单核细胞与淋巴细胞比值对神经胶质瘤临床预后及异柠檬酸脱氢酶基因1突变的影响

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Abstract ObjectiveTo investigate the potential prognostic significance of monocyte to lymphocyte ratio(MLR)in patients with glioma and its relationship with isocitrate dehydrogenase 1　(IDH1)mutation.MethodsData of 80 patients with glioma who underwent surgery in our hospital from August 2006 to November 2015 were retrospectively analyzed.The receiver operating characteristic curve　(ROC)was used to evaluate the optimal cutoff value of MLR,and based on the optimal cutoff value,which was 0.21,to divide into MLR＜0.21 group(n=37)and MLR≥0.21 group(n=43).The survival time was analyzed by Kaplan-Meier and Log-Rank methods.The Cox′s proportional hazards regression model was used to evaluate the independent prognostic factors,and used the immunohistochemistry method to detect the IDH1 mutation.ResultsMLR was the independent prognostic factors in glioma.The postoperative median overall survival(OS)of patients with MLR＜0.21 group was 57.07 months,and the median OS of patients with MLR≥0.21 group was 48.73 months.The difference of postoperative median OS between the two groups was statistically significant(P＜0.05).The median OS of patients with MLR＜0.21 with IDH1 mutation was significantly longer than that of patients with MLR≥0.21 and IDH1 without mutation,the differences were statistically significant(P＜0.05).ConclusionMLR is simple and convenient,noninvasive,reproducible,and it is a good predictor of prognosis in patients with glioma.

Key words： Monocyte to lymphocyte ratio Glioma Isocitrate dehydrogenase 1 Prognosis Overall survival

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	Articles by authors
	ZHANG Li-zhi
	LIU Ping
	JI Hui-jun
	LI Shou-chun
	ZHANG Zhi-wen

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ZHANG Li-zhi,LIU Ping,JI Hui-jun, et al. Monocyte to lymphocyte ratio in patients with glioma and its relationship with isocitrate dehydrogenase 1 mutation[J]. 中国当代医药, 2018, 25(18): 21-25.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I18/21

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