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Quick Search     Adv Search 2021 Vol. 28, No. 29 Published: 2021-10-18   4 Mechanism of Jiechangyan Qixiao Granules in the treatment of ulcerative colitis based on network pharmacology and bioinformatics SUN Yu-jing；HUO Zhi-peng；WANG Yu；LI Rui-ming；QIN Min-jian；HE Yi Objective To investigate the mechanism and explore the active compounds, key targets and signal pathways of Jiechangyan Qixiao Granules in the treatment of ulcerative colitis, it was analyzed by network pharmacology and bioinformatics.Methods Firstly, based on the total chemical composition of Jiechangyan Qixiao Granules, pharmacology analysis platform of traditional Chinese medicine system (TCMSP), chemistry database and Swiss ADME were combined to search and screen the potential targets related to compounds.Meanwhile, the targets related to ulcerative colitis were acquired through DiGSeE and Gene Cards, and the drug-disease targets were obtained by intersecting the results of these two databases.The drug-disease-target network was constructed through visualization analysis of STRING and Cytoscape software.Moreover, core targets were screened based on the algorithm of network topology.Then, GO function and KEGG metabolic pathway enrichment analysis of these core targets were performed by DAVID 6.8 database.Finally, the mechanism of Jiechangyan Qixiao Granules in treating ulcerative colitis was analyzed with relevant literatures.Results There were 12 potential active compounds and 269 potential interactive targets in Jiechangyan Qixiao Granules, with 32 core targets were selected from 64 drug-disease targets.A total of 32 enrichment results were obtained by GO analysis, mainly involving inflammatory response, positive regulation of nitric oxide biosynthetic process, etc.Simultaneously, 32 metabolic pathways were obtained by KEGG, primarily including pathways in cancer, tumor necrosis factor signaling pathway, etc. Conclusion The characteristic of Jiechangyan Qixiao Granules with multi-compounds, multi-targets, multi-components and multi-pathways in the treatment of ulcerative colitis is revealed by network pharmacology.The potential active compounds, key targets and mechanism are predicted as well.Moreover, there is a high degree of coincidence between prediction and pharmacological experiments, which can verify each other.These results provide clues and references for the subsequent screening of effective parts and the study of pharmacodynamic material basis. 2021 Vol. 28 (29): 4-8 [Abstract] ( 47 ) HTML (44 KB)  PDF  (0 KB)  ( 7 ) 9 Study on the expression of TNF-α and MAPK signal transduction pathwayin placenta of preeclampsia ZHOU Xiao；LI Yao；WANG Chen Objective To compare the expression of tumor necrosis factor-α (TNF-α) in serum and mitogen-activated protein kinases (MAPK) signal transduction pathway proteins in placental tissues of preeclampsia and normal pregnant women, so as to provide experimental basis for the study of the pathogenesis of preeclampsia.Methods A total of 30 single-child pregnant women who took cesarean delivery because of preeclampsia in Jiangxi Maternal and Child Health Hospital from January 2019 to December 2019 were selected as study group.The control group was 30 cases of singleborn pregnant women with cesarean section due to scar uterus, narrow pelvis and misalignment.Then the expression of TNF-α in serum of two groups of pregnant women was detected by ELISA method and the expression of MAPK signal transduction pathway related protein p-p38, p-c-Jun-N-terminal kinase (p-JNK), p-extra cellular signal-regulated protein kinase (p-ERK) and downstream molecular nuclear factor-κBp65 (NF-κBp65), c-fos, c-Jun in placental tissue of two groups of pregnant women was detected by Western blot method.Results The expression level of serum TNF-α in study group was higher than that in control group, the difference was statistically significant (P＜0.05).The expression of p-p38 and p-JNK in placental tissue of study group was higher than that in control group, the expression of p-ERK was lower than that of control group, the differences were statistically significant (P＜0.05).The expression of TNF-α in pregnant women′s serum was positively correlated with the expression level of p-p38, p-JNK in placental tissue,while negatively correlated with the expression level of p-ERK.The expression of downstream molecular NF-κBp65、c-fos、c-Jun of MAPK pathway in study group were higher than those in normal study group, the differences were statistically significant (P＜0.05).Conclusion MAPK signaling pathways may be involved in the pathogenesis of preeclampsia by regulating the inflammatory response. 2021 Vol. 28 (29): 9-12 [Abstract] ( 39 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 13 Correlation analysis between postoperative hypercoagulability and peripheral blood circulating tumor cells in patients with lung cancer WANG Xiao-kang；YUAN Jin-quan Objective To investigate the relationship between postoperative hypercoagulability and circulating tumor cells (CTC) in patients with lung cancer.Methods A total of 120 lung cancer patients admitted to the Department of Thoracic Surgery of Songshan Lake Central Hospital from February 2015 to May 2017 were retrospectively selected as the research objects.According to the detection results of peripheral blood CTC, they were divided into CTC-positive group (42 cases) and CTC-negative group (78 cases).The levels of D-dimer (D-D), fibrinogen (FIB) and platelets (PLT)in peripheral blood of patients were detected and compared.According to the prognosis, the patients were divided into death group and survival group, and the influencing factors of postoperative prognosis were analyzed.Results The proportion of postoperative tumor metastasis, lymph node metastasis and TMN stage Ⅲin CTC-positive group were higher than those in CTC-negative group, and the differences were statistically significant (P＜0.05).The levels of D-D,FIB and PLT in CTC-positive group were higher than those in CTC-negative group, and the differences were statistically significant (P＜0.05).At the end of follow-up, 5 patients were detached, which were divided into the death group(35 cases) and the survival group (80 cases) according to their prognosis.There were statistically significant differences in TMN staging and CTC between the two groups (P＜0.05).Multivariate analysis showed that TMN stage and CTC were independent influencing factors of death (P＜0.05).Conclusion CTC-positive lung cancer patients are prone to blood hypercoagulability after surgery, accompanied by postoperative tumor metastasis, which has a certain reference value for the postoperative prognosis of patients. 2021 Vol. 28 (29): 13-16 [Abstract] ( 47 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 17 Comparison of clinical efficacy of minimally invasive technique and open"L" incision in the treatment of Sanders type Ⅱand Ⅲcalcaneal fractures CHEN Jian-song Objective To explore the Comparison of clinical efficacy of minimally invasive technique and open "L" incision in the treatment of Sanders type Ⅱand Ⅲcalcaneal fractures.Methods A retrospective selection of 86 patients with calcaneal fractures admitted to the Department of Traumatology and Orthopedics, Fuzhou Second Hospital from October 2015 to February 2018, were divided into minimally invasive group (42 cases) and open group (44 cases) according to surgical methods.The minimally invasive group was treated with minimally invasive small technique combined with internal fixation, and the open group was treated with an open "L" incision.The operation time and intraoperative blood loss were compared between the two groups; the visual analogue scale (VAS) scores of the two groups at 2 weeks, 3 months and 8 months after the operation were compared; the Bohler angle, Gissane angle before and after surgery were compared between the two groups; the postoperative complications and Maryland foot score (MFS) at 8 months after surgery were compared between the two groups.Results The operation time, intraoperative blood loss and hospitalization days in the minimally invasive group were less than those in the open group, and the differences were statistically significant (P＜0.05).The Bohler angle and Gissane angle of the two groups at 8 months after operation were higher than those before operation, and the differences were statistically significant (P＜0.05).The total incidence of postoperative complications in the minimally invasive group was lower than that in the open group, and the difference was statistically significant (P＜0.05).The excellent and good rate of MFS score in the minimally invasive group at 8 months after the operation was higher than that in the open group, and the difference was statistically significant (P＜0.05).Conclusion Minimally invasive small technique combined with internal fixation in the treatment of Sanders typeⅡand Ⅲcalcaneal fractures has the advantages of less trauma, reduction under direct vision, reliable reduction and fixation, and low complications, which is worthy of clinical application. 2021 Vol. 28 (29): 17-20 [Abstract] ( 50 ) HTML (37 KB)  PDF  (0 KB)  ( 9 ) 21 Predictive value of neutrophil to lymphocyte ratio and fibrinogen in the disease progression of ovarian cyst torsion SHI Sen-sen Objective To investigate the predictive value of neutrophil to lymphocyte ratio (NLR) and fibrinogen (FIB)in the disease progression of ovarian cyst torsion.Methods Clinical data of 60 non-pregnant patients who were preoperatively diagnosed with ovarian cyst tortion and confirmed on intraoperative findings from January 2016 to March 2020 in Fujian Provincial Maternity and Children′s Health Hospital were retrospectively analyzed and classified into the normal group (n=23), congestive group (n=18) and necrotic group (n=19) depending on the postoperative histopathological examinations.The clinical data of the three groups were statistically analyzed.The receiver operating characteristic(ROC) curves of the normal group and the hyperemic group, the necrotic group and the non-necrotic group were drawn respectively, and the clinical value of NLR and FIB in predicting torsion accessory hyperemia and necrosis was analyzed.Results The level of NLR in hyperemia group was higher than that in normal group, and the difference was statistically significant (P＜0.05).The level of FIB in the necrotic group was higher than that in the non-necrotic group, the difference was statistically significant (P＜0.05).The area under curve (AUC) predicted by NLR and FIB were 0.785 and 0.771, the critical value was 3.11 and 2.91 g/L, respectively, and the sensitivity was 88.9% and 73.7%, respectively.Conclusion The NLR and FIB have predictive value in tissular congestion and necrosis of adnexal torsion to some extent. 2021 Vol. 28 (29): 21-24转29 [Abstract] ( 43 ) HTML (36 KB)  PDF  (0 KB)  ( 9 ) 25 Expression of poly adenosine diphosphate ribose polymerase 1 and apoptosis inducing factor in ovarian cancer and its clinicopathological significance QIN Ao-xiang；SHEN Li  Objective To investigate the expression of poly adenosine diphosphate ribose polymerase 1 (PARP1) and apoptosis inducing factor (AIF) in ovarian cancer and their relationship with clinicopathological characteristics and disease-free survival (DFS) of the patients.Methods A total of 70 cases of pathologically confirmed ovarian cancer tissue specimens and corresponding para cancerous tissue specimens in Songzi Hospital of Traditional Chinese Medicine from June 2015 to June 2017 were selected.The expression of PARP1 and AIF in tissue was detected by immunohistochemistry, and Spearman correlation analysis, Kapalan-Meier survival curve analysis, and Cox proportional risk model analysis were performed.Results The positive expression rates of PARP1 and AIF in ovarian cancer tissues were higher than those in para-cancerous tissues (P＜0.05).The clinical stage Ⅲ～Ⅳ, low differentiation and lymph node metastasis proportion of high PARP1 and AIF expression patients were higher than those of low PARP1 and AIF expression patients (P＜0.05).There was a high positive correlation between PARP1 and AIF expression in ovarian cancer tissues(r=0.791, P＜0.05).The median DFS of ovarian cancer patients with high PARP1 expression was 6.78 months, which was shorter than that of low PARP1 expression patients, 23.32 months (P＜0.05).The median DFS AIF of ovarian cancer patients with high AIF expression was 7.80 months, which was shorter than that of low AIF expression patients, 28.00 months (P＜0.05).Univariate analysis showed that clinical stage, differentiation degree, lymph node metastasis or not,PARP1, and AIF were all risk factors affecting the prognosis of ovarian cancer patients (P＜0.05).Multivariate Cox analysis showed that PARP1, AIF, clinical stage, and differentiation degree were independent risk factors affecting the prognosis of ovarian cancer patients (P＜0.05).Conclusion The positive expression rates of PARP1 and AIF in ovarian cancer tissues are significantly higher than those in para cancerous tissues, which are correlated with clinical stage,differentiation degree, lymph node metastasis or not, and DFS of ovarian cancer patients, and may be used as a clinical reference indexes to evaluate the prognosis of ovarian cancer patients. 2021 Vol. 28 (29): 25-29 [Abstract] ( 37 ) HTML (37 KB)  PDF  (0 KB)  ( 9 ) 30 Systematic review of correlation between vitamin D and immunity in patients with unexplained recurrent spontaneous abortion WU Yun-yan；QIN Xia；QIU Feng Objective To conduct a systematic review of the correlation between vitamin D and immunity in patients with recurrent miscarriage (URSA).Methods PubMed, EBSCO, CNKI, CBM, VIP, and WanFang Data databases were searched for control studies related to vitamin D and immunity in patients with URSA.The search time limit was from the establishment of the database to January 2021.In the case control study, patients with URSA were as the experimental group and normal pregnant women as the control group.In the randomized controlled trial, patients with URSA were divided into experimental group and control group.The case control study had no intervention.In the randomized controlled trial, both the experimental group and the control group were given routine treatment, and the experimental group was given vitamin D in addition to the intervention of the control group.The studies were screened by two independent researchers and data were extracted.After quality evaluation of included studies, RevMan 5.3 software was used for meta-analysis.Results A total of 12 literatures were included, including 2114 subjects.Meta-analysis results showed that the level of 25-hydroxyvitamin D (25[OH]D) in experimental group was lower than that in control group, the difference was statistically significant (SMD=-1.46, 95%CI[-2.08, -0.84], P＜0.000 01).The positive rates of anti-thyroid peroxidase antibody (TPOAb), anticardiolipin antibody (ACA) and antinuclear antibody (ANA) in URSA patients of 25(OH)D＜30 ng/ml group were higher than those in URSA patients of 25(OH)D≥30 ng/ml group, and the differences were statistically significant (OR=3.87, 95%CI[2.27, 6.60], P＜0.000 01; OR=2.96, 95%CI [1.53, 5.75],P=0.001; OR=2.54, 95%CI[1.54, 4.17], P=0.0002).CD4+T and CD56+NK cell counts in URSA patients of 25(OH)D＜30 ng/ml group were higher than those in URSA patients of 25(OH)D≥30 ng/ml group, the differences were statistically significant (SMD=1.65, 95%CI[1.29, 2.01], P＜0.000 01; SMD=0.83, 95%CI[0.35, 1.31], P=0.0008).There was no significant difference in CD19+B cell count between the URSA patients of 25(OH)D＜30 ng/ml group and the URSA patients of 25(OH)D≥30 ng/ml group (SMD=1.74, 95%CI[-1.07, 4.56], P=0.22).The abortion rate of URSA patients in experimental group was lower than that of URSA patients in control group, and the difference was statistically significant(RR=0.53, 95%CI[0.31, 0.89], P=0.02).Conclusion Deficiency of 25(OH)D is associated with increased CD4+T CD56+NK cell counts and autoimmune antibody, and adequate vitamin D supplementation may prevent URSA.However, this study was limited by the number and quality of subjects included in the study, and the conclusion needs to be verified by more high-quality studies. 2021 Vol. 28 (29): 30-34转38 [Abstract] ( 40 ) HTML (46 KB)  PDF  (0 KB)  ( 9 ) 35 Research progress on vulvar hypopigmentation disease GUAN Xin-yi ；ZHAO Chun-mei Vulvar hypopigmentation disease is a chronic inflammatory disease of gynecology, mainly including vulvar chronic simple lichen (LSC), vulvar lichen sclerosus (LS), and lichen planus.The main feature is itching of the vulva.The skin and mucous membrane tissues of the vulva often undergo pigment changes and degeneration.The pathological mechanism is not yet clear, clinical treatment is mainly to relieve symptoms and delay recurrence, including drug therapy, physical therapy and surgical treatment.Although the disease is a benign disease, it may affect the patient′s daily life and deteriorate without active treatment and control.This article will review the clinical symptoms, etiology, pathology and treatment of the disease. 2021 Vol. 28 (29): 35-38 [Abstract] ( 45 ) HTML (42 KB)  PDF  (0 KB)  ( 6 ) 39 Potential of Raman spectroscopy to identify sepsis of different etiologies DU Jin；XIA Shu-Xiang Sepsis is a fatal organ dysfunction caused by dysregulation of host response caused by severe infection,which has become a prominent public health problem worldwide and one of the major diseases leading to patient death in the world.At present, the biomarkers commonly used to assist in the diagnosis of sepsis in clinical practice include procalcitonin (PCT), C-reactive protein (CRP) and peripheral white blood cells (WBC), but the above detection items have the disadvantages of time-consuming, labor-intensive and resource-consuming, it cannot quickly identify the cause of sepsis, and even delay the time for patients to receive effective treatment.As a new detection technology based on molecular level, Raman spectroscopy has the advantages of fast speed, high efficiency and strong specificity, which shows strong analytical potential and development space in rapidly identifying the cause of sepsis, it can provide many valuable molecular information for the auxiliary diagnosis and effective treatment of sepsis patients, and better help clinicians to make timely and effective management of them.In this paper, the research results of new molecular detection techniques in recent years are reviewed. 2021 Vol. 28 (29): 39-42 [Abstract] ( 39 ) HTML (38 KB)  PDF  (0 KB)  ( 8 ) 43 Clinical value of venous-arterial carbon dioxide partial pressure difference combined with venous oxygen saturation monitoring in patients with septic shock NI Shi-jiao  Objective To explore the clinical value of venous-arterial carbon dioxide partial pressure difference (P[cva]CO2) and venous oxygen saturation（ScvO2） monitoring in septic shock.Methods From October 2018 to October 2020,86 patients with septic shock admitted to Jingdezhen Second People′s Hospital, Jiangxi Province were selected as the research objects.They were divided into the control group （43 cases） and the treatment group （43 cases） using random number table method.Patients in the control group used ScvO2 level as the guiding target for fluid resuscitation, Pa tients in the treatment group used the individual ScvO2 level combined with P(cv-a)CO2 level as the guiding target for fluid resuscitation.Patients in both groups were continuously observed for 28 days after fluid resuscitation for 6 hours.the treatment of the two groups of patients, physiological indicators, lactic acid clearance rate and prognosis before fluid resuscitation and 6 hours after fluid resuscitation were compared.Results The length of stay in the treatment group was shorter than that of the control group, and the difference was statistically significant （P＜0.05）; the dosage of Nore pinephrine of the treatment group was less than that of the control group, and the difference was statistically significant（P＜0.05）.After 6 hours of resuscitation, the central venous pressure （CVP）, mean arterial pressure （MAP）, and ScvO2 levels of the two groups were higher than those before resuscitation, and the CVP, ScvO2 levels and lactate clearance rate of the treatment group were higher than those of the control group, and the differences were statistically significant（P＜0.05）.There was no statistically significant difference in MAP level between the two groups of patients after 6 hours of fluid resuscitation （P＞0.05）; the differences in the incidence of pulmonary edema and mortality within 28 days between the two groups were not statistically significant （P＞0.05）.Conclusion P（cv-a）CO2 combined with ScvO2 is used as a monitoring indicator to guide patients with septic shock to perform fluid resuscitation,which can effectively improve the quality of fluid resuscitation, improve the treatment effect, shorten the hospital stay, reduce the amount of related medications, and the incidence of pulmonary edema after fluid resuscitation no increase, good security. 2021 Vol. 28 (29): 43-45 [Abstract] ( 41 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 46 Effect of swallowing radiography combined with swallowing rehabilitation therapy on the rehabilitation of patients with dysphagia after stroke GUI Shun；WU He-hua Objective To investigate the effect of swallowing radiography combined with swallowing rehabilitation therapy on the rehabilitation of patients with dysphagia after stroke.Methods A total of 76 patients with dysphagia after stroke admitted to Fuzhou First People′s Hospital from April 2019 to October 2020 were selected as the research subjects.The patients were divided into the control group (n=38) and the observation group (n=38) according to random number table method.Patients in the control group were provided with swallowing rehabilitation therapy, and patients in the observation group were combined with X-ray dynamic iohexol swallowing angiography on the basis of swallowing rehabilitation therapy.The intervention time lasted two weeks.The swallowing function, the degree of aspiration and the overall incidence of complications were compared between the two groups.Results After the intervention, the swallowing function classification of the observation group was better than that of the control group, and the recovery rate was higher than that of the control group, with statistical differences (P＜0.05).Before the intervention, there was no significant difference in the aspiration degree score of the two groups (P＞0.05).After the intervention, the aspiration degree score and the overall incidence of complications in the observation group were lower than those in the control group,with statistical differences (P＜0.05).Conclusion Swallowing radiography combined with swallowing rehabilitation therapy can improve the rehabilitation effect of patients with dysphagia after stroke, reduce complications, which is worthy of clinical promotion. 2021 Vol. 28 (29): 46-48转52 [Abstract] ( 43 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 49 Application effect of intermittent oral tube feeding in patients with swallowing dysfunction ZHANG Chun-hua；FANG-Lu；OUYANG Hui；SHI Hui；ZHENG Wei-hong Objective To discuss the application effect of intermittent oral tube feeging in patients with swallowing dysfunction.Methods A total of 60 patients with chronic consciousness disorder and swallowing disorder admitted in Guangdong Industrial Injury Rehabilitation Hospital from January 2019 to December 2020 were selected and divided into the control group and the observation group according to random number table method, 30 cases in each group.The control group used conventional feeding method, the observation group was fed by intermittent feeding through oral tube,comparison of swallowing function of both groups(improved mann swallowing capacity assessment scale[MASA],fiber nasopharyngeal larynthroscopy swallowing function examination [FEES]), nutritional status (constitution index [BMI], triceps fold thickness [TSF], hemoglobin [Hb], the serum total protein [TP], albumin [ALB]), and complications.Results After treatment, the MASA, FEES score of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05).After treatment, the BMI, TSF, ALB, Hb, TP of the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05).The incidence of inhaled pneumonia in the observation group (3.33%) was lower than that of the control group (23.33%), the difference was statistically significant (P＜0.05).There were no significant differences between the incidence of diarrhea, constipation,hydroelectrolyte disorder and anxiety (P＞0.05).Conclusion Intermittent oral tube feeding is used in patients with swallowing dysfunction, which can improve their swallowing dysfunction and have high application value. 2021 Vol. 28 (29): 49-52 [Abstract] ( 45 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 53 Clinical effect of photodynamic therapy combined with CO2 laser in the treatment of cervical condyloma acuminatum patients with fertility needs WANG Ming；ZHENG Xia；HE Mei-hua；FAN Qing-qing；SHUAI Ci-dan；QIU Yue-ling；ZHANG Juan Objective To explore the clinical effect of photodynamic therapy combined with CO2 laser in the treatment of cervical condyloma acuminatum patients with fertility needs.Methods Sixty patients with cervix condyloma acuminata who had fertility needs admitted to the Jiangxi Provincial Dermatology Hospital from June 2019 to June 2020 were selected as the research objects.According to the random number table, they were divided into a control group(30 cases) and a study group (30 cases).The control group was treated with CO2 laser, and the study group was treated with photodynamic therapy on the basis of the control group.The clinical efficacy,human papilloma virus(HPV)clearance time, wound healing time, wound crusting time, total incidence and recurrence rate of adverse reactions, quality of life,and psychological status were compared between the two groups of patients.Results The total effective rate of the study group after treatment was higher than that of the control group, and the difference was statistically significant (P＜0.05).The HPV clearance time, wound healing time, and wound scab time of the study group were shorter than those of the control group,and the differences were statistically significant(P＜0.05).The total incidence and recurrence rate of adverse reactions in the study group were lower than those of the control group, and the differences were statistically significant(P＜0.05).Before treatment, there were no statistical differences between the two groups of dermatological quality of life index (DLQI) scores, Hamilton depression scale (HAMD) scores and Hamilton anxiety scale (HAMA) scores (P＞0.05);the DLQI score, HAMD score and HAMA score of the two groups after treatment were lower than those before treatment, and the study group was lower than that of the control group, the differences were statistically significant (P＜0.05).Conclusion Photodynamic therapy can effectively eliminate HPV in patients with cervical condyloma acuminata who need childbirth, promote wound healing, enhance curative effect, and have high safety, it can also effectively relieve negative emotions and improve their quality of life, the clinical effect is remarkable 2021 Vol. 28 (29): 53-55转59 [Abstract] ( 40 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 56 Effect of Cyclophosphamide combined with glucocorticoid in systemic lupus erythematosus LIU Ling；TANG Yan-hua；LIU Ju  Objective To explore the effect of Cyclophosphamide combined with glucocorticoid in systemic lupus erythematosus (SLE).Methods A total of 82 SLE patients treated in Jiujiang First People′s Hospital from March 2018 to March 2020 were divided into observation group and control group according to the random number table method, with 41 cases in each group.The control group was treated with Prednisone, and the observation group was treated with Cyclophosphamide on the basis of the control group.The clinical efficacy, serum cytokine level, immunoglobulin level and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).There were no significant differences in serum cytokine levels and immunoglobulin levels between the two groups before treatment (P＞0.05); after treatment, the interleukin-6 (IL-6), interleukin-10 (IL-10), interferon-α (IFN-α), immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05); after treatment, the levels of IL-6, IL-10, IFN-α, IgA, IgM, and IgG in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Cyclophosphamide combined with Prednisone can enhance the therapeutic effect of SLE, reduce the body′s inflammatory response, suppress excessive immune hyperactivity, stabilize the progression of the disease, and is safe and reliable. 2021 Vol. 28 (29): 56-59 [Abstract] ( 43 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 60 Application effect of endoscopic flow limiting embolization on patients with portal hypertension complicated with isolated gastric varices LIANG Bin；WANG Dong-mei； XIAO Mei；ZHOU Guan-lin；XU Fei；JIANG Man-lei1 YANG Zhi-jun1 HU Jiang-ling Objective To explore the application effect of endoscopic flow limiting embolization in patients with portal hypertension and isolated gastric varices (IGV).Methods A total of 50 patients with portal hypertension and IGV admitted to the Fifth People′s Hospital of Ganzhou between May 2018 and May 2019 were selected as the research subjects.According to the random number table method, they were divided into control group (25 cases) and observation group (25 cases).The control group was given sclerotherapy combined with tissue glue embolization, and observation group was treated with titanium clip flow restriction combined with sclerotherapy + tissue glue embolization.The portal blood flow status (diameter, flow velocity, flow volume) and liver function (alanine aminotransferase [ALT], total bilirubin [TBil], aspartate aminotransferase [AST]) of the two groups were compared before surgery and at 14 d after surgery.The mortality rate, disappearance rate of intragastric varicose veins and incidence rate of complications were compared between the two groups within 14, 30 and 90 d after surgery.Results At 14 d after surgery, the portal vein diameter of the two groups was longer than that before surgery, flow velocity was faster than that before surgery, and flow volume was higher than that before surgery, and the portal vein diameter of the observation group was longer than that of the control group, flow velocity of the observation group was faster than that of the control group, flow volume of the observation group was higher than that of the control group, the differences were statistically significant (P＜0.05).The levels of ALT, TBil, and AST in the two groups were lower than those before surgery, and the levels of observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).There were no statistically significant differences in the mortality rate between the two groups within 14, 30 and 90 d after surgery (P＞0.05).The incidence rate of complications in observation group was lower than that in control group, the disappearance rate of intragastric varicose veins was higher than that in control group, the differences were statistically significant (P＜0.05).Conclusion Endoscopic flow limiting embolization has a significant effect in the treatment of patients with portal hypertension and IGV.And it can not only effectively improve the portal vein blood flow and liver function, but also help reduce the occurrence of postoperative complications and improve the quality of life of patients, with high clinical application value. 2021 Vol. 28 (29): 60-63 [Abstract] ( 38 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 64 Clinical observation of topical application of Carteolol Eye Drops in treating infantile superficial hemangioma QIU Jian-wen；SHU Jian；WU Long-mao；LI Jian；LIU Yan-qing Objective To study the clinical effect of topical application of Carteolol Eye Drops in the treatment of infantile superficial hemangioma.Methods A total of 76 children with superficial hemangioma who were admitted to the Department of Dermatology, Maternal and Child Health Hospital of Ganzhou City from January 2018 to December 2019 were selected as the research subjects.The children were divided into 2 groups by the random number table method,38 cases in each group.The control group was treated with topical application of 5% Imiquimod Cream, and the observation group was treated with topical Carteolol Eye Drops.The treatment effect and the adverse reactions were compared between the two groups.Results After 6 months of treatment, the total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant （P＜0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups （P＞0.05）.Conclusion Carteolol Eye Drops for local topical treatment of infant superficial hemangioma have a definite clinical effect, can improve the cure rate, and have a low incidence of adverse reactions, and have high drug safety. 2021 Vol. 28 (29): 64-66转70 [Abstract] ( 46 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 67 Application effect of argon knife combined with urokinase injection under medical thoracoscope in treatment of patients with tuberculous encapsulated pleural effusion LUO Fu-yuan；LIU Zhi；JIE Fei-long；WANG Long  Objective To investigate the application effect of argon knife combined with urokinase injection under medical thoracoscope in treatment of patients with tuberculous encapsulated pleural effusion.Methods A total of 50 cases of patients with tuberculous encapsulated pleural effusion and who treated from April 2020 to April 2021 were selected as the research objects,and the patients were divided into control group (25 cases)and observation group (25 cases) according to the random number table method.The observation group was treated with argon knife combined with urokinase injection under medical thoracoscope, and the control group was treated with closed thoracic drainage combined with urokinase intrapleural injection.The treatment clinical effect, treatment indexes, pulmonary function and total complication rate of two groups were compared.Results The total effective rate in the observation group was higher than the control group, and the difference was statistically significant (P＜0.05).The disappearance time of pleural effusion, hospitalization time and drainage days in the observation group were shorter than those in the control group, the pleural thickness was smaller than that in the control group, and the total amount of fluid extraction was higher than that in the control group, with statistical significances (P＜0.05).There was no significant difference in lung function between the two groups before treatment (P＞0.05).After treatment, the FEV1/FVC of the two groups after treatment was higher than that before treatment, FVC was lower than that before treatment, the FVC in the observation group was lower than that in the control group, FEV1/FVC was higher than that in the control group, the differences were statistically significant (P＜0.05).There was no significant difference in the total complications rate between the two groups (P＞0.05).Conclusion The clinical treatment of tuberculous encapsulated pleural effusion can consider the use of medical thoracoscopic argon knife combined with urokinase injection, the improvement of pulmonary function is more significant, and which can reduce postoperative complications, promote the recovery of the disease, the clinical effect is ideal. 2021 Vol. 28 (29): 67-70 [Abstract] ( 41 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 71 Clinical effect of Probukol combined with Aspirin in the treatment of severe M1 segment stenosis of middle cerebral artery HUANG Wen-li；HONG Quan-long；WU Zhi-sheng；ZHU Zhi-hua；GONG Shu-jie Objective To investigate the clinical effect and safety of Probucol combined with Aspirin in the treatment of severe M1 segment stenosis of middle cerebral artery.Methods A total of 100 patients with severe M1-stenosis admitted to Quanzhou First Hospital Affiliated to Fujian Medical University from January 2017 to December 2019 were selected and divided into the control group and the experimental group according to random number table method, 50 cases in each group.The control group was given Aspirin treatment only, and the experimental group was given Probucol 0.5 g/time, bid, for 3 months on the basis of treatment in the control group.The M1 segment stenosis degree, lipid level and adverse drug reactions were compared between the two groups.Results The M1 stenosis degree of the experimental group was (62.03±2.15) %, low-density lipoprotein-cholesterol (LDL-C) was (2.37±0.17) mmol/L, triacylglycerol（TG） was (1.18±0.14) mmol/L, total cholesterol（TC） was (3.06±0.12) mmol/L and fibrinogen (FIB) was (2.34±0.34) g/L,respectively, lower than that of the control group of (71.85±2.77) %, (3.37±0.2) mmol/L, (2.09±0.12) mmol/L, (5.02±0.12) mmol/L and (3.88±0.23) g/L, high-density lipoprotein cholesterol (HDL-C) was (1.21±0.09) mmol/L, higher than that of the control group of (1.11±0.09) mmol/L, prothrombin time (PT) was (18.54±2.01） s, acti vatedpartial thromboplastin time (APTT) was (32.36±2.72）s, longer than tthat of the control group of (15.06±1.63) and (25.44±2.43) s, the differences were statistically significant (P＜0.05).Adverse drug reactions occurred in the two groups during treatment,including vomiting and abdominal distension in the experimental group and vomiting in the control group.There was no statistically significant difference in the incidence of adverse reaction (P＞0.05).Conclusion Probucol in the treatment of severe M1-segment of middle cerebral artery can significantly improve the degree of stenosis of middle cerebral artery，without increasing the incidence of adverse drug reactions. 2021 Vol. 28 (29): 71-73转77 [Abstract] ( 45 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 74 Effect comparison of Angiojet mechanical thrombus aspiration and catheter contact thrombolysis in the treatment of acute deep venous thrombosis of lower extremity OUYANG Liang-yuan；YANG Pu-gen； LIU jun Objective To compare the application effect of Angiojet mechanical thrombus aspiration and catheter contact thrombolysis in the treatment of acute deep venous thrombosis of lower extremity (DVT).Methods Fifty patients with acute lower extremity DVT who were admitted to Yichun People′s Hospital from January 2019 to January 2021 were selected as the research objects.According to the random number table method, they were divided into a control group and an observation group, with 25 cases in each group.The observation group was given Angiojet mechanical thrombus aspiration, and the control group was given catheter contact thrombolysis therapy.The effect of thrombolysis, thrombolysis time, length of hospital stay, dosage of urokinase and the total incidence of postoperative complications were compared between the two groups.Results The thrombolytic effect of the observation group was better than that of the control group, the difference was statistically significant (P＜0.05); the thrombolysis time, urokinase dosage and total hospital stay of the observation group were shorter than those of the control group, the differences were statistically significant (P＜0.05); the total incidence of postoperative complications was compared between the two groups, the difference was not statistically significant (P ＜0.05).Conclusion The Angiojet mechanical thrombus aspiration is better than catheter contact thrombolysis in the treatment of acute lower extremity DVT, which can reduce the length of hospital stay.It has the advantages of high venous patency, short thrombolysis time, and less urokinase dosage. 2021 Vol. 28 (29): 74-77 [Abstract] ( 39 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 78 Effect and safety of tension-free hernia repair surgery in the treatment of adult patients with inguinal hernia QIN Wei-jing；WANG Bin；QUAN Dong；CHANG Xin；LIU Xuan  Objective To explore the effect and safety of tension-free hernia repair surgery in the treatment of adult patients with inguinal hernia.Methods A total of 88 adult patients with inguinal hernia admitted to the No.63750 Hospital of the People′s Liberation Army from May 2016 to June 2020 were selected as the research objects.According to the surgical indications and patients′ wishes, they were divided into the observation group (n=63) and the control group(n=25).The observation group was treated with tension-free group, the control group was treated with laparoscopic hernia repair.The clinical therapeutic effect, total incidence of complications, operation time, intraoperative blood loss,hospitalization time, severity of pain and treatment cost of the two groups were compared.Results There was no statistically significant difference in the total effective rate between the two groups (P>0.05); there was no statistically significant difference in the total incidence rate of complications between the two groups (P>0.05); there were no statistically significant differences in the duration of surgery, intraoperative blood loss, length of hospital stay and VAS scores between the two groups (P>0.05); there was no statistically significant difference in the treatment cost between the two groups (P>0.05).Conclusion Compared with laparoscopic hernia repair, tension-free repair has no significant differences in complications, blood loss, and recurrence rate.The clinical effect is similar, the length of surgery will not be significantly increased, the cost of treatment will no incur higher, and the surgery is relatively simple.Therefore, it is suitable for continued popularization and application in clinical practice, especially in primary hospitals. 2021 Vol. 28 (29): 78-80 [Abstract] ( 39 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 81 Effect of Simo Decoction and Tianshu acupoint massage on preventing abdominal distension after lumbar spine fracture operation LIU Su-yun；LI Yun-li；TANG Fen-fen Objective To explore the effect of Simo Decoction combined with massage at Tianshu acupoint in treating abdominal distension after lumbar fracture.Methods A total of 162 patients with lumbar fractures who underwent surgery in the Department of Orthopedics, the Second Affiliated Hospital of Nanchang University from July 2018 to December 2019 were selected.All patients were accompanied by abdominal distension after surgery.They were randomly divided into Simo Decoction group, massage Tianshu acupoint group and combined group, with 54 cases in each group.Simo Decoction group was given Simo Decoction oral liquid treatment.Massage Tianshu acupoint group was treated with Tianshu acupoint massage.The combined group was treated with Simo Decoction oral liquid combined with massage at Tianshu acupoint.The first exhaust time, the first defecation time, the total effective rate and treatment satisfaction score after 4 weeks of treatment, and the incidence of adverse reactions during treatment in the three groups were compared.Results After 4 weeks of treatment, the first exhaust time and the first defecation time in the combined group were shorter than those in the Simo Decoction group and Tianshu massage group, the differences were statistically significant (P＜0.017); the combined group always had 4 weeks of treatment the efficiency and satisfaction of treatment were higher than those of Simo Decoction group and Tianshu acupoint massage group, the differences were statistically significant (P＜0.017); the total incidence of adverse reactions among the three groups was not statistically significant (P＞0.05).Conclusion The combination of Simo Decoction and Tianshu acupoint massage is effective in preventing postoperative abdominal distension of lumbar vertebral fractures, effectively improving the efficiency of diagnosis and treatment and patient satisfaction, and it is worthy of clinical application. 2021 Vol. 28 (29): 81-84 [Abstract] ( 50 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 85 Clinical effect of Synovitis Granules combined with Sodium Hyaluronate Injection in the treatment of knee osteoarthritis complicated with synovitis WU Tian-lin；WANG Wei-Jia；ZHANG Luan-di；CHEN Xiu-juan；LI Chang-Ning Objective To investigate the clinical effect of Synovitis Granules combined with Sodium Hyaluronate Injection in the treatment of knee osteoarthritis (KOA) combined with synovitis.Methods A total of 60 patients with KOA complicated with synovitis admitted to the Third People′s Hospital Affiliated to Fujian University of Chinese Medicine from July 2019 to July 2020 were selected as the research subjects, and they were divided into control group and treatment group according to random number table method, with 30 cases in each group.The control group was injected with Sodium Hyaluronate, and the treatment group was injected with Sodium Hyaluronate + Synovitis Granules orally.The treatment effect, visual analogue scale (VAS) score and joint swelling degree before and after treatment were compared between the two groups.Results The total effective rate of the treatment group was 83.3%, higher than that of the control group (76.7%), and the difference was statistically significant (P＜0.05).Before treatment, there was no significant difference in VAS score and knee swelling score between two groups (P＞0.05).After treatment, VAS score and knee swelling score in the two groups were lower than before, and VAS score and knee swelling score in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05).Conclusion The combination of Synovitis Granules and Sodium Hyaluronate has a significant effect on the treatment of KOA combined with synovitis, which has clinical promotion value. 2021 Vol. 28 (29): 85-87 [Abstract] ( 51 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 88 Application value of pain intervention in digital flexor tendon microrepair LI Guan-jun；WU Mei-yi；QIU Hui；YANG Di； LIU Yong-ming Objective To investigate the application value of pain intervention in flexor digitorum tendon microrepair.Methods A total of 114 patients with digital flexor tendon injury admitted to the Seventh Affiliated Hospital, Southern Medical University from May 2017 to July 2019 were selected as the research subjects, and they were divided into study group (57 cases) and control group (57 cases) according to random number table method.Both groups of patients were treated with microsurgery, the control group was given conventional intravenous anesthesia, and the study group received intermuscular brachial plexus block after operation on the basis of the control group.The pain visual analog scale (VAS) scores, rehabilitation effect, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and complications of the two groups were compared.Results The VAS scores of the study group at 1, 2, and 4 weeks after operation were lower than those of the control group, and the differences were statistically significant (P＜0.05).After treatment, the levels of IL-6 and TNF-α in the two groups were lower than those before treatment, and the study group was lower than that in the control group, the differences were statistically significant (P＜0.05).The good prognosis rate of the study group was 98.2%, which was higher than 87.7% of the control group, and the difference was statistically significant (P＜0.05).The total incidence of complications in the study group was 3.5%, which was lower than 17.5% in the control group, and the difference was statistically significant (P＜0.05).Conclusion The application of pain intervention after micro-repair of finger flexor tendon can promote pain relief, reduce the occurrence of complications, and improve the excellent and good rate of patients' total active mobility. 2021 Vol. 28 (29): 88-90 [Abstract] ( 44 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 91 Clinical effect of pedicled fascia flap combined with free skin graft instead of free skin flap in the treatment of exposed bone and tendon wounds HUANG Mou-zhang；GUO Jiu-sheng；ZHU Xiao-rong Objective To explore the clinical effect of pedicled fascia flap combined with free skin graft instead of free skin flap in the treatment of bone and tendon exposed wounds.Methods A total of 60 patients with exposed bone and tendon wounds admitted to the Department of Emergency Traumatology of Ganzhou People′s Hospital from March 2020 to February 2021 were selected as the research objects, and were divided into a control group (30 cases) and an observation group (30 cases) according to a random number table method.The control group was treated with the traditional fascia flap with the flip technique, and the observation group was treated with the pedicled fascia flap with the roll technique combined with free skin graft instead of free flap.Wound infection rate, skin graft survival rate, wound healing rate and visual analog scale (VAS) score were compared between the two groups.Results The wound healing rate(73.33%) and skin graft survival rate (90.00%) in the observation group were higher than those in the control group(36.67% and 50.00%), and the wound infection rate in the observation group (3.33%) was lower than that in the control group (26.67%), the differences were statistically significant (P＜0.05).Preoperative comparison of VAS scores between the two groups showed no statistical significance (P＞0.05).After surgery, VAS scores of the two groups were lower than those before surgery, and VAS score of the observation group was lower than that of the control group, the difference was statistically significant (P＜0.05).Conclusion For patients with exposed bone and tendon wounds, the combined treatment of pedicled fascia flaps and free skin grafts with the rolling technique is effective.It can reduce the infection rate of the wound, increase the survival rate of the skin graft and the rate of one-time wound healing, reduce pain, and the clinical application value is outstanding. 2021 Vol. 28 (29): 91-93转97 [Abstract] ( 41 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 94 Biomechanical comparison between interlocking suture and semi-knot locking suture in tendon repair BAI Qing-bing；DONG Li-yuan；WANG Hong-qing；MA Tian-xiao； HU Yu-qing； WANG Dong-yue； ZHAO Shuming； SONG Li-hua  Objective To explore the biomechanical comparison between interlocking suture and half-knot locking suture in tendon repair.Methods A total of 130 flexor digitorum profundus tendons in the hind limbs of 65 adult white pigs weighing 300-400 g were selected as experimental subjects, and were divided into control group (65 tendons) and study group (65 tendons) according to random number table method.The control group was treated with half knot locking suture, while the study group was treated with internal locking suture.The suture time, 2 mm crack formation load,maximum tensile strength, maximum gap, and suture detachment fracture condition were compared between the two groups.Results There was no significant difference in suture time between the two groups (P＞0.05).The formation load of 2 mm crack in the study group was higher than that in the control group, the maximum tensile strength was higher than that in the control group, and the maximum gap length was longer than that in the control group, with statistically significant differences (P＜0.05).The fracture mode in the control group was suture line segment fracture, and in the study group, suture line was pulled from the broken end of tendon.Conclusion Compared with semi-knot locking suture, interlocking suture has better biomechanical properties and can effectively prevent gap formation, which is worth popularizing. 2021 Vol. 28 (29): 94-97 [Abstract] ( 50 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 98 Application of immunohistochemical staining indexes of cytokeratin 5/6,P63 protein, cytokeratin 7, thyroid transcription factor 1 in the differential diagnosis of non-small cell lung cancer LI Fei-mei； WANG Wu-ming；ZHAO Long Objective To study the effect of immunohistochemical staining indexes of cytokeratin 5/6, P63 protein, cytokeratin 7 and thyroid transcription factor 1 in the diagnosis of non-small cell lung cancer.Methods From October 2018 to October 2020, 40 cases of bronchoscopic biopsy of lung lesions of patients with non-small cell lung cancer and 40 cases of bronchoscopic biopsy of lung lesions of patients with chronic obstructive pulmonary disease confirmed by treatment in Jiangxi Chest Hospital were selected, and 40 cases of bronchoscopic biopsy of normal lung tissue of patients were selected, which were divided into the study group 1, the study group 2 and the control group.Immunohistochemical staining was used to detect the positive expression of cytokeratin 5/6, P63 protein, cytokeratin 7 and thyroid transcription factor 1 in the three groups, and the detection results of the four indexes of cytokeratin 5/6, P63 protein,cytokeratin 7 and thyroid transcription factor 1 were compared among the three groups.Results The positive expression rates of cytokeratin 5/6, P63 protein, cytokeratin 7 and thyroid transcription factor 1 in the study group 1 were higher than those in the study group 2, the differences were statistically significant (P＜0.05).The positive expression rates of cytokeratin 5/6, P63 protein, cytokeratin 7 and thyroid transcription factor 1 in the study group 2 were higher than those in the control group, the differences were statistically significant (P＜0.05).Conclusion The positive expression rate of cytokeratin 5/6, P63 protein, cytokeratin 7 and thyroid transcription factor 1 in patients with non-small cell lung cancer are significantly higher than those in patients with chronic obstructive pulmonary disease and healthy people,which can be used as an important basis for screening and diagnosis of non-small cell lung cancer. 2021 Vol. 28 (29): 98-100 [Abstract] ( 41 ) HTML (30 KB)  PDF  (0 KB)  ( 4 ) 101 Influence of community free diagnosis combined with medical follow-up management mode on early screening of tumor CHEN Ying-fang；WAN Min；ZHONG Hong-xia；YAN Rui-ying；TAN Qi-you Objective To explore the application effect of community free diagnosis combined with medical follow -up management mode in improving the early screening rate of tumor patients.Methods A total of 120 tumor high-risk groups who organized regular community cancer free diagnosis activities in the Cancer Center of Ganzhou Municipal Hospital of Jiangxi Province from January to December 2020 were selected as the research objects.Among them, 60 patients who voluntarily joined the medical follow-up platform were set as the observation group, and carried out disease tracking, evaluated the progress of the disease, selected the best treatment time according to the actual situation, and formulated diagnosis and treatment prescriptions for it.The remaining 60 high-risk groups were set as the control group, and received routine management.The early diagnosis rate, the cure rate and the degree of patient satisfaction were compared between the two groups.Results The early diagnosis rate (93.33%) and the cure rate (83.93%) of tumor in the observation group were higher than those in the control group (53.33%, 25.00%), and the differences were statistically significant (P＜0.05).The degree of satisfaction scores of community free diagnosis, medical follow-up management and diagnosis and treatment in the observation group were all higher than those in the control group, with statistical significance (P＜0.05).Conclusion The mode of community free diagnosis combined with medical follow-up management can significantly improve the early screening and the diagnosis rate of high-risk groups of tumor, as well as the cure rate.It is a good mode for early screening of tumor patients. 2021 Vol. 28 (29): 101-103 [Abstract] ( 31 ) HTML (29 KB)  PDF  (0 KB)  ( 5 ) 104 Effect of laparoscope assisted radical gastrectomy in the treatment of gastric cancer ZHANG Xiao-yong；PENG Peng；XU He-feng Objective To investigate the effect of laparoscope assisted radical gastrectomy in the treatment of gastric cancer.Methods A total of 50 patients with gastric cancer in Xinyu People′s Hospital from January 2017 to December 2018 were selected and divided into the observation group and the control group by random number table method, with 25 cases in each group.The observation group received laparoscope assisted radical gastrectomy, and the control group received open radical gastrectomy.The surgical conditions, preoperative and postoperative stress response, intestinal barrier function, immune level and the incidence of complications were compared between the two groups.Results The amount of intraoperative blood loss in the observation group was less than that in the control group, and the incision length and hospitalization time in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05).There was no significant difference in the operation time between the two groups (P＞0.05).Before operation, there were no significant differences in the levels of endothelin, interleukin-6 and C-reactive protein between the two groups (P＞0.05).The levels of endothelin, interleukin-6 and C-reactive protein in the observation group at the fifith days after operation were lower than those in the control group, with statistical significances (P＜0.05).There were no significant differences in the levels of plasma D-lactic acid and diamine oxidase between the two groups before operation (P＞0.05).After operation at the fifth days, the levels of plasma D-lactic acid and diamine oxidase in the observation group were lower than those in the control group, with statistical significance (P＜0.05).Before operation, there were no significant differences in the levels of plasma CD3+, CD4+, CD8+, CD4+/CD8+ between the two groups (P＞0.05).After operation at the fifth days, the levels of plasma CD3+, CD4+and CD4+/CD8+ in the observation group were higher than those in the control group, the level of plasma CD8+ in the observation group was lower than that in the control group, the differences were statistically significant (P＜0.05).The incidence of complications in the observation group was 28.00% (7/25), which was lower than 48.00% (12/25) in the control group, and the difference was statistically significant (P＜0.05).Conclusion Laparoscope in the treatment of gastric cancer can effectively shorten the length of hospital stay, reduce blood loss, reduce the body′s stress response, increase the level of immunity of patients after surgery, reduce the intestinal barrier function during surgery and reduce the incidence of complications. 2021 Vol. 28 (29): 104-107 [Abstract] ( 42 ) HTML (38 KB)  PDF  (0 KB)  ( 8 ) 108 Effect comparison of breast-conserving and modified radical surgery in the treatment of breast cancer ZHAO Yin-ming Objective To investigate the effect of breast-conserving and modified radical surgery in the treatment of breast cancer and its influence on the quality of life.Methods From January 2018 to January 2020,a total of 100 patients with breast cancer admitted to Beijing Jingmei Group General Hospital were retrospectively selected as the research objects, and they were divided into the control group (50 cases) and the intervention group (50 cases) according to different surgical methods.The control group adopted the breast-conserving surgery method, and the intervention group adopted the modified radical surgery method.The surgical indicators (intraoperative blood loss, incision length, operation time, hospital stay), cosmetic effect, postoperative survival rate, the recurrence rate and the quality of life between the two groups were compared.Results The amount of intraoperative blood loss in the intervention group was less than that in the control group, and the incision length, operation time, and hospital stay in the intervention group were shorter than those in the control group, the differences were statistically significant (P＜0.05).The excellent and good rate of surgical beauty in the intervention group was higher than that of the control group, the difference was statistically significant (P＜0.05).After 1 year of follow-up, there were no recurrences in the two groups and all patients survived.The quality of life score of the intervention group was higher than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion Breast-conserving surgery and modified radical mastectomy are effective in treating breast cancer, and there is no significant difference.Breast-conserving surgery is beneficial to the breast beauty of patients, relieves their physical and psychological discomfort, and improves their quality of life.It is worthy of popularization and application. 2021 Vol. 28 (29): 108-110 [Abstract] ( 44 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 111 Study on the correlation between the level of glycolipid and small molecule metabolites in gestational diabetes YUAN Zhen；HUANG Mei-ling；ZHANG Wei Objective To investigate the correlation between the level of glycolipid and small molecule metabolites in gestational diabetes mellitus (GDM).Methods Twenty patients with GDM admitted to Yichun People′s Hospital from January 2019 to August 2020 were selected as the observation group, and twenty normal pregnant women who were screened in Yichun People′s Hospital during the same period were selected as the control group.Compare the two groups of small molecule metabolites (tryptophan [Trp], tyrosine [Tyr]), glucose and lipid metabolism indicators (glycated hemoglobin [HbA1c], total cholesterol [TC], triglycerides [TG], high-density lipids Protein cholesterol [HDL-C] and low-density lipoprotein cholesterol [LDL-C]) levels.Pearson was used to analyze the correlation between Trp, Tyr and glucose and lipid metabolism indicators.Results The level of the Trp, Tyr, HDL-C of the observation group were lower than those of the control group, and the level of the HbA1c, TC, TG, LDL-C of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05).The level of the Trp, Tyr were compared with the level of the HDL-C were positively correlated (r=0.496, 0.485, P＜0.05).The levels of the Trp and Tyr were correlated with the levels of the HbA1c (r=-0.452, -0.416, P＜0.05), TC (r=-0.432, -0.405, P＜0.05), TG (r=-0.558,-0.454, P＜0.05), LDL-C (r=-0.514, -0.427, P＜0.05) were negatively correlated.Conclusion There is correlation between the level of GDM glycolipid and small molecule metabolites.Small molecule metabolites may be involved in the abnormal process of GDM glycolipid metabolism. 2021 Vol. 28 (29): 111-113 [Abstract] ( 31 ) HTML (28 KB)  PDF  (0 KB)  ( 6 ) 114 Research and application of lithotomy position footrest in neonates CAI Jie；YANG Shu-qin；LIU Jia； LI Zhen；YANG Qiong  Objective To explore the application effect of lithotomy position footrest in neonatal surgeries.Methods A total of 35 neonates who underwent anorectal surgery in the First Affiliated Hospital of Gannan Medical University from January 2017 to December 2018 were selected as the research objectives,and divided into the routine group(18 cases)and the study group (17 cases) according to the random number table method.During the surgery, the routine group were given lower limb suspension, and the study group were given lithotomy position footrest.The length of posture, scope of surgical field, skin integrity, and degrees of satisfaction of surgeons and family members were compared between the two groups.Results The length of posture in the study group was shorter than that in the routine group, and the difference was statistically significant (P＜0.05).The scope of surgical field in the study group was clearer than that in the routine group, and the difference was statistically significant (P＜0.05).The total incidences of skin redness, strangulation,and peripheral circulatory disorders in the study group were lower than those in the conventional group, and the differences were statistically significant(P＜0.05).The degrees of satisfaction of surgeons and family members in the study group were higher than those in the conventional group, and the differences were statistically significant (P＜0.05).Conclusion The application of lithotomy position footrest can shorten the length of posture, improve the clarity of surgical field, ensure the integrity of skin in neonatal surgeries, with high degrees of satisfaction of surgeons and family members. 2021 Vol. 28 (29): 114-117 [Abstract] ( 37 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 118 Influence of episiotomy and natural laceration on pelvic floor function of primipara after natural childbirth WANG Ying；SUN Bei；SUN Lin；LI Hai-ying Objective To explore the influence of episiotomy and natural laceration on pelvic floor function of primipara after natural delivery.Methods The clinical data of 68 primiparas with natural childbirth in Dalian Women and Children Medical Center from August 2019 to August 2020 were retrospectively analyzed.They were divided into the lateral episiotomy group (34 cases) and the natural perineal laceration group (34 cases) according to different midwifery methods.Episiotomy was performed in the lateral episiotomy group, and perineal laceration occurred in the natural perineal laceration group.The pelvic floor function, perineal pain, pelvic floor myoelectric value, sexual function and complications of the two groups at 42 days after delivery were compared.Results There was no significant difference in pelvic floor function between the two groups (P＞0.05).The visual analogue scale (VAS) score of the lateral episiotomy group was higher than that of the natural perineal laceration group, and the pelvic floor myoelectric value of the lateral episiotomy group was lower than that of the natural perineal laceration group, the differences were statistically significant (P＜0.05).The scores of sexual arousal, vaginal lubrication, orgasm and sexual life satisfaction of the female sexual function index (FSFI) in the lateral episiotomy group were lower than those in the natural laceration group, the differences were statistically significant (P＜0.05).The total incidence of complications in the lateral episiotomy group was 26.47%, which was higher than 5.88% in the natural laceration group, the difference was statistically significant (P＜0.05).Conclusion Lateral episiotomy can prevent severe perineal laceration caused by natural childbirth, but it is more likely to damage basin muscles and nerves of primipara than natural perineal laceration, aggravate perineal wound pain,and reduce the quality of sexual life.Prenatal examination should be carried out for primipara to avoid hand abuse affecting patients′ physical and mental health. 2021 Vol. 28 (29): 118-120转124 [Abstract] ( 42 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 121 Influence of comprehensive nutritional meal and diet management on parturient labor process and delivery outcome LUO Ai-xiang；XIAO Wen-ping； LI Mei Objective To explore the influence of comprehensive nutritional meal and diet management on parturient labor process and delivery outcome.Methods From December 2019 to December 2020, a total of 68 pregnant women who planned to deliver vaginally, admitted to Ganzhou Maternity and Child Health Hospital from December 2019 to December 2020 were selected as the research subjects, and they were divided into the control group (34 cases) and the observation group (34 cases) according to the random number table method.The control group used voluntary diet or no diet, and the observation group used comprehensive nutritional meal and diet.The time of each stage of labor, the amount of bleeding in the 2 h postpartum, the intensity of uterine contractions, and the outcome of delivery were compared between the two groups.Results The total stage of labor and the second stage of labor in the observation group were shorter than those in the control group, the amount of bleeding in the 2 h postpartum in the observation group was less than that in the control group, the intensity of uterine contractions in the observation group was stronger than that in the control group, and the smooth delivery rate in the observation group was higher than that in the control group,and the differences were statistically significant (P＜0.05).The incidence of transition to cesarean section due to fatigue of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion The implementation of diet management during childbirth and delivery process helps to improve the labor process and delivery outcome of the parturient. 2021 Vol. 28 (29): 121-124 [Abstract] ( 40 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 125 Application of single-port transumbilical laparoscopic surgery with simple approach in gynecological benign lesions WU Xia-yun；LIU Yi-en；LI Lv-rong；FENG Jian-yi；HE Jun-yi；LIANG Wei-yan Objective To investigate the application of single-port transumbilical laparoscopic surgery with simple approach in gynecological benign lesions.Methods A total of 64 patients with gynecological benign lesions treated in Yangdong District People′s Hospital of Yangjiang City, Guangdong Province from May 2019 to February 2021 were selected as the research objects.By random number table method, they were divided into the observation group (30 cases)and the control group (34 cases).The observation group was treated by single-port transumbilical laparoscopic surgery with simple self-made approach.The control group received conventional perforated laparoscopic surgery.The operative time, intraoperative blood loss, visual analogue scale (VAS) scores 24 hours after surgery, postoperative hospital stay,postoperative umbilical incision complications were compared between the two groups.Results There were no statistically significant differences in operative time, intraoperative blood loss, VAS scores 24 hours after surgery, postoperative hospital stay, total incidence of postoperative umbilical incision complications between the two groups (P＞0.05).Conclusion It is safe and feasible to treat benign gynecological diseases with single-port transumbilical laparoscopic surgery with simple approach, which is suitable for clinical promotion at the primary level. 2021 Vol. 28 (29): 125-128 [Abstract] ( 39 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 129 Correlation between maternal serum vitamin A and E levels and the onset of preeclampsia XIAO Yu-xia；CHEN Shang-ping；YANG Xiao-hai Objective To explore the correlation and clinical significance of serum vitamin A and E levels in pregnant women with the severity of preeclampsia.Methods A total of 113 pregnant women who came to the Department of Obstetrics in People′s Hospital of Maoming City for treatment with preeclampsia from March 2018 to January 2020 were selected as the research subjects, and they were divided into mild preeclampsia group (69 cases) and severe preeclampsia group (44 cases) according to their severity.A total of 113 healthy people who came to People′s Hospital of Maoming City during the same period were selected as the control group.The serum levels of vitamin A and vitamin E in the three groups were compared, and the correlation with severity of preeclampsia was analyzed.Results The vitamin A and E of the severe preeclampsia group were lower than those of the mild preeclampsia group and the control group, and the differences were statistically significant (P＜0.05).The vitamin A and E of the mild preeclampsia group were lower than those of the control group, and the differences were statistically significant (P＜0.05).Vitamin A and E were negatively correlated with sevrity of preeclampsia (P＜0.05).Conclusion Serum vitamin A and E levels of pregnant women are significantly correlated with the severity of preeclampsia.Reasonable supplementation of vitamin A and E can effectively prevent or reduce the occurrence of preeclampsia and ensure the health of mothers and babies 2021 Vol. 28 (29): 129-131 [Abstract] ( 40 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 132 Effect of different maintenance doses of Caffeine Citrate on the treatment of apnea and the early -stage brain electrical activities among very preterm infants with primary apnea YANG Mei-Jun Objective To investigate the effect of different maintenance doses of Caffeine Citrate on the treatment of apnea and the early-stage brain electrical activities among very preterm infants with primary apnea.Methods A total of 56 cases of very preterm infants with primary apnea and administered by Fujian Provincial Hospital from January 2018 to December 2019 were selected as the research objects and divided into the observation group and the control group by random number table method, with 28 cases in each group.The two groups both received the conventional treatment combined with the caffeine citrate treatment.The maintenance dose of Caffeine Citrate was 10 mg/(kg·d) for the observation group and 5 mg/(kg·d) for the control group.Both groups were suspended from taking the drug after symptoms of apnea disappeared for seven days.The treatment effect, adverse reactions and complications, and amplitude integrated electroencephalogram (aEEG) maturity score were compared between the two groups.Results After 48 h of treatment,the number of apnea attacks in the observation group was less than that in the control group, the duration of mechanical ventilation, oxygen inhalation and caffeine treatment were shorter than those in the control group, and the aEEG maturity score adjusted for gestational age of 34, 36 and 40 weeks were higher than those in the control group, and the differences were statistically significant (P＜0.05).There were no statistically significant differences in the total incidence of adverse reactions and complications between the two groups (P＞0.05).Conclusion When the maintenance dose of caffeine citrate was 10 mg/(kg·d), the primary apnea symptoms of very preterm infants could be better alleviated, the maturity of brain electrical activities could be promoted, and the occurrence rate of adverse reactions and complications demonstrated no obvious increase. 2021 Vol. 28 (29): 132-135 [Abstract] ( 42 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 136 Application effect of Ropivacaine combined with Sufentanil epidural anesthesia in painless labor HUANG Ci-bin；ZHUANG Xiu-e；ZHENG Bin-yao；XIAO Quan-sheng Objective To investigate the effect of Ropivacaine combined with Sufentanil epidural anesthesia, labor process and stress response in parturients with painless delivery.Methods From January 2020 to January 2021, a total of 100 delivery women diagnosed and treated in Quanzhou Women′s and Children′s Hospital were selected as the research objects, and divided into the control group (50 cases) and the study group (50 cases) according to the random number table method.The control group was treated with Ropivacaine epidural anesthesia, and the study group was treated with Ropivacaine combined with Sufentanil epidural anesthesia.The anesthesia effect, stress response and labor process were compared between the two groups.Results The total effective rate of anesthesia in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The first stage, second stage,third stage and hospital stay of the study group were shorter than those in the control group, and the differences were statistically significant (P＜0.05).There was no statistically significant difference in the stress response indexes of the two groups of patients before delivery (P＞0.05).The cortisol (COR) and blood glucose (Glu) of the study group after delivery were lower than those of the control group after delivery, the differences were statistically significant (P＜0.05).Conclusion The application of Ropivacaine combined with Sufentanil epidural anesthesia to parturients in painless delivery could reduce the impact of stress response, shorten the course of parturients, and have a significant clinical anesthesia effect. 2021 Vol. 28 (29): 136-138 [Abstract] ( 47 ) HTML (29 KB)  PDF  (0 KB)  ( 7 ) 139 Effect comparison of two different artificial lacrimal duct in the treatment of lacrimal canaliculus rupture WANG Ting；JIANG Yan-hua Objective To compare the clinical effect of two different types of artificial lacrimal duct in the treatment of lacrimal canaliculus rupture.Methods Clinical data of 367 patients (367 eyes) who underwent lacrimal duct rupture and anastomosis combined with artificial lacrimal duct implantation in the Ophthalmological Lacrimal duct ward of the Fourth People′s Hospital of Shenyang City from January 2015 to October 2019 were retrospectively analyzed.According to different treatment methods, they were divided into RS artificial lacrimal duct group (182 cases) and LY-Fr3 artificial lacrimal duct group (185 cases).Patients in both groups were extubated 9 months after surgery, followed up for 3 months after extubation, and the operative time, surgical effect and surgical complications were compared between the two groups.Results The operative time of RS artificial lacrimal duct group was shorter than that of LY-Fr3 artificial lacrimal duct group, and the difference was statistically significant (P ＜0.05).There was no statistically significant difference in the total effective rate between the two groups (P＞0.05).The total incidence of complications in RS artificial lacrimal duct group was lower than that in LY-Fr3 artificial lacrimal duct group, and the difference was statistically significant (P＜0.05).Conclusion Both types of artificial lacrimal duct anastomosis surgery in the treatment of lacrimal canal fracturehave high success rate, but the RS artificial lacrimal duct has more advantages.It does not interfere with the nasal cavity of patients, shortens the operation time, reduces the pain of patients, has less postoperative complications and simple tube drawing.It is an ideal support for patients′ lacrimal duct rupture, and is worthy of clinical promotion. 2021 Vol. 28 (29): 139-141转145 [Abstract] ( 50 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 142 Application effect of vitrectomy in diabetic retinopathy CHEN Feng Objective To investigate the application effect of vitrectomy in diabetic retinopathy.Methods From January 2017 to June 2019, 80 patients with diabetic retinopathy (80 eyes) in the Department of Ophthalmology from Jingdezhen No.1 People′s Hospital were selected as the study subjects.They were divided into control group (40 cases, 40 eyes)and experimental group (40 cases, 40 eyes) by random number table grouping method.The experimental group was given vitrectomy, and the control group was given retinal laser.The intraocular pressure, best corrected visual acuity at each time period and postoperative complications were compared between the two groups.Results There were no significant differences in intraocular pressures between the two groups before operation, 1 day, 1 week and 1, 3 and 6 months after operation (P＞0.05).The intraocular pressures of the two groups at 1 week after operation were higher than those before operation, and the differences were statistically significant (P＜0.05).The best corrected visual acuity of the two groups at 3 months after operation was lower than that before operation, and the difference was statistically significant (P＜0.05).The best corrected visual acuity at 3 months after operation in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05).The total incidence of postoperative complications in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The clinical treatment effect of the vitrectomy is significant, which can reduce the best corrected visual acuity, reduce postoperative complications, and does not affect the postoperative intraocular pressure of patients with ophthalmic diabetic retinopathy.Therefore, this method is worthy of popularization. 2021 Vol. 28 (29): 142-145 [Abstract] ( 47 ) HTML (33 KB)  PDF  (0 KB)  ( 9 ) 146 Comparison of oral ulcer effect between internal and external use of Zhongtongan and Zhongtongan combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel ZHANG Qiu-fang；LAN Xu；LUO Xin-nian Objective To compare the effect of internal and external use of Zhongtongan and Zhongtongan combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel in the treatment of oral ulcer.Methods A total of 78 patients with oral ulcer admitted to Ganzhou People′s Hospital of Jiangxi Province from June 2019 to June 2020 were selected as the research subjects, and they were divided into group A and group B according to odd and even grouping method, with 39 cases in each group.Group A took Zhongtongan orally and used Recombinant Bovine Basic Fibroblast Growth Factor Gel externally, while group B took Zhongtongan orally and used Zhongtongan powder externally.Therapeutic effect, pain degree, area and number of oral ulcer before and after treatment were compared between the two groups.Results There was no statistically significant difference in the total effective rate between the two groups (P＞0.05).Before treatment, there was no statistically significant difference in visual analogue scale (VAS) score between the two groups (P＞0.05).After treatment, the VAS scores of the two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05).After treatment, the VAS score of the group B was lower than that of the group A, and the difference was statistically significant (P＜0.05).Before treatment, there were no statistically significant differences in area and number of ulcers between the two groups (P＞0.05).After treatment, the area and number of ulcers in the two groups were smaller than those before treatment, and the differences were statistically significant (P＜0.05).After treatment, the area and number of ulcers in the group B were smaller than those in the group A, and the differences were statistically significant (P＜0.05).Conclusion Zhongtongan combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel and internal and external use of Zhongtongan are both effective in treating oral ulcers, but internal and external use of Zhongtongan is more effective in reducing pain and controlling ulcers. 2021 Vol. 28 (29): 146-148 [Abstract] ( 40 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 149 Curative effect of Compound Chlorhexidine Gargle combined with Tinidazole on periodontal disease LIU Lei  Objective To investigate the therapeutic effect of compound Chlorhexidine Gargle combined with Tinidazole on periodontal disease.Methods A total of 70 patients with periodontal disease admitted to Diaobingshan People,s Hospital of Liaoning Province from January 2019 to January 2020 were selected as the research subjects, and were divided into observation group (35 cases) and control group (35 cases) according to random number table method.The observation group was treated with Compound Chlorhexidine Gargle combined with Tinidazole, while the control group was treated with Tinidazole, both groups were treated for 4 weeks.Oral health impact profile (OHIP-14) score, inflammatory factors, visual analogue scale (VAS) score, tooth looseness, gingival index, plaque index, periodontal attachment index,treatment effect and adverse reactions were compared between the two groups.Results The OHIP-14 score of the observation group after treatment was higher than that of the control group, the difference was statistically significant (P＜0.05).After treatment, the levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor -α (TNF-α)and matrix metalloproteinase-3 (MMP-3) in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).After treatment, VAS score, tooth looseness, gingival index, plaque index and periodontal attachment index in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).The total effective rate of observation group was higher than control group, and the difference was statistically significant (P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion Compound Chlorhexidine Gargle combined with Tinidazole can effectively control the inflammation of periodontal disease, improve the quality of life of periodontal patients and periodontal patients, with definite curative effect, which is worthy of promotion. 2021 Vol. 28 (29): 149-152 [Abstract] ( 57 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 153 Research on the relationship between urinary red blood cell morphology and traditional Chinese medinine syndrome types in patients with purpuric nephritis LUO Li-yuan；ZHONG Ying-chao；XIE Yue-heng；ZHONG Hua-wen Objective To observe the relationship between urinary red blood cell morphology and traditional Chinese medinine (TCM) syndrome types in patients with purpuric nephritis.Methods A total of 100 patients with purpuric nephritis in Yangjiang Hospital of Traditional Chinese Medicine from August 2020 to March 2021 were selected as the research objects, 10 ml of fresh mid-stage urine from the patients was collected, and urinary red blood cell morphology examination was performed, combined with the patient′s tongue, pulse, and syndrome characteristics.The patients were classified into syndrome differentiation, and the relationship between urinary red blood cell morphology and TCM syndrome types in patients with purpuric nephritis was explored.Results According to the differentiation of TCM syndromes, 100 patients had apoplexy and heat stroke syndrome in 20 cases (20.0%), heat toxin internal burning syndrome in 12 cases (12.0%), dampness and blood stasis mutual syndrome in 23 cases (23.0%), Qi and Yin deficiency syndrome 36 cases (36.0%), 9 cases (9.0%) of spleen and kidney yang deficiency syndrome; the percentage of abnormal red blood cells and the percentage of spiny red blood cells in patients with deficiency of both qi and yin syndrome were significantly higher than those of other TCM syndrome types, and the differences were statistically significant (P＜0.05).The percentage of abnormal red blood cell content of Qi and Yin deficiency syndrome: target red blood cells＞positive red blood cells＞circular red blood cells＞others＞small red blood cells＞macro red blood cells＞spinous red blood cells, the comparison of red blood cell morphology, and the differences were statistically significant (P＜0.05).The percentage of ring red blood cells in the syndrome of dampness and stasis＞positive erythrocytes＞small red blood cells＞target erythrocytes ＞macro erythrocytes ＞others ＞spinous erythrocytes, and the differences were statistically significant(P＜0.05).The percentage of abnormal erythrocyte content in wind-heat syndrome: small erythrocytes＞erythrocytes＞target erythrocytes＞other ＞ring red blood cells＞macro red blood cells＞acchinoid red blood cells, and the differences were statistically significant (P＜0.05).Percentage of positive red blood cell morphology content in spleen and kidney yang deficiency syndrome＞others＞small red blood cells＞macro red blood cells＞target red blood cells＞ring red blood cells＞spinous red blood cells, and the differences were statistically significant (P＜0.05).The circular red blood cells of the fever syndrome＞positive red blood cells＞others＞target red blood cells＞macro red blood cells＞small red blood cells＞spinous red blood cells, and the differences were statistically significant (P＜0.05).Conclusion TCM syndromes of patients with purpuric nephritis are mostly qi and yin deficiency, and the percentage of abnormal red blood cell content of different TCM syndromes also shows significant differences.The detection of urine red blood cell morphology has important reference significance in TCM syndrome differentiation. 2021 Vol. 28 (29): 153-156 [Abstract] ( 27 ) HTML (36 KB)  PDF  (0 KB)  ( 8 ) 157 Clinical effect of Chinese Tuina massage manipulation on acute lumbar sprain ZHANG Jing-jing Objective To explore the clinical effect of Chinese Tuina massage manipulation on acute lumbar sprain.Methods A total of 60 patients with acute lumbar sprain admitted to the Iron Coal General Hospital of Liaoning Health Industry Group from October 2018 to October 2020 were selected as the research subjects.The patients were divided into an observation group (n=30) and a control group (n=30) by the computer digital random model.The patients in the observation group were treated with Chinese Tuina massage, and patients in the control group were treated with conventional treatment.The clinical treatment effects, the improvement of extremity motor function, quality of life indicators and the alleviation of lumbar pain of the two groups were compared.Results The total effectiveness rate of clinical treatment of patients in the observation group was higher than that of the control group, with statistical significance (P＜0.05).After treatment, the limb function indexes and quality of life scores of the observation group were higher than those in the control group, with statistical significances (P＜0.05).After treatment, the visual analogue scale score of the observation group was lower than that of the control group, with statistical significance (P＜0.05).Conclusion The treatment of Chinese Tuina massage is simple and easy to operate.It has a good therapeutic effect for patients with acute lumbar sprains, can effectively shorten the course of patients and relieve pain symptoms, which is worthy of promotion. 2021 Vol. 28 (29): 157-159 [Abstract] ( 32 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 160 Effect of Buyang Huanwu Decoction combined with acupuncture on stroke patients with hemiplegia and its influence on limb recovery during rehabilitation TAI Jie；LIU Jun-e；ZHENG Ying Objective To analyze the effect of combined treatment of acupuncture and Buyang Huanwu Decoction in stroke patients with hemiplegia.Methods A total of 96 stroke patients with hemiplegia admitted to Liaocheng Second People′s Hospital from January 2020 to December 2020 were selected as the research objects, and they were divided into the control group (48 cases) and the observation group (48 cases) according to the random number table method.The control group was treated with conventional Western medicine, and the observation group was treated with Buyang Huanwu Decoction and acupuncture on this basis.Both groups were treated for four consecutive weeks.The clinical efficacy, limb function, ability of daily living, quality of life, inflammatory index levels (matrix metalloproteinase 9[MMP-9] and high-sensitivity C-reactive protein [hs-CRP]) and adverse reactions were compared between the two groups.Results The total clinical effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).After treatment, the two groups were treated with modified Barthe index (MBI), Fugl-Meyer motor assessment (FMA), stroke special quality of life scale (SS-QOL) score was higher than those before treatment, and the levels of MMP-9 and hs-CRP were lower than those before treatment, the differences were statistically significant (P＜0.05).After treatment, the scores of MBI, FMA, SS-QOL in the observation group were higher than those of the control group, and the levels of MMP-9 and hs-CRP were lower than those of the control group, the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion The combined use of Buyang Huanwu Decoction and acupuncture treatment in patients with stroke and hemiplegia is safe and effective.It can improve the limb function, ability of daily living and quality of life, and reduce inflammation. 2021 Vol. 28 (29): 160-163 [Abstract] ( 38 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 164 Clinical value of detection of T lymphocyte subsets in acute leukemia ZHU Yu Objective To observe the peripheral blood T lymphocyte subsets in patients with acute leukemia (AL), and analyze their clinical application value.Methods From February 2018 to February 2020, 30 patients with AL admitted to Shangrao People′s Hospital were selected as the observation group, and they were divided into acute myeloid leukemia(AML)group and acute lymphoblastic leukemia(ALL)group according to the type of affected cells,with 15 cases in each group.The levels of peripheral blood T lymphocyte subsets were detected by flow cytometry before and after remission induction.Meanwhile, 30 healthy individuals admitted to Shangrao People′s Hospital were selected as the control group.T lymphocyte subsets were comparatively analyzed.The changes in CD3+, CD4+ and CD8+ before and after remission induction were observed, and their clinical application value was analyzed.Results CD3+and CD4+ in the observation group were lower than those in the control group, while CD8+ was higher than those in the control group.CD3+ and CD4+ in the AML group were higher than those in the ALL group, while CD8+ was lower than those in the ALL group, with statistical significances (P＜0.05).After treatment, CD3+ and CD4+ were higher than before treatment,while CD8+was lower than before treatment, the differences were statistically significant (P＜0.05).Conclusion The levels of peripheral blood T lymphocytes decrease significantly in patients with AL, but they recovered after related treatments, indicating that T lymphocyte subsets detection is of certain clinical value in curative effect evaluation and prognosis.This detection method can be used to diagnose blood diseases like hematological malignancies, which is of great significance for preventing onset of the diseases. 2021 Vol. 28 (29): 164-166 [Abstract] ( 43 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 167 Clinical value of C-reactive protein in detection of mycoplasma pneumonia in children HE Jing-dong；CHEN Wei-tu Objective To explore the clinical value of C-reactive protein (CRP) in the detection of mycoplasma pneumonia (MP) in children.Methods A total of 60 cases of MP children in Maoming Maternal and Child Health Care Hospital from March 2019 to March 2021 were selected as the observation group, and a total of 60 cases of healthy children in the same period were selected as the reference group.The serum CRP levels and CRP positive rates of the two groups were compared, the serum CRP levels of the observation group in the acute stage and recovery stage was compared, and the mild and severe cases in the observation group was compared.The levels of serum CRP in the severe group was compared with those in the observation group at admission and 5 days after treatment.Results The level of serum CRP in the observation group was higher than that in the reference group, the positive rate of CRP in the observation group was higher than that in the reference group, and the differences were statistically significant (P＜0.05).The level of serum CRP in acute stage was higher than that in convalescent stage, and the difference was statistically significant (P＜0.05).The level of serum CRP in severe group was higher than that in mild group, the difference was statistically significant (P＜0.05).After 5 days of treatment, the serum CRP level was lower than that on admission, the difference was statistically significant (P＜0.05).Conclusion The level of serum CRP in children with MP is high.With the improvement of the disease, the level of serum CRP will decrease.Strengthening the detection of serum CRP can accurately evaluate the condition of children with MP. 2021 Vol. 28 (29): 167-169转173 [Abstract] ( 35 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 170 Analysis and solutions of 51 cases of discrepancy between positive and negative stereotypes of ABO ZHENG Zhao-li；LIU Jing ；CHENG Xue-mei Objective To analyze the causes of the discrepancy of ABO positive and negative typing, identify the correct blood type, and ensure the safety of patients.Methods From January 2012 to December 2020 in Lianshui People′s Hospital Affiliated to Kangda College of Nanjing Medical University, ABO blood group positive and negative typing specimens were selected for research.The microcolumn gel card manual sampling method was used for ABO positive typing, and the salt tube method was used for the reverse typing.For samples that did not conform to the positive and negative setting, relevant tests were added based on the patient′s clinical data, such as enhanced antigen antibody reaction test, absorption test, diffusion test, and irregular antibody screening test, etc.Results from 2012 to 2020, a total of 51 cases of ABO positive and negative typing specimens were identified in the blood transfusion department of our hospital.The influencing factors were as follows: antigen weakening in 14 cases (27.45%), hematopoietic stem cell transplantation in 1 case (1.96%), cold autoantibody in 16 cases (31.37%), antibody weakening in 11 cases (21.57%), excessive blood group material in 4 cases (7.84%), and multiple myeloma in 5 cases (9.81%).Sixteen cases (31.37%) cold autoantibodies accounted for the largest proportion among them.Conclusion The staff of blood transfusion department should be familiar with the operating procedures of various experiments, matters needing attention and the influence of diseases on blood group identification, and be able to flexibly select and combine various experimental methods to comprehensively judge the blood group results. 2021 Vol. 28 (29): 170-173 [Abstract] ( 50 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 174 Analysis of genitourinary tract pathogen infection of female patients in a hospital WANG Xiang-rong  Objective To analyze the pathogen infection in female reproductive tract samples from outpatients and inpatients in the First Affiliated Hospital of Fujian Medical University.Methods A total of 417 female reproductive tract pathogens nucleic acid samples were collected from outpatients and inpatients of the First Affiliated Hospital of Fujian Medical University from December 2020 to February 2021, and the nucleic acid test results and clinical data of these samples were analyzed.The pathogens include Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT), Mycoplasma genitalium (MG), Mycoplasma hominis (MH), herpes simplex virus typeⅡ(HSV-Ⅱ), Ureaplasma urealyticum (UU) and Ureaplasma parvum (UP), the infection status of the patient were analyzed.Results Among 417 patients, 230 (55.2%)were positive for pathogen nucleic acid.The positive rate of nucleic acid of seven pathogens was statistically significant(P＜0.05), and the positive rate of UP was the highest (38.1%).There was no significant difference in the positive rate of pathogen nucleic acid among female patients of different ages (P＞0.05).The positive rate of pathogen nucleic acid in patients with different clinical symptoms was significantly different (P＜0.05), among which the positive rate of gynecological tumor and urinary and reproductive system infection was higher, 72.4% and 71.3%, respectively.Eighty-two women were infected with two or more pathogens at the same time, with a maximum of six pathogens at the same time.Conclusion With the continuous development of diagnostic technology, molecular diagnosis has been widely used in clinical practice, including DNA detection and RNA detection, which provide a better method for the diagnosis of these pathogens and can provide richer information for clinical diagnosis and treatment.It is necessary to pay attention to the mixed infection of common pathogens in the female reproductive system and strengthen prevention and screening. 2021 Vol. 28 (29): 174-177 [Abstract] ( 30 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 178 Clinical value of D-dimer and coagulation indexes in pregnant women with gestational hypertension WU Li-xia；CHEN Shu-zhu Objective To investigate the clinical value of D-dimer (D-D) and coagulation indexes in pregnant women with hypertension during pregnancy.Methods A total of 68 pregnant women with gestational hypertension admitted to Putian Hanjiang Hospital from January 2018 to December 2020 were selected as the observation group, including 22 cases with simple gestational hypertension, 29 cases with mild preeclampsia (PE), and 17 cases with severe PE.Sixtyeight normal pregnant women were selected as the control group.D-D and coagulation indexes (activated partial thromboplastin time [APTT], prothrombin time [PT], thrombin time [TT]) of pregnant women and pregnant women with different severity of gestational hypertension were compared between the two groups.The correlation between D-D, coagulation indexes and the severity of gestational hypertension was analyzed.Results The D-D level in the observation group was higher than that in the control group, and the APTT, PT and TT were shorter than those in the control group, the differences were statistically significant (P＜0.05).The level of D-D in severe PE group was higher than that in mild PE group and simple gestational hypertension group, the levels of APTT, PT and TT were shorter than those of mild PE group and simple gestational hypertension group, the differences were statistically significant (P＜0.05).The levels of DD in mild PE group were higher than those in simple gestational hypertension group, while the levels of APTT, PT and TT were shorter than those in simple gestational hypertension group, the differences were statistically significant (P＜0.05).D-D was positively correlated with the severity of gestational hypertension, while APTT, PT, TT were negatively correlated with the severity of gestational hypertension (P＜0.05).Conclusion D-D in pregnant women with hypertension during pregnancy is significantly increased, APTT, PT, and TT are significantly reduced.As the severity of the disease increases, D-D tends to increase, and APTT, PT, and TT tend to decrease, which can be used as new ideas for the treatment of hypertension during pregnancy 2021 Vol. 28 (29): 178-180 [Abstract] ( 51 ) HTML (31 KB)  PDF  (0 KB)  ( 5 ) 181 Application value of TCT+HPV+SCC-Ag combined detection in early screening of cervical cancer HUANG Li  Objective To study the application value of thin-cytologic test (TCT)+ human papilloma virus (HPV)+ squamous cell carcinoma antigen (SCC-Ag) combined detection in early screening of cervical cancer.Methods A total of 114 patients from May 2018 to May 2020 in the Fifth People′s Hospital of Jianli City, Hubei Province who tested by TCT, HPV and SCC-Ag were selected as the research objects.They were divided into cervical cancer group (38 cases),cervical benign tumor group (38 cases) and healthy control group (38 cases) according to the pathological results.The TCT, HPV and serum SCC-Ag of the three groups were detected.The receiver operating characteristic (ROC) was used to analyze the clinical value of single and combined detection of TCT, HPV and SCC-Ag in the diagnosis of cervical cancer.Results The positive rates of TCT, HPV and the level of SCC-Ag in serum in cervical cancer group were significant higher than those in benign tumor group and control group, the differences were statistically significant (P＜0.05).ROC showed that the TCT, HPV and SCC-Ag had certain application value in the diagnosis of cervical cancer.The area under the curve, sensitivity and specificity of TCT+HPV+SCC-Ag in the diagnosis of cervical cancer were 0.901, 0.921 and 0.882, respectively.Conclusion TCT+HPV+SCC-Ag combined detection is helpful to improve the diagnostic accuracy of cervical cancer, which can be used for early screening of cervical cancer. 2021 Vol. 28 (29): 181-184 [Abstract] ( 44 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 185 Medical management strategies in the normalized epidemic prevention and control ZHANG Zhi-li； QU Jin-ning；WANG Lu；ZHANG Qiang；ZHANG Yue-ning；HU Zhong-jie Corona virus disease 2019 is a newly highly infectious respiratory disease.Through accurate diagnosis,multiparty efforts, and active treatment, the epidemic has been effectively controlled in China, and main strategy against epidemic has transformed from medical treatment to normal prevention and control.In the face of the outbreak of the epidemic, the hospital has undergone challenges and tests.It is worth thinking about how to do a good job of medical management in the stage of epidemic prevention and control.Based on the practice of epidemic prevention and control and resumption of daily work in Beijing You′an Hospital, Capital Medical University, a series of measures, including of responsibility system of chief attending physician for the establishment of clear rights and responsibilities, multi-disciplinary team for coordinated operation, discipline construction, information enhancement, optimization of the layout and integration of resources , have been carried out to promote medical development. 2021 Vol. 28 (29): 185-188 [Abstract] ( 37 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 189 Management practice of pre-examination and triage at entrance of designated hospitals during the period of epidemic normalization PANG Jie；CHEN Rui-juan； LU Yong-kai；WEN An-xin；GAO Yue；QU Min  Since Wuhan was unsealed on April 8, 2020, by July 22, 2020, 1476 cases of fever have been investigated through pre-examination and triage in the Xi′an Central Hospital.These cases included 788 common cold, fever, 102 oral inflammation, 87 tonsillitis, 335 fever, 66 postoperative fever, 23 fever in middle and high risk areas, 75 fever caused by other non crown fever virus, and 0 novel Coronavirus suspected cases.Xi′an Central Hospital conducts screening and identify cases for patients, companions, medical staff and outsiders in the inpatient department by means of WeChat scanning "one code pass for health" or "one code pass for epidemic prevention travel of the State Council",electronic temperature measuring instrument and mercury thermometer.Method that strict, reasonable and efficient preexamination and triage can effectively avoid cross infection in hospital and improve the efficiency of common patients with fever. 2021 Vol. 28 (29): 189-191转195 [Abstract] ( 42 ) HTML (31 KB)  PDF  (0 KB)  ( 9 ) 192 Effect of self-made medicinal liquor wet compress combined with infrared radiation on pain, lumbar vertebral function and quality of life in patients with spinal diseases HE Ting；XIE Yi-jing；SHU Wen-jie  Objective To explore the effect of self-made medicinal liquor wet compress combined with infrared radiation on pain, lumbar vertebral function and quality of life in patients with spinal diseases.Methods A total of 86 patients with lumbosacral disc herniation (LDH) who were admitted to the Affiliated Hospital of Jiangxi University of Chinese Medicine from August 2019 to December 2020 were selected as the research subjects.According to the random number table method, they were divided into a control group with 43 cases and an observation group with 43 cases.Both groups received conventional treatment.The control group was treated with infrared radiation, and the observation group was treated with self-made medicinal liquor wet compress on the basis of the control group.The clinical efficacy, pain,lumbar vertebral function, and ability of daily living were compared between the two groups.Results The total effectiveness rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).There was no statistically significant difference in the visual analogue scale (VAS)score or the Japanese Orthopedic Association (JOA) score before treatment between the two groups (P＞0.05).After treatment, the VAS scores of the two groups were lower than those before treatment, and the JOA scores were higher than those before treatment, with statistical significances (P＜0.05).After treatment, the VAS score of the observation group was lower than that of the control group, and the JOA score was higher than that of the control group, with statistical significances (P＜0.05).There was no statistically significant difference between the two groups in the ability of daily living (ADL) score before treatment (P＞0.05).The ADL scores of the two groups after treatment were higher than those before treatment,and the differences were statistically significant(P＜0.05).The ADL score of the observation group after treatment was higher than that of the control group, and the difference was statistically significant (P ＜0.05).Conclusion Self-made medicinal liquor wet compress combined with infrared radiation can reduce pain in patients with LDH, facilitate the recovery of lumbar vertebral function, and enhance the ability of daily living. 2021 Vol. 28 (29): 192-195 [Abstract] ( 53 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 196 Effect of alternate nostril breathing in patients with hypertension and anxiety in the community QIU Ting-ting ；LIU Hui-ni ；ZHAO Hong Objective To explore the effect of alternate nostril breathing (ANB) on patients with hypertension comorbid anxiety.Methods A total of 80 patients with hypertension and anxiety established records in community health service centers in Shigu District, Hengyang City, from June to December 2020 were selected, the patients were divided into the intervention group and the control group by random draw method, 40 cases in each group.Two groups of patients were given routine treatment, the control group was given routine management, the intervention group was given ANB nursing.Systolic pressure, diastolic pressure, heart rate, respiratory rate and self-rating anxiety scale (SAS) of the two groups before and after intervention were compared.Results The systolic pressure and diastolic pressure of the intervention group were lower than those of the control group after intervention, the differences were statistically significant(P＜0.05).After intervention, the heart rate and respiratory rate in the intervention group were lower than those in control group, with statistical differences (P＜0.05).The score of the SAS of the intervention group was lower than that of the control group after intervention, the difference was statistically significant (P＜0.05).Conclusion ANB decreases the level of systolic pressure, diastolic pressure, heart rate, respiratory rate of patients with hypertension comorbid anxiety in the community, and improves the anxiety level in hypertensives. 2021 Vol. 28 (29): 196-199 [Abstract] ( 41 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 200 Influence of holistic nursing intervention on mental state and quality of life of patients in department of infectious diseases WU Li-dan Objective To study and analyze the improvement effect of holistic nursing intervention on patients′ mental state and quality of life in the treatment of patients in the department of infectious diseases.Methods A total of 120 patients who were admitted to Fuzhou First People′s Hospital from June 2018 to June 2020 were selected.All patients were divided into the study group and the control group according to the order of admission, 60 cases in each group.The control group was treated with conventional nursing, and the study group was treated with holistic nursing intervention.The mental state improvement, quality of life improvement and nursing satisfaction were compared between the two groups.Results In the study group, the self-rating anxiety scale (SAS) and self-rating depression scale (SDS)scores after nursing were lower than those before nursing, and the quality of life score (QOL) after nursing was higher than that before nursing, with statistical differences (P＜0.05).In the control group, the SAS and SDS scores after nursing were lower than those before nursing, and the QOL score after nursing was higher than that before nursing, with statistical differences (P＜0.05).No significant differences were observed in the SAS score, SDS score and QOL score between the two groups before nursing (P＞0.05).After nursing, the SAS score and SDS score of the study group were lower than those of the control group, and the QOL score of the study group was higher than that of the control group,with statistical differences (P＜0.05).The total satisfaction of nursing in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion Holistic nursing intervention can effectively improve the mental state and quality of life of patients, and improve nursing satisfaction, with the significant effect. 2021 Vol. 28 (29): 200-202转206 [Abstract] ( 43 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 203 Influence of nursing intervention model based on Orem self-care theory on self-care ability and social function in patients with schizophrenia ZHANG Jing  Objective To explore the application value of nursing intervention model based on Orem self-care theory in patients with schizophrenia.Methods A total of 72 patients with schizophrenia admitted to Jiujiang Fifth People′s Hospital from November 2019 to November 2020 were selected as the research subjects.The patients were divided into the control group (n=36) and the observation group (n=36) by random number table method.The patients in the control group carried out routine nursing care, and the patients in the observation group adopted a nursing intervention model based on Orem′s self-care theory.The self-care ability, social function, self-esteem and overall well-being were compared between the two groups.Results Before the intervention, there were no statistically significant differences in the scores of self-concept, health awareness, self-responsibility, and self-care skills between the two groups (P＞0.05).After the intervention, self-concept, health awareness, and self-responsibility and the scores of self-care skills of the observation group were (26.64±3.58), (54.74±6.18), (19.75±3.56) and (39.61±4.72) points, higher than those of the control group of (22.58±3.27), (46.83±5.12), (15.24±3.21) and (34.46±4.05) points, with statistical differences (P＜0.05).Before the intervention, the social disability screening schedule (SDSS) and self-esteem scale (SESS) and the general well-being schedule (GWB) of the two groups did not show statistical significances (P＞0.05).After the intervention, the SESS and GWB scores of the observation group were (33.69±4.80) and (84.37±9.71) points, respectively, higher than those of the control group of (26.84±4.01) and (74.28±8.69) points, and the SDSS score of the observation group was (5.27±1.58)points, lower than the control group of (8.36±1.92) points, with statistical differences (P＜0.05).Conclusion The nursing intervention model based on Orem self-care theory can improve the self-care ability in patients with schizophrenia, improve their social functions, and enhance their sense of self-esteem and well-being.It is worthy of clinical application. 2021 Vol. 28 (29): 203-206 [Abstract] ( 57 ) HTML (33 KB)  PDF  (0 KB)  ( 4 ) 207 Application effect of comfortable nursing in patients with indwelling gastric tube after endoscopic submucosal dissection ZHU Yong-mei；LAI Li-xia Objective To explore the application effect of comfortable nursing in patients with indwelling gastric tube after endoscopic submucosal dissection (ESD).Methods A total of 103 cases of patients with indwelling gastric tube after ESD in Pingxiang People′s Hospital from January 2017 to March 2021 were selected as the research objects, and they were divided into the control group (n=51) and the observation group (n=52) by random drawing method.The control group was given routine nursing after indwelling gastric tube, and the observation group was given comfortable nursing on the basis of the control group.The comfort degree, negative emotion and nursing satisfaction of the two groups were compared.Results The comfort degree of the observation group was better than that of the control group,the difference was statistically significant (P＜0.05）.The proportion of comfort of the observation group was 90.38%,which was higher than 56.86% of the control group, with statistical difference (P＜0.05）.Before nursing, there were no statistical differences in the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores between the two groups (P＞0.05）.After nursing, the SAS and SDS scores of the two groups were lower than those before nursing,and the SAS and SDS scores of the observation group were lower than those of the control group, with statistical differences (P＜0.05）.The total nursing satisfaction of the observation group was 96.15%, which was higher than 80.39% of the control group, with statistical difference (P＜0.05）.Conclusion Comfort nursing is effective in the patients with gastric tube after ESD operation, which can improve the comfort of patients, improve the negative emotions of patients, improve the satisfaction of nursing, and it is worthy of clinical promotion and application. 2021 Vol. 28 (29): 207-210 [Abstract] ( 47 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 211 Study on the prognosis of elderly patients with chronic obstructive pulmonary disease in multidisciplinary collaborative nursing led by specialist nurses HUANG Hui LI Mei WU Na  Objective To explore the impact of multidisciplinary collaborative nursing led by specialist nurses on the prognosis of elderly patients with chronic obstructive pulmonary disease (COPD).Methods A total of 160 elderly COPD patients admitted to the Yuebei People′s Hospital, Shaoguan from January to June 2020 were selected as the research objects, and were divided into the control group (80 cases) and the test group (80 cases) according to random number table method.The control group was provided with routine nursing care, and the observation group was provided with multidisciplinary collaborative nursing led by specialist nurses.The lung function indexes, quality of life, dyspnea score, 6-min walking distance before and 6 months after the intervention were compared between the two groups, and the number of acute exacerbations within 6 months and patient satisfaction were counted.Results Before the intervention, there were no statistically significant differences between the two groups of lung function indexes, St.George′s finger respiratory questionnaire (SGRQ), dyspnea scale (mMRC) scores and 6-min walk test (6MWT) distance (P＞0.05).After the intervention, the forced vital capacity (FVC), the percentage of forced expiratory volume in the first second to the predicted value (FEV1%) and the maximum expiratory flow rate (PEF) of the test group were higher than those of the control group, and the differences were statistically significant (P＜0.05).The SGRQ and mMRC scores of the test group were lower than those of the control group, and the 6MWT distance was greater than that of the control group, the differences were statistically significant (P＜0.05).The number of acute attacks within 6 months of the test group was less than that of the control group, and the satisfaction score was higher than that of the control group, the differences were statistically significant (P＜0.05).Conclusion The multidisciplinary collaborative nursing led by specialist nurses can significantly improve the lung function, respiratory status, exercise endurance and quality of life of elderly COPD patients, reduce the number of COPD attacks, and improve patient satisfaction. 2021 Vol. 28 (29): 211-214 [Abstract] ( 45 ) HTML (36 KB)  PDF  (0 KB)  ( 5 ) 215 Application of universal regulating stent in patients with cerebral hemorrhage after ventricular drainage LI Xiao-lan Objective To investigate the effect of universal regulating stent in patients with cerebral hemorrhage after ventricular drainage.Methods 108 cases of cerebral hemorrhage patients who were received ventricular drainage in Intervention Department of General Hospital of Pingxiang Mining Group Co., Ltd.from April 2019 to January 2021 were retrospectively analysised.They were randomly divided into observation group and control group, with 54 cases in each group.In the observation group, the drainage bag was fixed with a universal regulating stent, and the adjustment accuracy, time saving, release rate and total postoperative rebleeding rate were observed.Results The drainage volume,catheterization time, adjustment accuracy and visual analogue scale (VAS) score in the observation group were lower than those in the control group (P＜0.05); the levels of intracranial pressure in the observation group were lower than those in the control group at 12, 24 and 72 h after surgery (P＜0.05); compared with 12 h and 24 h after operation, the intracranial pressure of the two groups decreased at 72 h (P＜0.05); the total incidence of adverse reactions in the observation group was lower than that in the control group (P＜0.05).Conclusion The niversal regulating stent to fix the ventricular drainage tube is beneficial to shorten the time of catheter placement, relieve pain, reduce intracranial pressure, improve the safety of catheter placement, and can be popularized in clinical application. 2021 Vol. 28 (29): 215-217 [Abstract] ( 42 ) HTML (29 KB)  PDF  (0 KB)  ( 6 ) 218 Effect of school education for pregnant women on postpartum breastfeeding GONG Lve；LI Xiao-pan；GUO Yu-mei ；WEI Liang-yan Objective To explore the influence of school education for pregnant women on postpartum breastfeeding.Methods A total of 100 parturients who were admitted to Central People′s Hospital of Ji′an City and underwent the pregnancy test from May 2019 to January 2020 were selected as the research objects.According to the random number table method, they were divided into control group and experimental group, with 50 cases in each group.The control group was treated with the conventional education method, and the experimental group was treated with the school education method for pregnant women on the basis of the control group.The awareness rates of breastfeeding knowledge, postpartum breastfeeding rates, incidences of neonatal diseases and incidences of postpartum breast diseases were compared between the two groups.After discharged from hospital, the parturients in both groups were followed up for 6 months through door-to-door, telephone and WeChat.Results After intervention, the awareness rate of the parturients in the experimental group (96.00%) was higher than that in the control group (82.00%), and the difference was statistically significant (P＜0.05).The breastfeeding rate of the pregnant women in the experimental group was higher than that in the control group, while the incidence rates of neonatal diseases and postpartum breast diseases were lower than those in the control group, with statistically significant differences (P＜0.05).Conclusion By teaching parturients knowledge and skills on breastfeeding, school education for pregnant women can increase the breastfeeding rate and awareness rate of breastfeeding knowledge, reduce the incidence of neonatal diseases and postpartum breast diseases,and promote the health of mothers and infants. 2021 Vol. 28 (29): 218-220转224 [Abstract] ( 43 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 221 Application of synchronous cognitive intervention for family members in patients with small pulmonary nodules LI Yan-ling；ZHANG Ji-mei； YIN Chun-yan； LI Hui-ming Objective To explore the value and advantages of synchronous cognitive intervention for family members in patients with small pulmonary nodules.Methods A total of 115 patients with small pulmonary nodules admitted to Chenggong District People′s Hospital, Kunming from April 2019 to November 2020 were selected.They were divided into the comparison group (57 cases) and the analysis group (58 cases) using simple random method.The comparison group were given conventional nursing method and the analysis group were given synchronous cognitive method for family members.The psychological status, scores of health knowledge mastery and health behavior, quality of daily life score and nursing satisfaction were compared between the two groups.Results The scores of anxiety scale and depression scale in the analysis group were lower than those in the comparison group, with statistical differences (P＜0.05).The scores of health knowledge mastery and health behavior in the analysis group were higher than those in the comparison group, with statistical differences (P＜0.05).The scores of social function, energy, physical pain, and physiological function in the analysis group were higher than those in the comparison group, with statistical differences (P＜0.05).The nursing total satisfaction in the analysis group was 98.28%, which was higher than that in the comparison group of 82.46%, with statistical difference (P＜0.05).Conclusion Synchronous cognitive intervention for family members can improve psychological state, daily life，health knowledge mastery and health behavior, and build a good nurse-patient relationship in patients with small pulmonary nodules.It is worthy of popularization and application. 2021 Vol. 28 (29): 221-224 [Abstract] ( 45 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 225 Effect of midwife integrated nursing service model on delivery outcome of second pregnancy in women with scarred uterus YU Dan；LIU Rong-jun；FU Yan-hui Objective To study and analyze the effect of midwife integrated nursing service model (continuous service model) on the natural delivery and delivery outcome of second pregnancy in women with scarred uterus.Methods A total of 120 women with scarred uterus in second pregnancy who were treated in Shaoguan Occupational Disease Prevention and Control Hospital from January 2020 to January 2021 were selected.They were divided into the control group and the experimental group using random number table method, 60 cases in each group.The control group was given conventional nursing model for pregnant women, and the experimental group was given midwife integrated nursing service model.The delivery method，delivery process, postpartum hemorrhage of pregnant women, Apgar score of newborns, unhealthy emotions of pregnant women, adaptability of pregnant women to the mother′s role, and degree of satisfaction of pregnant women with different nursing models were compared between the two groups.Results The vaginal delivery rate in the experimental group was 65.00%, which was higher than that in the control group as 43.33%, with statistical difference (P＜0.05).The cesarean section rate in the experimental group was 18.33%, which was lower than that in the control group of 41.67%, with statistical difference (P＜0.05).The lengths of first stage of labor, second stage of labor and total labor in the experimental group were shorter than those in the control group, with statistical differences (P＜0.05).The bleeding rate in the experimental group was lower than that in the control group, and the blood losses at 2 and 24 h postpartum in the experimental group were less than those in the control group, with statistical differences (P＜0.05).The Apgar scores of newborns in the experimental group at 1 and 5 minutes were higher than those in the control group, with statistical differences (P＜0.05).The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores in the two groups before nursing were no statistical significant (P＞0.05).The SAS and SDS scores in the experimental group after nursing were lower than those in the control group, with statistical differences (P＜0.05).The adaptability in the experimental group was higher than that in the control group, with statistical difference (P＜0.05).The total satisfaction in the experimental group was 98.33%, which was higher than that in the control group of 80.00%,with statistical difference (P＜0.0.05).Conclusion Midwives provide continuous services to pregnant women with scarred uterus in second pregnancy, which can help pregnant women have smooth delivery and greatly improve the outcome of mothers and newborns, with good nursing satisfaction.It is worthy of clinical promotion. 2021 Vol. 28 (29): 225-228 [Abstract] ( 40 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 229 Application of humanized communication combined with self-identified psychological nursing in the prevention of self-harm/suicide behaviors in male psychosis patients XU Cai-xia  Objective To explore the application effect of humanized communication combined with self-identified psychological nursing in the prevention of self-harm/suicide behaviors in male psychosis patients.Methods A total of 84 inpatient male psychosis patients confirmed in Shangrao Third People′s Hospital in Jiangxi Province from January 2019 to August 2020 were selected and divided into the control group and the observation group by random number table method, 42 cases in each group.The control group was given self-identified psychological nursing, while the observation group was given humanized communication combined with self-identified psychological nursing.Both groups were intervened for 30 d.The differences in the incidence of adverse events (self-harm, suicide) and scores of quality of life (physiological function, physical pain, social function, mental health) before and after intervention were compared between the two groups.Results After intervention, the incidence of self-harm and suicide in both groups were lower than those before intervention, the incidence of self-harm and suicide in the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05).After intervention, scores of physiological function, physical pain, social function and mental health in both groups were lower than those before intervention,scores of physiological function, physical pain, social function and mental health in the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05).Conclusion The application of humanized communication combined with self-identified psychological nursing can reduce the incidence of selfharm/suicide and other harmful behaviors in male psychosis patients, and improve the overall quality of life. 2021 Vol. 28 (29): 229-231 [Abstract] ( 43 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 232 Application effect of optimizing emergency nursing in the rescue of patients with acute myocardial infarction LAN Li；HU Mei-ling； SHENG Nan；AN Xuan-yu Objective To explore the application effect of optimizing emergency nursing on the rescue of patients with acute myocardial infarction (AMI) and the influence of emergency success rate.Methods A total of 70 patients with AMI admitted to Hongqi Hospital Affiliated to Mudanjiang Medical University from January 2018 to January 2020 were selected as the research objects, and they were divided into the observation group and the control group by computer two color ball grouping method, 35 cases in each group.The observation group was given optimized emergency nursing,while the control group was given routine nursing.The rescue time, disability rate, mortality rate, neurological function and activities of daily living were compared between the two groups.Results The time from calling for help to rescue and from calling for help to formal treatment in the observation group was shorter than that in the control group, the differences were statistically significant (P＜0.05).The disability rate in the observation group was lower than that in the control group, the mortality rate in the observation group was lower than that in the control group, the differences were statistically significant (P＜0.05).There were no significant differences between BI index and national institutes of health stroke scale (NIHSS) score in the two groups before nursing (P＞0.05); after nursing, BI index of the observation group was higher than that of the control group, NIHSS score was lower than that of the control group, the differences were statistically significant (P＜0.05).Conclusion The application effect of optimizing emergency nursing in the rescue of patients with AMI is significant, the success rate of first aid is high, and the scheme is worthy of promotion. 2021 Vol. 28 (29): 232-234 [Abstract] ( 38 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 235 Effect of continuous stage-based nursing on postoperative pain degree and lactation function in pregnant women with cesarean section ZHU Hong Objective To investigate the effect of continuous stage-based nursing on postoperative pain degree and lactation function in pregnant women with cesarean section.Methods A total of 65 pregnant women with cesarean section who were treated in Shangrao Traditional Chinese Medicine Hospital, Jiangxi Province from January 2016 to January 2019 were selected and divided into the control group (n=33) and the observation group (n=32) by random number table method.The control group was given routine nursing, and the observation group was given continuous stage-based nursing based on control group.The score of numerical rating scale (NRS), postpartum lactation function and postoperative recovery of pregnant women were compared between the two groups.Results The NRS scores of the two groups′women after intervention were lower than those before intervention, and the NRS scores of the observation group after intervention were lower than those of the control group, the differences were statistically significant (P＜0.05).The lactation initiation time of the observation group was shorter than that of the control group, and the lactation output at 24 h postpartum was more than that of the control group, the differences were statistically significant (P＜0.05).The first anal exhaust time, the first defecation time, the time to get out of bed and the incision healing time of the observation group were shorter than those of the control group, and the differences were statistically significant (P＜0.05).Conclusion Continuous stage-based nursing can alleviate postoperative pain degree of pregnant women, shorten the starting time of lactation, increase postpartum 24 h milk yield, improve lactation function, and promote postoperative recovery. 2021 Vol. 28 (29): 235-237 [Abstract] ( 43 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 238 Application of collaborative nursing model in patients with dementia ZHAO Zi-yu；AI Chen-lu；ZHAO Jing-hua；GAO Ying-zhe；LI Jie Objective To explore the application effect of collaborative nursing model in patients with dementia.Methods A total of 200 patients with dementia from April 2020 to March 2021 treated in Shenyang Watson Jingan Mental Health Hospital and Shenyang Anning Hospital were selected as the research subjects.According to the random number table method, they were divided into the control group and the observation group, 100 cases in each group.Patients in the control group adopted conventional nursing intervention measures, and patients in the observation group adopted collaborative nursing model, to observe the personality changes, hallucinations, delusions, depression, behavior problems, and identification errors of the two groups before and after the intervention.The incidence of adverse events,compliance, and satisfaction of patients′ family members were observed.Results Before the intervention, there were no significant differences in the incidence rates of personality changes, hallucinations, delusions, depression, behavior problems, or identification errors between the two groups of patients (P＞0.05).After the intervention, the incidence rates of personality changes, hallucinations, delusions, depression, behavior problems and identification errors in the two groups were lower than those before the intervention, the incidence rates of personality changes, hallucinations, delusions, depression, behavior problems and identification errors in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).The incidence of adverse events in the observation group was lower than that in the control group, compliance and satisfaction of patients′ family members were higher than those in the control group, the differences were statistically significant (P＜0.05).Conclusion The application of the collaborative care model to patients with dementia can improve the behavioral and psychiatric symptoms of patients,reduce the incidence of adverse events, and improve compliance and satisfaction. 2021 Vol. 28 (29): 238-240 [Abstract] ( 47 ) HTML (32 KB)  PDF  (0 KB)  ( 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