噻托溴铵联合沙美特罗替卡松治疗中重度慢性阻塞性肺疾病的临床效果

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Abstract Objective To exp1ore the c1inica1 effect of tiotropium bromide combined with sa1metero1 and f1uticas in the treatment of moderate-severe moderate-severe chronic obstructive pu1monary disease (COPD). Methods 60 cases of moderate-severe COPD in our hospita1 from January 2014 to January 2015 were se1ected and divided into the observation group and the contro1 group according to the different drug therapy，30 cases in each group.A11 patients were given conventiona1 symptomatic supportive treatment.The contro1 group was given sa1metero1 and f1uticas powder inha1ant，the observation group was given tiotropium bromide powder inha1ant on the basis of the contro1 group.The two groups were a11 given 12 weeks treatment.The 1eve1 of FEV1，FVC，FEV1/FVC，FEV1%，PaO2，PaCO2before and after treatment and the c1inica1 effect of the two groups was compared. Results The 1eve1 of FEV1，FVC，FEV1/FVC，FEV1% after treatment in the observation group was higher than that in the contro1 group after treatment，with significant difference (P＜0.05).The 1eve1 of PaO2after treatment in the observation group was higher than that in the contro1 group after treatment，the 1eve1 of PaCO2after treatment in the observation group was 1ower than that in the contro1 group after treatment，with significant difference (P＜0.05).The tota1 effective rate in the observation group was 100.0%，which was higher than 90.0% in the contro1 group，with significant difference (P＜0.05). Conclusion Tiotropium bromide combined with sa1metero1 and f1uticas treatment can improve 1ung function and oxygen supp1y of COPD patients，it is worthy of c1inica1 promotion and app1ication.

Key words： Chronic obstructive pu1monary disease Tiotropium bromide Sa1metero1 and f1uticas

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	MU Zhao-hong
	LI Xiao-juan
	JIA Gang

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MU Zhao-hong,LI Xiao-juan,JIA Gang. Clinical effect of tiotroPium bromide combined with salmeterol and fluticas in the treatment of moderate-severe chronic obstructive Pulmonary disease[J]. 中国当代医药, 2016, 23(6): 87-89转92.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I6/87

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