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Quick Search     Adv Search 2021 Vol. 28, No. 12 Published: 2021-04-28   4 Research on the correlation between serum level of NT-proBNP and cardiac function and ventricular remodeling in elderly patients with chronic congestive heart failure NA Kun；ZHANG Li-shi； XUE Xin； WANG Rui-hai； BAI Dong； HU Hua-gang Objective To observe the efficacy of the effective part formula of garlic (Y means garlic oil, Z means garlic saponin,D means garlic polysaccharide)on the life extension rate and anti-inflammatory of inoculated S180 mice. Methods In experiment 1, 80 male Kunming mice were divided into model group, solvent group, Cyclophosphamide group,garlic oil group, the test effective components high dose (Y+Z+D) group, secondary high dose (Y+Z+D) group, medium dose (Y+Z+D) group and low dose (Y+Z+D) group according to the random number table method, with 10 mice in each group. The survival time and life extension rate of each mouse in each group were observed and recorded after 10 days of administration of the corresponding drugs. In experiment 2, 72 Kunming mice, including 36 male mice and 36 female mice, were divided into model group, Aspirin group, high dose garlic YZD group, secondary high dose garlic YZD group, medium dose garlic YZD group and low dose garlic YZD group, with 12 mice in each group (half male and half male). The mice of above groups were given corresponding test drugs once a day for 7 days. Two hours after the last administration, the mice were killed. Each ear was cut and weighed, and the swelling degree and swelling inhibition rate were calculated. Results The results of experiment 1 showed that the survival time of animals in the high dose (Y+Z+D)group and garlic oil group was statistically significant compared with the model group (P＜0.05). The survival time of animals in the high dose (Y+Z+D) group and garlic oil group was longer than that in the other groups, and the difference was statistically significant (P＜0.05). The life extension rate of the high dose (Y+Z+D) group and the garlic oil group was also higher than that of the other groups. The results of experiment 2 showed that high dose garlic YZD has a certain anti-inflammatory effect. Conclusion The effective part formula of garlic (high dose of Y+Z+D) has certain anti-tumor and anti-inflammatory effect. 2021 Vol. 28 (12): 4-007 [Abstract] ( 52 ) HTML (39 KB)  PDF  (0 KB)  ( 8 ) 8 Research on the correlation between serum level of NT-proBNP and cardiac function and ventricular remodeling in elderly patients with chronic congestive heart failure ZHANG Bo-cheng；ZHANG Xiao-wen；GONG Yan-qing；ZHANG Bao-jun；HU Shao-yu Objective To investigate the correlation between serum level of N-terminal pro B type natriuretic peptide(NT-proBNP) and cardiac function and ventricular remodeling in elderly patients with chronic congestive heart failure(CHF). Methods A total of 80 elderly patients (≥65 years old) with CHF who were hospitalized in Xinyu Traditional Chinese Medicine Hospital from January 2018 to December 2020 were selected as the research objects. Serum levels of NT-proBNP, left ventricular end diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI) and interventricular septal thickness (IVST) were compared in patients with different New York Heart Association (NYHA) classification. Spearman rank correlation was used to analyze the correlation between serum levels of NT-proBNP and NYHA classification, meanwhile Pearson correlation was used to analyze the correlation between serum levels of NT-proBNP and LVEDD, LVEF, LVMI and IVST. Results The serum NT-proBNP level,LVEDD, LVMI and IVST of patients in cardiac function group Ⅳwere higher than those in cardiac function group Ⅲ,cardiac function group Ⅱand cardiac function group Ⅰ,while LVEF was lower than that in cardiac function group Ⅲ, cardiac function group Ⅱand cardiac function group Ⅰ, the differences were statistically significant (P＜0.05). The serum NT-proBNP level, LVEDD, LVMI and IVST of patients in cardiac function group Ⅲwere higher than those in cardiac function group Ⅱand cardiac function groupⅠ, while LVEF was lower than that in cardiac function group Ⅱand cardiac function group Ⅰ, the differences were statistically significant (P＜0.05). The serum NT-proBNP level, LVEDD, LVMI and IVST of patients in cardiac function group Ⅱwere higher than those in cardiac function group Ⅰ, while LVEF was lower than that in cardiac function group Ⅰ, the differences were statistically significant (P＜0.05). Pearson correlation analysis showed that serum NTproBNP levels were positively correlated with LVEDD, LVMI and IVST in CHF patients (r=0.603, 0.310, 0.295, P＜0.05), and negatively correlated with LVEF (r=-0.612, P＜0.05). Spearman rank correlation analysis showed that serum NT-proBNP level in CHF patients was positively correlated with NYHA classification (r=0.553, P＜0.05). Conclusion Serum level of NT-proBNP is significantly correlated with cardiac function and ventricular remodeling in elderly patients with CHF, and can be used as an important reference index for evaluating the cardiac function, myocardial remodeling and treatment of patients with CHF. 2021 Vol. 28 (12): 8-011 [Abstract] ( 49 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 12 Cross-sectional study on the relationship between passive smoking and diabetes, pre-diabetes in natural population DONG Yong-hai；YAN Wei；HU Ji-long； CHEN Yi-ying； LIU Jie； XU Yan； SHI Qi； LIU Yun Objective To explore the relationship between passive smoking and diabetes, pre-diabetes in natural population. Methods A total of 6000 residents from chronic disease surveillance in Jiangxi province were selected by multi-stage sampling from May 2013 to December 2015, and the Surveillance Questionnaire for Chronic Diseases and Their Risk Factors in China designed by Chinese Center for Disease Control and Prevention was used for questionnaire survey and laboratory examination. According to the results of fasting blood glucose, the subjects were divided into three groups: diabetic group (426 cases, fasting blood glucose ≥7.0 mmol/L), pre-diabetic group(848 cases,6.1 mmol/L＜fasting blood glucose ＜7.0 mmol/L), and healthy group (4562 cases, fasting blood glucose ≤6.1 mmol/L). The relationship between prediabetes mellitus and passive smoking was evaluated. Results A total of 5836 qualified samples were screened, and the sample recovery rate was 97.27%. Among the subjects, 5335 cases reported smoking history actively,among which only passive smokers accounted for 40.67%, only active smokers accounted for 3.62%, both active and passive smokers accounted for 18.33%, and those who did not smoke any cigarettes accounted for 37.38%.There were significant differences in gender, age, education level, marital status, occupation, body mass index(BMI), alcohol consumption, blood pressure, blood lipid distribution between diabetic group and healthy group (P＜0.05).Compared with the healthy group, there were statistically significant differences in the distribution of age, educational level, marital status, occupation, BMI, alcohol consumption, blood pressure and blood lipid in the pre-diabetic group(P＜0.05). There was statistical significance in smoking among healthy group, diabetic group and pre-diabetic group (P＜0.05). Generalized Logit regression analysis showed that age ≥60 years old, obesity, alcohol consumption, hypertension,dyslipidemia were risk factors for diabetes or pre-diabetes (P＜0.05). At the same time, after controlling for gender, age,education level, marital status, occupation, BMI, alcohol consumption, hypertension, dyslipidemia and other factors,there was no statistical correlation between only passive smoking or active+passive smoking and diabetes or pre-diabetes (P＞0.05). Conclusion The cross-sectional study shows that passive smoking is not associated with diabetes and pre-diabetes, but large multi-center studies are needed for further validation. 2021 Vol. 28 (12): 12-017 [Abstract] ( 43 ) HTML (40 KB)  PDF  (0 KB)  ( 4 ) 18 Influence of pharmacist participation on the treatment compliance and efficacy of patients with chronic obstructive pulmonary disease XIE Yue-hui； YUAN Qin； YANG Wu-xin Objective To explore the impact of pharmacist participation in the management of patients with chronic obstructive pulmonary disease (COPD) on compliance and efficacy. Methods A total of 60 patients with COPD who were admitted to Fengcheng Hospital of Traditional Chinese Medicine in Jiangxi Province from December 2018 to May 2019 were selected as the research objects and divided into the study group and the control group according to the random number table method, with 30 cases in each group. The control group adopted the conventional management mode, and the study group adopted the pharmacist to participate in the management. The intervention time of the two groups was 14 days. After the intervention, the cognitive score of medication safety ability, disease control, medication compliance,adverse reactions, treatment effect and self-management ability were compared between the two groups. Results Before intervention, there were no statistically significant differences in COPD assessment test (CAT) score and compliance score between the two groups (P＞0.05). After intervention, the compliance scores of the two groups were higher than those before the intervention, the CAT score was lower than that before the intervention, and the differences were statistically significant (P＜0.05). After intervention, the compliance scores in the study group were higher than those in the control group, and the CAT score was lower than that in the control group, and the differences were statistically significant (P＜0.05). The total incidence of adverse drug reactions in the study group was lower than that in the control group,and the difference was statistically significant (P＜0.05).The length of stay in the study group was shorter than that in the control group, and the hospitalization cost and hospitalization times were lower than those in the control group, the differences were statistically significant (P＜0.05).Before intervention, there was no statistical significance in the score of self-management ability between the two groups(P＞0.05). After intervention, the scores of self-management ability of patients in two groups were higher than those before intervention, and the differences were statistically significant (P＜0.05). After intervention, the scores of self-management ability in the study group were all higher than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion The participation of pharmacists in the management of COPD patients can effectively improve patients′ compliance, reduce medication errors, reduce the total incidence of adverse drug reactions, shorten hospital stays, reduce medical expenses, improve patient self-management awareness and ability, and reduce the number of hospitalizations. 2021 Vol. 28 (12): 18-021 [Abstract] ( 46 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 22 Analysis of allergens spectrum of 9478 positive cases of allergen diseases in children of Zhuhai area in the southern coastal China ZHANG Xiao-jiao；WU Hong-yuan；CHENG Li；QIU Qiong-hua Objective To analyze the allergens spectrum of childhood allergen diseases of Zhuhai area in the southern coastal China, in order to provide references for diagnosis and treatments as well as prevention of allergic diseases among children. Methods Retrospective analysis was conducted on 2146 cases of children with clinical symptoms of allergies or suspected allergic causes who were treated in the Outpatient Department of Zhuhai Municipal Maternal and Child Healthcare Hospital from January 2016 to March 2017. They accepted skin prick test (SPT) of food and inhalation allergens, among which 9478 cases showed positive. According to age (＜1 year old, 1 to ＜3 years old, 3 to ＜6 years old, 6 to 14 years old) and season (spring, summer, autumn, winter), the epidemiological characteristics of allergic diseases in children of Zhuhai area in the southern coastal China were analyzed. Results Among the 9478 positive SPT results (20 for food and 11 for inhalation), the positive rate of food was 72.23%, and that of inhalation was 27.77%. The top 9 rank of food positive allergens were milk, egg, shrimp, egg white, egg yolk, peanut, walnut, cod and crab meat.The top 9 rank of inhalation positive allergens were mite Ⅰ (dust mites), mite Ⅱ (house dust mite), cockroaches,feathers, mold Ⅰ, gramineous, cat skin, latex, dog skin. In all four seasons, milk and egg were the most common food allergies, and the highest incidence of food allergies was found in the group of ＜1 year old. Mite Ⅰ (dust mite) and mite Ⅱ (house dust mite) were the most common of inhalation allergy in four seasons, and the highest incidence of inhalation allergy was found in the group of 6-14 years old. The main allergens of food and inhalation were winter and spring. The allergen reaction intensity + was most common in the group of ＜1 year old. Allergen ++ and allergen ++++ were mainly in the group of 6-14 years old. Conclusion Allergen spectrum of childhood allergen diseases in Zhuhai area is different due to age, seasons and reaction intensity. We should implement clinical prevent intervention for allergic diseases in children of different ages and seasons, with the combination of the clinical symptoms of childhood allergic diseases and the characteristic results of SPT testing. 2021 Vol. 28 (12): 22-29转33 [Abstract] ( 42 ) HTML (42 KB)  PDF  (0 KB)  ( 6 ) 30 Construction and expression of human leukocyte antigen glycosylation site mutant plasmid vector ZHOU Xiao-man Objective To construct glycosylation site mutant plasmids of human leukocyte-C (HLA-C) gene were, and to preliminarily investigate the effects of glycosylation modification of HLA-C molecule on the function of HLA-C.Methods The HLA-C gene and HLA-C glycosylation site mutation gene were amplified by using the method of polymerase chain reaction (PCR), recovered, and connected to the PCMV-Flag eukaryotic expression vector after double enzyme digestion. The constructed plasmids were transfected into human embryonic kidney cells (293T) to express HLA-C protein and glycosylated mutant HLA-C protein, and were identified by the protein western blot method. The identified correct HLA-C gene and HLA-C glycosylation site mutation gene were connected to the carrier with red fluorescence,and transfected into 293T cells for immunofluorescence experiment to observe the expression of the protein in the cells.Results Agarose gel electrophoresis showed that HLA-C gene and HLA-C mutation gene were successfully amplified.Western Blot results showed successful expression of HLA-C protein and HLA-C glycosylated mutant proteins. Laser confocal results showed that normal HLA-C proteins were mainly expressed in the cytoplasm and peri-membrane,while most HLA-C proteins were expressed in the cytoplasm after glycosylation mutation. Conclusion The HLA-C plasmid and glycosylation site mutant plasmid vectors have been successfully constructed. The results of this experiment provide the basis and ideas for further research on glycosylation modification of HLA-C molecules. 2021 Vol. 28 (12): 30-033 [Abstract] ( 46 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 34 Research progress of exercise therapy for knee osteoarthritis LI Xing-shu；XIAO Li-na；YANG Shu-fen Knee osteoarthritis is a chronic degenerative osteoarthritis commonly occurring in middle-aged and elderly people. Knee pain, swelling, dysfunction and limited activity are the main clinical manifestations of the disease, and the quality of life of the patients will be seriously reduced in the later stage of the disease. Exercise therapy has attracted the attention of many scholars because it can effectively alleviate the symptoms of patients with knee osteoarthritis and has the advantages of simple operations, no site restriction and low economic cost. A number of guidelines at home and abroad recommend exercise therapy as a first-line treatment for knee osteoarthritis. The methods of exercise therapy for knee osteoarthritis mainly include quadriceps exercises, aquatic exercise, aerobic exercise, traditional Chinese exercise,etc. Different exercise therapy can improve the joint pain and dysfunction of patients with knee osteoarthritis to different degrees. The research progress of exercise therapy for knee osteoarthritis is summarized as follows. 2021 Vol. 28 (12): 34-037 [Abstract] ( 57 ) HTML (42 KB)  PDF  (0 KB)  ( 5 ) 38 Research progress on the relationship between Fusobacterium nucleatum,Staphylococcus aureus and inflammatory bowel disease LIU Si-yao；GAO Lian-chao；HUAI Bing-cheng；WANG Hui Inflammatory bowel disease (IBD) is a chronic non-specific inflammatory bowel disease. The incidence of IBD in China is on the rise, and the main risk factor for IBD may be intestinal bacterial infection, among which, Fusobacterium nucleatum (Fn) and Staphylococcus aureus (SA) infection, which solve IBD, have become the focus. This paper focuses on the relationship between the occurrence and development of Fn and SA and the pathogenesis of IBD.In addition, some new ideas about Fn and SA are also discussed. This paper aims to help researchers to continuously understand IBD, and to provide theoretical basis for finding new methods of diagnosis and treatment of IBD, hoping to make a modest contribution to the field of IBD. 2021 Vol. 28 (12): 38-041 [Abstract] ( 41 ) HTML (39 KB)  PDF  (0 KB)  ( 7 ) 42 Research progress of balance function in patients with type 2 diabetes mellitus LI Jing1 XIE Yi1▲ ZHAO Ming-ming2 CHEN Ke3 DONE An-qin3 NING Chao1 LI Teng-lin1 Type 2 diabetes mellitus （T2DM） affects nervous system, somatosensory system, visual system, vestibular system, and psychological system, resulting in abnormal dynamic and static balance functions. Limited balance not only increases the risk of falls in patients with T2DM, leading to soft tissue injury, fracture, brain injury, and death but also seriously affects their daily activities and quality of life. However, the understanding of limited balance function in patients with T2DM is insufficient. In this paper, the clinical manifestations, influencing factors, and rehabilitation therapy of dynamic and static balance dysfunction in patients with T2DM were discussed to provide a reference for the clinical treatment of balance dysfunction in patients with T2DM. 2021 Vol. 28 (12): 42-046 [Abstract] ( 41 ) HTML (52 KB)  PDF  (0 KB)  ( 8 ) 47 Application progress of pulmonary function test in airway obstruction caused by Mycoplasma pneumoniae pneumonia in children LI Zi-long1 LIU Xian1 TANG Hong-ping1,2▲ SHA Yong-hong1 With changes in the environment and the development of pathogenic detection methods, Mycoplasma pneumoniae (MP) has gradually become one of the main pathogens causing respiratory infections in children. In addition to symptoms such as cough and fever, MP infection can also cause airway damage, which is mainly manifested as obstructive ventilation dysfunction. Pulmonary function testing (PFT) is a clinical testing technique based on respiratory physiology and an important testing method for describing respiratory function. Whether in the acute phase or recovery phase of mycoplasma pneumoniae pneumonia (MPP), PFT can accurately determine the ventilatory dysfunction caused by MP infection and assess the severity of lung ventilatory damage. MP infection in children with asthma can induce asthma attacks and significantly reduce their lung ventilation function. In the treatment of children with asthma and MP infection, the recovery of lung ventilation function can be evaluated by comparing the changes of lung function related indicators in the acute phase and the recovery phase, and then the therapeutic effect can be evaluated. This article will review the latest research on the application of PFT to children′s MPP in recent years and put forward prospects. 2021 Vol. 28 (12): 47-050 [Abstract] ( 47 ) HTML (38 KB)  PDF  (0 KB)  ( 8 ) 51 Correlation analysis between the Neutrophil to lymphocyte ratio and the level of red blood cell distribution width in peripheral blood and liver damage in children with infectious mononucleosis LU Dan-dan1 LI Yu-fen2▲ LU Yi1 REN Dan-dan1 JIAO Hong-mei1 Infectious mononucleosis (IM) is an infectious disease of acute or subacute lymphocyte benign proliferation,caused by primary Epstein-Barr virus infection. Fever, angina and cervical lymph node enlargement are the main clinical manifestations, which can be combined with hepatomegaly and splenomegaly, and the number of abnormal lymphocytes in peripheral blood increases. Hepatic impairment is more common, accounting for about 2/3 of the number of children, and severe cases may cause liver failure or progress to Epstein-Barr virus related hemophagocytic syndrome.Its pathogenesis is complex, but immune regulation plays an important role in its pathogenesis. The neutrophil to lymphocyte ratio (NLR) can reflect the inflammation, immunity and nutritional status of patients. According to relevant literature reports in recent years, red blood cell distribution width (RDW) is also a new inflammatory marker in blood routine, which is closely related to the judgment or prognosis of various liver diseases. NLR and RDW are effective indicators for evaluating various liver diseases in adult patients, but their practicability in liver damage of pediatric IM patients is still unclear. This paper will analyze and summarize the relevant studies on the levels of NLR and RDW in peripheral blood and the liver damage in children with IM, so as to provide important reference value for early prevention, early detection, improvement of long-term prognosis, treatment of diseases and evaluation of prognosis. 2021 Vol. 28 (12): 51-53转58 [Abstract] ( 49 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 54 Research progress in management of perinatal pregnant with systemic lupus erythematosus ZHANG Zhi-dan XU Yong-zhi▲ XIE Tong▲ Systemic lupus erythematosus (SLE) is an autoimmune disease affecting multiple systems. Due to the mutual influence between SLE and pregnancy, pregnancy may cause SLE relapse and SLE may cause adverse pregnancy outcomes, affecting the life quality of women and their families. At the same time, whether female patients with SLE will affect the health and development of offspring has not been determined. Therefore, this paper mainly reviews the perinatal management of pregnancy with SLE. 2021 Vol. 28 (12): 54-058 [Abstract] ( 48 ) HTML (44 KB)  PDF  (0 KB)  ( 6 ) 59 Experimental study of low frequency ultrasound in the treatment of chemotherapy-induced phlebitis WEN Mian-mian1 SHANG Yao-yao1 WANG Yi2▲ Objective To explore the effect of low-frequency ultrasound in the treatment of chemotherapy-induced phlebitis and its influence on inflammatory indexes, so as to provide experimental basis for the mechanism research of chemotherapy phlebitis. Methods A total of 40 male SD rats were selected and divided into the blank control group,the model group, the Hirudoid Cream treatment group and the low-frequency ultrasound treatment group according to the random number table method, 10 rats in each group. Except for the blank control group, the last 3 groups were all injected with Vinorelbine through tail vein to establish an animal model of chemotherapy-induced phlebitis. The blank control group and the model group were not treated. The Hirudoid Cream treatment group was treated for 3 consecutive days by Hirudoid Cream. The Low-frequency ultrasound treatment group was treated for 3 consecutive days by lowfrequency ultrasound, 30 min each time. The changes of local appearance and pathomorphology of the injection site of tail vein were observed, and the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in peripheral blood serum were detected. Results Compared with the blank control group, the model group showed obvious venous inflammation. The levels of TNF-α in the model group was higher than that in the blank control group, while the level of IL-6 in the model group was lower than that in the blank control group (P＜0.05). Compared with the model group,the Hirudoid Cream treatment group and the low-frequency ultrasound treatment group showed a significant improvement in inflammation. The levels of TNF-α in the both treatment group were lower than those in the model group,while the serum levels of IL-6 in the both treatment group were higher than those in the model group (P＜0.05). There were no significant differences in the levels of TNF-α and IL-6 between the Hirudoid Cream treatment group and the low-frequency ultrasound treatment group (P＞0.05). Conclusion Low-frequency ultrasound alleviates the damage of chemotherapy-induced phlebitis by down regulating the level of TNF-α and increasing the level of IL-6. 2021 Vol. 28 (12): 59-061 [Abstract] ( 44 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 62 Expression changes and clinical significance of STAT3 and EGFR in cervical intraepithelial neoplasia GAO Yan-hua Objective To investigate the expression changes and clinical significance of signal transducer and activator of transcription 3 (STAT3) and epidermal growth factor receptor (EGFR) in patients with cervical intraepithelial neoplasia (CIN). Methods The clinical data of 260 patients with CIN admitted to Liaoyang Central Hospital from December 2018 to December 2019 were retrospectively collected. According to the cervical lesions, they were divided into the CIN class Ⅰgroup (mild atypical hyperplasia, 102 cases), the CIN class Ⅱgroup (moderate atypical hyperplasia, 89 cases) and the CIN class Ⅲgroup (severe atypical hyperplasia and carcinoma in situ, 69 cases). The expression levels of STAT3 and EGFR were compared among the three groups, and the ROC curve was drawn to analyze the value of STAT3 and EGFR expression and their combined detection in the diagnosis of CIN. Results Western blot analysis showed that the expression levels of STAT3 and EGFR in the CIN class Ⅲgroup were higher than those in the CIN class Ⅱgroup and the CIN class Ⅰgroup and the differences were statistically significant (P＜0.05). AUC of STAT3 and EGFR in diagnosing CIN was 0.807 and 0.835 respectively, which had certain diagnostic value. The AUC of combined detection was 0.903, and the specificity and sensitivity of combined detection were higher than those of single detection, which indicated that the diagnostic performance of combined detection was high. Conclusion The expression levels of STAT3 and EGFR are all related to the degree of cervical intraepithelial neoplasia. Combined detection of their levels has high diagnostic value and can be used for early prediction of clinical cervical cancer. 2021 Vol. 28 (12): 62-064 [Abstract] ( 44 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 65 Changes and significance of interleukin-35 before and after the treatment of severe hepatitis by plasma diafiltration LIAO Yan-xia HE De-ning CHEN Wei-guo Objective To investigate the changes and significance of interleukin-35 (IL-35) before and after the treatment of severe hepatitis by plasma diafiltration (PDF). Methods A total of 40 patients with severe hepatitis admitted to Pingxiang People′s Hospital from July 2018 to July 2019 were selected as the study group, and 40 healthy patients who underwent physical examinations in this hospital during the same period were selected as the control group. The serum IL-35 levels of the two groups were compared. The serum IL-35 level, biochemical indicators, and electrolytes of the study group before and after treatment were also compared. The correlation between serum IL-35 level and biochemical indicators and electrolytes was analyzed. Results The serum IL-35 level in the study group was (23.23±6.32) pg/mL,lower than that in the control group of (101.92±12.47) pg/mL, and the difference was statistically significant (P＜0.05).In the study group, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBil),and sodium ion (Na+) after treatment were lower than those before treatment, IL-35 level was higher than that before treatment, and the differences were statistically significant (P＜0.05). The IL-35 was negatively correlated with AST,ALT, TBil, Na+(r=-0.267, -0.492, -0.444, -0.413, P＜0.05). Conclusion IL-35 is in low expression of severe hepatitis,and it is significantly increased after treatment. It may be involved in the development of severe hepatitis. Detection of IL-35 can assess the severity and prognosis of patients and guide treatment. 2021 Vol. 28 (12): 65-067转70 [Abstract] ( 43 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 68 Clinical effect of biofeedback combined with family training in the treatment of patients with functional defecation dysporia YANG Xue-chun SUN Bin-bin SUN Bing ZHANG Li HAN Jing-ying Objective To explore the clinical effect of biofeedback combined with family training in the treatment of patients with functional dysporia. Methods A total of 80 patients with functional defecation disorders who were treated in Beijing Rectum Hospital from January 2019 to March 2020 were selected as the research objects, and divided into the observation group (40 cases)and the control group (40 cases)according to random number table method.The control group was treated with biofeedback therapy,and the observation group was treated with family training program on the basis of the control group. The defecation and quality of life of the two groups were compared. Results After intervention,the defecation time and defecation frequency scores of the two groups were lower than those before intervention, and the defecation time and defecation frequency scores of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). After intervention, scores of physical life, social, physical and psychological functions in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Biofeedback combined with family training can effectively alleviate patients′ defecation barriers, improve their defecation function and improve patients′ quality of life, which is worthy of promotion. 2021 Vol. 28 (12): 68-070 [Abstract] ( 49 ) HTML (28 KB)  PDF  (0 KB)  ( 7 ) 71 Clinical effect of pressure gloves combined with simple palmar carpal butt in the treatment of hemiplegic shoulder-hand syndrome ZOU Gui-di TAN Hui-hong LI Nan ZENG Qing-hao Objective To investigate the clinical effect of pressure gloves combined with simple palmar carpal butt in the treatment of hemiplegic shoulder-hand syndrome. Methods A total of 75 patients with hemiplegic shoulder-hand syndrome treated in Huizhou Third People′s Hospital from January 2019 to October 2020 were selected as subjects.The patients were divided into three groups by the random number table method, 25 cases in each group. The control group was treated with routine rehabilitation,experimental group 1 wore simple palmar carpal butt on the basis of routine rehabilitation treatment, and experimental group 2 wore pressure gloves on the basis of experimental group 1. The degree of hand swelling and the movement of metacarpophalangeal joints were compared before treatment and after 2 weeks of treatment. Results There were no statistically significant differences in the degree of hand swelling and movement of the metacarpophalangeal joints among the three groups before treatment (P＞0.05). The hand swelling degree of the three groups after 2 weeks of treatment was lower than that before treatment, and the movement of metacarpophalangeal joints was higher than that before treatment, the differences were statistically significant (P＜0.05). The hand swelling degree after 2 weeks of treatment of the experimental group 1 and experimental group 2 was lower than that of the control group, the differences were statistically significant (P＜0.05). The hand swelling degree after 2 weeks of treatment in the experimental group 2 was lower than that in the experimental group 1,the difference was statistically significant(P＜0.05).The movement of metacarpophalangeal joints in the experimental group 1 and experimental group 2 after 2 weeks of treatment was lower than that in the control group, the differences were statistically significant (P＜0.05). The movement of metacarpophalangeal joints after 2 weeks of treatment in the experimental group 2 was lower than that in the experimental group 1, the difference was statistically significant (P＜0.05). Conclusion The application of pressure gloves combined with simple palmar carpal butt in clinical treatment of hemiplegic shoulder-hand syndrome can improve the therapeutic effect, reduce the degree of hand swelling and improve the movement of metacarpophalangeal joints. 2021 Vol. 28 (12): 71-073 [Abstract] ( 52 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 74 Clinical effect of Acitretin combined with Capestriol Ointment in the treatment of plaque psoriasis LIANG Jun-ming1 TAN Miao-hua2 CHEN Gui-zhen3 Objective To investigate the clinical effect of Acitretin combined with Capotriol Ointment in the treatment of plaque psoriasis. Methods A total of 62 patients with plaque psoriasis diagnosed and treated in Dermatology Hospital of Xinhui District in Jiangmen City from May to August 2019 were selected as the research subjects, and divided into the control group (31 cases) and the experimental group (31 cases) according to random number table method. The control group was treated with Capotriol Ointment, and the experimental group was treated with Abitra combined with Capotriol Ointment. Skin lesions, dermatological life quality index (DLQI) score, clinical efficacy and the incidence of adverse reactions were compared between the two groups. Results Before treatment, there were no significant differences in psoriasis area and severity (PASI) score and DLQI score between the two groups (P＞0.05). After treatment,PASI score and DLQI score of the two groups were lower than those before treatment, PASI score and DLQI score of the experimental group were lower than those of the control group, the differences were statistically significant (P＜0.05).The total effective rate of experimental group was higher than that of control group, and the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion The combination of Acitretin and Capestriol Ointment in the treatment of plaque psoriasis has significant effect, can improve the symptoms, improve the quality of life, worthy of clinical application. 2021 Vol. 28 (12): 74-076 [Abstract] ( 56 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 77 Clinical application effect of early intravenous heparinization in elderly patients with acute ST-segment elevation myocardial infarction XIE Zhi-hui SHEN You-quan HOU Dong-zi Objective To observe the clinical application effect of early intravenous heparinization in elderly patients with acute ST-segment elevation myocardial infarction (STEMI). Methods A total of 100 patients diagnosed with acute STEMI who were admitted to Yuedong Hospital, the Third Affiliated Hospital of Sun Yat-sen University from January 2019 to May 2020 were selected as the research objects. All patients planned to undergo coronary angiography and percutaneous coronary intervention (PCI). The patients were divided into the control group and the experimental group by random drawing, with 50 cases in each group. The experimental group was treated with unfractionated Heparin,while the control group was not given Heparin before operation. The coronary angiography, the peak time of serum myocardial markers such as troponin I (cTnI) and creatine kinase isoenzyme (CK-MB), hospitalization time, major cardiovascular and bleeding events occurring within 30 days outside the hospital were compared between the two groups. Results The thrombus aspiration rate (28.00%) of the experimental group was lower than that of the control group(48.00%), while the thrombolysis rate (40.00%) was higher than that of the control group (12.00%), the use rate of Tirofiban (28.00%) was lower than that of the control group (72.00%), the incidence of no-reflow (0.00%) was lower than that of the control group (12.00%), proportion of TIMI grade 3 blood flow (62.00%) was higher than that of control group (40.00%), the differences were statistically significant (P＜0.05). The peak time of cTnI and CK-MB serum myocardial markers and hospitalization time in the experimental group were shorter than those in the control group, the differences were statistically significant (P＜0.05). The incidence rate of bleeding in the experimental group (0.00%) was lower than that in the control group (10.00%), while the ST segment resolution rate (76.00%) was higher than that in the control group (54.00%), the differences were statistically significant (P＜0.05). Conclusion In the elderly patients with acute STEMI, early intravenous heparinization therapy can significantly improve the situation of coronary angiography. 2021 Vol. 28 (12): 77-079转83 [Abstract] ( 40 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 80 Application of graded management of home oxygen therapy in elderly patients with stable chronic obstructive pulmonary disease HUANG Li-ling Objective To investigate the application value of home oxygen therapy graded management in elderly patients with chronic obstructive pulmonary disease (COPD) at stable stage. Methods A total of 82 elderly patients with COPD in stable stage admitted to the Joint Logistics Support Force No.900 Hospital Putian Medical District from October 2017 to December 2018 were selected as the research subjects, and divided into the control group (41 cases) and the observation group (41 cases) according to random number table method. The control group received routine intervention, the observation group was given an intervention mode of family oxygen therapy hierarchical management on the basis of the control group. Acute attack and hospitalization during the intervention, forced expiratory volume in the first second (FEV1), FEV1/forced vital capacity (FVC), and blood gas analysis of arterial oxygen content (PaO2) and arterial carbon dioxide content (PaCO2) were compared between the two groups. Results The times of acute attacks and hospitalizations in the observation group were less than those in the control group during the intervention period, and the differences were statistically significant (P＜0.05). After intervention, FEV1, FEV1/FVC and PaO2 in both groups were higher than those before intervention, and PaCO2 was lower than that before intervention, and FEV1, FEV1/FVC and PaO2 in the observation group were higher than those in the control group, and PaCO2 was lower than that in the control group, the differences were statistically significant (P＜0.05). Conclusion The hierarchical management of home oxygen therapy can reduce the number of acute attacks and hospitalizations of elderly patients with stable COPD, improve lung function and hypoxia, and reduce the content of blood carbon dioxide. 2021 Vol. 28 (12): 80-083 [Abstract] ( 44 ) HTML (35 KB)  PDF  (0 KB)  ( 5 ) 84 Effect of Kangfuxin Liquid combined with Pantoprazole Sodium Enteric Capsules in the treatment of peptic ulcer LI Qin LI Jing-ru MA Zhi-hui ZHANG Li GAO Xiao-hua WANG Yin-ying▲ Objective To investigate the effect of Kangfuxin Liquid combined with Pantoprazole Sodium Enteric Capsules in the treatment of peptic ulcer. Methods A total of 88 patients with peptic ulcer who were treated in Huai′an Medical Area, General Hospital of Chinese People′s Liberation Army Eastern Theater Command from December 2015 to March 2017 were selected as the research subjects, and they were divided into observation group (42 cases) and control group (46 cases) according to different treatment regimen. Control group was treated with Pantoprazole Sodium Enteric Capsules, and observation group was treated with Kangfuxin Liquid combined with Pantoprazole Sodium Enteric Capsules. In the observation group, there were 20 cases of gastric ulcer and 22 cases of duodenal bulb ulcer. In the control group, there were 22 cases of gastric ulcer and 24 cases of duodenal ulcer. The improvement time of various clinical symptoms (epigastric pain, abdominal distention, belching and acid reflux) was compared between the two groups. Clinical symptom scores of two groups were compared before and after treatment. The overall treatment effect of the two groups was compared. The treatment effect of duodenal bulb ulcer and gastric ulcer was compared between the two groups. The incidence of adverse reaction was compared between the two groups. The recurrence rate of ulcer in healed patients was compared between the two groups at 6 and 12 months of follow-up. Results After 8 weeks of treatment, the improvement time of epigastric pain, abdominal distention, belching and acid reflux in the observation group was shorter than that in the control group, with statistical significance (P＜0.05). The scores of epigastric pain, abdominal distention, belching and acid reflux symptoms in the two groups after treatment were lower than those before treatment, and the scores of epigastric pain, abdominal distention, belching and acid reflux symptoms in the observation group were lower than those in the control group after treatment, with statistical significances (P＜0.05). The healing rate and overall effective rate of treatment in observation group were higher than those in the control group, with statistical significances (P＜0.05). After treatment, the cure rate and total effective rate of patients with duodenal bulb ulcer and gastric ulcer in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reaction between the two groups after treatment (P＞0.05). At the 6th and 12th months of follow-up, the recurrence rates of ulcer in healed patients of observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Kangfuxin Liquid combined with Pantoprazole Sodium Enteric Capsules has a good clinical effect in the treatment of peptic ulcer. It can effectively improve the clinical symptoms, shorten the healing time, reduce the recurrence rate, and have less adverse reactions, which is worthy of clinical promotion and application. 2021 Vol. 28 (12): 84-088 [Abstract] ( 58 ) HTML (47 KB)  PDF  (0 KB)  ( 6 ) 89 Clinical value of Tacrolimus Ointment combined with Desonide Cream in the treatment of hand eczema HE Wen-qiang Objective To investigate the clinical value of Tacrolimus Ointment combined with Desonide Cream in the treatment of hand eczema. Methods A total of 90 patients with hand eczema diagnosed and treated in Iron Coal General Hospital of Liaoning Health Industry Group from January to December 2019 were selected as the research subjects and divided into the control group (45 cases) and the experimental group (45 cases) according to random number table method. The control group was treated with Desonide Cream, and the experimental group was treated with Tacrolimus Ointment combined with Desonide Cream. Clinical efficacy, hand eczema (JHS) score and adverse reactions were compared between the two groups. Results The total effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P＜0.05). After treatment, the JHS score of the two groups was lower than that before treatment, and the JHS score of the experimental group was lower than that of the control group, the differences were statistically significant (P＜0.05). The total incidence of adverse reactions in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The combination of Tacrolimus Ointment and Desonide Cream in the treatment of hand eczema has definite clinical efficacy and high safety, which is worthy of clinical promotion and application. 2021 Vol. 28 (12): 89-091 [Abstract] ( 72 ) HTML (29 KB)  PDF  (0 KB)  ( 6 ) 92 Clinical analysis of perioperative blood transfusion indications in elderly patients with hip fracture CHEN Guo-qing1 SONG Jing-zi1,2 HUANG Hong-yu1 Objective To explore the clinical indications of perioperative blood transfusion in elderly patients with hip fracture. Methods A total of 200 elderly patients with hip fracture admitted to the Lianjiang People′s Hospital of Guangdong Province from July 2019 to May 2020 were selected as the research objects and divided into experimental group (100 cases) and control group (100 cases) according to the computer randomized method. The control group was treated with blood transfusion when the hemoglobin(Hb)＜70 g/L,and the experimental group treated with blood transfusion when Hb ＜100 g/L. The total incidence of complications, anemia correction time, incision healing time and hospital stay time were compared between the two groups. Results The total incidence of complications in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The time of anemia correction in the experimental group was shorter than that in the control group, and the difference was statistically significant (P＜0.05). There were no significant differences in incision healing time and hospital stay time between the two groups(P＞0.05).Conclusion The elderly patients with hip fracture receive blood transfusion intervention under the condition of perioperative blood transfusion indication, which can promote the improvement of anemia signs quickly and has certain value. 2021 Vol. 28 (12): 92-094 [Abstract] ( 45 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 95 Effect observation of selective decompression and fusion in the treatment of multiple segment lumbar spinal stenosis with degenerative spondylolisthesis ZHANG Hong-liang WENG Yang-hua LI Pei-zhen YI Li CHEN Li-yan LI Zhong-hui Objective To explore the clinical effect of selective decompression and fusion in the treatment of multiple segment lumbar spinal stenosis with degenerative spondylolisthesis. Methods A total of 80 patients with multiple segment lumbar spinal stenosis with degenerative spondylolisthesis admitted to Dongguan Humen Hospital from April 2009 to April 2019 were selected as the research objects and divided into the control group (40 cases) and the observation group (40 cases) according to random number table method. The control group was treated with multiple segment decompression and fusion, and the observation group was treated with selective decompression and fusion. The operation time, intraoperative blood loss, proportion of fusion segments, visual analogue scale (VAS) for low back pain and leg pain, Japanese orthopedic association (JOA) score, and oswestry disability index (ODI) were compared between the two groups. Results The operation time of the observation group was shorter than that of the control group, and the difference was statistically significant (P＜0.05). The intraoperative blood loss was less than that of the control group, the difference was statistically significant (P＜0.05). There were no significant differences in the VAS scores of leg pain and low back pain, JOA score and ODI score bwtweem the two groups before and after treatment (P＞0.05). The scores of leg pain VAS and low back pain , JOA score of the two group were lower than those before treatment, the ODI score of the two groups was higher than that before treatment, and the differences were statistically significant (P＜0.05). The proportion of fusion segments in the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion Selective decompression and fusion in the treatment of multiple segment lumbar spinal stenosis with degenerative spondylolisthesis has certain clinical effect. 2021 Vol. 28 (12): 95-097 [Abstract] ( 33 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 98 Comparison of the effect of modified lateral straight incision and lateral L-shaped incision in the treatment of calcaneal fractures JIANG Hong-geng HUANG Wu-bin ZHENG Ning Objective To explore the clinical effects of modified lateral straight incision and lateral L-shaped incision in the treatment of calcaneal fractures. Methods A total of 46 patients with calcaneal fractures admitted to the Department of Orthopedics, Jieyang People′s Hospital from December 2015 to February 2020 were selected as the research objects. They were divided into the control group and the study group according to the random table method, with 23 cases in each group. The control group were treated with the lateral L-shape incision, and the study group were treated with modified lateral straight incisions. The surgical indicators, complications and curative effects were compared between the two groups. Results The operation time and hospital stay time in the study group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). The length of surgical incision in the study group was shorter than that in the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in intraoperative blood loss between the two groups (P＞0.05). The total incidence of complications in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The total effective rate in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The modified lateral straight incisions applicated in calcaneal fracture, shorten the hospital stay time and operation time, save the treatment cost, reduce the complications such as incision infection and skin edge necrosis, which could be applied and promoted. 2021 Vol. 28 (12): 98-100转104 [Abstract] ( 54 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 101 Effect of platelet-rich plasma combined with knee arthroscopy on pain and functional rehabilitation of patients with knee osteoarthritis BI Sheng-rong1 YANG Guo-ping1 XIAO Zhu-feng2 Objective To explore the effect of platelet-rich plasma combined with knee arthroscopy on pain and functional rehabilitation of patients with knee osteoarthritis. Methods A total of 84 patients with knee osteoarthritis admitted to Ganzhou People′s Hospital and the Second People′s Hospital of Ningdu County from January 2018 to December 2019 were selected as the research subjects and divided into the experimental group (42 cases) and the control group(42 cases) according to random number table method. The experimental group was treated with platelet-rich plasma injection combined with knee arthroscopic surgery, and the control group was treated with single knee arthroscopic surgery. The function of knee joint function, pain degree, synovial fluid cytokine level and adverse reactions after operation were compared between the two groups. Results There were no significant differences in visual analogue scale(VAS) scores, Lysholm scores, synovial fluid tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) between the two groups before operation (P＞0.05). Six months after operation, the VAS scores, synovial fluid TNF-α and IL-1β levels in the two groups were lower than those before the operation, and the Lysholm scores of the two groups were higher than those before the operation, the differences were statistically significant (P＜0.05). Six months after operation, the Lysholm score of the experimental group was higher than that of the control group, and the VAS score, synovial fluid TNF-α and IL-1β levels were lower than those of the control group, the differences were statistically significant (P＜0.05). There were no adverse reactions during or after operation in the two groups. Conclusion Platelet-rich plasma combined with knee arthroscopic surgery for knee osteoarthritis could reduce inflammation, relieve pain, improve knee joint function, with good safety. 2021 Vol. 28 (12): 101-104 [Abstract] ( 54 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 105 Clinical effect and safety of SOX regimen in the treatment of advanced triple negative breast cancer LU Ying Objective To explore the clinical effect and safety of SOX regimen (Oxaliplatin combined with Teggio) in the treatment of advanced triple negative breast cancer, so as to provide a reference for clinicians to choose rational drug regimen. Methods A total of 102 patients with advanced triple negative breast cancer admitted to Zhongyi Northeast International Hospital from January 1, 2017 to December 31, 2019 were selected as the research objects, and they were divided into the control group and the experimental group according to random number table method, with 51 cases in each group. The experimental group was treated with SOX regimen, while the control group was treated with TP regimen (Oxaliplatin combined with Docetaxel). The total effective rate, total incidence of adverse reactions, serum carbohydrate antigen 153 (CA153) and cancer embryo antigen (CEA) levels were compared between the two groups. Results The total effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The total incidence of adverse reactions in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05). After treatment, the serum CA153 and CEA levels in two groups were lower than those before treatment, and the serum CA153 and CEA levels in experimental group were lower than those in control group, the differences were statistically significant (P＜0.05). Conclusion In the treatment of advanced triple negative breast cancer, SOX regimen has significant clinical effect and higher safety,which is worthy of promotion and application in future clinical work. 2021 Vol. 28 (12): 105-107转111 [Abstract] ( 56 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 108 Clinical effect of Amlotinib in second-line treatment of advanced nonsmall cell lung cancer LUO Qiu-yu LI Guo-wen Objective To observe the clinical effect and toxicity of Amlotinib in second-line treatment of advanced non-small cell lung cancer. Methods A total of 52 patients with advanced non-small cell lung cancer admitted to People′s Hospital of Chaozhou City from January 2019 to March 2020 were selected as the research objects. After progression of first-line chemotherapy, the patients were divided into chemotherapy group (32 cases) and Amlotinib group(20 cases) on a voluntary basis. Patients in the chemotherapy group were treated with Paclitaxel combined with Cisplatin, and patients in the Amlotinib group were treated with Amlotinib Capsules orally. The short-term efficacy and the occurrence of toxic and side effects were compared between the two groups. Results There were no statistically significant differences in objective effective rate and disease control rate between the two groups (P＞0.05). The incidence of anorexia and gastrointestinal reactions in the Amlotinib group were lower than those in the chemotherapy group, and the differences were statistically significant (P＜0.05). There were no statistically significant differences in the incidence rates of bleeding, hypertension, myelosuppression, hand-foot syndrome, oral ulcer, liver and kidney function injury and fatigue between the two groups (P＞0.05). Conclusion The clinical effect of Amlotinib as a second-line regimen in advanced non-small cell patients is similar to that of chemotherapy , and the adverse reactions are fewer. 2021 Vol. 28 (12): 108-111 [Abstract] ( 52 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 112 Clinical effect of maintenance chemotherapy with Gemcitabine in the treatment of advanced lung squamous cell carcinoma BI Da-peng Objective To investigate the clinical effect of Gemcitabine with maintenance chemotherapy in the treatment of advanced lung squamous cell carcinoma. Methods A total of 68 patients with advanced lung squamous cell carcinoma admitted to Anshan Cancer Hospital from July 2016 to January 2020 were selected as the research objects. They were divided into the control group and the experimental group according to the random number table method, with 34 cases in each group. In the control group, best supportive treatment was used, and in the experimental group, Gemcitabine with maintenance chemotherapy was adopted. The clinical effect, incidence of adverse reactions and progression-free survival were compared between the two groups. Results There were no statistically significant differences in the total effective rate and disease control rate between the two groups (P＞0.05). The incidence rates of liver function damage, gastrointestinal reaction, hair loss and neurotoxicity in observation group were lower than those in control group, and the differences were statistically significant (P＜0.05). There were no statistically significant differences in the incidence rates of renal function impairment and rash between the two groups (P＞0.05). The progression-free survival in the experimental group was longer than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The clinical effect of maintenance chemotherapy with Gemcitabine for patients with advanced lung squamous cell carcinoma is the same as the best supportive treatment, but the incidence of adverse reactions is low and the progression-free survival period is high. It is worthy of promotion and application in future clinical practice. 2021 Vol. 28 (12): 112-114转118 [Abstract] ( 60 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 115 Effect of 3% hypertonic saline combined with Compound Ipratropium Bromide Solution atomization inhalation in the treatment of respiratory syncytial virus pneumonia ZHANG Zhao-wen HU Bing WANG Gui-lian ZENG Kai-Dan HU Hua-zhu Objective To investigate the effect of 3% hypertonic saline combined with Compound Ipratropium Bromide Solution atomization inhalation in the treatment of respiratory syncytial virus pneumonia. Methods A total of 195 children with respiratory syncytial virus pneumonia who were treated in People′s Hospital of Yichun City, Jiangxi Province from January 2015 to December 2016 were selected as the research subjects. According to the random number table method,they were divided into treatment group 1(65 cases),treatment group 2 (65 cases) and treatment group 3 (65 cases). The treatment group 1 received 3% hypertonic saline 4 mL + Compound Ipratropium Bromide Solution atomized inhalation. The treatment group 2 was treated with 4 mL of normal saline + Compound Ipratropium Bromide Solution atomized inhalation. The treatment group 3 was treated with 0.9% sodium chloride solution 2 mL + Terbutaline Sulfate Atomized Solution + Budesonide Suspension atomized inhalation. The time of cough disappearance, shortness of breath disappearance, asthma disappearance, lung signs disappearance, hospital stay and treatment effect of the three groups were compared. Results The disappearance time of cough, shortness of breath, dyspnea, lung signs and hospitalization time in treatment group 1 were shorter than those in treatment group 2 and treatment group 3, with statistical significances (P＜0.05). However, there were no significant differences in the disappearance time of cough, shortness of breath,dyspnea, lung signs and hospitalization time between the treatment group 2 and treatment group 3 (P＞0.05). The total effective rate of treatment group 1 was higher than that of treatment group 2 and treatment group 3, and the difference was statistically significant (P＜0.05). However, there was no significant difference in the total effective rate between the treatment group 2 and treatment group 3 (P＞0.05). Conclusion 3% hypertonic saline combined with Compound Ipratropium Bromide Solution atomization inhalation in the treatment of respiratory syncytial virus pneumonia has a high cure rate, which can relieve cough, shortness of breath, shortness of breath, lung signs and shorten the duration of hospitalization as soon as possible. It′s worth popularizing. 2021 Vol. 28 (12): 115-118 [Abstract] ( 48 ) HTML (1 KB)  PDF  (0 KB)  ( 8 ) 119 Influence of induction of labor on pregnancy outcome of vaginal birth after cesarean section YANG Yuan-qiang HUANG Xue-ping Objective To investigate whether induction of labor increases the complications of trial of labor after cesarean (TOLAC) section and the impact of different methods of induction on TOLAC. Methods Data of 2292 pregnant women who were hospitalized in the Department of Obstetrics in Jiangmen Central Hospital from January 2015 to December 2017 were retrospectively analyzed. According to whether they received labor induction or not, pregnant women were divided into labor induction group and natural labor group. The general conditions and pregnancy outcomes of pregnant women in the induced labor group and the natural labor group were analyzed and compared to understand whether the induced labor increased the maternal and infant risk of TOLAC. According to the different methods of labor induction, the pregnant women in the labor induction group were divided into the Oxytocin labor induction group and the balloon labor induction group. The general situation and pregnancy outcome of the pregnant women in the Oxytocin labor induction group and the balloon labor induction group were analyzed and compared, so as to understand the influence of different methods of labor induction on vaginal birth after cesarean (VBAC). Results There were 576 pregnant women with TOLAC, 56 in induced labor group and 520 in natural labor group. In the labor induction group, 37 were in the Oxytocin group and 19 in the balloon group. The age and gestational age of labor induction group were higher than those of natural labor group, the success rate of trial labor was lower than that of natural labor group, the amount of postpartum blood loss at 24 h was more than that of natural labor group, and the length of hospital stay was longer than that of natural labor group, the differences were statistically significant (P＜0.05). There were no significant differences in the rate of forceps delivery, the incidence of maternal complications and neonatal complications between the induced labor group and the natural labor group (P＞0.05). The age of the Oxytocin induced labor group was higher than that of the balloon induced labor group, and the length of hospital stay was shorter than that of the balloon induced labor group, the differences were statistically significant (P＜0.05). However, there were no significant differences in gestational age, success rate of trial labor, forceps delivery rate, postpartum blood loss at 24 h, incidence of maternal complications and neonatal complications between the Oxytocin induced labor group and the balloon induced labor group(P＞0.05). Conclusion Under strict supervision, the induction of labor during TOLAC is safe and effective, but the induction of labor reduces the success rate of VBAC, and the indications and contraindications of labor induction should be strictly controlled. There is no significant difference between low-dose Oxytocin induction and balloon induction in terms of the effect of labor induction and the possible complications of mother and infant. The choice of different methods mainly depends on the pregnant women′s cervical maturity. 2021 Vol. 28 (12): 119-122 [Abstract] ( 36 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 123 Clinical effect of Methylprednisolone combined with Aspirin on children with Kawasaki diseases and the influence on children′s serum high-sensitivity C-reactive protein and B-type natriuretic peptide levels LI Li-li Objective To investigate the clinical effect of Methylprednisolone combined with Aspirin on children with Kawasaki diseases and the influence on children′s serum high-sensitivity C-reactive protein (hs-CRP) and B-type natriuretic peptide (BNP). Methods From May 2016 to May 2020, 80 children with Kawasaki diseases admitted to the Department of Pediatric Internal Medicine of Donggang Central Hospital were selected as the research subjects. They were divided into two groups by computer random number method, each with 40 cases. The children in the control group were treated with Aspirin, and the children in the observation group were treated with Methylprednisolone and Aspirin. The clinical symptom improvement time, hospital stay and coronary artery injury were compared between the two groups. The serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), hs-CRP and BNP before and after treatment were compared between the two groups. Results In the observation group, the subsidence time of mucosal congestion, hand and foot swelling, neck lymph node enlargement, fever abatement time, rash resolution time and hospital stay time were shorter than those in the control group, with statistical significances (P＜0.05). After 3 months of follow-up, the incidence of coronary artery injury in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Before treatment, there were no significant differences in serum TNF-α, IL-6, hs-CRP and BNP between the two groups (P＞0.05). After treatment, the levels of TNF-α, IL-6, hs-CRP and BNP in the observation group were lower than those in the control group, with statistical significances (P＜0.05).Conclusion The combination of Methylprednisolone and Aspirin in children with Kawasaki diseases can facilitate improvement of symptoms, reduce coronary artery damage, shorten hospital stay, and greatly improve serum levels of TNF-α, IL-6, hs-CRP, and BNP, which is worthy of application. 2021 Vol. 28 (12): 123-126 [Abstract] ( 45 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 127 Study on serum vitamin D levels in children with community-acquired pneumonia LI He1 LIU Jian-ying2▲ Objective To investigate the relationship between serum vitamin D (VD) levels and severity and age of children with community-acquired pneumonia (CAP), so as to provide evidence for the prediction and assessment of the condition of CAP and the supplement of VD. Methods A total of 145 CAP children hospitalized in Chengde Central Hospital from November 2018 to November 2019 were selected as the research objects. According to the severity of the disease, they were divided into mild pneumonia group (100 cases) and severe pneumonia group (45 cases). According to the age, they were divided into infant group (31 cases) and preschool group (114 cases). Serum 25-(OH)D levels were compared in each group. Results The average serum 25-(OH)D level of 145 CAP patients was (23.4±9.0) ng/mL, among which the 25-(OH)D level was normal in 89 cases (61.38%), less in 26 cases (17.93%), deficient in 30 cases(20.69%), and severe deficient in 0 cases. The level of 25-(OH)D in the mild pneumonia group was higher than that in the severe pneumonia group,and the detection rate of 25-(OH)D deficiency(including deficiency)in the severe pneumonia group was higher than that in the mild pneumonia group, and the differences were statistically significant (P＜0.05). The serum level of 25-(OH)D in the infant group was higher than that in the preschool group, and the difference was statistically significant (P＜0.05). The level of 25-(OH)D in the infant group with mild pneumonia was higher than that of the preschool group, and the difference was statistically significant (P＜0.05). There was no significant difference in serum 25-(OH)D level between the children with severe pneumonia group and the preschool group (P＞0.05). Conclusion The serum VD level of children with severe CAP is lower than that of children with mild CAP, which may be related to age. 2021 Vol. 28 (12): 127-129 [Abstract] ( 46 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 130 Application effect of modified closed-mouth impression in repairing complete dentures in elderly patients LI Bing-ting ZHANG Yong YANG Dong-qing Objective To explore the application effect of modified closed-mouth impression in repairing complete dentures in elderly patients. Methods A total of 80 elderly patients who received complete denture restoration in the Department of Stomatology, Shaoguan Stomatological Hospital from August 2018 to August 2019 were selected as the research subjects. According to the random number talbe method, the patients were divided into the conventional group(40 cases, 55 teeth) and the improved group (40 cases, 58 teeth). The conventional group was treated with traditional open impression, while the improved group was treated with modified closed-mouth impression. The clinical effects,complete denture restoration effects, the total incidence of adverse reactions, and the qualified rate of denture restoration quality of patients between the two groups 2 months after treatment were compared. Results The total effective rate of the improved group was higher than that of the conventional group, and the difference was statistically significant (P＜0.05). The scores of masticatory function, oral comfort, denture retention and language function in the modified group were higher than those in the conventional group, and the differences were statistically significant (P＜0.05). The qualified rates of denture stability, denture retention and edge extension of denture base in the modified group were higher than those in the conventional group, and the differences were statistically significant (P＜0.05). The total incidence of adverse reactions in patients of modified group was lower than that of conventional group, and the difference was statistically significant (P＜0.05). Conclusion In the treatment of elderly complete dentures, the modified closed-mouth impression obtains a good application effect in high treatment safety. This therapeutic method has clinical promotion and practical value. 2021 Vol. 28 (12): 130-132转136 [Abstract] ( 63 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 133 Clinical analysis of enamel decalcification in the application of fixed orthodontic appliances YU Peng1 CHEN Ming2 Objective To explore the clinical effect of enamel decalcification in the application of fixed orthodontic appliances. Methods The clinical data of 60 patients who were treated with fixed orthodontic appliances in Fushun Stomatological Hospital from January 2018 to January 2019 were analyzed retrospectively. The number of demineralized teeth, demineralized rate, demineralized degree and demineralized index of enamel in the whole and different positions were observed, and patients were divided into groups according to different brushing frequency during the treatment. The soft scale index and demineralization index of patients under the influence of different brushing frequencies before and after treatment were compared. Results Among 60 patients (1326 teeth), enamel demineralization was found in 41 patients (137 teeth), the incidence rate was 68.33%, the demineralization rate was 10.33%, and the average demineralization index was (0.033±0.024). The degree of demineralization was grade 0, 1189 (89.82%), grade 1, 87 (6.56%), grade 2, 41 (3.09%) and grade 3, 9 (0.53%). Before treatment, there was no significant difference between the soft scaling index and demineralization index of patients with different brushing frequency (P＞0.05). After treatment, the soft scaling index and demineralization index of patients with brushing frequency ≥3 times were lower than those with brushing frequency ＜3 times, the differences were statistically significant (P＜0.05). Conclusion There is a high incidence of enamel demineralization during the application of orthodontic fixed appliances, especially at the location of incisors.Clinical attention should be paid to the enamel demineralization at relevant locations, and prevention and treatment should be done. 2021 Vol. 28 (12): 133-136 [Abstract] ( 45 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 137 Application effect of statins before first thrombolysis in patients with acute ischemic stroke LI Chang KONG De-qian WANG Lin Objective To analyze the clinical effect of statins before thrombolysis for the first time in acute ischemic stroke. Methods From February 2018 to January 2020, a total of 140 patients with acute ischemic stroke in Department of Neurology of Yangchun People′s Hospital were selected and divided into a control group and a study group according to random envelope method, each had 70 cases. The control group did not implement statins before the first thrombolysis, while the study group received statins before the first thrombolysis. The blood lipids, matrix metalloproteinase-9 levels and short-term prognosis of the two groups were compared. Results After treatment, the levels of triglyceride,total cholesterol and low-density lipoprotein cholesterol in the study group were lower than those in the control group,the differences were statistically significant (P＜0.05); the level of high-density lipoprotein cholesterol in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in the level of matrix metalloproteinase-9 between the two groups before treatment(P＞0.05); at 6, 12, 24 and 72 h after treatment, the levels of matrix metalloproteinase-9 in the two groups were higher than those before treatment, and the differences were statistically significant(P＜0.05); at 6, 12, 24 and 72 h after treatment, the levels of matrix metalloproteinase-9 in the study group were lower than those in the control group, and the differences were statistically significant (P＜0.05). There was no significant difference in the good prognosis rate of thrombolysis for 7 days and 90 days between the two groups (P＞0.05). Conclusion The effect of statins before thrombolysis for the first time in acute ischemic stroke is significant, which can improve the level of blood lipid, inhibit the level of matrix metalloproteinase-9, with significant clinical value. 2021 Vol. 28 (12): 137-139转143 [Abstract] ( 51 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 140 Clinical effect of Levofloxacin Lactate and Sodium Chloride Injection in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease PENG Yan Objective To investigate the clinical effect of Levofloxacin Lactate and Sodium Chloride Injection in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 60 elderly AECOPD patients who were treated in Pingxiang Hospital of Traditional Chinese Medicine from November 2018 to October 2019 were selected as the research objects, according to the random number table method,they were divided into two groups, 30 cases in each group. The control group received Piperacillin Sodium Tazobactam Injection, the observation group received Piperacillin Sodium Tazobactam combined with Levofloxacin Lactate and Sodium Chloride Injection. The curative effect, the levels of superoxide dismutase (SOD) and malondialdehyde (MDA),the changes of pulmonary function and the incidence of adverse reactions were observed. Results The total effective rate of treatment in the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05); the recurrence rate of treatment in the observation group was lower than that of the control group,and the difference was statistically significant(P＜0.05). The MDA level in the observation group after treatment was lower than that before treatment and in the control group, the differences were statistically significant(P＜0.05); the level of SOD in the observation group after treatment was higher than that before treatment and in the control group, the differences were statistically significant (P＜0.05). After treatment, FEV1, FVC and FEV1/FVC of the two groups were higher than those before treatment, the differences were statistically significant (P＜0.05); the levels of FEV1, FVC and FEV1/FVC in the observation group were higher than those in the control group, the differences were statistically significant(P＜0.05). The incidence rates of adverse reactions such as abdominal pain/diarrhea, sleepiness/insomnia, pruritus, crystal urine and joint pain between the two groups were compared, the differences were not statistically significant (P＞0.05). Conclusion Levofloxacin Lactate and Sodium Chloride Injection in the treatment of elderly patients with AECOPD can better improve the treatment effect, reduce the recurrence rate, improve the level of SOD and MDA, pulmonary function changes of patients, without increasing the adverse reactions of patients, and has high application value. 2021 Vol. 28 (12): 140-143 [Abstract] ( 47 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 144 Effect of Tirofiban Hydrochloride in the treatment of coronary heart disease CHENG Qian-kun Objective To explore the effectiveness of Tirofiban Hydrochloride in the treatment of coronary heart disease.Methods A total of 88 patients with coronary heart disease admitted to the Iron Coal General Hospital of Liaoning Health Industry Group from June 2018 to June 2020 were selected as the research objects. They were divided into a control group (44 cases) and a test group (44 cases) by the odd and even number grouping method. The control group used conventional treatment, and the test group was treated with Tirofiban Hydrochloride on the basis of conventional treatment. The treatment efficiency, cardiac function, homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP)levels and the rate of adverse events were compared between the two groups. Results The total effective rate of the test group was higher than that of the control group, the difference was statistically significant (P＜0.05). After treatment, the output per minute, ejection fraction and stroke volume of the test group were higher than those of the control group, the differences were statistically significant (P＜0.05). The levels of Hcy and hs-CRP in the test group were lower than those in the control group, the differences were statistically significant (P＜0.05). The total incidence rate of adverse events in the test group was lower than that in the control group, the difference was statistically significant (P＜0.05).Conclusion Tirofiban Hydrochloride in the treatment of coronary heart disease can significantly improve the clinical efficacy, improve heart function, reduce the body′s inflammatory reaction, and reduce the occurrence of adverse events. 2021 Vol. 28 (12): 144-146 [Abstract] ( 47 ) HTML (29 KB)  PDF  (0 KB)  ( 7 ) 147 Effect of abnormal thyroid function on negative emotion of spontaneous preterm delivery LI Ning1 FENG Ling2 ZHOU Zhou1 Objective To investigate the effect of abnormal thyroid function on negative emotion of spontaneous premature parturient. Methods A total of 98 cases of spontaneous preterm delivery in Xinfeng County People′s Hospital from January 2016 to December 2019 were selected. Free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) were detected postpartum. The Hamilton depression scale (HAMD)-24 items and the Hamilton anxiety scale (HAMA) were used to assess negative emotions. The HAMD and HAMA scores of patients with normal and abnormal FT3, FT4 and TSH were compared, the influence of abnormal thyroid function on anxiety and depression was analyzed. Results There were no statistical significances in HAMD and HAMA scores of spontaneous preterm parturiums with normal and abnormal FT3 and FT4 levels (P＞0.05). HAMD and HAMA scores of spontaneous preterm parturials with abnormal TSH were higher than those with normal TSH, and the differences were statistically significant (P＜0.05). There was no statistical significance in the detection rate of depression and anxiety between abnormal FT3 and FT4 levels and normal levels of spontaneous preterm delivery (P＞0.05). The detection rates of depression and anxiety in spontaneous preterm parturiums with abnormal TSH level were higher than those in normal TSH group, with statistical significances (P＜0.05). Conclusion TSH is an influential factor for the negative emotions of spontaneous preterm delivery women, and the women with abnormal spontaneous preterm delivery are more likely to have anxiety and depression.It should arouse the clinician′s attention, early attention and prevention, to carry on the targeted psychological counseling and intervention. 2021 Vol. 28 (12): 147-149转153 [Abstract] ( 40 ) HTML (34 KB)  PDF  (0 KB)  ( 9 ) 150 Clinical effect of quality control before the application of urine routine clinical test DENG Xian-ping Objective To analyze the effect of quality control before the application of routine clinical testing of urine.Methods A total of 300 patients who underwent routine urine examination in the No.8 Medical Center, General Hospital of Chinese PLA laboratory medicine department from March 2019 to March 2020 were selected as the research subjects. The patients were divided into the control group (150 cases) and the experimental group (150 cases) according to the random number table method. The control group used the traditional quality management mode for routine urine test, and the experimental group used pre analysis quality control. The qualified rate of routine urine specimens, the quality of routine urine examination, the satisfaction of doctors and patients were compared between the two groups,and the reasons for unqualified routine urine specimens were analyzed. Results The passing rate of routine urine specimens in test group was higher than that in control group, and the difference was statistically significant (P＜0.05). The total score of urine routine test and the quality scores of environment, technology and personnel in experimental group were higher than those in control group, the differences were statistically significant (P＜0.05). The satisfaction of routine urine test was higher in the experimental group than in the control group, and the difference was statistically significant (P＜0.05). The main reasons for unqualified samples were contamination of samples, wrong collection and small sample size. Conclusion The application of pre-analytical quality control of urine routine clinical testing can improve the sample qualification rate and test quality, and has the value of popularizing. 2021 Vol. 28 (12): 150-153 [Abstract] ( 43 ) HTML (36 KB)  PDF  (0 KB)  ( 5 ) 154 Analysis of the surveillance results of carbapenem-resistant Enterobacteriaceae drug resistance in Huludao Central Hospital from 2017 to 2019 ZHANG Man-jia Objective To analyze the monitoring resistance results of carbapenem-resistant Enterobacteriaceae in Huludao Central Hospital. Methods The carbapenem Enterobacteriaceae bacteria detection, distribution and drug resistance were tested using EDTA collaborative test, modified Hodge test, Kirby-Bauer method (KB method) combining with Phoenix-100 full-automatic bacterial identification/drug susceptibility system in Huludao Central Hospital from January 2017 to December 2019. Results From January 2017 to December 2019, a total of 9220 strains of Enterobacteriaceae bacteria were isolated, of which 510 were carbapenem Enterobacteriaceae, and the total detection rate was 5.53% (510/9220). The three-year detection rates in 2017, 2018, and 2019 were 32.55%(166/510), 34.51%(176/510)and 32.94%(168/510), respectively, and the difference was not statistically significant (P>0.05). Among 510 carbapenem Enterobacteriaceae, the main specimen was sputum, accounting for 74.90% (382/510). The other specimen sources were 3 strains from pleural fluid specimens (0.59%), 5 from bile specimens (0.98%), 7 from secretions specimens (1.37%), 9 from ascites specimens (1.76%), 11 strains from drainage fluid specimens (2.16%), 20 strains from urine specimens(3.92%), 22 strains from catheter tip specimens (4.31%), 51 from blood specimens (10.00%). From 2017 to 2019, the bacterial strains of carbapenem Enterobacteriaceae resisted against the commonly used antibacterial drugs such as Meropenem, Imipenem, Aztreonam, Cefepime, Cefotaxime, Ceftazidime, Cefazolin, Piperacillin/Trizobacte, and Cefoperazone/Sulbactam. The strains were sensitive to Tigecycline and polymyxin. Conclusion The infection rate of carbapenem Enterobacteriaceae in the hospital is relatively high. The most common strain is Klebsiella pneumoniae, which is resistant to most antibacterial drugs. It is resistant to Tigecycline, Polymyxin, Cotrimoxazole, Amikacin, and Gentamicin to a certain degree. When choosing drugs in clinic, the corresponding antibacterial drugs should be selected based on the actual situation. 2021 Vol. 28 (12): 154-156转160 [Abstract] ( 40 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 157 Thinking on strengthening the construction of CPC branches in medical research institutes in the new era HU Li-lei YU Xiao-xiao WANG Ying SUN Bo JIA Shu-ying▲ Medical research institutes are important platforms for medical research and health care course. The construction of CPC branches is an important part of CPC organizational construction in medical research institutes.Strengthening the construction of CPC branches in such institutes and promoting the effective integration of scientific research and CPC Party building is of great and far-reaching significance for deepening the reform of medical and health system, facilitating the construction of healthy China, and promoting the innovation of medical research. 2021 Vol. 28 (12): 157-160 [Abstract] ( 36 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 161 Study on application of ABCD classification management to improve stock turnover rate of Chinese herbal pieces ZHA Hong-qun WU Qi HU Jing-ting YANG Wen-hua ZHA Nan-hui Objective To apply the ABCD classification management to improve the stock turnover rate and inventory management efficiency of traditional Chinese herbal pieces. Methods By the ABCD classification, traditional Chinese herbal pieces in Jiujiang First People′s Hospital were divided into four categories: A, B, C, and D according to the cumulative percentage of the amount of ex-warehouse. They were performed with classification management based on different levels to formulate different purchase quantities and purchase frequencies. The stock turnover rates before and after the implementation of the ABCD classification, that is, from January to December 2018 and the same period in 2019 were compared. Results After adopting the ABCD classification method for inventory management, the monthly stock turnover rate in 2019 was higher than that in the same period in 2018. The average monthly stock turnover rate in 2019 was 1.44 times that of 2018. Conclusion The ABCD classification can effectively improve the stock turnover rate of traditional Chinese medicine warehouse and reduce the value of circulating funds occupied by these herbs. 2021 Vol. 28 (12): 161-163 [Abstract] ( 31 ) HTML (28 KB)  PDF  (0 KB)  ( 6 ) 164 Application of standardized management of integrated medical care in prevention of deep vein thrombosis after orthopedic surgery LIU Ping Objective To explore the application value of integrated standardized management of medical care in the prevention of deep vein thrombosis (DVT) after orthopedic surgery. Methods A total of 120 patients with major orthopedic surgery in Jingdezhen Second People′s Hospital from July 2018 to April 2020 were selected as research objects and divided into the control group and the study group according to the different nursing management modes. The control group adopted the routine nursing management mode, and the study group adopted the standardized management mode of integrated medical care. The incidence of deep venous thrombosis, postoperative hospitalization days, nursing satisfaction and nursing compliance rate were compared between the two groups. Results The incidence of DVT in the study group was lower than that in the control group, the postoperative hospital stay was shorter than that in the control group, and the compliance and satisfaction of the study group were higher than those of the control group, the differences were statistically significant (P＜0.05). Conclusion The application of standardized nursing management mode to patients undergoing orthopedic surgery can effectively reduce the incidence of DVT, shorten the days of hospitalization after operation, improve the nursing compliance and nursing satisfaction of patients, which is worthy of clinical application. 2021 Vol. 28 (12): 164-167 [Abstract] ( 45 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 168 Effect of project management and exercise management mode in elderly patients with chronic obstructive pulmonary disease CHEN Wan-nian Objective To explore the effect of project management and exercise management mode in elderly patients with chronic obstructive pulmonary disease. Methods A total of 70 elderly patients with chronic obstructive pulmonary disease admitted to Loudi Central Hospital from January 2019 to March 2020 were selected as the research objects. According to random number table method, they were divided into control group and research group, with 35 cases in each group. The control group was treated with routine management mode, and the research group was treated with project management mode on that basis. Respiratory function and exercise tolerance were compared between the two groups.Results Before intervention,there were no significant differences in forced vital capacity(FVC),vital capacity (VC), peak expiratory flow (PEF), maximal mid-expiratory flow curve (MMEF), forced expiratory volume in the first second (FEV1)and FEV1/FVC levels between the two groups (P＞0.05). After intervention, the levels of FVC, VC, PEF, MMEF, FEV1 and FEV1/FVC in the two groups were all higher than those before intervention, the differences were statistically significant (P＜0.05). After intervention, the levels of FVC, VC, PEF, MMEF, FEV1 and FEV1/FVC in the research group were all higher than those in the control group, the differences were statistically significant (P＜0.05). Before intervention,there were no significant differences in 6 min walking distance (6MWD), VO2 Max and exercise time when reaching anaerobic threshold (AT) between the two groups (P＞0.05). After intervention, 6MWD and VO2 Max in the two groups were higher than those before intervention, exercise time to AT in the two groups was longer than that before intervention, the differences were statistically significant (P＜0.05); after intervention, 6MWD, VO2 Max in the research group were higher than those in the control group, exercise time to AT in the research group was longer than that in the control group, the differences were statistically significant (P＜0.05). Conclusion The application of project management and exercise management mode in elderly patients with chronic obstructive pulmonary disease can effectively improve exercise tolerance and respiratory function. 2021 Vol. 28 (12): 168-171 [Abstract] ( 34 ) HTML (35 KB)  PDF  (0 KB)  ( 5 ) 172 Application effect of PDCA cycle management in nursing of fever clinic LI Li-na LI Rui Objective To investigate the effect of plan-do-check action (PDCA) cycle management in the nursing of fever clinics. Methods A total of 51 patients with fever admitted to the outpatient clinic of the Department of Infectious Diseases, Beijing Aerospace General Hospital from June to December 2018 were selected as the reference group, who were treated with routine nursing intervention. In addition, a total of 51 patients with fever admitted to the outpatient clinic of the Department of Infectious Diseases, Beijing Aerospace General Hospital from January to June 2019 were selected as the study group, who were treated with management. The scores of basic nursing quality, nursing document quality, and professional nursing, and nursing satisfaction of the two groups were compared. Results The scores of basic nursing quality, nursing document quality and professional nursing quality of the study group were higher than those of the reference group, and the differences were statistically significant (P＜0.05). The nursing satisfaction of the study group was higher than that of the reference group, and the difference was statistically significant (P＜0.05). Conclusion The application effect of PDCA cycle management in the nursing of fever clinics has won the favor of most patients,and meanwhile it promotes the improvement of the professional quality of nursing staff, which is worth promoting. 2021 Vol. 28 (12): 172-174 [Abstract] ( 44 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 175 Application value of continuous quality improvement cycle program mode in risk management of postoperative pulmonary infection in patients with craniocerebral surgery ZHANG Ning-si1 JIANG Li2 HE Huan3 Objective To explore the application of continuous quality improvement cycle (FOCUS-PDCA) program model in postoperative lung infection risk management of patients undergoing craniocerebral surgery. Methods A total of 88 patients who underwent craniocerebral surgery from January 2018 to September 2020 in Pingxiang Third People′s Hospital were selected and divided into control group (n=43) and observation group (n=45) according to the difference in management mode during the treatment process. The patients in the control group were given conventional nursing mode after surgery, and the patients in the observation group were managed according to 9 steps in the Focus-PDCA procedure mode. The incidence of postoperative pulmonary infection, duration of infection, catheter insertion time, ICU observation time and total hospital stay of the two groups were compared, and the nursing satisfaction of the two groups in the treatment process was compared. Results The incidence of postoperative pulmonary infection in the observation group was lower than that in the control group, the duration of infection in the observation group, tube-in-tube time,ICU observation time and total hospitalization time were shorter than the control group, and the differences were statistically significant (P＜0.05). The nursing satisfaction rate of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion The FOCUS-PDCA program mode can significantly reduce the incidence of pulmonary infections in patients undergoing craniocerebral surgery, shorten the time of catheterization, ICU observation time, and hospital stay, promote patient recovery, and improve patient satisfaction with treatment. 2021 Vol. 28 (12): 175-178 [Abstract] ( 38 ) HTML (38 KB)  PDF  (0 KB)  ( 5 ) 179 Application effect of PDCA circulation management mode in blood station nursing ZOU Dan-li Objective To investigate the application effect of PDCA circulation management model in blood station nursing work. Methods A total of 400 unpaid blood donors from April to October 2019 in Nanping Central Blood Station were selected as the research objects. According to the time sequence of blood donation, they were divided into control group and observation group, with 200 cases in each group. The control group was given routine management,and the observation group was given PDCA cycle management mode. The comfort level, nursing quality, nursing satisfaction of unpaid blood donors and the success rate of blood donation were compared between the two groups. Results After intervention, the comfort score of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The nursing quality scores of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). The total nursing satisfaction of unpaid blood donors in the observation group was higher than that in the control group, and the difference was statistically significant (χ2=4.581, P=0.032). The success rate of blood donation in the observation group was higher than that in the control group, and the difference was statistically significant (χ2=4.092, P=0.043). Conclusion The PDCA circulation management model has significant effect in the nursing work of blood stations, which can improve the comfort of blood donors, nursing satisfaction, blood donation success rate, and improve the nursing quality of nursing staff. 2021 Vol. 28 (12): 179-181转185 [Abstract] ( 44 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 182 Application study of objective structured clinical examination in the prepractice training of nursing undergraduates XIANG Ting-ting1 JIANG Xiao-jian1▲ LI Qiong1 HAN Ping2 HU Jin-ling1 Objective To explore the application effect of objective structured clinical examination (OSCE) in the prepractice training of nursing undergraduates. Methods A total of 60 undergraduate nursing students from the School of Nursing of Hu′nan University of Chinese Medicine in 2017 were selected as the research objects. They were divided into observation group and control group according to the principle of simple random grouping, with 30 students in each group. The observation group received OSCE training before practice, and the control group received routine training before practice. The assessment results and attitudes towards assessment mode were compared in the two groups. Results The scores of nursing evaluation, clinical thinking, basic skills operation, first-aid skills operation and humanistic nursing communication in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). The acceptance rate of nursing students in the observation group was higher than that in the control group, including reasonable setting of assessment structure, reflection and improvement of occupational comprehensive ability, internship position, adaptability and identity of the assessment mode, with statistically significant differences (P＜0.05). Conclusion Setting up OSCE is conducive to improving the clinical practice ability of nursing students,better promoting nursing students to adapt to clinical working mode. 2021 Vol. 28 (12): 182-185 [Abstract] ( 49 ) HTML (33 KB)  PDF  (0 KB)  ( 5 ) 186 Teaching design of Pharmaceutical Analysis based on PDA class teaching mode CAO Yu-pin1 WEI Zhi-ying2 QIN Hua-zhen1 PAN Xiao-jiao1▲ Taking analysis of traditional Chinese medicine preparations as an example, the teaching practice of Pharmaceutical Analysis was carried out and the teaching design for cultivating students′ autonomous learning ability was discussed by using PDA class. In the process of teaching, three class discussion questions and one class assignment were designed according to the key points and difficulties in this chapter. In the teaching evaluation, group and individual classroom performance items were set up to encourage students to study actively. Reasonable teaching design and effective class evaluation were the two key factors to make good use of the PDA class. 2021 Vol. 28 (12): 186-188转192 [Abstract] ( 43 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 189 Influence of situation cognitive change based on hybrid synchronous teaching on the learning effect LIU Wen-yao1 BAO Hong-guang2 JIN Xiao-qiu3 WANG Xiao-juan1 LI Jing-long2▲ Objective To analyze the influence of situation cognitive change based on hybrid synchronous teaching on the learning effect. Methods A total of 175 undergraduate students majoring in clinical medicine in Qiqihar Medical University at the first semester of their senior year from February to July 2020 were selected as the observation group,and 178 undergraduate students majoring in clinical medicine in Qiqihar Medical University at the first semester of their senior year from February to July 2019 were selected as the control group. The observation group was given hybrid synchronous teaching, while the control group was given traditional teaching. The students′ final scores in the main subjects and learning were compared between the two groups, and after the final exam, a self-made questionnaire was used to investigate the students′ satisfaction with the teaching situation. Results There were no statistically significant differences in the final scores and average score of the main subjects between the two groups (P＞0.05). The learning initiative and time management ability of the observation group were higher than those of the control group, and the classroom learning efficiency and interpersonal communication ability were lower than those of the control group, the differences were statistically significant (P＜0.05). There were no statistically significant differences in learning interest,technical operation ability, autonomous learning ability, language expression ability, communication ability, critical thinking ability,discovery and problem-solving ability between the two groups(P＞0.05).There were no statistically significant differences in students on satisfaction with teaching support, teaching competency, teaching efficiency, teaching process, teaching environment and overall satisfaction between the two groups (P＞0.05). Conclusion Based on the situation of hybrid synchronous teaching, situation cognitive change has no obvious effect on students′ performance and satisfaction with teaching situation, but it can improve students′ learning initiative and time management ability. 2021 Vol. 28 (12): 189-192 [Abstract] ( 51 ) HTML (33 KB)  PDF  (0 KB)  ( 9 ) 193 Effect analysis of video education in elderly patients with lung function examination CUI Hong1 YU Hong2 WANG Xiao-xi3▲ Objective To study the application effect of video education in pulmonary function examination of elderly patients. Methods A total of 130 elderly patients with lung function examination who were admitted to Dalian Port Hospital from March 2019 to March 2020 were selected as the research objects. By random number table method, the patients were divided into experimental group and reference group, with 65 cases in each group. Before the pulmonary function examination, patients in the reference group received the routine publicity and education of pulmonary function examination through health manual and operation demonstration, while patients in the experimental group received the routine publicity and education combined with multimedia video publicity and education. The time required to complete the pulmonary function examination, the completion rate of the pulmonary function examination and the quality of the examination results were compared between the two groups. Results The time required to complete lung function examination in experimental group was shorter than that in control group, and the difference was statistically significant (P＜0.05). The completion rate of pulmonary function examination in experimental group was higher than that in reference group, and the difference was statistically significant (P＜0.05). The quality of lung function examination results in experimental group was better than that in the reference group, and the difference was statistically significant (P＜0.05).Conclusion The health education of lung function examination in elderly patients can help patients to complete the examination better, improve the degree of completion of the examination, shorten the time of examination, and improve the quality of the examination results. 2021 Vol. 28 (12): 193-195 [Abstract] ( 42 ) HTML (31 KB)  PDF  (0 KB)  ( 5 ) 196 Application of health education based on transtheoretical model in pulmonary rehabilitation follow-up management of patients with chronic obstructive pulmonary disease LIANG Xia-ying1 OUYANG Li2 LI Pei-qi2 Objective To explore the application effect of health education based on transtheoretical model in pulmonary rehabilitation follow-up management of patients with chronic obstructive pulmonary disease (COPD). Methods A total of 80 COPD patients who were admitted to the Ninth People′s Hospital of Nanhai District, Foshan City from February 2019 to January 2020 and were about to be discharged due to improved condition were selected as the research subjects. According to the random number table method, they were divided into observation group and control group, with 40 cases in each group. The control group received routine health education, while the observation group received health education based on cross-theoretical model. The level of disease self-management, lung function and quality of life were compared between the two groups before intervention and 3 and 6 months after intervention. Results The scores of self-management level and each dimension of quality of life, forced expiratory volume in first second(FEV1), FEV1/forced vital capacity (FEV1/FVC) and the percentage of FEV1 in the estimated values (FEV1%pred) of patients in the observation group were higher than those before intervention, and higher than those in the control group,the differences were statistically significant (P＜0.05). Conclusion Health education based on transtheoretical model can effectively improve the disease self-management ability of COPD patients, promote the rehabilitation of lung function and improve the quality of life. 2021 Vol. 28 (12): 196-199 [Abstract] ( 45 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 200 Application of picture based dialogue tool based on empowerment theory in primary insulin treatment for elderly patients with diabetes ZHENG Cai-mei ZHANG Yu-ping Objective To explore the application of picture based dialogue tool based on empowerment theory in primary insulin treatment for elderly patients with diabetes. Methods A total of 186 elderly patients with diabetes who were admitted to Huidong People′s Hospital from February 2017 to October 2019 were selected as the research subjects.According to the random envelope method,they were divided into study group (93 cases)and control group (93 cases). The control group received routine education, while the study group received the picture dialogue tool education based on empowerment theory. The living habits, behavioral changes, metabolic indicators and diabetes knowledge cognition score after education were compared between the two groups. Results After education, the proportions of patients in the study group who adhered to exercise, took drugs according to the doctor′s advice, regularly checked their blood glucose,quit smoking and drinking, reasonable diet, and regularly reviewed were higher than those in the control group, the differences were statistically significant (P＜0.05). After education, the levels of serum total cholesterol, triglyceride, diastolic blood pressure, glycosylated hemoglobin, postprandial 2 h blood glucose and fasting blood glucose in the study group were lower than those in the control group, the differences were statistically significant (P＜0.05). After education,the scores of insulin use, diabetes comprehensive management skills and complications knowledge in the study group were higher than those in the control group, the differences were statistically significant (P＜0.05). Conclusion For elderly patients with diabetes mellitus, in the first treatment, the implementation of the authorization theory based on the picture dialogue tool education, can improve bad habits and behaviors, improving metabolic indicators, raising patients′knowledge of disease, it has remarkable clinical value. 2021 Vol. 28 (12): 200-202转206 [Abstract] ( 45 ) HTML (32 KB)  PDF  (0 KB)  ( 5 ) 203 Influence of interactive health education nursing on children with pneumonia WEI Li-ling Objective To explore the effect of interactive health education and nursing on children with pneumonia.Methods A total of 80 children with pneumonia admitted to the First People′s Hospital of Fuzhou City in Jiangxi Province from March 2018 to April 2020 were selected as the research objects and they were divided into the control group and the observation group by random number table method, with 40 cases in each group. Children of two groups were given ultrasound atomization, the control group was given routine nursing, the observation group was treated with interactive health education nursing. The disappearance time of clinical symptoms of pulmonary rales, shortness of breath and cyanosis, recurrence rate and total effective rate of nursing were compared between the two groups. Results The disappearance time of pulmonary rales, shortness of breath and cyanosis in the observation group was shorter than that in the control group, the differences were statistically significant (P＜0.05). The recurrence rate in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). The total effective rate of nursing in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). Conclusion The implementation of interactive health education nursing in children with pneumonia has good application effect. 2021 Vol. 28 (12): 203-206 [Abstract] ( 47 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 207 Influence of health education on the knowledge level of children with enteritis OUYANG Yu-yu Objective To explore the application value of health education in the nursing of children with enteritis.Methods A total of 42 children with enteritis admitted to Quanzhou Women′s and Children′s Hospital from May 2019 to April 2020 were selected as the research objects. According to random number table method, they were divided into the control group and the observation group, with 21 cases in each group. The control group was given routine nursing methods and the observation group was given health education methods. The knowledge level, psychological state and nursing satisfaction of family members of the two groups on enteritis were compared. Results After intervention, the degree of knowledge about enteritis in observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The scores of anxiety and depression in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The nursing satisfaction score of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion Health education can effectively improve the mental state of family members and enhance their understanding of enteritis disease knowledge. It is recommended that clinical practice be carried out widely. 2021 Vol. 28 (12): 207-209 [Abstract] ( 43 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 210 Influence of high quality nursing intervention on blood pressure of patients with white coat hypertension YANG Jian1 HUANG Su-lan2▲ Objective To explore the influence of high quality nursing intervention on blood pressure of hypertensive patients with white coat. Methods A total of 140 patients with white-coat hypertension were selected in the First People′s Hospital of Changde City in Hu′nan Province from January 2015 to December 2019. The 1∶1 nearest neighbor matching method was used to match the propensity of the two groups of patients to control the influence of confuses.The control group (n=70) received general health education, and the study group (n=70) received high-quality nursing intervention on the basis of health education. The nursing effect of the two groups was compared. Results After intervention, systolic blood pressure and diastolic blood pressure of patients in the study group were lower than those in the control group, and the differences were statistically significant (P＜0.05). There were no significant differences in systolic and diastolic blood pressure at 24 h, day and night between the two groups (P＞0.05). Conclusion High quality nursing intervention can improve the blood pressure level of patients with white coat hypertension. 2021 Vol. 28 (12): 210-212转216 [Abstract] ( 42 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 213 Application effect of structured nursing program in preventing medical adhesive-related skin injury in ICU patients FANG Lan HU Jing LI Dong-ying Objective To explore the application effect of structured nursing program to prevent medical adhesive-related skin injury (MARSI) in intensive care unit (ICU) patients, continuously improve the quality of clinical skin care,and prevent MARSI. Methods Forty-five ICU patients who used medical adhesive products in the Second Affiliated Hospital of Nanchang University before the launch of the structured nursing program from March 2018 to March 2019 were selected as the control group. Another batch of 45 ICU patients who used medical adhesive products in the Second Affiliated Hospital of Nanchang University was enrolled as the observation group after carrying out the structured nursing program from April 2019 to March 2020. The nursing satisfaction, MARSI type and incidence of the two groups after intervention were compared. Results After the intervention, the incidence rates of tension injury, exfoliation, and capsulitis in the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). After the intervention, the incidence of MARSI in the observation group was lower than that of the control group, with statistical difference (P＜0.05). The patients′ total satisfaction of the observation group was higher than that of the control group after intervention, and the difference was statistically significant (P＜0.05). Conclusion The structured nursing treatment for ICU patients has certain clinical application value in reducing the occurrence of MARSI in ICU patients with MARSI, and has a positive effect on significantly improving the clinical effects of patients. 2021 Vol. 28 (12): 213-216 [Abstract] ( 45 ) HTML (34 KB)  PDF  (0 KB)  ( 9 ) 217 Application effect of 6A nursing mode in patients performed with enhanced CT scan ZENG Lan-ying Objective To explore the application effect of 6A nursing mode in improving patients with enhanced CT scan. Methods A total of 430 patients who underwent enhanced CT scan in Jiangxi Maternal and Child Health Hospital from January to December 2018 were selected as research subjects. They were divided into the control group and the experimental group by random number table method, 215 cases in each group. In the control group, conventional nursing measure was adopted, and in the experimental group, the 6A nursing model on this basis was adopted. The total incidence of adverse reactions, anxiety symptoms, and nursing satisfaction between the two groups after intervention were compared. Results After nursing, the total incidence of adverse reactions of the experimental group was lower than that of the control group, and the self-rating anxiety scale (SAS) score was lower than that of the control group, and the differences were statistically significant (P＜0.05). In the experimental group, patients′ total satisfaction on service attitude,service measures, professional skills, work flow, waiting time, and health education was better than that in the control group, with statistical differences (P＜0.05). Conclusion The 6A nursing mode reduces the incidence of adverse reactions in patients undergoing enhanced CT scanning, and improves anxiety symptoms and nursing satisfaction. 2021 Vol. 28 (12): 217-220 [Abstract] ( 51 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 221 Application effect of rehabilitation therapeutic instrument combined with pelvic floor training in postpartum rehabilitation nursing of primipara YAO Shui-lian Objective To explore the application effect of rehabilitation therapy instrument combined with pelvic floor training in postpartum rehabilitation nursing of primipara. Methods A total of 98 cases of primipara who were admitted to Jingdezhen Maternal and Child Health Hospital in Jiangxi Province from May 2018 to March 2020 were selected as the research objects. According to the odd-even method, they were divided into the control group (49 cases) and the observation group (49 cases). The control group received conventional nursing and the observation group used rehabilitation therapy instrument combined with pelvic floor training. The quality of life， sleep quality, mental state score,complication rate, and postpartum recovery time were compared between the two groups. Results The time of lochial,the time of first urination, and the time of lactation of the observation group were shorter than those of the control group, the differences were statistically significant (P＜0.05). Before the intervention, the self-rating anxiety scale (SAS)and self-rating depression scale (SDS) scores of two groups, the differences had no statistical significance (P＞0.05)； after the intervention, the SAS and SDS scores of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). Before the intervention, the quality of life scores of the two groups were not significantly different (P＞0.05); the quality of life score of the observation group after the intervention was higher than that of the control group, and the difference was statistically significant (P＜0.05). The total incidence of complications in the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The application of rehabilitation therapy instrument combined with pelvic floor training in postpartum rehabilitation nursing of primipara can effectively shorten the postpartum rehabilitation time, improve the patients′ quality of life and negative emotional state, and control the incidence of complications. It is worthy of popularization and application. 2021 Vol. 28 (12): 221-224 [Abstract] ( 57 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 225 Effect of multi-dimensional crisis control nursing on the coping style and mental health of patients with acute cholecystitis surgery WU Cai-ling Objective To explore the impact of multi-dimensional crisis control nursing on the coping style and mental health of patients with acute cholecystitis surgery. Methods A total of 80 patients who underwent acute cholecystitis surgery in Fuzhou First People′s Hospital in Jiangxi Province from January 2017 to March 2020 were selected and divided into two groups by random number table method, 40 cases in each group. The control group received routine nursing, and the observation group received multi-dimensional crisis control nursing. The psychological status and coping styles of the two groups were compared. Results Compared self-rating anxiety scale (SAS), self-rating depression scale (SDS) scores, facing, avoiding, and yielding scores of the two groups before nursing, the differences were not statistically significant (P＞0.05)； after nursing, the SAS, SDS, avoidance and yield scores of the observation group were lower than those of the control group, and the face score of the observation group was higher than that of the control group, and the differences were statistically significant (P＜0.05). Conclusion Multi-dimensional crisis control nursing for patients with acute cholecystitis surgery can improve their psychological status and coping styles, and is worthy of use. 2021 Vol. 28 (12): 225-227 [Abstract] ( 44 ) HTML (28 KB)  PDF  (0 KB)  ( 6 ) 228 Application effect of pre-hospital emergency nursing intervention in patients with chest pain WANG Ting Objective To study the application effect of pre-hospital emergency nursing in patients with chest pain.Methods A total of 72 patients with chest pain admitted to Shangrao People′s Hospital in Jiangxi Province from May 2018 to March 2019 were selected as the research subjects. They were divided into the routine group (n=36) and the intervention group (n=36) by random number table method. In the routine group, no nursing was provided before admission, while in the intervention group, pre-hospital emergency nursing intervention was adopted before admission.The total incidence of complications, mortality, and emergency status of the two groups were compared. Results After the pre-hospital emergency nursing intervention in the intervention group, the diagnosis time, treatment time and hospital stay of the patients were shorter than those in the routine group, the differences were statistically significant (P＜0.05). The total incidence of complications and mortality in the intervention group were lower than those of the routine group, the differences were statistically significant (P＜0.05). Conclusion Pre-hospital emergency nursing intervention is better than conventional nursing and treatment for patients with chest pain. Patients can be effectively treated in a short time, and the total incidence of complications and mortality have decreased. 2021 Vol. 28 (12): 228-230 [Abstract] ( 41 ) HTML (29 KB)  PDF  (0 KB)  ( 7 ) 231 Effect of perioperative targeted nursing intervention on recovery of ureteroscopic lithotripsy patients LIU Cui-lian Objective To investigate the effect of perioperative targeted nursing intervention on the recovery of ureteroscopic lithotripsy. Methods From September 2018 to September 2019, 98 cases of ureteroscopic lithotripsy treated in Beijing Fangshan District Liangxiang Hospital were selected. They were divided into the study group and the routine group using random number table method, 49 cases in each group. Both groups were treated with ureteroscopic holmium laser lithotripsy. Routine nursing was carried out in the routine group during the perioperative period. And the study group received targeted nursing intervention during perioperative period. The time indexes of postoperative recovery were compared and the satisfaction of perioperative nursing were compared between the two groups. Results The time of return to normal, the retention time of urinary catheter and the total length of stay in the study group were shorter than those in the routine group, the differences were statistically significant (P＜0.05). Total satisfaction of perioperative nursing in the study group was higher than that in the conventional group, the difference was statistically significant (P＜0.05). Conclusion Perioperative targeted nursing intervention can play a positive role in postoperative recovery of patients with ureteroscopic lithotripsy. It can promote the return to normal, reduce the number of days in hospital, and improve the satisfaction of patients. 2021 Vol. 28 (12): 231-233 [Abstract] ( 48 ) HTML (28 KB)  PDF  (0 KB)  ( 7 ) 234 Application of family-centered continuous nursing in patients with chronic and difficult-to-heal wounds LU Yan-bing1 ZHANG Xiu-ni2 WU Cui-yi3 Objective To explore the application effect of family-centered continuous nursing in patients with chronic difficult-to-heal wounds. Methods A total of 136 patients with chronic and difficult-to-heal wounds admitted to Guangzhou Panyu District Central Hospital from July 2018 to December 2019 were selected as the research objects,and were divided into the control group (68 cases) and the observation group (68 cases) according to the random number table method. The control group received routine nursing, and the observation group added family-centered continuous nursing. The scores of self-management ability, the rate of return to hospital due to worsening wounds and the nursing satisfaction were compared between the two groups. Results Three months after discharge, the score of selfmanagement ability of the observation group was higher than that in the control group, the rate of return to hospital due to worsening wounds was lower than that in the control group, and the nursing satisfaction score was higher than that in the control group, the differences were statistically significant (P＜0.05). Conclusion Family-centered continuous nursing can improve the self-management ability and nursing satisfaction of patients with chronic difficult-to-heal wounds,reduce the rate of return to hospital due to worsening wounds, improve the rehabilitation effect of patients, and provide a certain basis for the promotion of family nursing measures for chronic and difficult-to-heal wounds. 2021 Vol. 28 (12): 234-236转240 [Abstract] ( 49 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 237 Effect of cognitive belief behavior oriented intervention model on medication compliance and self-management of patients with cerebral aneurysm after operation XU Jia-ling YANG Li CAO Jin CHEN Jing QIAN Xiao-lan ZHOU Chun-xiu XU Wen-mei▲ Objective To explore the effect of cognitive belief behavior oriented intervention model on medication compliance and self-management of patients with cerebral aneurysm after operation. Methods A total of 30 patients with cerebral aneurysms treated in Shanghai Oriental Hospital from January to December 2018 were selected as the control group, and routine nursing was adopted. A total of 30 patients with cerebral aneurysms treated in Shanghai Oriental Hospital from January to December 2019 were selected as the observation group. On the basis of routine nursing, the patients were given cognitive belief behavior oriented intervention mode. The intervention lasted for 3 months after discharge. The medication compliance and self-management level of the two groups were compared. Results The medication compliance of the observation group was better than that of the control group 3 months after discharge, and the difference was statistically significant (P＜0.05). The scores of self-management ability of the observation group were better than those of the control group 3 months after discharge, such as symptom management, emotion management and daily life management, and the differences were statistically significant(P＜0.05).Conclusion The cognitive belief behavior oriented intervention model can improve the medication compliance and self-management ability of patients with cerebral aneurysm after operation. 2021 Vol. 28 (12): 237-240 [Abstract] ( 48 ) HTML (32 KB)  PDF  (0 KB)  ( 9 )

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