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2020 Vol. 27, No. 17
Published: 2020-06-18
4
Influence of anticancer alkylating agent 3-Bromopyruvate on aging indexes and lifespan of Caenorhabditis elegans
WEI Qian-nan; WANG Su-juan; LIU Jia-qi; BU Xiao-bo; LI Dong-hang
Objective
To explores the influence of different concentrations of 3-Bromopyruvate (3-BrPA)on the lifespan of Caenorhabditis elegans and tests of related aging indicators to systematically assess its impact on life conditions.
Methods
The same period of Caenorhabditis elegans was selected as the experimental object,3-BrPA of 3.125,6.250,12.500 and 25.000 mmol/L were selected as the experimental group,and 0.000 mmol/L were selected as the control group.A total of 135cases of Caenorhabditis elegans were selected for each concentration in the nematode life test group,and the survival curves of the each experimental group and the control group were recorded and plotted in the nematode swallowing capacity experiment,10 cases of Caenorhabditis elegans were selected in the each group,and the swallowing rate graph reflecting the aging degree of the Caenorhabditis elegans was recorded and plotted.
Results
Both Caenorhabditis elegans lifespan test and pharynx pumping ability test results showed that which in the experimental group of 3-BrPA of 3.125,25.000mmol/L were lower than those of the control group,and the differenceswere statistically significant(P＜0.05).There were no significant differences in the Caenorhabditis elegans lifespan test and pharynx pumping ability test results between the the experimental group of 3-BrPA of 6.250,12.500 mmol/L and the control group(P＞0.05).
Conclusion
3-BrPA at 3.125and 25.000mmol/L showed a certain degree of damage to Caenorhabditis elegans;However,3-BrPA at the concentrations of 6.250 and 12.500mmol/L aren′t show significant toxic and side effect on Caenorhabditis elegans,and compared with the control group,the lifespan of the Caenorhabditis elegans is not shortened and prolonged.The occurrence of this special phenomenon may be related to the pyruvate concentration in the body of Caenorhabditis elegans and themechanism of dietary restriction (DR).The specific reasons are still being further studied.
2020 Vol. 27 (17): 4-7 [
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Influence of early use of different courses of antibiotic on the gutm icrobiota of 28-day-old preterm infants
WANG Jun-ping; WANG Yan-li; ZHONG Jun-juan; YAN Hui-heng; ZHANG Yong; CHEN Yun-bin
Objective
To explore the influence of early empirical application of different treatment courses of antibiotic on the gutmicrobiota of28-day-old preterm infants through 16S rRNA sequencing technology.
Methods
From December 2017 to May 2018,a total of 27 cases of hospitalized preterm infants in GuangdongWomen and Children Hospitalwere enrolled,among them,penicillin+the third generation cephalosporin≤3dayswere selected as the short course group(the G1group,9 cases),penicillin+the third generation cephalosporin≥7 dayswere selected as the long course group(the G2group,18 cases).The fecal samplesatpostnatal28 dayswere collected,and 16S rRNA sequencing technology was used to analyze the changes ofmicrobial community diversity.
Results
In the structural composition of the flora,the main phylum included Actinobacteria,Bacteroidetes,Firmicutes,and Proteobacteria,among which pachytene was the most abundant,the thick-walled mycoplasma was the most abundant.There were no significant differences in the Bacteroidetes and Proteobacteria between the G1group(0.03%,34.11%)and the G2group(0.04%,14.23%)(P＞0.05).There was no statistical difference in the alpha diversity between the G1group and the G2group (P＞0.05).Betaproteobacteria(LDA=6.43,P=0.017),Comomamonadaceae(LDA=6.24,P=0.017),Dermabacteraceae(LDA=6.60,P=0.016),Luteibacter(LDA=6.06,P=0.026)and Veillonella (LDA=7.51,P=0.049)in the G1group were higher than those in the G2group,there were statistical differences (P＜0.05).
Conclusion
Early empirical and long-term application of broad-spectrum antibiotic may lead to the colonization of normal intestinal flora and the delay of the advantage of time in preterm infants.
2020 Vol. 27 (17): 8-11 [
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Analysis of risk factors for essential hypertension complicated with cerebral infarction
LI Qi-guang； CHEN Pei-song； LIANG Ya-ru； ZHONG Guo-quan
Objective
To explore the risk factors of the occurrence of essential hypertension complicated with cerebral infarction.
Methods
A total of 377 hospitalized patientswith primary diagnosis of essential hypertension who were admitted to the Department of Neurology in the First Affiliated Hospital of Sun Yat-sen University from January 2016to July 2018 were selected in the study.They were divided into hypertensive complicated cerebral infarction group(114cases)and simple hypertensive group (263cases)according to whether they were complicated with cerebral infarction.Another 109 caseswith normal physical examination during the same period were selected as the healthy control group.Univariate analysis was used to analyze general clinical data such as systolic blood pressure,diastolic blood pressure,and coronary heart disease proportion of all researchers aswell as urea nitrogen(BUN),alkaline phosphatase(ALP),homocysteine(Hcy),white blood cell count(WBC),platelet count(PLT),fibrinogen(Fbg),high-sensitivity C-reactive protein(hs-CRP)and D-dimer(D-D)and other laboratory indicators for evaluation.Bymultivariate analysis,the risk factors for hypertension complicated with cerebral infarction were determined.
Results
Univariate analysis showed that systolic blood pressure,diastolic blood pressure,the proportion of coronary heart disease,and the levels of BUN,ALP,Hcy,WBC,Fbg,hs-CRP and D-D in the hypertensive complicated cerebral infarction group were higher than those in the simple hypertension group and healthy control group,while the level of PLT was lower than that in the simple hypertension group and healthy control group,the differenceswere statistically significant(P＜0.05).Multivariate analysis results showed that ALP(β=0.61,OR=1.88,95%CI:1.38-2.61),Hcy(β=0.37,OR=1.62,95%CI:1.17-2.25),Fbg(β=0.53,OR=1.85,95%CI:1.35-2.52)were risk factors for hypertension complicated with cerebral infarction (P＜0.05).
Conclusion
ALP,Hcy and Fbg are the risk factors for hypertension complicated with cerebral infarction,which are important for clinical evaluation of cerebral infarction.
2020 Vol. 27 (17): 12-15转20 [
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16
Analysis of influencing factors of hemorrhage transformation in acute ischem ic stroke patients without thrombolytic therapy
LIU Ming-su； TANG Ye； FU Qing； LI Guang-qin
Objective
To analyze the influencing factors of hemorrhage transformation in acute ischemic stroke patients without thrombolytic therapy.
Methods
Retrospective analysiswas performed in the clinical data of 802acute ischemic stroke patientswithout thrombolytic therapy from January 2017 to December 2018 in our hospital,and they were divided into hemorrhage transformation group(35cases)and non-hemorrhage transformation group(767 cases)according to whether hemorrhage transformation occurred or not.The related factors of the two groupswere compared,and the factorswith statistical differenceswere further included in themultivariate Logistic regression analysis.
Results
Univariate analysis results showed that there were statistically significant differences in age,history of hypertension,atrial fibrillation,coronary heart disease,heart disease,stroke type,large-area ischemic stroke,national institutes of health stroke scale(NIHSS)score,antiplatelet drugs,and albumin level between the two groups(P＜0.05).Multivariate Logistic regression analysis showed thathigh NIHSSscore,large-area ischemic stroke and low albumin levelwere independent risk factors for hemorrhagic transformation,and history ofhypertension was an independent protective factor for hemorrhagic transformation(P＜0.05).
Conclusion
Low albumin level,high NIHSS score,large-area ischemic stroke are independently risk factors for hemorrhagic transformation of acute ischemic stroke patients without thrombolytic therapy and hypertension is an independently protective factor,which has provided great help in clinical decision-making,but large sample of innovative researches are still needed to further confirm this conclusion.
2020 Vol. 27 (17): 16-20 [
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Role of chitinase 3-like protein 1 in cancer development and its application value
CHEN Yu； XIONG Juan
Chitinase-3-like protein 1(CHI3L1)is a chitinase like proteins(CLPs)without chitinase activity.In recent years,international researches on the relationship between CHI3L1and cancer have gradually increased.CHI3L1plays an important role in immune response,inflammation,and extracellular matrix composition,which can affect tumor growth,metastasis,and response to treatment by regulating the tumormicroenvironment.Some researchers have recommended CHI3L1as a new tumormarker for predicting the occurrence,development and prognosis of tumors.At present,people′s understanding of CHI3L1and its relationship with cancer is not enough.This paper collects and summarizes the internationally advanced research results on CHI3L1and cancer in recent years,from the aspects of the mechanism of CHI3L1in cancer development,expression in human cancer,related signaling pathways in cancer development and research value in cancer treatment,so as to explain the role and application value of CHI3L1in the development of cancer.
2020 Vol. 27 (17): 21-24 [
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25
Overview of adverse reactions of pharmaceutical excipients
ZHAO Li-hua; YING Yu-jie
Pharmaceutical excipients are important components of pharmaceutical preparations.The pharmaceutical excipients as well as active pharmaceutical ingredients are involved in the whole process of absorption,distribution,metabolism and excretion in vivo.Therefore,the safety of pharmaceutical excipients is closely related to the that of the pharmaceutical preparations.Pharmaceutical excipients are considered to be inert in contrast to active ingredients.At present,many literature reports have shown that quite a few excipients can cause adverse reactions.Although the incidence is low,it can affect the normal function ofmany organs and systems of the human body,such as breathing,blood,digestion and other systems.Therefore,clinicians and drug and nursing personnel should be aware of the adverse reactions related to pharmaceutical excipients,and the drug regulatory department should also strengthen the safety managementmeasures of excipients to ensure patients′safemedication.
2020 Vol. 27 (17): 25-28 [
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99
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Research progress on application of thrombelastogram in coagulation function test
XU Ya-min； LIN Zheng-ming； CHEN Ling
Platelet aggregation is an important physiological characteristic of platelets involved in hemostasis and thrombosis.The determination of platelet aggregation function is of great significance for the clinical diagnosis of prethrombotic state,thrombotic diseases and monitoring of antiplatelet drugs.The thrombelastogram test uses only a small amount of whole blood of the patient,and can dynamicallymonitor the entire coagulation process.The detection principle is different from the traditional coagulation function test，which is a detection method that can evaluate the dynamic process of coagulation and fibrinolysis as a whole.It can comprehensively evaluate the factors such as the formation speed,dissolution state,firmness,stability,elasticity and coagulation factors (fibrinogen,platelet counts and function)of fibrin clot.At present，thrombelastogram has been widely used in clinical practice.This paper reviews the research progress on the application of thrombelastogram in coagulation function test.
2020 Vol. 27 (17): 29-31转39 [
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Effect com parison of retroperitoneal laparoscopic surgery and open operation in the treatmem t of ureteropelvic junction obstruction
YAN Bing； SUN Yi-hai； HUANG Heng-qian； DENG Hong-hui； XIE Guang-yu； FU Jie-xin
Objective
To compare the efficacies of retroperitoneal laparoscopic surgery and open operation in the treatment of ureteropelvic junction obstruction (UPJO),and to discuss the problems that should be paid attention to in retroperitoneal laparoscopic surgery.
Methods
A total of 106patients with unilateral UPJO from January 2014to June 2019 were selected as the study object,they were divided into the observation group (53cases)and the control group(53cases)according to the method of random drawing.The observation group underwent retroperitoneal laparoscopic pyeloplasty,the control group underwent open pyeloplasty.Incision length,operation time,intraoperative bleeding volume,conversion to the open surgery intraoperatively,postoperative recovery time of bowel function,time of postoperative ground activity,length of postoperative hospitalization,postoperative complications,postoperative efficacy were compared between the two groups.
Results
The incision length in the observation group was shorter than that in the control group,the intraoperative bleeding volume in the observation group was less than that in the control group,the postoperative recovery of bowel function,time of postoperative ground activity and length of postoperative hospital stay of the observation group were shorter than those of the control group,there were significant difference (P＜0.01).The differences of operation time,conversion to the open surgery intraoperatively,postoperative complications and postoperative efficacy between two groups were not statistically significant (P＞0.05).
Conclusion
Compared with the open surgery,retroperitoneal laparoscopic pyeloplasty for UPJO has the advantages ofminimally invasive,less bleeding and quick postoperative recovery,it isworthy of clinical promotion and application.
2020 Vol. 27 (17): 32-35 [
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Clinical study of bronchoalveolar lavage combined with pulmonary rehabilitation in the treatment of pneumoconiosis
FU Chun-sheng； DAI Lian-ying； ZHAO Bin
Objective
To explore the clinical effect of bronchoalveolar lavage combined with pulmonary rehabilitation in the treatment of pneumoconiosis.
Methods
A total of 80 cases of pneumoconiosis patients admitted to our hospital from July 2018 to September 2019 were selected as the research objects.The selected patients were divided into the treatmentgroup(40 cases)and the control group(40 cases)according to random number tablemethod.The control group was treated with bronchoalveolar lavage(smallvolume)on thebasisof conventionaldrug treatment,and the treatmentgroup was treated with pulmonary rehabilitation on the basis of the control group.After 2months of treatment,the pulmonary function of the first second forced expiratory volume(FEV
1
),themaximum ventilation volume perminute(MVV),the 6-minute walking test,the Borg scale scores and the St George′s respiratory questionnaire (SGRQ)scores between the two groupswere compared.
Results
Therewere no significant differences in FEV
1
and MVV between the two groups before treatment(P＞0.05).The levels of FEV
1
and MVV of the two groups after treatmentwere higher than those before treatment,the differenceswere statistically significant(P＜0.05).The levels of FEV
1
and MVV in the treatment group after treatmentwere higher than those in the control group,the differenceswere statistically significant(P＜0.05).There were no significant differences between the two groups in the 6-minute walking test and the Borg scale score before treatment(P＞0.05).The 6-minutewalking test of the two groups after treatmentwas longer than that before treatment,and the scores of Borg scale of the two groups after treatmentwere lower than those before treatment,the differences were statistically significant(P＜0.05).The 6-minute walking test of patients in the treatment group after treatmentwas longer than that in the control group,and the score of Borg scale of patients in the treatment group after treatment was lower than that in the control group,the differenceswere statistically significant(P＜0.05).Therewas no significant difference in SGRQ score between the two groups before treatment(P＞0.05).The SGRQ scores of the two groups after treatmentwere lower than those before treatment,the differenceswere statistically significant(P＜0.05).The SGRQ score of the treatment group after treatmentwas lower than that of the control group,the difference was statistically significant(P＜0.05).
Conclusion
Bronchoalveolar lavage combined with pulmonary rehabilitation can significantly improve the respiratory function of patientswith pneumoconiosis,reduce symptoms,improve the ability to exercise,improve the quality of life of patients,which isworthy of clinical promotion and application.
2020 Vol. 27 (17): 36-39 [
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Clinical effect of artificial liver plasma exchange in the treatment of liver failure
LI Qing-qi; GUO Ting; ZHANG Li-li; WANG Wei-xin
Objective
To explore the clinical effect of artificial liver plasma exchange in the treatment of liver failure.
Methods
A total of 88 patients with liver failure who were admitted to the hospital fron March 2013and March 2019 were selected as the subjects.They were divided into group A(44cases)and group B(44cases)by the random number tablemethod.Groups A was given comprehensivemedical treatment,and group B were additionally treated with artificial liver plasma exchange on the basis of group A.The clinical effect,levels of liver function indicators and inflammatory factorswere compared between the two groups.
Results
After 2weeks of treatment,the improvement rate in group B was 75.00%,which was higher than that in group A (40.90%),the difference was statistically significant(P＜0.05).After treatment,the levels of serum aspartate aminotransferase (AST),alanine aminotransferase (ALT),total bilirubin(TBil),and serum interleukin (IL)-17,IL-12,and IL-35in group B were lower than those in group A,the differences were statistically significant(P＜0.05).
Conclusion
The effect of artificial liver plasma exchange is significant in the treatment of liver failure.It can effectively improve the liver function of patients and relieve inflammatory response.
2020 Vol. 27 (17): 40-42 [
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Application of Octreotide and Pantoprazole combined with Raw Rhubarb in patients with acute pancreatitis
XU Wei-xi； XU Xi-lin； YAO Qiu-ping
Objective
To explore the application of Octreotide and Pantoprazole combined with Raw Rhubarb in patients with acute pancreatitis.
Methods
A total of 60 patients with acute pancreatitis treated in our hospital from January 2017 to January 2019 were selected as research subjects.They were divided into a control group (n=30)and observation group (n=30)by themethod of touching a ball at random.Patients in the control group were treated with Octreotide in combination with oral administration of Raw Rhubarb.In the observation group,participants were treated with Octreotide in combination with Pantoprazole and oral administration of Raw Rhubarb.The changes of abdominal distension disappearance time,abdominal pain disappearance time,bowel sounds recovery time,time for blood glucose to return to normal,healthy life scores and inflammatory factor levels in the two groupswere compared.
Results
In the observation group,the abdominal distension disappearance time,abdominal pain disappearance time,bowel sounds recovery time,time for blood glucose to return to normalwere shorter than those of the control group,and the differences were statistically significant(P＜0.05).The healthy life scores of the observation group after 3,6,12days after treatment were lower than those of the control group,and the differences were statistically significant(P＜0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the observation group were lower than those of the control group,the differences were statistically significant(P＜0.05).
Conclusion
Treating patients with acute pancreatitis by taking Octreotide combined with Pantoprazole and oral administration of Raw Rhubarb can effectively shorten the time of symptom alleviation,improve the quality of healthy life and control tumor necrosis factor,which has a great value of clinical application.
2020 Vol. 27 (17): 43-45转53 [
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Application of WeChat follow-up platform in safety management of inguinal hernia after ambulatory surgery
WU Zhi-hui； TAN Xing-ying； YAN Wei-hua
Objective
To explore the application effect ofWeChat follow-up platform in safetymanagement of inguinal hernia after ambulatory surgery.
Methods
A total of 150 patientswho underwent ambulatory tension-free inguinal hernia repair in Shunde Hospital of Guangzhou University of Chinese Medicine from January 2017 to June 2018 were selected as the research objects,and they were divided into WeChat group,primary group,tertiary group,community group and telephone group by the random number tablemethod,30 cases in each group.Patients in theWeChat group adopted theWeChat follow-up platform for 7 days,patients in the primary group were followed on the seventh day after surgery,patients in the tertiary group were followed on the first,third,and seventh days after surgery,patients in the community group were followed up for 7 days in community hospitals,and patients in the telephone group were followed up by telephone.The total incidence rate of postoperative complications,total satisfaction with complicationmanagement,total safety,economic expenditure for follow-up,time for follow-up and compliance of the five groups of patients were compared.
Results
The total incidence rate of complications of patients in WeChat group,primary group,tertiary group,community group and telephone group was 6.67%,10.00%,6.67%,6.67%,and 10.00%.There was no statistically significant difference in the total incidence rate of complications among the five groups(P＞0.05).The total satisfaction with complication management in the WeChat group was 96.67%,the primary group was 60.00%,the tertiary group was 73.33%,the community group was 70.00%,and the telephone group was 80.00%.The total safety of patients in theWeChat group was 96.67%,the primary group was 66.67%,the tertiary group was 83.33%,the community group was 86.67%,and the telephone group was 86.67%.The total satisfaction with complicationmanagement and total safety of patients in the WeChat group were higher than those in the other four groups,and those in the tertiary group,community group and telephone group were higher than those in the primary group,with statistically significant differences(P＜0.05).There were no statistically significant differences in the total satisfaction with complicationmanagement and total safety in the tertiary groups,the community group,and the telephone group (P＞0.05).There was no statistically significant difference in economic expenditure for follow-up between WeChat group and telephone group(P＞0.05).There was statistically significant difference in economic expenditure for follow-up in WeChat group and the other three groups(P＜0.05).The time for follow-up of theWeChat group and the other four groupswas statistically significant(P＜0.05).The compliance of the WeChat group and the other four groupswas statistically significant(P＜0.05).
Conclusion
WeChat follow-up platform in safetymanagement of inguinal hernia after ambulatory surgery can improve satisfaction and safety of patientswithout increasing postoperative complications,reduce economic expenditure,shorten the time of visits,and improve compliance,which can be promoted as a preferred safetymanagement scheme.
2020 Vol. 27 (17): 46-49转57 [
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Application effect of Mucopolysaccharide Polysulfate Cream combined with Desonide Cream in the treatment of chronic eczema
SONG Guo-qiang
Objective
To investigate the clinical effect of Mucopolysaccharide Polysulfate Cream combined with Desonide Cream in the treatment of chronic eczema.
Methods
A total of 110 patients with chronic eczema treated in our hospital from February 2017 to May 2018 were selected as the research objects.They were divided into experimental group and reference group according to the random number table method,with 55cases in each group.The control group patients were treated with Desonide Cream,the experimental group patients were treated with Desonide Cream and Mucopolysaccharide Polysulfate Cream.The clinical effect and recovery of symptoms were compared between the two groups.
Results
There were no significant differences in the symptoms scores of pruritus,thickness,elasticity and color before treatment between the two groups(P＞0.05).At 3and 5months after treatment,the symptoms scores of pruritus,thickness,elasticity and color of patients in the two groupswere lower than those before treatment,and the symptoms scores of pruritus,thickness,elasticity and color of patients in the experimental group were lower than those in the reference group at 3and 5months after treatment,and the differenceswere statistically significant(P＜0.05).The total effective rate of the experimental group was higher than that of the reference group,and the difference was statistically significant(P＜0.05).The incidence ofmild cauterization in the experimental group was lower than that in the reference group,and the recurrence rate at3and 5months after treatmentwas lower than that in the reference group,with statistically significant differences(P＜0.05).The incidence ofmild cauterization in the experimental group was lower than that in the reference group,and the recurrence rates of chronic eczema at 3and 5months after treatment were lower than those in the reference group,the differences were statistically significant(P＜0.05).
Conclusion
The use of Mucopolysaccharide Polysulfate Cream and Desonide Cream in patients with chronic eczema has excellent clinical effect,and it can improve the pruritus,thickness,elasticity,color,which isworth promoting.
2020 Vol. 27 (17): 50-53 [
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Effect com parison of nasal high-flow oxygen therapy and non-invasive positive pressure ventilation in the alternate treatment of acute exacerbation of chronic obstructive pulmonary disease with respiratory failure
SU Hang
Objective
To investigate the clinical effect of nasal high-flow oxygen therapy and non-invasive positive pressure ventilation (NIPPV)in the alternate treatment of acute exacerbation of chronic obstructive pulmonary disease(COPD)with respiratory failure.
Methods
From March 2018 to September 2019,80 patientswith acute exacerbation of COPD with respiratory failure who were treated in emergency intensive care unit of our hospital were selected as the research subjects.They were divided into two groups according to the random number tablemethod,each with 40 patients.In the control group,NIPPV was use,and in the observation group,alternate nasal high-flow oxygen therapy with NIPPV was applied.The lung function indicators 1week after treatment of the two groups were compared.The St George′s respiratory questionnaire(SGRQ)scores before and after treatment of the two groupswere compared.The time of using mechanical ventilator and hospital stay were compared between the two groups.The transfer to the general ward after improvement of the two groupswas also counted.
Results
Oneweek after treatment,the level of forced expiratory volume in 1second (FEV
1
)and the ratio of FEV
1
to forced vital capacity (FEV
1
/FVC)in the observation group were higher than those in the control group (P＜0.05).The SGRQ scores at 1d after treatment and 1week after treatment in both groupswere higher than those before the treatment(P＜0.05).The SGRQ scores at 1d after treatment and 1week after treatment of the observation group were higher than those of the control group(P＜0.05).In the observation group,the time of usingmechanical ventilator and hospital stay were shorter than those in the control group (P＜0.05).The proportion of patients in the observation group who were transferred to generalwards after improvementwas higher than that in the control group(P＜0.05).
Conclusion
For patientswith acute exacerbation of COPD combined with respiratory failure,the implementation of alternate nasal high-flow oxygen therapy and NIPPV can effectively improve patient′s lung function,ameliorate quality of life,shorten hospital stay,and enhance the therapeutic effect.
2020 Vol. 27 (17): 54-57 [
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Analysis of clinical characteristics of 60 patients with ischemic colitis
CHENG Xian-yong; WANG Kai; LI Yan-min; SHI Ning; WANG Jian
Objective
To summarize and analyze the clinical features of ischemic colitis (IC)to improve the understanding of the disease and the level of clinical diagnosis and treatment.
Methods
Retrospective analysis of the data including age,basic diseases,clinical symptoms,auxiliary examination,characteristics of colonoscopy,treatmentmethods,and prognosis in 60 patientswith IC admitted to our hospital from January 2016to August 2019 was conducted in a descriptiveway.
Results
IC occurred in 50 years old or older(83.33%).Forty-one patients(68.33%)had one ormore underlying diseases,with hypertension being the largest,accounting for 43.33%,followed by hyperlipidemia (26.67%)and diabetes(20.00%).Abdominal pain and bloody stoolwere themain clinicalmanifestations of IC.Elevated D-dimer was present in 76.67%of patients,and imaging tests such as ultrasound,CT enhanced scan,or CT angiography(CTA)were not sensitive.The scope of the lesion under enteroscope wasmainly affected in left colon.In terms of treatment,one patient was transferred to surgery due to complication of colon cancer,and the remaining patients were cured by conservativemedical treatments and discharged.
Conclusion
ICmostly occurs inmiddle-aged and elderly patients(≥50 years old)with underlying diseases.Laboratory and imaging tests are of limited value.If doubting the IC diagnosis,colonoscopy and timely intervention should be carried out as soon as possible.Most patients have a good prognosis.
2020 Vol. 27 (17): 58-61 [
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Correlation study of fractional exhaled nitric oxide with eosinophils percentage in induced sputum,eosinophils count in peripheral blood and lung function level in patients with bronchial asthma
ZHOU Zheng-hua； LIANG Zhi-yong； DENG Xiao-dong
Objective
To study the correlation of fractional exhaled nitric oxide (FeNO)with eosinophils percentage in induced sputum,eosinophils(EOS)count in peripheral blood and lung function level in patientswith bronchial asthma(BA),and to explore its significance in clinical diagnosis and treatment of BA.
Methods
A total of 47 cases of BA patients treated in Outpatient of Department of Respiration and Department of Inpatient,Chronic Disease Prevention Hospital of Qingyuan City from February 2018 to February 2019 were selected as the BA group,and 45cases of non-BA patients treated in department of respiration of our hospitalwere selected as the non-BA group during the same period.Lung function detector was used to detect the ventilation function of lung tissues in each group,and the forced expiratory volume for 1second expressed as a percentage of the forced vital capacity(FEV
1
%)was calculated.The EOS count in peripheral blood of patients in each group was detected by automatic blood cell analyzer.FeNO in each group was detected by nitric oxide (NO)detection kit,and hematoxylin-eosin (HE)stainingwas used to detect the percentage of induced sputum cells in each group.
Results
The FeNO,eosinophils percentage in induced sputum and peripheral blood EOS count of the BA group were higher than those of the non-BA group (P＜0.05),while FEV
1
%was lower than that of the non-BA group (P＜0.05).The FeNO of the BA group was positively correlated with the eosinophils percentage in induced sputum and peripheral blood EOS count(r=0.572,0.643,P＜0.05),but not correlated with FEV
1
%(r=-0.005,P＞0.05).
Conclusion
There is no significant correlation between the degree of respiratory airway obstruction and the severity of respiratory airway inflammatory response,so FeNO could not replace the physiological function detection of lung tissues.
2020 Vol. 27 (17): 62-64转68 [
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Clinical effect of Tiotropium Brom ide combined with Budesonide atom ization inhalation in the treatment of chronic obstructive pulmonary disease
DU Yue-jun
Objective
To investigate the clinical effect of Tiotropium Bromide combined with Budesonide atomization inhalation in the treatment of chronic obstructive pulmonary disease.
Methods
A total of 96patients with chronic obstructive pulmonary disease who were treated in outpatient clinic of our hospital from October 2018 to October 2019 were selected as subjects.They were divided into observation group and control group based on double-blind method,48 cases in each group.All patients received basic treatment,the control group was treated with Tiotropium Bromide,and the observation group was combined with Budesonide atomization inhalation therapy based on the control group.The clinical efficacy and adverse reactions of the two groups were compared and analyzed.The changes of lung function,oxygenation index and blood gas index before and after treatment in the two groupswere studied.
Results
The total effective rate in the observation group was higher than that in the control group,the difference was statistically significant(P＜0.05).After 2weeks of treatment,the levels of forced expiratory volume(FVC),forced expiratory volume in the first second (FEV
1
),ratio of FEV
1
to FVC (FEV
1
/FVC),oxygenation index,and arterial partial oxygen pressure(PaO
2
)in the observation group were higher than those in the control group,and partial pressure of carbon dioxide in artery (PaCO
2
)level was lower than that in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).
Conclusion
Tiotropium Bromide combined with Budesonide atomization inhalatio can achieve good clinical efficacy in treating chronic obstructive pulmonary disease,which can significantly improve the hypoxic state and lung function of patients,and has high safety.
2020 Vol. 27 (17): 65-68 [
Abstract
] (
84
)
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69
Influence of short-cut endotracheal intubation on off-line success rate in patients with acute exacerbation of chronic obstructive pulmonary disease
ZENG You-qiang； WEN Qiu-hong
Objective
To investigate the influence of short-cut endotracheal intubation on the offline success rate of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).
Methods
Retrospective analysis of 80 patients with AECOPD who had undergone oral and tracheal intubation mechanical ventilation and blood gas analysis in the department of critical caremedicine from January 2019 to August 2019 in our hospitalwere selected as the experimental group.From January to August 2018,the 80 patients with AEDPD who underwentmechanical ventilation and blood gas analysis of the intubation in the ICU were shown to have typeⅡrespiratory failure and who had met the criteria for weaning were selected as the control group.Both groups of patients were given conventionalmedical treatment,and invasive mechanical ventilation was performed through oral intubation.When the patients reached the offline standard,the control group underwent SBT according to the routine operation.The experimental group removed the tracheal intubation connector and shortened the length of the tracheal tube to 25cm after the development line,and then performed SBT.The indexes of respiratory rate,heart rate,shallow respiratory index,oxygenation index,pulse oximetry,tidal volume,oral closure pressure,and lung dynamic compliance after the extubation and offline success rate were compared between the two groups.
Results
The respiratory rate,heart rate and shallow respiratory index of the experimental group were lower than those of the control group,and the differences were statistically significant(P＜0.05).The oxygenation index,pulse oximetry,tidal volume,and oral closure pressure,the lung dynamic compliance in the experimental group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The success rate of SBT in the experimental group was 93.75%,which was higher than that in the control group (73.75%)(P＜0.05).The intubation rate of the experimental group was 3.75%,which was lower than that of the control group(10.00%)(P＜0.05).The offline success rate in the experimental group was 90.00%,which was higher than that of the control group (63.75%),and the difference was statistically significant(P＜0.05).
Conclusion
When the endotracheal tube is cut short,the success rate of passing SBT test,weaning and extubation of AECOPD patients is increased,the length of stay in ICU and the cost of hospitalization is reduced,the curative effect is obvious,and social and economic benefits can be produced.
2020 Vol. 27 (17): 69-72 [
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] (
66
)
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73
Effect of directional soft-channel intracranial hematoma drainage combined with autologous serum in the treatment of hypertensive cerebral hemorrhage
QI bo
Objective
To investigate the effect of directional soft-channel intracranial hematoma drainage combined with autologous serum in the treatment of hypertensive cerebral hemorrhage.
Methods
From January 2018 to June 2019,70 patientswith hypertensive cerebral hemorrhage treated in our hospitalwere selected as the research subjects.They were divided into control group (n=35)and observation group (n=35)according to the random number table method.In the control group,directional soft-channel intracranial hematoma drainage combined with Urokinase was used,and in the observation group,directional soft-channel intracranial hematoma drainage combined with autologous serum was applied.The total clinical treatment efficiency,total incidence of complications,and changes in the Glasgow coma scale(GCS)and Scandinavian stroke scale(SSS)scores of patients in the two groupswere compared.
Results
The total effective rate of clinical treatment in the observation group was 97.14%,higher than 82.86%in the control group,and the difference was statistically significant(P＜0.05).The total incidence of complications in the observation group was 5.71%,lower than 22.86%in the control group,and the difference was statistically significant(P＜0.05).Before treatment,there were no significant difference in GCSor SSS scores between the two groups(P＞0.05).After treatment,the GCS scores in the two groupswere higher than those before treatment,the SSS scoreswere lower than those before treatment,in the observation group,the GCS score was higher than that of the control group,the SSS score was lower than that of the control group,and the differenceswere statistically significant(P＜0.05).
Conclusion
Patientswith hypertensive intracerebral hemorrhage treated with directional soft-channel intracranial hematoma drainage combined with autologous serum obtains remarkable effects,which can greatly improve the GCS and SSS scores of patients,and improve their coma and neurological injury with a high total effective rate and few complications.
2020 Vol. 27 (17): 73-76 [
Abstract
] (
77
)
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77
Clinical effect of Baclofen combined with Carbamazepine in the treatment of primary trigem inal neuralgia
HE Xin
Objective
To explore the effect of Baclofen combined with Carbamazepine in the treatment of primary trigeminal neuralgia,and to provide reference for clinicians to choose a reasonable regimen.
Methods
A total of 88 patientswith primary trigeminal neuralgia diagnosed and treated in our hospital from July 2018 to June 2019 were selected as the research objects.According to the random number tablemethod,the research objects were divided into control group and experimental group,44cases in each group.The control group was given Carbamazepine treatment,and the experimental group was treated with the combination of Baclofen and Carbamazepine.The clinical effect,pain and adverse reactions were compared between the two groups.
Results
The total clinical effective rate of the experimental group(95.45%)was higher than that of the control group(79.55%),the difference was statistically significant(P＜0.05).There was no significant difference between the two groups in visual analogue scale (VAS)score before treatment(P＞0.05).After treatment,the VAS scores of the two groups were lower than those before treatment,the differences were statistically significant(P＜0.05),and the VAS score of the experimental group was lower than that of the control group,the difference was statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).
Conclusion
In the treatment of patientswith primary trigeminal neuralgia,the combination of Baclofen and Carbamazepine has a significant clinical effect,can significantly improve the symptoms of patients,and it has good security.It is recommended to promote the clinical application.
2020 Vol. 27 (17): 77-79 [
Abstract
] (
69
)
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80
Com parison of clinical effect of intensity modulated radiotherapy and conventional radiotherapy in the treatment of locally advanced nasopharyngeal carcinoma
YAN Shao-cong； YING Xue-ming； XIONG Jian-ping； ZHAO Jian-hua
Objective
To compare the clinical effect of intensitymodulated radiotherapy (IMRT)and conventional radiotherapy(CRT)in the treatment of locally advanced nasopharyngeal carcinoma.
Methods
Totally 85patientswith locally advanced nasopharyngeal carcinoma admitted into the First Affiliated Hospital of Nanchang University from January 2010 to December 2013were selected as research subjects.They were divided into the CRT group(n=39)and the IMRT group (n=46)according to different treatmentmethods.The CRT group was treated with CRT,and the IMRT group was treated with IMRT.The clinical remission rate,5-year survival rate without local progression,5-year survival rate without distantmigration,overall survival rate and the incidence of early and late adverse reactions were compared between the two groups.
Results
The clinical remission rate of the IMRT group was 69.5%,which was higher than that of the CRT group accounting for 25.6%,the difference was statistically significant(P＜0.05).The degree of early radiation loss of drymouth and acute skin reactions in the IMRT group were lighter than those of the CRT group,the differenceswere statistically significant(P＜0.05).The degree of late radiation loss of drymouth,skin fibrosis,and difficulty in openingmouth in the IMRT group were lighter than those of the CRT group,and the differenceswere statistically significant(P＜0.05).The 5-year survival ratewithout local progression in the IMRT group was 21.7%,which was higher than that of the CRT group accounting for 13.7%,the differencewas statistically significant(P＜0.05).
Conclusion
Applying IMRT to patientswith locally advanced nasopharyngeal carcinoma can significantly increase the clinical remission rate,alleviate patients′adverse reactions and prolong the survival time of patientswho had no local progression.
2020 Vol. 27 (17): 80-84 [
Abstract
] (
69
)
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85
Clinical effect of Docetaxel combined with Apatinib in the second-line treatment of advanced gastric cancer
LIN Xiao-wei； LIN You-en； WANG Xiao-fen
Objective
To explore the clinical effect of Docetaxel combined with Apatinib in the second-line treatment of advanced gastric cancer.
Methods
A total of 60 patients with second-line treatment advanced gastric cancer who came to our hospital from July 2018 to August 2019 were selected as the research objects,and they were divided into reference group(30 cases)and experimental group(30 cases)by random number tablemethod.The patients in the reference group used Docetaxel.In the experimental group,patientswere treated with Docetaxel combined with Apatinib.The disease remission,adverse reactions,and total treatment satisfaction were compared between the two groups.The nutritional status scores before and after treatment,quality of life scores (including functional items,symptom items)and serum tumor markers (sugar carbohydrate antigen [CA19-9],carbohydrate antigen sugar chain antigen 72-4[CA72-4])measured valueswere observed and recorded in the two groups.
Results
The objective remission rate of the experimental group was higher than that of the reference group,the difference was statistically significant(P＜0.05).The total incidence of adverse reaction of the experimental group was lower than that of the reference group,the difference was statistically significant(P＜0.05).The total treatment satisfaction rate of the experimental group was higher than that of the reference group,the difference was statistically significant(P＜0.05).There were no significant differences between the two groups in the nutritional status scores before treatment(P＞0.05).After treatment,the nutritional status score of the experimental group was higher than that of the reference group,and the difference was statistically significant(P＜0.05).Therewere no significant differences between the two groups in functional item scores and symptom item scores before treatment(P＞0.05).After treatment,the score of functional items in the experimental group was higher than that in the reference group,the score of symptom item was lower than that in the reference group,and the differences were statistically significant(P＜0.05).There were no significant differences between the two groups in the indexesmeasured values of CA9-9 and CA72-4before treatment(P＞0.05).After treatment,the indexesmeasured values of CA19-9 and CA72-4in the experimental group were lower than those in the reference group,and the differenceswere statistically significant(P＜0.05).
Conclusion
The combination of Docetaxel and Apatinib in the second-line treatment of patientswith advanced gastric cancer has a good clinical effect and isworth promoting.
2020 Vol. 27 (17): 85-88转92 [
Abstract
] (
78
)
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89
Application effect of ultrasound-guided im p lantable infusion port in breast cancer chemotherapy
PENG Rong-rong； LI Yu
Objective
To explore the application effect of ultrasound-guided implantable infusion port in breast cancer chemotherapy.
Methods
The clinical data of 68 breast cancer patients admitted into our hospital from January 2018 to June 2019 were retrospectively analyzed.Those patientswere divided into the control group(n=35)and the observation group (n=33)according to different ways of catheterization.Central venous catheterization was used in the control group,and ultrasound-guided implantable infusion port was used in the observation group.The effectiveness of catheterization(success rate of catheterization,catheter indwelling time,interval time of cathetermaintenance and operation time of cathetermaintenance),comfort level and complications were compared between the two groups.
Results
There was no significant difference in the success rate of catheterization between the two groups(P＞0.05).The catheter indwelling time and interval time of cathetermaintenance in the observation group were longer than those of the control group,while the operation time of cathetermaintenance was shorter than that of the control group,with statistical significance (P＜0.05).The comfort level of catheterization in the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).The total incidence of complications in the observation group was lower than that of the control group,and the difference was statistically significant(P＜0.05).
Conclusion
Ultrasound-guided implantable infusion port has high effectiveness,long indwelling time,high comfort level,and can reduce complications after catheterization.
2020 Vol. 27 (17): 89-92 [
Abstract
] (
75
)
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93
Influence of one-stage resection and anastomosis on colorectal cancer with intestinal obstruction
LIU Dong； ZHANG Yue-tao； CHEN Qiu-nan
Objective
To investigate the treatment experience of one-stage resection and anastomosis on colorectal cancer with intestinal obstruction.
Methods
A total of 50 patients with colorectal cancer and intestinal obstruction admitted to our hospital from April 2018 to January 2019 were selected as the study subjects,and they were divided into the observation group (25cases)and the control group (25cases)according to the random number tablemethod.The control group was treated with one-stage resection and second-stage anastomosis.The observation group was treated with one-stage resection and one-stage anastomosis.The total incidence of postoperative complications,speeding status and the number of hospitalizationswere compared between the two groups.
Results
The speeding status in the observation group was less than that of the control group,the difference was statistically significant(P＜0.05).The number of hospitalizations in the observation group was less than that of the control group,and the difference was statistically significant(P＜0.05).There was no significant differcne in the total incidence of postoperative complications between the two groups(P＞0.05).
Conclusion
The patientswith colorectal cancerwith intestinal obstruction treated with first stage resection and first stage anastomosis,which is not significantly increase the postoperative complications,and the cost of surgical treatment is low,the number of hospitalization is less,so the application value in clinical practice is higher.
2020 Vol. 27 (17): 93-95 [
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] (
65
)
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Influence of laparoscopic radical surgery on Tlym phocytes and serum cortisol levels in elderly patients with colorectal cancer
YAO Lei； HAO Shun-xin； ZHANG Jing
Objective
To investigate the influence of laparoscopic radical surgery on T lymphocytes and serum cortisol levels in elderly patientswith colorectal cancer.
Methods
A total of 90 elderly patientswith colorectal cancer who were admitted to our hospital from May 2017 to June 2019 were enrolled in the study.They were divided into the experimental group and the control group according to the random number table methods,45cases in each group.The experimental group underwent laparoscopic radical surgery,and the control group underwent open surgery.Perioperative indicators,serum cortisol levels,the level of T lymphocytes and the total incidence of complication were compared between the two groups.
Results
There was no significant difference in operation time between the two groups (P＞0.05).The blood loss in the experimental group was lower than that in the control group,the hospitalization time,feeding time and anus exhaust time in the experimental group were shorter than those in the control group,the differenceswere statistically significant(P＜0.05).The levels of cortisol,CD3
+
,CD4
+
,CD4
+
/CD8
+
in the experimental group were(11.43±3.09)μg/ml,(54.19±6.68)%,(34.21±4.88)%,1.13±0.25,whichinthecontrolgroupwere(15.28±2.76)μg/ml,(48.26±6.09)%,(29.15±5.04)%,0.97±0.27,the differenceswere statistically significant(P＜0.05).Therewas no significant difference in the level of postoperative CD8
+
between the two groups(P＞0.05).The total incidence of postoperative complications in the experimental group was 4.44%,which was lower than that in the control group(22.22%),the difference was statistically significant(P＜0.05).
Conclusion
Laparoscopic radical operation is safe for patientswith elderly colorectal cancer,which can effectively reduce intraoperative blood loss,relieve stress response,regulate immune function and shorten postoperative recovery time.
2020 Vol. 27 (17): 96-98转102 [
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] (
63
)
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Effect and safety of homothermal hypertherm ic-itraperitoneal chemotherapy combined with system ic intravenous chemotherapy in treatment of malignant ascites
ZHANG Yang； QIAN Hong； CHENG Xiao-fei； SU Xu-Jun； LYU Yang； ZHONG Cheng； ZHOU Ting
Objective
To explore effect and safety of homothermal hyperthermic-itraperitoneal chemotherapy(HIPEC)combined with systemic intravenous chemotherapy (SIC)in treatment ofmalignant ascites.
Methods
Eightymalignant ascites patients admitted to our hospital from June 2015to May 2018 were enrolled.They were divided into observation group and control group by random number tablemethod,40 cases in each group.The control group was treated with SIC.On this basis,observation group was treated with homothermal HIPEC.The treatment effectwas compared between the two groups.
Results
The total efficiency rate in observation group was higher than that in control group(95.00%vs.80.00%)(P＜0.05).After treatment,in terms of quality of life scale,scores of physical function,physical role,physical pain,overall health,vitality,social function,emotion role and mental health were higher in observation group than those in control group (P＜0.05).There was no significant difference in incidence of toxic and side effect between the two groups(P＞0.05).
Conclusion
Homothermal HIPEC combined with SIC is safe and effective formalignant ascites.
2020 Vol. 27 (17): 99-102 [
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] (
72
)
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9
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103
Correlation study on heart Tei index and uterine arterial spectrum in patients with gestational hypertension and its clinical application
LIU Yong； ZHUANG Xiao-lan； LIU Qing▲
Objective
To investigate the correlation between heart Tei index and uterine arterial spectrum in patients with gestational hypertension and its clinical application value.
Methods
The clinical data of 169 pregnantwomen with gestational hypertension and 100 normal pregnantwomen who were diagnosed and treated in the hospital from January 2016to January 2020were retrospectively analyzed.The pregnant women with gestational hypertension were divided into groups according to the severity of the disease.The clinical data of 89 pregnantwomen with preeclampsia were included in group A,the clinical data of 80 pregnantwomen with severe preeclampsia were included in group B,and the clinical data of 100 normal pregnantwomen with normal blood pressure were included in group C.The three groups of pregnantwomen underwent ultrasonic cardiogram examination,and the Tei index of left and right ventricles and uterine arterial spectrum(uterine artery Doppler ratio of systolic to diastolic velocity[S/D])were calculated.The correlation between heart Tei index and S/D was analyzed.
Results
After detection,the Tei index and S/D in group A and group B were higher than those in group C,and which in group B was higher than that in group A,and the differenceswere statistically significant(F=2550.95,3577.35,P=0.000,0.000).Pearson analysis showed that Tei index was positively correlated with S/D in patientswith gestational hypertension (r=0.778,P=0.000).
Conclusion
Themore severe the gestational hypertension,the higher the heart Tei index and the S/D index,and Tei index is positively correlated with S/D.
2020 Vol. 27 (17): 103-105 [
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] (
57
)
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106
Effect of half-day outpatientmanagement on patients with gestational diabetes
FENG Li-hui； YE Xiao-dan； ZHANG Yuan； ZHANG Yuan-feng； CHEN Mei-jun； CHEN Lu
Objective
To explore the effect of half-day outpatientmanagement on patients with gestational diabetes mellitus.
Methods
A total of 120patientswith gestational diabeteswho were treated in our hospital from June 2018 to June 2019 were selected as the research objects,and they were divided into control group (60 cases)and observation group (60 cases)according to the simple randomization method.The control group adopted the outpatient nutrition consultationmethod,and the observation group adopted the half-day outpatientmanagementmethod.The blood glucose levels,related knowledge mastery,maternal and child outcomes were compared between the two groups.
Results
The fasting blood glucose,2h postprandial blood glucose and glycated hemoglobin levels in the observation group were lower than those in the control group,and the differenceswere statistically significant(P＜0.05);the knowledge of the concept of gestational diabetesmellitus,reasonable diet,reasonable exercise,and the importance of blood glucosemonitoring in the observation group were higher than those of the control group,the differenceswere statistical significance(P＜0.05);the incidence of cesarean section,preterm birth,and neonatal hypoglycemia in the observation group were lower than those in the control group,and the differenceswere statistically significant(P＜0.05);there was no significant difference in the incidence ofmacrosomia between the two groups (P＞0.05).
Conclusion
The use of half-day outpatient management for gestational diabetesmellitus patients can effectively control their blood glucose levels,improve their knowledge of disease-related knowledge,and reduce the occurrence of abnormalmaternal and child outcomes.
2020 Vol. 27 (17): 106-108 [
Abstract
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60
)
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109
Oral exercise intervention promotes oral feeding in premature infants
ZHENG Fang-ming； FANG Li-hua； LIU Li； CHEN Hui-juan； CHEN Zhi-fang； SHANGGUAN Hua-ying
Objective
To explore the effect of oral exercise intervention on oral feeding in premature infants.
Methods
A total of 60 premature babies admitted in our hospital from October 2018 to August 2019 were selected as the subjects of this study.They were divided into the study group and the control group according to the random number table method,with 30 cases in each group.Conventional nursingmethodswas given in the control group,and the study group was given oral exercise intervention of breastmilk on the bases of the control group.The feeding performance,weight gain and adverse reactions were compared between the two groups.
Results
The feeding efficiency at the beginning of oral feeding,the intake of oral feeding,and the feeding efficiency of the whole oral feeding in the study group were higher than those of the control group,the differenceswere statistically significant(P＜0.05).The body weight of preterm infants in the study group at the time of complete feeding and discharge were higher than those in the control group,the differenceswere statistically significant(P＜0.05).The incidence of adverse reactions in the study group was lower than that in the control group (P＜0.05).
Conclusion
Oral exercise intervention of breastmilk can effectively promote the improvement of oral feeding in premature infants,and promote the growth and development of premature infants,which help to reduce the risk of adverse reactions in feeding.
2020 Vol. 27 (17): 109-111 [
Abstract
] (
69
)
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112
Application effect of birth dance in the puerpera at the third trimester
LIU Mei-jin； LI Jin-shang； LI Yan-mei
Objective
To explore the application effect of birth dance in puerpera at the third trimester.
Methods
50 puerpera at the third trimesterwhowere admitted to our hospital from June 2018 to June 2019 were selected as the research subjects.They were divided into experimental group and control group according to the random number table method,each had 25cases.The control group accepted routinematernal health interventions.The experimental group accepted birth dance intervention on the basis of the control group.After the intervention,the childbirth fear scores,the time of each birth course,pregnancy outcomes,and neonatal outcomeswere compared between the two groups.
Results
The scores of fear of pain and injury,fear of children′s health,fear of loss of control,and fear of hospital intervention and environment after intervention in the experimental group were lower than those in the control group,and the differenceswere statistically significant(P＜0.05).The first,second,third,and total labor stageswere shorter than those in the control group,and the differenceswere statistically significant(P＜0.05).The rate of cesarean section was lower than that in the control group,and the proportion of 1min Apgar score＞7 pointswas higher than that in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of neonatal asphyxia between two groups(P＞0.05).
Conclusion
Birth dance has a good effect in the third trimester and during delivery.It can effectively reduce the fear of childbirth,shorten the time of each birth course,reduce the rate of cesarean section,and improve the outcomes of newborns and pregnancy.
2020 Vol. 27 (17): 112-114 [
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71
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115
Application effect of breast health exercises in prim iparas
JIAN Xiao-jin； RAO Hong-ying ； WANG Ping-hua
Objective
To explore application effect of breast health exercises in primiparas.
Methods
A total of 80 primiparaswhowere admitted to the hospital during the period from July 2018 to June 2019 were enrolled as study objects.They were divided into the control group(40 cases)and the observation group(40 cases)by random number table method.The control group underwent routine breast nursing intervention,while the observation group underwent breast health exercises intervention on basis of the control group.Thematernal lactation,meconium emptying time and daily weight loss in both groupswere statistically analyzed.The visual analogue scale (VAS)was applied to evaluate breast pain degree before and after intervention.The nursing satisfaction and total incidence of complications were compared between the two groups.
Results
The good rate of lactation in the observation group was higher than that in the control group,the difference was statistically significant(P＜0.05).After intervention,the VAS score and the total incidence of complications in the observation group were lower than those in the control group,while nursing satisfaction in the observation group was higher than that in the control group,the differences were statistically significant(P＜0.05).The neonatal meconium emptying time in the observation group was shorter than that in the control group,while daily weight gain in the observation group was greater than that in control group,the difference was statistically significant(P＜0.05).
Conclusion
Breast health exercises intervention for primiparas can improve good rate of lactation and nursing satisfaction,alleviate breast pain degree,shortenmeconium emptying time,and reduce incidence of complications.
2020 Vol. 27 (17): 115-117转121 [
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72
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118
Clinical effect of hysteroscopic hysterom yoma resection for submucosal uterine fibroids
CHEN Chuang
Objective
To investigate the clinical effect of hysteroscopic hysteromyoma in the treatment of submucous uterinemyoma.
Methods
A total of 112patientswith submucous uterinemyoma treated in our hospital from June 2016to June 2018 were selected as the research subjects.According to the wishes and physical conditions of the patients,the surgicalmethods were determined.These patients were divided into the control group (n=44)and the observation group (n=68)according to the differences in surgicalmethods.The control group was treated with conventional open hysteromyomectomy and the observation group was treated with hysteroscopic hysteromyoma.The operation and postoperative conditionswere compared between the two groups,and the recurrence rate was counted after 12months followup for 24months.
Results
①During the operation in the observation group,the amount of bleeding during operation was less than that of the control group,the amount of vaginal bleeding at 24hours was less than that of the control group,the postoperative exhaust time was shorter than that of the control group,the first time of getting out of bed was shorter than that of the control group,and the hospitalization time was shorter than that of the control group,the differences were statistically significant(P＜0.05).②The incidence of operative complications in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).③All patients were followed up for 12and 24months,and all patients were followed up for 16months,but there was no significant difference in satisfaction rate between the two groups (P＞0.05).
Conclusion
Hysteroscopic surgery for submucosal uterine fibroids can shorten the operation time,reduce the amount of bleeding,promote postoperative exhaustion,promote postoperative recovery,and reduce complications.Its long-term treatment is ideal.
2020 Vol. 27 (17): 118-121 [
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73
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122
Changes and significance of C-reactive protein,serum am yloid A and leukocyte counts in children with Mycoplasma pneumonia
LIAO Yao-hua; WANG Pei; XIAO Dan-xia; LIU Ying-xian; JIANG Feng-chao
Objective
To investigate the changes and significance of C-reactive protein(CRP),serum amyloid A(SAA)and white blood cell count(WBC)in children with Mycoplasma pneumonia(MP).
Methods
A retrospective analysiswas performed on 200 children with MP who were treated in our hospital from June 2016to June 2019.Of the 200 children,165had mild MP and 35had severe MP.Another 50 healthy children who underwent physical examination in our hospital at the same time were selected as the control group.The changes of serum CRP,SAA,WBC content in the two groups of children in the acute phase and the recovery period after treatment and the healthy children in the control group were measured.
Results
In the acute period,the CRP and SAA contents of children in the severe group were higher than those in themild group,and the differenceswere statistically significant(P＜0.05);compared with themild group,the WBC content in the children in the severe group was not different statistical significance (P＞0.05).After treatment,the CRP and SAA contents in the recovery group of the severe group and the mild group were lower than those in the acute phase,and the differenceswere statistically significant(P＜0.05);comparison ofWBC content in recovery period and acute period in severe group,the difference was not statistically significant(P＞0.05).
Conclusion
CRP and SAA have good application value in judging the severity of MP children.WBC can only be used as a reference for the existence of inflammatory reactions,and it cannot judge the severity of the disease.
2020 Vol. 27 (17): 122-124 [
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72
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Effect of Progesterone Capsules combined with Estradiol Valerate on amenorrhea and anovulatory dysfunction uterine bleeding
LI Yan
Objective
To investigate the effect of Progesterone Capsules combined with Estradiol Valerate in the treatment of uterine bleeding caused by dysmenorrhea and anovulatory dysfunction.
Methods
From January 2018 to March 2019,60 patients with uterine bleeding caused by dysmenorrhea and anovulatory dysfunction treated in our hospital were selected and divided into two groups according to random number tablemethod,30 cases in each group.The control group was treated with Medroxyprogesterone Acetate Tablets and Estrogen Valerate Tablets,while the observation group was treated with Progesterone Capsules and Estriol Valerate Tablets.Themenstrual cycle,menstrual period and intimal thickness of the two groups were compared before and after treatment,and the total effective rate of the two groups was observed and calculated,the adverse reactions such as dizziness,nausea and lethargy were recorded.
Results
Themenstrual cycle of the two groups after treatmentwas shorter than that before treatment,themenstrual period was shorter than that before treatment,and the endometrial thickness was lower than that before treatment,the differenceswere statistically significant(P＜0.05),but therewas no significant difference inmenstrual cycle,menstrual period and endometrial thickness between the two groups(P＞0.05).The total effective rate of the observation group(96.67%)was higher than that of the control group(80.00%),the difference was statistically significant(P＜0.05).The total incidence of adverse reactions in the observation group (10.00%)was lower than that of the control group (40.00%),and the difference was statistically significant(P＜0.05).
Conclusion
While the patientswithmenstrual closure and anovulatory dysfunctional uterine bleeding are treated with Estridiol Valerate Tablets,the effect of Progesterone Capsules is obvious，which can significantly improve themenstrual cycle,menstrual period and intimal thickness of the patients,the total effective rate is higher,the incidence of adverse reactions is low,and the safety ofmedication is higher.
2020 Vol. 27 (17): 125-127转131 [
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128
Clinical effect of laparoscopic-assisted transanal gradient excision of rectalmuscle sheath and modified Soave operation on Hirschsprung′s disease in children
ZHAO Jing-quan； ZHANG Zheng-mao ； ZHOU Peng
Objective
To investigate the clinical effect of laparoscopic-assisted transanal gradient excision of rectal muscle sheath and modified Soave operation on Hirschsprung′s disease in children.
Methods
A total of 100 caseswith Hirschsprung′s disease admitted in our hospital from May 2015to August 2019 were divided into two groups according to the random number table method,50 cases in each group.The observation group received laparoscopic-assisted transanal gradient resection of rectalmuscle sheath layer by layer and modified Soave operation,the control group received traditional transanalmodified Soave operation.The length of the colon resection,the length of the surgical incision,the surgical-related indicators (surgery time,intraoperative bleeding,exhaust time,postoperative hospital stay),complications,pain of postoperative 1day,1week,and 1month were compared between two groups.
Results
The length of colon resection and incision in the observation group were shorter than those in the control group,the operation time in the observation group was shorter than that in the control group,the intraoperative hemorrhage was less than that in the control group,the anal exhaust time was earlier than that in the control group,the postoperative hospitalization time was shorter than that in the control group,the total proportion of intestinal obstruction,intestinal fistula,infection and anemia in the observation group were lower than those in the control group,the postoperative pain scores of postoperative 1day,1week,and 1month in the observation group were lower than those in the control group,the differenceswere all statistically significant(P＜0.05).
Conclusion
For Hirschsprung′s disease in children,laparoscopic assisted transanal gradient excision of rectalmuscle sheath layer by layer modified Soave operation has less trauma,rapid postoperative recovery,fewer complications and low postoperative pain in children.
2020 Vol. 27 (17): 128-131 [
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64
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132
Effect of Metform in combined with Insulin therapy on blood glucose and maternal and infant outcome in patients with gestational diabetesmellitus
ZENG Hui
Objective
To explore the effect of Metformin combined with Insulin therapy on blood glucose and maternal and infantoutcome of gestational diabetesmellitus(GDM).
Methods
From January 2018 to June 2019,80 patientswith GDM admitted to Shenyangmaternal and child health hospital were selected as the research objects.According to the random number tablemethod,the research objectswere divided into control group and experimental group,40 cases in each group.The control group was treated with Insulin,and the experimental group was treated with Metformin and Insulin.The blood glucose level,pregnancy outcome and neonatal adverse outcome were compared between the two groups.
Results
The fasting blood glucose,2h postprandial blood glucose,and glycated hemoglobin levels in experimental group were lower than those in control group,the differenceswere statistically significant(P＜0.05);the rates of hypertension,cesarean section,pre-eclampsia and preterm delivery of the experimental group were lower than those in control group,the differenceswere statistically significant(P＜0.05);the incidence of adverse neonatal outcomes of the experimental group was lower than that in control group,the difference was statistically significant(P＜0.05).
Conclusion
The combined medication of Metformin and Insulin can not only improve the blood glucose level,but also reduce the adverse pregnancy outcome and neonatal adverse outcome.This treatment regimen is safe and worthy of clinical application.
2020 Vol. 27 (17): 132-134 [
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57
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135
Application effect of com prehensive nursing on diabetic cataract patients after phacoemulsification
ZHU Qi-lan
Objective
To explore the application effect of comprehensive nursing on diabetic cataract patients after phacoemulsification.
Methods
From February 2017 to September 2019,60 patientswith diabetic cataractwere selected as the study subjects.They were divided into control group(n=30)and observation group(n=30)according to the drawing of lots.The visual acuity,blood glucose level,hospitalization time,incidence of corneal edema,total complications and nursing satisfaction were compared between the two groups.
Results
After nursing,the visual acuity of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05),and the visual acuity of the observation group after nursing was higher than that before nursing,and the difference was statistically significant(P＜0.05).The fasting blood glucose and postmeal 2h blood glucose level in the observation group were lower than those in the control group,and the differenceswere statistically significant(P＜0.05),and the fasting blood glucose and postmeal 2h blood glucose levels in the observation group were lower than those before nursing,and the differenceswere statistically significant(P＜0.05).The hospitalization time of the observation group was shorter than that of the control group,and the difference was statistically significant(P＜0.05).The incidence of corneal edema and total incidence of complications in the observation group were lower than those in the control group,and the differenceswere statistically significant(P＜0.05).The overall satisfaction rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).
Conclusion
Comprehensive nursing in the treatment of diabetic cataract is beneficial to improve its curative effect,improve the visual acuity and blood glucose level of the patients,reduce the occurrence of corneal edema and complications after operation,shorten the hospitalization time and improve the nursing satisfaction,which isworth popularizing and using in clinic.
2020 Vol. 27 (17): 135-137转141 [
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63
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138
Clinical effct of calcium hydroxide paste combined with root canal therapy in treatment of pulpitis or apical periodontitis
ZHOU Yu-jun
Objective
To investigate the effect of calcium hydroxide paste combined with root canal therapy in treatment of pulpitis or apical periodontitis.
Methods
From January 2017 to October 2018,100 pulpitis and apicitis patientswere selected as the research object,according to the randomization envelopemethod,they were divided into experimental group(50 cases)and control group(50 cases).The control group was treated with zinc oxide iodoform clove oil cement and root canal therapy,while the experimental group was treated with calcium hydroxide paste combined with root canal therapy.The therapeutic effect of the two groupswere compared in terms of gingival index (GI),periodontal pocket probing depth(PD),bleeding index(BI),plaque index(PLI)score and inflammatory factor level.
Results
The total effective rate in the experimental group was higher than that in the control group,the difference was statistically significant(P＜0.05).The scores of GI,PD,BIand PLIafter treatment in the two groupswere lower than those before treatment,and the differenceswere statistically significant(P＜0.05).The scores of GI,PD,BIand PLI in the experimental group were lower than those in the control group after treatment,the differenceswere statistically significant(P＜0.05).The levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-8(IL-8)and interleukin-6(IL-6)after treatment in the two groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).After treatment,TNF-α,IL-1β,IL-8 and IL-6in the experimental group were lower than those in the control group,the differenceswere statistically significant(P＜0.05).
Conclusion
Calcium hydroxide paste combined with root canal therapy has a good effect on pulpitis or apicitis patients,which can better reduce the pain degree of patients and is of great significance.
2020 Vol. 27 (17): 138-141 [
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51
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Application effect of early pulpotom y decom pression and drainage in the treatment of acute pulpitis
CHEN Ning-ning； QIN Si-si
Objective
To explore the applicatiion effect of early pulpotomy decompression and drainage in the treatment of acute pulpitis.
Methods
Eighty patients with acute pulpitis treated in our hospital from March 2017 to March 2019 were divided into a control group and an observation group by drawing lots and 40 cases each.The control group was given conservative treatment,and the observation group was given early pulpotomy decompression and drainage.The clinical efficacy,pain,number of treatments,and the total incidence of complications were compared between the two groups.
Results
The total effective rate of treatment in the observation group was higher than that in the control group (P＜0.05).There was no significant difference in pain scores between the two groups before treatment(P＞0.05).After treatment,the pain scores of the two groupswere lower than those before treatment,and the pain score of the observation group was lower than that of the control group (P＜0.05).The number of treatments in the observation group was less than that of the control group(P＜0.05).The total incidence of complications in the observation group was lower than that of the control group (P＜0.05).
Conclusion
The application of early pulpotomy decompression and drainage in the treatment of acute pulpitis has a significant effect,which can effectively improve the overall treatment effect,relieve pain,reduce the number of treatments,and has high clinical promotion value.
2020 Vol. 27 (17): 142-144 [
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61
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145
Application of endoscopic tympanoplasty in patients with chronic otitis media
WEI Lin； LI Hua-ying； XUAN Zi-cai
Objective
To explore the application of endoscopic tympanoplasty in patients with chronic otitis media.
Methods
A total of 200 patientswith chronic otitismedia admitted to our hospital from January 2018 to January 2019 were selected as the study objects.They were randomly divided into the observation group (100 cases)and the control group (100 cases)according to the computer distribution.The observation group was treated with endoscopic tympanoplasty,while the control group was treated with conventional treatment.The total incidence of adverse reactions,lesion eradication rate,hearing recovery rate,recurrence rate and dry ear rate of the two groups were compared.
Results
The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The eradication rate of lesions in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The hearing recovery rate in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The recurrence rate of the observation group was lower than that of the control group,and the difference was statistically significant(P＜0.05).The dry ear rate in the observation group was higher than that in the control group,and the differencewas statistically significant(P＜0.05).
Conclusion
Endoscopic tympanoplasty has significant advantages in the incidence of adverse reactions,lesion eradication and hearing recovery in the treatment of chronic otitismedia.
2020 Vol. 27 (17): 145-147 [
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63
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Application effect of Sufentanil combined with Ropivacaine for epidural anesthesia with step analgesia in prim ipara
YE Xiu-li； LI Li-qian
Objective
To investigate the clinical effect of Sufentanil combined with Ropivacaine for epidural anesthesia with step analgesia.
Methods
From January 2017 to January 2019,120full-term singleton primiparas delivered in our hospitalwere selected and randomly divided into observation group(n=60)and control group(n=60).The control group was routinely given Sufentanil+Ropivacaine,while the observation group was given Sufentanil+Ropivacaine in stages according to the dilatation of uterine orifice.The visual analogue scale(VAS),duration of labor,lower limbmotor nerve inhibition and Apgar score of newborn were compared between the two groups.
Results
There were no significant difference in VASscore and Apgar score between the two groups(P＞0.05).The Bromage score in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The incubation period of labor in the observation group was shorter than that in the control group,and the difference was statistically significant(P＜0.05).
Conclusion
Sufentanil+Ropivacaine has a good analgesic effect for staged labor,compared with conventional analgesicmethods,this analgesic method has a lower degree of inhibition onmaternal lower limb motor function and is worthy ofwide clinical application.
2020 Vol. 27 (17): 148-150 [
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63
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Effect of target controlled infusion of Rem ifentanil combined with Propofol target-controlled infusion on maintenance anesthesia in children undergoing tonsillectom y
XIAO Jun-wei； ZHAI Yu-jia； GU Hui
Objective
To investigate the effect of Remifentanil combined with Propofol target-controlled infusion on maintenance anesthesia in children with tonsillectomy.
Methods
A total of 120children who were planned to undergo tonsillectomy in our hospital from January 1,2016to June 30,2019 were selected and divided into control group and experimental group according to random number tablemethod,with 60 children in each group.The control group was given Propofol and Fentanyl induced anesthesia,and anesthesia wasmaintained by inhalation of Isoflurane.The experimental group was given Remifentanil combined with Propofol target-controlled infusion to maintain anesthesia.The hemodynamic parameters (mean arterial pressure,heart rate,blood oxygen saturation)parameters,extubation time,spontaneous breathing recovery time,wake time and the total incidence of complication were compared.
Results
The mean arterial pressure,heart rate and blood oxygen saturation of the two groups were compared,and the differences were not statistically significant(P＞0.05).Themean arterial pressure and heart rate in the experimental group 1min after intubation,excision,and extubation were lower than those in the control group,and the differenceswere statistically significant(P＜0.05).The extubation time,spontaneous breathing recovery time,and wake-up time in the experimental group were shorter than those in the control group,with statistical differences significance(P＜0.05).There were no significant differences in blood oxygen saturation between the two groups of patients at 1min after intubation,at the time of resection,at the time of extubation,and at consciousness(P＞0.05).The total incidence of complications in the experimental group(8.34%)was lower than the control group(25.00%),and the difference was statistically significant(P＜0.05).
Conclusion
Remifentanil combined with Propofol target-controlled infusion on maintenance anesthesia can maintain stable hemodynamics during perioperative period in children with tonsillectomy,shortened wake-up time,fewer complications and has a good anesthetic effect.
2020 Vol. 27 (17): 151-153转166 [
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66
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Application effect of Xuanyu Tongjing Decoction combined with gonadotropin-releasing hormone agonist in the postoperative patients with ovarian endometriosis
WANG Shuang； AI Xiao-yan； YUAN Yuan； MEI Tong； XIONG Xiang-peng
Objective
To investigate the application effect of Xuanyu Tongjing Decoction combined with gonadotropinreleasing hormone agonist(GnRH-a)in the postoperative patientswith ovarian endometriosis.
Methods
From January 2017 to January 2019,100 patients with ovarian endometriosis (stageⅢ-Ⅳ)treated by laparoscopic surgery in our hospital were selected as the research objects,and they were divided into observation group (50 cases)and control group(50 cases)according to the random number tablemethod.The patients in the control group were treated with Leuprolide,and the patients in the observation group were treated with Xuanyu Tongjing Decoction based on the control group.The clinical efficacy,sex hormones(estradiol[E
2
],luteinizing hormone[LH],follicle stimulating hormone[FSH])levels,symptom scores of traditional Chinesemedicine,dysmenorrhea score before and after treatment and incidence of adverse reactions were compared.
Results
The total effective rate of the observation group after treatment was higher than that of the control group,and the total incidence rate of adverse reactionswas lower than that of the control group,with statistically significant differences(P＜0.05).The traditional Chinesemedicine symptom score,dysmenorrhea score and sex hormone levels after treatment of the observation group were lower than those of the control group,and the differences were statistically significant(P＜0.05).
Conclusion
Xuanyu Tongjing Decoction combined with GnRH-a for postoperative patients with ovarian endometriosis can improve clinical efficacy,reduce traditional Chinese medicine syndrome score and pain score,improve sex hormone levels,and reduce the adverse reactions caused by long-term single administration of GnRH-a drugs,with better therapeutic effect.
2020 Vol. 27 (17): 154-157 [
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58
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Effect of Dachengqi Decoction combined with continuous renal replacement therapy on severe acute pancreatitis
ZENG Shu-chun; MA Yi; ZHANG Cui-xian
Objective
To explore the effect of Dachengqi Decoction combined with continuous renal replacement therapy (CRRT)on severe acute pancreatitis (SAP).
Methods
A total of 72SAP patients who were treated in our hospital from January 2017 to September 2019 were selected as subjects,and they were divided into study group and control group according to the random number table method,36cases in each group.The control group was given routine treatment,and the study group was given Dachengqi Decoction combined with CRRT on the basis of the control group.The levels of inflammatory factors(tumor necrosis factor-α[TNF-α],interleukin-6[IL-6],procalcitonin[PCT],high-sensitivity C-reactive protein[hs-CRP]),renal function(blood urea nitrogen[BUN],serum creatinine[SCr])and acute physiology and chronic health evaluation(APACHEⅡ)score before treatment and after 72hours treatmentwere compared between the two groups.The disappearance time of clinical symptoms (abdominal discomfort disappearance time,body temperature recovery time,intestinal peristalsis recovery time,blood amylase recovery time)was compared between the two groups after treatment.
Results
After 72hours of treatment,the levels of TNF-α,IL-6,PCT,hs-CRP,BUN,SCr and APACHEⅡscores in the two groups were lower than those before treatment,and those in the study group were lower than those in the control group,with statistically significant differences (P＜0.05).The abdominal discomfort disappearance time,body temperature recovery time,intestinal peristalsis recovery time,blood amylase recovery time in the study group were shorter than those in the control group,and the differences were statistically significant(P＜0.05).
Conclusion
Dachengqi Decoction combined with CRRT has a good effect on SAP,which can effectively reduce the levels of inflammatory factors,improve renal function,promote the recovery of gastrointestinal function and benefit the prognosis of patients.
2020 Vol. 27 (17): 158-161 [
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57
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Clinical effect of self-made Bushen Huoxue Zhuyun Decoction combined with warm acupuncture at Baliao acupoint in the treatment of occult primary ovarian insufficiency with infertility
XIANG Xi; HUANG Xiao-tao; GE Man; GAO Jing
Objective
To investigate the clinical effect of self-made Bushen Huoxue Zhuyun Decoction combined with warm acupuncture at Baliao acupoint in the treatment of occult primary ovarian insufficiency (POI)with infertility.
Methods
Sixty patients with occult POI combined with infertility who were treated in the Department of Integrated Traditional Chinese and Western Medicine of HubeiMaternal and Child Health Hospital from March 2017 to December 2018 were selected as the research objects,and they were divided into three groups according to the random alphabet:Letrozole group(group A),Letrozole+Complex Packing Estradiol Tablets/Estradioland Dydrogesterone Tablets(Fenmorphone)+Aspirin group(group B)and Letrozole+Dydrogesterone+Chinesemedicine+warm acupuncture group(group C),20cases in each group.Patients in group A simply used low-dose Letrozole to induce ovulation.Patients in group B were given Complex Packing Estradiol Tablets/Estradioland Dydrogesterone Tablets(white tablets)1to 2mg orally on the tenth day ofmenstruation on the basis of group A,and given Complex Packing Estradiol Tablets/Estradioland Dydrogesterone Tablets(gray tablets)1to 2tablets plus Aspirin Enteric-coated Tablets 25mg for oral administration at 72hours after ovulation.On the basis of group A,the patients in group C were given Chinese medicine self-made Bushen Huoxue Zhuyun Decoction on the fifth day of themenstrual cycle,combined with warm acupuncture at Baliao acupoint twice a week,and given Dydrogesterone Tablets orally 72hours after ovulation,1tabletat a time,twice a day.The treatment period was 6months,and the endometrial thickness,shape,spiral uterine artery blood flow parameters(pulse index [PI],resistance index [RI],peak systolic velocity/end diastolic peak velocity [S/D]),pregnancy rate and spontaneous abortion rate were counted among the three groups.
Results
The pregnancy rates in group B and group C were higher than those in group A,the differenceswere statistically significant(P＜0.05).There was no significant difference in the pregnancy rate between group B and group C (P＞0.05).There was no significant difference in spontaneous abortion rate among the three groups (P＞0.05).The endometrial thickness in group B and group C was higher than that in group A,with statistically significant differences(P＜0.05).There was no statistically significant difference in endometrial thickness between group B and group C (P＞0.05).The proportion of endometrium A in group C was higher than that in group A and group B,with statistically significant differences(P＜0.05).There was no statistically significant difference in the proportion of endometrium A between group A and group B (P＞0.05).The PIof group B and group C was lower than that of group A,with statistically significant differences(P＜0.05).There was no statistically significant difference in PIbetween group B and group C(P＞0.05).The RIand S/D in group B and group C were lower than those in group A,and those in group C were lower than those in group B,with statistically significant differences(P＜0.05).
Conclusion
The combination of Chinese medicine and acupuncture can definitely improve the endometrial thickness and uterine artery blood flow parameters,and can increase the clinical pregnancy rate of patientswith occult POIwith infertility.
2020 Vol. 27 (17): 162-166 [
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53
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Application value of serum free estriol and creatinine combined in fullterm pregnancy detection
XU Fu-ping; ZHANG Dong-wu; CHEN Hui-min; ZHONG Jian-wen; JIANG Xiao-sheng
Objective
To explore the value of serum free estriol(FE
3
)and creatinine(Cr)in full-term pregnancy detection.
Methods
From January 2017 to December 2018,60 pregnantwomen in this area were selected as the research objects.The target group was divided into 37-week group,38-week group,39-week group and 40-week group according to gestational age.FE
3
,Cr,B-mode ultrasound were used to diagnose the placentalmaturity of full-term pregnant women.Based on B-mode ultrasound data and clinical data,ROC curves were performed according to each data,the diagnostic value of FE
3
/Cr for placental maturity was evaluated.
Results
With the prolongation of gestational weeks,FE
3
,Cr and FE
3
/Cr increased,the difference was statistically significant(P＜0.05).The placentalmaturity of 38-week group was better than that of 37-week group,37-week group was better than that of 37-38-week group,and 40-week group was better than that of 37-39-week group(P＜0.05).The area under the ROC curve(AUC)of FE
3
/Cr in the diagnosis of placentalmaturity was 0.823,the optimal threshold was 11.02,the sensitivity was 70.69%,and the specificity was 88.01%.
Conclusion
Based on the analysis of ROC curve,it is suggested that the ratio of FE
3
/Cr＞11.02can be used to diagnose the low maturity of placenta.The determination of serum free estriol and creatinine has significant significance in the full-term detection of pregnancy.It is speculated that comprehensive detection has certain clinical significance in the diagnosis of placentalmaturity.
2020 Vol. 27 (17): 167-169 [
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63
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170
Analysis of IgM antibody test results of 9 pathogens in patients with respiratory tract infections in our hospital from 2013 to 2018
YE Li-hong; CHEN Xiao-kai
Objective
To analyze the distribution of respiratory tract infection pathogens and provide evidence for the treatment of respiratory tract infection.
Methods
The blood samples of patients with respiratory tract infection in the First Peopole′s Hospital of Huizhou from 2013 to 2018 were detected by indirect immunofluorescence (IFA),and the distribution difference of 9 respiratory pathogens in age and season was analyzed.
Results
The total positive rate of IgM antibody among 9 pathogens in 13345patientswas 42.17%,and the top three pathogens in IgM antibody positive rate were Mycoplasma pneumoniae(31.17%),Influenza B virus(13.38%)and Parainfluenza virus(7.78%).The positive rates of IgM antibody to Mycoplasma pneumoniae and Influenza B virus in the juvenile group were higher than those in the elderly group.The positive rate of IgM antibody of Influenza virus was higher in spring and winter,while that of Legionella pneumophila was higher in autumn and winter.However,there was no significant seasonal difference in the IgM antibody positive rate of Mycoplasma pneumoniae.
Conclusion
The pathogens of respiratory tract infection were related to age and season,but Mycoplasma pneumoniae and Influenza B virus were still themost important pathogens of all ages and seasons.
2020 Vol. 27 (17): 170-172 [
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56
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Application of combined test of serum C-peptide,glycosylated hemoglobin and N-acetylβ-D-glucosidase in the diagnosis of early renal injury of type 2diabetesmellitus
ZHONG Xiao-xiong
Objective
To investigate the application of combined test of serum C peptide,glycosylated hemoglobin and N-acetylβ-D-glucosidase in the diagnosis of early renal injury in type 2diabetesmellitus.
Methods
A total of 50 patientswith early renal injury of type 2diabetesmellitus treated in our hospital from January 2018 to June 2019 were selected as the study group.Another 50 patientswith type 2diabetesmellitus treated in our hospital in the same period of time were selected as the control group 1.In addition,50 volunteers who came to the hospital for routine physical examination in the same time period were selected as the control group 2.All the three groupswere diagnosed by combined test of serum C-peptide,glycosylated hemoglobin and N-acetylβ-D-glucosidase,and the resultswere compared and analyzed.
Results
The course of diabetes in the study group was longer than that in the control group 1,and the differencewas statistically significant(P＜0.05).The levels of fasting blood glucose and urinarymicroalbumin to creatinine in the study group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The levels of glycosylated hemoglobin and N-acetylβ-D-glucosidase in the study group were higher than those in the control group 1and control group 2,and the differenceswere statistically significant(P＜0.05).The levels of serum C-peptide in the study group was lower than that in the control group 1and control group 2,the difference was statistically significant(P＜0.05).The levels of fasting blood glucose and urinarymicroalbumin/creatine ratio in the control group 1were higher than those in the control group 2,and the differenceswere statistically significant(P＜0.05).The levels of of hemoglobin,N-acetylβ-D-glucosidase in the control group 1were higher than those of the control group 2,and the difference was statistically significant(P＜0.05).The level of serum C-peptide in the control group 1was lower than that in control group 2,and the difference was statistically significant(P＜0.05).
Conclusion
The combined test of serum C-peptide,glycosylated hemoglobin and N-acetylβ-D-glucosidase can play an effective role in the diagnosis of early diabetic renal injury.It can provide an accurate reference for the diagnosis of diabetesmellitus,and has important application value.
2020 Vol. 27 (17): 173-175转179 [
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62
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Research on the dilemma and countermeasure of the integration of the elderly hospice care into the community in Changchun
LIN Fu； LIXin； ZHANG Min； LI Lu； LENG Yue； ZHANG Rui
Objective
To understand the cognition of community medical personnel and residents in Changchun on hospice care for elderly patients,and explore its development dilemma,so as to provide a strong basis for the clinical work of community hospitals to carry out hospice care projects.
Methods
A total of 207 people (53medical staff and 154residents)were surveyed from 4community hospitals and 2communities in Changchun from October 2018 to April 2019 by convenient sampling method.
Results
The qualified rate ofmedical personnel with doctor′s degree was not significantly different from that ofmaster′s degree (P＞0.05).The qualified rate ofmedical personnelwithmaster′s degree and doctor′s degree was higher than that of technical secondary school,junior college and undergraduate,and the differences were statistically significant(P＜0.05).The qualified rate of undergraduate medical personnel was higher than that of technical secondary school and junior college,and the differences were statistically significant(P＜0.05).The qualified rate of collegemedical personnel was higher than that of technical secondary school,and the difference was statistically significant(P＜0.05).There was no significant difference in the qualified rate of the cognition of hospice care among themedical staff of different positions (P＞0.05).The cognition total score of the 150 community residents on hospice care was(71.43±13.94)points.
Conclusion
In Changchun,the level of cognition about hospice care ofmedical staff is not uniform,the overall level is low,the community residents do not know enough about hospice care services,and there is no positive understanding.The relevant organizations should focus on strengthening the education of the two,and improve their cognitive ability of hospice care.
2020 Vol. 27 (17): 176-179 [
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55
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Nosocom ial infection characteristics and risk factors analysis of orthopedic inpatients
KANG Zhong-qin； WU Xiao-ying
Objective
To analyze the clinical characteristics and risk factors of nosocomial infection in hospitalized patients in orthopedic department,so as to provide scientific basis for reducing the incidence of nosocomial infection in orthopedic.
Methods
A total of 3542patientswho hospitalized in the orthopedic department from September 1,2017 to August 31,2018 in our hospital were selected as themonitoring objects and divided into three specialized groups:the trauma group(1295cases),the joint group(1075cases)and the spine group(1172cases).The clinical characteristics and risk factors of nosocomial infection in orthopedic inpatientswere analyzed.
Results
The incidence rate of nosocomial infection of orthopedic inpatientswas 1.67% (the case number infection ratewas 1.89%).The incidence rate of case number nosocomial infection in the trauma group was 2.93%,which was higher than that in the joint group(1.58%)and spine group(1.02%),the differenceswere statistically significant(P＜0.05).The top three infection siteswere lower respiratory tract(32.84%),surgical site(31.34%)and urinary tract(20.90%).Gram-negative bacteria,gram-positive bacteria and fungi accounted for 50.00%,46.00%,and 4.00%,respectively.The top three pathogens were Staphylococcus aureus(24.00%),Escherichia coli(20.00%)and Acinetobacter baumannii(12.00%).The differences between the infected and uninfected patients in age(over 65years old),gender,hypoproteinemia,basic diseases(more than 2kinds),traction brake,surgery,use of ventilator,admission to ICU,central vein catheterization and indwelling catheter were statistically significant(P＜0.05).Furthermultivariate unconditional Logistic regression analysis showed thatmale,hypoproteinemia,basic diseases (more than 2kinds),admission to ICU,central vein catheterization and indwelling catheter were independent risk factors of nosocomial infection in orthopedic patients(P＜0.05).
Conclusion
The nosocomial infection of orthopedic inpatients has the following characteristics:themainly infection sites are lower respiratory tract and surgical site,the proportion of gramnegative bacteria and gram-positive bacteria is similar,and the nosocomial infection rate in trauma patients is higher.The risk of nosocomial infection of orthopedic inpatients with one ormore of the above risk factors is higher.The hypoproteinemia and basic diseases should be actively treated,and invasive operation should be standardized and reduced,in order to reduce the nosocomial infection rate.
2020 Vol. 27 (17): 180-183 [
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63
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Comments and analysis of 1268 pieces of prescriptions of Chinese herbal pieces in outpatient department of our hospital
LI Xin
Objective
To understand the irrational use of Chinese herbal pieces and improve the rationality of clinical medication by comments and analysis of the recent prescriptions of Chinese herbal pieces in outpatient department of our hospital.
Methods
From September 2019 to February 2020,about 200 pieces of outpatient prescriptions of Chinese herbal pieceswere randomly extracted in the traditional Chinesemedicine pharmacy of Guangzhou First People′s Hospital everymonth.According to Prescription Administrative Method,Prescription of Traditional Chinese Medicine Format and Writing Norms,and Hospital Prescription Comments Management Norms (Trial),the prescriptions were commented and analyzed.
Results
The irrational use rate of the outpatient prescription of Chinese herbal pieces of our hospital was 25.07%.Excessively using toxic/small toxic Chinesemdicine and unspecified special decoction requirementswere themain problems.
Conclusion
Clinicians,pharmacists andmanagement departments should implement the prescription comment system and supervision simultaneously,which is helpful to standardize the prescription of Chinese herbal pieces and ensure the rationality of clinicalmedication.
2020 Vol. 27 (17): 184-187 [
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62
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Application of caring management system in the management of closed wards of psychiatric department
WAN Yue-hui
Objective
To explore the application effect of caring management system in the management of closed wards of psychiatric department.
Methods
A total of 120patients with depression from January 2015to December 2018 in our hospitalwere selected into this study.They were divided into observation group and control group by random number tablemethod,60 cases in each group.Patients in the control group received conventional nursing,and in the observation group,they received humanistic care.The negative emotion scores,total nursing satisfaction and quality of life of the two groups of patients after nursing were analyzed.
Results
After nursing,the negative emotion scores of the two groups of patientswere lower than those before the nursing,and the differenceswere statistically significant(P＜0.05).The negative emotion score of the observation group after nursing was lower than that of the control group,and the difference was statistically significant(P＜0.05).The total nursing satisfaction of the observation group was higher than that of the control group,with statistical significance (P＜0.05).The quality of life scores after 1,2,and 3months of nursing of the two groupswere higher than those before nursing,and the differenceswere statistically significant(P＜0.05).The life quality scores after 1,2,and 3months of nursing in the observation group were higher than those of the control group,and the differenceswere statistically significant(P＜0.05).
Conclusion
Intervening the closed wardmanagement of psychiatric patients by adopting humanistic caremanagement is conducive to improving patients′physical and mental health,enhancing their comfort and improving their nursing satisfaction.
2020 Vol. 27 (17): 188-190转194 [
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65
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Application of quality management tools in reducing the incidence of falls in inpatients
LIU Shao-yan
Objective
To explore the application value of qualitymanagement tools in reducing the incidence of falls in inpatients.
Methods
From January to December 2017,1550 inpatients in respiratory medicine were selected as the subjects of study (before implementation group),and nomanagement had been implemented.And 1930 inpatients in respiratorymedicine from January to December 2018 were selected as the subjects of study(after implementation group),and qualitymanagement toolswere given.And the incidence of falls,patients′total satisfaction,fall quality(the correct rate of fall risk assessment in hospital,the rate of fall prevention nursing reaching the standard)between the two groups were observed and evaluated.And the fall injury degree and severity assessment code(SAC)of adverse events of fall patients in the two groupswere compared.
Results
The incidence of falls in the after implementation group was lower than that in the before implementation group,and the difference was statistically significant(P＜0.05).The total satisfaction of patients in the after implementation group was higher than that in the before implementation group,and the difference was statistically significant(P＜0.05).The correct rate of fall risk assessment in hospital and the rate of fall prevention nursing reaching the standard of fall-prevention nursing in patients in the after implementation group were higher than those in thebefore implementation group,and the differenceswere statistically significant(P＜0.05).Therewere no significant differences in the degree of fall injury and SAC grading of fall patients between the two groups(P＞0.05).
Conclusion
The application of qualitymanagement tools in inpatients is beneficial to reduce the incidence of falls and has a positive effecton improving the satisfaction of patients.It isworthy of clinical application and promotion.
2020 Vol. 27 (17): 191-194 [
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72
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Application of nurses′hierarchical management mode in patients with acute severe hepatitis and nursing staff
DENG Chun-tao； YUAN Qiu-ying； ZHONG Chun-mei
Objective
To explore the effect of nurses′hierarchicalmanagementmode in nursing staff and patientswith acute severe hepatitis.
Methods
A total of 82patientswith acute severe hepatitis from March 2018 to September 2019 and 31nursing staffwere selected as research objects,and they were divided into the observation group and the control group by random number tablemethod.The observation group included 41patients and 15nurses which were applied to nurses′hierarchicalmanagementmode.The control group included 41patients and 16nurseswhich were applied to routine nursing mode.The quality of nursing managementmode and patients′overall satisfaction were compared between two groups.
Results
The scores of nursing quality of the observation group were higher than those of the control group,and the differencea were statistically significant(P＜0.05).Patients′overall satisfaction in the observation group(97.56%)was higher than that in the control group (80.49%),and the differencewas statistically significant(P＜0.05).
Conclusion
Nurses′hierarchicalmanagementmode nursing can significantly improve the quality of nursing management and patients′satisfaction.
2020 Vol. 27 (17): 195-197转207 [
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Application effect of com prehensive psychological intervention in cervical cancer patients
CHEN Jin-xuan; XIA Ling-ling; WANG Hong-yan
Objective
To explore the application effect of comprehensive psychological intervention in cervical cancer patients.
Methods
From April 2018 to November 2019,60 patients with cervical cancer who were received radical surgery in our hospital were selected as the research objects,they were divided into the experimental group and the control group according to random number tablemethod,30 cases in each group.The control group was given conventional radical operation of cervical cancer,and the experimental group was given comprehensive psychological intervention on the basis of the control group.The scores of Herth hope scale and resilience scale(CDRISC)were compared between the two groups.
Results
The Herth score of the two groups after nursing was better than that before nursing,the difference was statistically significant(P＜0.05).The Herth score of the experimental group after nursing was better than that of the control group,the differencewas statistically significant(P＜0.05).The scores of optimism,tenacity,strength and the total scores of RISC in the two groups after nursing were higher than those before nursing,the total scores of optimism,tenacity,strength and the total scores of RISC in the experimental group after nursing were higher than those in the control group,the differences were statistically significant(P＜0.05).
Conclusion
Comprehensive psychological intervention can effectively improve the hope level of cervical cancer patients,enhance the level of psychological flexibility of patients,and can be popularized in clinical practice.
2020 Vol. 27 (17): 198-200 [
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Application of special management in preventing falls in patients with stroke
XIANG Jiao； WU Ming-xiu
Objective
To investigate the application of specialmanagement in preventing falls in patients with stroke(CVA).
Methods
A total of 126CVA patients admitted to our hospital from August 2018 to February 2019 were selected as the research subjects,and divided into control group(n=64)and observation group(n=62)according to the random number tablemethod.The control group received routine care,and the observation group received specialmanagement based on the control group.The fall prevention awareness and risk of falls between the two groups before intervention,1month after discharge,and 6months after discharge were compared,the total incidence of falls from before intervention to 6months after discharge between the two groupswere compared.
Results
There were no significant differences in the fall prevention awareness and the risk of falls between the two groups of patients before the intervention (P＞0.05).At 1and 6months after discharge,the fall prevention awareness in the observation group was higher than that in the control group,and the risk of falls was lower than that in the control group,and the differences were statistically significant(P＜0.05).The total incidence of falls from before intervention to 6months after discharge in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).
Conclusion
Specialmanagement can improve patients′fall prevention awareness,reduce the risk of falls,and reduce the incidence of falls.
2020 Vol. 27 (17): 201-203转211 [
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Application of permanent pacemaker im p lantation in patients with chronic arrhythm ia
HUANG Shu-zhen； XU Juan
Objective
To explore the application of special nursing care of permanent pacemaker implantation in patients with chronic arrhythmia.
Methods
From November 2016to August 2019,90 patients with chronic arrhythmia treated by permanent pacemaker implantation were selected as study subjects.They were divided into observation group(n=45)and control group(n=45)by the random digital tablemethod.The patients in the control group were treated with routine nursing after operation,while the observation group was treated with permanent pacemaker implantation on the basis of the control group.The incidence of complications after permanent pacemaker implantation was compared between the two groups,the quality of life and discharge time of the two groupswere compared,and the nursing satisfaction of the two groups was counted.
Results
The total incidence of complications in the observation group was lower than that of the control group,with statistical difference(P＜0.05).The quality of life scale(SF-36)scores of the observation group was higher than that of the control group,and the hospitalization time was shorter than that of the control group,with statistical differences(P＜0.05).The nursing total satisfaction of the observation group washigher than thatof the controlgroup,with statisticaldifference(P＜0.05).
Conclusion
After permanentpacemaker implantation,there aremany kinds of related complications and various causes in patientswith chronic arrhythmias.The postoperative special nursing can effectively reduce the occurrence probability of the postoperative complications of the patients,is beneficial to the postoperative rehabilitation of the patients,improves the quality of life and improves the nursing satisfaction degree.
2020 Vol. 27 (17): 204-207 [
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Influence of cooperative nursing intervention on negative emotion,hip joint function and quality of life of elderly patients after total hip rep lacement
XIAO Li-ping
Objective
To explore the influence of cooperative nursing intervention on negative emotion,hip joint function and quality of life of elderly patients after total hip replacement(THA).
Methods
From March 2018 to March 2019,60 elderly patientswho underwent THA in our hospitalwere selected as the study objects,and they were divided into the control group and the intervention group by the random number tablemethod,30 cases in each group.The patients in the control group were given routine nursing,and the patients in the intervention group were given cooperative nursing intervention on the basis of the control group.The depression,anxiety scores,hip joint function scores and quality of life scoreswere compared between the two groups at 1,3and 6months after intervention.
Results
The scores of depression and anxiety in the two groups at 1,3and 6months after intervention were lower than those before intervention,with statistical differences(P＜0.05).The scores of depression and anxiety in the two groups at3and 6months after intervention were lower than those at 1month after intervention,with statistical differences(P＜0.05).The scores of depression and anxiety in the two groups at 6months after intervention were lower than those at 3months after intervention,with statistical differences(P＜0.05).The scores of depression and anxiety in the observation group at 1,3and 6months after intervention were lower than those in the control group,with statistical differences(P＜0.05).The Harris hip joint function score and SF-36score of the two groups at 3and 6months after intervention were higher than those at 1month after intervention,with statistical differences(P＜0.05).The Harris hip joint function score and SF-36score in the two groups at 6months after intervention were higher than those at 3months after intervention,with statistical differences(P＜0.05).The SF-36score of the two groups at 1,3and 6months after intervention were higher than those before intervention,with statistical differences(P＜0.05).The Harris hip joint function score and SF-36score in the observation group at 1,3and 6months after intervention were higher than those in the control group,with statistical differences(P＜0.05).
Conclusion
Cooperative nursing intervention can significantly improve the negative emotions,hip joint function and quality of life of the elderly patients after THA,which isworthy of clinical promotion and application.
2020 Vol. 27 (17): 208-211 [
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Effect of com p liance guidance on patients with femoral fracture
WEN Wu-mei； HUANG Lin； HUANG Wei-hua
Objective
To explore the effect of compliance guidance on patients with femoral fracture.
Methods
Sixty patientswith femoral fracture admitted to Ji′an First People′s Hospital from January 2017 to January 2019 were selected and divided into control group(n=30)and experimental group(n=30)according to random number tablemethod.The compliance of the two groups before and after nursing(according to the requirements to complete the exercise frequently,according to the correct trainingmethod to complete the exercise,according to the type of training to complete the exercise,according to the training type)were analyzed.Training time to complete exercise score,Lysholms score,visual simulation score,complications (pulmonary infection,deep venous thrombosis,pressure sore,constipation and joint stiffness,etc.),satisfaction and other related indicators were compared between two groups.
Results
There was no significant difference in compliance score between the two groups before nursing,according to the requirements,according to the correct trainingmethod,according to the type of training,and according to the training time(P＞0.05).After nursing,the patients in the experimental group completed the exercise frequently according to the requirements,completed the exercise according to the correct training method,and finished the exercise according to the training type,the scores of Lysholms in the experimental group were higher than those in the control group,with statistical differences(P＜0.05).The visual analogue score of the femoral fracture in the experimental group and the total complication rate of pulmonary infection,deep vein thrombosis,pressure sore,constipation and joint stiffness were lower than those of the control group with statistical differences(P＜0.05).
Conclusion
Compliance guidance can significantly improve the compliance score of early rehabilitation nursing in patientswith femoral fracture,and Lysholms score,satisfaction score,reduce the incidence of complications and visual simulation score.
2020 Vol. 27 (17): 212-214转218 [
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Application of targeted nursing intervention in silver acupuncture treatment of qi stagnation and blood stasis type low back pain
SONG Ling-ling； LIANG Hui； LIN Ru-xia； QIU Jia-wen
Objective
To explore the application effect of targeted nursing intervention in the treatment of low back pain caused by qi stagnation and blood stasis with silver needle.
Methods
From June 2018 to May 2019,60 patients with low back pain with qi stagnation and blood stasis treated with silver needlewere selected as the research subjects.They were divided into control group(n=30)and experimental group(n=30)by themethod of random digital table.The control group was given routine nursing intervention,while the experimental group was given targeted nursing intervention.After 4weeks,the curative effect of the two groups was compared,and the changes of lumbar vertebrae function score,visual pain simulation score (VAS)score,self-rating depression scale (SAS)score and self-rating anxiety scale(SDS)score were compared between the two groups.
Results
Before nursing,there were no significant differences in the scores of lumbar function,VAS pain,SASand SDSbetween the two groups(P＞0.05).After nursing,the scores of lumbar vertebrae function in the experimental group were higher than those in the control group,and the scores of VAS pain,SAS and SDSwere lower than those in the control group,the differences were statistically significant(P＜0.05).The total effective rate of the experimental group was higher than that of the control group,the difference was statistically significant(P＜0.05).
Conclusion
Targeted nursing intervention has a significant effect on the efficacy of silver acupuncture in the treatment of low back pain caused by qi stagnation and blood stasis.Targeted nursing is beneficial to the recovery of lumbar vertebrae function,relief of pain,relief of anxiety,depression and other negative emotions,which is beneficial to the improvementof the patients′condition.
2020 Vol. 27 (17): 215-218 [
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Application effect of team cooperation com fortable nursing mode in patients with laparoscopicm yomectom y
Liang Yan-ping
Objective
To explore the application effect of team cooperation comfortable nursingmode in patients with laparoscopic myomectomy.
Methods
A total of 60 patients with uterine fibroids admitted to our hospital from October 2017 to October 2018 were selected as the study subjects,and were divided into the control group (n=30)and the observation group (n=30)according to the random number table method.The observation group was treated with team work comfort nursingmethod,while the control group was treated with routine nursingmethod.The incidence of postoperative complications,summary of quality of lifemeasurement scale(WHO QOL-BREF),operation and length of stay were compared between the two groups.
Results
There was no significant difference in who WHO QOL-BREF score between the two groups before intervention(P＞0.05).TheWHO QOL-BREF scores of the two groups after intervention were higher than those before intervention,and theWHO QOL-BREF score of the observation group after intervention was higher than that of the control group,with statistical differences(P＜0.05).The total incidence of postoperative complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The operation time,postoperative anal exhaust time,postoperative bed time and hospital stay in the observation group were shorter than those in the control group,with statistical differences(P＜0.05).The amount of intraoperative blood loss in the observation group was less than that in the control group,and the difference was statistically significant(P＜0.05).
Conclusion
Themodel of team cooperation and comfortable nursing has a significant effect in patientswith laparoscopicmyomectomy,which can reduce the incidence of postoperative complications,improve the quality of life,reduce postoperative pain and shorten the operation time.It isworth clinical promoting.
2020 Vol. 27 (17): 219-221 [
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Application of evidence-based nursing in postoperative care of patients with lumbar fractures
WEN Hui-jun； CAO Ju-hong
Objective
To analyze the value of evidence-based nursing intervention in postoperative nursing of patients with lumbar fractures.
Methods
From January to December 2018,a retrospective analysiswas performed on 88 patients with lumbar fractures treated in our hospital,according to different nursing methods,they were divided into control group and study group,44cases in each group.The control group was provided with routine nursing,the study group was provided evidence-based nursing.The total nursing satisfaction,the total incidence of complications,emotional state and quality of lifewere compared between the two groups.
Results
The total nursing satisfaction of patients in the study group was 95.55%,higher than that of the control group accounting for 79.55%,the total incidence of complicationswas 9.09%,lower than that of the control group of 27.27%,with statistical differences (P＜0.05).The self-rating anxiety scale(SAS),self-rating depression scale(SDS)and visual analogue scale(VAS)scores in the study group were lower than those of the control group,and the quality of life assessment scale(SF-36)score was higher than that of the control group,and the differenceswere statistically significant(P＜0.05).
Conclusion
Evidence-based nursing intervention can effectively improve postoperative pain,mood,complications and satisfaction of patientswith lumbar fractures.
2020 Vol. 27 (17): 222-224 [
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Application of psychological nursing in patients with thyroid cancer
FAN Yi-song； CHEN Ya； DENG Jiang-bo； CHEN Xiong-fen； WU Guo-hai
Objective
To explore the application of psychologicalnursing in patients with thyroid cancer.
Methods
A total of 60 patients with thyroid cancer admitted to our hospital from January 2018 to June 2019 were selected,and they were divided into the control group and the study group according to random number tablemethod,30 cases in each group.The control group was implemented routine nursing,and the study group was implemented psychological nursing.The anxiety and depression score of the two groups before and after nursing were observed,total compliance of treatment and the total nursing satisfaction of the two groupswere compared.
Results
There was no significant difference in anxiety and depression score between the two groups before nursing (P＞0.05).The scores of anxiety and depression in the two groups after nursing were lower than those before nursing,the scores of anxiety and depression in the study group after nursing were lower than those in the control group,the differences were statistically significant(P＜0.05).Total compliance of treatment of the study group was higher than that of the control group,the difference was statistically significant(P＜0.05).The total satisfaction degree of the study group was 96.67%,which was higher than that of the control group(70.00%),the difference was statistically significant(P＜0.05).
Conclusion
Applying psychological nursing to patientswith thyroid cancer can improve their anxiety and depression,and improve their nursing satisfaction.
2020 Vol. 27 (17): 225-227 [
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Effect of WeChat continuous nursing on self-care ability and healthy behavior of peritoneal dialysis patients
PENG Fu-nan； LIU Qiong； HUANG Jie
Objective
To investigate the effectofWeChat-based continuous care on self-care ability and healthy behavior of peritoneal dialysis(PD)patients.
Methods
A total of 90 PD patients admitted to our hospital from January 2013to June 2018 were selected as the study subjects,and were divided into observation group (n=45)and control group (n=45)according to the random double-blind method.The control group was followed up by routine telephone after discharge,and the observation group was given WeChat type continuous nursing.Self-care ability and healthy behavior between the two groups were compared.
Results
After 6months of intervention,the ESCA scores of health knowledge level,self-care skills,self-care responsibility,and self-concept in the observation group were (40.86±3.25),(31.57±4.15),(24.03±4.14),(25.35±2.97)points,whichwerehigherthanthoseinthecontrolgroupfor(31.26±4.02),(27.54±5.25),(19.02±5.01),(22.15±5.11)points,the differences were statistically significant(P＜0.05).After 12months of intervention,the ESCA scores of the observation group were(43.84±2.97),(35.12±3.56),(27.18±2.84),(28.27±2.02)points,which were higher than those of the control group for(34.74±2.89),(31.25±4.86),(21.64±4.16),(24.15±2.68)points,the differenceswere statistically significant(P＜0.05).The HPLP scores of the observation group after 6and 12months of intervention were(101.36±4.5)and(129.54±4.12)points,which were higher than those of the control group for(89.15±7.21)and (102.74±4.62)points,the differences were statistically significant(P＜0.05).
Conclusion
It is beneficial to improving the health behavior,improve the self-care ability and benefit the outcome of the patients.
2020 Vol. 27 (17): 228-230 [
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Application effect of clinical nursing pathway in patients with tuberculosis and hepatitis B
CAO Shui-ying； LIU Jin-feng； CHEN Li-rong ； LING Xiao-hui
Objective
To analyze the application effect of health education on clinical nursing pathway in patientswith tuberculosis combined with hepatitis B.
Methods
From July 2016to June 2019,150 patients with tuberculosis and hepatitis B who were treated in our hospital were selected as the research subjects.They were divided into control group(n=75)and study group(n=75)by a random number tablemethod.In the control group,routine health education was used,and in the study group,clinical nursing pathway health education was applied.The disease awareness rate,medication compliance,nursing satisfaction,and negative emotion scores were compared between the two groups.
Results
The disease awareness rate of the study group was higher than that of the control group,and the difference was statistically significant(P＜0.05).The totalmedication compliance of the study group was higher than that of the control group,and the difference was statistically significant(P＜0.05).The nursing total satisfaction in the study group was higher than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the anxiety score or depression score between the two groups before the nursing intervention(P＞0.05).The anxiety and depression scores of the study group after the nursing intervention were lower than those of the control group,with statistical differences (P＜0.05).
Conclusion
For patients with tuberculosis and hepatitis B,application of health education on clinical nursing pathways can improve patient′s awareness of the disease,enhance patients′medication compliance,increase patient′s nursing satisfaction,and improve their negative emotions.
2020 Vol. 27 (17): 231-233转237 [
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Application effect of perioperative standardization of nursing procedures in patients with surgically resected brain functional area gliomas under arousal
LIU Min-qi; LIU Qiu-qiu
Objective
To explore the effect of perioperative standardized nursing procedures on the cognitive ability and living ability of patients with surgically resected brain functional gliomas under arousal state.
Methods
A total of 71patients with gliomas underwent surgical removal of gliomas in the awake state in Xiangya Hospital from August 2017 to August 2019 were selected,from August 2017 to July 2018,35cases were used as the control group,and the routine nursing process was implemented.From August 2018 to August 2019,36cases were used as the observation group,and the perioperative standardized nursing processwas implemented.The incidence of epilepsy,chills,urinalysis,drymouth and other adverse reactions,the simplemental state score (MMSE),the daily living ability score(ADL),and the patients′satisfaction with nursing were compared between the two groups.
Results
Total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The MMSE and ADL scores of patients in the observation group at 6months after operation were higher than those in the control group,and the differences were statistically significant(P＜0.05).Patients in the observation group had higher total satisfaction with care than the control group,and the difference was statistically significant(P＜0.05).
Conclusion
The standardized perioperative nursing process can reduce the intraoperative adverse reactions of patients with gliomas resected in brain function area under arousal state,promote the recovery of nerve function,improve the patients′daily life ability and nursing satisfaction during hospitalization.
2020 Vol. 27 (17): 234-237 [
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Application effect of com prehensive nursing on patients with Parkinson′s disease
XU yan; ZHANG Huan; JU Lu-yu; WANG Shan-shan; ZHANG Jie; HE Ying
Objective
To explore the application effect of comprehensive nursing in patients with Parkinson′s disease(PD).
Methods
A total of 180 PD patients admitted to our hospital from March 2017 to February 2019 were selected as research objects,according to random number tablemethod,they were divided into observation group (n=90)and control group (n=90).Comprehensive nursingmethod was used for the observation group,the control group was used conventional nursingmethod.The quality of life,sports function of the two sets of scores and anxiety,depression and other psychological state were compared between two groups.
Results
The scores of psychological function,physical function,material life function and social function in the observation group were higher than those in the control group,with statistical differences(P＜0.05).The scores ofmanual ability,walking posture and language speed in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The scores of anxiety and depression in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).
Conclusion
Comprehensive nursing for PD can significantly improve the quality of life and motor function of patients，effectively relieve patients′anxiety,depression and other adverse emotions,it isworthy ofwide application and promotion in clinical practice.
2020 Vol. 27 (17): 238-240 [
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Application effect of nurse-patient communication skills in the elderly diabetes care
CHEN Li-bing; YAO Jin-mei; LIN Li-min
Objective
To explore the application effect of nurse-patient communication skills in the elderly diabetes care.
Methods
A total of 225elderly patients with diabetes in our hospital from January 2018 to June 2019 were selected as the study subjects.They were divided into two groups according to the random number tablemethod,112cases in the study group and 113cases in the control group.The patients in the control group were given routine clinical nursing program,while the patients in the study group were given routine nursing with nurse-patient communication.The satisfaction and compliance of the two groupswere compared.
Results
The total satisfaction of the study group was higher than that of the control group,with statistical difference (P＜0.05).The total compliance of the study group was higher than that of the control group,with statistical difference (P＜0.05).
Conclusion
The application of nurse-patient communication skills in the clinical care of elderly patients with diabetes can improve the patient′s care satisfaction and clinical care compliance,which isworthy ofwide application in nursing.
2020 Vol. 27 (17): 241-243 [
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69
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244
Application effect of continuous intervention nursing in patients with vertebral artery type of cervical spondylosis
LIU Ya-na; HAO Wei-wei; ZHANG Na; SUN Qiu-hong; LI Yue
Objective
To study the application effect of continuous nursing intervention in patientswith vertebral artery type of cervical spondylosis.
Methods
A total of 100 patientswith vertebral artery type of cervical spondylosis treated in our hospital from February 2017 to May 2019 were selected in this study.They were divided the reference group and the observation group according to random number tablemethod,50 cases in each group.In the reference group,conventional orthopedic intervention was used,and in the observation group continuous nursing intervention was used.After three-month observation,the treatment compliance,self-care ability and cervical dysfunction index change between the two groupswere compared.
Results
At3months after discharge,the scores in terms of diet,treatment,living habits,and medication in the observation group were higher than those in the reference group,and the differenceswere statistically significant(P＜0.05).In the observation group,the self-care ability score was lower than that of the reference group,and the differencewas statistically significant(P＜0.05).The cervical dysfunction index in the observation group was lower than that in the reference group,with statistical difference(P＜0.05).
Conclusion
In the nursing of vertebral artery type of cervical spondylosis,the selection of continuous intervention is conducive to improving patient′s treatment compliance and self-care ability,which is critical to the prognosis.
2020 Vol. 27 (17): 244-246 [
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63
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247
Application effect of body language communication in pediatric nursing
WANG Pei-fen; WANG Chun-yan; LI Fei-yan; PEI Yan-yan; YAN Qin
Objective
To analyze the application effect of body language communication in pediatric nursing.
Methods
From January 2018 to July 2019,150 patients treated in our hospitalwere selected as the research subjects.They were divided into control group and observation group according to the random number table method,75cases in each group.Patients in the control group received routine nursing.In the observation group,body language communication nursingwasused.The treatment total compliance,occurrenceofnursingadverseevents,and totalsatisfaction from patient′s parents on nursing were compared in the two groups.
Results
The treatment total compliance of children in the observation group was 92.00%,higher than that in the control group accounting for 72.00%,and the difference was statistically significant(P＜0.05).The obligatory treatment rate of children in the observation group was 4.00%,the rate of refusal to treat in crying children was 6.67%,the variation rate of treatment and nursing path was 4.00%,and the rate of exacerbation caused by inadequate care was 4.00%,the rate of nursing disputeswas 1.33%,which were all lower than those in the control group accounting for 18.67%,24.00%,16.00%,20.00%,and 14.67%,with statistical differences(P＜0.05).The total satisfaction from children′s parents in the observation group was 94.67%,higher than that in the control group accounting for 78.67%,and the difference was statistically significant(P＜0.05).
Conclusion
Body language communication has high clinical application value in pediatric nursing,which can improve children′s treatment compliance and reduce the risk of adverse events in nursing,increase the nursing satisfaction from children′s parents and obtain a remarkable effect.
2020 Vol. 27 (17): 247-249 [
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68
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250
Effect of psychological nursing combined with Sulfadiazine silver lipid water gel dressing on negative emotion and com p lications in patients after circum cision
LU Hua-qun; ZOU Hui-juan; HE Zhuo-bin
Objective
To investigate the effect of psychological nursing combined with Sulfadiazine silver lipid water gel dressing(excellent SSD)on negative emotion and complications in patients after circumcision.
Methods
Eighty-four patients undergoing circumcision from December 2017 to December 2018 were enrolled in the study.They were divided into two groups according to the different nursing methods,42cases in each group.The observation group was given psychological care combined with the excellent SSD,and the control group was given general nursing.The anxiety score,pain score and total complication rate of the two groupswere observed and evaluated.
Results
There was no significant difference in anxiety score between the two groups before intervention (P＞0.05).The anxiety scores of the observation group were lower than those of the control group after intervention,the difference was statistically significant(P＜0.05).There was no significant difference in the pain score between the two groups before intervention (P＞0.05).The pain score in the observation group was lower than that in the control group after intervention,the difference was statistically significant(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).
Conclusion
Psychological nursing combined with excellent SSD is beneficial to alleviate negating emotions and reducing the incidence of complications in patients after circumcision.It isworthy of clinical application and promotion.
2020 Vol. 27 (17): 250-252 [
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57
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