不同维持剂量枸橼酸咖啡因对极早产儿呼吸暂停治疗效果和早期脑电活动的影响

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Abstract Objective To investigate the effect of different maintenance doses of Caffeine Citrate on the treatment of apnea and the early-stage brain electrical activities among very preterm infants with primary apnea.Methods A total of 56 cases of very preterm infants with primary apnea and administered by Fujian Provincial Hospital from January 2018 to December 2019 were selected as the research objects and divided into the observation group and the control group by random number table method, with 28 cases in each group.The two groups both received the conventional treatment combined with the caffeine citrate treatment.The maintenance dose of Caffeine Citrate was 10 mg/(kg·d) for the observation group and 5 mg/(kg·d) for the control group.Both groups were suspended from taking the drug after symptoms of apnea disappeared for seven days.The treatment effect, adverse reactions and complications, and amplitude integrated electroencephalogram (aEEG) maturity score were compared between the two groups.Results After 48 h of treatment,the number of apnea attacks in the observation group was less than that in the control group, the duration of mechanical ventilation, oxygen inhalation and caffeine treatment were shorter than those in the control group, and the aEEG maturity score adjusted for gestational age of 34, 36 and 40 weeks were higher than those in the control group, and the differences were statistically significant (P＜0.05).There were no statistically significant differences in the total incidence of adverse reactions and complications between the two groups (P＞0.05).Conclusion When the maintenance dose of caffeine citrate was 10 mg/(kg·d), the primary apnea symptoms of very preterm infants could be better alleviated, the maturity of brain electrical activities could be promoted, and the occurrence rate of adverse reactions and complications demonstrated no obvious increase.

Key words： Apnea of prematurity Very pretern infant Caffeine citrate Amplitude integrated electroencephalography

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	YANG Mei-Jun

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YANG Mei-Jun. Effect of different maintenance doses of Caffeine Citrate on the treatment of apnea and the early -stage brain electrical activities among very preterm infants with primary apnea[J]. 中国当代医药, 2021, 28(29): 132-135.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I29/132

[1]	陈静，陈晓，龚放.不同维持剂量枸橼酸咖啡因治疗早产儿呼吸暂停疗效和安全性的meta 分析[J].临床儿科杂志，2018，36（9）：55-59.
[2]	王家玉，肖磊，胡亚澜，等.高剂量与常规剂量咖啡因治疗早产儿呼吸暂停症的系统评价[J].药物流行病学杂志，2019，28（11）：728-732.
[3]	Padden B，Scheer I，Brotschi B，et al.Does amplitude-integrated electroencephalogram background pattern correlate with cerebral injury in neonates with hypoxic-ischaemic encephalopathy?[J].J Paediatr Child Health，2015，51（2）：180-185.
[4]	邵肖梅，叶鸿瑁，丘小汕．实用新生儿学[M].5 版.北京：人民卫生出版社，2018：610-612.
[5]	施亿赟，程国强，邵肖梅，等.正常早产儿振幅整合脑电图特点的研究[J].中华儿科杂志，2011，49（9）：648-654.
[6]	Anyanwu AC，Bentley JK，Popova AP，et al.Suppression of inflammatory cell trafficking and alveolar simplification by the heme oxygenase-1 product carbon monoxide[J].Am J Physiol Lung Cell Mol Physiol，2014，306（8）：L749-L763.
[7]	杨洋，程锐，吴琦，等.不同起始时间应用咖啡因对早产儿安全性及有效性的评估：一项江苏省多中心研究[J].中国当代儿科杂志，2020，22（2）：49-54.
[8]	林建丰，庄泽吟，陈淑特.枸橼酸咖啡因在早产儿呼吸机辅助通气中的临床效果[J].中国当代医药，2019，26（35）：159-162.
[9]	秦素芳.枸橼酸咖啡因在早产儿原发性呼吸暂停中的研究进展[J].中国当代医药，2018，25（36）：25-27.
[10]	Alhersh E，Abushanab D，Al-Shaibi S，et al.Caffeine for the Treatment of Apnea in the Neonatal Intensive Care Unit：A Systematic Overview of Meta-Analyses[J].Pediatr Drugs，2020，22（4）：399-408.
[11]	杨瑞芬.枸橼酸咖啡因治疗早产儿呼吸暂停的效果[J].实用临床医学，2020，21（8）：54-55.
[12]	孟伟玲，刘庆生，刘玉荣，等.枸橼酸咖啡因改善早产儿辅助通气及呼吸暂停的临床效果及安全性分析[J].临床肺科杂志，2020，25（2）：281-283，287.
[13]	Sanchez-Solis M，Garcia-Marcos PW，Agüera-Arenas J，et al.Impact of early caffeine therapy in preterm newborns on infant lung function[J].Pediatr Pulmonol，2020，55（1）：102-107.
[14]	Ulanovsky I，Haleluya NS，Blazer S，et al.The effects of caffeine on heart rate variability in newborns with apnea of prematurity[J].J Perinatol，2014，34（8）：620-623.
[15]	Frymoyer A，Su F，Grimm PC，et al.Theophylline Population Pharmacokinetics and Dosing in Children Following Congenital Heart Surgery With Cardiopulmonary Bypass[J].J Clin Pharmacol，2016，56（9）：1084-1093.
[16]	Muhammad M，El-Ta′alu AB，Mohammed MA，et al.Effect of caffeine on serum tumour necrosis factor alpha and lactate dehydrogenase in Wistar rats exposed to cerebral ischaemia-reperfusion injury[J].Niger J Physiol Sci，2018，33（1）：3-8.
[17]	Lodha A，Entz R，Synnes A，et al.Early Caffeine Administration and Neurodevelopmental Outcomes in Preterm Infants[J].Pediatrics，2019，143（1）：889-899.
[18]	Ravichandran S，Chouthai NS，Patel B，et al.Higher daily doses of caffeine lowered the incidence of moderate to severe neurodevelopmental disabilities in very low birth weight infants[J].Acta Paediatr，2019，108（3）：430-435.
[19]	Czaba-Hnizdo C，Olischar M，Rona Z，et al.Amplitude-integrated electroencephalography shows that doxapram influences the brain activity of preterm infants[J].Acta Paediatr，2015，103（9）：922-927.
[20]	Burdjalov VF，Baumgart S，Spitzer AR.Cerebral function monitoring：a new scoring system for the evaluation of brain maturation in neonates[J].Pediatrics，2003，112（4）：855-861.