厄贝沙坦氢氯噻嗪辅助治疗老年重症心力衰竭的效果及对血流动力学的影响

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Abstract ObjectiveTo study the effect of Irbesartan combined with Hydrochlorothiazide and Metoprololin in the treatment of elderly patients with severe heart failure and its hemodynamic impacts.MethodsAltogether 97 cases of elderly patients who were confirmedly diagnosed with severe mental failure and treated in our hospital from December 2015 to January 2017 were selected as subjects and were divided into the study group(n=47)and the control group(n=50)according to the random control method.The control group was given oral Metoprolol Tartrate Tablets,and the study group was given Irbesartan and Hydrochlorothiazide Tablets on the basis of control group.The therapeutic effects of the two groups of patients were compared,the changes of cardiac structure and hemodynamic indexes before and after treatment,and the occurrence of adverse reactions were also compared between the two groups.ResultsThe total effective rate of the study group was significantly higher than that of the control group,the difference was statistically significant(P＜0.05).The left ventricular ejection fraction(LVEF)of the study group was significantly higher than that of the control group,and the LVEF after treatment of the two groups was significantly higher than that before the treatment,the differences were statistically significant(P＜0.05).After treatment,the systemic vascular resistance(SVR),pulmonary artery wedge pressure(PAWP),pulmonary artery mean pressure(PAMP)and right atrial pressure(RAP)of two groups were significantly lower than those before treatment,the post-treatment cardiac output(CO)and cardiac index　(CI)were significantly higher than those before treatment,the differences were statistically significant(P＜0.05).After treatment,the PAWP,PAMP and SVR of the study group were significantly lower than those of the control group,the CO was higher than that in the control group,the differences were statistically significant　(P＜0.05),but there was no statistically significant difference between the two groups in RAP and CI(P＞0.05).The total incidence of adverse drug reactions between the two groups was compared,and the difference was not statistically significant(P＞0.05).ConclusionThe application of combination of Irbesartanand and Hydrochlorothiazide demonstrates its better effectiveness in the adjuvant treatment of elderly patients with severe mental failure and improve patients′hemodynamics more obviously in contrast with single application of Metoprolol.

Key words： Irbesartan Hydrochlorothiazide Heart failure Hemodynamics Adjuvant therapy

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	WANG Rui
	HUANG Hua-jie
	LIN Jin-jue

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WANG Rui,HUANG Hua-jie,LIN Jin-jue. Effect of Irbesartan and Hydrochlorothiazidein adjuvant treatment of elderly patients with severe heart failure and its hemodynamic impacts[J]. 中国当代医药, 2018, 25(18): 87-90.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I18/87

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