环磷酰胺与泼尼松联合治疗特发性间质性肺炎的效果分析

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Abstract Objective To study the clinical efficacy of Cyclophosphamide and Prednisone in the treatment of idiopathic interstitial pneumonia.Methods Sixty patients with idiopathic interstitial pneumonia admitted in our hospital from February 2015 to September 2016 were selected as the study subjects.They were divided into control group and observation group according to the order of treatment time,with 30 cases in each group.In the control group,Prednisone alone was used,while in the observation group,on the basis of the control group,Cyclophosphamide was added.The total effectiveness rate,incidence of adverse reactions,pulmonary function indicators,sleeping quality score and quality of life score before and after treatment were observed and compared between the two groups.Results In the observation group,the total effectiveness rate was 96.67%,which was higher than that in the control group accounting for 70.00%,the incidence of adverse reactions was 6.67%,which was much lower than that in the control group accounting for 30.00%,the pulmonary function indexes (PEF,MVV,FVC)in the observation group were all higher than those in the control group,the differences were statistically significant(P＜0.05).Before treatment,there was no significant difference in the scores of sleeping quality or quality of life between the two groups(P＞0.05).After therapy,the score of sleeping quality in the observation group was lower than that in the control group,and the score of quality of life in the observation group was higher than that in the control group,the differences were statistically significant(P＜0.05).Conclusion The combination of Cyclophosphamide and Prednisone in the treatment of idiopathic interstitial pneumonia is superior to the Prednisone treatment alone,which can effectively improve the pulmonary function indexes and patient′s prognosis with a high clinical value for promotion.

Key words： Cyclophosphamide Prednisone Idiopathic interstitial pneumonia Adverse reaction Pulmonary function

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TAO Ying-fu. Effect analysis of Cyclophosphamide and Prednisone in the treatment of idiopathic interstitial pneumonia[J]. 中国当代医药, 2018, 25(11): 127-129.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I11/127

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