美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的效果比较

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Abstract Objective To analyze the efficacy of Mesalazine and Salazosulfapyridine in the treatment of ulcerative colitis.Methods The subjects of this study were all selected from 120 patients with ulcerative colitis treated in our hospital from August 2016 to August 2017.By a random number table,they were evenly divided into control group and experimental group,60 cases in each group.Patients in the control group were treated with Salazosulfapyridine,while in the experimental group,Mesalazine was adopted.The total treatment effectiveness rate and the scores of histological examinations before and after treatment were compared between the two groups.In addition,the occurrence of adverse reactions in the two groups was observed.Results After treatment,in the experimental group,the total effectiveness rates for diarrhea,abdominal pain,and mucus bloody stool were 95.00%,96.67%,and 93.33%,which was significantly higher than those of the control group,with statistical significance(P＜0.05).Before treatment,the difference in histological examination scores was not significant(P＞0.05).After treatment,histological examination score in the experimental group was(0.81±0.41)points,which was superior to that before treatment and the control group,with statistical significance(P＜0.05).The incidence of adverse reactions in the experimental group was 8.33%,which was significantly lower than that in the control group accounting for 21.67%(P＜0.05).Conclusion For patients with ulcerative colitis,the efficacy of Mesalazine is better compared with Salazosulfapyridine.The former can improve clinical symptoms,reduce adverse reactions in high safety,which is worth recommending in future clinical practice.

Key words： Ulcerative colitis Mesalazine Salazosulfapyridine Safety

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	Articles by authors
	GONG Long-hui
	LAI Jin-mao
	WU Kun-feng
	WANG Jing

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GONG Long-hui,LAI Jin-mao,WU Kun-feng, et al. Effect comparison of Mesalazine and Salazosulfapyridine in the treatment of ulcerative colitis[J]. 中国当代医药, 2018, 25(13): 154-156.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I13/154

[1]	周全魁，龚杰.美沙拉嗪和柳氮磺吡啶对溃疡性结肠炎患者肠黏膜中TLR4和NF-κb表达的影响[J].中国现代医学杂志，2015，25（1）：34-36.
[2]	魏永凯，耿福能，赵微，等.美沙拉嗪、柳氮磺胺吡啶对葡聚糖硫酸钠诱导的Balb/c小鼠急性溃疡性结肠炎的治疗和免疫影响[J].中国医院药学杂志，2016，36（14）：1190-1195.
[3]	王爽，郑秀艳，孙文华，等.美沙拉嗪对溃疡性结肠炎患者血清CRP，IL-10及TNF-α水平的影响[J].现代生物医学进展，2017，17（14）：2693-2696.
[4]	黄慧民，黄勤.美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的效果对比研究[J].中国当代医药，2014，21（11）：85-86.
[5]	汪启斌，向玲，梨朝良，等.胶体酒石酸铋联合柳氮磺吡啶治疗溃疡性结肠炎疗效评价[J].山西医药杂志，2016，45（19）：2286-2287.
[6]	丁海荣，王丙信，任清华，等.复方甘草酸苷联合柳氮磺吡啶治疗溃疡性结肠炎的临床研究[J].现代药物与临床，2016，31（3）：367-370.
[7]	李杨麟，喻晓东，苏林，等.美常安联合柳氮磺吡啶治疗溃疡性结肠炎的疗效及对血清TNF-α、IL-6、IL-8水平的影响[J].现代生物医学进展，2016，16（10）：1926-1929.
[8]	Satish Kumar CS，Kondal Reddy K，Reddy AG，et al.Protective effect of Lactobacillus plantarum 21，a probiotic on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats[J].Int Immunopharmacol，2015，25（2）：504-510.
[9]	樊耀敏，薛挥，陈博婷.美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎效果对比[J].实用心脑肺血管病杂志，2016，24（B4）：244.
[10]	膝玉丰.柳氮磺吡啶与奥沙拉嗪治疗溃疡性结肠炎的对比研究[J].中国卫生标准管理，2015，6（13）：160-161.
[11]	孙丹杰.柳氮磺吡啶与美沙拉嗪治疗溃疡性结肠炎的对比研究[J].中国卫生标准管理，2016，7（7）：122-123.
[12]	李文东.美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的对比研究[J].中国卫生标准管理，2016，7（9）：115-116.
[13]	张树惠.美沙拉嗪和柳氮磺吡啶对溃疡性结肠炎患者血清炎性因子表达的影响[J].国际医药卫生导报，2016，22（3）：375-378.
[14]	黎永华，陈嫦.美沙拉嗪联合柳氮磺吡啶治疗溃疡性结肠炎效果观察[J].白求恩医学杂志，2015，13（3）：242-244.
[15]	冬根.美沙拉嗪与柳氮磺吡啶比较治疗溃疡性结肠炎的疗效与安全性研究[J].海峡药学，2015，27（11）：111-112.