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2018 Vol. 25, No. 18
Published: 2018-06-28
 
 
4 Expression of KDM3A in breast cancer and its clinical significance
SUN Dong-yuan;ZHANG Ming-yang;WANG Lan;WU Yi
ObjectiveTo study the difference of the expression of histone demethylation enzyme KDM3A in breast cancer tissue and normal breast tissue and its relationship with clinicopathological characteristics.MethodsThe breast cancer tissues and normal breast tissues used in immunohistochemistry were derived from the Central Hospital Affiliated to Shenyang Medical College.The paraffin specimens of breast cancer were collected from 2013 to 2015,all of which were women.The expression of KDM3A in 100 cases of breast cancers and 30 cases of normal breast tissues was detected by using immunohistochemical SP method.The relationship between the expression of KDM3A and the clinicopathological features of patients′age,estrogen receptor　(ER),progesterone receptor　(PR),tumor stage,tumor size and lymph node metastasis were analyzed.ResultsThe positive rate of KDM3A in breast cancer tissues was 89.0%(89/100),and the positive rate of KDM3A in normal breast tissue was 66.7%　(20/30).The expression of KDM3A in breast cancer was higher than that of normal breast tissue,with statistically significant difference　(P＜0.05).The expression of KDM3A was related to the size of the tumor and the expression of ER.ConclusionThe high expression of KDM3A in breast cancer tissue is related to the size of tumor and the expression of ER,suggesting that KDM3A may play a role in promoting the growth and proliferation of breast cancer in ER-positive breast cancers.
2018 Vol. 25 (18): 4-06 [Abstract] ( 153 ) HTML (35 KB)  PDF  (0 KB)  ( 31 )
7 Intervention effect of β-elemene on the expression of VEGF in the retina of rats with diabetic retinopathy during proliferating phase
SHUAI Tian-jiao;DAI Hai-yan;ZHANG Zhao-di;CHEN Dan-dan;WANG Rui-ying;PIAO Tian-hua
ObjectiveTo observe the effect of β-elemene on the expression of vascular endothelial growth factor(VEGF)in the retina of rats with proliferative diabetic retinopathy caused by streptozocin(STZ),to investigate its possible mechanism of action on retinopathy of rats with proliferative diabetic retinopathy.MethodsA total of 80 Wistar rats were selected.They were randomly divided into normal control group　(NC group),STZ-induced diabetes model group(DC group),low-dose β-elemene group(BL group)and high-dose group(BH group),20 rats in each group.In the administration group,different doses of β-elemene and hematoxylin-eosin staining were injected into the vitreous cavity under the surgical microscope respectively.The pathological changes of rat retina tissues were observed.Retinal slices from each experiment group were collected.Immunohistochemical staining was applied to VEGF,and the expression of VEGF in retinal tissues was detected.ResultsThe results of HE staining showed that the tissue structure of the retina in the NC group showed a clear level.The retina was thinner in DC group than that in the NC group,and the structure was broken.The number of ganglion cells was reduced;the BL group had a slight increase compared with the DC group.The retinal structure in the BH group was better than that in the BL group.After immunohistochemical staining,the retinal results in each experimental group showed that the number of VEGF-positive nuclei in the DC group,NC group,BL group and BH group was　(125.4671±8.4561),(10.1324±2.0334),(75.5123±7.6507),(21.5364±1.7861)respectively,differences between the groups were statistically significant(P＜0.05).Conclusionβ-elemene may become a new target for the treatment of proliferative diabetic retinopathy.At the same time,it can improve the development of advanced DR and delay the further deterioration of retinal tissue.
2018 Vol. 25 (18): 7-09转16 [Abstract] ( 163 ) HTML (41 KB)  PDF  (0 KB)  ( 24 )
10 Experimental study on Qinghuang Powder through inhibition of BCL-2,XIAP-1,c-IAP synergetic induced apoptosis in KG1a cells
WU Jian-wei;HUANG Jian-xu;ZHENG Rong;YE Yong-bin;FAN Jia-xin;LI Yuan-ming;ZENG Yingjian;GUO Kun-yuan
ObjectiveTo study the effects of Qinghuang Powder(composed of two components of Indigo naturalis and Realgar),which the active ingredients are Indirubin and Arsenic Disulfide(As2S2),alone and in combination with cytotoxic effect on non M3 AML KG1a cells,and to investigate the mechanism of cytotoxic effect.MethodsThe cell morphology of KG1a cells acted on with Indirubin and As2S2was observed by Wright Gimsa staining;the rate of cell apoptosis of KG1a cells acted on with Indirubin and As2S2was detected by flow cytometry;CCK-8 detected for apoptosis rate of KG1a cells acted on with Indirubin and As2S2;the expression of Bcl-2,Smac,XIAP-1,c-IAP,Caspase-3 protein of KG1a cells was detected by Western blot.ResultsBoth Indirubin and As2S2had inhibitory effect on proliferation of KG1a cells.Compare with single dose,the combination of Indirubin and As2S2had a higher cell proliferation inhibition rate and apoptosis rate(P＜0.05).When Indirubin and As2S2combined with 1∶1,the combined index was less than 0.9 through CompuSyn,which could also influenced the apoptosis highly,increased the expression of Caspase-3 and Smac protein,and inhibit the expression of BCL-2,XIAP-1 and c-IAP protein.ConclusionThe Indirubin and As2S2,the ingredient of Qinghuang Powder,can inhibit the proliferation of KG1a cells and induce its apoptosis,the mechanism may be related to inhibition of the expression of BCL-2,XIAP-1,c-IAP protein,promote the expression of Caspase-3,Smac protein.Qinghuang powder can be used for the treatment of AML of conventional drug resistance and provides the relevant experimental basis for the treatment of non-M3 type AML.
2018 Vol. 25 (18): 10-16 [Abstract] ( 188 ) HTML (81 KB)  PDF  (0 KB)  ( 138 )
17 Predictive value of CD40 on the sensitivity of neoadjuvant chemotherapy in advanced epithelial ovarian cancer
CHEN Xiao-qing;LIU Yu-ling
ObjectiveTo determine the influence of neoadjuvant chemotherapy(NACT)on the expression of CD40 in ovarian cancer,and further infer whether the CD40 molecule can be used as a biological marker to predict the chemosensitivity of ovarian cancer by examining the expression of CD40 in ovarian cancer tissue.MethodsEighty patients with advanced epithelial ovarian cancer treated in our hospital from December 2015 to December 2017 were selected and they were classified into group A　(n=30)given NACT and group B　(n=50)without NACT according to whether they performed neoadjuvant chemotherapy before surgery or not.The corresponding paraffin sections of ovarian cancer tissues were 30 and 50 respectively.Immunohistochemical method was used to detect the expression of CD40 in two groups of ovarian cancer tissue.ResultsThe total effective rate of chemotherapy in group A　(80.00%)was significantly higher than that of group B　(58.00%),and the difference was statistically significant(P＜0.05).The positive expression rate of CD40 in group A(56.67%)was lower than that of group B(80.00%),and the difference was statistically significant(P＜0.05).The positive expression rate of CD40 in chemo effective patients　(45.83%)was significantly lower than that in chemo ineffective patients(100.00%)of group A,and the difference was statistically significant(P＜0.05).The expression of CD40 in advanced ovarian cancer was positively correlated with Ki-67　(r=0.539,P=0.000).ConclusionThe expression of CD40 was significantly different between NACT and NACT of advanced ovarian cancer.CD40 can be used as a biomarker for predicting the sensitivity of NACT,and it helps to guide the application of NACT in advanced ovarian cancer.
2018 Vol. 25 (18): 17-20 [Abstract] ( 143 ) HTML (47 KB)  PDF  (0 KB)  ( 25 )
21 Monocyte to lymphocyte ratio in patients with glioma and its relationship with isocitrate dehydrogenase 1 mutation
ZHANG Li-zhi;LIU Ping;JI Hui-jun;LI Shou-chun;ZHANG Zhi-wen
ObjectiveTo investigate the potential prognostic significance of monocyte to lymphocyte ratio(MLR)in patients with glioma and its relationship with isocitrate dehydrogenase 1　(IDH1)mutation.MethodsData of 80 patients with glioma who underwent surgery in our hospital from August 2006 to November 2015 were retrospectively analyzed.The receiver operating characteristic curve　(ROC)was used to evaluate the optimal cutoff value of MLR,and based on the optimal cutoff value,which was 0.21,to divide into MLR＜0.21 group(n=37)and MLR≥0.21 group(n=43).The survival time was analyzed by Kaplan-Meier and Log-Rank methods.The Cox′s proportional hazards regression model was used to evaluate the independent prognostic factors,and used the immunohistochemistry method to detect the IDH1 mutation.ResultsMLR was the independent prognostic factors in glioma.The postoperative median overall survival(OS)of patients with MLR＜0.21 group was 57.07 months,and the median OS of patients with MLR≥0.21 group was 48.73 months.The difference of postoperative median OS between the two groups was statistically significant(P＜0.05).The median OS of patients with MLR＜0.21 with IDH1 mutation was significantly longer than that of patients with MLR≥0.21 and IDH1 without mutation,the differences were statistically significant(P＜0.05).ConclusionMLR is simple and convenient,noninvasive,reproducible,and it is a good predictor of prognosis in patients with glioma.
2018 Vol. 25 (18): 21-25 [Abstract] ( 164 ) HTML (41 KB)  PDF  (0 KB)  ( 137 )
26 The correlation between drug resistance of Klebsiella pneumoniae and antibacterial use intensity in patients with hematological diseases
MIAO Wen-juan;LIN Qin-song;ZHANG Ping
ObjectiveTo analyze the correlation between drug resistance of Klebsiella pneumonia and antibacterial use density(AUD)in hospitalized patients with hematological diseases,so as to provide reference for clinical rational use of antibacterial drugs.MethodsA retrospective analysis was used to the drug resistance rate of Klebsiella pneumonia and AUD of frequently-used antibacterial drugs for hospitalized patients from 2013 to 2017 in the Institute of Hematology and Blood Disease Hospital,Chinese Academy of Medical Sciences.The correlation between drug resistance and AUD was analyzed using the Spearman correlation method.ResultsThe drug resistance rates of Klebsiella pneumonia to Cefepime and Meropenem were significantly positively correlated to the AUD of the fourth generation cephalosporins and carbapenem drugs(Cefepime r=0.784,P＜0.01;Meropenem r=0.894,P＜0.01),respectively.No significant correlation could be found between the drug resistance rates of Klebsiella pneumonia to other antimicrobial drugs and AUD of the relevant sorts of bacterial drugs.Meanwhile,the fourth generation cephalosporins,carbapenems,and Tigecyclines were significantly positively correlated with Klebsiella pneumonia resistance to various bacterial drugs.ConclusionThe resistance rates of Klebsiella pneumonia has a certain correlation with AUD of antibacterial drugs.It is recommended that clinical use of the fourth generation cephalosporins,carbapenems,and Tigecycline for the treatment of Klebsiella pneumonia should be particularly careful in order to control and delay the growth of resistant bacteria.
2018 Vol. 25 (18): 26-29转33 [Abstract] ( 179 ) HTML (36 KB)  PDF  (0 KB)  ( 34 )
30 Research progress on pharmacological activities of tetrandrine
GUO Min;ZHANG Ru-yi;CAI Fei
Tetrandrine　(Tet)is extracted from the dry roots of tetrandrine.It belongs to isoquinoline alkaloids.In recent years,Tet is mainly used in clinical diseases,such as cardiovascular diseases,tumors and digestive diseases.Tet has potential value in clinic.This paper reviewes the pharmacological action of tetrandrine,aiming at better research and application of tetrandrine,guiding clinical medication and basic experimental research.
2018 Vol. 25 (18): 30-33 [Abstract] ( 146 ) HTML (45 KB)  PDF  (0 KB)  ( 23 )
34 Analysis on the cause of inital treatment failure of helicobacter pylori
WU Bing-jie;LI Xiao-li
Helicobacter pylori(Hp)infection is a common global infectious disease,in addition to the digestive system diseases such as gastritis,it is also closely related to non digestive such as diabetes,eradication of Hp can play an important role in the prevention and treatment of these diseases.This article reviews the causes of the initial treatment failure of Hp in bacteria,host,treatment program and environment.
2018 Vol. 25 (18): 34-37 [Abstract] ( 164 ) HTML (46 KB)  PDF  (0 KB)  ( 25 )
38 The clinical research of radiofrequency ablation of paroxysmal supraventricular tachycardia with the help of the Carto3 three-dimensional mapping system under low-dose radiation
HUANG Wei-peng;LIN Rui;ZHOU Hao-yue;CHEN Yang-bo;KUANG Hong-sheng
ObjectiveTo discuss the the feasibility,safety and advantages of Carto3 three-dimensional mapping system in guiding radiofrequency ablation for paroxysmal supraventricular tachycardia under low-dose radiation.MethodsA total of 65 patients with paroxysmal supraventricular tachycardia(PSVT)treated in our hospital from February 2015 to November 2017 were selected as the subject,and randomly divided into 2D group　(29 cases)and 3D group　(36 case).The 2D group used conventional X—Ray guide ablation,and the 3D group used Carto3 under low-dose radiation guide ablation.The PSVT type,operation time,X-ray exposure time,X-ray fluoroscopy time and complication rates were compared between the two groups.ResultsAll procedures were actely successful,but one patient in the 2D group was developed transient degreeⅢatrioventricular block during ablation.There was no statistically significant difference in the total operation time between the two groups(P＞0.05).The X-ray exposure time in 3D group was shorter than 2D group,and X-ray fluoroscopy time in 3D group were less than 2D group,the differences were statistically significant(P＜0.05).ConclusionRadiofrequency ablation of paroxysmal supraventricular tachycardia with the help of the Carto3 three-dimensional mapping system under low-dose radiation is safe and feasible，and is helpful to reduce the radiation injury of the doctors and patients.
2018 Vol. 25 (18): 38-41 [Abstract] ( 160 ) HTML (41 KB)  PDF  (0 KB)  ( 23 )
42 Clinical effect of inhaled hormone combined with Tiotropium Bromide in the treatment of asthma chronic obstructive pulmonary overlap syndrome
ZHENG Yan-bing
ObjectiveTo study the clinical effect of asthma and COPD overlap syndrome　（ACOS） of inhaled corticosteroid combined with Tiotropium therapy.MethodsFrom January 2016 to June 2017,100 patients who met the criteria for diagnosis of ACOS were selected.They were divided into two groups according to the different treatment drugs：Sulidide combined with Tiotropium Bromide inhalation group　(experimental group,60 cases)and Sulidide inhalation group(control group,40 cases).The pulmonary function indexes were compared before and after treatment.The scores of asthma symptom,chronic obstructive pulmonary symptom and acute exacerbation were compared between the two groups before and after treatment,and the occurrence of adverse reactions in the two groups was compared.ResultsThere was no significant difference in lung function between the two groups before treatment(P＞0.05).After treatment,the lung function of the two groups was improved,but the lung function index of the experimental group was better than that of the control group after treatment,the differences were statistically significant(P<0.05).ACT,CAT,COPD score and acute exacerbation times showed no significant difference between the two groups before treatment(P＞0.05).ACT,CAT of two groups after treatment were significantly decreased,the frequency of acute exacerbation was significantly reduced,but the experimental group after treatment score and acute exacerbation times were better than the control group,the differences were statistically significant(P<0.05).The incidence of adverse drug reactions in the experimented group was lower than that of the control group,the difference was statistically significant　(P<0.05).ConclusionThe effects of Sulidide inhalation combined with Tiotropium Bromide in ACOS are good,and the prognosis of patients can be improved.
2018 Vol. 25 (18): 42-44转48 [Abstract] ( 139 ) HTML (36 KB)  PDF  (0 KB)  ( 38 )
45 The effect of Runzao Zhiyang Capsules on the treatment of chronic eczema and its influence on the level of EOS and serum IgE in peripheral blood
ZHANG He-cheng;LUO Yu-ping;LIU An-ting
ObjectiveTo investigate the effect of Runzao Zhiyang Capsules in adjuvant treatment of chronic eczema and its effect on serum EOS and serum IgE levels.MethodsA total of 146 cases of chronic eczema patients treated in our hospital from December 2015 to November 2016 were selected.They were divided into observation group and control group according to the random number table method,73 cases in each group.The control group was treated with Epinastine.On the basis of this,the observation group added Runzao Zhiying Capsules to adjuvant therapy.The relevant clinical index data of two groups of patients were observed and recorded.ResultsThe total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Peripheral blood EOS and serum IgE levels in the observation group were lower than the control group for 2 weeks and 4 weeks after treatment,and the differences were statistically significant(P<0.05).Comparison of two groups after treatment in patients with EASI scores and itching rating,the observation group was significantly lower than the control group,the difference was statistically significant(P<0.05).The DLQI scores of the two groups were compared after treatment,and the observation group was significantly lower than the control group,with statistically significant difference(P<0.05).ConclusionThe effects of Runzao Zhiyang Capsules in adjuvant treatment of chronic eczema and its effects on peripheral blood EOS and serum IgE were significant.It can effectively improve the symptoms of patients and improve patient quality of life,and has a certain degree of security.It is worth to promote the clinical application.
2018 Vol. 25 (18): 45-48 [Abstract] ( 183 ) HTML (38 KB)  PDF  (0 KB)  ( 20 )
49 Research on the effect of gastrointestinal reconstruction after gastrectomy in patients with gastric cancer
BAI Shao-hua;ZHU Xiao-ming;CHEN Gan-tao
ObjectiveTo explore the clinical effect of reconstructing digestive tract if different ways after total gastrectomy in patients with gastric cancer.MethodsA total of 100 patients with gastric cancer were selected for this study.All patients were hospitalized from January 2016 to October 2017 and treated with total gastrectomy.After surgery,they were equally divided into observation group and control group by a random number table method.In the observation group,P-shape jejunum pan jejunum esophagus Roux-en-Y anastomosis was used for gastrointestinal reconstruction.In the control group,Moynihan anastomosis for reconstruction of the digestive tract was adopted.The nutritional status and complications of the patients after the two reconstructions were observed.The half-year quality of life in these participants after surgery by the relevant scale was comarped.ResultsThere was no significant difference in the time of gastrointestinal reconstruction between the two groups(P＞0.05).The levels of nutritional indexes such as hemoglobin,albumin,and total protein in the observation group were significantly higher than those in the control group.The average score of quality of life was higher in the observation group than the control group with statistical significance(P<0.05).The incidence of postoperative complications in the observation group was significantly lower than that in the control group with a statistical difference(P<0.05).ConclusionFor patients with gastric cancer after total gastrectomy,the risk of complications by P-shape jejunum pan jejunum esophagus Roux-en-Y anastomosis for gastrointestinal reconstruction is lower,which can effectively improve the nutritional status and quality of life compared with Moynihan anastomosis,so P-shape jejunum pan jejunum esophagus Roux-en-Y anastomosis has a good promotion value.
2018 Vol. 25 (18): 49-51 [Abstract] ( 145 ) HTML (34 KB)  PDF  (0 KB)  ( 30 )
52 The clinical effect of whole-body vertical vibration combined with kinesitherapy in the treatment of Parkinson′s disease
HUANG Shu-min;CHEN Ming-hua
ObjectiveTo approach clinical effect of whole-body vertical vibration combined with kinesitherapy in the treatment of Parkinson′s disease.MethodsThe clinical data of 52 patients with Parkinson′s disease in Rehabilitation Department of the Second People′s Hospital in Zhanjiang City were analyzed,which was to be divided into two group by different treatment method,control group（drug+acupuncture treatment,26 cases)and detection group（kinesitherapy combined with whole-body vertical vibration treatment,26 cases)the UPDRS score and Fugl-Meyer equilibrium function score of two group parkinson patients before treatment and after treatment were detected,the clinical effects,recurrence rate of two group parkinson patients were detected.ResultsThe difference of UPDRS score and Fugl-Meyer equilibrium function score for two group parkinson patients before treatment were no statistical significance　(P＞0.05),the UPDRS score of two group patients after treatment were lower than before treatment,the Fugl-Meyer equilibrium function score were higher than before treatment,the UPDRS score of detection group patients after treatment were lower than control group,the Fugl-Meyer equilibrium function score were higher than control group,the clinical treatment total effective rate of detection group patients was higher than control group,the recurrence rate of detection group patients was lower than control group,the differences were statistical significance　(P<0.05).ConclusionWhole-body vertical vibration combined with kinesitherapy treat Parkinson′s disease,clinical symptoms improve obviously,the clinical effects is good,it is worth to be used.
2018 Vol. 25 (18): 52-54 [Abstract] ( 137 ) HTML (35 KB)  PDF  (0 KB)  ( 33 )
55 Clinical study of sural nerve flap combined with phase-Ⅰlavage in the treatment of traumatic osteomyelitis in the lower segment of tibia
YANG Zhi-fen;YUAN Ya;ZHAN Wei-bing;ZOU Xin-ming;FAN Nai-ren
ObjectiveTo discuss the clinical efficacy of sural nerve flap combined with Phase-Ⅰlavage in treatment of the patients with traumatic osteomyelitis in the lower segment of tibia,so as to provide a basis for improving the treatment effect of osteomyelitis.MethodsAltogether 32 patients with traumatic osteomyelitis in the lower segment of tibia who were treated in the department of orthopedics of our hospital from June 2014 to June 2016 were selected as the subjects of this research.After acquisition of the patients′informed consent,the patients were divided into two groups according to the order of admission,16 cases in each group.The experiment group was treated with combination of sural nerve flap and Phase-Ⅰlavage;while,the control group was treated with traditional surgical treatment methods.Patients′duration of surgery,recovery time and postoperative recurrence of osteomyelitis were compared between two groups.ResultsThe average duration of surgery of the experiment group was shorter than that of the control group,with statistically significant difference(P<0.05);the average postoperative rehabilitation of the experiment group was longer that of the control group,with statistically significant difference(P<0.05).In the control group,3 cases had recurrent osteomyelitis,but the experiment group had no recurrence.The recurrence rate of the experiment group was lower than that of the control group.The two groups had statistically significant difference in the recurrence rate　(P<0.05).ConclusionThe application of combination of sural nerve flap and Phase-Ⅰlavage has a good therapeutic effect in treatment of the patients with traumatic osteomyelitis in the lower segment of tibia,which effectively reduces the possibility of postoperative recurrence of osteomyelitis and is worthy of clinical application.
2018 Vol. 25 (18): 55-57 [Abstract] ( 153 ) HTML (35 KB)  PDF  (0 KB)  ( 27 )
58 Clinical application study of the lateral edge of the rectus abdominis incision combined with three-dimensional digital model for treatment of acetabular fracture following with pelvic fracture
YANG Guo-jun;SHI Yu-fen;CEN Yi-biao;HUANG Hong-yu;LIN Wen-jing;CHEN Jia-kui;SHI Tu-he
ObjectiveTo study the treatment effect of the lateral edge of the rectus abdominis incision combined with three-dimensional digital model for the acetabular fracture following with pelvic fracture patients.MethodsA total of 48 patients with acetabular fracture and pelvic fractures from January 2015 to January 2017 in our hospital were selected into this study.They were divided into the experimental group and the control group according to the chronological order of admission,24 cases in each group.In experimental group,the internal fixation devices for acetabulum and pelvic fracture were reconstruction used the three-dimensional digital technology,and the preoperative virtual surgery simulation were used to guide the actual operation process.In control group,there were no the three-dimensional digital technology and the preoperative virtual surgery simulation.The surgical duration time,intraoperative blood loss,healing time,and hip jointmovement function rating after 6 months were compared.Results①The Surgical completion rate were 100%.②The operation time for experrmental group was shorter than that in the control group　(P＜0.05).③The intraoperative blood loss for experrmental group was more lesser than that in the control group　(P＜0.05).④The fracture healing time for the experimental group was significantly shorter than that in the control group(P＜0.05).⑤For the rate of excellence or good in hip jointmovement function rating after 6 months,the experimental group was significantly higher than the control group,the differences were statistically significant(P＜0.05).ConclusionFor the patients with acetabular fracture and pelvic fractures,the three-dimensional digital reconstruction technology and the preoperative virtual surgery before treatment is conducive to shorten the operation time,reduce the surgical blood loss,shorten fracture healing time,improve the postoperative hip movement function score,and it is worth to further promote in the clinical practice.
2018 Vol. 25 (18): 58-60 [Abstract] ( 161 ) HTML (37 KB)  PDF  (0 KB)  ( 28 )
61 The effect of bonesetting technique and splint external fixation combined with external washing of traditional Chinese medicine in the treatment of Cooney typeⅣdistal radius fracture
WANG Guang-wei;HUO Li-wei;LUO Man;YU Wei-zhong
ObjectiveTo observe the effect of bonesetting technique and splint external fixation combined with external washing of traditional Chinese medicine in the treatment of Cooney typeⅣdistal radius fracture.MethodsFrom January 2015 to June 2017,38 cases CooneyⅣtype of distal radius fracture patients in our hospital were selected and divided into treatment group and control group,accordance with the principle of randomized,19 cases in each group.Treatment group patients was given the repositioning splint external fixation together with Chinese medicine outside treatment,control group patients was given open reduction and plate internal fixation treatment,after treatment for 6 months,according to Cooney criteria to evaluate function of wrist joint and radiographic evaluation standard.ResultsTwo groups of patients with wrist flexion degree,palm imaging measurement in comparison,the difference was statistically significant(P<0.05),the control group was superior to the treatment group,but compared Cooney score difference of two groups of patients,there was no statistically significant difference　(P＞0.05),with Chinese medicine splint external fixation outside wash treatment and surgical treatment CooneyⅣtreatment of distal radius fractures.ConclusionWith Chinese medicine gimmick reset splint external fixation outside wash treatment CooneyⅣcurative effect of distal radius fractures,to CooneyⅣtype of the distal radius fracture treatment provides a new method.
2018 Vol. 25 (18): 61-63转67 [Abstract] ( 179 ) HTML (38 KB)  PDF  (0 KB)  ( 31 )
64 An experimental study of computer navigation and c-arm fluoroscopy for pedicle screw placement in lower cervical spine
WU Deng-jiang;YANG Jin-shun;CHEN Wei-jian
ObjectiveTo compare the accuracy of intraoperative computer navigation and ordinary C-arm fluoroscopy in the placement of lower cervical pedicle screws.MethodsAltogether 16 formalin-soaked adult cervical specimens(C1-T1)that were provided by Teaching and Research Section of Anatomy in our school from June 2013 to June 2016 were selected.The integrity of the posterior and lateral structure was required to be retained.CT scan was used to exclude specimens with osteoporosis and small pedicle screw structure that were unable to perform screw placement.The specimens were randomly divided into two groups,among which a group of specimens were placed in the C2-C7entity under the positive lateral fluoroscopy of the normal C-arm machine;and another group of specimens were inserted into the pedicle screw under the guidance of intraoperative computer navigation.The CT scan and 3D reconstruction of the vertebral pedicle were performed to evaluate the accuracy of the screw placement.ResultsAltogether 96 screws were implanted under the fluoroscopy of C-arm，among which 60(62.5%)were excellent,20(20.8%)were good,16(16.7%)were bad.And 96 screws were implanted by using computer navigation,among which 88(91.7%)were excellent,6(6.2%)were good,2　(2.1%)were bad.The success rate of two kinds of cervical screw insertion methods was compared　(83.3%vs.97.9%),with statistically significant difference(P＜0.05).ConclusionCompared with the conventional C-arm fluoroscopy,the accuracy of screw placement by using computer navigation is obviously improved.
2018 Vol. 25 (18): 64-67 [Abstract] ( 154 ) HTML (38 KB)  PDF  (0 KB)  ( 32 )
68 Effect of closed reduction and intramedullary nail fixation in lateral position and supine position in the treatment of femoral shaft fracture
OU Rong-tong;ZOU Zhong-bing;LIN Wei-peng
objectiveTo compare the effect of closed reduction and intramedullary nail fixation in lateral position and supine position in the treatment of femoral shaft fracture.MethodsA total of 82 cases of femoral shaft fracture treated in our hospital from January 2013 to December 2016 were retrospectively analyzed.According to different positions during the operation,42 patients with supine position were selected as supine position group,40 cases of lateral lying position were used as lateral position group.The operation time,intraoperative blood loss,intraoperative fluoroscopy time,hospitalization time and fracture healing time were observed and compared between the two groups.ResultsThe operation time of the lateral decubitus position was significantly shorter than that in supine position group,the amount of bleeding was significantly lesser than the lateral decubitus position in supine position group,lateral position group postoperative complication was significantly lower than the supine position group,the differences were statistically significant(P<0.05);time of hospitalization and the lateral decubitus position in supine position group and healing time of fracture,the differences were not statistically significant(P＞0.05).1 years of follow-up,compared with two groups of joint function excellent rate,the differences were not statistically significant(P＞0.05).ConclusionIn the surgical treatment of femoral shaft fracture,closed reduction and intramedullary nailing fixation in lateral decubitus is effective and easy to confirm,with small trauma，short operative time and short operative time,which is suitable for clinical application.
2018 Vol. 25 (18): 68-70 [Abstract] ( 140 ) HTML (33 KB)  PDF  (0 KB)  ( 30 )
71 Therapeutic effect of titanium elastic intramedullary nail in treatment of children with extremities fractures
CHEN Jie;LIU Hua
ObjectiveTo analyze the therapeutic effect of titanium elastic intramedullary nail in treatment of children with extremities fracture.MethodsAltogether 100 patients with extremities fracture admitted to our hospital from January 2014 to June 2016 were selected as the objects of this research and randomly divided into two groups,50 cases in each group.The control group was treated with open reduction and plate internal fixation;while,the study group was treated with titanium elastic intramedullary nail(TEN)therapy.The intraoperative and postoperative index,fracture healing,activity of adjacent joints and the incidence of complications were observed in the two groups.Results①The duration of surgery,the amount of intraoperative haemorrhage,the length of incision and the time of hospitalization of the study group were significantly shorter than those of the control group,with statistically significant difference(P<0.05).②The excellent rate fracture treatment of study group was much higher than that of the control group,with statistically significant difference　(P<0.05).③The excellent rate of activity of adjacent joints of the study group was much higher than that of the control group,with statistically significant difference(P<0.05).④The incidence of complications of study group was significantly lower than that of control group,with statistically significant difference(P<0.05).ConclusionThe TEN therapy has a lower incidence of complications,with the features of less trauma and better postoperative recovery.Although there are still some complications,implementation of the corresponding preventive measures can improve the surgical effect significantly,not only reduce the pain of the patients,but also play a positive role in the prognosis,which is worthy of extensive popularization clinically.
2018 Vol. 25 (18): 71-73 [Abstract] ( 148 ) HTML (34 KB)  PDF  (0 KB)  ( 25 )
74 Magnetic resonance imaging in the diagnosis of anterior cruciate ligament rupture in the knee
WANG Yi-ming
ObjectiveTo study the diagnostic value of MRI in the diagnosis of anterior cruciate ligament rupture in the knee.MethodsA random sample of 80 cases of suspected anterior cruciate ligament ruptured from January 2015 to May 2017 in our hospital was compared with the results of arthroscopic examined as the“gold standard” and the results of magnetic resonance imaging were compared.ResultsArthroscopic of 160 patients,70 cases of knee anterior cruciate ligament injury was examined,90 cases of knee anterior cruciate ligament was injured,160 cases of MRI diagnosis 69 cases belong to anterior cruciate ligament of the knee was injured and 91 cases had no anterior cruciate ligament was injured.The sensitivity of MRI diagnosis was 97.14%,specificity was 98.89%,false negative was 2.86%,and false positive was 1.11%.The positive likelihood ratio was(+LR)87.51,the negative likelihood ratio was(-LR)0.029,and the Kappa value was 0.88.There was good agreement between the MRI diagnosis results and the arthroscopic diagnosis of anterior cruciate ligament injury.ConclusionMagnetic resonance imaging technology have non-invasive and easy-to-examine advantages for knee anterior cruciate ligament injury,and have certain clinical value in the diagnosis of anterior cruciate ligament rupture of the knee joint.
2018 Vol. 25 (18): 74-76 [Abstract] ( 149 ) HTML (33 KB)  PDF  (0 KB)  ( 30 )
77 Application effect of high-frequency Doppler ultrasonography in diagnosis of testicular torsion
FENG Jin-jiang;HE Yuan;LIU Xin-yuan
ObjectiveTo analyze the application effect of high-frequency Doppler ultrasound in diagnosis of testicular torsion.MethodsFrom January 2016 to June 2017 in our hospital,102 patients with testicular torsion were recruited.According to the odd-even admission numbers,they were divided into observation group and control group,51 cases in each group.In the observation group,high-frequency Doppler ultrasonography was used,while in the control group,color Doppler ultrasound was adopted.The diagnosis in the two groups was compared.ResultsIn the observation group,the changes of the internal echoes of the testicles,plumpness of the testes,disappearance of blood flow in the testis,normal blood flow in the testes,and reduction of blood flow in the testes were all superior to those in the control group,the differences were statistically significant(P<0.05).There were statistical significance in confirmed diagnostic rate,missed diagnosis rate,and misdiagnosis rate between the two groups,the differences were statistically significant(P<0.05).ConclusionIn the testicular torsion examination,the use of high-frequency Doppler ultrasound diagnosis rate obtains a high diagnostic accordance rate and has important value for clinical promotion.
2018 Vol. 25 (18): 77-79 [Abstract] ( 147 ) HTML (32 KB)  PDF  (0 KB)  ( 26 )
80 Diagnostic value of multi-slice spiral CT in lesions of ileocecal acute abdomen
ZHAO Ming-yi;CHEN Tao
ObjectiveTo explore the diagnostic value of multislice spiral CT(MSCT)for the acute abdominal disease in the ileocecal region in order to guide the rapid diagnosis of this kind of disease.MethodsThe clinical data of 97 patients with suspected ileocecal acute abdomen admitted to our hospital from January 2016 to December 2017 were retrospectively analyzed.All patients were examined by MSCT before operation.Taken surgical results as standard：the value of MSCT in diagnosing acute ileocecal lesions was evaluated.At the same time,the CT manifestations of acute abdomen in different ileocecal parts were analyzed.ResultsAmong the 97 cases of suspected ileocecal acute abdomen,85 cases were diagnosed and 12 cases were excluded：including in 52 cases of appendicitis,20 cases of intussusception and 13 cases of diverticulitis.The sensitivity,specificity,positive predictive value,negative predictive value and coincidence rate of appendicitis,intussusception and diverticulitis were 88.46%,66.67%,95.83%,40.00%,86.21%and 85.00%,66.67%,94.44%,40.00%,82.61%and 92.31%,100.00%,100.00%,75.00%,86.21%.The total coincidence rate of MSCT and surgical diagnosis was 86.60%.The main CT of appendicitis is the obvious thickening of the outer diameter of the appendix,the surrounding inflammatory changes and the permeation of the appendectomy.The perforation of the appendix is perforated by the omentum,forming a lump like structure.The center is low density and thick and uneven.The tumor like changes were seen under the intussusception CT and appeared at the same time with inflammation.The mass of the intussusception was round or ring when the CT scan was vertical.The lump was visible in the lump.The intussusception tube showed obvious“double bowel sign” and “comet tail sign” when CT scanning was not vertical.Diverticulitis CT showed inflammatory infiltration around the diverticulum,showing exudation and thickening of the adipose tissue.In severe cases,diverticulum hemorrhage,perforation and local abscess were seen.ConclusionThe detection rate of acute abdominal disease in appendicitis,diverticulitis and intussusception by MSCT technique is in good agreement with the diagnosis of surgical pathology.It can clearly show the involvement of the lesions and surrounding organs and tissues,and can be used as the first choice for the diagnosis of acute abdominal disease in the ileoceces.
2018 Vol. 25 (18): 80-82 [Abstract] ( 120 ) HTML (35 KB)  PDF  (0 KB)  ( 26 )
83 A double-blind,randomized controlled trial of 1%Bifonazole Cream combined with 40%Urea Ointment in the treatment of onychomycosis
LYU Pei-shan;WANG Jian-song;FANG Yue-li
ObjectiveTo investigate the efficacy of 1%Bifonazole Cream combined with 40%Urea Ointment in the treatment of onychomycosis in a double-blind randomized controlled trial.MethodsIn this study,120 patients diagnosed as onychomycosis in the outpatient department of our hospital from September 2016 to October 2017 were selected as subjects.The patients were divided into comprehensive treatment group and control group by a random number table method,and then directly blinded and sealed in envelop.The envelopes were kept and allocated by those who were not directly involved in the experiment.Both doctors and patients were blinded until the end of the experiment.Unblinding was after the datas were entered and locked.Each group had 60 cases.Patients in the comprehensive treatment group was treated with 1%Bifonazole Cream combined with 40%Urea Ointment in envelops,and in the control group,pariticipants were treated with 1%Bifonazole Cream alone in envelops.The efficacy of the two groups was evaluated according to the efficacy evaluation criteria.The quality of life before and after treatment was evaluated by SF-36 in the two groups.The treatment compliance including following doctor′s advice and treatment was calculated.The potential side effects of nausea,vomiting,dizziness and liver and kidney function damage during the treatment were counted.ResultsThe total effective rate of the comprehensive treatment group was higher than that in the control group,the difference was statistically significant(P＜0.05).The score of treatment compliance in the comprehensive treatment group was higher than that in the control group with a statistical differ-ence(P＜0.05).Before treatment,there was no statistical difference in the scores of SF-36 in the two groups(P＞0.05).After treatment,the SF-36 score of the comprehensive treatment group was significantly higher compared with that in the control group,the difference was statistically significant(P＜0.05).The incidence of adverse reactions in the comprehensive treatment group was not significantly different from that in the control group(P＞0.05).ConclusionThe combination of 1%Bifonazole Cream and 40%Urea Ointment in the treatment of onychomycosis can obtain a definite effect,which can effectively improve the clinical symptoms,enhance patients′treatment compliance,reduce the occurrence of adverse reactions,and promote the amelioration of quality of life.
2018 Vol. 25 (18): 83-86 [Abstract] ( 171 ) HTML (39 KB)  PDF  (0 KB)  ( 29 )
87 Effect of Irbesartan and Hydrochlorothiazidein adjuvant treatment of elderly patients with severe heart failure and its hemodynamic impacts
WANG Rui;HUANG Hua-jie;LIN Jin-jue
ObjectiveTo study the effect of Irbesartan combined with Hydrochlorothiazide and Metoprololin in the treatment of elderly patients with severe heart failure and its hemodynamic impacts.MethodsAltogether 97 cases of elderly patients who were confirmedly diagnosed with severe mental failure and treated in our hospital from December 2015 to January 2017 were selected as subjects and were divided into the study group(n=47)and the control group(n=50)according to the random control method.The control group was given oral Metoprolol Tartrate Tablets,and the study group was given Irbesartan and Hydrochlorothiazide Tablets on the basis of control group.The therapeutic effects of the two groups of patients were compared,the changes of cardiac structure and hemodynamic indexes before and after treatment,and the occurrence of adverse reactions were also compared between the two groups.ResultsThe total effective rate of the study group was significantly higher than that of the control group,the difference was statistically significant(P＜0.05).The left ventricular ejection fraction(LVEF)of the study group was significantly higher than that of the control group,and the LVEF after treatment of the two groups was significantly higher than that before the treatment,the differences were statistically significant(P＜0.05).After treatment,the systemic vascular resistance(SVR),pulmonary artery wedge pressure(PAWP),pulmonary artery mean pressure(PAMP)and right atrial pressure(RAP)of two groups were significantly lower than those before treatment,the post-treatment cardiac output(CO)and cardiac index　(CI)were significantly higher than those before treatment,the differences were statistically significant(P＜0.05).After treatment,the PAWP,PAMP and SVR of the study group were significantly lower than those of the control group,the CO was higher than that in the control group,the differences were statistically significant　(P＜0.05),but there was no statistically significant difference between the two groups in RAP and CI(P＞0.05).The total incidence of adverse drug reactions between the two groups was compared,and the difference was not statistically significant(P＞0.05).ConclusionThe application of combination of Irbesartanand and Hydrochlorothiazide demonstrates its better effectiveness in the adjuvant treatment of elderly patients with severe mental failure and improve patients′hemodynamics more obviously in contrast with single application of Metoprolol.
2018 Vol. 25 (18): 87-90 [Abstract] ( 143 ) HTML (42 KB)  PDF  (0 KB)  ( 34 )
91 Medication situation of several antitumor oral chinese patent medicines in our hospital from 2015 to 2017
WANG Xiao-ping;ZHENG Xiao-qing;LIN Yu-hui;YU Xiao-yan
ObjectiveTo investigate the medication situation of antitumor oral Chinese patent medicines in our hospital from 2015 to 2017.MethodsMicrosoft Excel software was selected to analyze and count the amount,type,percentage of drug costs,daily average cost(DDC),and frequency of drug use(DDDs)of anticancer oral Chinese patent medicines from 2015 to 2017 in our hospital.ResultsIn 2015,the proportion of the total amount of anti-tumor Chinese patent medicines accounted for 1.45%of the total amount of drugs,the proportion in 2016 was 1.24%,and the proportion in 2017 was 1.17%.The top four in terms of the amount of drugs used for a single variety were Aiyu Capsules,Diyu Shengbai Tablets,Weixuening Granules and Kanglaite Capsules.The top four antitumor oral Chinese medicines of DDDs were Aiyu Capsules,Diyu Shengbai Tablets,Weixuening Capsules and Kanglaite Capsules,and the top four antitumor oral Chinese medicines for the DDC of drugs were Aiyu Capsules,Diyu Shengbai Tablets,Weixuening Capsules and Kanglaite Capsules.ConclusionThe use of antitumor oral Chinese patent medicine in our hospital is basically reasonable,the amount of performance is increasing year by year,in the actual clinical use of drugs should strengthen management and supervision,and then to effectively evade the risk of medication.
2018 Vol. 25 (18): 91-93 [Abstract] ( 130 ) HTML (34 KB)  PDF  (0 KB)  ( 32 )
94 Effect comparison of Rosuvastatin Calcium and Simvastatin in the treatment of hyperlipidemia complicated with hypertension
ZHANG Yuan-sheng;GONG De-xiang;WU Hui-jing
ObjectiveTo compare the efficacy of Rosuvastatin Calcium or Simvastatin in patients with hyperlipidemia and hypertension.MethodsA total of 200 patients with hyperlipidemia complicated with hypertension treated in our hospital from May 1,2016 to May 1,2017 were selected as subjects.They were equally divided into two groups based on the random number table method,100 cases in each group.The control group was treated with Simvastatin and the observation group was treated Rosuvastatin Calcium.The indexe of blood lipidsare was described in the following aspects of total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),and blood pressure indexes included systolic and diastolic blood pressures were compared between the two groups.ResultsAfter treatment,the TC,TG and LDL-C in the observation group were　(4.16±0.36)mmol/L,(1.61±0.28)mmol/L and　(2.27±0.41)mmol/L,which were all lower than those of the control group of(5.75±0.51)mmol/L,(2.41±0.29)mmol/L and(3.26±0.38)mmol/L,while the HDL-C in the observation group was(1.52±0.31)mmol/L,which was higher than that in the control group of(1.25±0.34)mmol/L with significance differences　(P＜0.05).The systolic blood pressure and diastolic blood pressure were　(120.62±8.48)mmHg and　(80.46±4.26)mmHg in the observation group,which were lower than those in the control group of(138.29±12.05)mmHg and(89.62±5.18)mmHg,with statistical significance differences(P＜0.05).ConclusionFor patients with hyperlipidemia and hypertension,Resuvastatin Calcium therapy is more effective than Simvastatin.
2018 Vol. 25 (18): 94-96 [Abstract] ( 143 ) HTML (34 KB)  PDF  (0 KB)  ( 35 )
97 Clinical effect of Atorvastatin in the treatment of acute respiratory distress syndrome
ZHANG Sheng-rong;HU Xing-zhou;JIN Hui-chun;XU Su-ping;CHEN Xiao-li
ObjectiveTo explore the clinical efficacy of Atorvastatin in the treatment of acute respiratory distress syndrome(ARDS).MethodsAltogether 50 patients with ARDS who were treated in intensive care unit(ICU)of our hospital from January 2015 to December 2016 were selected as subjects and randomly divided into the control group(n=25)and the observation group　(n=25)according to the random number table method.The control group was given mechanical ventilation to adjust the positive pressure of the terminal respiration and the oxygen concentration,the control group was also given etiological treatment of primary diseases and anti-infective treatment based on reasonable application.On the basis of the control group,the observation group was fed with Atorvastatin Tablets by the nose at night,40 mg per day,and was treated for 28 days.The levels of C-reactive protein,complement C3,complement C4,CD4+/CD8+,cholesterol,triacylglycerol,low-density lipoprotein and high-density lipoprotein were compared and observed.And the time of mechanical ventilation,stay in intensive care unit(ICU)and length of stay in hospital were compared between two groups.ResultsAfter treatment,the C-reactive protein level of the observation group was lower than that of the control group　(P＜0.05).No statistically significant difference was seen between two groups in the complement C3,C4 and CD4+/CD8+(P＞0.05).The cholesterol,triacylglycerol,low-density lipoprotein and high-density lipoprotein of the observation group were lower than those of the control group,with statistically significant difference　(P＜0.05).After treatment,the time of mechanical ventilation,stay in intensive care unit(ICU)and length of stay in hospital of the observation group were all shorter than those of the control group,with statistically significant difference　(P＜0.05).ConclusionAtorvastatin can reduce the inflammatory reaction of ARDS patients and improve patients′immunity and prognosis,which has certain clinical application value.
2018 Vol. 25 (18): 97-99 [Abstract] ( 121 ) HTML (38 KB)  PDF  (0 KB)  ( 30 )
100 Effect of Compound Glycyrrhizin Capsules combined with Piyan Decoction treating facial corticosteroid-dependent dermatitis
LIN Xin-min;WEN Yu-li
ObjectiveTo study the clinical effect of Compound Glycyrrhizin Capsules combined with Piyan Decoction treating facial corticosteroid-dependent dermatitis.MethodsA total of 70 patients with facial glucocorticoid-dependent dermatitis treated in our hospital from March 2014 to March 2017 were enrolled.By a random number method,they were divided into the research group(n=35)and control group(n=35).In the research group,Compound Glycyrrhizin Capsules combined with Piyan Decoction was used,while in the control group,Compound Glycyrrhizin Capsules alone was applied.The clinical symptom scores and quality of life scores were calculated before and after treatment,and the clinical effect between the two groups was compared.ResultsThe total effectiveness rate of the research group was 91.43%,which was higher than that of the control group(80.00%)(P＜0.05).There was no significant difference in symptom score or quality of life score between the two groups before treatment(P＞0.05).After treatment,the above-mentioned score in the two groups were significantly improved before treatment(P＜0.05),and the symptom score in the research group was lower than that in the control group,and the quality of life score was higher than that in the control group　(P＜0.05).The incidence of adverse reactions in the research group was 11.43%,and 17.14%in the control group,and there was no significant difference between the two groups(P＞0.05).The recurrence rate of the research group was 8.57%,which was lower than that in the control group　(22.86%),and there was a statistical difference(P＜0.05).ConclusionThe effect of Compound Glycyrrhizin Capsules combined with Piyan Decoction treating facial corticosteroid-dependent dermatitis is better,and it can effectively relieves clinical symptoms,promotes rapid recovery of the disease,has high safety,avoids adverse reactions,protects patients′physical and mental health,and provide the guarantee for the prognosis.
2018 Vol. 25 (18): 100-102 [Abstract] ( 139 ) HTML (34 KB)  PDF  (0 KB)  ( 27 )
103 Thefeasibility　analysisofWenyanghuoxuePrescription　ofChinese medicine auxiliarily treating chronic heart failure
HUANG Zhang-yu;ZENG Guo-han
ObjectiveTo observe the clinical effect of Wenyanghuoxue Prescription of Chinese medicine auxiliarily treating chronic heart failure,and to explore its rationality and applicability.MethodsFifty patients with heart failure patients treated in our hospital from February 2015 and December 2017 were selected and the patients were divided into the control group(n=25)and treatment group(n=25).The control group was treated with traditional western medicine,and the treatment group was treated with self-made Wenyanghuoxue Prescription based on the control group.The treatment effect of the two groups was observed.ResultsThe total effective rate of the treatment group was significantly higher than that of the control group　(P＜0.05).The value of left ventricular ejection fraction　(LEVF)in the two groups was higher than that before treatment(P＜0.05),and the value of LEVF in the treatment group was higher than that of the control group,the difference was statistically significant(P＜0.01).The level of brain natriuretic peptide　(BNP)after treatment in the two groups was lower than that before treatment(P＜0.05),and the level of BNP in the treatment group was lower than that of the control group　(P＜0.01).ConclusionThe effect of Wenyanghuoxue Prescription of Chinese medicine auxiliarily treating chronic heart failure is good,and it can obviously improve the LEVF,BNP of patients.For the patients with heart failure,the treatment of Wenyangyiqi based on western medicine is more obvious and worth promoting.
2018 Vol. 25 (18): 103-105 [Abstract] ( 126 ) HTML (36 KB)  PDF  (0 KB)  ( 25 )
106 Differential diagnosis effect of alpha fetoprotein and abnormal prothrombin on hepatocellular carcinoma
XUE Sha;XUE Ting
ObjectiveTo explore the differential diagnosis effect of serum alpha fetoprotein(AFP)and abnormal prothrombin(DCP)on hepatocellular carcinoma in liver tumor patients.MethodsA total of 301 patients with hepatic tumor treated in the Yuncheng Central Hospital from October 2014 to September 2016 were selected as the subject,and divided into hepatocellular carcinoma group(207 cases)and non-hepatocellular carcinoma group(94 cases).The concentrations of AFP and DCP were detected in these patients.The histopathological examination results by puncturing was considered as the final diagnostic criteria to evaluate the differential diagnostic values of two serum markers on liver tumors.ResultsThe AFP level in the hepatocellular carcinoma group was significantly higher than that in the non-hepatocellular carcinoma groups.The abnormal prothrombin level was much higher than that of the non-hepatocellular carcinoma,the difference was statistically significant(P＜0.05).The combination of AFP and DCP can rise the diagnostic specificity up to 97.6%.There were 156 cases in double positivity,44 cases in double negative,10 cases in AFP(+)DCP(-),and 101 cases in AFP(-)DCP(+).The sensitivity was 78.74%,and specificity accounted for 81.91%.ConclusionAbnormal prothrombin(DCP)is similar to serum AFP in the differential diagnosis of hepatocellular carcinoma.Combined detection is beneficial to increasing the diagnostic sensitivity and reducing missed diagnosis.
2018 Vol. 25 (18): 106-108 [Abstract] ( 150 ) HTML (34 KB)  PDF  (0 KB)  ( 24 )
109 Expression and significance of plasma water pathway protein 5 and vascular endothelial growth factor in neonatal acute respiratory distress syndrome
XIE Rui-yu;LI Wei-chun;YANG Xu;ZHANG Ke-chang
ObjectiveTo observe the expression and changes of plasma water pathway protein 5　(AQP5)and vascular endothelial growth factor(VEGF)in neonatal acute respiratory distress syndrome(ARDS).MethodsFrom October 2015 to May 2017,37 plasma samples of newborns with ARDS admitted to our hospital were selected and 20 samples of nonrespiratory diseases were collected at the same time.AQP 5 and VEGF concentrations were determined by enzymelinked immunosorbent assay　(ELISA)and statistically analyzed.ResultsSerum AQP 5 levels in ARDS group were significantly higher than those in non-respiratory diseases group,and the differences were statistically significant(P＜0.05).The level of AQP 5 in ARDS group at 72 h after adission was significantly higher than that in admission and 24 h after admission,and the difference was statistically significant(P＜0.05).There was no significant difference in serum AQP 5 levels among children with non-respiratory diseases for three time periods(P＞0.05).VEGF levels in ARDS group were significantly higher than those in non-respiratory diseases group,and the differences were statistically significant(P＜0.05).The VEGF level in ARDS group at 24 h after adission was significantly higher than that in admission and 72 h after admission,and it tended to decline after 72 h,the difference was statistically significant(P＜0.05).Plasma VEGF level of children with non-respiratory diseases was higher than that of children in 24,72 h after admission,and decreased gradually with the extension of birth time,with statistical significance(P＜0.05).ConclusionAQP5 and vascular endothelial growth factor are highly expressed in neonatal acute respiratory distress syndrome.They may be involved in the occurrence and development of neonatal respiratory distress syndrome.
2018 Vol. 25 (18): 109-111 [Abstract] ( 106 ) HTML (36 KB)  PDF  (0 KB)  ( 28 )
112 The diagnostic significance analysis of soluble b7-h4 in rheumatoid arthritis
YAO Jiong-tao
ObjectiveTo study the significance of soluble B7-H4 in the diagnosis of rheumatoid arthritis.MethodsA total of 65 rheumatoid arthritis(RA)patients and 66 osteoarthritis(OA)patients admitted to our hospital from January 2013 to December 2014 were selected.At the same time,70 patients were selected for physical examination in our hospital.The serum levels of sB7-H4,anti-cyclic citrullinated peptide(CCP)antibodies,and glucose 6-phosphate isomerase(GPI)levels were measured in three groups by enzyme-linked immunosorbent assay　(ELISA).The patient′s rheumatoid factor(RF)was measured by immunoturbidimetry.The significance of sB7-H4 in the diagnosis of RA was compared and analyzed.ResultsThe levels of sB7-H4,RF,anti-CCP antibody and GPI in RA group were significantly higher than those in OA group and healthy group,the differences were statistically significant(P<0.05).sB7-H4 was positively correlated with RF and anti-CCP antibodies but not with GPI levels.In addition,the positive rates of sB7-H4,RF,anti-CCP antibodies,and GPI in the RA group were significantly higher than those in the OA group and the healthy group,the differences were statistically significant(P<0.05).ConclusionsB7-H4 has high value in diagnosing RA and has good clinical application prospects.
2018 Vol. 25 (18): 112-114 [Abstract] ( 107 ) HTML (33 KB)  PDF  (0 KB)  ( 40 )
115 Application values of combined use of hemoglobin A2 and fetal hemoglobin in the screening of β-thalassemia in children
CHANG Jian-feng;LUO Yu-ting;CHEN Li
ObjectiveTo investigate the value of combined detection of hemoglobin A2　(HbA2)and fetal hemoglobin(HbF)in the screening of β -thalassemia in children.MethodsA total of 48 children with β -thalassemia admitted in our hospital from January 2015 to October 2017 were selected as the experimental group and 50 healthy children undergoing physical examination in our hospital as the reference group.The levels of HbA2 and HbF in the two groups were observed and compared.The gene test results were taken as the gold standard and used the ROC curve to compare HbA2,HbF and the area under the curve(AUC),cutoff value,sensitivity and specificity,and used the Logistic regression to analysis HbA2 and HbF in children with β-thalassemia diagnostic value.Results.The levels of HbA2 and HbF in the experimental group were　(5.12±0.65)%and　(1.27±0.86)%,which were significantly higher than those in the reference group　(2.63±0.76)%and　(0.49±0.38)%,respectively　(P<0.05).The AUC of HbA2,HbF and their combination were 0.923,0.896 and 0.954,respectively and the cutoff values of them were 3.5%and 0.6%respectively.The diagnostic sensitivity and specificity of HbA2 and HbF joint diagnosis were 97.92%and 86.00%respectively.Logistic regression analysis showed that both HbA2 and HbF were statistically significant in diagnosing β-thalassemia children　(P<0.05),and the diagnostic value of HbA2 was significantly higher than that of HbF.ConclusionDetection of HbA2 and HbF in children with β-thalassemia screening has a certain value,and the diagnostic value of HbA2 was significantly better than HbF,a combination of the two can greatly improve the diagnostic accuracy.
2018 Vol. 25 (18): 115-117 [Abstract] ( 130 ) HTML (35 KB)  PDF  (0 KB)  ( 31 )
118 Significance of detection of serum cystatin C and beta 2-microglobulin in early diagnosis of diabetic nephropathy
ZENG Peng-fly;ZHANG Yu-sheng;ZHENG Rui
ObjectiveTo explore the significance of combined detection of Cys-C and β2-microglobulin in the early diagnosis of diabetic nephropathy.MethodsA total of 90 patients with diabetic nephropathy treated in our hospital from September 2015 to August 2017 were selected as the observation group,90 healthy physical examination personnel were selected as the reference group in the same time period,and the observation group was divided into stageⅠ,stageⅡ,stage Ⅲand Ⅳaccording to the difference of the time.The levels of β2-microglobulin and Cys-C in each group were detected by latex enhanced immunoturbidimetry and circulating enzyme method,and the results of each group were compared.ResultsThe level of β2-microglobulin and Cys-C in the observation group was higher than that in the reference group,and the differences were statistically significant(P<0.05).The level of β2-microglobulin and Cys-C in patients with stageⅡtoⅣdiabetic nephropathy were higher than those in stageⅠdiabetic nephropathy,with statistical significance(P<0.05),the levels of β2-microglobulin and Cys-C level combined detection rate were higher than the single test,the differences were statistically significant　(P<0.05).ConclusionDuring the early diagnosis of diabetic nephropathy,Cys-C+β2-microglobulin can be detected reasonably.By analyzing the level of β2-microglobulin and Cys-C level,the early diagnosis of the disease and the smooth treatment of late stage can be fully guaranteed.
2018 Vol. 25 (18): 118-120 [Abstract] ( 148 ) HTML (40 KB)  PDF  (0 KB)  ( 134 )
121 Change on the plasma D-dimer and four coagulation indices in high-risk parturient women
WEI Lin-yan;HUANG Qiu-yan
ObjectiveTo observe the change of four coagulation indices and plasma D-Dimer（DD）in high-risk parturient women.Methods120 parturients admitted to our hospital from June 1st,2016 to August 31st,2016 were selected as research objects.According to different parturients,they were divided into observation group　(high-risk parturients)and control group(normal parturients),there were 60 cases in each group,and the changes of D-D and blood coagulation of two kinds of parturients were compared.ResultsThe serum thromboplastin time　(APTT)of patients in the observation group was significantly lower than that of the control group,and the the D-D,prothrombin time　(PT),prothrombin time(TT)and fibrinogen(FIB)in the observation group were significantly higher than those in the control group,the difference was statistically significant(P＜0.05).ConclusionFor high parturient women,the fibrinolysis and coagulation function are changed in resulting the increasing DD,FIB and TT and decreasing PT and APTT.Although the postpartum hemorrhage is partially relieved,the complications are exacerbated.The close and dynamic monitoring can avoid the severe complications.
2018 Vol. 25 (18): 121-123 [Abstract] ( 130 ) HTML (33 KB)  PDF  (0 KB)  ( 33 )
124 Application effect analysis of performance appraisal in shared nursing unit
XIE Jin-xia;YANG Rui-hong;LI Cai-zhen;ZENG Li-mei;TAO La-zhi
ObjectiveTo study the application effect of performance appraisal in the shared nursing unit.MethodsAccording to the problems and features in managing nurses,the corresponding assessment criteria and content were formulated.In our hospital from January 2016 to January 2017,the performance appraisal system for nurse managers at all levels were implemented,and the score was conducted for implementation and quality of nursing system at all levels,and the patients′satisfaction degree with the nursing work was evaluated.ResultsAfter the implementation,the basic nursing rate,the written qualification rate of nursing documents,the qualified rate of nursing staff assessment,and the achievement rate of nursing plans were all higher than before implementation with statistical significance after comparison(P＜0.05).There was no significant difference in health education knowledge,intact rate of first aid items,or qualified rate of special medicine management before and after implementation　(P＞0.05).After implementation,the score for the implementation of nursing rules and regulations was(99.10±0.96)points,and the score for nursing quality management and continuous improvement was　(99.37±1.07)points,which were significantly higher than those before implementation,which were displayed statistical significance(P＜0.05).After the implementation,the total satisfaction degree of the nursing subjects was 97.27%,which was much higher than before implementation with a significant difference　(P＜0.05).ConclusionPerformance appraisal management system in the shared nursing unit is scientific and concise,and can improve the work efficiency of nursing staff and the satisfaction degree on management,also can improve patients′satisfaction degree with the nursing work.
2018 Vol. 25 (18): 124-126转143 [Abstract] ( 121 ) HTML (37 KB)  PDF  (0 KB)  ( 25 )
127 Comparison of cleaning and disinfection effects of different pipeline cleaning and disinfection methods for electro-stomach irrigator
HU Li-hong;LIAO Nan-bo
ObjectiveTo investigate the cleaning and disinfection effects of different methods of cleaning and disinfecting different tubes in electro-stomach irrigator.MethodsFrom January 2015 to December 2016,3 electric lavage machines used in our hospital were washed for 150 times,which were evenly divided into clean water group,detergent group,and multi-enzyme group in random,50 times in each group.After being cleaned and disinfected,they were observed visually and sample-inspected after biological monitoring at days 1,3,and 5 after storage in order to compare the cleaning and disinfection effects of the three cleaning methods.ResultsThe qualified rate in the multi-enzyme group was 98.00%,significantly higher than 86.00%in the detergent group and 68.00%in the clean water group with statistical significance　(P＜0.05).Day 1 after cleaning and disinfection,the proportion of bacteria≤20 CFU/cm2in the three groups were compared,the differences were not statistically significant(P＞0.05).Day 3 and 5 after cleaning and disinfection,the proportion of bacteria≤20 CFU/cm2in the multi-enzyme group was much higher than that in the detergent group and clean water group　(P＜0.05).ConclusionFor electro-stomach irrigator pipelines,application of multi-enzyme diluent for cleaning and disinfecting is effective,and easy to operate,which can effectively prevent and control cross-infection and iatrogenic infection.
2018 Vol. 25 (18): 127-129 [Abstract] ( 145 ) HTML (36 KB)  PDF  (0 KB)  ( 34 )
130 Performance evaluation of Sysmex CS2000i Automatic Coagulation Analyzer
CHEN Zhen-xing;MO Jun;YANG Yue-xing;DU Feng-yun;WANG Shao-ling
ObjectiveTo comprehensively evaluate the performance of Sysmex CS2000i Automatic Coagulation Analyzer.MethodsFrom June to December in 2016,20 healthy persons and clinical patients in our hospital were selected as the subjects of this study.The accuracy,precision,trueness,comparability,carryover rate and linear analysis of Sysmex CS2000i were evaluated and the detection efficiency were compared between the CS2000i and CS5100.ResultsThe accuracy of normal and abnormal level of the three indexes of fibrinogen　(Fib),activated partial thromboplastin time(APTT)and prothrombin time　(PT)detected by CS2000i were both within the range of deviation requirements.And the accuracy met the standard.The batch inprecision results at normal and abnormal levels of the three indexes of PT,APTT and Fib detected by CS2000i were met the range of deviation requirements.The results of day unprecision of the normal level and the abnormal level of the three indexes of PT,APTT and Fib detected by CS2000i were all met the deviation range.The results of the carrying pollution rate of the three indexes of PT,APTT and Fib detected by CS2000i were all met the requirements.The actual mean value of Fib detected by CS2000i was positively correlated with the theoretical value,the correlation formula was y=0.9261x+0.2001　(R2=0.9914).It met the requirements and had a good linear range.The biological reference interval of the three indexes of PT,APTT and Fib detected by CS2000i were in accordance with the recommendation interval.There was no significant difference in the detection values of the three indexes of PT,APTT and Fib between CS2000i and CS5100　(P＞0.05),and the deviation values all met the requirements.The results of interlaboratory quality assessment of the three indexes of PT,APTT and Fib detected by CS2000i were consistent with the quality assessment of the national coagulation laboratory,and all of them passed.ConclusionCS2000i has good detection performance and can be widely used and diagnosed in clinic.
2018 Vol. 25 (18): 130-133 [Abstract] ( 138 ) HTML (46 KB)  PDF  (0 KB)  ( 143 )
134 An analysis of clinical receiving a patient for treatment condition in 217 vagrants with dysphrenia
HONG Er-lang;CHANG Feng-kun
ObjectiveTo analyze the clinical receiving a patient for treatment condition in 217 vagrants with dysphrenia.MethodsThe clinical data about 217 vagrants with dysphrenia treated from June 1 to August 31,2017 in our hospital was analyzed.The general data,diagnosis classifications,disease classification and final treatment outcomes were observed.ResultsFor 217 patients,the rate of schizophrenia was highest(45.16%,98 cases),followed by psychotic disorder(39.17%,85 cases).There were 138 complicated cases(63.59%),including 15 cases of infectious diseases(10.87%),22 cases of soft tissue injury(15.94%),45 cases of moderate anemia(32.61%),12 cases of hypertension(8.70%),32 cases of electrocardiographic abnormality(23.19%),8 cases of diabetes mellitus(5.80%),3 cases of fibroid(2.17%)and one pregnant case(0.72%).There were 122 cases of returning back to family life(56.22%),91 cases of receiving the social assistance　(41.94%)and 4 cases of transferring to another hospital(1.84%)and the rate of returning back to family life(56.22%)was significantly higher than that of social assistance(41.94%),transferring rate(1.84%)(P＜0.05).ConclusionThe vagrants with dysphrenia have their special social,mental and physiological characteristics and it is necessary to actively take the treatment and family and social assistance.It is worthy of clinical selection.
2018 Vol. 25 (18): 134-136 [Abstract] ( 128 ) HTML (34 KB)  PDF  (0 KB)  ( 27 )
137 Improvement of digestive endoscope disinfection method and its effect observation
ZHANG Ting;LUO Zu-mei;LIU Hai-yan;ZHANG Guo-an;GAN Mei-chan;HUANG Miao-ying
ObjectiveTo investigate the effect of improved cleaning and disinfection methods.MethodsA total of 210 digestive endoscopes that were routinely cleaned and disinfected from May 2016 to October 2017 in our hospital were selected as the control group,210 digestive endoscopes with improved cleaning and disinfection methods were selected as the observation group.The qualified rate of endoscopic disinfection between the two groups was compared.ResultsThere was no significant difference between the two groups in the effect of endoscopic disinfection for one minute　(P＞0.05).The effect of disinfection in the observation group for three minutes and five minutes was better than that in the control group respectively and the differences were statistically significant(P＜0.05).The qualified rate of the lens body and the bending part of the observation group were higher than those of the control group(P＜0.05).There was no statistical difference in the passing rate of the biopsy hole between the two groups　(P＞0.05).There was no significant difference in patients between the two groups for the incidence of gastrointestinal discomfort or chemical colitis after microscopic examination　(P＞0.05).The incidence of adverse reactions caused by o-phthalaldehyde in the observation group was lower than that of the control group(glutaraldehyde),and the difference was statistically significant(P＜0.05).ConclusionAfter the disinfection method of digestive endoscope is improved,the use of o-phthalaldehyde for disinfection has a significant effect,and it can greatly improve the qualified rate of cleaning and disinfecting the endoscope,effectively avoid the secondary pollution of endoscope,and the iatrogenicity caused by digestive endoscopy.Infection has a good preventive effect and it has a good preventive effect on iatrogenic infection caused by digestive endoscopy.
2018 Vol. 25 (18): 137-139转157 [Abstract] ( 108 ) HTML (38 KB)  PDF  (0 KB)  ( 28 )
140 Application of local anatomy to experimental teaching of choking agent poisoning
CHEN Ming-liang
ObjectiveTo explore the role of local anatomy in experimental teaching of chocking agent poisoning and to evaluate the teaching effect.MethodsThe five-year undergraduate students,grade 2016,in the Army Medical University were enrolled and divided into the experimental group and the control group by a simple randomized grouping method,30 cases in each group.The control group conducted experimental teaching of choking agent poisoning according to the traditional experimental teaching method without reviewing the related anatomy knowledge of lung before doing experiments.The experimental group reviewed the related anatomy knowledge of lung as well as training the operational skills before doing experiments.At the end of the experiment class,the experimental operation time,the experimental report results(score),and the students′satisfaction of the experimental teaching were analyzed.ResultsThe average experimental operation time of the experimental group　([22.00±3.00]min)was shorter than that of the control group　([36.00±2.00]min),the difference was statistically significant(P<0.05).The average scores of the experimental group　([79.53±1.62]points)was higher than that of the control group　([91.25±2.32]points),the difference was statistically significant(P<0.05).The scores of students′satisfaction in the experimental group([91.00±0.10]points)was higher than that of the experimental teaching group([80.00±0.20]points),the difference was statistically significant(P<0.05).ConclusionIt is emphasized that the introduction of local anatomy knowledge could improve the teaching quality of experimental teaching of chocking agent poisoning,which should be popularized and applied in other related experimental teaching of chemical agent prevention.
2018 Vol. 25 (18): 140-143 [Abstract] ( 120 ) HTML (40 KB)  PDF  (0 KB)  ( 30 )
144 The Experience of Clinicopathological Probation for Vocational Medical Students
WANG Min;LI Jun-tao;LIU Qi-li;LEI Wei-hua
Despite clinicopathology′s vital role in the diagnosis,treatment and prognosis of diseases,clinical medical students in vocational colleges are generally lack of such kind of knowledge.To make up for vocational medical students′insufficiency in knowledge of clinicopathology,Zhaoqing Medical College has conducted clinical probation during winter vacations for vocational medical students.Through making adequate preparations,employing the“clinic-pathology-clinic”probation model,making summaries and exchanging their learning experience,the students have fully understood the importance of clinicopathology and been able to apply their knowledge of clinicopathology to some clinical problems.
2018 Vol. 25 (18): 144-146 [Abstract] ( 119 ) HTML (36 KB)  PDF  (0 KB)  ( 29 )
147 Impact analysis of core clinical competency training on workplace violence for emergency nurses
ZHONG Yu-yu;YUAN Xiu-ying;LIU Huan-zhang;LU Cui-bei
ObjectiveTo analyze the influence of core clinical competency training on workplace violence for emergency nurses.MethodsAltogether 66,067 patients who were treated in Department of Emergency from January to December in 2015 by nurses taking no core clinical competence training were selected as the control group.While,57,335 patients treated in Department of Emergency from June 2016 to June 2017 by nurses who already took core clinical competence training were selected as the experiment group.The clinical results were analyzed.ResultsThe total incidence of injury events in the workplace of emergency nurses of experiment group was 0.070%,lower than that of the control group　(0.470%),and the difference was statistically significant(P＜0.05).The proportion of abusive events,harassment events,disturbing work order events,limb injury events and carrying weapon threat events of experiment group was 0.040%,0.010%,0.010%,0.001%and 0.000%,lower than those of control group　(0.280%,0.070%,0.050%,0.020%and 0.020%),and the differences were statistically significant(P＜0.05).ConclusionCore clinical competency training has a significant impact on the workplace violence for emergency nurses.
2018 Vol. 25 (18): 147-149 [Abstract] ( 134 ) HTML (31 KB)  PDF  (0 KB)  ( 29 )
150 Study on diversified teaching mode in ICU resident standardized training in Department of Neurosurgical Intensive Care Unit
XU Dan;SUN Xiao-chuan;PENG Yan
ObjectiveTo explore the function of diversified teaching model,which are problem-based learning,situational simulation teaching and case-based learning in standardized training for residents in Department of Neurosurgical Intensive Care Unit(NICU).MethodsA total of 45 residents in the Department of NICU from 2016 to 2017 were taught in the experimental group,and the diversified teaching mode was carried out.As the control group,the traditional teaching mode was carried out in 36 residents from 2014 to 2015.The teaching effect was analyzed through examination results and questionnaire survey.ResultsThe examination results of the experimental group(theoretical examination,physical examination,diagnosis and treatment operation,service quality and total scores)were significantly higher than those of the control group,and the differences were statistically significant(P＜0.05).The scores of the questionnaire in the experimental group were also higher than those in the control group,and the difference was statistically significant(P＜0.05).ConclusionThe application of diversified teaching mode in the standardized training of residents in NICU can significantly improve the teaching effect.
2018 Vol. 25 (18): 150-152 [Abstract] ( 123 ) HTML (35 KB)  PDF  (0 KB)  ( 35 )
153 Analysis of diagnosis and treatment of hypertensive cerebral hemorrhage caused by primary aldosteronism in three cases
DAI Pei;SONG Gui-qin
Primary aldosteronism refers to a syndrome that the adrenocortical lesions lead to increased aldosterone auto-secretion and renin-angiotensin system inhibition,together with hypertension with or without hypokalemia mainly characterized by plasma high aldosterone levels and low renin levels.It is a leading cause for secondary hypertension.The syndrome can be screened by using plasma aldosterone/renin ratio(ARR),adrenal ultrasound,adrenal computed tomography(CT)and enhanced,adrenal magnetic resonance imaging(MRI).The key treatment is actively control of blood pressure and actively potassium supplementation to correct electrolyte imbalances.For aldosteronoma patients,the preferred therapy is total unilateral adrenalectomy or tumor resection under laparoscope.This paper analyzed and summarized the diagnosis and treatment of three patients with hypertensive cerebral hemorrhage caused by primary aldosteronism in order to intensify awareness of the disease,enhance the clinical experience,and guide the clinical diagnosis and treatment.
2018 Vol. 25 (18): 153-157 [Abstract] ( 108 ) HTML (44 KB)  PDF  (0 KB)  ( 35 )
158 A case analysis of visual blur caused by Voriconazole in the treatment of patients with Invasive pulmonary aspergillus infection
LIU Yun

In this article,one patient with Invasive pulmonary aspergillus infection treated by Voriconazole in department of respiratory medicine of our hospital was selected and the reason of visual blur caused by Voriconazole was analyzed on the basis of excluding all kinds of mental disorders and metabolic encephalopathy before voriconazole treatment.To this type of patients,Volcicconazole can be continued to be selected when other drugs against Invasive pulmonary aspergillus infection can not effectively control the patients′condition,but it is necessary to adjust the dosage of drugs and monitor closely when the drug was used to ensure the rationality and safety of the clinical medication.
2018 Vol. 25 (18): 158-160 [Abstract] ( 139 ) HTML (34 KB)  PDF  (0 KB)  ( 29 )
161 Influence of nursing intervention on patients with schizophrenia undergoing low frequency transcranial magnetic stimulation
LIU Jia;ZENG Miao-rong;WEN Xiu-hong;ZHU Yan-ling
ObjectiveTo investigate the influence of nursing intervention on patients with schizophrenia treated with low frequency transcranial magnetic stimulation　（rTMS）.MethodsA total of 96 schizophrenic patients treated with RTMS in our hospital from August 2016 to August 2017 were selected as the research object.They were divided into reference group and experimental group by random number table method,with 48 cases in each group.The reference group received routine nursing,while the experimental group received targeted nursing intervention based on it.The treatment completion status,positive and negative symptom scores before and after treatment and quality of life scores of the two groups were compared.ResultsA total of 40 cases(83.3%)in the experimental group completed all the treatments and 6 cases(12.5%)completed 11 to 19 treatments.In the reference group,31 cases(64.6%)completed all the treatments and 10 cases(20.8%)completed 11 to 19 treatments.The proportion of the treatment completed in the experimental group was significantly higher than that in the reference group,and the difference was statistically significant（χ2=8.853,P＜0.05）.Before the intervention,there was no significant difference in PANSS scores and quality of life scores between the two groups(P>0.05).After the intervention,PANSS scores and quality of life scores of the two groups of patients were improved.The scores of positive and negative symptom scales in the experimental group were significantly lower than those in the reference group,while the quality of life scores were significantly higher than those in the reference group,the difference was statistically significant(P<0.05).ConclusionThe patients with schizophrenia received targeted nursing intervention during the treatment of low frequency transcranial magnetic stimulation,which can obviously improve the completion of the treatment and the improvement of the mental symptoms of the patients,thus improving the therapeutic effect and the quality of life of the patients.It is worth popularizing and applying in clinic.
2018 Vol. 25 (18): 161- [Abstract] ( 125 ) HTML (36 KB)  PDF  (0 KB)  ( 25 )
164 Application effect of mobile propaganda and education platform in hemodialysis patients performed with surgeries
LIU Lan-xia;ZHANG Jian-rong;CHEN Zhi-jin;LI Gui-hong;LI Gui-lan
ObjectiveTo explore the application effect of mobile propaganda and education platform in hemodialysis patients performed with surgeries.MethodsA total of 107 dialysis patients admitted to our hospital from January 2016 to December 2017 who underwent surgery were selected.Using objective sampling method,53 patients admitted from January to December 2016 were set as control group and 54 patients admitted from January to December 2017 were set as observation group.The observation group adopted a mobile,convenient and visual education model built by hemodialysis specialist nurses based on wechat platform during the perioperative period,while the control group adopted a faceto-face health education model for routine surgical nurses during the perioperative period.The preoperative awareness of the prevention of surgical site infection,postoperative wound healing,and the incidence of surgical site infection in the two groups were compared.ResultsThe observation group was better than the control group in the cognition of prevention of surgical site infection before operation and the healing of incision after operation,and the difference was statistically significant(P＜0.05).The incidence of surgical site infection in the observation was lower than that of the control group,and the difference was statistically significant(P＜0.05).ConclusionThe mobile propaganda and education platform under the guidance of professional nurses in the hemodialysis room can provide convenient and effective guidance for hemodialysis patients undergoing surgeries.It can improve patients′knowledge of infection prevention in surgical sites and reduce the incidence of surgical site infection.
2018 Vol. 25 (18): 164-1699 [Abstract] ( 126 ) HTML (37 KB)  PDF  (0 KB)  ( 28 )
167 Application observation of WeChat platform health education in patients undergoing minimally invasive surgery kidney stone
LI Ming
ObjectiveTo approach application effect of WeChat platform health education in patients undergoing minimally invasive surgery kidney stone.MethodsSixty patients with renal calculus undergoing minimally invasive surgery admitted to our hospital from February 2015 to February 2017 were selected and divided into control group(conventional nursing method)and observation group(wechat platform health education)according to different education methods,with 30 patients in each group.The score of patients′knowledge of kidney stones and the score of patients′cognition of minimally invasive surgery in the two groups were observed,and the nursing satisfaction and treatment compliance in the two groups were compared.ResultsThe scores of patients in the observation group on the degree of mastery of knowledge about kidney stones and the degree of cognition of minimally invasive surgery were higher than those in the control group,and the difference was statistically significant(P＜0.05).The nursing satisfaction and treatment compliance of patients in the observation group were higher than those in the control group,and the difference was statistically significant(P＜0.05).ConclusionThe application of kidney stone minimally invasive surgery patients by WeChat platform health education,which can improve kidney stone knowledge mastery degree and minimally invasive surgical cognition,increase nursing satisfaction and treatment compliance,and it is worthy of clinical promotion and application.
2018 Vol. 25 (18): 167-169 [Abstract] ( 117 ) HTML (34 KB)  PDF  (0 KB)  ( 19 )
170 Effect of U shaped pillow in application of the downward posture in the rear of retinal detachment
FENG Xiao-xia
ObjectiveTo study the effects and nursing experience of U shaped pillow in application of the downward posture in the rear of retinal detachment.MethodsFifty patients who underwent retinal detachment surgery in our hospital from June 1st,2015 to June 30th,2017 were selected as research objects,and were divided into reference group and study group by random number table method,with 25 cases in each group.In the reference group,patients were given routine downward posture nursing instead of Ushaped pillow,while in the research group,patients were given Ushaped pillow for downward posture nursing.The intervention effects of the two groups were observed and compared,and the nursing experience was summarized.ResultsThe duration of body position maintenance and first sleep in the study group were significantly longer than those in the reference group,the length of stay in the study group was shorter than that in the reference group,and the difference was statistically significant(P＜0.05).The incidence of discomfort symptoms in the study group was significantly lower than that in the reference group,and the difference was statistically significant(P＜0.05).ConclusionThe U shaped pillow in application of the downward posture in the rear of retinal detachment can effectively prolong patients′posture maintenance time,improve sleep condition,shorten hospitalization time,reduce the incidence of uncomfortable symptoms and relieve patients′pain,thus it is worth promoting.
2018 Vol. 25 (18): 170-172 [Abstract] ( 118 ) HTML (34 KB)  PDF  (0 KB)  ( 22 )
173 Effect of graded management strategy on hypertension patients in community
HUANG Shu-qin;MA Hou-rong;HAN Yun
ObjectiveTo observe the effect of grading management strategy in community hypertensive patients.MethodsA total of 120 patients with hypertension from January to December 2014 in our hospital′s jurisdiction community were selected as the research objects,and were divided into regular group and graded group by random number table method,with 60 cases in each group.The routine group implemented the routine management strategy,while the graded group implemented the grading management strategy.The blood pressure control and quality of life of the two groups of patients were compared.ResultsThere was no significant difference in blood pressure level between the two groups before management（P＞0.05）.The blood pressure level of the two groups was lower than that of the control group，and that of the grading group was lower than that of the routine group,the difference was statistically significant （P＜0.05）.The effective rate of blood pressure control in the graded group was higher than that in the conventional group，and the difference was statistically significant （P＜0.05）.There was no significant difference in QOL scores between the two groups before management （P＞0.05）.The QOL scores of the two groups after the management were higher than those before the management,and the grading group was higher than that of the routine group,the difference was statistically significant（P＜0.05）.ConclusionThe classification management strategy is effective in the implementation of hypertension patients in community.It can obviously improve the effect of blood pressure control and the quality of life.It is worthy of recommendation and application.
2018 Vol. 25 (18): 173-175 [Abstract] ( 124 ) HTML (36 KB)  PDF  (0 KB)  ( 29 )
176 Effect study of path-based health education on improving negative emotions in hypertensive patients
ZHOU Min-jian
ObjectiveTo explore and study the effect of path-based health education on improving the negative emotions in hypertensive patients and make an analysis and comparison.MethodsA total of 142 patients with hypertension admitted to our hospital from August 2014 to December 2017 were selected as research objects,and divided into study group and control group according to the method of visiting months,with 71 cases in each group.The control group was treated with routine therapy and routine health education,while the study group was treated with routine therapy and routine health education combined with path-based health education.CESD,SDS,SAS score,disease knowledge mastery and nursing satisfaction were compared between the two groups.ResultsBefore the intervention,there was no significant difference in CESD scores between the two groups　(P>0.05).CESD scores of patients in two groups after intervention were lower than those before intervention,and CESD scores of patients in study group after intervention were lower than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in SDS and SAS scores between the two groups before intervention　(P>0.05).The scores of SDS and SAS in the two groups after intervention were lower than those before intervention,and the scores of SDS and SAS in the study group were lower than those in the control group after intervention,the differences were statistically significant(P<0.05).The mastery overall rate of disease knowledge in the study group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).The nursing overall satisfaction of patients in the study group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).ConclusionPath-based health education for hypertensive patients can significantly improve their negative emotions,and increase their mastery of disease knowledge as well as nursing satisfaction.
2018 Vol. 25 (18): 176-178 [Abstract] ( 138 ) HTML (38 KB)  PDF  (0 KB)  ( 31 )
179 Influence of evidence-based nursing mode on operation indexes of surgical patients in family planning department
XIAO Min
ObjectiveTo explore the influence of evidence-based nursing mode on the operation indexes and emotion of patients in family planning surgical,and to provide the basis for clinical application.MethodsFrom January 2016 to December 2017,1000 patients with family planning surgery in our hospital were selected and divided into control group and experimental group by random number table method,with 500 patients in each group.The evidence-based nursing model and the conventional nursing model were used respectively.The operation indexes,depression and anxiety changes and the satisfaction of the two groups of patients with the nursing model were analyzed.ResultsThe time of getting out of bed,exhausting gas and hospitalization in the experimental group were shorter than those in the control group,the difference was statistically significant(P<0.05).Before surgery,there was no significant difference in SAS and SDS scores between the two groups(P>0.05).One month after surgery,the SAS and SDS scores of the control group were not statistically different from those before surgery(P>0.05).The SAS and SDS scores of the patients in the experimental group were lower than those before the operation,and the SAS and SDS scores of the patients in the experimental group were lower than those of the control group,the differences were statistically significant(P<0.05).The total satisfaction rate of patients in the experimental group was higher than that in the control group,the difference was statistically significant(P<0.05).ConclusionThe evidence-based nursing mode could accelerate the recovery speed of the patients and accelerate the postoperative bed time and exhaust time and also can improve the anxiety and nervousness of family planning patients.
2018 Vol. 25 (18): 179-181转185 [Abstract] ( 127 ) HTML (37 KB)  PDF  (0 KB)  ( 25 )
182 Analysis of the application of optimized nursing procedures in laparoscopic gastrointestinal surgery
GAO Qiu-jia;CAO Xiu-hong
ObjectiveTo explore the clinical effects of optimized nursing procedures before and after laparoscopic surgery in patients with gastrointestinal diseases.MethodsFrom January 2017 to March 2018,84 patients with gastrointestinal diseases in our hospital underwent laparoscopic surgery were selected.The patients were divided into control group and observation group according to the admission time,42 patients in each group.The control group was given perioperative nursing,while the observation group was combined to optimize the nursing process.The perioperative observation indexes of the two groups were compared,and the nursing quality,nursing satisfaction,postoperative complication rate and negative emotion improvement of the two groups were compared.In addition,the two groups of patients with operation and nursing equipment preparation were compared and analyzed.ResultsThe operation time and hospitalization time in the observation group were significantly shorter than those in the control group and the difference was statistically significant(P＜0.05);and the intraoperative blood loss was significantly less than that in the control group,and the difference was statistically significant(P＜0.05).The scores of nursing quality and satisfaction of patients in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P＜0.05);and the scores of negative emotions were significantly lower than those in the control group　(P＜0.05),the difference was statistically significant(P＜0.05).The incidence of postoperative complications in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P＜0.05);the rate of good operation and the rate of preparation of surgical instruments for nursing staff in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P＜0.05).ConclusionThe nursing effect of optimized nursing procedure performed during the laparoscopic surgery of patients with gastrointestinal diseases is significantly better than that of routine nursing care,indicating that the optimized nursing procedure has a higher promotion value in the nursing care of such patients.
2018 Vol. 25 (18): 182-185 [Abstract] ( 109 ) HTML (36 KB)  PDF  (0 KB)  ( 28 )
186 Influence of personalized information support on breastfeeding success rate and self-efficacy of primipara
DUAN Chun-fang;DENG Lan-zhen
ObjectiveTo explore the application value of personalized information support in primiparas,and to observe its effect on breastfeeding success rate and self-efficacy.MethodsEighty primipara who gave birth in our hospital from January to December 2017 were selected in the study.They were divided into control group and observation group by random number table method,with 40 cases in each group.Patients in the control group were given routine nursing,while patients in the observation group were given personalized information support.The scores of self-rating depression scale　(SDS),breast-feeding knowledge,self-efficacy scale　(GSES)and adaptability were compared between the two groups before and after the intervention,and the success rate of breast-feeding between the two groups before and after the intervention.ResultsBefore the intervention,there was no significant difference in GSES score and adaptability score between the two groups　(P＞0.05).After the intervention,the scores of GSES and adaptability in the two groups were higher than those before the intervention,and the scores of GSES and adaptability in the observation group were higher than those in the control group after the intervention,the difference was statistically significant(P＜0.05).Before the intervention,there was no significant difference between the two groups in SDS score and breast feeding knowledge score(P＞0.05).After the intervention,the SDS scores of the two groups of patients were lower than those before the intervention and the scores of breast feeding knowledge were higher than those before the intervention.Moreover,the SDS scores of the patients in the observation group were lower than those in the control group,and the scores of breast feeding knowledge were higher than those in the control group,and the difference was statistically significant(P＜0.05).After the intervention,the success rate of breast-feeding in the observation group was 90.00%　(36/40),which was higher than 67.50%　(29/40)in the control group，and the difference was statistically significant(χ2=4.021,P<0.05).ConclusionPersonalized information support can effectively improve negative emotions,which improve breastfeeding success rate and self-efficacy,and is worthy of promotion.
2018 Vol. 25 (18): 186-188转191 [Abstract] ( 119 ) HTML (36 KB)  PDF  (0 KB)  ( 34 )
189 The application of group nursing management mode in operating room nursing management
WU Min
ObjectiveTo explore the application effect of group nursing management mode in operating room nursing management.MethodsTwenty-six nurses in the operating room of our hospital were selected as the control group from June 2015 to June 2016,and the routine nursing management mode was implemented in nursing management.Twentyfour nurses in the operating room of our hospital were selected as the research group from July 2016 to July 2017,and the group nursing management mode was implemented in nursing management.After 3 months of implementation,the nursing quality of two groups was compared.Fifty operations were randomly selected during the implementation of nursing management mode in two groups,and the satisfaction of 50 surgeons and 50 patients was investigated.ResultsThe nursing quality score of patients in the study group was significantly higher than that of the control group(P＜0.05).The satisfaction degree of surgeons in the study group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The patients′satisfaction in the study group was higher than that in the control group,and the difference was statistically significant(P＜0.05).ConclusionIn the nursing management of operating room,the effect of implementing group nursing management mode is more ideal,which can improve the nursing quality and improve the satisfaction of surgeons and patients,and it is worthy of in-depth study and promotion.
2018 Vol. 25 (18): 189-191 [Abstract] ( 103 ) HTML (32 KB)  PDF  (0 KB)  ( 31 )
192 Application effect of high-quality nursing on elderly patients with painless myocardial ischemia
KONG Xiao-mei;GONG Xiao-xue
ObjectiveTo investigate the effect of high quality nursing intervention in elderly patients with painless myocardial ischemia.MethodsA total of 94 elderly patients with painless myocardial ischemia admitted to our hospital from May 2016 to May 2017 were selected as research objects,and randomly divided into control group and study group,47 cases in each group.The control group was given traditional routine nursing intervention,while the study group was given high-quality nursing intervention,and the nursing effect,complication rate and nursing satisfaction of the two groups were compared and analyzed.ResultsThe sleep quality score of patients in the study group was lower than that of the control group,the incidence of diseases was less than that of the control group,and the incidence of diseases was shorter than that of the control group.The nursing effect of patients in the study group was superior to that of the control group,the differences were statistically significant difference　(P＜0.05).The incidence of complications in the study group was significantly lower than that in the control group　(P＜0.05).The nursing overall satisfaction of patients in study group was higher than that of control group,and the difference was statistically significant(P＜0.05).ConclusionThe application of high-quality nursing intervention in elderly patients with painless myocardial ischemia can improve the performance of patients with symptoms,control the incidence of complications,the nursing program can meet the patient care requirements,higher satisfaction with clinical care,the value of the application prominent.
2018 Vol. 25 (18): 192-194 [Abstract] ( 124 ) HTML (35 KB)  PDF  (0 KB)  ( 28 )
195 Application effect observation of risk management in patients with skin defect and skin flap repair
CHEN Miao-fen
ObjectiveTo analyze the clinical value of risk management in patients with skin defect and skin flap repair.MethodsFrom November 2015 to November 2017,70 patients with skin defect and skin flap were selected and divided into control group and observation group according to the order of admission,35 cases in each group.Routine nursing was used in the control group.The observation group was given risk management.The ADL quality of life score,hospitalization time,incidence of adverse events and total effective rate were compared between the two groups.ResultsThe scores of ADL quality of life in the observation group were higher than before nursing,and the difference was statistically significant(P＜0.05).The ADL quality of life score of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).The hospital stay in the observation group was shorter than that in the control group,and the difference was statistically significant(P＜0.05).The incidence of adverse events in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).ConclusionThe risk management can improve their life quality,shorten the hospitalization time,reduce the adverse event rate and increase the clinical effective rate.It is worth to be widely applied in clinical practice.
2018 Vol. 25 (18): 195-封三 [Abstract] ( 116 ) HTML (34 KB)  PDF  (0 KB)  ( 31 )
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