连续性护理干预在老年进展期胃癌患者新辅助化疗联合肠内营养支持中的应用

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Abstract Objective To explore the effect of continuous nursing intervention in neoadjuvant chemotherapy combined with enteral nutrition support in elderly patients with advanced gastric cancer. Methods A total of 90 elderly patients with advanced gastric cancer who were hospitalized in our hospital from September 2017 to September 2019 were selected. The patients were divided into intervention group and control group using random number table method, 45 cases in each group. Patients in both groups received conventional gastric cancer nursing after admission, and in the intervention group, continuous nursing intervention was added. The nutritional status, adverse reactions of chemotherapy and quality of life （QOL） of the two groups were compared. Results Before the intervention, there were no statistical differences in nutritional indicators between the two groups （P＞0.05）. After the intervention, the nutritional indicators including albumin, prealbumin, blood lymphocyte count and body mass index （BMI） of the intervention group were higher than those of the control group,and the differences were statistically significant （P＜0.05）.In the intervention group,there were no significant differences in nutritional indicators before and after the intervention （P＞0.05）. In the control group, the prealbumin after the intervention was much lower than that before the intervention （P＜0.05）. In the control group, for other indicators, there were no significant differences between post-intervention and prior intervention （P＞0.05）. The degree of nausea, vomiting, liver and kidney function abnormalities in the intervention group were greatly milder compared with those in the control group, and the differences were statistically significant （P＜0.05）. There was no significant difference in the degree of diarrhea and bone marrow suppression between the two groups （P＞0.05）.Before intervention, there was no significant difference in each dimension of the QOL scores between the two groups（P＞0.05）. In the intervention group, the scores of physical function, role function, social function, and overall health status after the intervention were higher than those before the intervention, with statistical differences （P＜0.05）. In the intervention group, emotional function and cognitive function scores before and after the intervention did not display statistical significance （P＞0.05）. In the intervention group, the scores of nausea, vomiting, pain and diarrhea after the intervention were all lower than those before the intervention （P＜0.05）. In the intervention group, the scores of fatigue,shortness of breath, insomnia, lack of appetite, constipation and financial difficulties before and after intervention did not differ statistically （P＞0.05）. In the control group, the role function score after the intervention was higher than that before the intervention, and the difference was statistically significant （P＜0.05）. In the control group, there were no statistical differences in the scores of physical function, emotional function, cognitive function, social function, or overall health before and after the intervention （P＞0.05）. In the control group, the scores of fatigue, nausea, vomiting,pain, shortness of breath, insomnia, lack of appetite, constipation, diarrhea and financial difficulties before and after the intervention were not statistically different （P＞0.05）. After the implementation of continuous nursing intervention, the five functional aspects of physical function, role function, cognitive function, emotional function and social function of the intervention group and the overall health score in the intervention group were all higher than those of the control group, and the differences were statistically significant （P＜0.05）. After the intervention, the scores of fatigue, nausea and vomiting, pain and shortness of breath, insomnia, lack of appetite, constipation, diarrhea, and financial difficulties in the intervention group were lower than those in the control group, and the differences were statistically significant（P＜0.05）. Conclusion Continuous nursing intervention can effectively improve the nutritional status of elderly patients with advanced gastric cancer, reduce the adverse reactions of neoadjuvant chemotherapy, and ameliorate patient′s QOL,which is worthy of further exploration and promotion.

Key words： Continuous nursing Gastric cancer Chemotherapy Enteral nutrition Quality of life

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	Articles by authors
	KUANG Xue-chun
	SHE Gui-e
	LI Xue-bing
	SHI Yan-hui
	YANG Zhi-you

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KUANG Xue-chun,SHE Gui-e,LI Xue-bing, et al. Application of continuous nursing intervention in neoadjuvant chemotherapy combined with enteral nutrition support in elderly patients with advanced gastric cancer[J]. 中国当代医药, 2020, 27(28): 202-207.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I28/202

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