不同服药时间对80岁以上高血压患者血压昼夜节律及晨峰现象的影响

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Abstract Objective To investigate the influence of differing administration time on blood pressure circadian rhythm and morning blood pressure surge in hypertension patients over 80 years old.Methods The ambulatory blood pressure monitoring was carried out on patients over 80 years old treated in our hospital from June 2014 to June 2015.The dozing-time of long-acting antihypertensive on patients with non-dipper type blood pressure was adjusted from morning to night,and ambulatory blood pressure monitoring was carried out again after 2 weeks.Results Compared with the morning dozing schedule,taking long-acting anti-hypertention drugs at evening having similar BP lowering effect(P＞0.05).In elderly hypertensive patients,taking anti-hypertensive at evening effectively improve the morning blood pressure surge(P＜0.05)and the control rate of morning peak of blood pressure was 83%.Conclusion In hypertension patients over 80 years old,compared with morning dosing schedule,although the circadian rhythm of blood pressure is not significantly changed,taking long-acting anti-hypertensive drugs at evening have similar BP lowering effect,and effectively control the morning blood pressure surge.

Key words： Hypertension Circadian rhythm Chronotherapy Anti-hypertensive drugs Morning blood pressure surge

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	MA Bo-cong
	ZHAO Ming

Cite this article:

MA Bo-cong,ZHAO Ming. The influence of differing administration time on blood pressure circadian rhythm and morning blood pressure surge in hypertension patients over 80 years old[J]. 中国当代医药, 2018, 25(13): 54-56转60.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I13/54

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