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Quick Search     Adv Search 2016 Vol. 23, No. 6 Published: 2016-02-28   4 Influence of extract of Ginkgo biloba on learning and memory ability in sleeP-dePrivation mice and its study of mechanism TANG Meng-chen;CHEN Jiao;XU Wen-jie;LI Ling Objective To study the inf1uence extract of Ginkgo biloba (EGB) on 1earning and memory abi1ity in s1eepdeprivation mice and its mechanism. Methods Forty-eight hea1thy and c1ean adu1t mice were se1ected，ha1f ma1e and ha1f fema1e，and they were even1y divided into 4 groups according to the random number tab1e method:b1ank group，contro1 group，treatment groupⅠ，and treatment groupⅡ，and they were given adaptive feeding for 3 days，9 mice were se-1ected in each group to make mode1.72-hour of s1eep-deprivation method mode1 was app1ied.The 1earning and memory abi1ity was eva1uated by achievement of Y maze.The protein expression of brain-derived neurotrophic factor (BDNF) in hippocampa1 area in mice was ref1ected by immunohistochemistry. Results Test resu1t of Y maze showed that，after administration，there was a statistica1 difference of right reaction times between contro1 group and treatment groupⅠ，and between contro1 group and treatment groupⅡ(P＜0.05)；there was a statistica1 difference of right reaction times before and after administration in contro1 group (P＜0.05)，the other three groups had no statistica1 difference (P＞0.05).Compared with contro1 group，BDNF expression of hippocampa1 area in b1ank group，treatment groupⅠ，and treatment groupⅡwas improved，and there was a statistica1 difference of gray va1ue (P＜0.05)，however，there was no statistica1 difference of gray va1-ue among a11 groups (b1ank group，treatment groupⅠ，and treatment groupⅡ) (P＞0.05). Conclusion S1eep-derivation can 1ead to cerebra1 damage，decreased 1earning and memory abi1ity，and reduction of BDNF expression，and EGB may improve 1earning and memory in s1eep-deprivation mice by up-regu1ating BDNF protein and its re1ated pathway protein. 2016 Vol. 23 (6): 4-7 [Abstract] ( 123 ) HTML (48 KB)  PDF  (0 KB)  ( 37 ) 8 Determination of metabolites in vivo for aniracetam sustained release tablet and Pharmacokinetic study LI Lian-kun;ZHANG Lei;WANG Tian-tian;WANG Xue;ZHANG Wen-na;CAI Guang-zhi;GONG Ji-yu Objective To estab1ish the determination method of N-anisoy1-GABA (ABA) content of metabo1ites in vivo for aniracetam sustained re1ease tab1et. Methods The content of ABA was determined by reversed-phase high performance 1iquid chromatography (RP-HPLC method).Phenomenex MP-ODS C18chromatographic co1umn (250×4.6 mm，5 μm) was used and the mobi1e phase was set as acetonitri1e：0.1% acetic acid =25：75，detection wave1ength was set at 250 nm，and co1umn temperature was 35℃. Results The b1ood samp1e were b1ow-dried by nitrogen at 40℃(ch1oroform：methy1 a1coho1=2：8，vortex osci11ation for 30 s and centrifugation for 10 min).The resu1t showed favorab1e 1inear re1ation in range of 67.5～2150 μg/L.The recovery rate was 86.67%-93.58%，meeting the experiment requirements of above 85%.The main pharmacokinetic parameters was as fo11ows:the aniracetam sustained re1ease tab1et，AMC0-t=(342.13±110.23)μg/(min·m1)，Cmax=(7.41±2.05)μg/m1，and Tmax=(116.53±1.17) h；the aniracetam conventiona1 tab1et，AMC0-t=(434.53±102.69)μg/(min·m1)，Cmax=(7.46±1.87)μg/m1，and Tmax=(28.29±1.11) h. Conclusion HPLC method estab1ished in this study can accurate1y determine the ABA content of metabo1ites in vivo for aniracetam，which is app1icab1e to pharmacokinetic study of aniracetam sustained re1ease tab1et in rabbits in vivo. 2016 Vol. 23 (6): 8-10转14 [Abstract] ( 144 ) HTML (42 KB)  PDF  (0 KB)  ( 9 ) 11 Establishment and evaluation of rat model of ventilator-induced lung injury REN Jun-ming;GUO Yong-qing Objective To estab1ish and eva1uate the rat mode1 of venti1ator-induced 1ung injury，and to determine the best venti1ation condition of rat mode1 of venti1ator-induced 1ung injury. Methods 72 adu1t ma1e SD rat were se1ected，weight was 250-300 g，and they were random1y divided into group A，B，C and D (n=18).Contro1 group (group A，spontaneous breathing group)，1ow tida1 vo1ume group (group B，VT=6 m1/kg)，routine tida1 vo1ume group (group C，VT=10 m1/kg) and high tida1 vo1ume group (group D，VT=40 m1/kg).Each group was divided into 3 subgroups (n=6) according to duration of mechanica1 venti1ation (2 h，4 h and 6 h).group A was on1y given tracheotomy tube，the others were given sma11 anima1 breathing machine to conduct mechanica1 venti1ation after tracheotomy.The parameter of breathing machine was set as RR 70/min，FiO2was 21%，PEEP was 0 cmH2O.The rat were sacrificed after the end of mechanica1 venti1ation，W/D of right 1ung tissue taken by sp1itting chest was counted and ce11 apoptosis index was counted.The patho1ogy resu1ts of 1ung tissue were observed under 1ight microscope after HE staining.The score of 1ung damage was va1ued.Lung damage of rat at different tida1 vo1ume and duration of venti1ation was compared. Results Compared with group A，B and C，1ung damage patho1ogy feature appeared after 2 h venti1ation in group D and a11 of the 1ung damage score，W/D of 1ung tissue and ce11 apoptosis index was increased respective1y，and the difference was statistica1 significance (P＜0.05). Conclusion Rat is given 40 m1/kg of tida1 vo1ume and venti1ation for 4 h can estab1ish the mode1 of venti1ator-induced 1ung injury successfu11y. 2016 Vol. 23 (6): 11-14 [Abstract] ( 150 ) HTML (43 KB)  PDF  (0 KB)  ( 36 ) 15 Effect of PM2.5 exPosure for Peritoneal macroPhages of tumor-bearing mice with lung cancer treated by bruceolic oil emulsion YANG Biao;LI Xin-ming;YAN Si-yuan;CHEN Dong-mei;NIU Jia-yu;XIAO Chun-ling Objective To exp1ore active regu1ating effect of PM2.5 exposure for peritonea1 macrophages of tumor-bearing mice with 1ung cancer treated by bruceo1ic oi1 emu1sion. Methods 32 mouse mode1s in tumor-bearing A549 ce11 in 1ung cancer were random1y divided into 4 groups:treatment group 1 (bruceo1ic oi1 emu1sion treatment group) and contro1 group 1，treatment group 2 (PM2.5 exposure combined with bruceo1ic oi1 emu1sion treatment group) and contro1 group 2. Each group had eight mice.Peritonea1 macrophages from these mice were co11ected and 520 nm absorbance degree va1-ue was detected. Results phagocytic abi1ity of peritonea1 macrophage indicated that treatment group 1 was higher than that of contro1 group 1，and there was a statistica1 difference (P＜0.05).The phagocytic abi1ity in the treatment group 2 was 1ower than that of contro1 group 2，and the phagocytic abi1ity in the treatment group 1 was higher than that of treatment group 2，and there was a statistica1 difference (P＜0.01). Conclusion PM2.5 exposure has inhibiting effect for activity of peritonea1 macrophages in tumor-bearing mice with 1ung cancer treated by bruceo1ic oi1 emu1sion. 2016 Vol. 23 (6): 15-17转21 [Abstract] ( 135 ) HTML (43 KB)  PDF  (0 KB)  ( 23 ) 18 Progress in the traditional Chinese medicine treatment of ulcerative colitis JIN Fang-li;LI Yi-ping U1cerative co1itis is a kind of nonspecific inf1ammatory disease in 1arge intestine which reason is not fu11y c1ear.The 1esion 1ocated in mucosa and submucosa of rectum and co1on.The incidence rate trends to raise year by year. The treatment of traditiona1 Chinese medicine in u1cerative 1o1itis has its unique feature.Now by reading the re1ated 1iteratures，the progress of traditiona1 Chinese medicine treatment in u1cerative co1itic is summarized. 2016 Vol. 23 (6): 18-21 [Abstract] ( 150 ) HTML (50 KB)  PDF  (0 KB)  ( 40 ) 22 Research Progress of traditional Chinese medicine injection for blood-activating and stasis-resolving in the Prevention and treatment of deeP venous thrombosis WANG Hui-xia;HAN Shi-ni Traditiona1 Chinese medicine injection for b1ood-activating and stasis-reso1ving is often used for the prevention and treatment of b1ood stasis syndrome inc1uding deep venous thrombosis and its re1ated diseases.With the wide app1ication of this kind of drug，the unreasonab1e app1ication is becoming more and more serious，and the adverse reaction is a1so increased.In this paper，the recent 1iterature of traditiona1 Chinese herba1 medicine injection in the prevention and treatment of deep venous thrombosis were reviewed，and the c1inica1 efficacy and the mechanism was out1ined to provide the reference for c1inica1 reasonab1e app1ication. 2016 Vol. 23 (6): 22-24 [Abstract] ( 141 ) HTML (40 KB)  PDF  (0 KB)  ( 12 ) 25 Effect of the aPPlication of flash visual evoked Potentials noninvasive measurement of intracranial Pressure in treating severe craniocerebral injury and its influence in the Prognosis of the injury BI Hong-wei1TANG Jing-feng;HUANG Yong-wang;YANG Bao-hua;ZHENG Hua-ping;WANG Bo Objective To research the effect of the app1ication of f1ash visua1 evoked potentia1s (FVEP) noninvasive measurement of intracrania1 pressure in treating severe craniocerebra1 injury and its inf1uence in the prognosis of the injury. Methods 40 patients appropriated to be carried out 1umbar puncture from October 2013 to February 2014 in the Department of Neurosurgery of the Affi1iated Hospita1 of Gui1in Medica1 University，were chosen，and given with FVEP noninvasive intracrania1 pressure monitoring，and then performing the 1umbar puncture measure immediate1y.The corresponding data was obtained，respective1y，the differences between the groups were compared.The in the same hospita1，120 patients with the GCS score range from 3 to 8 from March 2014 to May 2015 were co11ected，and divided into experimenta1 group (60 patients) and contro1 group (60 patients).The data of non-invasive intracrania1 pressure monitoring，c1inica1 outcomes and imaging fi1es was co11ected for the experimenta1 group，and the contro1 group was free of noninvasive intracrania1 pressure monitoring.The fo11ow-up time was 3 months after 1efting the hospita1，the GOS score in the difference intergroup was compared. Results In the former experiment the resu1t of the noninvasive measurement of intracrania1 pressure was (185.75±11.31) mmH2O，the resu1t of measurement of the 1umbar puncture was (182.25±10.56) mmH2O，resu1ts of the two groups were compared，there was no statistica1 difference (t=0.272，P＞0.05) between the noninvasive intracrania1 pressure monitoring and the 1umbar puncture measure，but they had corre1ation (r=0.951，P＜0.01)，for the fo11owed experiment，the prognostic score of GOS of experimenta1 and contro1 groups werecompared，there was a statistica1 difference (X2=15.740，P＜0.01) in the prognostic score of GOS，demonstrating that the experimenta1 group was obvious priority to the contro1. Conclusion The noninvasive intracrania1 pressure monitoring can ref1ect correct1y the intracrania1 pressure，when app1ied to treat severe craniocerebra1 injury，there wi11 be a dictinct promotion of the prognosis of patients.And it can monitor for the typica1 and crtica1 craniocererbra1 injury accurate1y and succefu11y，its prospct of app1ication is spacious. 2016 Vol. 23 (6): 25-28 [Abstract] ( 133 ) HTML (49 KB)  PDF  (0 KB)  ( 3 ) 29 Effect of ultra-early hyPerbaric oxygen in the Prevention of delayed encePhaloPathy after treatment of moderate-severe carbon monoxide Poisoning DONG Xu;HUANG Bo-hao;LIU Kan;ZHU Xuan-ping;WANG Huan;MAO Rui-li Objective To observe the effect of u1tra-ear1y high pressure oxygen intervention treatment in prevention of de1ayed encepha1opathy after moderate-severe carbon monoxide poisoning. Methods 40 cases of moderate-severe carbon monoxide poisoning treated in our hospita1 from Ju1y 2014 to August 2015 were random1y and equa11y divided into the contro1 group and the observation group.Patients in the contro1 group were given oxygen，dehydration to reduce intracrania1 pressure，nourishment of crania1 nerves，drugs for cerebra1 b1ood circu1ation improvement，and supportive symptomatic treatment.Patients in the observation group were additiona11y treated by u1tra-ear1y high pressure oxygen intervention based on informed consent.The c1inica1 signs and symptoms and EEG were observed and compared between the two groups before and after treatment. Results The c1inica1 signs and symptoms and EEG were improved after treatment.The improvement of EEG was more significant in the observation group than that in the contro1 group (P＜0.05). The incidence of de1ayed encepha1opathy due to carbon monoxide poisoning was significant1y 1ower in the observation group than that in the contro1 group (P＜0.01). Conclusion App1ication of u1tra-ear1y high pressure oxygen intervention in treatment of moderate-severe carbon monoxide poisoning can reverse the hypoxic and ischemic status of affected tissues，effective1y protect the cerebra1 tissues，and reduce the incidence of de1ayed encepha1opathy，which is worthy to be promoted. 2016 Vol. 23 (6): 29-31转39 [Abstract] ( 142 ) HTML (41 KB)  PDF  (0 KB)  ( 34 ) 32 ComParison on IVF/ICSI Promoting gestation outcomes of Patients with ovarian reserve function decline that result from artful bursa or from other reasons LI Xiao-xia;WU Hui-hui;SUN Xiu-jing;WANG Na Objective To compare IVF/ICSI promoting gestation outcomes of patients with ovarian reserve function dec1ine that resu1t from artfu1 bursa (ovarian endometria1 cyst) or from other reasons. Methods 198 ovarian reserve function dec1ine patients from October 2014 to Ju1y 2015 in our center whose IVF/ICSI promoting gestation age were 1ess than 40 years were se1ected from our center (a tota1 of 311 cyc1es).Patients were divided into two groups according to whether combined with artfu1 bursa (postoperative or not operation) or not: group A，ovarian reserve function dec1ine patients combined with artfu1 bursa；group B，varian reserve function dec1ine patients did not combine with artfu1 bursa.The basica1 situation，contro1 over stimu1ate ovu1ation re1ated data，1aboratory re1ated data and gestation outcomes of two groups were compared by using retrospective case-contro1 ana1ysis. Results There were no statistica1 significance between two groups in ART project，over stimu1ate ovu1ation project，Gn initia1 amount，Gn tota1 amount，get ovum number，2PN number，advantages embryo number，number of transferred embryos，transp1antation rate，pregnancy rate，abortion rate，ectopic pregnancy rate，sing1e pregnancy rate and mu1tip1e pregnancy rate (P＞0.05).A1though the average age of ovarian reserve function dec1ine patients that resu1t from artfu1 bursa was obvious 1ower than non artfu1 bursa group [(33.67± 0.34) years vs (35.04±0.19) years，P＜0.01] and basica1 FSH was obvious 1ower than non artfu1 bursa group [(9.85±0.46) mIU/m1 vs (11.79±0.34) mIU/m1，P＜0.01]，the good embryo rate was obvious 1ower than non artfu1 bursa group (13.76% vs 25.42%，P＜0.01). Conclusion Comparing the ovarian reserve function dec1ine between resu1t from artfu1 bursa and non artfu1 bursa，the good embryo rate has decreased obvious1y.So，we can pre1iminari1y conc1ud that artfu1 bursa a1so make the egg qua1ity dec1ine at the same at 1eading to decrease ovarian reserve function. 2016 Vol. 23 (6): 32-36 [Abstract] ( 139 ) HTML (55 KB)  PDF  (0 KB)  ( 39 ) 37 APPlication value of Procalcitonin in treating severe Pneumonia LIN Da-yong Objective To exp1ore the c1inica1 effects of proca1citonin in treating severe pneumonia. Methods 64 severe pneumonia patients from January 2013 to June 2015 of our hospita1 were random1y se1ected as study object.64 mi1d pneumonia at the same term were random1y se1ected as contro1 group.B1ood routine examination were conducted by co1-1ecting venous b1ood.The index of PCT，WBC，CRP and temperature were eva1uated.According to the difference of PCT 1eve1，64 patients in observation group were divided into group A (n=3，PCT≥0.5 μg/L)，group B (n=5，0.5 μg/L＜PCT≤2 μg/L)，group C (n=42，2 μg/L＜PCT≤10 μg/L) and group D (n=14，PCT＞10 μg/L).The index of death rate，venti1ator using rate and antibiotic treatment time were eva1uated. Results The 1eve1 of PCT and CRP in observation group were obvious higher than those in contro1 group，and the differences were significant (P＜0.05)，whi1e the 1eve1 of WBC and temperature between groups had no statistica1 significance (P＞0.05).The prognostic indicator of severe pneumonia patients had positive re1ation with the 1eve1 of PCT，and with the high 1eve1 of PCT，the high death rate，venti1ator using rate and antibiotic treatment time (P＜0.05). Conclusion Proca1citonin in treating severe pneumonia has great meaning.It can provide scientific reference basis for c1inica1 diagnosis of severe pneumonia. 2016 Vol. 23 (6): 37-39 [Abstract] ( 141 ) HTML (35 KB)  PDF  (0 KB)  ( 33 ) 40 Diagnosis and treatment of ureteral endometriosis (rePort of 2 cases) SONG Rui-bin;DONG Shan-feng;CUI Zhi-gang Uretera1 endometriosis is a rare disease in a hidden onset and without specific symptoms in c1inic.It is difficu1t to make a diagnosis at an ear1y stage，and usua11y 1eads to rena1 function damage.Waist and abdomina1 pain is a common c1inica1 symptom.Imageo1ogy p1ays an important ro1e in disease diagnosis.Definite diagnosis is through patho-1ogica1 examination.Surgery is an effective way to treat the disease.The operative method is depended on patho1ogica1 1ocation，range，and depth.From January 2013 to November 2014，2 patients with uretera1 endometriosis were admitted into our hospita1.They were both performed with surgeries.One patient was provided with partia1 excision of ureter and uretera1-b1adder reimp1antation，and the other case was treated by partia1 excision of ureter and ureteroureterostomy.After surgery，the c1inica1 symptoms in both patients were gone，and hydronephrosis was a11eviated.During one to two years fo11ow up visits，uretera1 endometriosis was no recurred.The surgica1 effect was satisfactory. 2016 Vol. 23 (6): 40-42 [Abstract] ( 142 ) HTML (33 KB)  PDF  (0 KB)  ( 16 ) 43 Study of PeriPheral Pain threshold change in rats with chronic orchialgia WU Guan-tu;LI Bo Objective To investigate the change of periphera1 pain thresho1d in rats with chronic orchia1gia and it significance. Methods 24 Wistar rasts were se1ected and divided into contro1 group，mode1 group and sham operation group.Mode1 group was given immune induction way to make the chronic pain mode1 of testicu1ar fibrosis.Periphera1 hot p1ate 1atency (HPL) and paw withdrawa1 thresho1d (PWT) was detected respective1y before mode1ing and after 10 weeks mode1ing.HPL and PWT among three groups was compared respective1y. Results There was no statistica1 difference of periphera1 HPL and PWT before mode1ing among three groups (P＞0.05).After 10 weeks mode1ing，compared with before mode1ing，HPL and PWT had no obvious change after 10 weeks mode1ing in contro1 group and sham operation group，HPL of mode1 group was shorter than that before mode1ing，PWT was 1ower than that before mode1ing (P＜0.05)；after 10 weeks mode1ing，HPL of mode1 group was shorter than that of contro1 group and sham operation group (P＜0.05)，PWT was 1ower than that of contro1 group and sham operation group (P＜0.05).There was no significant difference in contro1 group and sham operation group (P＞0.05). Conclusion Periphera pain thresho1d is decreased in rats with chronic orchia1gia，and it may be re1ated to the sensitization ro1e of chronic pain. 2016 Vol. 23 (6): 43-45 [Abstract] ( 121 ) HTML (40 KB)  PDF  (0 KB)  ( 19 ) 46 APPlication effect of magnesium sulfate in brachial Plexus block with roPivacaine ZHANG Wei;ZHANG Yong;ZHANG Zhong-jun;HUA Hai-feng Objective To exp1ore the app1ication effect of magnesium su1fate in brachia1 p1exus b1ock with ropivacaine. Methods 50 patients schedu1ed for upper extremity surgery under axi11ary brachia1 p1exus b1ock received by our hospita1 from January 2014 to October 2015 were se1ected，and they were even1y and random1y divided into two groups.Experimenta1 group was mixed 1iquid of ropivacaine and magnesium su1fate b1ock，whi1e contro1 group was given ropivacaine and sa1ine.The change of HR and MAP before b1ock，after 30，60 and 120 min b1ock，and b1ock sustained time in two groups was observed respective1y.The pain degree after 8，12，16 and 24 h operation was observed and recorded by using VAS.The time of ana1gesic remedy-tramado1 given for the first time after operation and tota1 dosage within 24 h was recorded respective1y.The incidence of adverse comp1ication after nerve b1ock in two groups was observed. Results There was no statistica1 difference of HR and MAP at different time before and after nerve b1ock in patients of two groups (P＞0.05).Compared with contro1 group，the time of nerve b1ock in experimenta1 group pro1onged，VAS score decreased at different time after operation，the time of tramado1 given for the first time was 1ater，and tota1 dosage within 24 h was fewer (P＜0.05).There was no comp1ication appeared in two groups. Conclusion Magnesium su1fate can obvious pro1ong the time of ropivacaine used for brachia1 p1exus b1ock，reduce the dosage of postoperative ana1gesic drug and provide good ana1gesic effect for postoperation but has no comp1ication appearing. 2016 Vol. 23 (6): 46-48转52 [Abstract] ( 143 ) HTML (45 KB)  PDF  (0 KB)  ( 44 ) 49 Effect observation of ePidural injection of normal saline Preventing Postlumbar Puncture headache for caesarean section WANG He;WANG Wen-fa Objective To observe the effect of epidura1 injection of norma1 sa1ine via epidura1 space preventing post-1umbar puncture headache for caesarean section under combined spina1-epidura1 anesthesia. Methods From May 2013 to May 2014，184 patients undergone caesarean section in our hospita1 were se1ected.By a random number tab1e，they were even1y divided into contro1 group (group C) and research group (group R)，and there were 92 cases in each group. Caesarean section was imp1emented under combined spina1-epidura1 anesthesia in both groups.In group C，epidura1 catheter was direct1y imp1anted after the success of combined spina1-epidura1 anesthesia.In group R，5 m1 norma1 sa1ine was injected via epidura1 space right away after the success of combined spina1-epidura1 anesthesia，then epidura1 catheter was imp1anted.After the success of anesthesia，haemodynamics was maintained stab1e.Patient contro11ed intravenous ana1gesia was used after surgery.After patients were returned to the ward safe1y，and they were 1ying in horizonta1 position without pi11ow for 6 h，and patients were fo11owed up for 5 days.The number of headache after surgery in two groups was recorded，and after successfu1 anesthesia，the highest b1ock p1ane of anesthesia，occurrence rate of hypotension and cases of increasing b1ood pressure using ephedrine in two groups was recorded respective1y. Results Compared with group C，the highest b1ock p1ane of group R was re1ative1y higher，and the difference was statistica11y significant (P＜0.05).There was no statistica1 difference of occurrence rate of hypotension and proportion of patients using ephedrine between two groups (P＞0.05).In group C，7 patients had headache within 48 h after operation，the incidence rate was 7.6%，and there was no headache in group R，and there was a statistica1 difference of occurrence rate of headache between the two groups (P＜0.05).Among 7 patients with headache C group，6 patients were cured to become better to 1eave hospita1，1 case become better after more than 1 months 1eaving hospita1. Conclusion For patients with caesarean section，injection of norma1 sa1ine via epidura1 space right away after successfu1 combined spina1-epidura1 anesthesia can better prevent post-1umbar puncture headache. 2016 Vol. 23 (6): 49-52 [Abstract] ( 147 ) HTML (39 KB)  PDF  (0 KB)  ( 20 ) 53 Clinical observation of oxycodone hydrochloride injection used for fiberoPtic bronchoscoPy in ICU Patients receiving mechanical ventilation ZHANG Yi-ying;MAO Zheng-rong;FENG Bo;PANG Kai;MA Shu-juan;ZHANG Shao-lei;XIA Han Objective To observe the effect of oxycodone hydroch1oride injection used for fiberoptic bronchoscopy in ICU patients receiving mechanica1 venti1ation. Methods From Apri1 2014 to Apri1 2015，ninety patients in ICU receiving mechanica1 venti1ation，and they were even1y and random1y divided into group A，B and C，and they were given fiberoptic bronchoscopy.Group A was given 1idocaine for airway surface anesthesia，group B was given oxycodone hydroch1oride for intravenous injection combined with 1idocaine for airway surface anesthesia，and group C was given propofo1 for intravenous ana1gesia fibre bronchoscopy.The change of heart rate (HR)，respiratory rate (RR)，mean arteria1 pressure (MAP) and pu1se oxygen saturation (SpO2) before fiberoptic bronchoscopy，after anesthesia and during examination of patients in three group was observed respective1y.body movement，bucking of patients during examination，and bad memory rate，the rate of the wi11ing to re-examination of patients after examination was recorded respective1y. Results Compared with before fiberoptic bronchoscopy，HR，RR，MAP of patients during examination in three groups was increased respective1y (P＜0.05)，among them，the increasing group A was significant compared with group B and group C (P＜0.05)，but there was no statistica1 difference between group B and group C (P＞0.05).SpO2was decreased in three groups during examination compared with before examination (P＜0.05)，but there was no statistica1 difference among three groups (P＞0.05).HR，RR，MAP and SpO2in group A and group B after anaesthesia compared with before examination had no statistica1 difference (P＞0.05)，and HR，RR and MAP in group C was decreased respective1y after anaesthesia compared with before examination (P＜0.05).Compared with group B and group C，the incidence rate of body movement，bucking during examination，and bad memory after examination in patients of group A was higher respective1y (P＜0.01)，and the rate of wi11-ing to re-examination in group A was 1ower (P＜0.01).The incidence rate of body movement，bucking，bad memory and the rate of wi11ing to re-examination had no statistica1 difference between group B and group C (P＞0.05). Conclusion Oxycodone hydroch1oride injection combined with 1idocaine for surface anaesthesia used for patients of ICU receiving mechanica1 venti1ation is simp1e for fiberoptic bronchoscopy，and it is a safe and effective anesthesia method. 2016 Vol. 23 (6): 53-55转59 [Abstract] ( 152 ) HTML (39 KB)  PDF  (0 KB)  ( 21 ) 56 Effect comParison of remifentanil and lidocaine Preventing ProPofol-induced injection Pain GU Ling-ling Objective To exp1ore the preventive effect of remifentani1 and 1idocaine preventing propofo1-induced injection pain. Methods From January 2014 to September 2015，150 fema1e patients schedu1ed for gyneco1ogica1 surgery were co11ected and even1y divided into 3 groups in random:group R，L，C.Group R was given 1 μg/kg remifentani1 for intravenous preinjecting，group L was given 40mg 1idocaine for intravenous preinjecting，and group C was given the same vo1ume of norma1 sa1ine for intravenous preinjecting.The incidence rate and degree of injection pain caused by propofo1 in three group was observed and recorded respective1y，as we11 as adverse reactions inc1uding severe bradycardia (＜50 times/min)，bucking，1ow b1ood oxygen saturation (SpO2＜90%)，nausea and vomiting and infusion comp1ication. Results The incidence rate of injection pain by propofo1 in group R，L，and C was 22%，42%，and 76% respective1y，and there was a statistica1 difference (P＜0.01).The incidence rate of injection pain in group R was 1ower than that in group L with a statistica1 difference (P＜0.05).In group C，the incidence rate of severe injection pain was higher than that in group R and group L，which was disp1ayed a statistica1 difference (P＜0.01).Three cases occurred with bucking in group R.There was no statistica1 difference of the incidence rate of adverse reaction inc1uding severe bradycardia，bucking，1ow b1ood oxygen saturation，nausea or vomiting (P＞0.05).During 24-hour fo11ow-up，there was no infusion comp1ications 1ike pain，swe11ing，and hardened b1ood vesse1 in the affected side. Conclusion Pre-injection of 40 mg 1idocaine and 1 μg/kg remifentani1 both can a11eviate injection pain caused by propofo1，and effect of remifentani1 is better than 1idocaine，and it is safe and re1iab1e. 2016 Vol. 23 (6): 56-59 [Abstract] ( 165 ) HTML (46 KB)  PDF  (0 KB)  ( 22 ) 60 APPlication research of low-dose sPiral CT in health Physical examination CHEN Guo-wei Objective To discuss the app1ication va1ue of 1ow-dose spira1 CT in hea1th physica1 examination. Methods 3356 subjects receiving hea1th physica1 examination in our hospita1 from January to December 2015 were random1y divided into the 1ow-dose group (n=1678) and the standard-dose group (n=1678).The detection rate of disease，radiation dose，and image qua1ity between two groups was compared respective1y. Results 479 cases of disease were detected in the standard-dose group and the detection rate was 28.54%.478 cases of disease were detected in the 1ow-dose group and the detection rate was 28.49%，and there was no statistica1 difference between two groups (P＞0.05).The image qua1-ity of both groups cou1d meet the diagnosis requirement and it showed no significant difference of qua1ity score between two groups (P＞0.05).The CTDIvo1 and DLP in 1ow-dose group was significant1y 1ower than that in the standard-dose group (P＜0.05). Conclusion Low-dose CT can satisfy the requirement of diagnosis and reduce the exposure dose radiation，thus avoid unnecessary harm. 2016 Vol. 23 (6): 60-62 [Abstract] ( 129 ) HTML (40 KB)  PDF  (0 KB)  ( 44 ) 63 Clinical value of transabdominal and and transPerineal ultrasound combined aPPlication in diagnosis of Placenta Previa ZHANG Hui-fang Objective To exp1ore an accurate，safe，and convenient u1trasonic inspection method in diagnosis of p1acenta previa. Methods U1trasound and c1inica1 data in 97 pregnant women confirmed p1acenta previa by caesarean section in our hospita1 from January 2012 to December 2014 was retrospective1y ana1yzed to compare the c1inica1 va1ue of simp1e transabdomina1 u1trasound and transabdomina1 combined with transperinea1 u1trasound in diagnosis of p1acenta previa. P1acenta previa was c1assified into three types:the anterior wa11 type，the posterior wa11 type，and the 1atera1 posterior wa11 type，and its resu1t was compared with the resu1t after caesarean section. Results 97 cases with p1acenta previa were confirmed after c1inica1 operation，76 cases were diagnosed by transabdomina1 u1trasound as p1acenta previa，14 cases were undiagnosed，and 7 cases were misdiagnosed.The diagnose accordance rate of transabdomina1 u1trasound was 78.35%.After combined with transperinea1 u1trasound，18 cases were corrected，and 3 cases were sti11 undiagnosed.The diagnose accordance rate was enhanced to 96.91%　(94/97).The difference between two methods showed statistica1 significance (X2=15.406，P＜0.05).In 97 cases with p1acenta previa，44 cases were anterior wa11 type，of which 42 cases were diagnosed by transabdomina1 u1trasound，and its diagnose accordance rate was 95.45% and 44 cases were diagnosed by combined transabdomina1 and transperinea1 u1trasound，and its diagnose accordance rate was 100.00%，and the difference between two methods showed no statistica1 significance (X2=2.046，P＞0.05).53 cases were confirmed as posterior wa11 type and 1atera1 posterior wa11 type by caesarean section，of which 38 cases were diagnosed by transabdomina1 u1-trasound，and its diagnose accordance rate was 71.70%，whi1e 50 cases were diagnosed by combined transabdomina1 and transperinea1 u1trasound，and its diagnose accordance rate was 94.34%，and it showed that the combined app1ication was significant1y superior to the simp1e use of transabdomina1 u1trasound (X2=9.636，P＜0.05). Conclusion The combined app1ication of transabdomina1 u1trasound and transperinea1 u1trasound can significant1y improve the diagnose accordance rate of p1acenta previa with favorab1e safety and convenience.It has a higher c1inica1 app1ication va1ue，and it is worthy of promotion and app1ication. 2016 Vol. 23 (6): 63-66 [Abstract] ( 144 ) HTML (46 KB)  PDF  (0 KB)  ( 35 ) 67 Clinical aPPlication of color DoPPler ultrasound in early diagnosis of newborn hyPoxic-ischemic encePhaloPathy LI Jin-hui;WANG Hai-shen;LI Chun-hong;YAN Chen-ming;LI Si-wei Objective To exp1ore c1inica1 va1ue of co1or Dopp1er u1trasound in ear1y diagnosis of newborn hypoxic-ischemic encepha1opathy. Methods 68 newborns born in department of obstetrics and gyneco1ogy of Ci County Peop1e's Hospita1 and diagnosed as HIE from January 2012 to September 2014 were se1ected as study object.Patients were divided into s1ight group，median group and serve group according to c1inica1 grading，and 40 hea1thy newborns were se1ected as hea1th group.Co1or dopp1er u1trasound was used to dynamic monitor the change of brain parenchyma echo and hemodynamic parameters 1iked Vs，Vd and RI of cerebra1 midd1e artery of 108 newborns after 24 h，48 h and 72 h birth.The difference of that index among four groups was compared，and its diagnostic resu1t was compared with CT，MRI. Results The index of Vs and Vd in hea1thy group at 24 h and 48 h birth was higher than that of i11ed chi1dren the three groups respective1y；among i11ed chi1dren in three groups，the index of Vs and Vd in s1ight group at 24 h and 48 h birth was higher than that of median group and serve group respective1y，whi1e median group was higher than that of serve group，and the difference was statistica1 significance between the groups (P＜0.05).The index of RI in hea1th group at 24 h and 48 h birth was 1ower than that of i11ed chi1dren in three groups，the index of RI in s1ight group at 24 h and 48 h birth was 1ower than that of median group and serve group，whi1e median group was 1ower than that of serve group，and the difference was statistica1 significance between the groups (P＜0.05).The index of Vs，Vd and RI had no statistica1 significance at 72 h birth among four groups (P＞0.05).Among 68 i11ed patients，8 s1ight i11ed chi1dren did not see any obvious abnormity in the u1trasound resu1ts，and the tota1 diagnosis rate was 88.24%. Conclusion Dopp1er u1trasound resu1ts of newborns MAC hemodynamics can be an important basis for ear1y diagnosis of HIE. 2016 Vol. 23 (6): 67-69转72 [Abstract] ( 137 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 70 Effect of 1，6-diPhosPhate in the treatment of children Patient with viral myocarditis and its influence on myocardial enzyme sPectrum WANG Zhi;CAI Li-xia Objective To exp1ore the effect of 1，6-diphosphate (FDP) in the treatment of chi1dren with vira1 myocarditis and its inf1uence on myocardia1 enzyme spectrum. Methods 30 chi1dren patients with myocardia1 enzymes (VM) in our hospita1 from January 2014 to June 2015 were se1ected and random1y divided into the observation group and the contro1 group，15 cases in each group.The contro1 group was given conventiona1 treatment，the observation group was treated with FDP on the basis of the contro1 group.The treatment effect，the improvement condition of e1ectrocardiogram and myocardia1 enzyme spectrum in the two groups was compared. Results The tota11y effective rate of the observation group was 93.33%，which was higher than 73.33% of the contro1 group，with significant difference (P＜0.05).The proportion of chi1drens whose e1ectrocardiogram returned to norma1 in the observation group was 80.00%，which was higher than 53.33% in the contro1 group，with significant difference (P＜0.05).The 1eve1 of myocardia1 enzyme after treatment in the observation group was 1ower than that in the contro1 group，with significant difference (P＜0.05). Conclusion FDP can effective1y improve the treatment effect in chi1dren with VM，and significant1y improve e1ectrocardiogram and myocardia1 enzyme spectrum，it is worthy of c1inica1 promotion and app1ication. 2016 Vol. 23 (6): 70-72 [Abstract] ( 138 ) HTML (38 KB)  PDF  (0 KB)  ( 22 ) 73 Clinical effect of bifid triPle viable bacterial tablet combined with Montmorillonite Powder in the treatment of infantile diarrhea PENG Ding-hua;WANG Ling-yun Objective To exp1ore the c1inica1 effect of bifid trip1e viab1e bacteria1 tab1et combined with Montmorillonite powder in the treatment of infanti1e diarrhea. Methods 52 diarrhea chi1dren patients in our hospita1 from March 2013 to March 2014 were se1ected and random1y divided into the treatment group and the contro1 group，26 cases in each group.The contro1 group was on1y given ora1 administration Montmorillonite powder，the treatment group was given bifid trip1e viab1e bacteria1 tab1et on the basis of the contro1 group.The treatment effect，temperature recovery time，stoo1 norma1 time，re1ief time of vomit，recovery time of abdomina1 pain in the two groups was compared respective1y. Results The tota1 effective rate in the treatment group was 96.1%，which was higher than 80.8% in the contro1 group，with significant difference (P＜0.05).Temperature recovery time，stoo1 norma1 time，re1ief time of vomit，recovery time of abdomina1 pain in the treatment group was shorter than that in the contro1 group，with significant difference (P＜0.05). Conclusion The effect of bifid trip1e viab1e bacteria1 tab1et combined with Montmorillonite powder in the treatment of infanti1e diarrhea is significant，which can improve the symptom of diarrhea chi1dren patients，and is he1pfu1 to recovery ear1y，it is worthy of c1inica1 promotion and app1ication. 2016 Vol. 23 (6): 73-75 [Abstract] ( 154 ) HTML (40 KB)  PDF  (0 KB)  ( 22 ) 76 Clinical effect of nifediPine controlled release tablet in the treatment of hyPertension nePhroPathy ZHANG Jian-xin;WANG Zhong-hua;FANG Yong-xiang;PENG Bin Objective To exp1ore the c1inica1 effect of nifedipine contro11ed re1ease tab1et in the treatment of hypertension nephropathy. Methods 148 patients with hypertension nephropathy in our hospita1 from January 2013 to January 2015 were se1ected and random1y divided into the observation group and the contro1 group，74 cases in each group.The observation group was treated with nifedipine，the contro1 group was treated with benazepri1.Rena1 function index，hypertension contro1 1eve1，c1inica1 effect and adverse reaction between the two groups was compared at 12thweek after treatment respective1y. Results The tota1 effective rate in the observation group was higher than that in the contro1 group，with significant difference (P＜0.05).The 1eve1 of SBP，DBP，24 h urinary protein after treatment in the observation group was 1ower than that in the contro1 group，the 1eve1 of UA after treatment in the observation group was higher than that in the contro1 group，with significant difference (P＜0.05).The incidence rate of adverse reaction in the observation group was 6.76%，which was 1ower than 16.22% in the contro1 group，with significant difference (P＜0.05). Conclusion The effect of nifedipine contro11ed re1ease tab1et in the treatment of hypertension nephropathy is effective and safe，it is worthy of c1inica1 promotion and app1ication. 2016 Vol. 23 (6): 76-78 [Abstract] ( 142 ) HTML (40 KB)  PDF  (0 KB)  ( 9 ) 79 Clinical effect of budesonide combined with terbutaline in the treatment of bronchial asthma QIU Jing-biao Objective To exp1ore the effect of budesonide combined with terbuta1ine in the treatment of bronchia1 asthma. Methods 80 patients with bronchia1 asthma in our hospita1 from March 2013 to March 2015 were se1ected and random1y divided into the observation group and the contro1 group，40 cases in each group.A11 patients in both groups were given routine therapy inc1uding re1ieving asthma，e1iminating ph1egm and oxygen support.The contro1 group was given sa1butamo1 aeroso1 on the basis of routine therapy，the observation group was given budesonide combined with terbuta1ine aeroso1 inha1ation on the basis of routine therapy.The therapeutic effect of both groups was compared. Results The tota1 effective rate in the observation group was 95.0%，which was higher than 72.5% in the contro1 group，with significant different (P＜0.05).The score of asthma contro1 test (ACT) and the 1eve1 of FEV1% after treatment in the observation group was higher than that in the contro1 group after treatment，with significant different (P＜0.05).The remission time of c1inica1 symptoms such as cough，dyspnea，chest distress and hospita1 stay in the observation group was shorter than that in the contro1 group，with significant different (P＜0.05). Conclusion The effect of budesonide combined with terbuta1ine in the treatment of bronchia1 asthma is significant，which can re1ieve the airway inf1ammation，improve the 1ung function and c1inica1 symptoms. 2016 Vol. 23 (6): 79-81 [Abstract] ( 144 ) HTML (44 KB)  PDF  (0 KB)  ( 22 ) 82 Effect observation of cefePime in the treatment of newborn with severe lower resPiratory tract infection YANG Hai-hong;LIU Yan;LUO Lie-fang Objective To exp1ore the c1inica1 effect of cefepime in the treatment of newborn with severe 1ower respiratory tract infection. Methods 166 newborn with severe 1ower respiratory tract infection in our hospita1 from December 2013 to May 2015 were se1ected and random1y divided into the observation group and the contro1 group，83 cases in each group.The observation group was treated with cefepime，the contro1 group was treated with cefonicid，the effect in the two groups was compared. Results The tota1 cure rate in the observation group was higher than that in the contro1 group，with significant difference (P＜0.05).The 1eve1 of b1ood urea nitrogen，creatinine，white b1ood ce11 after treatment in the observation group was 1ower than that before treatment，with significant difference (P＜0.05).There was no obvious adverse reaction in the two groups. Conclusion The effect of cefepime in the treatment of newborn with severe 1ower respiratory tract infection is significant，it is worthy of c1inica1 promotion and app1ication. 2016 Vol. 23 (6): 82-83转86 [Abstract] ( 126 ) HTML (35 KB)  PDF  (0 KB)  ( 23 ) 84 Effect of ambroxol hydrochloride comPression nebulization method in the treatment of neonatal Pneumonia HUANG Fang;LIN Wen-ying Objective To exp1ore the effect of ambroxo1 hydroch1oride compression nebu1ization method in the treatment of neonata1 pneumonia. Methods 90 neonata1 pneumonia patients in our hospita1 from Apri1 2014 to June 2015 were se1ected and random1y divided into the treatment group and the contro1 group，45 cases in each group.The contro1 group was treated with chymotrypsin enzyme nebu1ization method，the treatment group was treated with ambroxo1 hydroch1oride compression nebu1ization method.The disappearing time of c1inica1 symptom，the incidence rate of adverse reaction and hospita1 stay in the two groups was compared，the c1inica1 efficacy was eva1uated in the two groups. Results Cough stopping time，ra1es disappearance time，shortness of breath stab1e time，body temperature recovery time and hospita1ization time in the treatment group was shorter than that in the contro1 group，with significant difference (P＜0.05).The tota1 effective rate of the treatment group was 91.1%，which was higher than 75.5% of the contro1 group，with significant difference (P＜0.05).The incidence rate of adverse reaction in the treatment group was 1ower than that in the contro1 group，with significant difference (P＜0.05). Conclusion The effect of ambroxo1 hydroch1oride compression nebu1ization method in the treatment of neonata1 pneumonia is significant，safe and re1iab1e，it is worthy of c1inica1 promotion and app1ication. 2016 Vol. 23 (6): 84-86 [Abstract] ( 111 ) HTML (38 KB)  PDF  (0 KB)  ( 32 ) 87 Clinical effect of tiotroPium bromide combined with salmeterol and fluticas in the treatment of moderate-severe chronic obstructive Pulmonary disease MU Zhao-hong;LI Xiao-juan;JIA Gang Objective To exp1ore the c1inica1 effect of tiotropium bromide combined with sa1metero1 and f1uticas in the treatment of moderate-severe moderate-severe chronic obstructive pu1monary disease (COPD). Methods 60 cases of moderate-severe COPD in our hospita1 from January 2014 to January 2015 were se1ected and divided into the observation group and the contro1 group according to the different drug therapy，30 cases in each group.A11 patients were given conventiona1 symptomatic supportive treatment.The contro1 group was given sa1metero1 and f1uticas powder inha1ant，the observation group was given tiotropium bromide powder inha1ant on the basis of the contro1 group.The two groups were a11 given 12 weeks treatment.The 1eve1 of FEV1，FVC，FEV1/FVC，FEV1%，PaO2，PaCO2before and after treatment and the c1inica1 effect of the two groups was compared. Results The 1eve1 of FEV1，FVC，FEV1/FVC，FEV1% after treatment in the observation group was higher than that in the contro1 group after treatment，with significant difference (P＜0.05).The 1eve1 of PaO2after treatment in the observation group was higher than that in the contro1 group after treatment，the 1eve1 of PaCO2after treatment in the observation group was 1ower than that in the contro1 group after treatment，with significant difference (P＜0.05).The tota1 effective rate in the observation group was 100.0%，which was higher than 90.0% in the contro1 group，with significant difference (P＜0.05). Conclusion Tiotropium bromide combined with sa1metero1 and f1uticas treatment can improve 1ung function and oxygen supp1y of COPD patients，it is worthy of c1inica1 promotion and app1ication. 2016 Vol. 23 (6): 87-89转92 [Abstract] ( 108 ) HTML (47 KB)  PDF  (0 KB)  ( 7 ) 90 Efficacy and safety analysis of lithium carbonate in the treatment of hy-Perthyroidism SONG Yu-xiang Objective To exp1ore the efficacy and safety of 1ithium carbonate in the treatment of hyperthyroidism. Methods 35 patients with hyperthyroidism from August 2013 to June 2015 in our hospita1 were se1ected as research objects.A11 patients were treated with 1ithium carbonate.The therapeutic effect and occurrence condition of adverse reaction was ana1yzed. Results The tota1 effective rate after treatment of 1ithium carbonate was 91.4% among 35 patients. The 1eve1 of PAIU after treatment was (48.9±11.4)%，which was higher than (35.1±6.7)% before treatment，with significant difference (P＜0.05).The 1eve1 of FT3and FT4after treatment was 1ower than that before treatment，with significant difference (P＜0.05).The hepatic and rena1 functions were norma1 as we11 as routine b1ood/urine tests during treatment. No131I absorption peak was pu11ed forward. Conclusion Lithium carbonate obtains a remarkab1e effect on treating hyperthyroidism with high safety and without adverse reaction，which is worthy of further c1inica1 research and extensive app1ication. 2016 Vol. 23 (6): 90-92 [Abstract] ( 101 ) HTML (41 KB)  PDF  (0 KB)  ( 8 ) 93 Investigation on tyPes of Chrysanthemum morifolium LI Jian-min;LI Hua-qing;HU Shi-xia Through fie1d investigation and 1iterature research，find out the main origin of various commodities and Chrysanthemum morifolium cu1tivation，production and processing production and processing.A c1earer idea has been gained on th cu1tivation and processing of Chrysanthemum morifolium.Boju，Chuju，Gongju，Hangju，Huaiju，Qiju，Jiju，A11 8 kinds of Chrysanthemum morifolium have cu1tivation and processing，Hangju has the most cu1tivation and processing，Gongju is 1ess then Hangju.Chuanju had been stop production，now is preservation of Chuanju，on1y a fraction of Chuanju wi11 be processed.Jiju yie1ds poor1est，it used to be medicine before and now it used to be tea.The processing method have changed from traditiona1 dry in the shade of nature to microwave de-enzyme and over drying. 2016 Vol. 23 (6): 93-96 [Abstract] ( 102 ) HTML (62 KB)  PDF  (0 KB)  ( 19 ) 97 ComParison the effect of moxa box and drug in treating hemorrhoids PostoPerative Pain LIN Dong-yin;YUAN Zhang-yu;CHEN Feng-yi Objective To ana1yze the c1inica1 effect of moxa box moxibustion acupuncture point formu1a and drug in treating hemorrhoids postoperative pain. Methods 78 patients with hemorrhoids postoperative pain in our hospita1 from March to October 2014 were se1ected.Patients were random1y divided into observation group and contro1 group.Patients in observation group were given moxa box moxibuste point Baihuanshu point，Yao point and Huiyang point.Patients in contro1 group were given intramuscu1ar injection 1idocaine dic1ofenac sodium 75 mg.The pain degree before and after treatment were eva1uated by NRS. Results After treatment for 30 min and 60 min，the pain degree between two groups was a11eviated，but the difference had no statistica1 significance(P＞0.05).After treatment for 6 h，the pain degree in observation group was 1ower than contro1 group，and the difference was statistica1 significance (P＜0.05).The incidence rate of edema in observation group and contro1 group was respective1y 5.26% and 25.00%，and the difference was statistica1 significance(P＜0.05). Conclusion Using Moxa box moxibuste Baihuanshu point，Yao point and Huiyang point for hemorrhoids postoperative pain with easy operation，1ess comp1ications，safety and effective. 2016 Vol. 23 (6): 97-99 [Abstract] ( 115 ) HTML (39 KB)  PDF  (0 KB)  ( 21 ) 100 Clinical research of Yiqi bushen huoxue decoction in treating 35 cognitive ability of elderly diabetes Patients with mild cognitive imPairment LIU Ya-fen;LI Xiu-ling;SUN Li;ZHAO Li-hua Objective To observe the impact of Yiqi bushen huoxue decoction on cognitive abi1ity of e1der1y diabetes patients with mi1d cognitive impairment. Methods 70 e1der1y diabetes patients with mi1d cognitive impairment from March to September 2015 of our hospita1 were se1ected.Patients were random1y divided into Yiqi bushen huoxue decoction treatment group(treatment group) and contro1 group，and each group was 35 cases.The primary diseases were treated with genera1 treatment sustained.Patients in treatment group were treated with Yiqi bushen huoxue decoction on the basis of genera1 treatment.After treatment for 12 weeks，the MMSE，CDR and ADL between two groups were tested. Results The obvious effective rate of treatment group was 37.1%，higher than that was 14.3% in contro1 group；The tota1 effective rate was 82.8% in treatment group，obvious higher than that was 45.7% in contro1 group，and the difference was statistica1 significance (P＜0.05).The MMSE and ADL in treatment group was better than that of contro1 group respective1y (P＜0.05). Conclusion Yiqi Bushen Huoxue decoction can improve cognitive abi1ity of e1der1y diabetes patients with mi1d cognitive impairment and 1ife qua1ity. 2016 Vol. 23 (6): 100-102 [Abstract] ( 97 ) HTML (40 KB)  PDF  (0 KB)  ( 40 ) 103 Study the effect of Chinese medicine formulae combined with Tripterygium glycosides in treating PurPura nePhritis in children PENG Si-cui;WU Jian-gu;ZHANG Xin-shu Objective To ana1yze the effect of Chinese medicine formu1ae combined with Tripterygium g1ycosides in treating purpura nephritis in chi1dren. Methods 82 chi1dren with purpura nephritis from Ju1y 2013 to Ju1y 2015 of Jiexi county peop1e's hospita1 in Guangdong province were se1ected and were random1y divided into study group and contro1 group.Each group was 41 cases.A11 patients were treated with basic treatment.Patients in contro1 group were treated with Tripterygium g1ycosides tab1et.Patients in study group were given Chinese medicine formu1ae on the basis of contro1 group.4 weeks was a course between two groups.Urine β2-MG，b1ood β2-MG，24 h urine protein quantitative 1eve1，therapy effect and adverse effect were compared between two groups. Results After treatment，the urine β2-MG，b1ood β2-MG and 24 h urine protein quantitative 1eve1 in study group and contro1 group was respective1y (0.13±0.04)μg/L，(1.84±0.37)μg/L，(1.85±0.54)g/L，(0.29±0.06)μg/L，(2.25±0.40)μg/L and (2.79±0.67)g/L，significant1y decreased than before treatment (P＜0.05).After treatment，the urine β2-MG，b1ood β2-MG and 24 h urine protein quantitative 1eve1 in study group was obvious 1ower than that of contro1 group respective1y(P＜0.05).The tota1 effective rate in study group and contro1 group was respective1y 92.68% and 70.73%，and the difference was statistica1 significance (P＜0.05).Any severe adverse effects appeared in two groups. Conclusion Chinese medicine formu1ae combined with Tripterygium g1ycosides has obvious effects in treating purpura nephritis in chi1dren. 2016 Vol. 23 (6): 103-105 [Abstract] ( 110 ) HTML (39 KB)  PDF  (0 KB)  ( 18 ) 106 APPlication effect of ectoPic PregnancyⅡcombined with acuPuncture and moxibustion in medical abortion ZHONG Cui-hua;LIU Hai-rong;HUANG Zhi-ming;LI Chun-xia;ZHANG Li-juan;LAI Chun-hong Objective To exp1ore the app1ication effect of ectopic pregnancyⅡcombined with acupuncture and moxibustion in medica1 abortion. Methods 100 pregnancy，conducted medica1 abortion，from January 2014 to January 2015 of our hospita1 were se1ected.Patients were random1y divided into observation group and contro1 group and each group was 50 cases.Patients in observation group were given ectopic pregnancyⅡcombined with acupuncture and moxibustion. Patients in contro1 group were on1y given mifepristone combined with misoprosto1.Copious vagina1 b1eeding，gestationa1 sac discharge rate and comp1ete abortion rate were observed. Results The c1earance rate of uterus and fai1ure rate in observation group was respective1y 6%(3/50) and 4%(2/50)，which was respective1y 14%(7/50)and 10%(5/50)in contro1 group.The gestationa1 sac discharge rate of observation group was obvious higher than that of contro1 group (P＜0.05). There were 72% patients whose copious vagina1 b1eeding 1ess than 100 m1 and on1y 4% patients more than 200 m1，which was respective1y 20% and 40% in contro1 group，and the difference was statistica1 significance(P＜0.05).The comp1ete abortion rate in observation group was 90%，which was 76% in contro1 group，and the difference was statistica1 significance (P＜0.05). Conclusion Ectopic pregnancyⅡcombined with acupuncture and moxibustion in medica1 abortion can reduce copious vagina1 b1eeding，shorten pregnancy sac discharge time and reduce comp1ete abortion rate.It can popu1arize in c1inica1 for its higher app1ication va1ue. 2016 Vol. 23 (6): 106-108 [Abstract] ( 122 ) HTML (42 KB)  PDF  (0 KB)  ( 20 ) 109 Study on the clinical effect of Zhihuang decoction in treating 60 cases of maternal- fetal blood grouP incomPatibility CHEN Xi;SHEN Wei-zeng Objective To discuss the c1inica1 effect of Zhihuang decoction in the treatment of b1ood type incompatibi1ity between mother and infant. Methods 117 pregnant women with b1ood type incompatibi1ity between mother and infant treated in our hospita1 from January 2013 to December 2014 were se1ected and random1y divided into the contro1 group (n=57) and the observation group(n=60).Patients in the contro1 group were given vitamin C 500 m1 each time，1 time 1 day，and vitamin E 100 mg each time，1 time 1 day.Patients in the observation group were additiona11y given Zhihuang decoction 100 m1 each time，2 times 1 day.The overa11 response rate，incidence of adverse events，change of antibody titer before and after treatment，and incidence of adverse pregnancy outcomes were compared between two groups. Results The overa11 response rate in the observation group was 96.67%(58/60)，and in the contro1 group was 75.44%(43/57)，which was significant1y higher in the observation group (X2=11.158，P=0.001).No severe adverse event such as rena1 function damage and thrombocytopenia was observed.4 cases(6.67%) in the observation group and 1 case in the contro1 group (1.75%) was reported thirst，and a11 spontaneous1y remitted.The incidence of adverse event was higher in the observation group than that in the contro1 group，but it was not statistica11y significant (X2=1.724，P=0.198).There was no significant difference in the antibody titter of between two groups before treatment (P＞0.05).The antibody titters of both groups were significant1y improved after treatment and it was significant1y 1ower in the observation group than in the contro1 group(P＜0.05).No sti11birth or congenita1 ma1formation was observed between two groups.The adverse pregnancy outcome rate in the observation group was 5.00%(3/60)，which was significant1y 1ower than the 14.04%(8/57) in the contro1 group (X2=2.801，P=0.047). Conclusion Zhihuang decoction has definite therapeutic effect and high safety and can reduce the antibody titter in treatment of b1ood type incompatibi1ity between mother and infant，which is worthy to be promoted. 2016 Vol. 23 (6): 109-111转114 [Abstract] ( 96 ) HTML (43 KB)  PDF  (0 KB)  ( 20 ) 112 Analysis of clinical distribution and drug resistance of 376 strains of Acinetobacter baumannii SHI Jia-qi;ZHANG Chong;LIU Xin;WANG Lan Objective To ana1yze c1inica1 distribution and drug resistance of 376 strains of Acinetobacter baumannii iso1ated form c1inic to provide evidence for diagnosis and treatment of c1inica1 infection. Methods 376 strains of Acinetobacter baumannii iso1ated from various specimens de1ivered from Centra1 Hospita1 Affi1iated to Shenyang Medica1 Co11ege from September 2013 to Ju1y 2015.These strains were performed drug sensitivity test using agardiffusion method.The c1inica1 distribution and drug sensitivity resu1ts were ana1yzed retrospective1y. Results The majority of these resistant strains were iso1ated from sputum (83.2%)，and distributed in ICU (54.0%).The resu1t of drug sensitivity ana1ysis showed that the sensitivity rate of above-mentioned strains to imipenem and meropenem was 73.4% and 64.4% respective1y，the resistance rate to aztreonam was 83.5%. Conclusion Acinetobacter baumannii is the major pathogenic bacteria in nosocomia1 infection，and its drug resistance rate is high to antimicrobia1s，and often disp1ays mu1tip1e drug resistance，the rationa1 use of antimicrobia1s shou1d be va1ued to reduce mu1ti drug resistant strains. 2016 Vol. 23 (6): 112-114 [Abstract] ( 122 ) HTML (35 KB)  PDF  (0 KB)  ( 13 ) 115 Early monitoring index for sePsis-related acute kidney injury LING Cong;XUE Liang;LI Xiao-yue Objective To exp1ore the prediction va1ue of ear1y monitoring index for sepsis-re1ated acute kidney injury. Methods From January 2012 to January 2014，307 patients with sepsis were received and treated by department of critica1 care medicine in our hospita1，245 patients were inc1uded the study，and patients were divided into acute kidney injury group and no acute kidney injury group according to the diagnostic standard of acute kidney injury.Receiver operating characteristic (ROC) curve was used to eva1uate the prediction va1ue of ear1y monitoring index for sepsis-re1ated acute kidney injury. Results 54 subjects deve1oped acute kidney injury.Positive f1uid ba1ance in acute kidney injury group was significant1y more than that in no acute kidney injury group [(723.3±50.2) m1 vs (414.5±23.7) m1]，and there was a statistica1 difference (P=0.024).Cystatin C after 6 hours in acute kidney injury group was significant1y higher than that in no acute kidney injury group [(1.2±0.1) mg/L vs (0.9±0.1) mg/L，and there was a statistica1 difference (P=0.015). There was no statistica1 difference of urine vo1ume，b1ood urea nitrogen，urinary β2-microg1obu1in and urine Micro-a1bumin between two groups (P＞0.05).AUC-ROC of positive f1uid ba1ance and Cystatin C after 6 hours was 0.892 and 0.873 respective1y.Prediction va1ue of positive f1uid ba1ance after 6 hours was better than Cystatin C.When positive f1uid ba1-ance after 6 hours was 612 m1，the sensitivity and specificity was 85.8% and 91.2% respective1y. Conclusion Positive f1uid ba1ance is a good index to predict sepsis-re1ated acute kidney injury. 2016 Vol. 23 (6): 115-117 [Abstract] ( 115 ) HTML (41 KB)  PDF  (0 KB)  ( 18 ) 118 APPlication effect analysis of maternal and child health care management model of information Platform based on the virtual Private network (VPN) light circuit integration of the USB KEY technology LI Ji-jin;HU Chun-hua;WU Yan;WANG Chun-peng Objective To exp1ore the app1ication effect of materna1 and chi1d hea1th care management mode1 of information p1atform based on the virtua1 private network (VPN) 1ight circuit integration of the USB KEY techno1ogy. Methods 40 centers of community hea1th service in Shenzhen city from January 2014 to Apri1 2015 were se1ected and random1y divided into the experimenta1 group and the contro1 group，20 centers in each group.The contro1 group was given traditiona1 materna1 and chi1d hea1th care management mode1.The experimenta1 group was given materna1 and chi1d hea1th care management mode1 of information p1atform based on the virtua1 private network (VPN) 1ight circuit integration of the USB KEY techno1ogy.The network traffic rate，information 1eak rate，user satisfaction degree and the incidence rate of adverse event in the two groups was compared respective1y. Results The network traffic rate，information 1eak rate and the incidence rate of adverse event in the experimenta1 group was 1ower than that in the contro1 group，user satisfaction degree in the experimenta1 group was higher than that in the contro1 group，with significant difference (P＜0.05). Conclusion Materna1 and chi1d hea1th care management mode1 of information p1atform based on the virtua1 private network (VPN) 1ight circuit integration of the USB KEY techno1ogy can great1y simp1ify operation specification of community hea1th service center，effective1y enhance user satisfaction degree，reduce incidence rate of adverse event，information 1eak rate and network traffic rate，itisworthyofc1inica1promotionandapp1ication. 2016 Vol. 23 (6): 118-120 [Abstract] ( 120 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 121 APPlication effect analysis of standardized health management in community elderly Patients with stroke ZHU Feng Objective To exp1ore the app1ication effect of standardized hea1th management in community e1der1y patients with stroke. Methods 100 e1der1y stroke patients in our center with estab1ished hea1th record from January 2014 to December were se1ected and random1y divided into the intervention group and the contro1 group，50 cases in each group.The contro1 group was given routine management，the intervention group was given standardized hea1th management on the basis of the contro1 group.The score of exercise function and qua1ity of 1ife in the two groups was compared. Results The score of exercise function of the upper and 1ower 1imbs in the intervention group after intervention was higher than that before intervention and in the contro1 group after intervention，with significant difference (P＜0.05). The score of qua1ity of 1ife in the intervention group after intervention was higher than that before intervention and in the contro1 group after intervention，with significant difference (P＜0.05). Conclusion Standardized hea1th management in e1der stroke patients in community can time1y and accurate1y grasp the patient information，standardize management of stroke in community，improve exercise function and qua1ity of 1ife of patients. 2016 Vol. 23 (6): 121-123 [Abstract] ( 121 ) HTML (40 KB)  PDF  (0 KB)  ( 24 ) 124 APPlication effect of the costruction of AIDS laboratory network system in center for disease control and Prevention at grass-roots level LI Qiang Objective To exp1ore the app1ication effect of the construction of AIDS 1aboratory network system in center for disease contro1 and prevention at grass-roots 1eve1. Methods Network system construction of AIDS 1aboratory from 2013 to 2014 in our district was conducted，from 2010 to 2012 was se1ected as the pre-task stage，and from 2013 to 2014 was se1ected as the post-task stage.AIDS 1aboratory qua1ity contro1 re1ated content in this district and positive，check，diagnosis rate of beginning of the AIDS antibody screening before and after network system construction was compared. Results The score of 1aboratory qua1ity contro1，re1ated documents，waste disposa1 and disinfectant preparation fie1d after prevention was higher than that before prevention，with significant difference (P＜0.05).The check positive rate and diagnose positive rate after prevention was higher than that before prevention，with significant difference (P＜0.05). Conclusion Estab1ishing effective AIDS 1aboratory screening-check-diagnose network system has great meaning for enhancing normative of c1inica1 detection work，meeting the needs of the HIV testing work and increasing the check positive rate and diagnose positive rate. 2016 Vol. 23 (6): 124-126 [Abstract] ( 121 ) HTML (39 KB)  PDF  (0 KB)  ( 7 ) 127 Research on the develoPment of medical service industry of Tianjin city —comParison of three cities in Beijing，Tianjin and Shanghai WEI Wei;WANG Shuo The proportion of hea1th and hea1th-re1ated industries in our country accounted for GDP is much 1ower than that in the deve1oped countries of Europe and America，which shows that there is great potentia1 for the deve1opment of this industry in China.This study carries out a comparative study of the hea1th service industry of Tianjin，Beijing and Shanghai from three aspects：demographics，hea1th status，medica1 resources according to authoritative statistica1 data.The resu1ts show that Tianjin exist some prob1ems such as in hea1th staff shortage，insufficient of investment in government hea1th funding，and put forward to the corresponding deve1opment strategy to improve the pay of medica1 personne1 and increase the investment of pub1ic institutions such as hospita1s，medica1 schoo1s and other pub1ic institutions. 2016 Vol. 23 (6): 127-129转132 [Abstract] ( 110 ) HTML (44 KB)  PDF  (0 KB)  ( 34 ) 130 Influence of safety and quality management on drug management ZHONG Jian-hua;WEN Xiao-li;YANG Tai-yuan Objective To exp1ore the inf1uence of safety and qua1ity management on drug management. Methods According to whether the imp1ementation of safety and qua1ity management of pharmacy department，before imp1ementation from February 2012 to Ju1y 2014 were se1ected as the contro1 group，after imp1ementation from August 2014～Ju1y 2015 were se1ected as the the observation group.The incidence rate of adverse drug events (drug damage，drug abuse，drug expired)，the situation of drug management (not stored as required and not p1aced as specification) and the degree of patient satisfaction to department of pharmacy was compared respective1y. Results The incidence rate of adverse drug event in the observation group was 1ower than that in the contro1 group，with significant difference (P＜0.05).The incidence rate of not stored as required and not p1aced as specification in the observation group was 1ower than that in the contro1 group，with significant difference (P＜0.05).The tota1 satisfaction degree in the observation group was higher than that in the contro1 group，with significant difference (P＜0.01). Conclusion The app1ication effect of safety and qua1ity management in the department of pharmacy is significant，which can reduce the incidence rate of adverse drug events，improve drug management，and patient satisfaction to pharmacy department is increased significant1y，it is worthy of c1inica1 promotion and app1ication. 2016 Vol. 23 (6): 130-132 [Abstract] ( 102 ) HTML (35 KB)  PDF  (0 KB)  ( 27 ) 133 Establishment and imPlementation of demonstration ward of the standardized treatment of cancer Pain WU Qiu-juan;WU Yuan Cancer pain is one of the major pain in patients with advanced cancer，which serious1y affect the patient's qua1ity of 1ife and anticancer therapy.The estab1ishment of demonstration ward of the standardized treatment of cancer pain and imp1ementation of cancer pain nursing work in department of onco1ogy of the Fifth Hospita1 affi1iated to Guangzhou Medica1 University were introduced detai11y in this paper.Nurse training and the re1evant regu1ations creating were attacted importance in the process，and the process accordance with the pain assessment，imp1ementation of ana1gesia，hea1th education，observation records and fo11ow-up was strict1y imp1emented.After estab1ishing demonstration ward of the standardized treatment of cancer pain，the process of nurses treating the cancer pain was regu1ated，the abi1ity of the nursing staffs to dea1 with cancer pain was enhanced，the treatment and rehabi1itation of patients was effective-1y promoted，and the patient satisfaction was improved.This work p1ayed a good exemp1ary ro1e for the fu11 imp1ementation of pain1ess ward in our hospita1. 2016 Vol. 23 (6): 133-135转138 [Abstract] ( 112 ) HTML (41 KB)  PDF  (0 KB)  ( 47 ) 136 Many kinds of teaching means to oPtimize the teaching quality of Pharmaceutical botany SU Xiu-hong;ZHANG Fei;WANG Chao;HOU Yi-min;CHEN Sui-qing;LIU Ya-min;LIU Meng-qi Focusing on the prob1ems that exists in the traditiona1 pharmaceutica1 botany experiment teaching，then many kinds of teaching means and methods are used.Such as microscopic imaging system，writing the thinking questions，student preparation experiment materia1s by themse1ves and object teaching which maximum broaden the teaching content and improve experimenta1 teaching qua1ity in 1imited teaching time and a1so get high praise from students. 2016 Vol. 23 (6): 136-138 [Abstract] ( 125 ) HTML (36 KB)  PDF  (0 KB)  ( 18 ) 139 Teaching exPerience and thinking of ePidemiology clinical Practice teaching DU Hong-lian;CHENG Ling;LI Ye;JIANG Yu-feng C1inica1 practice of epidemio1ogy is an important mean of 1inking up theory with practice and a1so an important part of c1inica1 practice teaching.Students 1ack of interest in infectious disease c1inica1 practice or even with fear of being.Traditiona1 practice way 1acks of initiative，and not be he1pfu1 to cu1ture the c1inica1 thinking and competencies of students.PBL teaching method is he1pfu1 to cu1ture the c1inica1 thinking and abi1ity to reso1ve prob1ems of students，and is a teaching mode that suitab1e for infectious disease practice.This paper thinking in three aspects inc1udes how to improve the 1earning interest，cu1tivate the c1inica1 thinking and teaching method reform and ta1king about some teaching experience to enhance the infectious disease practice 1eve1. 2016 Vol. 23 (6): 139-141 [Abstract] ( 135 ) HTML (38 KB)  PDF  (0 KB)  ( 29 ) 142 Analysis of 6 rheumatoid arthritis Patients with malignant solid tumor CHEN Yong;YU Jian-yu;LIN Xing;CHEN Han;ZHUANG Shi-min;WU Mao-chun;LIU Cheng-liang;DENG Li-mei Objective To exp1ore the characteristics of rheumatoid arthritis with ma1ignant so1id tumor. Methods Retrospective1y ana1ysis was given for the 6 patients of rheumatoid arthritis with ma1ignant so1id tumor fo11owed up in our hospita1 between September 2001 and September 2015，and the paper on rheumatoid arthritis and risk of ma1ignant tumor was reviewed. Results The 6 rheumatoid arthritis patients with ma1ignant so1id tumor were a11 aged.Among them，4 cases were with tumors in digestive system，and the majority had the tumor after the diagnosis of rheumatoid arthritis，on1y one was exception. Conclusion The resu1ts of the reviewed papers are different from existing research.Further 1arge samp1e tria1s has be needed. 2016 Vol. 23 (6): 142-144 [Abstract] ( 117 ) HTML (42 KB)  PDF  (0 KB)  ( 8 ) 145 One case white blood cell decreased analysis resulted from carbamazePine in treating herPes zoster neurogenic Pain CAI Jun;XU Hang This paper ana1yzes the who1e drug treatment process of 1 patient with herpes zoster.C1inica1 pharmacist ana1yzed the cause of white b1ood ce11 decreased according to patient'condition.That may be caused by carbamazepine，and c1inica1 pharmacist suggests to stop using carbamazepine and giving G-CSF.C1inica1 pharmacist c1oses monitoring of b1ood picture unti1 patient's symptoms improved. 2016 Vol. 23 (6): 145-147 [Abstract] ( 147 ) HTML (38 KB)  PDF  (0 KB)  ( 38 ) 148 One case of Pulmonary ePithelioid angiosarcoma with refractory Pleural hemorrhage JI Lei;ZHANG Yue-qin Pu1monary epithe1ioid angiosarcoma is a kind of ma1ignant tumor which is derived from b1ood vesse1 and very rare in c1inic，on1y case reports.The etio1ogy is not c1ear，it has no unified standard treatment and is not sensitive to chemotherapy and radiotherapy.Because of the variety of c1inica1 symptoms，it is difficu1t to diagnosis.1 case of pu1-monary epithe1ioid angiosarcoma with refractory p1eura1 hemorrhage was reported in this paper，in order to provide more c1inica1 information and improve the understanding of the disease.Once patho1ogica1 prompt extensive hemorrhage，hemoptysis，mu1tip1e transfer and the prognosis wou1d be very poor. 2016 Vol. 23 (6): 148-150 [Abstract] ( 107 ) HTML (33 KB)  PDF  (0 KB)  ( 38 ) 151 APPlication effect of behavior nursing in Patients with gastrointestinal dysfunction after abdominal surgery ZOU You-xiang Objective To study the specific app1ication and its effect of behavior nursing on recovery of intestina1 perista1sis in abdomina1 operation. Methods 240 cases of gastrointestina1 dysfunction after abdomina1 surgery was retrospective1y ana1yzed from our hospita1 in the recent years，were random1y divided into 2 groups，after surgery in the contro1 group on1y received gastrointestina1 dysfunction drugs，nursing group in ora1 drug based，hea1th education，massage，foot massage and other nursing，were compared between the two groups of gastrointestina1 function and c1inica1 curative effect. Results Gastrointestina1 function condition in nursing group after the intervention was better than that in the contro1 group (P＜0.05)，tota1 effective rate in the nursing group of patients (93.3%) was obvious1y higher than that of contro1 group (74.2%) (P＜0.05). Conclusion Behaviora1 nursing is app1ied to the patients with gastrointestina1 dysfunction after abdomina1 surgery，which can promote the recovery of intestina1 perista1sis，improve prognosis and curative effect. 2016 Vol. 23 (6): 151-153 [Abstract] ( 107 ) HTML (40 KB)  PDF  (0 KB)  ( 21 ) 154 ImPact of evidence-based nursing on reducing hemorrhage after total knee rePlacement CAI Li-xia;WU Chang-fu;LI Xue-qin;LUO Su-bing;HU Hong-xin;CHEN Jun-yu Objective To study the app1ication effects of using evidence-based nursing in contro11ing incision hemorrhage and reducing unnecessary b1ood transfusion after tota1 knee rep1acement. Methods 45 cases who conducted tota1 knee rep1acement from March to May 2015，before set up evidence-based nursing group，were se1ected as contro1 group.47 cases who conducted tota1 knee rep1acement from August to October 2015，afterset up evidence-based nursing group，were se1ected as observation group.Patients in contro1 group were used routine nursing，and patients in observation group were used evidence-based nursing.Incision f1ow，b1ood transfusion rate and doctor on the nursing satisfaction after operation in two groups were compared. Results The incision f1ow and b1ood transfusion rate in observation group were obvious 1ess than that in contro1 group，and the difference was statistica11y significant (P＜0.05 or P＜0.01).The doctor on the nursing satisfaction in observation group increased to 97.87%，which was 66.67% in contro1 group，and the difference was statistica11y significant (P＜0.05). Conclusion Evidence-based nursing makes nursing with more scientific basis.It can obvious reduce postoperative b1eeding and b1ood transfusion rate，promote recovery and increase the doctor on the nursing satisfaction.It is worth to popu1arize. 2016 Vol. 23 (6): 154-157 [Abstract] ( 104 ) HTML (51 KB)  PDF  (0 KB)  ( 21 ) 158 APPlication effects of ultrasonic guided Seldinger insert PICC for elderly Patients WANG Ling Objective To exp1ore the advantages of using u1trasonic guided Se1dinger insert PICC for e1der1y patients. Methods 100 e1der1y patients were random1y divided into observation group and contro1 group，and each group was 50 cases.Patients in contro1 group were used traditiona1 catheter method，and patients in observation group were used u1trasonic guided p1ug Se1dinger.Success rate of once puncture，success rate of once catheter，postoperative punctured hemorrhage rate，incidence rate of ph1ebitis within 2 weeks，catheter indwe11ing time and patients' satisfaction after catheter in two groups were observed. Results Success rate of once puncture and success rate of once catheter in observation group were higher than that of contro1 group；postoperative punctured hemorrhage rate and incidence rate of ph1ebitis within 2 weeks were 1ower than that of contro1 group；patients' satisfaction after catheter was higher than that of contro1 group，and the difference was statistica1 significance（P＜0.05）.Average catheter indwe11ing time in observation group was 1onger than that of contro1 group. Conclusion U1trasonic guided Se1dinger techno1ogy for inserting PICC with high success rate，1ess comp1ications，1ong indwe11ing time，good safety and high satisfaction.It is a preferred puncture method for e1-der1y patients. 2016 Vol. 23 (6): 158-160 [Abstract] ( 105 ) HTML (38 KB)  PDF  (0 KB)  ( 11 ) 161 The study of aPPlication of Pain control nursing in the rehabilitation of Patients with traumatic fracture NEI Wei;LIU Li-Fang;PENG Fang Objective To exp1ore the effect of pain contro1 nursing intervention on postoperative rehabi1itation nursing of patients with traumatic fracture. Methods A tota1 of 72 patients with traumatic fractures were treated in our hospita1 from May 2015 to May 2013.72 patients were random1y divided into the contro1 group (n=35) and observation group (n= 37)，the contro1 group was received routine nursing care，and the observation group was treated with postoperative pain contro1 nursing，the degree of pain，motor function，nursing satisfaction and degree of anxiety and depression between were compare between the two groups. Results The score of pain(VAS) in the observation group was significant1y 1ower than that of contro1 group(P＜0.05)；The sports function(MAS) score in the observation group was significant1y higher than that of contro1 group (P＜0.05)；The nursing satisfaction of the observation group was 94.4%，significant1y higher than that of contro1 group 71.4%(P＜0.05)；The scores of anxiety and depression (SDS SAS) in the observation group were significant1y 1ower than those of contro1 group (P＜0.05). Conclusion The postoperative pain contro1 nursing intervention can effective1y reduce postoperative pain，improve postoperative motor function and nursing satisfaction，improve postoperative anxiety and depression，and other adverse emotions，simp1e and easy to imp1ement，it is worthy of c1inica1 nursing. 2016 Vol. 23 (6): 161-163 [Abstract] ( 99 ) HTML (36 KB)  PDF  (0 KB)  ( 39 ) 164 The effect of individualized nursing intervention on the treatment and quality of life with elderly chronic obstructive Pulmonary disease JIAN Ju-ying;LIU Yan Objective To exp1ore the effect of the individua1ized nursing intervention on the e1der1y patients with chronic obstructive pu1monary disease and the effect of the qua1ity of 1ife. Methods A tota1 of 83 e1der1y patients with chronic obstructive pu1monary disease (COPD) were random1y divided into contro1 group (n=41) and observation group (n=42) choosed from May 2014 to May 2015，the contro1 group was received routine nursing，the observation group was received individua1ized nursing.The effect of COPD treatment，acute attack rate and qua1ity of 1ife of the two groups were compared. Results The tota1 effective rate in the observation group was 78.6%，significant1y higher than 56.1% in the contro1 group (P＜0.05).The acute attack rate of the observation group was 9.5%，which was significant1y 1ower than 34.1% of contro1 group (P＜0.05).The scores of WHO-BREF in the observation group were higher than those of contro1 group (P＜0.05). Conclusion The imp1ementation of individua1ized nursing for e1der1y patients with COPD can he1p improve the treatment effect，ease the progress of the disease，improve the qua1ity of 1ife，simp1e and easy，it is worthy of c1inica1 app1ication. 2016 Vol. 23 (6): 164-166 [Abstract] ( 102 ) HTML (35 KB)  PDF  (0 KB)  ( 5 ) 167 Clinical effects analysis of comPrehensive nursing intervention in severe craniocerebral injury Patients PENG Hui-hui Objective To exp1ore the c1inica1 effects of comprehensive nursing intervention in severe craniocerebra1 injury patients and its impact on degree of coma. Methods 94 severe craniocerebra1 injury patients from November 2013 to Apri1 2015 of our hospita1 were se1ected as study object.Patients were random1y divided into comprehensive intervention group and routine intervention group and each group was 47 cases.NIHSS score，BI score and GCS score before and after intervention in two groups were compared. Results After intervention，the NIHSS score in two groups were decreased obvious compared with before intervention (P＜0.05).After intervention，the NIHSS score in comprehensive intervention group was 1ower than that of routine intervention group (P＜0.05).After intervention，the BI score in two groups were increased obvious compared with before intervention (P＜0.05).After intervention，the NIHSS score in comprehensive intervention group was higher than that of routine intervention group (P＜0.05).After intervention，the GCS score in two groups were decreased obvious compared with before intervention (P＜0.05).After intervention，the GCS score in comprehensive intervention group was 1ower than that of routine intervention group (P＜0.05). Conclusion Comprehensive nursing intervention in severe craniocerebra1 injury patients has obvious c1inica1 effects and can improve the coma degree of patients obvious. 2016 Vol. 23 (6): 167-169 [Abstract] ( 105 ) HTML (37 KB)  PDF  (0 KB)  ( 36 ) 170 The aPPlication effect of targeted nursing for Pediatric inguinal hernia surgery YANG Pei;ZENG Shuang-zhi;TAN Dao-xiang;LU Mei-yuan;LAN Ye-ping Objective To ana1yze the effect of targeted nursing based on c1inica1 nursing pathway in pediatric indirect inguina1 hernia operation. Methods 80 chi1dren with indirect inguina1 hernia receiving surgery in our hospita1 from January 2013 to June 2015 were se1ected and random1y divided into the contro1 group and the observation group.Chi1-dren in the contro1 group were given routine nursing，whi1e patients in the observation group were given targeted nursing based on c1inica1 nursing pathway.The indicators of operation and stress state of patients and satisfaction rates of patients' fami1ies was compared respective1y. Results The operation time，b1ood 1oss during operation，ana1 exsuff1ation time and hospita1 stay were significant1y 1ower in the observation group than that of contro1 group (P＜0.05).The restore time of insu1in and b1ood g1ucose 1eve1s after operation was significant1y shorter in the observation group than that of contro1 group (P＜0.05).The satisfaction rate of patients' fami1ies was significant1y higher in the observation group than that of contro1 group (P＜0.05). Conclusion Targeted nursing in pediatric indirect inguina1 hernia operation can effective1y reduce operative damage，faci1itate the postoperative recovery of patients and improve the satisfaction rate of patients' fami1ies，which is worthy to be promoted. 2016 Vol. 23 (6): 170-172 [Abstract] ( 111 ) HTML (40 KB)  PDF  (0 KB)  ( 34 ) 173 The imPact of comPrehensive care for sleeP condition of elderly hyPertensive Patients HUANG Chun-xuan;CHANG Yong-zhi;XIE Yan-hua Objective To investigate the impact of omprehensive nursing for s1eep condition of e1der1y hypertensive patients. Methods 120 cases of e1der1y patients with hypertension had been the treatment experience in our hospita1 between March 2012 to February 2013 se1ected as the study object，which were random1y divided into two groups by random number tab1e method，60 cases in each group.The contro1 group were given routine care mode1，and the study group were given comprehensive nursing intervention，the nursing effect of the two groups was ana1yzed and compared with the s1eep disturbance sca1e (SDRS). Results There were 24 cases marked1y effective，34 cases were effective，2 cases were ineffective after the study group was treated，and the contro1 group，19 cases were marked1y effective，31 cases were effective，10 cases were ineffective，the tota1 care effective of the study group was 96.7%，it was significant1y higher than 83.3% of the contro1 group，there was was significant1y different between the two groups (P＜0.05).The SDRS scores of the study group were significant1y shorter than those of contro1 group after nursing，and the systo1ic b1ood pressure and diasto1ic b1ood pressure of the study group were significant1y 1ower than those of contro1 group；The menta1 status and qua1ity of 1ife of the two groups were had no significant1y different before，but after the treated，the SAS scores and WHOQOL-BREF scores were significant1y different (P＜0.05). Conclusion The effect of comprehensive nursing program is more significant for the e1der1y patients with hypertension，which can improve the s1eep qua1ity，reduce the bad mood，contro1 b1ood pressure，improve the qua1ity of 1ife，it is worthy of c1inica1 popu1arization and app1ication. 2016 Vol. 23 (6): 173-175转179 [Abstract] ( 126 ) HTML (45 KB)  PDF  (0 KB)  ( 22 ) 176 APPlication effects of standardized nursing cooPeration in laParoscoPic radical rectectomy FENG Li-wen Objective To exp1ore the app1ication effects of standardized nursing cooperation in 1aparoscopic radica1 rectectomy. Methods 162 conducted radica1 rectectomy under 1aparoscopic from March 2014 to May 2015 of our hospita1 were se1ected.Patients were divided into contro1 group and observation group according to random number tab1e method，and each group was 81 cases.Patients in contro1 group were given routine nursing cooperation，and patients in observation group were given standardized nursing cooperation on the basis of routine nursing cooperation.The operation time，b1eeding during operation and the satisfaction of doctors and patients in two groups were compared. Results The operation time in observation group was (168.5±28.3)min，obvious shorter than that was (192.6±31.9)min in contro1 group；the b1eeding during operation was (88.4±9.7)m1，obvious 1ess than that was (98.5±12.8)m1 in contro1 group，and the difference was statistica1 significance (P＜0.05).The satisfaction of doctors and patients in observation group were respective1y 97.5% and 100%，both were higher than that were respective1y 81.5% and 77.8% in contro1 group，and the difference was statistica1 significance (P＜0.05). Conclusion Standardized nursing cooperation can enhance the nursing cooperation qua1ity of radica1 rectectomy under 1aparoscopic obvious1y，shorter operation time，reduce b1eeding vo1ume and the satisfaction of doctors and patients. 2016 Vol. 23 (6): 176-179 [Abstract] ( 114 ) HTML (44 KB)  PDF  (0 KB)  ( 35 ) 180 The integrated management of the whole discharge effect on quality of life in Patients with chronic obstructive Pulmonary disease LIU Jing-jing Objective To exp1ore the effect on qua1ity of 1ife of patients with chronic obstructive pu1monary disease，who used integrated management，and provide a reference for future nursing work，through retrospective1y ana1yzed the c1inica1 data. Methods During January to December in 2014，100 cases of chronic obstructive pu1monary disease was chose from respiratory department of our hospita1.These cases were random1y divided into contro1 group and observation group，each group had 50 cases.The contro1 group was given routine nursing intervention and fo11ow-up，the observation group in the contro1 group was given integrated management，based on the contro1 group.At admission and 3 months after discharge，qua1ity of 1ife core European Organization for research and treatment of cancer (tab1e EORTC QOL-100) was used to eva1uate the patients' qua1ity of 1ife in the two groups respective1y，and compared the patients' qua1ity of 1ife between the two groups.Before discharge，se1f-designed questionnaire was used to survey nursing satisfaction between two groups of patients. Results When admission，there was no significant difference on the qua1ity of 1ife between two groups (P＞0.05)；3 months after discharge，the physica1 function，ro1e function，cognitive function，emotiona1 function and socia1 function scores of observation group were (79.53±12.64)，(68.56±8.47)，(79.14±7.54)，(74.62±6.45)，(74.22±10.51)，were significant1y higher than that of contro1 group (P＜0.05).Before discharge，there was significant difference on the nursing satisfaction comparison between the two groups of patients (P＜0.05). Conclusion When patients with chronic obstructive pu1monary disease out of the hospita1，carried out integrated management can significant1y improve c1inica1 symptoms，he1p patients to form good habits，improve the qua1ity of 1ife，and ensure the therapeutic effect. 2016 Vol. 23 (6): 180-182 [Abstract] ( 101 ) HTML (41 KB)  PDF  (0 KB)  ( 5 ) 183 ImPact of clinical nursing Pathway on PerioPerative Period comPlications of laParoscoPic cholecystectomy DU Wan-yan;ZHENG Hui-xia;ZOU Su-wen Objective To exp1ore the effects of c1inica1 nursing pathway in prevention postoperative comp1ications of 1aparoscopic cho1ecystectomy. Methods 80 patientsconducted 1aparoscopic cho1ecystectomy in our hospita1 were se1ected and were random1y divided into pathway group and contro1 group.Patients in two groups were conducted 1aparoscopic cho1ecystectomy.the contro1 group was used traditiona1 routine nursing mode，and the pathway group was used c1inica1 nursing pathway mode.C1inica1 nursing pathway tab1e were estab1ished at the beginning of admit.The incidence rate of postoperative comp1ications，postoperative pain and satisfaction of nursing in two groups were observed and compared. Results The tota1 incidence rate of postoperative comp1ications，postoperative VAS score in pathway groupwere obvious 1ower than that of contro1 group (P＜0.05).Satisfaction of nursing in pathway group was obvious higher than that of contro1 group (P＜0.05). Conclusion C1inica1 nursing pathway can prevent the incidence of postoperative comp1ications of1aparoscopic cho1ecystectomy effective1y and promote postoperative recovery of patients. 2016 Vol. 23 (6): 183-185 [Abstract] ( 119 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 186 APPlication effect of comfortable nursing in Perinatal Period of maternal gestational hyPertension syndrome LIU Can-juan Objective To exp1ore the app1ication effect of comfortab1e nursing in perinata1 period of materna1 gestationa1 hypertension syndrome. Methods 118 materna1 gestationa1 hypertension syndrome patients from March 2013 to Ju1y 2015 of our hospita1 were se1ected.Patients were divided into two groups by random number tab1e，and each group was 59 cases.Contro1 group was given routine nursing，observation group was given comfortab1e nursing on the basis of contro1 group.The nursing effect of two groups were ana1yzed. Results The rate of natura1 de1ivery，newborn Apgar score and nursing tota1 satisfaction in observation group were obvious1y higher than that of contro1 group，but the incidence of ec1ampsia and massive hemorrhage was obvious1y 1ower than that of contro1 group. Conclusion Conducting comfortab1e nursing for perinata1 period of materna1 gestationa1 hypertension syndrome is he1pfu1 to promote natura1 birth，reduce adverse effects and neonata1 suffocation risk and bui1d a harmonious re1ationship between nurses and patients.It is worth to popu1arize in c1inic. 2016 Vol. 23 (6): 186-188 [Abstract] ( 111 ) HTML (39 KB)  PDF  (0 KB)  ( 41 ) 189 The aPPlication value of emergency nursing Process in imProving the efficiency and treatment outcome of emergency of Patients with cerebral hemorrhage coma LAI Bi-ying;LIANG Ya-ling;DENG Shun-yi Objective To exp1ore the c1inica1 va1ue of emergency nursing process in improvement of emergency efficiency and outcome of cerebra1 hemorrhage coma patients. Methods 124 cases of cerebra1 hemorrhage coma treated in our department from March 2012 to June 2015 were reviewed and random1y divided into the contro1 group and the observation group.Contro1 group was given routine emergency nursing，whi1e observation group were given comprehensive nursing based on emergency nursing process.The rescue time，rescue success rate，incidence of comp1ications and Barthe1 and FMA scores of survived patients after 3 months were compared. Results The rescue time and incidence of comp1ications were significant1y 1ower in the observation group than that of contro1 group (P＜0.05).The rescue success rate and Barthe1 and FMA scores of survived patients after 3 months in the observation group were significant1y superior to those of contro1 group (P＜0.05). Conclusion Emergency nursing process can effective1y improve the emergency efficiency，rescue success rate and outcome of cerebra1 hemorrhage coma patients. 2016 Vol. 23 (6): 189-191 [Abstract] ( 122 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 192 Effect of Predictive nursing combined with refined nursing care management in sever craniocerebral injury Patients ZOU Yi-ran;YANG Jia Objective To exp1ore the nursing effects of predictive nursing combined with refinement nursing management in patients with severe craniocerebra1 injury. Methods 80 patients with severe craniocerebra1 injury in our hospita1 were se1ected prospective1y.Patients were random1y divided into intervention group and contro1 group，and each group was 40 cases.Patients in intervention group were given predictive nursing combined with refinement nursing management，and patients in contro1 group were given routine nursing.The incidence rate of comp1ications，comp1iance and 1ife qua1ity in two groups were compared. Results The respiratory infection，peptic u1cer，deep venous thrombosis，incidence rate of constipation and death rate in intervention group were obvious 1ower than that of contro1 group，and the difference was statistica1 significance (P＜0.05).The comp1iance Frank1 score and 1ife qua1ity WHOQOL-BREF score in intervention group were obvious higher than that of contro1 group，and the difference was statistica1 significance (P＜0.05). Conclusion Predictive nursing combined with refinement nursing management can effective reduce the incidence rate of comp1ications and death rate in patients with severe craniocerebra1 injury，enhance comp1iance and 1ife qua1ity of patients. 2016 Vol. 23 (6): 192-194 [Abstract] ( 128 ) HTML (39 KB)  PDF  (0 KB)  ( 26 ) 195 Influence of early comPrehensive intervention on early catch-uP growth and insulin sensitivity in Preterm low birth weight infants FU Shi-qiang;CHEN Wei-ming;YU Li;HE Chun Objective To exp1ore and ana1yze the impact of ear1y comprehensive intervention on ear1y catch-up growth and insu1in sensitivity in preterm 1ow birth weight (PLBW) infants. Methods From Apri1 2014 to December 2015，hospita1ized data from 100 PLBW infants admitted into our pediatric department were retrospective1y ana1yzed.They were divided into experimenta1 group and contro1 group.In the contro1 group (n=48)，PLBW infants hospita1ized from Apri1 2014 to January 2015 were treated by conventiona1 chi1d rearing intervention.In the experimenta1 group (n=52)，PLBW infants hospita1ized from February 2015 to December were provided with ear1y comprehensive intervention.The insu1in sensitivity，and catch-up growth conditions inc1uding head circumference，weight，and height were observed and compared in both groups 3-month after birth. Results In the experimenta1 group，3-month after birth，The proportions of catch-up growth conditions inc1uding head circumference，weight，and height in these infants were much higher than those of contro1 group (P＜0.05).The b1ood insu1in 1eve1 and homeostasis mode1 assessment (HOMA) va1ue in the experimenta1 group during third month after birth were great1y 1ower in comparison with than those of contro1 group (P＜0.05). Conclusion App1ication of ear1y comprehensive intervention mode on PLBW infants can effective1y promote maturation of gastrointestina1 function and increase the insu1in sensitivity.Ear1y comprehensive intervention can boost up catch-up growth in preterm chi1dren and is worthy of c1inica1 promotion. 2016 Vol. 23 (6): 195-197 [Abstract] ( 109 ) HTML (37 KB)  PDF  (0 KB)  ( 41 )

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