-149转153 [Abstract] ( 24 ) HTML (37 KB)  PDF  (0 KB)  ( 13 ) 150 Clinical effect of Methylprednisolone combined with Azithromycin in the treatment of children with Mycoplasma pneumoniae infectious lobar pneumonia WANG Yan； HUANG Ya-ling Objective To explore the clinical effect of Methylprednisolone combined with Azithromycin in the treatment of children with Mycoplasma pneumoniae infectious lobar pneumonia. Methods The clinical data of 86 children with Mycoplasma pneumoniae infectious lobar pneumonia in our hospital from October 2017 to October 2018 were selected,they were divided into control group and observation group according to the treatment plan, 43 cases in each group.The control group was treated with Azithromycin, the observation group was treated with Methylprednisolone and Azithromycin. The efficacy, hospitalization time, symptom recovery time (absorption of lung shadows, disappearance of lung rales and and antipyretic) between the two groups were compared, and lung function (peak expiratory flow rate[PEF], forced vital capacity [FVC], forced expiratory volume in the first second [FEV1]) and inflammatory state (serum C-reactive protein [CRP], interleukin-8 [IL-8], interleukin-6 [IL-6]) before treatment and two weeks after treatment between the two groups were compared. Results The total effective rate in the observation group was 97.67%, which was higher than that in the control group of 81.40%, the difference was statistically significant (P＜0.05). The hospitalization time, lung shadow absorption time, lung rales disappearance time and antipyretic time in the observation group were shorter than those in the control group, the differences were statistically significant (P＜0.05). After two weeks of treatment, the levels of PEF, FVC and FEV1 in the observation group were higher than those in the control group, and the levels of serum CRP, IL-8 and IL-6 in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion The combination of Methylprednisolone and Azithromycin has a significant effect on Mycoplasma pneumoniae infectious lobar pneumonia, which can shorten the recovery time of symptoms and hospitalization time, improve lung function of the children, and reduce the inflammation state. 2020 Vol. 27 (28): 150-153 [Abstract] ( 21 ) HTML (36 KB)  PDF  (0 KB)  ( 10 ) 154 Application of high intensity focused ultrasound combined with hysteroscopic curettage in scar pregnancy after cesarean section BAO Ling-mei； YE Gui-hua Objective To explore the clinical application value of high intensity focused ultrasound combined with hysteroscopic curettage in scar pregnancy after cesarean section. Methods A total of 80 cases with scar pregnancy termination after cesarean section admitted in our hospital from January 2018 to December 2019 were selected as the research objects, they were divided into two groups according to the random number table method, with 40 cases in each group. The observation group received high intensity focused ultrasound intervention, the control group received uterine artery embolization, all received hysteroscopic curettage treatment after surgery. Follow up for 3 months, the postoperative recovery and complications in the two groups were compared, the ratio and time of serum human chorionic gonadotropin (hCG) turning negative during follow-up were compared. Results The postoperative hemorrhage in the observation group was less than that in the control group, the time of get out of bed was earlier than that in the control group, the time of hospitalization was shorter than that in the control group, the differences were statistically significant(P＜0.05). The total incidence of postoperative complications in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The proportion of serum hCG turning negative at all time points during the follow-up period (2 weeks after surgery, 1 month after surgery and 3 months after surgery) in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). The seroconversion rates of hCG at 1 and 3 months after operation in both groups were higher than those at 2 weeks after operation, the differences were statistically significant (P＜0.05). The time of serum hCG turning negative in the observation group was earlier than that in the control group, the difference was statistically significant (P＜0.05). Conclusion For scar pregnancy after cesarean section, high intensity focused ultrasound intervention followed by hysteroscopic curettage treatment can effectively reduce iatrogenic operation injuries, promote early recovery of patients, and have fewer complications and reliable results. 2020 Vol. 27 (28): 154-156 [Abstract] ( 22 ) HTML (33 KB)  PDF  (0 KB)  ( 15 ) 157 Application study of absorbable internal retainer in bone valve reset in the brain injury surgery of children HUANG Chen-ming； ZHOU Xi-han； HUANG Rui-hong； LI Wen-sheng； XIAO Lian-fu；LIN Jin-ping Objective To discusse the application effect of absorbable internal retainer in bone valve reset in the brain injury surgery of children. Methods Retrospective analysis was made on the clinical data of 63 patients with craniofacial brain injury from October 2015 to March 2019 undergoing surgical treatment of bone valve reset fixed, they were divided into study group (31 cases) and control group (32 cases) according to the different cranial reset fixed materials.The bone flap reset was fixed using the retaining body (square head screw and straight bone plate 4 holes) which could be absorbed in the fracture in the study group, and the bone flap reset was fixed using the 2.0 mm bone plate and 2.0 mm×5 mm titanium nail in the control group.The operative time, the total incidence of postoperative complications,the satisfaction of skull shape, the influence of postoperative imaging examination and the absorption of fixed materials were compared between the two groups. Results There were no significant differences in operation time, total incidence of postoperative complications and satisfaction of skull shape between the two groups (P＞0.05). There was no artifact interference in postoperative CT, MRI, and X-ray imaging examinations in the study group, while the control group had clear metal artifact interference in postoperative CT, MRI, and X-ray imaging examinations; the fixation material in the study group was absorbed 8 to 18 months after surgery, and the metal plate in the control group had no absorption in the follow-up. Conclusion In the reduction and fixation of the bone flap during the operation of children with brain injury, there are no significant differences between the absorbable fracture internal fixation body and the metal fixation material in operation time, total incidence of postoperative complications and satisfaction with shaping. The fixation material can be completely absorbed after internal fixation of absorbable fractures, and it has no artifact interference to imaging examination, avoids carrying metal foreign bodies throughout the life, and is beneficial to the normal growth and development of children. 2020 Vol. 27 (28): 157-159 [Abstract] ( 22 ) HTML (33 KB)  PDF  (0 KB)  ( 10 ) 160 Clinical effect of laparoscopic treatment of ectopic pregnancy and its influence on the pregnancy rate of patients CHEN Chuang Objective To explore the clinical effect of laparoscopic treatment of ectopic pregnancy and its influence on the pregnancy rate of patients. Methods A total of 90 patients with ectopic pregnancy who were treated in our hospital from December 2017 to May 2019 were selected as the research objects, and they were divided into study group (n=45)and control group (n=45) according to the random number table method. The control group received open surgery, the study group received laparoscopic surgery. The operative condition and postoperative recovery of the two groups were recorded, and the fallopian tube recanalization and postoperative pregnancy between the two groups were compared.Results The operation time, postoperative exhaust time, time to get out of bed and hospitalization time in the study group were shorter than those in the control group, the differences were statistically significant (P＜0.05). The rate of fallopian tube recanalization in the study group was higher than that in the control group, the difference was statistically significant (P＜0.05). The postoperative pregnancy in the study group was better than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Laparoscopic treatment of ectopic pregnancy can significantly shorten the treatment time, promote early the recovery of patients, improve the rate of postoperative pregnancy, worthy of clinical promotion. 2020 Vol. 27 (28): 160-162转174 [Abstract] ( 24 ) HTML (36 KB)  PDF  (0 KB)  ( 8 ) 163 Establishment of nutrition support team and the research on the intervention effect of Alanyl-glutamine Injection in our hospital SONG Xiao-bing； WU Qing-Rong； WU Qi-Ming； LIU Jian-ping； YAN Hui-fang； XIAO Qing-yu Objective To explore the role and effect of establishing the nutrition support team to intervene Alanyl-glutamine (Ala-Gln). Methods The nutrition support team collected and analyzed case data from July 1st to December 31st 2016 according to the evaluation criteria, as the before intervention; the intervention was carried out from January 1st to June 31st 2017 to address the corresponding problems, as the after intervention. The use of Ala-Gln Injection by clinical departments before and after intervention, the consumption amount and proportion of Ala-Gln Injection, and the rational use of Ala-Gln Injection were counted. Results After intervention, the top 4 department used for Ala-Gln Injection remained unchanged compared with those before intervention, they were hepatobiliary surgery, gastroenterology,respiratory medicine and thoracic surgery, the number of use cases decreased compared with that before intervention,but the total proportion did not decrease significantly. The consumption amount of Ala-Gln Injection after intervention was lower than that before intervention, the difference was statistically significant (P＜0.05). After intervention, the appropriate rate of drug selection, the rate of reaching the standard of final concentration, the correct rate of dilution carrier, the rate of reaching the standard of amino acid proportion and the qualified rate of nutrition prescription were higher than those before intervention, the differences were statistically significant (P＜0.05). The number and proportion of long-term treatment case after intervention were lower than those before intervention, but there was no significant difference between before and after intervention (P＞0.05). Conclusion The intervention of the nutrition support team is conducive to improving the reasonable clinical use of Ala-Gln, and the effect is significant. 2020 Vol. 27 (28): 163-166 [Abstract] ( 24 ) HTML (39 KB)  PDF  (0 KB)  ( 9 ) 167 Effect of PDCA in prescription audit of pharmacy intravenous admixture services WANG Yan-yan； GAO Jie； LIU Yan； LYU Chang-liang； SHAN Ya-nan； SUN Le-le Objective To explore the effect of plan-do-check action (PDCA) in prescription auditing of pharmacy intravenous admixture services (PIVAS). Methods Tracked unreasonable medical orders from 2016 to 2019, the PDCA method was used to discover the status of unreasonable medical orders, so as to analyze the reason, formulate corresponding goals and measures and continuous improvement. the reasons were analyzed, corresponding goales and measures were formulated ,then to maked continuous improvement, 2016 was before intervention, 2017 (the first round of intervention), 2018 (the second round of intervention) and 2019 (the third round of intervention) were after the implementation of the intervention. The pre-audit rate of unreasonable medical orders and the proportion of unreasonable medical orders were analyzed before and after intervention. Results After the implementation of three rounds of intervention, the pre-audit rate of unreasonable medical orders in the second and the third rounds of intervention were higher than those before intervention, the differences were statistically significant (P＜0.05). The pre-audit rate of unreasonable medical orders in the third round of intervention was higher than that in the second round, the difference was statistically significant (P＜0.05). There was no significant difference in the pre-audit rate of unreasonable medical orders between the first round of intervention and before intervention (P＞0.05). The proportion of unreasonable medical orders in the third round of intervention was lower than that before intervention, and the difference was statistically significant(P＜0.05). The second round of intervention, some proportion of unreasonable medical orders were compared with those before intervention, the differences were statistically significant (P＜0.05). There was no significant difference in the proportion of unreasonable medical orders between the first round of intervention and before intervention (P＞0.05).Conclusion PDCA circulation management can effectively promote the pre-audit rate of medical orders, reduce the proportion of unreasonable types of medical orders,and then facilitate the clinical rational use of drugs. 2020 Vol. 27 (28): 167-170 [Abstract] ( 27 ) HTML (41 KB)  PDF  (0 KB)  ( 9 ) 171 Comparison of liver toxicity of antiepileptic drugs Carbamazepine and Oxcarbazepine CHENG Yun-fei； GUAN wei Objective To explore and compare the liver toxicity of antiepileptic drugs Carbamazepine and Oxcarbazepine. Methods The clinical data of 92 epilepsy patients diagnosed and treated in our hospital from January 2016 to January 2017 were retrospectively selected. They were divided into study group (46 cases) and reference group (46 cases) according to different treatment plans. The study group was treated with Oxcarbazepine and the reference group was treated with Carbamazepine. The serum biochemical indicators of alanine aminotransferase (ALT) and the occurrence of clinical symptoms of liver injury were compared between the two groups. Results After treatment, the ALT level in the study group was (29.67±6.54) U/L, which was lower than that in the reference group of (52.08±13.09) U/L, the difference was statistically significant (P＜0.05). The total incidence of clinical liver injury adverse reactions in the study group (2.2%) was lower than that in the reference group (15.2%), the difference was statistically significant (P＜0.05).Conclusion The incidence of liver injury of the new antiepileptic drug Oxcazepine was significantly lower than that of traditional drug Carbamazepine, and the toxicity to liver was lower, worthy of clinical reference and application. 2020 Vol. 27 (28): 171-174 [Abstract] ( 27 ) HTML (34 KB)  PDF  (0 KB)  ( 10 ) 175 Effect of individualized nursing intervention on the effect of rush immunotherapy for allergic rhinitis ZHAI Yan-yan； HU Shui-hua； WANG Kun； JIANG Lan Objective To observe the effect of individualized nursing intervention on the effect of rush immunotherapy for allergic rhinitis (AR). Methods A total of 120 patients with AR who were admitted to our hospital for rapid rush immunotherapy from January to October 2019 were selected. All patients were divided into observation group and control group according to the random number table method, 60 cases in each group. In the control group, routine nursing was used, while in the observation group, on the basis of the control group, individualized nursing intervention was added.The incidence of local and systemic reactions, patient compliance, and total effectiveness rate were compared between the two groups. Results The incidence of local and systemic reactions in the observation group was lighter than that in the control group, and the differences were statistically significant (P＜0.05). The patient total compliance rate and total effectiveness rate were higher than those in the control group, with statistical differences (P＜0.05). Conclusion Implementing individualized nursing intervention on patients undergoing rush immunotherapy for AR can reduce the occurrence of complications, alleviate pain, increase compliance, and thus achieve a favorable treatment effect. 2020 Vol. 27 (28): 175-177转181 [Abstract] ( 21 ) HTML (34 KB)  PDF  (0 KB)  ( 9 ) 178 Application effect of holistic nursing in Ex-PRESS drainage device anterior chamber implantation in the treatment of refractory glaucoma CHEN Wen； XU Guo-fen Objective To explore the application effect of holistic nursing in Ex-PRESS drainage device anterior chamber implantation in the treatment of refractory glaucoma. Methods A total of 61 patients (61 eyes) with refractory glaucoma who were treated in our hospital from December 2017 to December 2019 were selected as the study objects, and all patients were divided into the observation group (30 cases) and the control group (31 cases) according to the random number table method. Both groups were treated with Ex-PRESS drainage device and anterior chamber implantation.The control group patients were given routine nursing methods, and the observation group patients were given holistic nursing on the basis of the control group. The scores of anxiety and depression, the degrees of nursing satisfaction and the incidence of complications were compared between the two groups. Results There were no significant differences in the scores of anxiety and depression of the patients between the two groups before nursing(P＞0.05). The scores of anxiety and depression of patients after nursing were lower than those before nursing, the differences were statistically significant(P＜0.05). The scores of anxiety and depression of the patients in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The total satisfaction degree of nursing of the patients in the observation group was 96.67%, which was higher than 74.19% in the control group, the difference was statistically significant (P＜0.05). The total incidence rate of complications of the patients in the observation group was 6.67%, which was lower than 25.81% in the control group, the difference was statistically significant (P＜0.05). Conclusion The application effect of holistic nursing in Ex-PRESS drainage device anterior chamber implantation in the treatment of refractory glaucoma is significant, which can improve the anxiety and depression symptoms of patients, improve nursing satisfaction degree and reduce the incidence rate of complications. 2020 Vol. 27 (28): 178-181 [Abstract] ( 23 ) HTML (36 KB)  PDF  (0 KB)  ( 12 ) 182 Effect of Kangaroo nursing on breastfeeding of mother-child separathned newborn QIN Ying ；CHEN Yi-ling； KUANG Wei-hong Objective To explore the effect of kangaroo nursing on breastfeeding of neonates separated from mothers.Methods A total of 100 neonates separated from mothers admitted to our hospital from January to December 2019 were selected. They were divided into the control group and the observation group according to random number principle, 50 cases in each group. The control group received routine nursing, the observation group was given kangaroo nursing on the basis of routine nursing. The time of first breastfeeding, the duration of first breastfeeding, the success rate of exclusive breastfeeding at 42 days postpartum and the neurobehavior of newborns in the two groups were compared. Results The first breastfeeding time in the observation group was (34.8±0.98) h postpartum, and the first breastfeeding time in the control group was (78.64±1.23) h postpartum. The first breastfeeding time in the observation group was earlier than that of the control group (P＜0.05); the first breastfeeding in the observation group continued the time was(15.02±0.43) min, the duration of the first breastfeeding in the control group was (10.56±0.29) min, the duration of the first breastfeeding in the observation group was longer than that in the control group, the difference was statistically significant (P＜0.05). The breast feeding rate of observation group was higher than that of control group (P＜0.05). The neonatal reflex, active muscle tone, passive muscle tone, and behavioral ability scores of the observation group were higher those that of the control group 30 days after birth, the differences were statistically significant (P＜0.05). Conclusion Taking kangaroo-like nursing measures for neonates separated from mothers can shorten the time of first breastfeeding, extend the duration of first breastfeeding and improve the neonatal neurobehavior. 2020 Vol. 27 (28): 182-184转188 [Abstract] ( 20 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 185 Application effect of ″red ribbon care center″ combined with comfort nursing in acquired immune deficiency syndrome patients LIU Xiao-chun； WAN Chun-hua； WU Ai-lian； HUANG Cha-ying； LUO Lian-hua； DENG Ai-hua Objective To explore the application effect of ″red ribbon care center″ combined with comfort nursing in acquired immune deficiency syndrome （AIDS） patients. Methods A total of 90 AIDS patients admitted to our hospital from June 2018 to February 2020 were selected as the research objects. They were divided into control group (n=45)and observation group (n=45) according to the parallel control method. The control group adopted the conventional nursing method, and the observation group adopted the ″red ribbon care center″+comfort nursing intervention, the anxiety score, depression score, quality of life score and satisfaction of the two groups were compared. Results The anxiety score (SAS) and depression score (SDS) of the observation group were lower than those of the control group, the quality of life score was higher than that of the control group, the total satisfaction rate was 97.78%, higher than 82.22% of the control group, the differences were statistically significant (P＜0.05）. There were no significant differences in SAS and SDS scores between the two groups before intervention (P＞0.05). Conclusion The combination of red ribbon care center and comfort nursing can improve the anxiety and depression of AIDS patients, and improve their quality of life and satisfaction. 2020 Vol. 27 (28): 185-188 [Abstract] ( 18 ) HTML (35 KB)  PDF  (0 KB)  ( 14 ) 189 Effect of simple smoking cessation intervention nursing on long-term smoking cessation effect in patients with cardiovascular disease DING Mei-zhou； FAN Qiu-yan Objective To analyze the effect of simple smoking cessation intervention nursing on long-term smoking cessation effect in patients with cardiovascular disease. Methods A total of 240 smoking patients with cardiovascular disease who were treated in the Second Affiliated Hospital of Nanchang University from June 2017 to June 2018 were selected and divided into the control group and observation group according to the random number table method, 120 cases in each group. The control group was given routine nursing without smoking cessation intervention and the observation group was given simple smoking cessation intervention nursing for every patient. A one-year follow-up was conducted to investigate the long-term effect of smoking cessation and re-hospitalization of the patients. Results The successful smoking cessation rates of patients in the observation group at 1, 6 and 12 months after discharge were 74.17%,66.67% and 56.67%，respectively, which were higher than those in the control group at 34.17%, 31.67% and 25.00%,the differences were statistically significant (P＜0.05). The relapse rates of patients in both groups were the highest one month after discharge, and no significant difference in the relapse rate of patients who successfully quitted smoking within one month was observed between the two groups (P＞0.05). The re-hospitalization rate due to cardiovascular disease in the observation group within 1 year was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Simple smoking cessation intervention nursing can effectively promote long-term smoking cessation of patients with cardiovascular diseases, and can reduce the probability of patients being re-hospitalized due to cardiovascular diseases. However, as time goes on, the smoking cessation rate of patients gradually declines, and further intervention is needed for the relapse of patients. 2020 Vol. 27 (28): 189-191 [Abstract] ( 20 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 192 Effect of continuous nursing of high quality nursing service on rehabilitation of stroke patients WAN Ren-juan Objective To observe the effect of continued nursing of high-quality nursing services on the rehabilitation of stroke patients (CVA). Methods From September 2017 to November 2018, 84 cases of CVA patients in our hospital were selected as the research object, and they were divided into the control group and the observation group by random number table method, 42 cases in each group. The observation group patients continued the use of high-quality nursing services, the patients in the control group used routine nursing, the neurological function, daily living ability, self-care ability and nursing satisfaction of the two groups. were compared. Results There were no statistically significant differences in the national institutes of health stroke scale (NHISS) score and the basel index (Barthel) score between the two groups before intervention (P＞0.05). After of intervention the two groups, the NHISS score was lower than before the intervention, Barthel score was higher than that before intervention, the differences were statistically significant (P＜0.05), and the NHISS score of the observation group after intervention was lower than that of the control group, the Barthel score of the observation group after intervention was higher than that in the control group, the differences were statistically significant (P＜0.05). There was no statistically significant difference between the two groups in the selfcare ability measurement scale (ESCA) before intervention (P＞0.05). The ESCA score of the two groups after intervention was higher than that of the intervention before, the ESCA score of the observation group after intervention was higher than that of the control group, the differences were statistically significant (P＜0.05). The nursing total satisfaction of the observation group was higher than that of the control group, the difference was statistically significance (P＜0.05).Conclusion The application of continuous nursing of high-quality nursing services in the rehabilitation of CVA patients can improve the patient′s neurological deficit and daily living ability, and improve self-care ability and nursing satisfaction. The effect is good and worth learning. 2020 Vol. 27 (28): 192-194转198 [Abstract] ( 23 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 195 Application of cognitive nursing intervention and whole-process safety strategy in assisted reproductive technology for elderly women ZHOU Juan-juan； ZHANG You-ming； DING Ming-fang ；YANG Xiao-yun； LYU Pei-juan； HU Meng-jun Objective To explore the application effect of cognitive nursing intervention and full-process safety strategy in assisted reproductive technology for elderly women. Methods From October 2018 to December 2019, a total of 36 elderly infertile patients who received in vitro fertilization-embryo transfer in our hospital were selected and divided into two groups according to the random number table method, each with 18 cases. The control group received basic nursing, and the observation group received cognitive nursing intervention and full-course nursing safety strategy management based on the control group. The cycle cancellation rate, number of eggs harvested, excellent embryo rate, clinical pregnancy rate, nursing safety risk events and satisfaction were compared between the two groups. Results There were no statistically significant differences in the cycle cancellation rate, excellent embryo rate, clinical pregnancy rate and number of eggs obtained between the two groups (P＞0.05). The total incidence of nursing safety risk events in the observation group was lower than that in the control group, and the total satisfaction was higher than that in the control group, the differences were statistically significant (P＜0.05). Conclusion Applying cognitive nursing intervention and full-process safety strategy to elderly women receiving assisted reproductive technology treatment can effectively reduce the incidence of nursing safety risk events and improve patient satisfaction. 2020 Vol. 27 (28): 195-198 [Abstract] ( 22 ) HTML (37 KB)  PDF  (0 KB)  ( 10 ) 199 Effect of cognitive behavioral intervention on mental state and drug compliance of patients with chronic hepatitis B LI Mei-qi； HU Min-hua； HU Min Objective To discuss the effect of cognitive behavioral intervention on mental state and drug compliance of patients with chronic hepatitis B (CHB). Methods A total of 60 cases with CHB who were diagnosed and treated in our hospital from January to June 2019 were selected as the study objects, and were divided into the intervention group and the control group by random number table method, 30 cases in each group. The control group was given routine nursing, and the intervention group was given cognitive behavioral intervention. Self-rating anxiety scale (SAS), self-rating depression scale (SDS), medication compliance and self-efficacy scores before and after intervention were compared between two groups. Results ①After intervention, the compliance scores of the two groups were improved compared with before the intervention, the difference was statistically significant (P＜0.05); after intervention, the compliance score of the intervention group was higher than that of the control group, and the difference was statistically significant (P＜0.05).②After intervention, the scores of SAS and SDS in the two groups were lower than those before the intervention, the scores of SAS and SDS in the intervention group were lower than those in the control group, and the differences were statistically significant (P＜0.05). ③After intervention, the self-efficacy scores of the two groups were improved compared with before the intervention, and the differences were statistically significant (P＜0.05); after intervention, the self-efficacy score of the intervention group was higher than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion Cognitive behavioral intervention can significantly improve the anxiety and depression of patients with CHB, and improve drug compliance. 2020 Vol. 27 (28): 199-201转212 [Abstract] ( 24 ) HTML (35 KB)  PDF  (0 KB)  ( 10 ) 202 Application of continuous nursing intervention in neoadjuvant chemotherapy combined with enteral nutrition support in elderly patients with advanced gastric cancer KUANG Xue-chun； SHE Gui-e； LI Xue-bing； SHI Yan-hui； YANG Zhi-you Objective To explore the effect of continuous nursing intervention in neoadjuvant chemotherapy combined with enteral nutrition support in elderly patients with advanced gastric cancer. Methods A total of 90 elderly patients with advanced gastric cancer who were hospitalized in our hospital from September 2017 to September 2019 were selected. The patients were divided into intervention group and control group using random number table method, 45 cases in each group. Patients in both groups received conventional gastric cancer nursing after admission, and in the intervention group, continuous nursing intervention was added. The nutritional status, adverse reactions of chemotherapy and quality of life （QOL） of the two groups were compared. Results Before the intervention, there were no statistical differences in nutritional indicators between the two groups （P＞0.05）. After the intervention, the nutritional indicators including albumin, prealbumin, blood lymphocyte count and body mass index （BMI） of the intervention group were higher than those of the control group,and the differences were statistically significant （P＜0.05）.In the intervention group,there were no significant differences in nutritional indicators before and after the intervention （P＞0.05）. In the control group, the prealbumin after the intervention was much lower than that before the intervention （P＜0.05）. In the control group, for other indicators, there were no significant differences between post-intervention and prior intervention （P＞0.05）. The degree of nausea, vomiting, liver and kidney function abnormalities in the intervention group were greatly milder compared with those in the control group, and the differences were statistically significant （P＜0.05）. There was no significant difference in the degree of diarrhea and bone marrow suppression between the two groups （P＞0.05）.Before intervention, there was no significant difference in each dimension of the QOL scores between the two groups（P＞0.05）. In the intervention group, the scores of physical function, role function, social function, and overall health status after the intervention were higher than those before the intervention, with statistical differences （P＜0.05）. In the intervention group, emotional function and cognitive function scores before and after the intervention did not display statistical significance （P＞0.05）. In the intervention group, the scores of nausea, vomiting, pain and diarrhea after the intervention were all lower than those before the intervention （P＜0.05）. In the intervention group, the scores of fatigue,shortness of breath, insomnia, lack of appetite, constipation and financial difficulties before and after intervention did not differ statistically （P＞0.05）. In the control group, the role function score after the intervention was higher than that before the intervention, and the difference was statistically significant （P＜0.05）. In the control group, there were no statistical differences in the scores of physical function, emotional function, cognitive function, social function, or overall health before and after the intervention （P＞0.05）. In the control group, the scores of fatigue, nausea, vomiting,pain, shortness of breath, insomnia, lack of appetite, constipation, diarrhea and financial difficulties before and after the intervention were not statistically different （P＞0.05）. After the implementation of continuous nursing intervention, the five functional aspects of physical function, role function, cognitive function, emotional function and social function of the intervention group and the overall health score in the intervention group were all higher than those of the control group, and the differences were statistically significant （P＜0.05）. After the intervention, the scores of fatigue, nausea and vomiting, pain and shortness of breath, insomnia, lack of appetite, constipation, diarrhea, and financial difficulties in the intervention group were lower than those in the control group, and the differences were statistically significant（P＜0.05）. Conclusion Continuous nursing intervention can effectively improve the nutritional status of elderly patients with advanced gastric cancer, reduce the adverse reactions of neoadjuvant chemotherapy, and ameliorate patient′s QOL,which is worthy of further exploration and promotion. 2020 Vol. 27 (28): 202-207 [Abstract] ( 27 ) HTML (49 KB)  PDF  (0 KB)  ( 9 ) 208 Effect of rehabilitation nursing plan based on PDSM on self-care ability and quality of life of patients with breast cancer after operation ZHOU Jie； HU Mei-xia； JI Fei Objective To explore the influence of the rehabilitation nursing plan based on the process of disease selfmanagement (PDSM) on the self-care ability and quality of life of breast cancer patients after operation. Methods From August 2018 to July 2019, the patients who underwent modified radical mastectomy in Department of Galactophore in Guangdong Provincial People′s Hospital were selected as the research objects. The patients were divided into observation group (60 cases) and control group (58 cases) by random number table method. The control group was given routine nursing. On this basis, the observation group was given postoperative rehabilitation nursing plan based on PDSM for intervention, the effect of intervention before and 3 months after the intervention were evaluated and compared between the two groups by the exercise of self-care agency scale and short form 36-item health survey. Results After intervention, the scores of self-care ability and quality of life in the observation group were higher than those before intervention, and higher than those in the control group, the differences were statistically significant (P＜0.05). The scores of quality of life after intervention in the control group were higher than those before intervention, the differences were statistically significant (P＜0.05). Conclusion The rehabilitation nursing plan based on PDSM can effectively improve the disease self-care ability and quality of life of patients with breast cancer after operation, and it is worthy of further promotion and application in clinical nursing. 2020 Vol. 27 (28): 208-212 [Abstract] ( 20 ) HTML (39 KB)  PDF  (0 KB)  ( 9 ) 213 Study on the application effect of continuous nursing under the guidance of Omaha system in maintenance hemodialysis patients OUYANG Liang Objective To explore the application effect of continuous nursing under the guidance of Omaha System in maintenance hemodialysis (MHD) patients. Methods A total of 70 MHD patients admitted to our hospital from June to August 2019 were selected and divided into two groups according to the random number table method, 35 cases in each group. The control group was given routine nursing and the observation group was given continuous nursing under the guidance of Omaha system. The ability of self-care, quality of life and the rate of mastering disease knowledge were compared between the two groups. Results There were no significant differences between the two groups in the scores of self care ability scale (ESCA) and health survey summary (SF-36) before intervention (P＞0.05); the score of ESCA was (117.26±10.89) points and SF-36 was (70.69±7.26) points in the observation group, which were higher than those in the control group of (95.44±10.52) points and (62.66±6.30) points, the differences were statistically significant (P＜0.05). The disease knowledge mastery rate of the observation group (94.29%) was higher than that of the control group(65.71%) after 6 months of intervention, the difference was statistically significant (P＜0.05). Conclusion The continuous nursing under the guidance of Omaha system can improve the mastery of disease knowledge, self-care ability and life quality of patients with MHD, which is worthy of clinical application. 2020 Vol. 27 (28): 213-215 [Abstract] ( 22 ) HTML (32 KB)  PDF  (0 KB)  ( 10 ) 216 Application of fast track surgery concept in the nursing care of patients with thoracoscopic lobectomy KONG Li-yun； YANG Juan； FU Jin-feng； LI Zhen； GAN Jing-hong Objective To explore the application value of fast track surgery (FTS) in the nursing care of patients with thoracoscopic lobectomy. Methods A total of 46 patients who underwent thoracoscopic lobectomyin our hospital from January 2018 to January 2020 were selected and divided into reference group and study group by random throwing,23 cases in each group. Both groups underwent thoracoscopic lobectomy, and the reference group was given routine nursing, the study group carried out high-quality perioperative nursing based on the FTS concept. The first time out of bed, the hospital stay, and the visual analogue scale (VAS) score, and the incidence of complications such as atelectasis, lung infection, and pleural effusion between two groups were compared. Results The first time of getting out of bed and the length of stay in the study group were shorter than those in the control group, and the postoperative VAS score was lower than that in the control group, with statistical differences (P＜0.05). The total incidence of postoperative complications in the study group was 13.04%, which was lower than that in the control group for 39.13%, with statistical difference (P＜0.05). Conclusion The concept of FTS plays a significant role in nursing care of patients undergoing thoracoscopic lobectomy. 2020 Vol. 27 (28): 216-218转222 [Abstract] ( 27 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 219 Effect of targeted nursing in operating room on stress response of female patients undergoing thyroid operation XIE Rong Objective To explore the effect of operation room specific nursing on stress response of female patients undergoing thyroid operation. Methods A total of 56 female patients undergoing thyroid surgery from May 2018 to November 2019 in our hospital were selected as the research objects, and were divided into control group (n=28) and observation group (n=28) according to the random number table method. The control group was given the traditional nursing method, and the observation group adopted targeted nursing method in the operating room. The pain, Hamilton anxiety scale (HAMA) score, nursing satisfaction and complications were compared between the two groups. Results The visual analogue scale (VAS) score of pain in the observation group on the 2nd postoperative day was lower than that of the control group, and the difference was statistically significant (P＜0.05). The scores of nursing satisfaction in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05).The total incidence of complications in the observation group (7.14%) was lower than that in the control group(28.57%), the difference was statistically significant (P＜0.05). The HAMA score of the two groups after care was lower than before the intervention, and the observation group was lower than the control group, the differences were statistically significant (P＜0.05). Conclusion For female patients undergoing thyroid surgery, targeted nursing intervention in operating room can reduce their pain, reduce complications, improve nursing satisfaction, and have outstanding clinical application value. 2020 Vol. 27 (28): 219-222 [Abstract] ( 22 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 223 Application value of comprehensive nursing intervention in perioperative period of elderly patients with intertrochanteric fracture of femur YANG Hui-ping； YANG Fan Objective To study the application value of comprehensive nursing intervention in perioperative period of elderly patients with intertrochanteric fracture of femur. Methods From March 2018 to March 2019, 56 elderly patients with intertrochanteric fracture of femur admitted to our hospital were selected as the subjects, who were divided into observation group (n=29) and control group (n=27) according to random sampling method. The two groups were treated by incision and internal fixation of intertrochanteric fracture. On this basis, two groups were given different nursing methods, the control group used routine nursing, and the observation group used comprehensive nursing intervention,the visual analogue score (VAS), postoperative complications and hip function score (Harries scores) at each stage after operation were compared. Results There was no significant difference in VAS score between the two groups before operation (P＞0.05). After operation, the VAS scores of the two groups were lower than those before operation, the VAS score of the observation group was lower than that of the control group, the differences were statistically significant (P＜0.05). The total incidence of postoperative complications in the observation group was lower than that in the control group (P＜0.05). The Harries scores of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05). Conclusion The application of comprehensive nursing intervention in perioperative period of elderly patients with intertrochanteric fracture of femur is significant, which can reduce the degree of pain, reduce the occurrence of postoperative complications and improve the function of hip joint. 2020 Vol. 27 (28): 223-225 [Abstract] ( 29 ) HTML (31 KB)  PDF  (0 KB)  ( 10 ) 226 Nursing value of lung function training for elderly chronic bronchitis in remission period LI Yang-mei； RAO Hui-yan Objective To explore the nursing value of lung function training for elderly chronic bronchitis in remission period. Methods A total of 80 elderly patients with chronic bronchitis during period of remission treated in our hospital from June 2018 to June 2019 were selected. They were divided into two groups according to the random number table method, 40 cases in each group. In control group, routine nursing in internal medicine combined with psychological nursing was used, while in observation group, on the basis of the control group, lung function training was added. After analyzing and comparing the efficacy and lung function improvement of the two groups, the nursing value of lung function training for elderly chronic bronchitis in remission period was estimated. Results The total response rate of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). After intervention, the forced expiratory volume at the first second (FEV1) and forced vital capacity (FVC) of the two groups were higher than those before the intervention, and the FEV1 and FVC in the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05). Conclusion For elderly patients with chronic bronchitis during period of remission, lung function training can be adopted in nursing, which has high application value, enhances the therapeutic effect, and can also improve the patient′s lung function index. It is worthy of reference and application in the clinical nursing. 2020 Vol. 27 (28): 226-228 [Abstract] ( 22 ) HTML (34 KB)  PDF  (0 KB)  ( 9 ) 229 Application effect of targeted nursing intervention in the perioperative period of cesarean section LIU Rui-qun； ZENG Dong-ming； ZHONG Yan Objective To explore the application effect of targeted nursing intervention in the perioperative period of cesarean section. Methods Retrospective analysis of 60 cases of cesarean section in our hospital from June 2018 to January 2020 was made. According to the different nursing methods, they were divided into control group and observation group, 30 cases in each group. Routine nursing mode was used in the control group, and targeted nursing mode was used in the observation group. Results After nursing, the scores of self-rating depression scale (SDS) and self-rating anxiety scale (SAS) in the observation group were lower than those in the control group, the differences were statistically significant (P ＜0.05). The total incidence of complications in the observation group was 3.33%, lower than 20.00% in the control group, the difference was statistically significant (P＜0.05); the nursing total satisfaction of the observation group was 100.00%, higher than 86.67% in the control group, the difference was statistically significant (P＜0.05). Conclusion The application of targeted nursing intervention in the perioperative period of cesarean section can alleviate the negative emotions of patients, prevent complications, improve satisfaction, effectively control risks, and has high clinical application value. 2020 Vol. 27 (28): 229-231 [Abstract] ( 23 ) HTML (33 KB)  PDF  (0 KB)  ( 9 ) 232 Application effect of psychological nursing in the nursing of acute angleclosure glaucoma ZHAO Yan Objective To explore the application effect of psychological nursing in nursing patients with acute angle closure glaucoma (AACG). Methods A total of 87 patients with AACG treated in our hospital from October 2017 to October 2019 were selected as the research objects. According to odd even number grouping method, they were divided into the reference group (n=43) and the nursing group (n=44). The reference group adopted conventional nursing methods, and the nursing group adopted psychological nursing methods on the basis of conventional nursing. The degree of anxiety and depression (assessed by the Hamilton anxiety scale, Hamilton depression scale), quality of life (assessed by the quality of life assessment scale), and psychological characteristics (impatientness, loneliness, loneliness, worry, nervous fear) were compared in the two groups. Results Before nursing, there were no significant differences in anxiety score, depression score, and quality of life between the two groups (P＞0.05). After nursing, the anxiety and depression scores of the nursing group were lower than those of the reference group, the differences were statistically significant(P＜0.05). Physical function, physical life, psychological activity, and social function scores in the nursing group were higher than those in the reference group, and the differences were statistically significant (P＜0.05). The incidence of mental characteristics such as irritability, loneliness, anxiety, and tension in the nursing group was lower than that in the reference group, and the difference was statistically significant (P＜0.05). Conclusion The clinical advantages of psychological nursing applied to the nursing of patients with AACG are obvious. It can relieve the patient′s anxiety and depression, improve their psychological state, and improve the quality of life of the patients. 2020 Vol. 27 (28): 232-234 [Abstract] ( 26 ) HTML (33 KB)  PDF  (0 KB)  ( 10 ) 235 Non-drug care on the neonatal pain，heart rate and blood oxygen saturation during the invasive operation XU Li-ping Objective To study the influence of non-drug care on the neonatal pain, heart rate and blood oxygen saturation during the invasive operation. Methods A total of 100 neonates undergoing the invasive operation from January to December 2019 in our hospital were selected and divided into two groups by computer random method, 50 cases in each group. The observation group took the non-drug care; the control group took the conventional nursing. Pain scores,heart rate and oxygen saturation between two groups were compared. Results Upon puncture, after 30 and 60 s of puncture, pain scores in the observation group were lower than those of control group, the differences were statistically significant (P＜0.05), before puncture, heart rate and oxygen saturation between groups showed no statistically significant differences (P＞0.05); during and after puncture, heart rate in the observation group was lower than that of control group,during and after puncture, oxygen saturation in the observation group was higher than that of control group, the differences were statistically significant (P＜0.05). Conclusion Non-drug care can alleviate the pain of invasive operation and reduce the effecton short-term adverse reactions. 2020 Vol. 27 (28): 235-237转241 [Abstract] ( 24 ) HTML (33 KB)  PDF  (0 KB)  ( 9 ) 238 Application effect of high-quality nursing methods in hospitalized schizophrenia patients DENG Fei-mei； WEN Xiu-hong； ZHOU Kan-ging Objective To explore the application effect of high-quality nursing methods for hospitalized schizophrenia patients. Methods A total of 100 inpatients with schizophrenia in our hospital from December 2017 to December 2018 were selected as the research subjects, and the patients were divided into conventional nursing mode group and highquality nursing group using random number table method, 50 cases in each group. Patients in the conventional nursing mode group received routine care, and patients in the high-quality nursing group received high-quality care, degree of satisfaction, social function, physical health, mental health, material life four quality of life scores, social function defect screening scale; positive and negative symptom scales; and concise schizophrenia symptom scale scores; total incidence of risk events were compared between two groups. Results The total satisfaction of high-quality nursing group was higher than that of routine nursing mode group, and the difference was statistically significant (P＜0.05). There were no significant differences in the scores of social function deficiency screening scale, positive and negative symptom scale, and concise schizophrenia symptom scale in the two groups before nursing (P＞0.05). The positive, negative and positive symptoms scales and the concise schizophrenia symptoms scale scores after nursing were lower than those of the conventional nursing mode group, and the differences were statistically significant (P＜0.05). The scores of quality of life factors in the high-quality nursing group were higher than those in the conventional nursing mode group, and the differences were statistically significant (P＜0.05). The total incidence of risk events in the high-quality nursing group was lower than that in the conventional nursing mode group, and the difference was statistically significant (P＜0.05).Conclusion High-quality nursing can improve the mental symptoms of inpatients with schizophrenia, improve the quality of life, reduce risk and improve patient satisfaction. 2020 Vol. 27 (28): 238-241 [Abstract] ( 21 ) HTML (34 KB)  PDF  (0 KB)  ( 10 ) 242 Application value of positive psychology in nursing care of senile schizophrenia patients TANG Ning； YUAN Ping； LIAO Yan； ZENG Wei-xiang； GUO Xiao-yu Objective To explore the application value of positive psychology in nursing care of senile schizophrenia patients. Methods A total of 92 elderly schizophrenic patients admitted to our hospital from August 2018 to January 2020 were selected as research objects and divided into control group (n=46) and research group (n=46) according to random number table method. Patients in the control group were given conventional nursing methods and patients in the research group were given positive psychological nursing methods. The brief psychiatric scale (BPRS), screening social disability scale (SDSS), social adaptation assessment scale (SAFE) and quality of life measuring scale (COOP-WONCA)scores of the two groups were compared. Results Before nursing, there were no significant differences in BPRS, SDSS,SAFE, COOP-WONCA scores between the two groups (P＞0.05). After nursing, the scores of anxiety, depression, lack of vitality, thinking disorder, activation, hostility and suspicion in the study group were lower than those in the control group, with statistical differences (P＜0.05). The SDSS, SAFE, COOP-WONCA scores after nursing of the two group were lower than those before nursing, the SDSS, SAFF, COOP-WONCA scores in the study group was lower than those of the control group, with statistical differences (P＜0.05). Conclusion The application of positive psychology theory in the nursing of senile schizophrenic patients can effectively improve the quality of life of the patients, improve the diseases, thus enhancing the social function of the patients and improving the clinical symptoms of the patients. This theory is worth promoting. 2020 Vol. 27 (28): 242-244 [Abstract] ( 29 ) HTML (33 KB)  PDF  (0 KB)  ( 12 ) 245 Application effect of people-oriented nursing concept applied to patients with rectal cancer chemoradiotherapy HAN Feng Objective To explore the application effect of people-oriented nursing concept applied to patients with rectal cancer undergoing radiotherapy and chemotherapy. Methods A total of 84 patients with rectal cancer who were admitted to our hospital from March 2018 to March 2019 treated with radiotherapy and chemotherapy were selected. They were divided into two groups by blue white dichroic method, 42 cases in each group. The control group was given routine nursing. The observation group was given people-oriented nursing concept, and the application effect of the two groups was compared. Results There were no significant differences in the scores of anxiety, depression and quality of life between the two groups before nursing (P＞0.05); the score of anxiety was (37.25±5.28) points and depression score was (38.28±6.27) points in the observation group after nursing, which were lower than those in the control group of(43.21±5.37) and (45.36±6.41) points, with statistical differences (P＜0.05). The score of quality of life was (75.31±7.46)points in the observation group, which was higher than that of the control group of (69.35±8.21) points, the difference was statistically significant (P＜0.05). The total incidence of complications in the observation group (19.05%) was lower than that in the control group (45.24%), the difference was statistically significant (P＜0.05). Conclusion The application effect of people-oriented nursing concept in the radiotherapy and chemotherapy of rectal cancer patients can effectively alleviate the negative emotions of patients, reduce complications and improve the quality of life. 2020 Vol. 27 (28): 245-247 [Abstract] ( 20 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 248 Application effect of new high-quality nursing in orthognathic surgery combined with orthodontics for treatment of maxillofacial deformities LIU Bo； TONG Ling； ZHANG Hui； JIA Li-sha Objective To explore the application effect of new high-quality nursing in orthodontic surgery combined with orthodontics for treatment of maxillofacial deformities. Methods A total of 80 patients with dentofacial deformity admitted to our hospital from August 2018 to August 2019 were selected as research objects. All patients were divided into control group(n=40)and research group(n=40) according to odd even grouping mode. The patients in the control group were treated with routine nursing intervention and the patients in the research group were treated with new high-quality nursing intervention on the basis of the control group. The waiting time, hospitalization time and thread removal time of the two groups were compared, the recovery effect of the two groups after nursing intervention was evaluated, and the postoperative complications was obeserved. Results The waiting time, hospitalization time and suture removal time in the research group were shorter than those in the control group, the differences were statistically significant (P＜0.05).The total effective rate of patients in the research group was 97.50%, which was higher than that in the control group(80.00%), the difference was statistically significant (P＜0.05). The total incidence of complications in the research group was 5.00%, which was lower than that in the control group(20.00%),the difference was statistically significant(P＜0.05). Conclusion The application of the new high quality nursing service in the orthodontic treatment of patients with dentofacial deformity has a significant effect. It can shorten the waiting time before operation, speed up the time of line removal after operation, shorten the time of hospitalization, and reduce the total incidence of complications. Therefore,it is worthy of study and promotion in clinical. 2020 Vol. 27 (28): 248-250 [Abstract] ( 17 ) HTML (31 KB)  PDF  (0 KB)  ( 11 ) 251 Application effect of clinical nursing pathway in patients with nodular goiter surgery YAN Li-li Objective To investigation the application effect of clinical nursing pathway in patients with nodular goiter surgery. Methods Forty-seven patients with nodular goiter who were treated in our hospital from May 2018 to October 2019 (all received surgery) were selected as the research subjects. Patients were divided into a reference group (23 patients, who performed routine nursing) and nursing group (24 patients, who performed clinical nursing pathways on conventional nursing techniques) according to the even-odd grouping method. The patients two groups were compared with each other about their knowledge of health and quality of life before and after nursing. Results The health knowledge awareness rate of patients in the nursing group was higher than that in the reference group, and the difference was statistically significant (P＜0.05). Before nursing, there was no significant difference in the quality of life scores between the two groups of patients (P＞0.05). The quality of life scores of the two groups of patients after nursing were higher than those before nursing, and the differences were statistically significant (P＜0.05). After nursing, the scores of physiological function, social function, and emotional function of the patients in the nursing group were higher than those in the reference group, and the differences were statistically significant (P＜0.05). Conclusion Compared with conventional nursing, the advantages of clinical nursing pathway applied to the nursing of patients with nodular goiter surgery are more obvious, which can effectively improve patients′mastery of disease-related health knowledge and improve patients′ quality of life. 2020 Vol. 27 (28): 251-252 [Abstract] ( 23 ) HTML (31 KB)  PDF  (0 KB)  ( 15 )

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