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Quick Search     Adv Search 2018 Vol. 25, No. 11 Published: 2018-04-18   4 Evaluation of the interviewer reliability and copolymerization validity of the development screening test LIU Ye;LI Jia-qiong;XIONG Cai-yun;WANG Yao-zhou;LUO Lin-yin;CUI Yu-xia;ZHOU Hao Objective To analyze the reliability and validity of development screening test(DST)in the evaluation of infant development.Methods Infants and children in 0-6 years old who were treated in Department of Pediatric Rehabilitation of Guizhou Provincial People′s Hospital during the period of April 1,2016 to March 31,2017 were selected as the subject of this research.The DSTs of the subject were evaluated by two highly trained professional evaluators to analyze the reliability of their interviewer.The subjects also participated in the Peabody sports development test,which was used as a gold standard assessment tool to analyze the copolymerization validity of DST.Results A total of 174 children(male 99 cases,56.9%)were included in this study,with an average age of(10.23±9.43)months.The developmental quotient(DQ)score in DST was(67.83±19.63)points,and the mental index(MI)score was(61.94±15.9)points.The DQ and MI scores of girls were all higher than those of boys,with statistically significant difference(P＜0.05).The intra-class correlation coefficient(ICC)value of each dimension of DST was between 0.76-0.89,and the results showed that there was a good correlation between the interviewers′score.The correlation coefficients between gross motor operator(GMQ),fine motion operator(FMQ),total motion operator(TMQ)in Peabody and DQ,MI scores of DST were 0.59 vs.0.57,0.62 vs.0.68,0.63 vs.0.64,respectively.The correlation coefficient of Peabody in gross motor between reflection,posture,mobile score and DQ,MI were 0.42 vs.0.36,0.54 vs.0.50,0.56 vs.0.58;the correlation coefficient of grasping and visual motor integration in fine motor and DQ and MI scores were 0.65 vs.0.70,0.62 vs.0.68;each dimension of DST was best correlated with fine motor in the Peabody and slightly lower correlated with gross motor dimensions.Conclusion DST has good inter-interviewer reliability and copolymerization validity,indicating that the test is a reliable and effective tool for motor development screening in Chinese children. 2018 Vol. 25 (11): 4-7 [Abstract] ( 161 ) HTML (39 KB)  PDF  (0 KB)  ( 28 ) 8 Influence of parathyroidectomy in the cognitive function and quality of life for uremia patients with secondary hyperparathyroidism GUO Huan-kai;YANG Xiao-ran;LIANG Jin-yun;LIU Cai-ling;XU Qing-dong Objective To investigate the influence of total parathyroidectomy combined with autologous transplantation in the cognitive function and quality of life for uremia patients with secondary hyperparathyroidism(SHPT).Methods A total of 58 SHPT patients with uremia who were admitted to our hospital from January 2015 to October 2016 were selected as the study subjects.They were with the past history of total resection of the parathyroid gland.The improvement of cognitive function and quality of life in the patients before the surgery and one year after the surgery were statistically analyzed.Results Blood parathyroid hormone (iPTH),serum calcium,serum phosphorus,and alkaline phosphatase (ALP)were lower than those before surgery on the 1st,3rd,7th,14th,and 21stdays after surgery for parathyroidectomy,the level of hemoglobin(Hb)was higher than that before surgery,and the difference was statistically significant(P＜0.05);the MMSE score was(15.02±1.35)points at one year after the surgery,which was higher than that of(7.54±0.21)points before the surgery,and the difference was statistically significant(P＜0.05);at 1 year after surgery,the total score of SF-36 was significantly higher than that before surgery,and the difference was statistically significant(P＜0.05).The PF,RP,BP,and GH were significantly higher than those before the surgery,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in VT,SF,RE,and MH before and after the surgery (P＞0.05).The OHR score at one year after the surgery was significantly higher than that before the surgery,and the difference was statistically significant(P＜0.05).The SPL,EKD,and Sleep scores were higher than those before the surgery,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in the other items before and after surgery(P＞0.05).Conclusion Parathyroidectomy can improve the cognitive ability in the patients with uremia complicated with secondary hyperparathyroidism and effectively improve their quality of life,which is worthy of clinical promotion. 2018 Vol. 25 (11): 8-10转15 [Abstract] ( 169 ) HTML (37 KB)  PDF  (0 KB)  ( 29 ) 11 Meta analysis of the relationship between menopausal related hormone therapy and cognitive function RAN Hai-long;ZHAO Hong-qiong;YANG Zhu; LEI Xun;LIU Xiao-feng Objective To investigate the relationship between menopause hormone therapy (MHT)and cognitive function.Methods RCTs about MHT and cognition were published in databases PubMed,Embase,Cochrane library,CBM,CNKI,VIP and WANFANG DATA before November 2016 were searched.Meta-analysis was performed using STATA 12.0 software after quality assessment of the literature that met the inclusion and exclusion criteria.Results Eight studies,involving 17530 patients,were included.Meta-analysis suggested that:①The effects of MHT on increasing the risk of probable dementia(HR=1.78,95%CI[1.20-2.62],P=0.004)had significant difference.②The effects of MHT on increasing the risk of mild cognitive impairment(HR=1.21,95%CI[0.94-1.55],P=0.143)had no significant difference.③The effects of MHT on global cognitive function was negative(WMD=-0.21,95%CI[-0.33--0.09],P=0.001).④MHT had no significant effect on CVLT short delay free(WMD=0.14,95%CI[-0.11-0.38],P=0.277)and category fluency(WMD=-0.16,95%CI[-0.82-0.51],P=0.647).Conclusion The Meta-analysis has revealed that in postmenopausal women over 60 years of age MHT have an adverse impact on global cognitive function,increase the risk of dementia or mild cognitive impairment and have no significant difference in specific cognitive functions. 2018 Vol. 25 (11): 11-15 [Abstract] ( 198 ) HTML (44 KB)  PDF  (0 KB)  ( 35 ) 16 Simultaneous determination of 7 active components in Huangqi Hugan Capsules by high performance liquid chromatography JI Guo-li;LIU Bin Objective To establish a high performance liquid chromatography(HPLC)method for simultaneous determination of main components of Tetrahydropalmatine,Paeoniflorin,TanshinoneⅡA,Hesperidin,Emodin,Schisandrin A and Chrysophanol in Huangqi Hugan Capsules.Methods HPLC was used to detect the aforementioned components in Huangqi Hugan Capsules.The column was CNW Athena C18 and the mobile phase was methanol(A)and 0.1%aqueous solution of phosphoric acid(B)in gradient elution.The flow rate was 1.0 ml/min at 30℃column temperature.The detection wavelength were 210 nm for Tetrahydropalmatine,230 nm for Paeoniflorin,Hesperidin and Schisandrin A,and 265 nm for TanshinoneⅡA,Emodin,and Chrysophanol were 265 nm.The linear range,recovery,and repeatability of each component in Huangqi Hugan Capsules were examined.Results The linear ranges of Tetrahydropalmatine,Paeoniflorin,Hesperidin,Schisandrin A,Tanshinone ⅡA,Emodin and Chrysophanol were 1.26-25.20 μg/ml(r=0.9996),7.03-140.60 μg/ml(r=0.9998),3.63-72.60 μg/ml(r=0.9997),2.11-42.20 μg/ml(r=0.9994),1.98-39.60 μg/ml(r=0.9995),3.10-62.00 μg/ml(r=0.9996),and 2.28-45.60 μg/ml(r=0.9995).The average recovery of 7 components (n=6)was 99.6%,98.9%,98.7%,99.2%,98.2%,98.8%,and 98.2%,respectively.RSD was 1.7%,1.0%,1.2%,1.5%,1.2%,1.2%and 1.0%,respectively.Conclusion The method is accurate and reproducible in a high recovery,which can be used for quality control of Huangqi Hugan Capsules. 2018 Vol. 25 (11): 16-20 [Abstract] ( 191 ) HTML (44 KB)  PDF  (0 KB)  ( 35 ) 21 Influence of Polydatin on vascular function in the ApoE －/－ mice with atherosclerosis －/－ mice with atherosclerosis[J]. 中国当代医药, 2018,25(11): 21-24')" href="#"> LIN Yuan-yuan Objective To study the influence of Polydatin on vascular function in the ApoE-/-mice with atherosclerosis.Methods To prepare the mouse model with therosclerosis,16 ApoE-/-mice with high fat diet were selected.The model mice were randomly divided into the model group and the experimental group,and 8 normal mice were chosen as the control group.The experimental group was treated with Polydatin for 16 weeks,while the model group and the control group was not treated.After and before the treatment,the serum was collected,and the triglyceride(TG）,low density lipoprotein(LDL-c),tumor necrosis factor α (TNF-α),interleukin 1β (IL-1β),interleukin 6(IL-6),high sensitive C-reactive protein(hs-CRP),total antioxidant capacity(T-AOC),malondialdehyde(MDA),monocyte chemoattractant protein-1(MCP-1),high density lipoprotein(HDL-c),superoxide dismutase(SOD)and interleukin 10(IL-10)were detected by enzyme linked immunosorbent assay(ELISA).The tissue sections of mouse arterial blood vessels were made and the plaque area ratio of arterial blood vessels in each group was compared by oil red O staining.The plaque area ratio of arterial vessels in each group was compared.Results Before the treatment,compared with the control group,the level of TC,TG,LDL-c,TNF-α,IL-1β,IL-6,hs-CRP,T-AOC,MDA,MCP-1 in serum from the model group and the experimental group were significantly increased(P＜0.05);the level of HDL-c,SOD and IL-10 of that were significantly reduced(P＜0.05).After the treatment,compared with the model group,the level of TC,TG,LDL-c,TNF-α,IL-1β,IL-6,hs-CRP,T-AOC,MDA and MCP-1 in serum from the experimental group were significantly lower,and the HDL-c,SOD and IL-10 increased significantly(P＜0.05).And the area of arterial plaque decreased significantly(P＜0.05).Conclusion The Polydatin may relieve and prevent certain effect on atherosclerosis in ApoE-/-mice,reduce blood fat,inflammatory cytokines,chemokines,and increase serum immune function. 2018 Vol. 25 (11): 21-24 [Abstract] ( 174 ) HTML (45 KB)  PDF  (0 KB)  ( 32 ) 25 Application of hydrogel scaffolds in tissue engineering cartilage LIANG Liang;YAN Fei Cartilage injury and degeneration are common diseases which often lead to joint pain,dysfunction,and even disability.The repair and regeneration of cartilage defects has become a significant challenge,the rapid development of tissue engineering provides a new scheme for this problem.Hydrogel scaffolds are widely used in tissue engineering cartilage because of their similar structure with natural extracellular matrix,favorable for survival of seed cells,small trauma to implant,filling of any shape defect and closely connection with the host cartilage.This article reviews the progress of the application of hydrogel scaffolds constructed by different materials in tissue engineering cartilage. 2018 Vol. 25 (11): 25-28 [Abstract] ( 173 ) HTML (42 KB)  PDF  (0 KB)  ( 25 ) 29 Research progress of regulation of enteral nutritional components to intestinal immune system GUO Zhi-ying;XI Hong-wei;DUAN Wen-qiang;WANG Bo As a digestive organ of human body,the intestinal tract can maintain the normal nutrition of body,and it also has a special immune function.It plays an important role in the normal immune system of human body,and its dysfunction will lead to the occurrence of some diseases.More and more studies have shown that enteral nutrition supports the integrity of intestinal structure and function,and each nutrient component plays a key role in intestinal immune response and intestinal immune diseases.In this review,we focus on the regulation of enteral nutritional components to the intestinal immune system system. 2018 Vol. 25 (11): 29-31 [Abstract] ( 165 ) HTML (35 KB)  PDF  (0 KB)  ( 34 ) 32 Clinical study of the correlation between heart fatty acid binding protein and pulmonary arterial hypertension WANG Yu-hong;LI Min;LI Wei Objective To study the clinical correlation between heart fatty acid binding protein(H-FABP)and pulmonary arterial hypertension(PAH).Methods Ninety patients with PAH admitted to our hospital from April 2016 to April 2017(without distinguishing the type of pulmonary hypertension)were selected and divided into experimental group and control group.the experimental group was divided into light,medium and heavy subgroups according to the pulmonary artery pressure.Chronic thrombotic PAH,hypoxemia PAH and left heart disease-related PAH were classified according to etiology.The control group was 80 cases of health examination in the same period.H-fabp content in serum of patients was determined by double antibody sandwich ELISA,and creatine kinase isoenzyme(ckmb),troponin I(ctni),nt-pro BNP levels were detected and analyzed statistically.The follow-up time was 18 months and all-cause mortality was counted.Results The levels of H-FABP in PAH patients were significantly higher than those in healthy controls(P＜0.05).CKMB and cTNI showed no significant difference after inter-group comparison(P＞0.05).There was no significant difference in H-FABP levels among PAH patients in different etiologies(P＞0.05).After 1 year follow up visits,H-FABP was associated with all-cause mortality(P＜0.01).Conclusion PAH patients have high H-FABP level which can be used to evaluate the risk of pulmonary arterial pressure.H-FABP is an independent risk factor for all-cause mortality. 2018 Vol. 25 (11): 32-34 [Abstract] ( 175 ) HTML (35 KB)  PDF  (0 KB)  ( 26 ) 35 Comparison of clinical effect of resection of the posterior medial approach under arthroscopy and traditional surgical resection of popliteal cyst YE Heng;WU Ze-yang;SU Pei-qun Objective To analyze and compare the clinical effects of resection of the posterior medial approach under arthroscopy and traditional surgical resection of popliteal cyst.Methods Fifty-six patients with popliteal cyst admitted to our hospital from March 2015 to April 2018 were randomly divided into control group and study group,with 28 cases in each group.The control group received traditional surgical treatment,while the study group received arthroscopic posterior medial approach,the treatment status of the two groups was observed and compared,such as incision length,postoperative infection rate,bleeding volume,knee function and so on.Results The total incidence of complications in the study group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The amount of bleeding in the study group was less than that in the control group,the postoperative ambulation time and hospitalization time were shorter than those in the control group,Hospitalization expenses were lower than those in the control group and the differences were statistically significant(P＜0.05).There was no significant difference in Lysholm score between the two groups before operation(P＞0.05).One week after operation,Lysholm score in the study group was higher than that in the control group,and the difference was statistically significant.The recurrence of 0 cases(0%)in the study group was lower than that of 5 cases(17.86%)in the control group,and the difference was statistically significant(P＜0.05).The Rauschning grade in the study group was significantly higher than that in the control group,and the difference was statistically significan(P＜0.05).Conclusion The clinical treatment of popliteal cyst patients to meet the operation indication under the condition of the arthroscopic posteromedial approach resection of popliteal cyst surgery as the preferred way,which the traumatic are small,and can promote the postoperative recovery. 2018 Vol. 25 (11): 35-37 [Abstract] ( 194 ) HTML (32 KB)  PDF  (0 KB)  ( 31 ) 38 Compare the curative effect of self-retaining laryngoscope and conventional fiber laryngoscope in the resection of vocal cord polyps HE Shi-hao;ZHANG Shou-xia;CHEN Hui-lin Objective To compare the curative effect of self-retaining laryngoscope and conventional fiber laryngoscope in the resection of vocal cord polyps.MethodsFrom December 2014 to December 2016,98 patients with laryngeal vocal cord polyps were selected and divided into control group and study group according to the order of admission,49 cases in each group.The control group was treated with traditional fiberoptic laryngoscope,while the study group was treated with supportive laryngoscope.The clinical efficacy,postoperative complications and vocal cord dysfunction scores were compared between the two groups.Results The total effective rate of the study group was significantly higher than that of the control group,and the difference was statistically significant(P＜0.05).The postoperative complications rate in the study group was significantly lower than that in the control group,and the difference was statistically significant(P＜0.05).Before operation,there was no significant difference in VHI score between the two groups (P＜0.05).After operation,and the VHI score of the study group was significantly lower than that of the control group,and The difference was statistically significant(P＜0.05).Conclusion The self-retaining laryngoscope has a better effect than conventional fiber laryngoscope,can protect the vocal cord,reduce the incidence rate of complications. 2018 Vol. 25 (11): 38-40 [Abstract] ( 157 ) HTML (33 KB)  PDF  (0 KB)  ( 27 ) 41 Clinical effect of noninvasive positive pressure ventilation on elderly patients with chronic obstructive pulmonary disease complicated with severe respiratory failure WU Zhong-jun;TANG Jian;ZHOU Kui Objective To evaluate the clinical efficacy of noninvasive positive pressure ventilation(NIPPV)in the treatment of chronic obstructive pulmonary disease(COPD)complicated with severe respiratory failure in elderly patients.Methods A total of 94 elderly COPD patients with severe respiratory failure were selected from January 2014 to January 2016 treated in our hospital,and divided into control group and observation group according to random number table method,47 cases in each group.Patients in the experimental group were treated with NIPPV and patients in the control group were treated with conventional therapy.The PaO2,PaCO2,SpO2,HR and RR levels were observed before and after treatment,the complications were recorded and the clinical efficacy was evaluated.Results After one course of treatment,HR,RR,PaCO2,SpO2levels in the experimental group were lower than those in the reference group,and PaO2 levels in the reference group were lower than those in the experimental group,the differences were statistically significant(P＜0.05).The clinical effective rate of the experimental group was 87.23%(41/47)which was higher than that in the control group of 74.47% (35/47),the difference was statistically significant(P＜0.05).The incidence of complications in the experimental group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion The clinical treatment of elderly COPD with severe respiratory failure is effective,reducing the trachea intubation rate and complications,and can improve the prognosis and improve the clinical efficacy. 2018 Vol. 25 (11): 41-43 [Abstract] ( 171 ) HTML (35 KB)  PDF  (0 KB)  ( 26 ) 44 Effectivenessevaluation ofholmium laserlithotripsy underflexible ureteroscope in the treatment of renal calculi YAN Xi-xin;HONG Zhi-jian;YAO Jin-shu Objective To investigate the clinical effect of holmium laser lithotripsy under flexible ureteroscope(F-URS)for renal calculi.Methods From March 2016 to March 2017,118 patients with renal calculus were selected as the research objects,and divided into lithotripsy group and traditional group according to the different treatment methods,59 cases in each group.The traditional group was treated with open lithotomy and the lithotripsy group was treated with holmium laser lithotripsy under ureteroscopy.The therapeutic effect,the changes of operative indexes,postoperative fever rate,pain rate and stone removal rate were observed and compared between the two groups.Results The effective rate of lithotripsy group was significantly higher than that of traditional group,and the difference was statistically significant(P＜0.05).The operation time,ambulation time and hospitalization time of patients in lithotripsy group were shorter than those in traditional group,and the intraoperative blood loss was less than that in traditional group,and the differences were statistically significant(P＜0.05)；the stone clearance rate,postoperative pain rate and postoperative fever rate in lithotripsy group were lower than those in traditional group,and the differences were statistically significant(P＜0.05).Conclusion In the treatment of patients with renal calculi,holmium laser lithotripsy under F-URS can not only reduce the incidence of postoperative pain and fever,but also shorten the postoperative rehabilitation time.To some extent,it is conducive to the recovery of patients,and the therapeutic effect is remarkable. 2018 Vol. 25 (11): 44-46 [Abstract] ( 154 ) HTML (31 KB)  PDF  (0 KB)  ( 25 ) 47 Clinical effect comparison of different insulin delivery methods on diabetes mellitus YU Li-qin Objective To explore the clinical effect of different insulin delivery methods on diabetes mellitus(DM).Methods 91 cases DM patients from June 2016 to August 2017 were selected as research objects in our hospital.They were divided into control group(n=42)and treatment group(n=49)according to the mode of administration.In the control group,subcutaneous insulin therapy was used,while in the treatment group,insulin pump infusion therapy was adopted.The clinical efficacy of the two groups was compared.Results The total effectiveness rate of the treatment group was 95.92%,significantly higher than that in the control group accounting for 83.33%,with a significant difference(P＜0.05).The fasting blood glucose level in the treatment group after therapy was(6.23±0.85)mmol/L,lower than that in the control group(7.15±1.23)mmol/L.The time of fasting blood glucose meeting the standard in the treatment group was shorter,and the average insulin dose was lowerer compared with those in the control group,with statistical differences(P＜0.05).The incidence of hypoglycemia was 2.04%,lower than that in the control group accounting for 14.29%,with a statistical difference (P＜0.05).Conclusion Insulin treatment in DM patients,insulin pump therapy can reduce the insulin dose in high effect,greatly improve the fasting blood glucose,and benefit patient′s glycemic control,and play an important application value in clinical treatment. 2018 Vol. 25 (11): 47-49 [Abstract] ( 160 ) HTML (31 KB)  PDF  (0 KB)  ( 35 ) 50 Effect of Cinepazide and Mecobalamin on nerve conduction velocity,VPT and serum parameters in patients with diabetic peripheral neuropathy LUO Hong Objective To investigate the effects of Cinepazide and Mecobalamin on the nerve conduction velocity,vibration perception threshold(VPT)and serum parameters in diabetic peripheral neuropathy(DPN)patients.Methods Eighty DPN patients treated in our hospital from March 2015 to March 2017 were selected as the subjects,and divided into observation group(Cinepazide and Mecobalamin therapy)and reference group(sole Mecobalamin),with 40 cases in each group according to the method of parallel control.The nerve conduction velocity,the VPT level and serum parameters before and after treatment were compared between the two groups.Results Before and after treatment,the nerve conduction velocity was significantly different between the two groups(P＜0.05).After the treatment,the nerve conduction velocity in various parts in the observation group was significantly greater than that of the reference group,the difference was statistically significant(P＜0.05).The VPT values of the two groups before and after treatment were significantly different(P＜0.05).After treatment,the decrease of VPT in the observation group was more remarkable compared with that in the reference group (P＜0.05).The levels of serum HMGB1,Hcy,MDA,NSE and S100β in the two groups before and after treatment were significantly different(P＜0.05).Each parameter in the observation group was statistically different from that in the reference group (P＜0.05).Conclusion Combination of cinepazide and mecobalamin in the treatment of DPN can promote microcirculation and recovery of damaged nerve function,and obtain a remarkable effect. 2018 Vol. 25 (11): 50-52转56 [Abstract] ( 149 ) HTML (36 KB)  PDF  (0 KB)  ( 28 ) 53 The efficacy of exercise therapy combined with Insulin Lispro in treatment of elderly patients with type 2 diabetes XIAO Xiao-hong;CHENG Hui-fang;XIONG Hu;XIANG Bing;XU Wei-jian;JIN Fang Objective To explore the curative effect of exercise therapy combined with Insulin Lispro in treatment of elderly patients with type 2 diabetes mellitus.Methods From August 2015 to July 2017,80 patients with type 2 diabetes mellitus treated in our hospital were selected as research objects,and they were randomly divided into the control group and the observation group,40 cases in each group.The control group was treated with Insulin Lispro,while the observation group was treated with exercise therapy based on the control group.Both groups were examined before and 3 months after treatment.The fasting plasma glucose(FPG),2 hour postprandial blood glucose(2 h PG),Glycated albumin(GA),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),body mass index(BMI)and 6 minutes walk test were compared.Results The FPG,2 h PG,GA,HbA1c,TC,TG and BMI after treatment in the observation group were lower than those before treatment,and the decrease in observation group was significantly higher than that in control group (P＜0.05).The 6-minute walking test after treatment in observation group was higher than those before treatment,and the rise in observation group was significantly higher than that in control group(P＜0.05).There was no significant difference in TC,TG,BMI and 6-minute walking test between the two groups after treatment(P＞0.05).Conclusion The combination of Insulin Lispro and exercise therapy can reduce blood glucose levels,ease blood lipid disorders,loss weight,improve exercise capacity,reduce complications and reduce cardiovascular disease risk. 2018 Vol. 25 (11): 53-56 [Abstract] ( 181 ) HTML (40 KB)  PDF  (0 KB)  ( 31 ) 57 Short-term effect and safety analysis of laparoscopic radical total gastrectomy in the treatment of upper gastric cancer XIN Le;YE Jin-jun;YAN Yu-kuang;BAO Xing Objective To study and evaluate the short-term effect and safety of laparoscopic radical total gastrectomy in the treatment of upper gastric cancer.Methods60 patients with upper gastric cancer were selected in our hospital from January 2014 to June 2017 were randomly divided into observation group and control group according to random number table method.30 cases in each group.In the control group,radical gastrectomy by traditional laparotomy was used,while in the observation group,laparoscopic total gastrectomy was performed.The number of lymph node dissection,operative conditions,postoperative pain score,postoperative recovery time,incidence of complications and immune function were compared between the two groups.Results There was no significant difference in operative time between the two groups(P＞0.05).However,the number of lymph node dissection in the observation group was more than that in the control group(P＜0.05).The intraoperative blood loss was less than that in the control group(P＜0.05).Pain scores in the observation group were lower than those in the control group at 8,12,24 and 48 h after operation(P＜0.05).The indexes of postoperative exhaust recovery time,time of being off bed independently,time to consume liquid food,and hospital stay,etc.in the observation group were shorter than those in the control group(P＜0.05).The total incidence of postoperative complications in the observation group was 3.33%,while that in the control group was 20.00%which differed significantly(P＜0.05).The indexes of immune function in the control group after operation were all lower than those before operation,the differences were statistically significant(P＜0.05).While those in the observation group were not statistically significant before and after operation(P＞0.05).Conclusion Laparoscopic radical total gastrectomy for the treatment of upper gastric cancer can alleviate the surgical trauma,postoperative pain and immune impairment,reduce postoperative complications,promote postoperative recovery,and effectively clear lymphatic nodes with a significant short-term effect. 2018 Vol. 25 (11): 57-59转65 [Abstract] ( 175 ) HTML (37 KB)  PDF  (0 KB)  ( 36 ) 60 Clinical observation of whole-process nutrition management on concurrent chemoradiotherapy for head and neck neoplasm WU Jian;WU Kun-peng;LIU Zhuo-xing Objective To investigate the effect of whole-process nutrition management on concurrent radiotherapy and chemotherapy and influence on the nutritional status before and after radiotherapy and chemotherapy in patients with head and neck neoplasm.Methods A total of 66 patients with head and neck tumors treated with concurrent chemoradiotherapy in our department from January 2014 to November 2017 were divided into observation group and control group by a random number table,33 cases in each group.In the control group,the clinical routine method was used,in the observation group,the whole-process nutrition management was provided during and one month after radiotherapy and chemotherapy.The radiochemotherapy efficacy and nutritional status before and after radiotherapy and chemotherapy were compared between the two groups.Results The total effectiveness rate of radiotherapy and chemotherapy in the observation group was 93.9%,significantly higher than that in the control group accounting for 72.7%(χ2=5.345,P=0.021).Before radiotherapy and chemotherapy,the nutritional indicators of the two groups were not displayed statistical significance after comparison(P＞0.05).At the end of radiotherapy and chemotherapy,the indicators such as body mass,hemoglobin,albumin,and prealbumin were lower than those before radiotherapy,but these nutritional indicators in the observation group were all higher than those in the control group during the same period,which were displayed statistical differences(P＜0.05).Conclusion The whole-process nutrition management can improve the nutritional status of concurrent radiotherapy and chemotherapy in patients with head and neck tumors,ensure the compliance of radiotherapy and chemotherapy,and is beneficial to enhancing the clinical efficacy. 2018 Vol. 25 (11): 60-62 [Abstract] ( 178 ) HTML (32 KB)  PDF  (0 KB)  ( 26 ) 63 Clinical effect of Elemene combined with Cisplatin in the treatment of pleural effusion caused by lung cancer LIU Yan Objective To investigate the clinical effect of Elemene combined with Cisplatin in the treatment of pleural effusion caused by lung cancer.Methods From September 2015 to September 2017,68 lung cancer patients combined with pleural effusion treated in our hospital were selected as research objects.They were randomly divided into treatment group and control group,34 cases in each groups.In the treatment group,Intrapleural Injection of Elemene combined with Cisplatin was used,while in the control group,only Cisplatin Injection via thoracic cavity was provided.The clinical therapeutic effect in the two groups was observed.Results The therapeutic effectiveness rate in the treatment group was greatly superior to that in the control group,the difference was statistically significant(P＜0.05).No statistical difference in the incidence of adverse reactions was displayed(P＞0.05).Conclusion Elemene combined with Cisplatin is effective in the treatment of pleural effusion caused by lung cancer,with few adverse reactions,safe and reliable,which has a clinical application value. 2018 Vol. 25 (11): 63-65 [Abstract] ( 175 ) HTML (29 KB)  PDF  (0 KB)  ( 37 ) 66 Clinical efficacy and safety of albumin-bound paclitaxel in patients with advanced cervical cancer LAI Yi-duan Objective To evaluate the clinical efficacy and safety of albumin-bound paclitaxel in patients with advanced cervical cancer.Methods 40 patients with advanced cervical cancer who were treated in our hospital from January 2014 to January 2017 were selected as study subjects and divided into study group(20 cases)and control group(20 cases)by computer randomization method.The study group was adopted Albumin-bound paclitaxel chemotherapy treatment,the control group was used paclitaxel chemotherapy treatment.After treatment,the maximum diameter of tumor,symptom relief time,quality of life score,clinical remission rate and incidence of adverse reactions were compared between the two groups.Results The clinical remission rate of the study group was 95.00%,which was higher than that of the control group(55.00%),the difference was statistically significant(P＜0.05).The maximum diameter,symptom relief time and quality of life scores of the study group were higher than those of the control group.The differences were statistically significant(P＜0.05).The incidence of adverse reactions in the study group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion The application of albumin-bound paclitaxel to patients with advanced cervical cancer has certain drug safety and can greatly improve the clinical efficacy of the patients. 2018 Vol. 25 (11): 66-68 [Abstract] ( 168 ) HTML (31 KB)  PDF  (0 KB)  ( 30 ) 69 Effect of Zoledronic Acid combined with NP chemotherapy treating bone metastasis of breast cancer DENG Hui-jun;PENG Yu-long;CAO Yong-xin;CHEN Rong-hui;ZHANG Lu;LIU Gui-hong Objective To investigate the effect of Zoledronic Acid combined with NP chemotherapy treating bone metastasis of breast cancer.Methods A total of 110 breast cancer patients with bone metastasis from January 2015 to January 2017 in our hospital were enrolled as research objects.They were randomly divided into group A(n=55,NP chemotherapy alone)and group B (n=55,Zoledronic Acid combined with NP chemotherapy).The treatment effect and incidence of complications were compared between the two groups.Results The excellent and good rate of treatment effect in group B was 87.27%,which was significantly higher than 70.91%that in group A,with a statistical difference(P＜0.05).There was no significant difference in adverse reactions between group A and group B(12.73%vs.10.91%,P＞0.05).Conclusion Zoledronic Acid combined with NP chemotherapy in the treatment of bone metastasis of breast cancer can obtain a significant effect in high safety. 2018 Vol. 25 (11): 69-70转74 [Abstract] ( 165 ) HTML (27 KB)  PDF  (0 KB)  ( 27 ) 71 A comparative study of laparoscopic radical colectomy and open radical colorectal resection for senile patients with colorectal cancer CHEN Dan;ZHANG Wei-bin;WU Min-hua Objective To investigate the clinical efficacy of laparoscopic radical colectomy and open radical colorectal resection for senile patients with colorectal cancer.Methods A total of 112 senile patients with colorectal cancer enrolled in the First Affiliated Hospital of Guangdong Pharmaceutical University from June 2010 to June 2013 were selected as research objects.The patients were divided into laparoscopic group (n=57)and laparotomy group (n=55),according to different operation methods.The following indexes of the two groups were compared：operation time,number of resected lymph nodes,intraoperative bleeding loss,postoperative ambulation time,gastrointestinal function recovery time,complications(incision fat liquefaction and infection,anastomotic bleeding,anastomotic fistula,ileus,deep vein thrombosis,cerebral infarction and pulmonary infection incidence rate and total hospitalization time.The survival rate and recurrence rate of the two groups were compared at 1,2 and 3 years after operations.Results There was no significant difference in the operation time and the number of resected lymph nodes in the two groups(P＞0.05).The amount of bleeding in the laparoscopic group was significantly reduced(P＜0.05).The postoperative ambulation time,gastrointestinal function recovery time and total hospitalization time in the laparoscopic group was significantly shortened(P＜0.05).Postoperative complications such as incision fat liquefaction and infection,anastomotic bleeding,anastomotic fistula,adhesive ileus,deep vein thrombosis,cerebral infarction and pulmonary infection rate of the laparoscopic group were lower than those in the laparotomy group,and the differences were statistically significant(P＜0.05).The survival rates at 1,2,and 3 years after the operation were 100.00%,92.89%and 91.22%in the laparoscopic group and 98.18%,92.72%and 90.90%in the laparotomy group.The recurrence rates at 1，2，and 3 years after the operation were 3.50%，5.26%and 8.77%in the laparoscopic group,and 3.63%,5.45%and 10.90%in the laparotomy group.There was no significant difference in the survival rate and recurrence rate between the two groups(P＞0.05).Conclusion Laparoscopic radical surgery for elderly patients with colorectal cancer is safe and feasible,and its clinical effect is superior to traditional open radical surgery,and has a good application prospect. 2018 Vol. 25 (11): 71-74 [Abstract] ( 168 ) HTML (36 KB)  PDF  (0 KB)  ( 24 ) 75 Transurethral holmium laser bladder resection and bladder tumor resection for superficial bladder cancer SU Xue-yong;PAN Xiang;LIU Yong-chang Objective To investigate the clinical effect of transurethral holmium laser bladder tumor resection and bladder tumor resection for superficial bladder cancer.Methods 50 patients with superficial bladder cancer admitted from December 2012 to October 2017 in our hospital were divided into observation group(n=25)and control group according to random number table method.The observation group was treated by transurethral holmium laser bladder tumor resection,while the control group was treated by transurethral resection of bladder tumor.The operation time,intraoperative blood loss,length of indwelling catheter,days of hospitalization,levels of inflammatory cytokines before and after treatment and complication rates were compared between the two groups.Results The operation time,indwelling catheter length,length of hospital stay were shorter than those in control group,intraoperative blood loss was losser than those in the control,IL-6,IL-8,TNF-α and complication rates in observation group were significantly lower than those in control group,and IL-10 level was higher than that in control group,the differences were statistically significant(P＜0.05).Conclusion Transurethral resection of holmium laser bladder tumor and resection of bladder tumor have some effect on superficial bladder cancer,but transurethral resection of holmium laser bladder tumor is more effective,which can shorten the length of hospital stay and reduce the cost of the patient Burden,and less impact on inflammatory cytokines,fewer complications，with high clinical value. 2018 Vol. 25 (11): 75-77 [Abstract] ( 160 ) HTML (34 KB)  PDF  (0 KB)  ( 30 ) 78 Correlation analysis of nasopharyngeal carcinoma in Epstein-Barr virus positivity and regulatory T cells ZHONG Qi-long;FU Guo-wu;LIANG Xiao-ming Objective To analyze the correlation between nasopharyngeal carcinoma in Epstein-Barr（EB） virus positivity and regulatory T cells and to explore its reference value for the clinical diagnosis and prognosis of the disease.Methods 35 patients with EB virus positivity of nasopharyngeal carcinoma admitted in our hospital from April 2015 to February 2017 and 40 healthy participants during the same period undergoing physical examinations in our hospital were selected as research objects.They were divided into observation group and control group respectively.Fasting venous blood was collected from the two groups to detect the level of regulatory T cells.The difference between the detection results of nasopharyngeal carcinoma patients with EB virus positivity and healthy participants was compared,and the change of regulatory T cell levels before and after treatment were observed.Results The levels of CD4+CD25+Foxp3+Treg and CD4+CD25+Foxp3+Treg/CD4+T of regulatory T cells in the observation group were significantly higher than those in the control group with significant differences between the two groups(P＜0.05).After treatment,the levels of CD4+CD25+Foxp3+Treg and CD4+CD25+Foxp3+Treg/CD4+of regulatory T cells in the observation group were lower than that in the before treatment,with statistical differences(P＜0.05).Conclusion The occurrence and development of nasopharyngeal carcinoma in EB virus positivity may cause the change of regulatory T cell levels in patients.By detecting the level of regulatory T cells,it to a certain extent can reflect the patient′s condition and the recovery after treatment,which has an important reference value for the clinical diagnosis and prognosis of the disease. 2018 Vol. 25 (11): 78-80 [Abstract] ( 165 ) HTML (40 KB)  PDF  (0 KB)  ( 29 ) 81 Clinical analysis of laparoscopic endometrioma lesionectomy LIU Qin;OUYANG Juan;TAN Xiao-qiang;CHENG Jing-xin Objective To study the clinical effect of laparoscopic surgery in patients with adenomyosis.Methods 40 patients with adenomyosis who underwent surgeries in our hospital from December 2015 to June 2017 were enrolled.They were evenly divided into control group and treatment group by a mathematical random list.In the control group,abdominal endometrioma lesionectomy was used,while in the treatment group,laparoscopic endometrioma lesionectomy was adopted.The operation time,intraoperative blood loss,postoperative hospital stay,satisfaction on surgical treatment of adenomyosis,surgical effect,rate of recurrence after surgery,frequency of visiting hospital due to postoperative recurrence,and hospitalization expenses were compared between the two groups.Results The operation time and postoperative hospital stay in the treatment group were both shorter than those in the control group(P＜0.05).The intraoperative blood loss was(32.56±5.17)ml,less than that in the control group(109.54±21.70)ml,(P＜0.05).In the treatment group,the total satisfaction on surgical treatment of adenomyosis was 95.0%,and the total effectiveness rate of surgical treatment was also 95.0%,much higher than those in the control group accounting for 80.0%and 75.0%respectively,which were displayed statistical significance(P＜0.05).The cost of hospitalization in the treatment group was lower than that of the control group(P＜0.05).The rate of postoperative recurrence and frequency of visiting hospital due to postoperative recurrence in the treatment group were less than those in the control group,the differences were statistically significant(P＜0.05).Conclusion Adenomyosis patients using laparoscopic surgery for removal can shorten the operation and postoperative recovery time,minimize the amount of intraoperative bleeding,and effectively ameliorate the symptoms of adenomyosis,and improve the treatment effect,economic benefits,and patient′s satisfaction simultaneously. 2018 Vol. 25 (11): 81-83 [Abstract] ( 167 ) HTML (33 KB)  PDF  (0 KB)  ( 30 ) 84 Application effect comparison of new and old labor standards in puerperae SHANG Li-li;ZHU Fang;BU Xiu-hua Objective To compare the application effect of new and old labor standards in puerperae.Methods A total of 100 maternal women who gave birth using the new labor standard from January 2016 to June 2017 in our hospital were selected as observation group.During the same period,100 puerperae used old labor standard were employed as control group.All patients were primiparae.The time of labor stages including first stage of labor,second stage,and total labor stage were compared in the two groups.The delivery modes such as cesarean section,vaginal assistant labor,natural childbirth were compared in the two groups.The patient′s delivery outcomes including postpartum hemorrhage,the incidence of neonatal asphyxia were observed in the two groups.Results In the observation group,the first stage of labor,the second stage of labor and the total stage of labor were all shorter than those in the control group.The oxytocin use rate was significantly lower than that in the control group,which displayed statistical differences(P＜0.05).In the observation group,the incidence of spontaneous labor was higher and vaginal assistant labor was lower compared with the control group(P＜0.05).There was no statistical difference between the two groups in cesarean section(P＞0.05).The proportions of postpartum hemorrhage,neonatal asphyxia and umbilical arterial blood pH＜7.00 in the observation group were all significantly lower than those in the control group(P＜0.05).Conclusion The new labor standard in puerperae can significantly decrease the vaginal assistant labor rate and cesarean section transferring rate and reduce neonatal asphyxia,which can be extensively used in clinic. 2018 Vol. 25 (11): 84-86 [Abstract] ( 161 ) HTML (31 KB)  PDF  (0 KB)  ( 28 ) 87 Effect of nasal endoscopic low-temperature plasma radiofrequency ablation on stress response and ventilatory function in children with snoring YAN Wei-hong;LAN Jian-ping;LI Ke Objective To explore the effect of nasal endoscopic low temperature plasma ablation in the treatment of children′s snoring stress and ventilation function,to provide a reliable basis for clinical.Methods A total of 116 children with pediatric snoring were selected from May 2014 to June 2016.They were divided into experimental group and reference group according to random number table method,58 cases in each group.The experimental group was treated with low temperature plasma ablation of nasal endoscopy,adenoidectomy and tonsilectomy were used in the reference group.The degree of stress response and the effect of ventilation were compared between the two groups after operation.Results After operation 24 h,the content of glutathione(GSH)and superoxide dismutase(SOD)were higher than that in the reference group,the differences were statistically significant(P＜0.05).The levels of sleepout(AHI),oxygen deficit(ODI),oxygen saturation less than 90%of sleep time(SLT 90%),and longest apnea were observed 6 months after surgery(LAT)were significantly lower than those in the reference group,the lowest nocturnal oxygen saturation(LSaO2)was significantly higher than that in the reference group,the differences were statistically significant(P＜0.05).Conclusion The use of nasal endoscopic low temperature plasma ablation in the treatment of pediatric snoring has a significant clinical effect,the operation can relieve the stress response after surgery in children,improve the ventilation after surgery,it is worthy of clinical application. 2018 Vol. 25 (11): 87-89 [Abstract] ( 157 ) HTML (34 KB)  PDF  (0 KB)  ( 32 ) 90 The effect of improved chloral hydrate retention enema combined with sedation assessment tool on the sedation effect of infants WANG Ting-ting;LI Jie Objective To investigate the sedation effect of improved chloral hydrate retention enema with sedation assessment tool in infants and young children′s auxiliary examination.Methods A convenience sampling method was used to select 300 infants and young children who received chloral hydrate retention enema in the auxiliary examination from June 2016 to February 2017.They were divided into the control group and the observation group according to the different wards,150 cases in each group.The control group was treated with traditional chloral hydrate retention enema.The observation group was treated with improved chloral hydrate retention enema and the sedative assessment tool was used to judge the degree of sedation.The drug spillover and the sedative effect of two groups of infants and young children after retention enema were compared.Results The spillover of the enema fluid in the observation group was less than that in the control group,and the sedation effect was better than that in the control group.There are statistically significant differences in comparison(P＜0.01).Conclusion The improved chloral hydrate retention enema method can reduce the spillover of liquid and increase the retention time of drugs in the intestine.Combined with sedation assessment tools,it can accurately judge the degree of sedation and enhance the sedative effect. 2018 Vol. 25 (11): 90-92 [Abstract] ( 134 ) HTML (34 KB)  PDF  (0 KB)  ( 27 ) 93 Clinical study of biofeedback and oral administration of Desmopressin Acetate in the treatment of primary enuresis in children MAN Xing-yu;ZOU Xian Objective To investigate the clinical effect of biofeedback and oral administration of Desmopressin Acetate in the treatment of primary enuresis in children.Methods The clinical data of 60 children with primary enuresis admitted from March 2015 to March 2017 in our hospital were analyzed.According to the different treatment measures,they were evenly divided into control group(behavioral therapy)and observation group(biofeedback+oral administration of Desmopressin Acetate),30 cases in each groups.Before and after treatment，the urine osmotic pressure,antidiuretic hormone(ADH)and the total effectiveness rate in the two groups were observed.Results Before treatment，urinary osmotic pressure and ADH in children with primary enuresis were not significantly different(P＞0.05).The urinary osmotic pressure and ADH in children both in the control group and observation group after treatment were higher than those before.After therapy,the two indexes in the observation group were superior to those in the control group(P＜0.05).The total clinical effectiveness rate in the observation group was higher than that in the control group,the differences were statistically significant(P＜0.05).Conclusion The biofeedback and oral administration of Desmopressin Acetate can significantly improve primary enuresis in children in a favorable effect,which is worthy of clinical promotion and application. 2018 Vol. 25 (11): 93-95 [Abstract] ( 146 ) HTML (31 KB)  PDF  (0 KB)  ( 35 ) 96 Research on the clinical effect of B ultrasound in the incidence rate of the neonate′s birth defect at the second trimester CHEN Xiao-ying Objective To observe the clinical effect of the prenatal examination of B ultrasound in the incidence rate of the neonate′s birth defect at the second trimester.Methods 1897 second trimester of pregnant women checked from January 2015 to January 2016 in our hospital were selected as research subjects.The four-dimensional ultrasound technique was used to observe the neonates′growth conditions in determining whether there were congenital malformation and whether it was necessary to take the intervention measures(labor induction).According to the B ultrasound examination results,pregnancy outcomes and labor induction conditions,the detection accuracy of B ultrasound was analyzed.Results According to the B ultrasound examination results,there were 26 neonates of birth defects(1.37%)including 8 cases of severe ventricular dilation,3 cases of cleft palate,3 cases of brightly spotted heart,2 cases of pyelectasis,1 case of flexion of the joints,2 cases of gastrointestinal malformation,3 cases of polydactyly,3 cases of scoliosis and 1 case of?strephenopodia.The detection accuracy of B ultrasound was 92.9%.Conclusion The B ultrasound is an important method of examining the neonate′s growth and screening the birth defects,can display whether the neonates have the malformations. 2018 Vol. 25 (11): 96-98转101 [Abstract] ( 131 ) HTML (32 KB)  PDF  (0 KB)  ( 30 ) 99 The effect of painless labor on primiparae and its influence on maternal and infant outcomes ZHANG Qiao-ying Objective To investigate the clinical effect of painless labor on primiparae and its influence on maternal and infant outcomes.Methods A total of 88 primiparae delivered in a selective time in our hospital from September 2016 to November 2017 were selected as research objects.By a random number table,they were evenly divided into control group and experimental group.In the control group,conventional delivery was used,while in the experimental group,painless labor was adopted.The analgesic effect,labor duration(first stage of labor,second stage of labor，and total labor)and maternal and infant outcomes including postpartum amount of bleeding,transfer to cesarean section,neonatal Apgar score,and complications,and lactation activity time of primipara were compared between the two groups.Results After different delivery,the excellent and good rate of anesthetic effect in primiparae in the experimental group was 97.73%,while 22.73%in the control group.The rate in the experimental group was significantly better than that in the control group(P＜0.05).In the experimental group,the time of the first labor stage and total labor duration were(9.45±2.11)h and(10.43±2.22)h，both of which were significantly shorter than those in the control group(P＜0.05).The difference in the second labor stage between the two groups was not significant(P＞0.05).On comparing the maternal and infant outcomes,the rate of transferring to cesarean section and incidence of complications were 4.55%and 11.36%in experimental group respectively,which were both lower compared with those in the control group(P＜0.05).The amount of postpartum hemorrhage was (203.51±28.49)ml in the experimental group,and the neonatal Apgar score was (9.65±1.32)points,which were not displayed statistical differences compared with the control group (P＞0.05).The time of lactation activity in the experimental group was(17.64±2.64)h,significantly shorter than that of the control group(P＜0.05).Conclusion The application of painless labor in primiparae can shorten the labor process and improve the maternal and infant outcomes,which is worthy of promotion in the future. 2018 Vol. 25 (11): 99-101 [Abstract] ( 153 ) HTML (31 KB)  PDF  (0 KB)  ( 34 ) 102 Preventive effect observation of fissure sealant combined with fluoride protective paint on children dental caries SONG Xin-hua;LIU Bing-xiang Objective To investigate the effect of fissure sealant combined with fluoride protective paint on prevention of dental caries in children.Methods A total of 120 children aged 6 to 10 years admitted to Pingxiang MCH from December 2014 to December 2015 were selected as the subjects,and randomly divided into group A,group B and control group,40 cases in each group.Children in group A were treated with pit and fissure sealant for prophylaxis and treatment.Children in group B were treated with pit and fissure sealant combined with fluoride protective paint for prophylaxis and treatment.Children in control group were routinely brushied.All subjects were followed up,the incidence of caries in children and the incidence of caries in the adjacent cavities,as well as the detachment of children in group A and B were compared.Results After follow-up,the incidence of dental caries was 12.50%in group A and 8.00%in group B,which were significantly better than those in control group(P＜0.05).The incidence of caries in group A was 6.00%.The incidence of caries in the adjacent group in group B was 2.00%,which were significantly better than those in the control group(P＜0.05).After 6 months,both groups of children′s blocking agent remained intact.After 12 months,7 cases in group A appeared partial shedding,while the children in group B remained intact.After 24 months,14 cases in group A appeared partial shedding,accounting for 35.0%,9 cases were completely detached,accounting for 22.5%,maintaining the complete rate of 42.5%.There were 3 cases of partial detachment in group B,accounting for 7.5%.There was no complete detachment,and the complete rate was 92.5%.The difference was statistically significant(P＜0.05).Conclusion The use of pit and fissure sealant combined with fluoride protective paint in the prevention of dental caries in children can effectively reduce the incidence of dental caries in children and the incidence of dental caries.The exact effect is achieved.At the same time,the sealant maintains a higher completeness rate and has a better preventive effect. 2018 Vol. 25 (11): 102-104 [Abstract] ( 141 ) HTML (33 KB)  PDF  (0 KB)  ( 30 ) 105 Influence of Mitomycin C on the stability of tear film after pterygium surgery JIANG Hui-feng;OUYANG Jun Objective To investigate the influence of Mitomycin C the stability of tear film after pterygium surgery.Methods A total of 86 (138 eyes)patients with primary pterygium admitted into our hospital from January 2016 to May 2017 were selected,and randomly divided into pterygium excision with amniotic membrane transplantation (group A)and pterygium excision combined with amniotic membrane transplantation and mitomycin C(MMC)group(group B).The tear secretion test(Schirmer I),break-up time(BUT)of the tear film and corneal fluorescein staining(CFS)examination were performed before surgery,1 and 3 months after surgery.Results One month after operation,the CFS and BUT of the two groups were significantly different from those before operation(P＜0.05).There were significant differences in the two indicators after inter-group comparison(P＜0.05).One month after surgery,there was no significant difference in SIt before surgery or after inter-group comparison(P＞0.05).Three months after operation,no great difference was displayed in CFS,BUT,or SIt compared with prior surgery or between the two groups (P＞0.05).Conclusionpterygium resection in early stage has some influence on the function of tear film.Three months after surgery,the function of tear film becomes basically normal.Compared with pterygium excision combined with amniotic membrane transplantation and MMC,the impact on the function of tear film by pterygium excision and amniotic membrane transplantation at early stage is milder. 2018 Vol. 25 (11): 105-107 [Abstract] ( 140 ) HTML (32 KB)  PDF  (0 KB)  ( 24 ) 108 Therapeutic effect of artificial tear gel combined with Hypromellose 2910,Dextran 70 and Glycerol Eye Drops on xerophthalmia JIANG Hong-yan;SUN Yun-yun Objective To study the clinical effect of Hypromellose 2910,Dextran 70 and Glycerol Eye Drops combined with artificial tear gel on patients with xerophthalmia.Methods From March 2016 to May 2017,86 patients with dry eye treated in our hospital were enrolled as research objects.According to the successive sequence of treatment time,patients were divided into control group(n=43)and research group(n=43).In the control group,Carbomer Eye Gel was used,while in the research group,on the basis of the control group,Hypromellose 2910,Dextran 70 and Glycerol Eye Drops was added.The tear film break-up time,tear secretion time,corneal fluorescein staining score as well as the total effectiveness rate between the two groups were compared.Results The total clinical effectiveness rate was 95.35%in the research group,significantly higher than that in the control group accounting for 81.40%,with a statistical difference (P＜0.05).The tear secretion time and tear film break-up time were longer in the research group than those in the control group,and the corneal fluorescein staining score in the research group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion In the treatment of patients with xerophthalmia,combination of Hypromellose 2910,Dextran 70 and Glycerol Eye Drops and Carbomer Eye Gel can effectively alleviate patient’s symtoms in a remarkable effect and has a high application value. 2018 Vol. 25 (11): 108-110 [Abstract] ( 144 ) HTML (32 KB)  PDF  (0 KB)  ( 30 ) 111 Clinical effect of eyelid massage combined with Polyethylene Glycol eyedrops in the treatment of xerophthalmia ZHOU Ming-bo;WANG Jin;2HAO Ji-long Objective To explore the clinical effect of combining eyelid massage with Polyethylene Glycol eye drops in the treatment of xerophthalmia.Methods From October 2015 to October 2017,222 patients with xerophthalmia treated in First Hospital of Bethune in Jilin University were selected as the subjects,and divided into two groups according to the time of treatment.The single group(111 cases)were treated with eyelid massage alone,and the combined group(111 cases)were treated with eyelid massage combined with Polyethylene Glycol eye drops treatment.The therapeutic effects of the two groups were analyzed and compared.The scores of dry eye symptom,tear film rupture time,corneal fluoresce in staining score and basal tear secretion test were compared before and after intervention.Results The combined group had a total effective rate of 90.99%,which was significantly different from that of the single group(81.08%)(P＜0.05).After treatment,the dry eye symptom score of the combined group was(3.12±0.25)points,membrane rupture time was(12.88±3.52)s,corneal fluorescein staining score was(1.05±0.90),basal lacrimal secretion test was(6.38±1.14)mm/5min.The dry eye symptom score of the single group was(5.01±1.12)scores,tear film rupture time was(8.33±1.99)s,corneal fluorescein staining score was(4.22±1.53)points,and basal tear secretion test was(5.03±0.56)mm/5 min.The difference was statistically significant between the two groups(P＜0.05).Conclusion The combination of eyelid massage and Polyethylene Glycol eye drops for xerophthalmia treatment can achieve better therapeutic effect,which is worthy of further recommendation. 2018 Vol. 25 (11): 111-113 [Abstract] ( 127 ) HTML (34 KB)  PDF  (0 KB)  ( 26 ) 114 Influence of statins intensive lipid-lowering therapy on anxiety and depression of patients with coronary heart disease and psychological disease undergoing PCI ZHANG Wen-ying;XIE Li;ZHENG Yan-lin2 Objective To study the influence of statins intensive lipid-lowering therapy on anxiety and depression of patients with coronary heart disease and psychological disease undergoing PCI.Methods A total of 63 patients with coronary heart disease undergoing PCI with anxiety and depression treated in our hospital from January 2014 to January 2017 were selected as subjects.The level of anxiety and depression,the SAS and SDS scores were compared before and after patients were treated with statins intensive lipid-lowering therapy for eight weeks.Results The patients after statins intensive lipid-lowering therapy were less anxious than before treatment,and the SAS score was higher than before treatment,and the differences were statistically significant(P＜0.05).The degree of depression and SDS score were compared before and after statins intensive lipid-lowering therapy,and the differences were not statistically significant(P＞0.05).Conclusion Statins intensive lipid-lowering therapy may worsen the anxiety condition of patients with heart disease and psychological disease undergoing PCI.For such patients,the statins intensive lipid-lowering therapy should be carried out carefully,and it would be more appropriate to use statins with small dose or moderate intensity to investigate the influence on anxiety and depression. 2018 Vol. 25 (11): 114-116转120 [Abstract] ( 137 ) HTML (36 KB)  PDF  (0 KB)  ( 24 ) 117 A controlled clinical study of Amisulpride and Aripiprazole in treatment of patients with negative symptoms of schizophrenia WEI Li-qun Objective To compare the efficacy and safety between Amisulpride and Aripiprazole in the treatment of patients with negative symptoms of schizophrenia.Methods A total of 80 Patients with negative symptoms of schizophrenia from May to December in 2017 treated in our hospital were selected as the research objects,all the patients were randomly divided into the control group and the study group,40 cases in each group.In the study group,the patients were treated with oral Amisulpride Tablets,and patients in the control group were treated with oral Aripiprazole.Both groups were treated for 8 weeks.The therapeutic effect,the positive and negative syndrome scale (PANSS)scores and adverse reactions were compared between two groups of patients before and after treatment 2,4 and 8 weeks.Results After 8 weeks of treatment,the total efficiency of the study group was 76.92%,and the the total efficiency of the control group was 75.67%,there was no significant difference between the two groups(P＞0.05).After 2 weeks of treatment,the negative factor score of the study group was significantly lower than before treatment and the control group,the differences were statistically significant(P＜0.05),while after 2 weeks of treatment,the negative factor score in the control group was not statistically significant compared with that before treatment(P＞0.05).After 4 weeks of treatment,the scores of negative factors in both groups were significantly lower than before treatment,and the differences were statistically significant(P＜0.05).The incidence of adverse reactions in the study group(41.02%)was lower than that in the control group(54.05%),and the difference was statistically significant(P＜0.05).Conclusion The effect of Amisulprideis equivalent to Aripiprazolein treatment of patients with negative symptoms of schizophrenia,but Amisulpride has faster onset time,less adverse reactions,more safety and better compliance.It is worth popularizing the application. 2018 Vol. 25 (11): 117-120 [Abstract] ( 159 ) HTML (37 KB)  PDF  (0 KB)  ( 30 ) 121 Clinical application value of Calcium Dibutyryladenosine Cyclophosphate combined with Salvianolate in acute myocardial infarction NI Wei-xin;WU Qiang;WANG Chu-lin;LIN Yu-peng;ZHANG Hua-di Objective To explore and analyze the clinical effect of Calcium Dibutyryladenosine Cyclophosphate combined with Salvianolate in acute myocardial infarction.Methods A total of 100 patients with acute myocardial infarction in our hospital from April 2016 to December 2017 were selected as experimental subjects and divided into two groups according to the treatment methods,50 cases in each group.The patients in the control group were treated with conventional treatment,and the patients in the observation group were treated with Calcium Dibutyryladenosine Cyclophosphate combined with Salvianolate.The heart function index level,GRACE coronary heart disease risk score,NIHSS heart function level and adverse event incidence were compared between the two groups.Results The total incidence of adverse events in the observation group(2.00%)was lower than that in the control group(24.00%),and the difference was statistically significant(P＜0.05).After treatment,the proportion of NYHA cardiac function gradeⅠandⅡ in the observation group were significantly higher than those in the control group,while the proportion ofⅢandⅣgrade were lower than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the LVEDD([48.51±2.37]mm)and LVESD([30.53±1.74]mm)in the observation group were lower than those in the control group([55.46±1.61],[42.94±1.52]mm),while the LVEF([56.52±5.74]%)in the observation group was higher than that in the control group([43.37±1.26]%),and the differences were statistically significant(P＜0.05).After treatment,the GRACE coronary heart disease risk score in the observation group was(70.65±6.11)points,which was lower than that in the control group of(76.52±7.52)points,and the difference was statistically significant(P＜0.05).Conclusion The treatment of patients with acute myocardial infarction with Calcium Dibutyryladenosine Cyclophosphate combined Salvianolate is effective and safe. 2018 Vol. 25 (11): 121-123 [Abstract] ( 129 ) HTML (34 KB)  PDF  (0 KB)  ( 27 ) 124 Effect of Montelukast combined with Pulmicort on airway hyper-reactivity in children with Mycoplasma pneumoniae pneumonia ZHANG Hong;REN Yan-ni;DENG Guo-xiong Objective To explore and analyze on the effect of Montelukast combined with Pulmicort on airway hyper-reactivity in children with Mycoplasma pneumoniae pneumonia.Methods From March 2016 to July 2017,a total of 98 cases of children with Mycoplasma pneumoniae pneumonia treated in our hospital were selected as the research objects.The random number table method was used to divide them into reference group and combination group,with 49 cases in each group.The reference group was treated with routine antibiotic treatment and the combination group was treated with routine antibiotics+Montelukast+Pulmicort treatment.The related indexes were compared between the two groups.Results After treatment,the mutation rate of peak expiratory flow(PEF),serum tumor necrosis factor-α (TNF-α)and interleukin-6 (IL-6)levels in the two groups were significantly lower than before treatment,while the mutation rate of PEF,TNF-α and IL-6 in the combination group were lower than those in the reference group,the differences were statistically significant(P＜0.05).The distribution of comprehensive efficacy and the total effective rate in the combination group were significantly different from those in the reference group (P＜0.05).Conclusion On the basis of conventional antibiotics treatment in children with Mycoplasma pneumoniae pneumonia,the Montelukast combined with Pulmicort can improve airway hyper-reactivity,significantly control the inflammatory response and enhance the comprehensive curative effect. 2018 Vol. 25 (11): 124-126 [Abstract] ( 129 ) HTML (33 KB)  PDF  (0 KB)  ( 32 ) 127 Effect analysis of Cyclophosphamide and Prednisone in the treatment of idiopathic interstitial pneumonia TAO Ying-fu Objective To study the clinical efficacy of Cyclophosphamide and Prednisone in the treatment of idiopathic interstitial pneumonia.Methods Sixty patients with idiopathic interstitial pneumonia admitted in our hospital from February 2015 to September 2016 were selected as the study subjects.They were divided into control group and observation group according to the order of treatment time,with 30 cases in each group.In the control group,Prednisone alone was used,while in the observation group,on the basis of the control group,Cyclophosphamide was added.The total effectiveness rate,incidence of adverse reactions,pulmonary function indicators,sleeping quality score and quality of life score before and after treatment were observed and compared between the two groups.Results In the observation group,the total effectiveness rate was 96.67%,which was higher than that in the control group accounting for 70.00%,the incidence of adverse reactions was 6.67%,which was much lower than that in the control group accounting for 30.00%,the pulmonary function indexes (PEF,MVV,FVC)in the observation group were all higher than those in the control group,the differences were statistically significant(P＜0.05).Before treatment,there was no significant difference in the scores of sleeping quality or quality of life between the two groups(P＞0.05).After therapy,the score of sleeping quality in the observation group was lower than that in the control group,and the score of quality of life in the observation group was higher than that in the control group,the differences were statistically significant(P＜0.05).Conclusion The combination of Cyclophosphamide and Prednisone in the treatment of idiopathic interstitial pneumonia is superior to the Prednisone treatment alone,which can effectively improve the pulmonary function indexes and patient′s prognosis with a high clinical value for promotion. 2018 Vol. 25 (11): 127-129 [Abstract] ( 155 ) HTML (33 KB)  PDF  (0 KB)  ( 36 ) 130 Clinical study of Apatinib combined with Compound Kushen Injection in the treatment of malignant tumors ZHONG Hui;ZHONG Zhen-wu;WU Li-fang;ZHONG Yu;LIN Zhou-mei Objective To investigate the clinical effect of Apatinib combined with Compound Kushen Injection in the treatment of malignant tumors.Methods A total of 40 patients with malignant tumors treated in our hospital from March to November in 2017 were selected as subjects.By the random number table method,all patients were evenly divided into two groups,20 cases in each group.In the control group,Apatinib alone was used,while in the research group,Apatinib combined with Compound Kushen Injection were adopted.The clinical effect,adverse reactions and hospitalization expenses and length of stay were observed and compared between the two groups.ResultsThe total effectiveness rate was 90.00%in the research group,which was higher than that in the control group(55.00%),the difference was statistically significant(P＜0.05).The incidence of adverse reactions was 10.00%in the research group,which was lower than that in the control group(40.00%),the difference was statistically significant(P＜0.05).The hospital stay in the research group was(104.19±22.17)d,which was shorter than that of the control group([155.37±32.73]d),the hospitalization expenses in the research group was(20 439.35±10 123.13)yuan,which was less than that of the control group([30 489.17±10 533.71]yuan),the differences were statistically significant(P＜0.05).Conclusion In the treatment of malignant tumors,combination of Apatinib and Compound Kushen Injection can decrease hospitalization expenses,shorten hospital stay,reduce adverse reactions,and achieve a good clinical effect in practicality. 2018 Vol. 25 (11): 130-132 [Abstract] ( 127 ) HTML (33 KB)  PDF  (0 KB)  ( 26 ) 133 Clinical effect observation of Azithromycin combined with Methylprednisolone Sodium Succinate in the treatment of children with refractory Mycoplasma pneumonia ZHU Dong-hui;LIN Dong-yun;TANG Yu-ying;CHEN Xiong-ying;LAI Dong-xue Objective To investigate the clinical effect of Azithromycin combined with Methylprednisolone Sodium Succinate in the treatment of children with refractory Mycoplasma pneumonia.Methods A total of 80 children with refractory Mycoplasma pneumonia treated in our hospital from January 2015 to May 2017 were selected as subjects.According to the different treatment measures,patients were divided into two groups,40 cases in each group.The patients in the control group were treated by Azithromycin alone,and patients in the observation group were treated by Azithromycin combined with Methylprednisolone Sodium Succinate were classified into observation group.The time of wheezing,cough,and sputum expectoration disappeared,the time of fever abating,clinical efficacy,and the levels of C-reactive protein(CRP)and lactate dehydrogenase(LDH)before and after therapy in the two groups were observed and compared.Results In the observation group,the time of wheezing,cough,and sputum expectoration disappeared,and the time of fever abating were all shorter compared with those in the control group with statistical significance(P＜0.05).The levels of CRP and LDH before treatment were not displayed significant differences between the two groups (P＞0.05).After therapy,the levels of CRP and LDH in the two groups were both lower compared with those before treatment,at the same time,the CRP and LDH levels after therapy in the observation group were both lower compared with those in the control group,the differences were statistically significant(P＜0.05).The total clinical effectiveness rate in the observation group was higher than that in the control group with a significant difference (P＜0.05).Conclusion Azithromycin combined with Methylprednisolone Sodium Succinate in the treatment of children with refractory Mycoplasma pneumonia can significantly improve the clinical symptoms and obtain a good clinical effect,which is worthy of clinical application and promotion. 2018 Vol. 25 (11): 133-135转138 [Abstract] ( 157 ) HTML (34 KB)  PDF  (0 KB)  ( 36 ) 136 Therapeutic effect and safety of Triptorelin Acetate in the treatment of central precocious puberty in women WEI Miao-miao Objective To explore and analyze the clinical efficacy and safety of Triptorelin Acetate in the treatment of central precocious puberty in women.Methods A total of 90 girls with central precocious puberty treated in our outpatient clinics and inpatient wards from October 2014 to August 2016 were selected as the study subjects.According to different treatment methods,the patients were evenly divided into two groups,45 cases in each group.In experimental group,patients were treated with Triptorelin Acetate,one year was for a course of treatment.In control group,patients were not provided with any intervention.After one course of treatment,the height,weight,body mass index(BMI)and predicted height before and after treatment were observed,recorded and calculated.The hormone levels such as serum estradiol(E2),follicle stimulating hormone(FSH)and luteinising hormone(LH)before and after therapy were determined in order to evaluate the therapeutic efficacy.ResultsAfter one course of treatment,the height,weight,predicted height,bone age of the two groups were significantly higher than before treatment,the differences were statistically significant(P＜0.05).The the height,weight and predicted height in the experimental group were much higher than those of the control group,while the bone age of the experimental group were significantly lower compared with those in the control group,the differences were statistically significant(P＜0.05).The serum levels of E2,FSH and LH after therapy in the two groups were significantly lower than those before treatment with statistical significance (P＜0.05).The levels of E2,FSH and LH in the experimental group were significantly lower than in the control group,the differences were statistically significant(P＜0.05).The incidence of adverse reactions in the experimental group was significantly lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion The effect of Triptorelin Acetate in the treatment of female central precocious puberty is good and worthy of clinical promotion. 2018 Vol. 25 (11): 136-138 [Abstract] ( 141 ) HTML (33 KB)  PDF  (0 KB)  ( 27 ) 139 Effect of Montelukast Sodium combined with Tolobuterol Patch in the treatment of children with chronic cough and its effect on serum IgE level WANG Shao-yi;GUO Wei-zhong;HUANG Chan-juan Objectives To investigate the effect of Montelukast Sodium combined with Tolobuterol Patch in the treatment of children with chronic cough and the effect on serum IgE level.Methods A total of 70 children with chronic cough treated in our hospital from January 2015 to March 2017 were selected as subjects.They were randomly divided into experimental group and control group by random number table method,with 35 cases in each group.The control group was treated with Tolobuterol Patch.The children in the experimental group were treated with Montelukast Sodium on the basis of the control group,and the two groups were treated for 4 weeks.The changes of serum IgE level and the curative effect were compared between the two groups.Results The total effective rate of the experimental group was 91.43%,which was significantly higher than that of the control group(71.43%),the difference between the two groups was statistically significant(P＜0.05).But there was no significant difference in serum IgE level between the two groups before treatment(P＞0.05).After treatment,the serum IgE level of both groups were significantly lower than those before treatment,and the serum IgE level of the children in the experimental group was significantly lower than that in the control group,the differences were statistically significant(P＜0.05).The time of relieving and disappearing cough in the experimental group were significantly shorter than those in the control group,and the differences between the two groups were statistically significant(P＜0.05).Conclusion Based on the application of Tolobuterol Patch,the combined use of Montelukast Sodium in the treatment of children with chronic cough can significantly improve the serum level of IgE,has a more significant effect,also helps to alleviate cough remission time and vanishing time,suitable for clinical use. 2018 Vol. 25 (11): 139-141 [Abstract] ( 127 ) HTML (31 KB)  PDF  (0 KB)  ( 31 ) 142 Effect observation of Xinjia Weiling Decoction combined with Montmorillonite Powder in the treatment of senile chronic diarrhea WANG Yu-min;WANG Zun-gai Objective To investigate the effect of Xinjia Weiling Decoction combined with Montmorillonite Powder in the treatment of senile chronic diarrhea.MethodsFrom March 2016 to August 2017,80 elderly patients with chronic diarrhea(spleen-dampness type)treated in our hospital were included in the study and grouped according to the random number table.40 cases in the control group were given Montmorillonite Powder alone for treatment,40 cases in the observation group were orally added Xinjia Weiling Deoction.A course of treatment lasted for 4 weeks.The total symptom score and the improvement of gastrointestinal hormones were compared between the two groups.The clinical efficacy were compared between the two groups.Results After treatment,the score of abdominal pain,stool characteristics,frequency of diarrhea,bloating and other symptoms in the observation group were lower than those in the control group,and the difference was statistically significant(P＜0.05).After treatment,gastrointestinal peptide(VIP)level in the observation group was lower than that in the control group,and neuropeptide (NPY)level was higher than that in the control group,and the difference was statistically significant(P＜0.05).The total effective rate in the observation group was 95.00%,which was higher than that in the control group(77.50%),and the difference was statistically significant(P＜0.05).Conclusion Xinjia Weiling Decoction combined with Montmorillonite Powder in the treatment of elderly chronic diarrhea has a significant effect,which can better improve gastrointestinal hormones,and is worthy of promotion. 2018 Vol. 25 (11): 142-144 [Abstract] ( 137 ) HTML (33 KB)  PDF  (0 KB)  ( 28 ) 145 ClinicaleffectofZhenwu Decoction combined with intraperitoneal chemotherapy in the treatment of carcinomatous ascites of spleen and kidney yang deficiency type LUO Jia-hua;LIU Zhen-hai;LI Zeng-hui Objective To investigate the effect of Zhenwu Decoction combined with intraperitoneal chemotherapy in the treatment of carcinomatous ascites of spleen and kidney yang deficiency type.Methods The clinical data of 50 patients with carcinomatous ascites identified as spleen and kidney yang deficiency type treated in our hospital from January 2015 to January 2017 were analyzed.According to the different treatment methods,20 patients in the control group were treated with Cisplatin and Fluorouracil chemotherapy and the rest was classified into the observation group given Cisplatin and Fluorouracil chemotherapy plusing Zhenwu Decoction.T cell subsets,NK cells,clinical efficacy and the incidence of adverse reactions in the two groups were observed.Results The amount of CD4+,CD3+,CD8+,CD4+/CD8+and NK cells,and total clinical remission rate in the observation group were all higher than those in the control group and the incidence of adverse reactions such as hematological toxicity,gastrointestinal reaction,liver function damage,renal function damage,and mucosal ulcer was lower than that in the control group,with a statistical difference(P＜0.05).Conclusion Zhenwu Decoction combined with intraperitoneal chemotherapy in the treatment of carcinomatous ascites of spleenkidney yang deficiency type can improve the organismic immune function with a high remission rate and few adverse reactions,which is worthy of clinical application and promotion. 2018 Vol. 25 (11): 145-147 [Abstract] ( 134 ) HTML (34 KB)  PDF  (0 KB)  ( 22 ) 148 Effect of traditional Chinese medicine combined with Thyroid Hormone Tablets preventing postoperative recurrence of nodular goiter WEN Chun-ya Objective To study the effect of traditional Chinese medicine combined with Thyroid Hormone Tablets preventing postoperative recurrence of nodular goiter.Methods Ninety patients with nodular goiter treated in our hospital from March 2014 to March 2016 were selected as the research object,and they were the divided into control group(45 cases)and observation group (45 cases)according to computer random grouping method.The control group was treated with Thyroxine Tablets,while the observation group was treated with Thyroxine Tablets plusing traditional Chinese medicine.The recurrence and treatment effect between the two groups were compared.Results The recurrence rate of patients in the observation group was 6.67%in half a year,which was obviously lower than that of the control group(24.44%)(P＜0.05),and the total clinical effective rate was 93.33%in the observation group,which was obviously higher than that of the control group(75.56%)(P＜0.05).ConclusionTraditional Chinese medicine combined with Thyroid Hormone Tablets can better prevent postoperative recurrence of nodular goiter. 2018 Vol. 25 (11): 148-150 [Abstract] ( 157 ) HTML (32 KB)  PDF  (0 KB)  ( 29 ) 151 Clinical effect of Kangfu Xiaoyan Suppository combined with antibiotics in the treatment of chronic pelvic inflammation WANG Xian-min;ZHOU Hai-jun Objective To explore the clinical effect of Kangfu Xiaoyan Suppository combined with antibiotics in the treatment of chronic pelvic inflammation.MethodsNinety-three patients with chronic pelvic inflammatory treated in our hospital from April to December 2016 were selected as the study subjects,and they were divided into the control group(46 cases)and the observation group(47 cases)according to the random number table method.The control group was treated with a single antibiotics,and the observation group was treated with Kangfu Xiaoyan Suppository combined with antibiotics.The total effective rate,effective time,medication time,the incidence of adverse reaction and recurrence rate were compared between the two groups.Results The total effective rate of observation group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).The effective time and medication time in patients of the observation group were shorter than those of the control group,and the differences were statistically significant(P＜0.05).The incidence of adverse reaction of the observation group was slightly higher than that of the control group,but the difference was not statistically significant(P＞0.05).The recurrence rate of the observation group was significantly lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion The effect of Kangfu Xiaoyan Suppository combined with antibiotics in the treatment of gynecologic pelvic inflammatory disease is better than that of single antibiotics treatment,which can obviously improve the clinical symptoms of the patients and it is recommend to use. 2018 Vol. 25 (11): 151-153 [Abstract] ( 146 ) HTML (32 KB)  PDF  (0 KB)  ( 34 ) 154 Analysis on epidemiological characteristics of hand-foot-and-mouth disease in 2013-2017 in Zhuhai ZHOU Chuan-en;XIONG Shou-gui;LI De-yun Objective To understand the epidemiological characteristic of hand-foot-and-mouth disease (HFMD)in Zhuhai and to provide scientific evidence for prevention and control strategies.Methods Based on the incidence of HFMD in 2013-2017 in Zhuhai,its epidemiological characteristic and pathogenic monitoring were analyzed.ResultsA total of 69 656 cases of HFMD were reported in 2013-2017 in Zhuhai,and the annual average incidence rate was 860.3/100 000,of which the incidence rate(984.2/100 000)in males was significantly higher than that in females(726.1/100 000),and the ratio of males to females was 1.4∶1(P＜0.05).The incidence of children in 0-4 years old was significantly higher than that in other age groups(P＜0.05),the incidence ratio of the groups at 0-4 years old,＞4-9 years old and ＞9 years old were 87.0%,11.0%and 2.0%,respectively.Different professional distribution of scattered children in five years the proportion(69.5%)was significantly higher than that of children at kindergartens(26.0%),students(3.8%),and others(0.8%),showed that occur among mainly scattered children (P＜0.05).In 2013-2017,the annual incidence rate of HFMD in Zhuhai decreased year by year(P＜0.05),which was 852.8/100 000,942.1/100 000,900.3/100 000,747.0/100 000 and 861.7/100 000,respectively,and the annual incidence peak appeared from May to July.The average incidence of five years in Xiangzhou district was significantly higher than that of Doumen and Jinwan districts(P＜0.05),their average incidence was 934.0/100 000,756.7/100 000 and 764.0/100,000,respectively.The result from pathogenic monitoring showed that the enterovirus EV71 and Cox A16 infections accounted for 33.4%and 21.6%respectively.Conclusion The incidence of HFMD in Zhuhai shows obvious characteristics of season,age and region,therefore,prevention propaganda work should be carried out according to seasonal change and climate characteristics,and more attentions should be paid to the preventive health care on children under 6 years old at communities and kindergartens. 2018 Vol. 25 (11): 154-157 [Abstract] ( 141 ) HTML (40 KB)  PDF  (0 KB)  ( 33 ) 158 Allergen spectrum analysis of allergic skin diseases in Southern Jiangxi Province PEI Xian-feng Objective To study the allergen spectrum of allergic skin diseases in Southern Jiangxi Province and to identify the common allergens of allergic skin diseases in this area,and to provide evidence for the prevention and treatment of allergic skin diseases in Southern Jiangxi Province.Methods A total of 1126 cases of allergic dermatosis in Southern Jiangxi Province from October 2015 to October 2017 were enrolled in this study.According to different age groups,they were divided into the children group (≤14 years old,n=316),the adolescent group (＞14-34 years old,n=529)and the middle-aged and elderly group (＞34 years old,n=281).Western blotting was used to detect the specific IgE from serum in all the patients to identify the allergens and analyze the positivity rate of allergen different age groups.ResultsThe home dust mite/dermatophagoides farina and dwarf ragweed/artemisia were common in the inhaled allergens,and the positivity rate was higher than that other species (P＜0.05).In food intake group,allergens such as fish,shrimp,crab and cashew nuts,peanut,and soybean were the most common with a higher positivity rate than that other species(P＜0.05).The positivity rates of single species in the children group,the adolescent group and the middle-aged and elderly group were all higher than those of two and above species(P＜0.05).There was no difference in the positivity rates of inhalation and ingestion of allergens between different age groups(P＞0.05).In the middle-aged and elderly group,the positivity rates of single species and two species and more were significantly lower than those in the children and the adolescent groups(P＜0.05).The positivity rates of allergen inhalation and ingestion were both lower than those in the children and adolescent groups(P＜0.05).Conclusion Inhaled allergens that caused allergic skin diseases in Southern Jiangxi Province mainly are home dust mite/dermatophagoides farina and dwarf ragweed/artemisia,and for in-feed allergens,fish,shrimp,crab and cashew nuts,peanut,and soybean take the priority.The younger the patient is,the more prone the allergic skin disease occurs,therefore,expansion to detect the allergen species such as seafood and nuts in Southern Jiangxi Province and active prevention on younger children can further reduce the incidence of allergic skin diseases in this area. 2018 Vol. 25 (11): 158-160 [Abstract] ( 131 ) HTML (36 KB)  PDF  (0 KB)  ( 30 ) 161 Application of PDCA theory in operating room and supply room integration management ZHOU Can;PENG Yan-mei;YI Hong-yan;DENG Su-juan Objective To explore the application effect of PDCA theory in operating room and supply room integration(OSI)management.Methods 435 surgical instruments and 112 surgeons without PDCA theory in OSI management in our hospital from July to October 2016 were selected as the traditional group.542 surgical instruments and 123 surgeons with PDCA theory in OSI management in our hospital from July to October 2017 were selected as the PDCA group.The situation of the surgical instruments cleaning,packaging,losing,sterilization and surgeons′satisfaction degree for the instruments were compared between the two groups.Results After OSI management based on PDCA,the pass rate of surgical instruments cleaning,packaging,sterilization and surgeons′satisfaction degree of PDCA group were higher than those of traditional group,and the losing rate was lower than the traditional group (P＜0.05).Conclusion The PDCA theory plays a positive role in OSI management and helps improve device management and surgeons′satisfaction degree for the surgical instruments. 2018 Vol. 25 (11): 161-163 [Abstract] ( 142 ) HTML (32 KB)  PDF  (0 KB)  ( 30 ) 164 Analysis of the influence of joint tracking management model on self management ability of patients with depression MO Yang-hua;HE Ru-bing;LI Yan-hong Objective To discuss the influence of joint tracking management model on self management ability of patients with depression.Methods From March 2015 to March 2017,80 patients with depression treated in our hospital were selected and they were randomly divided into experimental group(n=40)and control group(n=40).The patients in the control group were given with routine management mode,and the patients in the observation group were given with joint tracking management mode on the basis of the control group.SCSQ score,SDS score,and SF-36 score of the two groups were observed after intervention.Results Before intervention,there was no significant difference in SCSQ positive score and negative score in patients between the two groups(P＞0.05).After intervention,the positive score of SCSQ in the experimental group was higher than that in the control group,and the negative score was lower than that in the control group (P＜0.05).There was no significant difference in SDS score between the two groups before intervention (P＞0.05).SDS score of the experimental group was lower than that of the control group after intervention(P＜0.05).After intervention,the score of PF,SF,BP,MH factor in the experimental group were significantly higher than those in the control group(P＜0.05).There were no significant differences of the score of RP,RE,VT,GH factor between the two groups(P＞0.05).Conclusion The joint tracking management model is effective in improving the self-management ability of depressive patients and is worth popularizing clinically. 2018 Vol. 25 (11): 164-167 [Abstract] ( 156 ) HTML (39 KB)  PDF  (0 KB)  ( 33 ) 168 Application effect of continuous quality improvement management in patients given CT enhanced scan CHEN Rong-ping;LUO Fang Objective To investigate the application effect of continuous quality improvement(CQI)management in patients given CT enhanced scan.Methods From April 2015 to April 2016,86 patients given CT enhanced scan having no CQI management treated in our hospital were selected as the control group,while 86 patients patients given CT enhanced scan having CQI management treated in our hospital from September 2016 to September 2017 were selected as the observation group.The incidence of extravasation and the improvement effect of nurses′nursing skills were compared between the two groups.Results The incidence of extravasation in the observation group was significantly lower than that in the control group,with significant difference between the two groups (P＜0.05).The mastery rate of nursing knowledge,success rate of puncture,awareness rate of notices for enhanced scan and satisfaction degree of patients in the observation group were significantly higher than those in the control group,and there was a statistical difference(P＜0.05).Conclusion The method of CQI can effectively prevent the CT enhanced extravasation and improve nursing skills and satisfaction degree of patients.It deserves clinical application and further promotion. 2018 Vol. 25 (11): 168-170 [Abstract] ( 116 ) HTML (30 KB)  PDF  (0 KB)  ( 31 ) 171 Application effect of rapid rehabilitation surgical mode in patients performed with cholecystectomy CHEN Hong-bing;LI Jian;WANG Jian;LI Xue-yuan;ZHU Shu-lian Objective To investigate the application effect and analysis of rapid rehabilitation surgical mode in patients performed with cholecystectomy.Methods A total of 90 patients with cholecystectomy from January 2015 to December 2017 were selected and divided into control group and observation group according to the patient′s visit time(bimonthly,single month),45 cases in each group.The study group received fast-track surgery(no gastric tube placement before operation,health education with patients and their families,and oral feeding at early stage after operation),while the control group received routine surgery(gastric tube placement for anal exhaust after operation).The operation related indexes of the two groups,the level of C-reactive protein before and after treatment,the healing of the wound after the operation,the postoperative adverse reaction and the postoperative pain were observed and compared.Results The postoperative anal exhaust time,postoperative defecation time,postoperative eating time,postoperative ambulation time and postoperative hospital stay in the study group were shorter than those in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in C-reactive protein level between the two groups before operation.C-reactive protein levels in the study group were significantly lower than those in the control group,and the differences were statistically significant(P＜0.05).The excellent rate of wound healing in the study group was significantly higher than that in the control group (χ2=7.2827,P=0.0070).The adverse reaction rate in the study group was lower than that in the control group,and the difference was statistically significant （χ2=6.4286，P=0.0112）.The incidence of postoperative pain in the study group was significantly lower than that in the control group,and the difference was statistically significant（χ2=7.7885，P=0.0053）.Conclusion The application of rapid rehabilitation surgical mode in patients undergoing cholecystectomy obtain a significant effect and is of great value. 2018 Vol. 25 (11): 171-173转177 [Abstract] ( 149 ) HTML (37 KB)  PDF  (0 KB)  ( 22 ) 174 The value of continuous nursing in patients with dacryocystorhinostomy under nasal endoscopy ZOU Li-na;HUANG Yueyan Objective To explore the value of continuous nursing in patients with dacryocystorhinostomy under nasal endoscopy.Methods From January 2014 to December 2016,120 patients with dacryocystorhinostomy under nasal endoscopy were selected and divided into control group and observation group by random number table method,with 60 cases in each group.The observation group was treated with continuous nursing intervention,while the control group was treated with routine nursing intervention.The total satisfaction,total compliance rate,the disappearance time of pyorrhea symptoms,the disappearance time of epiphora symptoms,the obstruction rate of lacrimal passage irrigation and the score of quality of life scale were compared between the two groups.Results The total satisfaction of the patients in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The total compliance rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).In the observation group,the disappearance time of epiphora and pyorrhea was shorter than that in the control group,and the rate of lacrimal irrigation obstruction was lower than that in the control group,the differences were statistically significant(P＜0.05).The scores of quality of life in the observation group were higher than those in the control group,and the difference was statistically significant(P＜0.05).Conclusion The effect of continuous nursing intervention on endoscopic dacryocystorhinostomy is significant. 2018 Vol. 25 (11): 174-177 [Abstract] ( 138 ) HTML (37 KB)  PDF  (0 KB)  ( 29 ) 178 Research on the recovery of postpartum pelvic floor function after using early postpartum pelvic floor rehabilitation training led in community health service center XU Ju-fang;HONG Jia-ying;LUO Qiang-huan Objective To explore the effect of early postpartum pelvic floor rehabilitation training led in community health service center on the recovery of postpartum pelvic floor function.Methods A total of 152 cases of pregnant women admitted to our hospital from January 2016 to February 2017 were divided into routine group and study group according to different rehabilitation training methods,76 cases in each group.Postpartum health education was carried out in the conventional group,and pelvic floor rehabilitation training was carried out in the study group based on the conventional group.The pelvic floor muscle strength recovery,urinary incontinence simplified score scale (ICIQ-SF),anxiety scale(SAS),depression scale(SDS),quality of life score,total urine volume(TV),total urine volume(TOV)and total urine leakage number(LT)were compared between the two groups.Results In the study group the proprotion of muscle strength lavel 5 was significantly higher than that of the conventional group (P＜0.05),and the strength porprotion of level 1 of the maternal basin was significantly lower than that of the conventional group(P＜0.05).ICIQ-SF score in the study group was significantly lower than that in the control group(P＜0.05).The scores of SAS and SDS in the study group were significantly lower than those in the control group(P＜0.05).The quality of life in the study group was significantly higher than that in the routine group(P＜0.05).There was no statistically significant difference between the two groups of maternal TV indicators(P＞0.05),the study group of maternal TOV and IT indicators were significantly lower than the conventional group,the differences were statistically significant(P＜0.05).Conclusion Early postpartum pelvic floor rehabilitation training can promote the recovery of postpartum pelvic floor function,strengthen the postpartum pelvic floor muscle,eliminate negative emotions in the process of maternal rehabilitation training,improve the urinary incontinence and quality of life,which has clinical significance and application value. 2018 Vol. 25 (11): 178-181 [Abstract] ( 121 ) HTML (39 KB)  PDF  (0 KB)  ( 30 ) 182 Application ofevidence-based nursing in premature rupture of membranes XIONG Jin-mei;GUI Shao-zhen Objective To study the clinical effect of the nursing of the parturient with premature rupture of the membranes during the treatment.Methods From March 2015 to March 2017,82 cases of premature rupture of membranes were randomly divided into control group and observation group,41 cases in each group.The control group received routine obstetric care.Evidence-based nursing intervention was carried out in the observation group.The number of cases of postpartum infection,satisfaction of nursing service during the treatment of premature rupture of membranes,postpartum hemorrhage,postpartum hospital treatment time were compared between the two groups.Results The incidence of postpartum infection was14.6%(6 cases)in the observation group,less than 51.2% (21 cases)in the control group,the difference was statistically significant(P＜0.05).The satisfaction degree of nursing service in observation group was higher than that in control group (P＜0.05).The amount of postpartum hemorrhage in the observation group was lower than that in the control group,and the duration of postpartum hospitalization was shorter than that in the control group(P＜0.05).Conclusion The implementation of the inquiry nursing during the treatment period of the premature rupture of membranes can ensure the safety of the mother and baby in the perinatal stage,shorten the time of hospitalization and improve the satisfaction of the pregnant women to the nursing service. 2018 Vol. 25 (11): 182-184 [Abstract] ( 147 ) HTML (32 KB)  PDF  (0 KB)  ( 32 ) 185 Influence of health education on the nursing in patients with gestational diabetes mellitus ZHANG Xiao-yan Objective To investigate the effect of the health education on the compliance behavior and the maternal and infant outcomes in patients with gestational diabetes mellitus.Methods A total of 89 patients with gestational diabetes mellitus treated in our hospital from July 2015 to April 2017 were randomly divided into control group (n=44)and observation group(n=45).The control group received routine nursing intervention and health publicity and education based on routine nursing.The scores of compliance behavior(psychological regulation,regular exercise,reasonable diet,blood glucose monitoring,compliance with medical drugs,regular prenatal examination)and the changes of blood glucose levels(fasting blood glucose,2 h blood glucose after meal)before and after intervention were compared between the two groups.The adverse maternal and infant outcomes and nursing satisfaction were also counted.Results The scores of compliance behavior (psychological regulation,regular exercise,reasonable diet,blood glucose monitoring,compliance with medical drugs and regular prenatal examination)in the observation group were higher than those in the control group,the differences were statistically significant(P＜0.05).After intervention,fasting blood glucose and 2 h postprandial blood glucose in the observation group were significantly lower than those in the control group,the differences were statistically significant(P＜0.05).The incidence of adverse maternal and infant outcomes in the observation group were lower than that in the control group,the differences were statistically significant(P＜0.05).The nursing satisfaction of the observation group was higher than that of the control grou,the difference was statistically significant(P＜0.05).Conclusion The application of health education in patients with gestational diabetes mellitus has a remarkable effect on blood sugar control.It is helpful to improve the patients′compliance behavior,and reduce the incidence of adverse maternal and infant outcomes.Besides,it has high nursing satisfaction. 2018 Vol. 25 (11): 185-188 [Abstract] ( 166 ) HTML (39 KB)  PDF  (0 KB)  ( 31 ) 189 Factors Analysis and Countermeasures of Nursing Adverse Events in Nursing Students YUAN Jing At present,the relationship between doctors and patients in our country is increasingly tense.At the same time,the problems of nurses and patients are also becoming more and more prominent,further aggravating the contradiction between doctors and patients.However,in healthcare,nurse-patient relationship is crucial and at the heart of relationships in nursing practice.Among nurse-patient problems,the nursing adverse events of practical nursing students are frequent,which have a significant impact on nurse-patient relationship.Therefore,this article focuses on in-depth analysis of the factors that affect nursing internship nursing students adverse events,and put forward relevant solutions. 2018 Vol. 25 (11): 189-191 [Abstract] ( 158 ) HTML (32 KB)  PDF  (0 KB)  ( 35 ) 192 On the Effects of the Joint Implementation of Ventilator Pipeline Humidification and Mouth Cavity Nursing in the Prevention of Ventilator-related Pneumonia HUANG Li-juan;WU Yu-ting;LIU Ai-xiu;XIN Yan-hong;WU Min Objective To investigate the effect of ventilator-associated pneumonia(VAP)prevention in ICU by ventilator tube humidification combined with oral care.Methods A total of 112 patients with mechanical ventilation admitted to our hospital from September 2014 to February 2016 were selected as the research objects,and randomly divided into control group and study group,with 56 cases in each group.The control group was given routine nursing plan,the study group was given ventilator tube humidification combined with oral care at the same time of routine nursing.The duration of mechanical ventilation,ICU stay,average hospital stay and the incidence of VAP were compared between the two groups.Results The duration of mechanical ventilation,ICU stay and average hospital stay in the study group were shorter than those in the control group (P＜0.05).VAP occurred in 7 patients (12.50%)in the control group.VAP occurred in 1 patient(1.79%)in the study group.The incidence of VAP in the study group was significantly lower than that in the control group(χ2=4.846,P=0.028).Conclusion The joint implementation of ventilator pipeline humidification and mouth cavity nursing for patients in ICU can effectively reduce the occurrence of VAP,shorten the time of mechanical ventilation,ICU staying and hospitalization.It is high clinically valuable and is worthy of wide application. 2018 Vol. 25 (11): 192-194 [Abstract] ( 140 ) HTML (32 KB)  PDF  (0 KB)  ( 26 ) 195 Effects of acupoint injection and moxibustion intreatment for postoperative intestinal peristalsis recovery YE Xiao-mei;LI Min-wen;PANG Qiong Objective To explore the effects of acupoint injection and moxibustion intreatment for postoperative intestinal peristalsis recovery.Methods A total of 90 patients underwent abdominal surgery in our hospital from January 2015 to December 2016 were randomly divided into observation group(n=46)and control group(n=44).The control group received routine nursing measures after abdominal operation.The observation group was treated by acupoint injection combined with moxibustion in addition to routine nursing measures after abdominal operation.The curative effect,recovery time of intestinal peristalsis and first anal exhaust time were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).The recovery time of intestinal peristalsis and the first anal exhaust time in the observation group were shorter than those in the control group,and the differences were statistically significant(P＜0.05).Conclusions The acupoint injection and moxibustion intreatment can effectively promote postoperative intestinal peristalsis recovery. 2018 Vol. 25 (11): 195-封三 [Abstract] ( 131 ) HTML (39 KB)  PDF  (0 KB)  ( 23 )

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