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Quick Search     Adv Search 2018 Vol. 25, No. 13 Published: 2018-05-08   4 Comparison of the characteristics of the conventional ultrasound and contrast-enhanced ultrasound in papillary thyroid carcinoma of different sizes FAN Wen-wen； LIU Li-ping； ZHANG Yan-jing； WANG Xiao-jing ；LIU Jing-jing Objective To investigate the characteristics of the conventional ultrasound and contrast-enhanced ultrasound(CEUS)in papillary thyroid carcinoma of different sizes.Methods The ultrasonographic features of 197 cases(239 nodules)of papillary thyroid carcinoma which were confirmed by surgical pathology in our hospital from January 2016 to September 2017 were analyzed retrospectively.These papillary thyroid carcinomas were divided into papillary thyroid micro-carcinoma (PTMC)and papillary thyroid carcinoma (non-PTMC)which size greater than 1 cm according to the nodule′s size,and the conventional ultrasound and the CEUS characteristics of them were comparatively studied.Results There were 128 cases of PTMC and 111 cases of non-PTMC.The A/T＞1 in PTMC group was more obvious than that in non-PTMC group (64.8%vs.15.3%),the micro-calcification in PTMC were less than that in non-PTMC(61.7%vs.82.9%),which showed significant difference between the two groups (all P＜0.05).Compared with non-PTMC,heterogeneous enhancement and centripetal enhancement of PTMC was less(59.4%vs.79.3%,37.5%vs.51.4%),and significant difference were founded(all P＜0.05).No significant difference were founded in echo,margin and the enhancement intensity between two groups (all P＞0.05).Conclusion In different sizes′papillary thyroid carcinoma,the ultrasonographic characteristics are different.The A/T＞1 is much more common in micro-carcinoma,which is helpful for detecting PTMC.With the size greater,the incidence of micro-calcification,heterogeneous enhancement and centripetal enhancement is much more. 2018 Vol. 25 (13): 4-7 [Abstract] ( 170 ) HTML (40 KB)  PDF  (0 KB)  ( 27 ) 8 Clinical effect of thoracoscopic subxiphoid small incision in the treatment of bilateral thymomas CHENG Shao-xian；XU Wen-li；AI Rui-hua；ZHANG Yao-qing；LIAO Yong-de Objective To compare the clinical effects of routine thoracotomy,VATS intercostal surgery and VATS subxiphoid small incision in the treatment of early thymomas,and to investigate the feasibility and superiority of VATS subxiphoid small incision surgery for bilateral thymomas.Methods A total of 62 patients with thymoma who met the diagnosis criteria of phaseⅠ-Ⅱ of the Masaoka staging method in our hospital from January 2014 to June 2017 were selected as the study subjects.They were assigned to different groups based on different surgical methods.A total of 16 patients were given VATS subxiphoid small incision surgery,24 patients were given VATS intercostal surgery,and 22 patients were given a traditional frontal and midline incision sternotomy.The surgery time,intraoperative blood loss,drainage time,length of stay,pain degree,antibacterial time,complication rate,and patient satisfaction were compared between the three groups.Results The operative time,postoperative drainage time,antibacterial time and postoperative hospitalization days in VATS subxiphoid group were shorter than those in VATS intercostal group and sternotomy group,the intraoperative blood loss in VATS subxiphoid group was less than that in VATS intercostal group and sternotomy group,with significant difference(P＜0.05).The incidence rate of complications in the three groups was 6.25%,12.50%,18.18%,and satisfaction was 81%,59%,42%,and the differences were statistically significant(P＜0.05).The advantage of VATS subxiphoid group was significant.During the follow-up period,no recurrence or metastasis was observed in all the three groups.Conclusion The VATS subxiphoid small incision in the treatment of bilateral thymoma reduces the surgical trauma,reduces the incidence rate of complications,alleviates the patient′s pain and shortens the hospital stay.It is worthy of clinical promotion and application. 2018 Vol. 25 (13): 8-12 [Abstract] ( 158 ) HTML (51 KB)  PDF  (0 KB)  ( 31 ) 13 Influence of Salmeterol and Fluticasone Propionate on eosinophil and immunoglobulin E and pulmonary function outcome in children patients with asthma CHEN Guo-hua； PAN Zhi-wei；BAI Jun ；CHEN Liang Objective To explore the influence of Salmeterol and Fluticasone Propionate (Seretide)on peripheral blood eosinophils(EOS),immunoglobulin E(IgE)and pulmonary function outcome in asthmatic children patients.Methods A total of 62 children patients with asthma in our hospital from March 2015 to September 2017 were selected for the study and were divided into the control group (n=31)and the observation group (n=31).The control group was given Fluticasone Propionate aerosol inhalation,and the observation group was given Salmeterol and Fluticason aerosol inhalation.The clinical efficacy was recorded in the two groups,and the levels of peripheral blood EOS and IgE,and pulmonary function(forced vital capacity[FVC],forced expiratory volume in 1 second[FEV1],peak expiratory flow rate[PEF])were compared between the two groups before treatment and after 4 weeks of treatment.Results The efficacy in the observation group was better than that in the control group,with significant difference(P＜0.05).After 4 weeks of treatment,the levels of peripheral blood EOS and IgE in the observation group were lower than those in the control group,with significant difference (P＜0.05),while the levels of FVC,PEF and EFV1were higher than those in the control group,with significant difference (P＜0.05).After treatment,the levels of EOS and IgE in peripheral blood were lower than those before treatment(P＜0.05),while the levels of FVC,PEF and FEV1were higher than those before treatment(P＜0.05).Conclusion Salmeterol and Fluticasone Propionate can not only reduce the inflammatory response of asthmatic children patients and improve the immune function,but also enhance pulmonary function,and it is favorable for disease outcome. 2018 Vol. 25 (13): 13-15转19 [Abstract] ( 166 ) HTML (36 KB)  PDF  (0 KB)  ( 34 ) 16 The effect of Spironolactone combined with Amlodipine Mesylate Tablets in the treatment of elderly hypertensive heart disease LU Li-hua ；LIAO Tong ；LI Huan-lun ；GU Zhen-tuo Objective To investigate the effect of Spironolactone combined with Amlodipine Mesylate Tablets in the treatment of elderly hypertensive heart disease.Methods A total of 148 elderly patients with hypertensive heart disease treated in our hospital from January 2014 to January 2017 were selected and they were divided into the control group(n=74)and the observation group (n=74)according to the random digital table method.The control group was treated with routine treatment and nursing,and the observation group was treated with Spironolactone and Amlodipine Mesylate Tablets on the basis of the control group.The blood pressure (SBP,DBP),curative effect and LVEDVI,LVESVI,LVEDD,IVST,LVPWT indicators,VE/VA,LVEF,Tei index and other indicators before and after treatment of patients in the two groups were statistically analyzed.Results Before treatment,there is no significant difference in blood pressure between the two groups(P＞0.05).After treatment,the improvement of SBP and DBP level of the observation group is significantly higher than that in the control group (P＜0.05).The total effective rate of the observation group is 86.49%,which was obviously higher than that of the control group (59.46%)(P＜0.05).Before treatment,there are no significant differences in LVEDVI,LVESVI,LVEDD,IVST and VE/VA,LVEF,LVPWT index and Tei index(P＞0.05),after treatment,all parameters in the observation group were significantly improved (P＜0.05),only LVEDVI,LVESVI and LVEF index in the control group were improved significantly (P＜0.05),the degree of improvement in the observation group was higher than that of the control group (P＜0.05).Conclusion Spironolactone combined with Amlodipine Mesylate Tablets can effectively improve left ventricular hypertrophy and remodeling in hypertensive patients,is beneficial for relieving diastolic dysfunction,reduce blood pressure,and ensure the treatment effect of patients. 2018 Vol. 25 (13): 16-19 [Abstract] ( 158 ) HTML (38 KB)  PDF  (0 KB)  ( 25 ) 20 The role of general anesthetics and the mechanisms of hippocampal functions in the postoperative cognitive dysfunction WANG Chen； ZHANG Hong；SHEN Hao Preclinical investigations demonstrated that postoperative memory functions may be influenced by anesthetics,especially the spatial memory and learning functions of hippocampus.Different anesthetics may have different pathways and outcomes on postoperative cognitive functions.This review discuss the recent progress of anesthetics influence on postoperative hippocampal cognitive dysfunction,mainly in the pathways of structure basics,neuroinflammation,neuronal apoptosis,nerve conduction and blood brain barrier. 2018 Vol. 25 (13): 20-23 [Abstract] ( 157 ) HTML (40 KB)  PDF  (0 KB)  ( 31 ) 24 Research progress on comprehensive evaluation methods of severe trauma GENG Ya-hui；LIU Qiang The application of comprehensive score in the probability of survival(Ps)plays a key role in the modern trauma system.Ps in all severely trauma patients should be accurately assessed.However,the method for assessing Ps is not uniform among the trauma agencies in different countries.Germany′s revised injury severity classification-Ⅱ (RISCⅡ)and UK′s Ps-14 are based on the latest database of large samples and are more suitable for the trauma evaluation for European population.The updated and modified trauma and injury severity score(TRISS)is derived from the United States national database,which is the global standard for predicting outcome.However,trauma assessment based on blunt trauma is not accurate enough.A severity characterization of trauma (ASCOT)which is revised to make up for the lack of TRISS scores is theoretically more accurate in the value of prediction.Other comprehensive scores also have higher predictive values.The comprehensive evaluation methods are summarized as follows. 2018 Vol. 25 (13): 24-27 [Abstract] ( 160 ) HTML (43 KB)  PDF  (0 KB)  ( 29 ) 28 Analysis of application of multidisciplinary teamwork in the improvement of negative emotions in gastroenterology outpatients GUAN Jian-song； RONG Zhen-xiang ；LIANG Yu-tuan； MAI Xian-qiang Objective To explore the effect of multidisciplinary teamwork(MDT)in improvement of negative emotions in gastroenterology outpatients.Methods Altogether 80 patients with digestive diseases accompanied by mental disorder who were treated in outpatient department of gastroenterology of our hospital from July to December in 2017 were selected as the study group;another 75 patients with digestive diseases accompanied by mental disorder who were treated in our hospital from January to June 2017，were selected as the control group.The control group was received traditional diagnosis and treatment service;while,the study group were treated with MDT mode intervention.The effect was compared between the two groups.Results The post-treatment self-rating anxiety scale (SAS)and self-rating depression scale(SDS)scores of the study group were significantly lower than those before treatment（P＜0.001）.The SAS and SDS scores of the study group were significantly lower than those of the control group （P＜0.01）.The post-treatment total score of SF-36 (36-item short form health survey)of the control group was higher than that before the treatment.The post-treatment physical functioning(PF),general health(GH),vitality(VT),mental health(MH)and total score of the study group were significantly higher than those before the treatment（P＜0.05）.The post-treatment GH,VT,MH and total score of the study group were significantly higher than those of control group after treatment,the differences were statistically significant(P＜0.05).Conclusion Application of MDT mode in outpatient department of gastroenterology can significantly improve patient′s negative emotions and improve their health. 2018 Vol. 25 (13): 28-30转34 [Abstract] ( 169 ) HTML (35 KB)  PDF  (0 KB)  ( 34 ) 31 Evaluation of the clinical efficacy of sublingual immunotherapy with dermatophagoides farianae drops for allergic rhinitis JIANG Ze-bing； FANG Xiao-ming； LIN Si-ping ]Objective To evaluate clinical efficacy of sublingual immunotherapy with dermatophagoides farianae drops for allergic rhinitis of different age groups in Jieyang.Methods A total of 510 cases of allergic rhinitis were selected as the research object in our hospital from January 2016 to October 2016.The patients were divided into 6 groups according to age：preschool group(4-6 years old.36 cases),school age group(7-12 years old,89 cases),adolescent group(13-20 years old,143 cases),adolescence group(21-40 years old,126 cases),midlife group(41-60 years old,68 cases),old age group (more than 60 years old,48 cases).All patients were theapied with sublingual immunotherapy with dermatophagoides farinae drops in a year,and clinlcal symptom score,life quality scores and incidence rate of adverse were contrasted in every group before and after treatment.Results After treatment,clinlcal symptom score was lower than before treatment in 510 cases of patients,and clinical effective rate was 76.5%,and life quality was improved than before treatment(P＜0.05),30 cases(5.9%)occured local adverse reactions,24 cases(4.7%)occured slight whole body adverse reaction,clinlcal symptom score and life quality score with different age signs before treatment were (8.07±1.58)and(12.47±3.17)point,(8.12±1.63)and(12.58±3.09)point,(11±1.56)and(12.39±3.11)point,(8.09±1.60)and(12.60±3.15)point,(8.15±1.65)and (12.51±3.08)point,(8.17±1.59)and (12.49±3.13)point respectively,and after treatment were(4.68±1.59)and (8.47±2.64)point,(4.74±1.63)and(8.51±2.51)point,(4.71±1.67)and (8.49±2.58)point,(4.67±1.52)and(8.62±2.61)point,(4.62±1.55)and(8.53±2.66)point,(4.80±1.64)and(8.59±2.55)point,and clinlcal symptom score and life quality score was statistically difference before treatment than after treatment(P＜0.05).Clinlcal symptom score and life quality score was lower at 6 months after treatment than before treatment(P＜0.05),and which was lower at 12 months after treatment than at 6 months after treatment(P＜0.05).ConclusionSublingual immunotherapy with dermatophagoides farianae drops is an effective and high safety method for the treatment of allergic rhinitis.It is worthy of extensive promotion and application,and equivalent efficacy could be achieved for different age groups. 2018 Vol. 25 (13): 31-34 [Abstract] ( 153 ) HTML (37 KB)  PDF  (0 KB)  ( 31 ) 35 Effect study of Levofloxacin combined with conventional anti-tuberculosis therapy on AIDS complicated with tuberculosis CHEN Ting-xian；CHEN Yong-yi；HUANG Xiu-huo；DAI Fen Objective To investigate the clinical effect of Levofloxacin combined with conventional anti-tuberculosis therapy on AIDS patients with pulmonary tuberculosis.Methods A total of 42 patients with HIV-positive pulmonary tuberculosis admitted to Yangjiang Public Health Hospital from January 2014 to December 2016 were randomly divided into control group and treatment group,21 cases in each group.The control group received conventional anti-tuberculosis therapy.The treatment group was treated with Levofloxacin and routine anti-tuberculosis treatment,the clinical effect of two groups of patients were analyzed and compared.Results The total effective rate of the treatment group was significantly higher than that of the control group(P＜0.05);the sputum negative conversion rate of the treatment group was higher than that of the control group(P＜0.05);the treatment group improved MRC dyspnea score,1 seconds rate,6-minute walk distance were significantly higher than that in the control group,indicated that the respiratory function of the treatment group was better than that of the control group,the differences were statistically significant(P＜0.05).The incidence of adverse reactions in the treatment group was 42.86%,the incidence of adverse reactions in the control group was 38.10%.There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion Levofloxacin combined with conventional anti-tuberculosis therapy in patients with AIDS-associated pulmonary tuberculosis is not only effective,but also has a small adverse reaction，and can be used as a new generation of anti-TB drugs,especially in the treatment of tuberculosis in special populations. 2018 Vol. 25 (13): 35-37转41 [Abstract] ( 142 ) HTML (37 KB)  PDF  (0 KB)  ( 29 ) 38 Clinical effect of glucocorticoid and bronchodilator in the treatment of patients with long-term poorly controlled asthma DONG Zhen-ling Objective To explore the clinical efficacy of glucocorticoid and bronchodilator in the treatment of patients with long-term poorly controlled asthma.Methods From July 2015 to March 2017,104 asthma patients treated in our hospital were evenly divided into routine group and research group according to different therapeutic regimen.In the routine group,bronchodilator was used.In the research group,on the basis of using bronchodilator,glucocorticoid was added for intervention.The clinical total effectiveness rate,serum IL-8 and TNF-α levels,and hospital stay were compared in the two groups.Meanwhile,the indexes of pulmonary function and the incidence of adverse drug reactions were compared between the two groups.Results In the research group,the total effectiveness rate was 96.15%,which was significantly higher than that in the routine group accounting for 82.69%with a statistical difference(P＜0.05).The levels of serum IL-8 and TNF-α in research group were greatly lower than those in the control group(P＜0.05).With regard to hospital stay in the rcsearch group,was sherter than that in the routine group,with statistical difference (P＜0.05).In the research group,the incidence of adverse reactions was 5.77%,which was much lower than that in the routine group accounting for 26.92%with a statistical difference (P＜0.05).The pulmonary function indexes including FEV1and PFE in the research group were displayed than that in the rautine group,with a statistical significance (P＜0.05).Conclusion Compared with single medication,combination of glucocorticoid and bronchodilator can effectively alleviate the clinical symptoms of patients with long-term poorly controlled bronchial asthma,decrease the levels of serum IL-8 and TNF-α,improve the pulmonary function,shorten the hospital stay,and further improve the clinical efficacy with advantages of absence of obvious toxic and side effects and high drug safety,which has clinical significance and application value. 2018 Vol. 25 (13): 38-41 [Abstract] ( 172 ) HTML (38 KB)  PDF  (0 KB)  ( 35 ) 42 Clinical effect of rehabilitation intervention in the treatment of patients with stroke complicated with shoulder-hand syndrome XIA Yang；ZHANG Wen-cui Objective To comprehensively analyze the clinical effect of rehabilitation intervention in the treatment of patients with stroke and shoulder-hand syndrome.MethodsA total of 80 cases of stroke complicated with shoulderhand syndrome who were treated in Guangzhou Yikang Geriatrics Hospital from October 2014 to October 2016 were selected as research subjects.They were randomly divided into experimental group(rehabilitation therapy intervention)and control group (conventional intervention treatment)according to admission order,40 cases in each group.The clinical efficacy,total satisfaction score of nursing and scores of indicators(activities of daily living,limb motor function score,visual analogue pain score)before and after rehabilitation nursing intervention were compared between the two groups.Results The total effective rate in the experimental group was 92.50%(37/40),the total effective rate in the control group was 72.50%(29/40),and the total effective rate in the experimental group was significantly higher than that in the control group(P＜0.05);the total satisfaction score in the experimental group was significantly higher than that in the control group(P＜0.05);before rehabilitation nursing intervention,there was no statistically significant difference in the activities of daily living，limb motor function scores and visual analogue pain score between the two groups(P＞0.05);after rehabilitation nursing intervention,the activities of daily living,limb motor function scores and visual analogue pain scores in the experimental group were significantly better than those in the control group,the differences were statistically significant(P＜0.05).Conclusion Rehabilitation therapy intervention has a significant clinical effect in patients with stroke complicated with shoulder-hand syndrome and improves limb function significantly. 2018 Vol. 25 (13): 42-44 [Abstract] ( 160 ) HTML (34 KB)  PDF  (0 KB)  ( 24 ) 45 Curative effect of tricuspid valvuloplasty with domestic valve ring during the same period of valve replacement XU Fa-zhen；CHEN Kai-ming； JIANG Zhen-qiang；WU Yi-zhong；ZHOU Yan-bin Objective To investigate the clinical value of domestic Bairensi tricuspid valve ring implantationoperation.Methods From July 2014 to February 2017,84 patients undergone tricuspid valvuloplasty (TVP)in our hospital and Gaozhou People′s Hospital of Guangdong Province were selected.According to the surgical methods,they were divided into the experimental group(n=42)and control group(n=42).In the experimental group,the valvuloplasty protocol was used,while in the control group,De Vega plasty was adopted.The results of postoperative cardiac function grading and cardiac uhrasonography were compared in patients between the two groups.Results The postoperative cardiac function grading of the two groups were significantly better than those before operation with statistical differences(P＜0.05).The ultrasound parameters one week after surgery in the two groups were all superior to those before surgery with statistical significance (P＜0.05).The long-term ultrasound parameters were significantly better in the experimental group than the control group,which displayed statistical significance (P＜0.05).After half a year follow up visits,on severe tricuspid regurgitation occurred in the experimental group,while in the control group,5 cases occurred,and even 1 dead among them.The incidence of severe tricuspid regurgitation in the experimental group and control group was 0%and 11.9%respectively among them.The incidence of postoperative complications in the experimental group was significantly less than that in the control group with statistical significance(P＜0.05).Conclusion In the treatment of tricuspid incompetence,domestic Bairensi tricuspid valve ring implantation has a definite effect,which is basically the same as that of De Vega plasty.It can effectively reduce the incidence of severe tricuspid regurgitation and improve the operation safety,and ameliorate the postoperative quality of life of patients. 2018 Vol. 25 (13): 45-47 [Abstract] ( 153 ) HTML (36 KB)  PDF  (0 KB)  ( 28 ) 48 Correlation study between heart rate variability and target-organ damage in elderly hypertension WEI Li-li Objective To explore the correlation between heart rate variability (HRV)and target-organ damage in elderly hypertension.Methods From July 2015 to February 2017,a total of 135 elderly patients with hypertension treated in our hospital were enrolled as research objects.According to whether their clinical examinations were accompanied by target-organ damage or not,they were divided into the two groups：the control group (n=48,having no target-damage in hypertension)and observation group(n=87,having hypertension with target-organ damage).Examinations such as cardiac ultrasound,24-hour electrocardiogram,blood biochemistry,and carotid artery ultrasound were performed in the two groups.Time-domain analysis of HRV was carried out,and the analysis of HRV included the mean standard deviation(SDNNindex)of 5-min RR interval,root mean square of adjacent RR interval difference(RMSSD),and 24 h mean SD interval of normal sinus beats(SDNN),etc.Intima-media thickness(IMT),microalbunminuria(MAU),left ventricular mass index (LVMI)and creatinine (Cr)level in patients between the two groups were compared.Results The level of IMT,MAU,LVMI and Cr level were significantly different between the observation group and the control group (P＜0.05).The RMMSD,SDANN,SDNN,PNN50 value in the observation group were significantly lower than those of the control group(P＜0.05).HRV level were negatively correlated with Cr,LVMI,and IMT in patients of the observation group(r=-0.36,-0.39,-0.49,P＜0.05).Conclusion When target-organ damage occurs in elderly patients with hypertension,the value of HRV detection in clinic will be significantly reduced,and the greater the decrease is,the more severe the target-organ damage becomes. 2018 Vol. 25 (13): 48-50 [Abstract] ( 160 ) HTML (35 KB)  PDF  (0 KB)  ( 24 ) 51 Comparison of diagnostic value of dynamic electrocardiogram and conventional electrocardiogram for myocardial ischemia and arrhythmia in coronary heart disease YANG Fa；SU Ming-lan；ZHANG Bin；LI Xiao-zhu Objective To explore the diagnostic value of dynamic electrocardiogram (ECG)and conventional ECG on myocardial ischemia and arrhythmia in coronary heart diseases(CHD).Methods The clinical data of 140 patients with CHD admitted into our hospital from January 2015 to December 2017 were analyzed.According to different examination methods,they were divided into group A(dynamic ECG)and group B(conventional ECG).All patients were confirmed by coronary angiography.Results The positivity rate of diagnosis of myocardial ischemia in group A was higher than that of group B.The proportions of diagnosis of ventricular arrhythmia,atrial arrhythmia,atrioventricular conduction block,and paroxysmal supraventicuar tachycardiain in group A were significantly higher than those in group B,which were all displayed statistical differences(P＜0.05).Conclusion The positivity rate of myocardial ischemia and arrhythmia diagnosed by dynamic ECG are significantly higher compared with those using conventional ECG,which is worthy of clinical application and promotion. 2018 Vol. 25 (13): 51-53 [Abstract] ( 166 ) HTML (32 KB)  PDF  (0 KB)  ( 32 ) 54 The influence of differing administration time on blood pressure circadian rhythm and morning blood pressure surge in hypertension patients over 80 years old MA Bo-cong；ZHAO Ming Objective To investigate the influence of differing administration time on blood pressure circadian rhythm and morning blood pressure surge in hypertension patients over 80 years old.Methods The ambulatory blood pressure monitoring was carried out on patients over 80 years old treated in our hospital from June 2014 to June 2015.The dozing-time of long-acting antihypertensive on patients with non-dipper type blood pressure was adjusted from morning to night,and ambulatory blood pressure monitoring was carried out again after 2 weeks.Results Compared with the morning dozing schedule,taking long-acting anti-hypertention drugs at evening having similar BP lowering effect(P＞0.05).In elderly hypertensive patients,taking anti-hypertensive at evening effectively improve the morning blood pressure surge(P＜0.05)and the control rate of morning peak of blood pressure was 83%.Conclusion In hypertension patients over 80 years old,compared with morning dosing schedule,although the circadian rhythm of blood pressure is not significantly changed,taking long-acting anti-hypertensive drugs at evening have similar BP lowering effect,and effectively control the morning blood pressure surge. 2018 Vol. 25 (13): 54-56转60 [Abstract] ( 141 ) HTML (36 KB)  PDF  (0 KB)  ( 30 ) 57 Relevance between the incidence of acute and transient psychotic disorders and seasonal and meteorological factors REN Yan-zhen；DU Bao-guo；LAO Zhao-ming Objective To investigate the seasonal characteristics of the onset of acute and transient psychotic disorders and their correlation with meteorological factors.Methods A retrospective analysis was performed on the medical records of 464 patients with acute and transient psychotic disorders who were discharged from June 2010 to May 2017 in the Third People′s Hospital of Zhongshan City.The seasonal characteristics of monthly hospital admissions were explored.The correlation analysis was carried out on the mean temperature,temperature difference,barometric pressure,humidity,wind speed,sunshine duration,precipitation and other meteorological factors in the same month.Results The amount of monthly admissions for acute and transient psychotic disorder was increased significantly during the early spring(March-April),early autumn (September-October)and early winter(December)seasons,and the amount was relatively low in the summer(June-August).Chi-square test with composition ratios was carried out on the basis of the total admissions in the season indicated that the composition ratio of acute and transient psychotic disorders in spring and autumn was higher than that in summer(P＜0.05).Pearson correlation analysis showed that the monthly admissions of the patients with acute and transient psychotic disorders were positively correlated with the mean monthly barometric pressure(P＜0.05),and were negative correlated with the mean monthly wind speed(P＜0.01).Conclusion There is a significant seasonal feature in the incidence of acute and transient psychotic disorders.Alternation of seasons and meteorological factors such as air pressure and wind speed may affect its incidence. 2018 Vol. 25 (13): 57-60 [Abstract] ( 158 ) HTML (38 KB)  PDF  (0 KB)  ( 28 ) 61 Application effect of high quality first aid measures in emergency internal medicine in patients with cerebral hemorrhage XIA Zhi-yu Objective To investigate the effect of high-quality first-aid measures in emergency internal medicine in patients with cerebral hemorrhage.Methods A retrospective analysis was performed on 60 patients with cerebral hemorrhage in emergency internal medicine admitted to our hospital from February 2015 to January 2016.According to different first aid protocols,they were divided into observation group(n=30)and control group(n=30).In the control group,conventional measure in emergency internal medicine department was used,while in the observation group,high-quality first-aid measure was adopted.The clinical effect of the two groups was compared.Results The rescue success rate of the observation group(96.67%)was higher than that of the control group(76.67%).The neurological deficit score([7.13±1.23]points)and mortality (3.33%)after treatment in the observation group were lower than those in the control group([10.66±1.54]points,23.33%),the differences were statistically significant(P＜0.05).Conclusion The implementation of high-quality first-aid intervention in patients with cerebral hemorrhage in emergency optimizes procedures,monitors their vital signs,judges their consciousness,establishes venous and respiratory pathways,which plays positive significance in controlling the blood pressure and encephaledema,thus increasing the rescue success rate and ensuring the life safety,and is worth promoting in the clinical practice. 2018 Vol. 25 (13): 61-63 [Abstract] ( 137 ) HTML (32 KB)  PDF  (0 KB)  ( 37 ) 64 Clinical effect observation of early lumbar cistern drainage in treatment of intraventricular and subarachnoid hematoma LIU Ying-bin ；ZHANG Li-xing ；PENG Jun-long Objective To study the clinical effect of early lumbar cistern drainage in patients with intraventricular and subarachnoid hematomas.Methods A total of 106 patients with intraventricular and subarachnoid hematoma treated in our hospital from March 2015 to February 2017 were selected as research subjects.According to random table method,they were evenly divided into research group and control group,53 cases in each group.The control group was treated with routine treatment.In the research group,on the basis of the control group,early application of lumbar cistern drainage was used.The incidence of post-treatment complications and quality of life score were observed in all patients,and the clinical efficacy of the two groups was compared.Results The total effective rate in the research group(92.45%)was higher than that in the control group(81.13%),the difference was statistically significant(P＜0.05).The incidence of secondary hydrocephalus,cerebral vasospasm,epilepsy,and cerebral infarction in the research group were lower than those in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in quality of life scores between the two groups before treatment(P＞0.05).After therapy,the quality of life score in the research group was higher than that of the control group,the difference was statistically significant(P＜0.05).Conclusion For intraventricular and subarachnoid hematoma patients,on the basis of routine treatment,early application of lumbar cistern drainage obtains a favorable effect.It can effectively prevent secondary hydrocephalus,improve the therapeutic effect in high safety,ameliorate the quality of life,and guarantee prognosis. 2018 Vol. 25 (13): 64-66 [Abstract] ( 155 ) HTML (33 KB)  PDF  (0 KB)  ( 28 ) 67 Effect of different blood purification methods on thyroid related hormones in uremic patients SUN Ming；LIU Ye-wei；SUN Yi-jun；WU Wen-bin； YU Shu-jun Objective To investigate the changes of free triiodothyronine(FT3),free thyroxine(FT4),and thyroid stimulating hormone(TSH)in uremic patients undergone hemodialysis(HD)and peritonial dialysis(PD)to explore the influence of two different blood purification methods on thyroid related hormones.Methods From January 2011 to December 2014,108 patients in Department of Nephrology,Weifang Yidu Central Hospital and Weihai Traditional Chinese Medicine Hospital were selected as the subjects,and divided into HD group(59 cases)and PD group(49 cases)according to the patients′and their families′wills.The venous blood samples at the early morning were collected before dialysis and 6 months after dialysis in order to detect the concentrations of serum FT3,FT4,and TSH.Results There was no significant difference in FT3,FT4,and TSH levels between before and after treatment in HD group (P＞0.05).The level of serum FT3in PD group after therapy was significantly higher than that before treatment,the difference was statistically significant(P＜0.01).After therapy,the level of serum FT3in PD group was higher than that in HD group,the difference was statistically significant(P＜0.05).The level of serum FT4in PD group was lower than that before treatment with a statistical difference(P＜0.05).The level of serum FT4in PD group was lower than that in HD group after therapy (P＜0.05).For serum TSH levels between before and after treatment in PD group,no significant difference was displayed(P＞0.05).Conclusion HD has no significant effect on thyroid-related hormone levels in patients with uremia.PD can increase serum FT3,reduce the harm of T3in low level to a certain extent,and also lead to a decrease of FT4.The two different therapeutic methods have no impact on thyroid-pituitary feedback circuit. 2018 Vol. 25 (13): 67-69 [Abstract] ( 138 ) HTML (40 KB)  PDF  (0 KB)  ( 34 ) 70 Effect observation of Finasteride combined with Terazosin in treatment of benign prostatic hyperplasia HUA Wei；XI Ming；WAN Song；ZENG Shao-cHang；WAN Yue-ping Objective To study the clinical effect of finasteride combined with terazosin in treatment of benign prostatic hyperplasia.Methods A total of 120 patients with benign prostatic hyperplasia treated in our hospital from March 2015 to March 2017 were selected as the subjects.They were evenly divided into control group and treatment group by random grouping.In the control group,Terazosin was used,while in the treatment group,combination of Terazosin and Finasteride was adopted.The indexes of urodynamics including PVR,Qmaxand VMCC before and after therapy,improvement of prostate symptom and quality of life score,total effectiveness rate of BPH drug,drug-induced adverse reactions,time of urinary function return to normal and total time of medical treatment in the two groups were compared.Results In the treatment group,the improvement of PVR,Qmaxand VMCC in urodynamics,prostate symptom and quality of life before and after treatment were significantly more obvious than those in the control group,the differences were statistically significant(P＜0.05).The total effectiveness rate of BPH was 91.7%,higher than 70.0%in the control group,with a statistical difference(P＜0.05).The rate of drug-induced adverse reactions in the treatment group(5.0%)was less than that in the control group(18.3%),the difference was statistically significant(P＜0.05).The urinary function recovery time and the total duration of treatment were both shorter than those in the control group,the difference was statistically significant(P＜0.05).ConclusionFor BPH patients,application of finasteride can significantly improve the patient′s urinary function,control the symptoms,ameliorate patient′s quality of life,shorten the clinical treatment time,reduce the adverse reactions,and fundamentally improve the therapeutic effect of BPH. 2018 Vol. 25 (13): 70-72转91 [Abstract] ( 173 ) HTML (38 KB)  PDF  (0 KB)  ( 33 ) 73 Comparison of the effects of retrograde catheter drainage and percutaneous nephrostomy in emergency treatment of ureteral calculi combined with urinary sepsis TAN Yi-yuan；LIN Yu；XIONG Mang；GUO Hui；PAN Wei-min；HU Jian-yue Objective To compare the efficacy of retrograde catheter drainage and percutaneous nephrolithotomy in the emergency treatment of ureteral calculi complicated with urinary sepsis.Methods Eighty patients with ureteral calculi complicated with urinary sepsis admitted to the emergency department of the First People′s Hospital of Shaoguan City from January 2011 to January 2017 were selected as the subjects,and divided into two groups by average,40 cases in each group.The control group was treated with percutaneous nephrostomy drainage,and the patients in the research group were treated by retrograde catheter drainage for emergency treatment.Urinary sepsis control time,drainage success rate and complication rate were compared between the two groups.Results There was no significant difference in postoperative urinary sepsis control time and incidence of complications between the two groups(P＞0.05).The success rate of drainage in research group was significantly higher than that in control group,the difference was significant(P＜0.05).Conclusion In the emergency treatment of ureteral calculi combined with urinary sepsis,the application of retrograde catheter drainage and percutaneous nephroureterectomy can effectively control the progression of urinary sepsis and avoid the occurrence of more postoperative adverse reactions in patients Complications,but the success rate of retrograde catheter drainage is higher,therefore,in order to ensure that patients can get timely emergency treatment,may be preferred by retrograde catheter drainage. 2018 Vol. 25 (13): 73-75 [Abstract] ( 161 ) HTML (34 KB)  PDF  (0 KB)  ( 33 ) 76 Clinical application of balloon dilation in the treatment of ureteral calculi and stenosis GUAN De-jia Objective To investigate the clinical effect of balloon dilation in the treatment of ureteral calculi and stenosis.Methods One hundred patients with ureteral calculi and stenosis treated in our hospital from March 2015 to March 2018 were selected as the study subjects,and divided into two groups radomly.Patients in the control group were treated with conventional intracavitary dilation surgery.Patients in the observation group were treated with balloon dilation and minimally invasive surgery.The cure rate,operation time,intraoperative blood loss,postoperative gastrointestinal recovery time,treatment time were compared between the two groups.Results There was no significant difference in the cure rate between the observation group (84.00%)and the control group (82.00%)(P＞0.05).The operation time,gastrointestinal recovery time,treatment time in the observation group were significantly shorter than those in the control group,intraoperative blood loss was less than the control group,the differences were statistically significant(P＜0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion The effect of conventional intracavitary dilation surgery and balloon dilatation minimally invasive surgery is similar to that of ureteral stricture.However,the operation of balloon dilatation and minimally invasive surgery is simpler,which can shorten the operation time,less bleeding during operation,rapid recovery of postoperative gastrointestinal function,and can shorten the hospital stay,which is worth promoting. 2018 Vol. 25 (13): 76-78 [Abstract] ( 142 ) HTML (34 KB)  PDF  (0 KB)  ( 26 ) 79 Clinical Study of Zhenbaokang Antibacterial Gel TypeⅢcombined with Roxithromycin in the treatment of chronic nonbacterial prostatitis YANG Ya-zhang Objective To investigate the clinical effect of Zhenbaokang Antibacterial Gel TypeⅢcombined with roxithromycin in the treatment of chronic nonbacterial prostatitis.Methods A total of 356 patients with chronic nonbacterial prostatitis who were admitted to our hospital from April 2016 to March 2017 were selected as study subjects,and divided into control group (178 cases)and observation group (178 cases)by radom table method.The control group was treated with Roxithromycin capsules.The observation group was combined with the Zhenbaokang Medical antibacterial Gel for anal treatment on the basis of the control group.The NIH-CPSI scores,the item scores and effictive rates of the two groups were compared.Results There was no significant difference in pain or discomfort score,urination symptom score,quality of life score,and total score before treatment between the two groups(P＞0.05).Pain or discomfort score,urination symptom score,total score in the treatment group after treatment were lower than those in the control group,the difference was statistically significant(P＜0.05).After treatment,the quality of life score was higher in the treatment group than that in the control group (P＜0.05).The effective rate in the treatment group (94.9%)was higher than that in the control group(56.7%),the difference was statistically significant(P＜0.05).Conclusion Zhenbaokang Medical Antibacterial Gel combined with Roxithromycin treatment of chronic prostatitis can help improve the symptoms of patients,improve the quality of life and efficacy of patients,which is worthy of clinical application. 2018 Vol. 25 (13): 79-81 [Abstract] ( 203 ) HTML (33 KB)  PDF  (0 KB)  ( 35 ) 82 Application value of 3D printing technique in pelvic fracture repair LAN Xiao-yong ；ZHANG Zhi-ping； YE Dong； LIAO Xue-qin Objective To investigate the value of 3D printing technique in pelvic fracture repair.Methods From January 2015 to May 2016,42 patients with pelvic fracture were selected as the research object.The patients were divided into control group and observation group by random number table,with 21 cases in each group.The patients in the observation group underwent CT scan before repair,and the pelvis model was printed with 3 D technology according to the size of 1：1 with the entity.the preoperative evaluation,planning and repair design were carried out.The patients in the control group were treated with conventional pelvic fracture repair methods.The pelvic fracture repair surgery,regular review of fracture healing and reduction were analyzed.Results The amount of intraoperative blood loss and intraoperative blood transfusion in the observation group was significantly less than that in the control group,and the operation time was shorter than that in the control group,the differences were statistically significant(P＜0.05).The incidence of postoperative complications in the observation group(0)was significantly lower than that in the control group(38.10%),the difference was statistically significant(χ2=9.882,P=0.002).There was no significant difference in the excellent and good rate of reduction between the two groups(χ2=1.273,P=0.259).Conclusion For patients with pelvic fracture repair preoperative evaluation,planning and repair,3D printing technology can be used to determine the displacement of the fracture,facilitate the precise operation of the operation,is conducive to shorten the operation time and reduce the amount of bleeding,complications,etc.,3D printing technology can be effective for pelvic fracture repair preoperative evaluation and planning. 2018 Vol. 25 (13): 82-84 [Abstract] ( 144 ) HTML (37 KB)  PDF  (0 KB)  ( 27 ) 85 Effect observation of anatomic locking plate and retrograde intramedullary nail internal fixation in the treatment of supracondylar femoral fracture TAN Xiao-bo； WAN Bin ；WANG Jin-ping ；LI Yun-hua； MO Shi-zan； ZHANG Bi-yun Objective To investigate the effect of anatomic locking plate and retrograde intramedullary nail internal fixation in the treatment of supracondylar femoral fractures.Methods From January 2014 to March 2017,65 cases of supracondylar fracture of femur were divided into anatomical locking plate fixation group(30 cases)and retrograde intramedullary nail fixation group(35 cases).The operation time,bleeding volume,fracture healing time and clinical efficacy of the two groups of patients with femoral supracondylar fracture were observed.Results The operation time and fracture healing time in retrograde intramedullary nail fixation group were shorter than those in anatomic locking plate fixation group,and the amount of bleeding was less than that in anatomic locking plate fixation group,the differences were statistically significant(P＜0.05).The excellent and good rate of retrograde intramedullary nail fixation group was higher than that of anatomical locking plate fixation group,the difference was statistically significant.Conclusion The retrograde intramedullary nail internal fixation in the treatment of patients with supracondylar femoral fractures has advantages of small trauma,short operation time and good prognosis,which is worthy of clinical promotion and application. 2018 Vol. 25 (13): 85-87 [Abstract] ( 116 ) HTML (31 KB)  PDF  (0 KB)  ( 30 ) 88 Clinical effect of nourishing blood and relaxing tendons decoction combined with decubitus balance manipulation in the treatment of vertebral artery type of cervical spondylosis OU Zhi-jian Objective To investigate the difference between application of Nourishing Blood and Relaxing Tendons Decoction plus decubitus balance manipulation and Nimodipine plus decubitus balance manipulation in the treatment of vertebral artery type of cervical spondylosis.Methods Sixty-four patients with vertebral artery type cervical spondylosis admitted to our hospital from June 2015 to June 2017 were selected for clinical study.They were divided into control group and observation group with 32 cases in each group by random number table method.The observation group was treated with Yangxue Shujin decoction，while the control group was treated with nimodipine.Both groups were treated with horizontal balance manipulation for six weeks.After one course of treatment，the clinical efficacy，hemorheology indexes （whole blood viscosity，plasma viscosity，hematocrit，plasma fibrinogen）and vertebral artery blood flow，mean blood flow velocity，vertebral artery blood vessel diameter measured by transcranial Doppler （TCD）before and after treatment were observed.Results The total effective rate in the observation group was higher than that in the control group，the difference was statistically significant （P＜0.05）.After treatment，the hemorheology indexes of the two groups were significantly improved compared with those before treatment （P＜0.05）.The improvement degree of hemorheology index in the observation group was better than that in the control group，the difference was statistically significant （P＜0.05）.TCD detection indexes of the two groups were significantly improved after treatment compared with those before treatment （P＜0.05）.The improvement degree of TCD in observation group was better than that in control group after treatment，the difference was statistically significant （P＜0.05）.Conclusion Application of combination of Nourishing Blood and Relaxing Tendons Decoction plus decubitus balance manipulation has better effect in treatment of vertebral artery type of cervical spondylosis，which can effectively improve hemorheology and TCD-related indexes，and is worthy of clinical promotion. 2018 Vol. 25 (13): 88-91 [Abstract] ( 154 ) HTML (33 KB)  PDF  (0 KB)  ( 30 ) 92 The effect of total knee arthroplasty combined with Zhitong Siwu Decoction in the treatment of osteoarthritis of the knee and its effect on the serum CRP level of the patients CHEN Chuan-yuan；LI Han-jing Objective To investigate the effect of total knee arthroplasty combined with Zhitong Siwu Decoction on knee osteoarthritis and its influence on serum C reactive protein(CRP)level.Methods From January 2013 to January 2015,88 patients with knee osteoarthritis in our hospital were selected and randomly divided into control group and observation group,with 44 cases in each group.The control group was treated with total knee arthroplasty,while the observation group was treated with Zhitong siwu decoction on the basis of the control group.CRP level,IL-1 level,knee flexion,HSS score and clinical efficacy were compared between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).The levels of CRP and IL-1 in the two groups were lower than those before treatment.the levels of CRP and IL-1 in the observation group were lower than those in the control group,the difference was statistically significant(P＜0.05).After treatment,the knee flexion and HSS score of the two groups were higher than those before treatment,and the knee flexion and HSS score of the observation group were higher than those of the control group,the difference was statistically significant(P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).Conclusion Total knee arthroplasty combined with Zhitong Siwu Decoction can effectively improve the therapeutic effect of knee osteoarthritis,it can improve the score of knee joint,and has high safety,which is worthy of clinical application. 2018 Vol. 25 (13): 92-94 [Abstract] ( 128 ) HTML (36 KB)  PDF  (0 KB)  ( 25 ) 95 Effect comparison of interlocking intramedullary nail and locking plate internal fixation on femoral fractures in adults CHEN Jian-cheng ；LIANG Yong-ge； XIE Wen-feng Objective To investigate the effect of interlocking intramedullary nail and locking plate fixation in the treatment of adult femoral fracture.Methods From January 2013 to January 2015,80 cases of adult femoral fracture patients were selected and randomly divided into control group and observation group,40 cases in each group.Patients in the control group were treated with locking plate internal fixation,while patients in the observation group were treated with interlocking intramedullary nail internal fixation.The therapeutic effects of two internal fixation schemes were compared.Results The operative time and fracture healing time in the observation group were significantly lower than those in the control group,and the amount of operative bleeding in the observation group was less than that in the control group,the differences were statistically significant （P＜0.05）.The excellent and good rate of the observation group was significantly higher than that of the control group,the difference was statistically significant（P＜0.05）.The incidence of complications in the observation group was significantly lower than that in the control group,the difference was statistically significant（P＜0.05）.Conclusion It is detected adult femoral fractures with interlocking intramedullary nails and locking plate internal fixation both aid on the bone fracture recovery to some extent,but the effect with interlocking intramedullary nail is relatively better and has advantages of surgical trauma improvement and amelioration of postoperative recovery,which is worthy of promotion. 2018 Vol. 25 (13): 95-97 [Abstract] ( 132 ) HTML (34 KB)  PDF  (0 KB)  ( 26 ) 98 Clinical study of small incision fenestration in the treatment of lumbar disc herniation complicated with lumbar spinal stenosis LIAO Qiang Objective To investigate the clinical effect of small incision fenestration in the treatment of lumbar disc herniation with lumbar spinal stenosis.Methods From November 2016 to November 2017,82 patients with lumbar disc herniation combined with lumbar spinal stenosis were selected and randomly divided into reference group and study group,41 cases in each group.The control group was treated with conventional treatment and the study group was treated with small incision fenestration.the total effective rate,VAS and JOA scores of the two groups were compared and analyzed.Results The total effectiveness rate of treatment group was significantly higher than that of the reference group,the difference was statistically significant(P＜0.05).The VAS score in the study group was lower,and the JOA score was higher compared with those in the reference group with statistical significance,the differences were statistically significant(P＜0.05).Conclusion Compared with the conventional treatment,for patients with lumbar disc herniation complicated with lumbar spinal stenosis,the small incision fenestration has a better therapeutic effect with a faster recovery of lumbar nerve and milder pain. 2018 Vol. 25 (13): 98-100 [Abstract] ( 120 ) HTML (31 KB)  PDF  (0 KB)  ( 27 ) 101 Therapeutic effect of compression screw fixation combined with tension band fixation in the treatment of patellar fracture LIU De-hua； TANG Ji-ping； LIN Chun-yang； YANG Hong-jie； XIANG Xiao-wei；ZHOU Li Objective To investigate the effect of cannulated screw fixation combined with tension band fixation in the treatment of patellar fracture.Methods Sixty patients with patellar fracture admitted to our hospital from August 2016 to August 2017 were selected as the research object,and randomly divided into control group and observation group,with 30 cases in each group.The control group was treated with kirschner wire tension band,while the observation group was treated with compression cannulated screw combined with steel wire tension band.The operation time,intraoperative blood loss,bed time,hospitalization time,fracture healing time,pain score,LKSS score,knee joint activity,Oswestry dysfunction index and complication rate were compared between the two groups.Results The operation time,bed time,hospitalization time and fracture healing time in the observation group were shorter than those in the control group,and the differences were statistically significant(P＜0.05),and the intraoperative blood loss in the observation group was lower than that in the control group,the difference was statistically significant （P＜0.05）.After operation,oswestry dysfunction index score and pain score of the two groups were lower than those of the control group (P＜0.05),LkSS score and knee joint activity were higher than those of the control group,the differences were statistically significant(P＜0.05).The incidence of complications in the observation group was lower than that in the control group (P＜0.05).Conclusion The treatment of patellar fracture with cannulated screw fixation and wire tension band is effective in improving the joint function,reducing the incidence of complications and improving the quality of life of patients with high clinical value. 2018 Vol. 25 (13): 101-103 [Abstract] ( 143 ) HTML (33 KB)  PDF  (0 KB)  ( 27 ) 104 Comparison of the effect of total laparoscopic and total abdominal hysterectomy in the treatment of uterine fibroids LUO Li；SUN Fang； LUO Shi-fang； JIANG Fu-can Objective To investigate the efficacy of total laparoscopic and total abdominal hysterectomy in the treatment of uterine fibroids and its effects on hormone levels and pelvic floor function.Methods From February 2014 to June 2017,64 patients with hysteromyoma were selected and randomly divided into two groups：laparoscopic total hysterectomy(TLH)group (observation group)and abdominal total hysterectomy (TAH)group (control group),32 cases in each group.The observation group was treated with tlh and the control group was treated with TLH.The perioperative indexes(operation time,intraoperative blood loss,postoperative pain time,hospitalization time),complications during hospitalization,pelvic floor function(pelvic floor muscle strength,urine leakage,sexual function[(FSFI)]at 3 months after operation were recorded.the levels of hormone(follicle stimulating hormone(FSH),luteinizing hormone(LH)before operation and 3 months after operation were compared between the two groups.Results The operation time of the observation group was longer than that of the control group(P＜0.05),but the intraoperative blood loss was less than that of the control group(P＜0.05),the postoperative pain time and hospitalization time of the observation group were shorter than those of the control group,the differences were statistically significant(P＜0.05).The total incidence of complications in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).At 3 months after operation,the pelvic floor muscle strength and FSFI score in the observation group were higher than those in the control group,and urine leakage was lower than that in the control group,The differences were statistically significant (P＜0.05).There was no significant differ-ence in FSH and LH levels between the two groups(P＞0.05).At 3 months after operation,FSH and LH levels in the two groups were lower than those in the control group,the differences were statistically significant(P＜0.05).Conclusion The TLH procedure has a smaller effect on postoperative ovarian function and pelvic floor function in patients with uterine fibroids than the TAH procedure,with fewer complications and significant surgical results,which will benefit the patients recovering from surgery. 2018 Vol. 25 (13): 104-107 [Abstract] ( 136 ) HTML (38 KB)  PDF  (0 KB)  ( 27 ) 108 Investigation and analysis of primary diseases in 355 neonatal hyperbilirubinemia cases CAI Yan-hong ；GUO Wei-zhong ；ZENG Zhen-hua Objective To investigate the prevalence of primary diseases leading to neonatal hyperbilirubinemia and analyze the characteristics of their respective cases in order to guide clinical observation,identify the cause of the diseases as early as possible,treat the cause,and prevent the disease progression and the occurrence of bilirubin encephalopathy.Methods From January to December 2017,the primary diseases in 355 neonatal hyperbilirubinemia cases hospitalized in Department of Neonatology in our hospital were investigated,analyzed,and summarized their characteristics.Results The incidence of neonatal infection was highest in all cases of neonatal hyperbilirubinemia,accounting for 41.4%.The remaining etiologies were breast milk jaundice,G6PD deficiency,neonatal ABO hemolysis,scalp hematoma,etc.Cases in neonatal infection,neonatal infection+G6PD deficiency,neonatal infection+neonatal ABO hemolysis,and neonatal infection+scalp hematoma were presented with early onset,rapid progression,and severity.For G6PD deficiency and neonatal ABO hemolysis,the cases were featured by early onset and rapid progression.For scalp hematoma,the cases were characterized by long duration.For other groups of cases,they were featured by long duration and severity.Conclusion A-mong 355 cases of neonatal hyperbilirubinemia,the most common primary disease is neonatal infection in clinic.Differences are presented in the characteristics of hyperbilirubinemia cases caused by various primary diseases. 2018 Vol. 25 (13): 108-110转113 [Abstract] ( 122 ) HTML (35 KB)  PDF  (0 KB)  ( 33 ) 111 Clinical effect analysis of laparoscopic multiple myomectomy LIU Kan ；BAO Meng-xin Objective To investigate the clinical efficacy of laparoscopic multiple myomectomy.Methods From January 2013 to December 2015 in our hospital gynecological examination and treatment of 200 patients with multiple uterine fibroids as the observation object,using random number table method was divided into the control group and the experimental group,100 cases in each group.The control group was treated by conventional open surgery,while the experimental group was treated by laparoscopic myomectomy.The clinical efficacy of the two groups was compared.Results The operation time,anal exhaust time,bed time and hospitalization time in the experimental group were significantly shorter than those in the control group,the amount of bleeding in the books was less than that in the control group,and the postoperative analgesic drug utilization rate was lower than that in the control group,the differences were statistically significant(P＜0.05).The recurrence rate at 12,24 months after operation,and the incidence of postoperative complications such as poor wound healing and pelvic infection in the experimental group were significantly lower than those in the control group(P＜0.05).Conclusion Patients with multiple myoma of uterus undergone laparoscopic myomectomy is helpful to reduce the recurrence rate and the incidence of complications in a favorable effect and quick postoperative recovery. 2018 Vol. 25 (13): 111-113 [Abstract] ( 137 ) HTML (31 KB)  PDF  (0 KB)  ( 24 ) 114 Observation of the clinical effect of early nursing interventions of intestinal probiotics in infants with eczema LU Xiu-yi Objective To study the clinical application value of early nursing interventions of intestinal probiotics in infants with eczema.Methods A total of 60 children with eczema treated in our hospital from January to June in 2016 were selected as the research object and were divided into the study group and the control group with 30 cases in each group by random number table method.The study group was treated with intestinal probiotics,while the control group was treated with routine therapy.The therapeutic effects of the two groups were compared.Result The disappearance time of symptoms in the study group was lower than that in the control group,the difference was statistically significant(P＜0.05).The total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).The recurrence rate of the study group was significantly lower than that of the control group,the difference was statistically significant(P＜0.05).Conclusion The early nursing interventions of intestinal probiotics can improve the clinical effect,promote their fast recovery,reduce the recurrence rate and increase the clinical safety. 2018 Vol. 25 (13): 114-116 [Abstract] ( 141 ) HTML (33 KB)  PDF  (0 KB)  ( 26 ) 117 The effect of hysteroscopy combined with laparoscopy in the treatment of tubal infertility LI Kai-yan；SHEN Hui-min Objective To explore the effect of hysteroscopy combined with laparoscopy in the treatment of tubal infertility.Methods From January 2015 to December 2016,189 patients with tubal infertility were selected from People′s Hospital of Chao an District of Chaozhou City in Guangdong Province,and the First Affiliated Hospital of Sun Yat-sen University,the patients were divided into laparoscopic group(n=94)and hysteroscopy group(n=95)according to the order of treatment.The patients in laparoscopic group were treated by laparoscopy alone,and the patients in hysteroscopy group were treated by hysteroscopy combined with laparoscopy.After 1 year follow-up,the operation time,intraoperative blood loss,tubal patency rate and pregnancy rate were compared between the two groups.Results The operation time in laparoscopic group was significantly longer than that in laparoscopic group,but the bleeding volume in laparoscopic group was significantly lower than that in laparoscopic group,the difference was statistically siginificant(P＜0.05).There was no significant difference in PaCO2and SaO2between the two groups(P＞0.05).The dredging rate of hysteroscopy group was significantly higher than that of laparoscopy group,the difference was statistically siginificant(P＜0.05).The pregnancy rate of 6,12 months in laparoscopy group was significantly higher than that in laparoscopy group,the difference was statistically siginificant(P＜0.05).There was no significant difference between the two groups(χ2=0.7098,P＞0.05).Conclusion Hysteroscopy combined with laparoscopy has good clinical effect in the treatment of tubal infertility.It is safe and reliable.Postoperative tubal dredging rate and pregnancy rate are high,which is worthy of clinical application. 2018 Vol. 25 (13): 117-119 [Abstract] ( 119 ) HTML (35 KB)  PDF  (0 KB)  ( 35 ) 120 The effect analysis of ozone combined with nifuratel and nystatin vaginal ointment in the treatment of kysthitis MO Qiu；LI Hui；LIN Xiao-lan Objective To approach result of treatment kysthitis by ozone combined with nifuratel and nystatin vaginal ointment.Methods The clinical data of 100 patients with vaginitis treated in our hospital from March 2016 to March 2017 were analyzed.The patients were divided into two groups according to different treatment methods：the control group(treated with nifuratel vaginal soft capsule alone)and the observation group(treated with ozone combined with nifuratel vaginal soft capsule),50 caes in each group.The clinical symptom scores,1,2,3 d clinical symptom remission rates and clinical efficacy were compared between the two groups.Results There was no significant difference in clinical symptom scores between the two groups(P＞0.05).After treatment,the clinical symptom scores of the two groups were lower than those before treatment,and the clinical symptom scores of the observation group were lower than those of the control group(P＜0.05).The remission rate of clinical symptoms in the observation group was higher than that in the control group at 1,2 and 3 days after treatment(P＜0.05).The total effective rate of the observation group was higher than that of the control group(P＜0.05).Conclusion The treatment kysthitis patients by ozone combined with nifuratel and nystatin vaginal ointment,linical symptoms and response duration is good,the result is idea,it is worth to be used. 2018 Vol. 25 (13): 120-122 [Abstract] ( 122 ) HTML (33 KB)  PDF  (0 KB)  ( 29 ) 123 129 cases of cesarean section for caesarean scar pregnancy under Ultrasound guided LI Yun-hui；DAI Hong-ying； LI Wei-wei；NIU Zhao-guo；YANG Meng-meng Objective To evaluate the safety feasibility and influence factors of curettage for caesarean scar pregnancy under Ultrasound guided.Methods The clinical data of 129 patients with CSP who underwent ultrasound-guided curettage in affiliated hospital of Qingdao university from January 2014 to May 2017 were analyzed retrospectively.According to the observation index and evaluation criteria,the patients were divided into two groups：success group(n=118)and failure group(n=11).The gestational weeks,gestational sac size,preoperative blood β-HCG,myometrial thickness of uterine anterior wall at focus,intraoperative blood loss and treatment methods after curettage failure were compared between the two groups.Results There was no significant difference in pregnancy age,gestational sac size and preoperative blood β-HCG between the two groups(P＞0.05).In the successful group,the time of menopause was shorter than that in the failed group,the thickness of myometrium in the lesion was better than that in the failed group,and the amount of intraoperative bleeding was less than that in the failed group,the difference was statistically significant(P＜0.05).Of the 11 failed cases,5 underwent cesarean scar pregnancy tissue removal.5 cases were successfully treated with mifepristone.One patient underwent cesarean scar pregnancy tissue removal after embolization due to massive hemorrhage during hysterectomy.Conclusion When CSP gestational age＜7 weeks,thickness of muscle layer≥4.0 mm,underwent ultrasound guided curettage with high security.For the failed CSP of curettage,if the local blood flow signal is rich,the surgical treatment should be performed.If the local blood flow signal is not rich,the conservative treatment should be performed. 2018 Vol. 25 (13): 123-125 [Abstract] ( 135 ) HTML (34 KB)  PDF  (0 KB)  ( 25 ) 126 Application of micro-heparin sodium combined with total nutrient admixture continuous infusion in safeguard after peripherally inserted central catheter GUO Juan； WEI Ting ；CAO Juan ；PENG Li-yuan ；LONG Xiao-hong Objective To discuss the effect of micro-heparin sodium combined with total nutrient admixture in preventing catheter occlusion after PICC.Methods From 2016 to June 2017,84 neonates with PICC catheter were selected as the research object.All the newborns were randomly divided into control group and observation group,42 cases in each group.Two groups of newborns were given intravenous infusion of nutrient solution,the observation group of newborns on the basis of each ml of nutrient solution added 0.5 U heparin sodium for continuous intravenous drip.The incidence of catheter occlusion,bacterial colonization and catheter-related bloodstream infection were compared between the two groups.prothrombin time（PT）,activated partial prothrombin time（APTT）,thrombin time（TT）and platelet count（PLT）were measured to evaluate the safety of heparin sodium compatibility.Results The incidence of catheter blockage,bacterial colonization and catheter-related bloodstream infection in the observation group were significantly lower than those in the control group （P＜0.05）.There was no significant difference in coagulation function between the two groups （P＞0.05）.Conclusion The compatibility of trace heparin sodium combined with total nutrient admixture continuous intravenous infusion can effectively reduce the neonatal PICC catheter tube blockage,bacterial colonization and catheter-related bloodstream infection,while not on the coagulation function in the neonates is safe and reliable. 2018 Vol. 25 (13): 126-128转140 [Abstract] ( 128 ) HTML (36 KB)  PDF  (0 KB)  ( 29 ) 129 Clinical value comparaison of CT and MRI in preoperative diagnosis of invasive cervical cancer CHENG Liang；YANG De-wen； XU Chang；LIU Yang；YU Wen-long Objective To compare and analyze the clinical value of two imaging techniques of CT and MRI in preoperative diagnosis of invasive cervical cancer.Methods A total of 76 patients with invasive cervical cancer who were confirmed by pathological examination after operation in our hospital from September 2015 to September 2017 were selected and divided into the control group and the study group according to their different inspection methods before operation,there were 38 cases in each group.The control group received CT examination before operation,and the study group received MRI examination before operation.The imaging diagnosis operation time,preoperative dispute diagnosis,coincidence rate of preoperative diagnosis and postoperative pathological examination,misdiagnosis and missed diagnosis were compared between the two groups.ResultsThe disputes caused preoperative diagnosis in the study group was only 1 cases(2.6%),which was less than 8 cases(21.1%)in the control group,with significant difference(P＜0.05).The coincidence rate of cervical cancer preoperative diagnosis and postoperative pathological examination results in the study group was 94.7%,which was higher than 63.2%in the control group,with significant difference(P＜0.05).The rate of misdiagnosis and missed diagnosis in the study group were less than that in the control group,with significant difference(P＜0.05).There was no significant difference in the time of imaging diagnosis between the two groups(P＞0.05).Conclusion Invasive cervical cancer patients who were diagnosed by MRI before surgery,although the operation time will be extended to a certain extent,but its accuracy is higher,which can effectively reduce the misdiagnosis and missed diagnosis cases,the disputes caused by disease diagnosis can be controlled,so that more effective treatment time can be obtained for patients. 2018 Vol. 25 (13): 129-131 [Abstract] ( 129 ) HTML (32 KB)  PDF  (0 KB)  ( 29 ) 132 Value of CT angiography in the diagnosis of acute pulmonary embolism in emergency department DONG Zhi-hui；WEN Xue-hui；MIAO Yan-rong；QIAO Ting Objective To investigate the effect of CT angiography in the diagnosis of acute pulmonary embolism in emergency department.Methods The clinical data of 20 suspected pulmonary embolism patients admitted to Emergency Department of Hongqi Hospital Affiliated to Mudanjiang Medical University from January 2016 to December 2017 were retrospectively analyzed.All patients underwent CT examination,and the diagnostic effect of CT imaging was analyzed.Results The sensitivity of CT angiography was 94.44%,the detection rate was 94.44%,and the diagnostic coincidence rate was 90.00%.CT images of the diagnosis could clearly show the pulmonary artery embolism position and embolus morphology.Conclusion CT angiography has a high coincidence rate in the diagnosis of acute pulmonary embolism.CT angiography can clearly show the embolic position and embolus morphology of patients with acute pulmonary embolism.It has obvious diagnostic advantage and clinical value for pulmonary embolism diagnosis. 2018 Vol. 25 (13): 132-134 [Abstract] ( 130 ) HTML (34 KB)  PDF  (0 KB)  ( 34 ) 135 Analysis on the effect of Metformin on reducing the incidence rate of Alzheimer′s disease in the patients with type 2 diabetes mellitus XU Xiao-ling Objective To explore the effect of Metformin on reducing the incidence rate of Alzheimer′s disease(AD)in the patients with type 2 diabetes mellitus.Methods A total of 90 patients with type 2 diabetes mellitus who were admitted to our hospital from January to December in 2017,were selected as the research subjects,and were randomly divided into observation group and control group according to the random number table,45 patients in each group.The observation group were given Metformin,and patients in the control group were given Acarbose Tablets for treatment.The effect of different treatment methods on the therapeutic effect,insulin resistance (HOMA-IR),AD,and incidence rate of adverse reactions were compared between the two groups of patients.Results The observation group was significantly lower than that in the control group in terms of fasting plasma glucose(FBG),2 h postprandial blood glucose(2 h PG),fasting insulin(FINs),glycosylated hemoglobin(HbA1c),peripheral blood leukocyte,body mass index(BMI)(P＜0.05).The blood vitamin B12and connecting peptide(C peptide)were significantly higher than that in the control group(P＜0.05).The observation group was significantly lower than that in the control group in terms of HOMA-IR(P＜0.05).The incidence rate of AD and adverse reactions was significantly lower than that in the control group,the differences were statistically significant(P＜0.05).Conclusion When Metformin is used in the patients with type 2 diabetes,it can not only reduce HOMA-IR and the incidence rate of AD，it can also improve the patient-related indicators,maintain blood sugar stability,and the incidence rate of adverse reactions is less.This method is worthy of application and promotion. 2018 Vol. 25 (13): 135-137 [Abstract] ( 133 ) HTML (32 KB)  PDF  (0 KB)  ( 22 ) 138 Effects of tea oil combined with Montmorillonite Powder and Vitamin C in the treatment of oral ulcer induced by paraquat poisoning QIU Hong；HUANG Ying-lan；ZENG Wei-lan；LIU Xiang-hong；ZHONG Zhen-zhou Objective To observe and evaluate the efficacy of tea oil combined with Montmorillonite Powder and Vitamin C in the treatment of oral ulcer induced by paraquat poisoning,so as to provide a safe,effective and satisfactory oral care method for patients orally taking PQ.Methods A total of 40 patients with acute paraquat poisoning who were hospitalized in our department from January 2014 to December 2017 were collected.In accordance with the principle of randomized control,they were divided into experimental group and control group,20 cases in each group.Patients in the control group were routinely given Qingkou mouth rinses every morning and evening to maintain oral hygiene.In the experimental group,on the basis of the control group,10 to 20 ml of tea oil combined with 5 g of Montmorillonite Powder puls 5 g of Vitamin C were ground into powder,mixed into a paste to apply on local ulcer and cover the ulcer surface,3 times per day.Water and food should be avoided after 30 minutes of medication.The course of treatment for observation was 5 days.The therapeutic effects were observed and the safety was analyzed in both groups.Results There was no significant difference in the severity and time of oral ulcer between the two groups(P＞0.05).The difference was not statistically significant.The pain relief time and healing time of oral ulcer in the experimental group were significantly shorter than those in the control group,and the differences were statistically significant(P＜0.01).Conclusion The efficacy of tea oil combined with Montmorillonite Powder and Vitamin C in the treatment of oral ulcer induced by paraquat poisoning is significant,which alleviates the physical and mental pain of hospitalized patients with PQ,reduces the occurrence of complications,and meanwhile improves the quality of life of patients.It is worthy of promotion. 2018 Vol. 25 (13): 138-140 [Abstract] ( 154 ) HTML (33 KB)  PDF  (0 KB)  ( 23 ) 141 Clinical study of Kuntai Capsules combined with Dydrogesterone in the treatment of climacteric syndrome with anxiety and depression KANG You-hong；ZHOU Hong Objective To analyze the clinical efficacy of Kuntai Capsules combined with Dydrogesterone in the treatment of climacteric syndrome with anxiety and depression.Methods By a random number table,80 menopausal syndrome patients with anxiety and depression treated in our hospital from March 2015 to June 2016 were divided into control group and observation group.The control group was treated with Dydrogesterone and the observation group was treated Kuntai Capsules combined with Dydrogesterone respectively.The clinical therapeutic effect in the two groups were observed and compared.Results There was no significant difference in Kupperman(K)score,Hamilton Anxiety Rating Scale(HAMA)score or Hamilton Depression Scale(HAMD)score before treatment between the two groups(P＞0.05).After treatment,the K score was significantly higher in the observation group(P＜0.05).With regard to total effectiveness rate,the rate in the observation group was significantly higher compared with that in the control group(P＜0.05).After therapy,the HAMA and HAMD scores decreased significantly in the observation group in comparison with those in the control group,the differences were statistically significant(P＜0.05).Conclusion The combination of Kuntai Capsules and dydrogesterone for menopausal syndrome with anxiety and depression has a remarkable clinical effect on increasing K score,decreas HAMA and HAMD scores. 2018 Vol. 25 (13): 141-143 [Abstract] ( 192 ) HTML (33 KB)  PDF  (0 KB)  ( 35 ) 144 Efficacy of Tripterygium Wilfordii Multi Glucoside combined with hormone and ARB drugs in the treatment of lupus nephritis LIU Fang ；ZENG Hui-fen； MIAO Hui；LIU Xi；SHEN Ming-jing Objective To investigate the efficacy of Tripterygium Wilfordii Multi Glucoside combined with hormone and ARB drugs in the treatment of lupus nephritis.Methods From January 2016 to December 2017,a total of 62 patients with lupus nephritis were selected as the study object.They were divided into the experimental group(31 cases)and the routine group(31 cases)by the random number table method.The routine group was treated with hormone and ARB drugs only,and the experimental group was treated with Tripterygium Wilfordii Multi Glucoside Tablets on the basis of routine group.The treatment effect，the biochemical index after treatment and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate in the experimental group was higher than that in the routine group,the difference was of statistically significant(P＜0.05).The C3,C4 and ALB in experimental group was significantly higher than that in the control group,Cr,urinary protein,SLEDAI score was significantly lower than that in the routine group,the differences were statistically significant(P＜0.05).The adverse reactions rate in the experimental group compared with the routine group,the difference was no statistically significant(P＞0.05).Conclusion Tripterygium Glycosides Tablets combined with hormone and ARB drugs are effective in the treatment of lupus nephritis,it is a safe,effective treatment method,and is worthy of popularization.   2018 Vol. 25 (13): 144-146转150 [Abstract] ( 135 ) HTML (36 KB)  PDF  (0 KB)  ( 27 ) 147 Controlled study on Bupropion Sustained-Release Tablets and Paroxetine in the treatment of depression induced by Parkinson′s disease LIAN Peng；SUN Meng-meng；FENG Lin；FENG Xiao-li；ZHANG Can-wen Objective To compare the efficacy of Bupropion Sustained-Release Tablets and Paroxetine in improving depression and quality of life in the patients with Parkinson′s disease.Methods From February 2016 to September 2017,42 patients with Parkinson′s disease complicated with depression who were were admitted to the outpatient and inpatient in Tai′an Psychiatric Hospital were selected.The random number table was used to divide them into study group and control group,21 patients in each group.The study group was given Bupropion Sustained-Release Tablets for treatment,and the control group was given Paroxetine for treatment.The course of treatment was 6 weeks.The degree of depression changes was assessed by the Hamilton Depression Scale(HAMD).The third subscale of the comprehensive Parkinson′s disease rating Scale(UPDRS)was used to assess motor function.39-item Parkinson′s disease questionnaire(PDQ-39)scores were used to assess the changes in quality of life.Results Before treatment,the scores of HAMD,UPDRS,and PDQ-39 in the two groups of patients were compared,and the differences were not statistically significant(P＞0.05).After 2,4,and 6 weeks of treatment,the HAMD scores in both groups were significantly lower than those before treatment,and the differences were statistically significant(P＜0.01).There was no statistically significant difference in HAMD scores between the two groups(P＞0.05);the third subscale of UPDRS and PDQ-39 score in the study group at 2,4 and 6 weeks were significantly lower than those before treatment(P＜0.01).There was no statistically significant difference in the control group compared with that before treatment(P＞0.05).Conclusion Bupropion Sustained-Release Tablets can not only improve the depression of the patients with Parkinson′s disease,but also improve the motor symptoms and quality of life in the patients with Parkinson′s disease and depression,which is worthy of promotion. 2018 Vol. 25 (13): 147-150 [Abstract] ( 142 ) HTML (39 KB)  PDF  (0 KB)  ( 34 ) 151 Comparison effect of Febuxostat and Allopurinol in the treatment of patients with gout accompanied with renal insufficiency LI Xiao-ying ；HUANG Hui；YANG Dan-dan； HUANG Jun-qiao ；ZHAO Xiao-yue ；ZHU Zheng-xi Objective To investigate the effect comparison of Febuxostat and Allopurinol in the treatment of patients with gout and renal insufficiency.Methods From April 2016 to April 2017，100 patients with gout and renal insufficiency who were willing to joint in this study admitted to our hospital were selected as research subjects.They were divided into research group and control group according to the visiting time.In the control group，patients were treated with Allopurinol，and in the research group，participants were provided with Febuxostat.The levels of serum urnic acid and liver and kidney function before and after treatment，and the occurrence of adverse reactions during the treatment were compared in the two groups.Results There was no significant difference in serum urnic acid levels or liver and kidney function levels between the two groups before treatment （P＞0.05）.Both unic acid levels and liver and kidney function levels were improved after treatment.The blood urnic acid levels in the research group were lower than those in the control group，the differences were statistically significant（P＜0.05），but there was no great difference in the indicators of liver and kidney functions was displayed between the control group and research group （P＞0.05）.With regard to the incidence of adverse reactions between the two groups，the difference was not significant （P＞0.05）.Conclusion The efficacy of Febuxostat in the treatment of patients with gout and renal insufficiency is higher compared with that of Allopurinol in higher safety. 2018 Vol. 25 (13): 151-153 [Abstract] ( 145 ) HTML (32 KB)  PDF  (0 KB)  ( 42 ) 154 Effect comparison of Mesalazine and Salazosulfapyridine in the treatment of ulcerative colitis GONG Long-hui；LAI Jin-mao； WU Kun-feng；WANG Jing Objective To analyze the efficacy of Mesalazine and Salazosulfapyridine in the treatment of ulcerative colitis.Methods The subjects of this study were all selected from 120 patients with ulcerative colitis treated in our hospital from August 2016 to August 2017.By a random number table,they were evenly divided into control group and experimental group,60 cases in each group.Patients in the control group were treated with Salazosulfapyridine,while in the experimental group,Mesalazine was adopted.The total treatment effectiveness rate and the scores of histological examinations before and after treatment were compared between the two groups.In addition,the occurrence of adverse reactions in the two groups was observed.Results After treatment,in the experimental group,the total effectiveness rates for diarrhea,abdominal pain,and mucus bloody stool were 95.00%,96.67%,and 93.33%,which was significantly higher than those of the control group,with statistical significance(P＜0.05).Before treatment,the difference in histological examination scores was not significant(P＞0.05).After treatment,histological examination score in the experimental group was(0.81±0.41)points,which was superior to that before treatment and the control group,with statistical significance(P＜0.05).The incidence of adverse reactions in the experimental group was 8.33%,which was significantly lower than that in the control group accounting for 21.67%(P＜0.05).Conclusion For patients with ulcerative colitis,the efficacy of Mesalazine is better compared with Salazosulfapyridine.The former can improve clinical symptoms,reduce adverse reactions in high safety,which is worth recommending in future clinical practice. 2018 Vol. 25 (13): 154-156 [Abstract] ( 142 ) HTML (33 KB)  PDF  (0 KB)  ( 33 ) 157 Efficacy of Edaravone combined with Clopidogrel in the treatment of acute cerebral infarction JIANG Dong-bo ；LI Man-lian Objective To explore the effect of Edaravone combined with Clopidogrel in the treatment of acute cerebral infarction.Methods By random number table method,48 patients with acute cerebral infarction treated in our hospital from August 2015 to August 2017 were divided into the control group and the experimental group,24 cases in each group.The control group was treated with Clopidogrel alone,and the experimental group was treated with Edaravone combined with Clopidogrel.The total effective rate,neurological deficit(NHISS)score，activities of daily living(Barthel)score and adverse reactions were compared between the two groups before and after treatment.ResultsThe total effective rate of the experimental group was 95.83%,which was significantly higher than that of the control group (P＜0.05).After the treatment,the score of neurological deficit and the activity score of daily living in the two groups were significantly different.The NHISS scores and Barthel scores of the experimental groups were better than those of the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion For patients with acute cerebral infarction,Edaravone combined with Clopidogrel treatment effect is significant,can improve the neurological function defect score,worthy of promotion and application in the future. 2018 Vol. 25 (13): 157-159 [Abstract] ( 96 ) HTML (34 KB)  PDF  (0 KB)  ( 40 ) 160 Clinical efficacy of Azithromycin in the treatment of Mycoplasma pneumonia in children OU Qi Objective To investigate clinical efficacy of Azithromycin in the treatment of 31 cases of Mycoplasma pneumonia in children.Methods A total of 62 children with Mycoplasma pneumonia were collected from June 2014 to June 2017 in our hospital and were randomly divided into control group(n=31)and observation group(n=31).The two groups were given symptomatic treatment.On the basis of treatment,the control group was treated with Erythromycin,while the observation group was treated with Azithromycin.The therapeutic effects of the two groups were compared.Results①The fever time,cough time and rale time in the observation group were shorter than those in the control group(P＜0.05).②The total effective rate of the observation group was 94.5%,which was significantly higher than 70.9%of the control group(P＜0.05).③The adverse reaction rate of the observation group was 12.9%,which was significantly lower than 35.4%of the control group,the differences were statistically significant(P＜0.05).Conclusion In the treatment of children with Mycoplasma pneumonia,Azithromycin can effectively improve the patient′s clinical symptoms and signs,treatment effect is good,and adverse reaction is less.It is an ideal treatment drug. 2018 Vol. 25 (13): 160-162 [Abstract] ( 120 ) HTML (31 KB)  PDF  (0 KB)  ( 33 ) 163 The clinical effect of Magnesium Valproate Sustained Release Tablets combined with Olanzapine in the treatment of Alzheimer′s disease LIN Cai-yun； CAI Qi-jian ；LU Yi Objective To investigate the clinical effect of Magnesium Valproate Sustained Release Tablets combined with Olanzapine in the treatment of Alzheimer′s disease.Methods A total of 80 patients in our hospital from October 2015 to October 2017 were selected and divided into the treatment group and the control group by stratified sampling,40 cases in each group.The patients in the treatment group were treated with Magnesium Valproate Sustained Release Tablets and Olanzapine,while the control group was treated with Olanzapine only.After four weeks of treatment,the behavior and consciousness were evaluated by BRMS,and the SF-36 scale evaluated the quality of life.The difference between the manic state and the quality of life in the two groups was analyzed.Results After 4 weeks of treatment,the treatment group of patients with mania was significantly lower than that of the control group(P＜0.05)，quality of life include physical function in treatment group patients,social function,activity,psychological function was significantly higher than that in the control group,the differences were statistically significant(P＜0.05).Conclusion Magnesium Valproate Sustained Release Tablets combined with Olanzapine are able to control the behavioral and psychological symptoms of Alzheimer′s disease more quickly and effectively.It is suggested that to be promoted in clinical work. 2018 Vol. 25 (13): 163-165 [Abstract] ( 129 ) HTML (33 KB)  PDF  (0 KB)  ( 30 ) 166 Clinical study on the relationships between TCM constitution and TCM syndrome of patients with recurrent mouth ulcers DENG Yun Objective To investigate the relationships between TCM constitutional types and TCM syndrome of patients with recurrent mouth ulcers (ROU).Methods Questionnaire was designed according to Chinese medicine clinical research of new drugs guiding principles and Classification and determination of TCM constitution.From July 1st,2016 to June 30th,2017,150 patients with ROU were included in and were given questionnaire investigation.Results Among 150 cases,15 cases(10.00%)were normal constitution and 135 cases(90.00%)were biased constitution.The first four types of biased constitution were damp-heat constitution(44 cases,29.33%),yang deficiency constitution(30 cases,20.00%),yin deficiency constitution(18 cases,12.00%),and phlegm-dampness constitution(17 cases,11.30%).31.81%of patients with damp-heat constitution got flaring-up of stomach fire syndrome,while 45.45%of them got accumulated heat in heart and spleen syndrome.50.00%of patients with yang deficiency constitution got syndrome of spleen-kidney yang deficiency.Among those with yin deficiency constitution,33.33%got syndrome of fire excess from yin deficiency and 33.33%got syndrome of dampness stagnancy due to spleen deficiency.35.29%of those with phlegm-dampness constitution were with syndrome of dampness stagnancy due to spleen deficiency at time.Conclusion People with damp-heat constitution,yang deficiency constitution,yin deficiency constitution,and phlegm-dampness constitution are more likely to get ROU.Patients of ROU with different constitutions may get different syndromes,so,in the treatment of ROU,the type of patients′constitution should be paid attention to and understand the law of its development by grasping the constitution,and it is necessary to apply the syndrome differentiation and treatment on the basis of the constitution identification;in the prevention,it is expected that through physical identification,it is possible to guide the people with ROU who have the physique to adopt appropriate methods of care,so as to improve the bias constitution and prevent the occurrence and development of ROU. 2018 Vol. 25 (13): 166-169 [Abstract] ( 132 ) HTML (40 KB)  PDF  (0 KB)  ( 30 ) 170 Clinical observation of acupuncture combined with Dispelling wind activating collaterals empirical decoction for oral administration and fuming and washing dialectically treating acute peripheral paralysis LIU Xiao Objective To explore the clinical effect of acupuncture combined with Dispelling wind activating collaterals empirical decoction for oral administration and fuming and washing dialectically treating acute peripheral paralysis.Methods All of 40 patients with acute peripheral paralysis treated in our hospital from February 2013 to March 2017 were selected as objects and they were divided into the control group(n=70)and observation group(n=70).The control group was given conventional therapy while the observation group was given acupuncture combined with Dispelling wind activating collaterals empirical decoction for oral administration and fuming and washing treatment.The electromyographic findings,facial nerve functional classification and clinical efficacy in patients between the two groups were compared.Results There was no significant difference in amplitude and latency between the two groups before treatment(P＞0.05).The amplitude of the two groups after treatment was higher than that before treatment and the latent period was shorter than that before the treatment,the amplitude of the patients in the observation group was higher than that of the control group,and the latent period was shorter than the control group,and the facial nerve function grade was superior to the control group,the total effective rate was higher than that of the control group,and the differences were statistically significant(P＜0.05).Conclusion For acupuncture combined with Dispelling wind activating collaterals empirical decoction for oral administration and fuming and washing dialectically treating acute peripheral paralysis,the improvement of nerve function is good and the effect is obvious.It is worthy of clinical promotion and application. 2018 Vol. 25 (13): 170-172 [Abstract] ( 119 ) HTML (33 KB)  PDF  (0 KB)  ( 30 ) 173 Survey of antipsychotic drug use status in second-class hospital and analysis of its influence factor ZHU Jian； SHI Zhan-ming ；WEN Hong-xia ；SUN Meng； SHEN Yan ；LIU Jia-sheng； CHEN Deng-guo；HUANG Cai-hong Objective To explore the antipsychotic drug use status in second-class hospital and its influence factor.Methods A total of 315 patients with schizophrenia were diagnosed with ICD-10 criteria who admitted to the mental healthy center in Jiangbei district of Chongqing were selected as subjects.A cross-sectional survey assessed by the self-compiled questionnaire.Results Of the 315 hospitalized patients,163(51.7%)used single drug and 152(48.3%)used drug combination.The second-generation antipsychotic drugs were dominant in mono-therapy(158 cases,50.2%),double second-generation antipsychotic drugs were dominant in poly-therapy(123 cases,39.0%).In the second generation antipsychotics,the frequency of drug use in the top three were Risperidone(47.30%),Clozapine(31.11%)and Aripiprazole(30.16%).The gender of patients in different medications groups was statistically significant(P＜0.05).The total duration of patients in the combined drug group was significantly longer than that of the single drug group,and the difference was statistically significant(P＜0.01).Logistic regression analysis showed that the course was the risk factor of drug combination(β=0.047,OR=0.047,95%CI=1.021-1.077,P＜0.01),longer disease duration was more inclined to choose drug combination,the age was the protection factor for drug selection(β=0.029,OR=0.029,95%CI=0949-0.994,P＜0.05),older patients was more inclined to choose single drug therapy.Conclusion At present,second-class hospitals are mainly treated with second-generation antipsychotics drugs,and single and combination drugs together play a role in the treatment of schizophrenia. 2018 Vol. 25 (13): 173-176 [Abstract] ( 131 ) HTML (37 KB)  PDF  (0 KB)  ( 25 ) 177 Intervention effects of new central venous catheter pocket nursing in patients with hemodialysis catheter ZHANG Jian-ying； CHEN Fu-sheng ；LUO Xue-qin Objective To explore the effect of pocket nursing intervention of new central venous catheter(CVC)on patients with maintenance hemodialysis(MHD)catheter.Methods A total of 64 patients who underwent HD and CVC in our hospital from December 2013 to June 2017 were selected as the subjects,and they were divided into observation group (n=32)and control group (n=32)by the random number table method.The control group was given routine CVC nursing,while the observation group was given self-made pocket nursing intervention.The satisfaction and complications(infection,catheter displacement,blood seepage)of the two groups of patients after 1 month of intervention were recorded.The pain degree(numerical rating scale[NRS])and quality of life(kidney diseasequestionnaire[KDQ])before intervention and after 1 month of intervention were compared between the two groups.Results After 1 month of intervention,the total nursing satisfaction of observation group was significantly higher than that of the control group the,and the difference was statistically significant(P＜0.05).After 1 month of intervention,the NRS scores of the two groups were lower than before intervention,while the KDQ scores were higher than before intervention,the differences were statistically significant(P＜0.05).The NRS score of patients in the observation group was lower than that in the control group,and KDQ score was higher than the control group,the differences were statistically significant(P＜0.05).During the intervention,the total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion The new pocket nursing intervention can improve the quality of life of patients undergoing MHD and CVC,and it also can reduce the pain degree and the incidence of complications,which is of positive significance for improving the nursing quality and nursing satisfaction. 2018 Vol. 25 (13): 177-179转193 [Abstract] ( 130 ) HTML (37 KB)  PDF  (0 KB)  ( 34 ) 180 Clinical application effect of personalized nursing in children with hypoxic-ischemic encephalopathy YANG Qiu-rong ；LIN Shi-shun ；ZHONG Li-ya Objective To explore the clinical effect of personalized nursing intervention in children with hypoxic-ischemic encephalopathy.Methods Eighty-eight children with hypoxic-ischemic encephalopathy admitted to department of neonatology in our hospital from August 2014 to August 2017 were selected as subjects.They were evenly divided into observation group and control group according to the random number table method.The children in the control group were treated with neonatal disease routine nursing mode,while children in the observation group were treated with personalized nursing model.The therapeutic effect,incidence of adverse events and patient′s families satisfaction were observed and compared in the two groups.Results The total therapeutic effectiveness rate in the observation group was 90.9%,which was higher than that of the control group accounting for 70.5%,the difference was statistically significant(P＜0.05).In the observation group,the nursing satisfaction of patient′s families was 95.5%,which was higher than that in the control group accounting for 79.5%,the difference was statistically significant(P＜0.05).The incidence of adverse events in the observation group was 2.3%,which was lower than that in the control group of 18.2%,the difference was statistically significant(P＜0.05).Conclusion The implementation of personalized nursing intervention during the treatment in children with hypoxic-ischemic encephalopathy can improve the clinical treatment effect,reduce the occurrence of adverse events,and increase the nursing satisfaction of patient′s families in a remarkable effect,which is worthy of exploration and clinical application. 2018 Vol. 25 (13): 180-183 [Abstract] ( 139 ) HTML (39 KB)  PDF  (0 KB)  ( 31 ) 184 Application effect of targeted nursing intervention in internal arteriovenous fistula blunt needle buttonhole puncture method ZHANG Chun-fen；HONG Xiao-ying Objective To explore the effect of targeted nursing intervention in internal arteriovenous fistulas.Methods A total of 100 cases of arteriovenous fistula and maintenance of hemodialysis treated in our hospital from January to October in 2017 were selected as the study subjects.The 50 patients treated from January to May in 2017 were as control group,who treated with routine nursing.The 50 patients treated from June to October in 2017 were as observation group,who treated with targeted nursing intervention.The success rate of one-time puncture,the rate of complications,the duration of hemostasis and compression,and satisfaction of patients were compared between the two groups.Results The success rate of one-time puncture in the observation group(96.0%)was higher than that in the control group(82.0%),the complication rate in the observation group(2.0%)was lower than that in the control group(14.0%),and the differences were statistically significant(P＜0.05).The duration of hemostasis and compression in the observation group ([10.58±2.14]min)was shorter than that in the control group([11.54±1.76]min),the satisfaction score of the observation group([8.76±1.32]points)was higher than that of the control group([7.90±1.28]points),with a significant differences (P＜0.05).Conclusion Targeted nursing intervention can improve the success rate of one-time puncture with blunt needle buttonhole puncture,shorten the duration of hemostasis and compression,reduce the rate of complications,and improve patient satisfaction.This method is worthy of clinical application. 2018 Vol. 25 (13): 184-186 [Abstract] ( 134 ) HTML (35 KB)  PDF  (0 KB)  ( 25 ) 187 Application value of nursing intervention in patients with hemiplegia after ischemic stroke YANG Gerile Objective To investigate the application value of nursing intervention in patients with hemiplegia after ischemic stroke,and to observe its effects on negative emotion and quality.Methods From September 2015 to July 2017,80 patients with hemiplegia after ischemic stroke treated in our hospital were selected as subjects of this study.The random number table method was used to divide them into two groups,each with 40 cases.In the control group,patients were treated with routine nursing,and patients in the observation group were treated with comprehensive nursing intervention.After 1 months,the recovery of nerve function in the two groups was compared,and the improvement of negative emotion and quality of life in the two groups were also compared.Results After intervention,the FMA score in the observation group was higher than that in the control group,and the NIHSS score was lower than the control group,the differences were statistically significant(P＜0.05).After intervention,the SDS and SAS scores in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After intervention,the physical function,psychological state,social function and emotional function score of the patients in the observation group were all higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Comprehensive nursing intervention has a high application value in patients with hemiplegia after ischemic stroke,which can effectively improve the recovery of limb function,and improve negative emotions and improve the quality of life.It is worthy of promotion. 2018 Vol. 25 (13): 187-190 [Abstract] ( 124 ) HTML (37 KB)  PDF  (0 KB)  ( 26 ) 191 Application effect of nursing intervention in children with autumn diarrhea LING Zhi-juan ；XIAO Zhi-tian ；ZHANG Wen-jiao Objective To investigate the effect of nursing intervention in children with autumn diarrhea.Methods A total of 98 cases of children with autumn diarrhea treated in our hospital from January to December in 2017 were selected as subjects and they were randomly divided into control group and treatment group,49 cases in each group.The patients in the control group were given the conventional treatment,and the patients in the treatment group were treated with nursing intervention based on the control group.The clinical efficacy and clinical symptoms between the two groups were compared.Results After treating of 72 hours,the total effective rate in the observation group(93.88%)was significantly higher than that of the control group(79.59%),the difference was of statistical significance(χ2=4.346,P＜0.05).The antipyretic time and antidiarrheal time,antiemetic time in treatment group were shorter than those in the control group,the differences were of statistically significant(t=5.886,10.090,7.882;P＜0.05).Conclusion The active nursing intervention can effectively improve the clinical symptoms in children with autumn diarrhea,enhance the therapeutic effect and promote recovery. 2018 Vol. 25 (13): 191-193 [Abstract] ( 144 ) HTML (31 KB)  PDF  (0 KB)  ( 22 ) 194 Effect of comprehensive nursing intervention on reducing the incidence of hemodialysis complication in uremic patients DAI Qiu-xia ；QIAN Yin-ling Objective To study the effect of comprehensive nursing intervention in reducing the incidence of hemodialysis complications in uremic patients,to provide a reliable basis for clinical.Methods A total of 128 uremic patients admitted in our hospital from February 2016 to March 2017 were selected as the subjects.According to the random number table method，they were randomly divided into experimental group and reference group,each group of 64 cases.The patients were all given the same drug treatment.In the reference group,the routine nursing measures of hemodialysis were adopted,and the patients in the experimental group adopted comprehensive nursing intervention on the basis of the conventional nursing of the reference group.The two groups of patients were 28 days as one intervention.The incidence of hemodialysis complications and nursing satisfaction were compared between the two groups.Results After 28 days of intervention,the incidence of hemodialysis complication in the experimental group was 25.00%,which was significantly lower than that in the control group(67.19%),the difference was statistically significant(P＜0.05).The satisfaction rate of the patients was 98.44%,which was significantly higher than that of the control group (71.88%),the difference was statistically significant (P＜0.05).Conclusion Comprehensive nursing intervention has significant clinical effect in the hemodialysis of uremic patients,which can not only reduce the incidence of postoperative complications in patients,but also can improve the satisfaction of patients′care.It is worthy to be popularized and used clinically. 2018 Vol. 25 (13): 194-196 [Abstract] ( 126 ) HTML (34 KB)  PDF  (0 KB)  ( 29 )

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