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| Survey of antipsychotic drug use status in second-class hospital and analysis of its influence factor |
| ZHU Jian SHI Zhan-ming WEN Hong-xia SUN Meng SHEN Yan LIU Jia-sheng CHEN Deng-guo▲ HUANG Cai-hong |
| Department of Psychiatry,Mental Healthy Center in Jiangbei District,Chongqing 400025,China |
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Abstract Objective To explore the antipsychotic drug use status in second-class hospital and its influence factor.Methods A total of 315 patients with schizophrenia were diagnosed with ICD-10 criteria who admitted to the mental healthy center in Jiangbei district of Chongqing were selected as subjects.A cross-sectional survey assessed by the self-compiled questionnaire.Results Of the 315 hospitalized patients,163(51.7%)used single drug and 152(48.3%)used drug combination.The second-generation antipsychotic drugs were dominant in mono-therapy(158 cases,50.2%),double second-generation antipsychotic drugs were dominant in poly-therapy(123 cases,39.0%).In the second generation antipsychotics,the frequency of drug use in the top three were Risperidone(47.30%),Clozapine(31.11%)and Aripiprazole(30.16%).The gender of patients in different medications groups was statistically significant(P＜0.05).The total duration of patients in the combined drug group was significantly longer than that of the single drug group,and the difference was statistically significant(P＜0.01).Logistic regression analysis showed that the course was the risk factor of drug combination(β=0.047,OR=0.047,95%CI=1.021-1.077,P＜0.01),longer disease duration was more inclined to choose drug combination,the age was the protection factor for drug selection(β=0.029,OR=0.029,95%CI=0949-0.994,P＜0.05),older patients was more inclined to choose single drug therapy.Conclusion At present,second-class hospitals are mainly treated with second-generation antipsychotics drugs,and single and combination drugs together play a role in the treatment of schizophrenia.
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