超早期小骨瓣血肿清除术对高血压脑出血患者血管内皮功能、炎症因子及临床效果研究

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Abstract Objective To investigate the vascular endothelial function, inflammatory factors and clinical effects of ultra-early small bone flap hematoma removal on hypertensive cerebral hemorrhage patients. Methods A total of 80 cases hypertensive cerebral hemorrhage patients admitted to our hospital from January 2017 to December 2019 were selected as research objects, and they were divided into two groups according to random number table method, 40 cases in each group. All patients underwent surgical intervention under general anesthesia tracheal intubation. The observation group underwent ultra-early small bone flap cerebral hemorrhage removal, while the control group underwent early small bone flap cerebral hemorrhage removal. The changes of vascular endothelial growth ability, vascular endothelial function and inflammatory factor indexes were compared between the two groups 3 days after treatment. Intracranial pressure and cerebral perfusion pressure were counted 3 days after operation. Results On the 3 days after treatment,the levels of VEGF and bFGF in vascular endothelial growth capacity of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05); ET-1 level in vascular endothelial function index of the observation group was lower than that of the control group, the difference was statistically significant (P＜0.05); NO level of the observation was higher than that of the control group, the difference was statistically significant(P＜0.05); hs-CRP and TNF-α levels in inflammatory factors of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05); intracranial pressure of the observation group was lower than that of the control group,the difference was statistically significant (P＜0.05); and cerebral perfusion pressure of the observation was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion For hypertensive cerebral hemorrhage patients, ultra-early minimally invasive hematoma removal with small bone flap can effectively reduce vascular endothelial function and inflammatory factors in the body, and can also reduce intracranial pressure and increase cerebral perfusion pressure, it helps improve patient prognosis.

Key words： Ultra-early small bone flap hematoma removal Hypertensive cerebral hemorrhage Vascular endothelial function Inflammatory factors Clinical effect

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	SHANG Cheng-sheng

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SHANG Cheng-sheng. Study on vascular endothelial function, inflammatory factors and clinical effects of ultra-early small bone flap hematoma removal on hypertensive cerebral hemorrhage patients[J]. 中国当代医药, 2020, 27(28): 78-81.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I28/78

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