高血压合并2型糖尿病患者大血管病变的影响因素分析及对策

Abstract
Figure/Table
References (16)
Related Citation (15)

Download: PDF (0 KB) HTML (35 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the influencing factors of macroangiopathy in patients with hypertension and type 2 diabetes mellitus and its countermeasures. Methods The clinical data of 200 patients with hypertension and type 2 diabetes mellitus who were treated in the Third Hospital of Nanchang from November 2018 to November 2019 were retrospectively analyzed, and they were divided into lesion group (n=120) and non-lesion group (n=80) according to the abnormal changes of carotid artery intima. The general data and biochemical indexes of two groups were collected, and the influencing factors of macroangiopathy in patients with hypertension and type 2 diabetes mellitus were analyzed.The lesion group was divided into two groups according to different intervention methods, with 60 cases in each group.Group A was given routine treatment, and group B added lifestyle intervention. The situations of patients before intervention and after intervention for 12 weeks were compared. Results The fasting insulin (FINS), intima-media thickness (IMT), homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment-β cell function (HOMA-βF) in lesion group were higher than those in non-lesion group, with statistically significant differences (P＜0.05). There were no statistical differences in the body mass index (BMI), fasting plasma glucose (FPG)and glycated hemoglobin (HbA1c) between the lesion group and the non-lesion group (P＞0.05). Multivariate Logistic regression analysis found that FINS≥55.50 pmol/L, IMT≥1.10 mm, HOMA-IR≥3.25%, and HOMA-βF≥3.40%were risk factors for macroangiopathy in patients with hypertension and type 2 diabetes mellitus (OR＞1, P＜0.05). After intervention, the levels of FINS and HOMA-IR in group B were lower than those in group A, and the differences were statistically significant(P＜0.05).Conclusion FINS≥55.50 pmol/L, IMT≥1.10 mm, HOMA-IR≥3.25%, and HOMA-βF≥3.40% are risk factors of macroangiopathy in patients with hypertension and type 2 diabetes mellitus. Early treatment and effective lifestyle intervention can improve insulin resistance, and delay the development of macroangiopathy.

Key words： Hypertension and type 2 diabetes mellitus Insulin resistance Macroangiopathy

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	SONG Guo-liang
	WAN Zhen-ying
	XIE Ying

Cite this article:

SONG Guo-liang,WAN Zhen-ying,XIE Ying. Influencing factors analysis of macroangiopathy in patients with hypertension and type 2 diabetes mellitus and its countermeasures[J]. 中国当代医药, 2020, 27(28): 43-46.

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I28/43

[1]	杨士桂，林海，杨虹.活性维生素D3对2 型糖尿病患者胰岛素抵抗的影响研究[J].浙江医学，2019，41（10）：995-997.
[2]	窦家庆，唐松涛，杨启程，等.2 型糖尿病患者的血管并发症与血糖控制及其危险因素的相互关系[J].安徽医科大学学报，2017，52（3）：426-430.
[3]	高芸，吴萍，周宇洁.2 型糖尿病不同血管并发症与脂溶性维生素及营养代谢指标的关系[J].同济大学学报（医学版），2019，40（5）：629-633，643.
[4]	陆再英，钟南山.内科学[M].北京：人民卫生出版社，2008：769-773.
[5]	中国高血压防治指南修订委员会，高血压联盟.中国高血压防治指南（2018年修订版）[J].中国心血管杂志，2019，24（1）：24-56.
[6]	王艳.visfatin 与2 型糖尿病动脉粥样硬化关系研究进展[J].中华实用诊断与治疗杂志，2016，30（8）：732-734.
[7]	姚佳琦，阮芸，谭擎缨，等.男性2 型糖尿病患者AIP 与IR VFA 的相关性研究[J].浙江临床医学，2016，18（2）：201-203.
[8]	陈涛，黄丽华，涂梅，等.2 型糖尿病大血管病变患者足背动脉内-中膜厚度与胰岛素抵抗的相关性研究[J].中国糖尿病杂志，2016，24（8）：712-715.
[9]	蔡鹏.胰岛素清除率下降机制及其对大血管损伤作用的研究进展[J].心血管病学进展，2016，37（3）：292-295.
[10]	王环君，皮银珍，谭荣，等.新发2 型糖尿病并代谢综合征患者颈动脉内膜中层厚度相关影响因素分析[J].中南医学科学杂志，2016，44（5）：527-530.
[11]	赵文倩，王艳军.补体系统与糖尿病微血管病变关系的研究进展[J].中国医师杂志，2019，21（6）：947-950.
[12]	桑花燕，赵文化，郭爱珍，等.男性2 型糖尿病合并颈动脉硬化斑块的相关危险因素分析[J].中国药物与临床，2018，18（4）：590-592.
[13]	何涛，易桂文，徐玲文.利拉鲁肽联合参芪降糖颗粒对胰岛素控制不佳的2 型糖尿病伴亚临床大血管病变患者血糖及血管重塑的影响[J].现代中西医结合杂志，2019，28（16）：1736-1740.
[14]	许秀萍，张雪英.个性化心理护理对2 型糖尿病伴大血管病变患者预后的影响[J].齐鲁护理杂志，2017，23（17）：16-18.
[15]	胡明英.抗阻+有氧运动锻炼对糖尿病大血管病变患者胰岛素抵抗、斑块性质及脂代谢的影响[J].海南医学院学报，2017，23（16）：2196-2199.
[16]	高飞，张丽娟，张文，等.关于2 型糖尿病大血管病变相关危险因素分析[J].当代医学，2019，25（2）：29-31.