基于网络药理学和生物信息学的结肠炎奇效颗粒治疗溃疡性结肠炎作用机制研究

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Abstract Objective To investigate the mechanism and explore the active compounds, key targets and signal pathways of Jiechangyan Qixiao Granules in the treatment of ulcerative colitis, it was analyzed by network pharmacology and bioinformatics.Methods Firstly, based on the total chemical composition of Jiechangyan Qixiao Granules, pharmacology analysis platform of traditional Chinese medicine system (TCMSP), chemistry database and Swiss ADME were combined to search and screen the potential targets related to compounds.Meanwhile, the targets related to ulcerative colitis were acquired through DiGSeE and Gene Cards, and the drug-disease targets were obtained by intersecting the results of these two databases.The drug-disease-target network was constructed through visualization analysis of STRING and Cytoscape software.Moreover, core targets were screened based on the algorithm of network topology.Then, GO function and KEGG metabolic pathway enrichment analysis of these core targets were performed by DAVID 6.8 database.Finally, the mechanism of Jiechangyan Qixiao Granules in treating ulcerative colitis was analyzed with relevant literatures.Results There were 12 potential active compounds and 269 potential interactive targets in Jiechangyan Qixiao Granules, with 32 core targets were selected from 64 drug-disease targets.A total of 32 enrichment results were obtained by GO analysis, mainly involving inflammatory response, positive regulation of nitric oxide biosynthetic process, etc.Simultaneously, 32 metabolic pathways were obtained by KEGG, primarily including pathways in cancer, tumor necrosis factor signaling pathway, etc. Conclusion The characteristic of Jiechangyan Qixiao Granules with multi-compounds, multi-targets, multi-components and multi-pathways in the treatment of ulcerative colitis is revealed by network pharmacology.The potential active compounds, key targets and mechanism are predicted as well.Moreover, there is a high degree of coincidence between prediction and pharmacological experiments, which can verify each other.These results provide clues and references for the subsequent screening of effective parts and the study of pharmacodynamic material basis.

Key words： Ulcerative colitis Jiechangyan Qixiao Granules Network pharmacology Targets Mechanism

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	Articles by authors
	SUN Yu-jing
	HUO Zhi-peng
	WANG Yu
	LI Rui-ming
	QIN Min-jian
	HE Yi

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SUN Yu-jing,HUO Zhi-peng,WANG Yu, et al. Mechanism of Jiechangyan Qixiao Granules in the treatment of ulcerative colitis based on network pharmacology and bioinformatics[J]. 中国当代医药, 2021, 28(29): 4-8.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I29/4

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