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| Evaluation of the clinical efficacy of sublingual immunotherapy with dermatophagoides farianae drops for allergic rhinitis |
| JIANG Ze-bing FANG Xiao-ming LIN Si-ping |
| Department of ENT,People′s Hospital of Puning City,Guangdong Province,Puning 515300,China |
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Abstract ]Objective To evaluate clinical efficacy of sublingual immunotherapy with dermatophagoides farianae drops for allergic rhinitis of different age groups in Jieyang.Methods A total of 510 cases of allergic rhinitis were selected as the research object in our hospital from January 2016 to October 2016.The patients were divided into 6 groups according to age：preschool group(4-6 years old.36 cases),school age group(7-12 years old,89 cases),adolescent group(13-20 years old,143 cases),adolescence group(21-40 years old,126 cases),midlife group(41-60 years old,68 cases),old age group (more than 60 years old,48 cases).All patients were theapied with sublingual immunotherapy with dermatophagoides farinae drops in a year,and clinlcal symptom score,life quality scores and incidence rate of adverse were contrasted in every group before and after treatment.Results After treatment,clinlcal symptom score was lower than before treatment in 510 cases of patients,and clinical effective rate was 76.5%,and life quality was improved than before treatment(P＜0.05),30 cases(5.9%)occured local adverse reactions,24 cases(4.7%)occured slight whole body adverse reaction,clinlcal symptom score and life quality score with different age signs before treatment were (8.07±1.58)and(12.47±3.17)point,(8.12±1.63)and(12.58±3.09)point,(11±1.56)and(12.39±3.11)point,(8.09±1.60)and(12.60±3.15)point,(8.15±1.65)and (12.51±3.08)point,(8.17±1.59)and (12.49±3.13)point respectively,and after treatment were(4.68±1.59)and (8.47±2.64)point,(4.74±1.63)and(8.51±2.51)point,(4.71±1.67)and (8.49±2.58)point,(4.67±1.52)and(8.62±2.61)point,(4.62±1.55)and(8.53±2.66)point,(4.80±1.64)and(8.59±2.55)point,and clinlcal symptom score and life quality score was statistically difference before treatment than after treatment(P＜0.05).Clinlcal symptom score and life quality score was lower at 6 months after treatment than before treatment(P＜0.05),and which was lower at 12 months after treatment than at 6 months after treatment(P＜0.05).ConclusionSublingual immunotherapy with dermatophagoides farianae drops is an effective and high safety method for the treatment of allergic rhinitis.It is worthy of extensive promotion and application,and equivalent efficacy could be achieved for different age groups.
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| [3] |
陈实，王灵，廖峰，等.舌下含服粉尘螨滴剂治疗学龄前与学龄期儿童过敏性哮喘伴变应性鼻炎的疗效评估[J].中华儿科杂志，2013，51（11）：831-835.
|
| [4] |
陈志凌，钱亚昇，刘素琴，等.舌下含服粉尘螨滴剂治疗儿童变异性鼻炎起效时间和疗效观察[J].中华耳鼻咽喉头颈外科杂志，2015，50（8）：622-626.
|
| [5] |
刘红梅，钟凤茹，熊雪蓉，等.舌下含服粉尘螨滴剂治疗过敏性结膜炎的疗效与安全性评估[J].中华全科医师杂志，2014，13（8）：687-689.
|
| [7] |
江瑾玥，郭树良.成人过敏性鼻炎哮喘综合征的协同诊治研究进展[J].中华肺部疾病杂志（电子版），2012，5（6）：550-554.
|
| [8] |
陈伯亚，龙自铭，黄燕君，等.舌下含服粉尘螨滴剂治疗单一和多重过敏变应性鼻炎患者的临床疗效评估[J].中华耳鼻咽喉头颈外科杂志，2013，48（7）：549-554.
|
| [9] |
李沫民，柳旎，王小阳，等.粉尘螨滴剂治疗儿童螨过敏性鼻炎疗效及对血清IL-4，IL-35水平的影响[J].重庆医学，2016，45（12）：1624-1626.
|
| [10] |
凌云，马桂琴.尹桂茹，等.承德地区粉尘螨滴剂治疗过敏性鼻炎疗效观察与分析[J].国际免疫学杂志，2013，36（6）：491-494.
|
| [11] |
徐静，张宏伟，傅寅，等.舌下含服粉尘螨滴剂治疗变应性鼻炎疗效及安全性评估[J].中国眼耳鼻喉科杂志，2014，14（2）：89-91.
|
| [13] |
崔榕，范敏，袁洛花，等.舌下含服粉尘螨剂治疗变应性鼻炎的疗效观察[J].临床合理用药，2013，6（3）：51-52.
|
| [1] |
麦周生，官树雄，冯锡坚.舌下含服变应原疫苗滴剂治疗尘螨所致变应性鼻炎疗效观察[J].海南医学，2016，27（12）：1819-1821.
|
| [2] |
曾霞，陈实，廖峰，等.粉尘螨滴剂舌下含服治疗儿童变应性哮喘的疗效及其对患儿肺功能的影响[J].海南医学，2016，27（8）：1263-1265.
|
| [6] |
Bousquet J，Heinzerling L，Bachert C，et al.Practical guide to skin prick tests in allergic to aeroallergens[J].Allergy，2012，67（1）：18-24.
|
| [14] |
谭华章.粉尘螨舌下脱敏治疗双螨致敏变应性鼻炎的起效时间及机制讨论[J].临床耳鼻咽喉头颈外科杂志，2014，28（5）：296-299.
|
| [15] |
翁文红，陆冬凌.小儿变应性鼻炎粉尘螨检测与脱敏治疗[J].中国现代医生，2013，51（4）：142-143.
|
|
|
|
