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| Clinical value of D-dimer and coagulation indexes in pregnant women with gestational hypertension |
| WU Li-xia CHEN Shu-zhu▲ |
| Department of Laboratory Medicine, Putian Hanjiang Hospital |
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Abstract Objective To investigate the clinical value of D-dimer (D-D) and coagulation indexes in pregnant women with hypertension during pregnancy.Methods A total of 68 pregnant women with gestational hypertension admitted to Putian Hanjiang Hospital from January 2018 to December 2020 were selected as the observation group, including 22 cases with simple gestational hypertension, 29 cases with mild preeclampsia (PE), and 17 cases with severe PE.Sixtyeight normal pregnant women were selected as the control group.D-D and coagulation indexes (activated partial thromboplastin time [APTT], prothrombin time [PT], thrombin time [TT]) of pregnant women and pregnant women with different severity of gestational hypertension were compared between the two groups.The correlation between D-D, coagulation indexes and the severity of gestational hypertension was analyzed.Results The D-D level in the observation group was higher than that in the control group, and the APTT, PT and TT were shorter than those in the control group, the differences were statistically significant (P＜0.05).The level of D-D in severe PE group was higher than that in mild PE group and simple gestational hypertension group, the levels of APTT, PT and TT were shorter than those of mild PE group and simple gestational hypertension group, the differences were statistically significant (P＜0.05).The levels of DD in mild PE group were higher than those in simple gestational hypertension group, while the levels of APTT, PT and TT were shorter than those in simple gestational hypertension group, the differences were statistically significant (P＜0.05).D-D was positively correlated with the severity of gestational hypertension, while APTT, PT, TT were negatively correlated with the severity of gestational hypertension (P＜0.05).Conclusion D-D in pregnant women with hypertension during pregnancy is significantly increased, APTT, PT, and TT are significantly reduced.As the severity of the disease increases, D-D tends to increase, and APTT, PT, and TT tend to decrease, which can be used as new ideas for the treatment of hypertension during pregnancy
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