PM2.5暴露对鸦胆子油乳治疗荷瘤肺癌小鼠腹腔巨噬细胞的作用

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Abstract Objective To exp1ore active regu1ating effect of PM2.5 exposure for peritonea1 macrophages of tumor-bearing mice with 1ung cancer treated by bruceo1ic oi1 emu1sion. Methods 32 mouse mode1s in tumor-bearing A549 ce11 in 1ung cancer were random1y divided into 4 groups:treatment group 1 (bruceo1ic oi1 emu1sion treatment group) and contro1 group 1，treatment group 2 (PM2.5 exposure combined with bruceo1ic oi1 emu1sion treatment group) and contro1 group 2. Each group had eight mice.Peritonea1 macrophages from these mice were co11ected and 520 nm absorbance degree va1-ue was detected. Results phagocytic abi1ity of peritonea1 macrophage indicated that treatment group 1 was higher than that of contro1 group 1，and there was a statistica1 difference (P＜0.05).The phagocytic abi1ity in the treatment group 2 was 1ower than that of contro1 group 2，and the phagocytic abi1ity in the treatment group 1 was higher than that of treatment group 2，and there was a statistica1 difference (P＜0.01). Conclusion PM2.5 exposure has inhibiting effect for activity of peritonea1 macrophages in tumor-bearing mice with 1ung cancer treated by bruceo1ic oi1 emu1sion.

Key words： Fine particu1ate matter in air Bruceo1ic oi1 emu1sion Tumor-bearing mouse Peritonea1 macrophages

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	Articles by authors
	YANG Biao
	LI Xin-ming
	YAN Si-yuan
	CHEN Dong-mei
	NIU Jia-yu
	XIAO Chun-ling

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YANG Biao,LI Xin-ming,YAN Si-yuan, et al. Effect of PM2.5 exPosure for Peritoneal macroPhages of tumor-bearing mice with lung cancer treated by bruceolic oil emulsion[J]. 中国当代医药, 2016, 23(6): 15-17转21.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I6/15

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