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| Influence of parathyroidectomy in the cognitive function and quality of life for uremia patients with secondary hyperparathyroidism |
| GUO Huan-kai YANG Xiao-ran LIANG Jin-yun LIU Cai-ling XU Qing-dong |
| Department of Nephrology,Jiangmen Central Hospital,Guangdong Province,Jiangmen 529000,China |
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Abstract Objective To investigate the influence of total parathyroidectomy combined with autologous transplantation in the cognitive function and quality of life for uremia patients with secondary hyperparathyroidism(SHPT).Methods A total of 58 SHPT patients with uremia who were admitted to our hospital from January 2015 to October 2016 were selected as the study subjects.They were with the past history of total resection of the parathyroid gland.The improvement of cognitive function and quality of life in the patients before the surgery and one year after the surgery were statistically analyzed.Results Blood parathyroid hormone (iPTH),serum calcium,serum phosphorus,and alkaline phosphatase (ALP)were lower than those before surgery on the 1st,3rd,7th,14th,and 21stdays after surgery for parathyroidectomy,the level of hemoglobin(Hb)was higher than that before surgery,and the difference was statistically significant(P＜0.05);the MMSE score was(15.02±1.35)points at one year after the surgery,which was higher than that of(7.54±0.21)points before the surgery,and the difference was statistically significant(P＜0.05);at 1 year after surgery,the total score of SF-36 was significantly higher than that before surgery,and the difference was statistically significant(P＜0.05).The PF,RP,BP,and GH were significantly higher than those before the surgery,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in VT,SF,RE,and MH before and after the surgery (P＞0.05).The OHR score at one year after the surgery was significantly higher than that before the surgery,and the difference was statistically significant(P＜0.05).The SPL,EKD,and Sleep scores were higher than those before the surgery,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in the other items before and after surgery(P＞0.05).Conclusion Parathyroidectomy can improve the cognitive ability in the patients with uremia complicated with secondary hyperparathyroidism and effectively improve their quality of life,which is worthy of clinical promotion.
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