噻托溴铵联合布地奈德雾化吸入治疗慢性阻塞性肺疾病的临床效果

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (36 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the clinical effect of Tiotropium Bromide combined with Budesonide atomization inhalation in the treatment of chronic obstructive pulmonary disease.Methods A total of 96patients with chronic obstructive pulmonary disease who were treated in outpatient clinic of our hospital from October 2018 to October 2019 were selected as subjects.They were divided into observation group and control group based on double-blind method,48 cases in each group.All patients received basic treatment,the control group was treated with Tiotropium Bromide,and the observation group was combined with Budesonide atomization inhalation therapy based on the control group.The clinical efficacy and adverse reactions of the two groups were compared and analyzed.The changes of lung function,oxygenation index and blood gas index before and after treatment in the two groupswere studied.Results The total effective rate in the observation group was higher than that in the control group,the difference was statistically significant(P＜0.05).After 2weeks of treatment,the levels of forced expiratory volume(FVC),forced expiratory volume in the first second (FEV1),ratio of FEV1 to FVC (FEV1/FVC),oxygenation index,and arterial partial oxygen pressure(PaO2)in the observation group were higher than those in the control group,and partial pressure of carbon dioxide in artery (PaCO2)level was lower than that in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Tiotropium Bromide combined with Budesonide atomization inhalatio can achieve good clinical efficacy in treating chronic obstructive pulmonary disease,which can significantly improve the hypoxic state and lung function of patients,and has high safety.

Key words： Chronic obstructive pulmonary disease Tiotropium Bromide Budesonide Oxygenation index Pulmonary function

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	DU Yue-jun

Cite this article:

DU Yue-jun. Clinical effect of Tiotropium Brom ide combined with Budesonide atom ization inhalation in the treatment of chronic obstructive pulmonary disease[J]. 中国当代医药, 2020, 27(17): 65-68.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I17/65

[1]	代岩，金博，姜乐.糖皮质激素联合特布他林治疗对慢阻肺急性加重期外周血单核细胞PD-1/PD-L1表达的影响[J].中国免疫学杂志，2019，35（13）：1621-1626.
[2]	邓璀，姚桂锐，林海容.高流量通气治疗慢性阻塞性肺疾病急性加重期合并呼吸衰竭患者的效果观察[J].护理实践与研究，2019，16（11）：29-31.
[3]	刘雪琴，关晓暄，孙立军.噻托溴铵联合沙美特罗/氟替卡松治疗哮喘——慢阻肺重叠综合征的临床评价[J].临床肺科杂志，2017，22（3）：513-516.
[4]	肖幸，杨梦晨，刘建，等.噻托溴铵喷雾剂替换沙美特罗替卡松治疗老年慢性阻塞性肺疾病的临床研究[J].中国医院药学杂志，2019，39（17）：1787-1790.
[5]	中华医学会，中华医学会《中华全科医师杂志》编辑委员会，呼吸系统疾病基层诊疗指南编写专家组，等.慢性阻塞性肺疾病基层诊疗指南[J].中华全科医师杂志，2018，17（11）：871-877.
[6]	文富强，陈磊.GOLD 2017更新与中国慢阻肺临床实践[J].西部医学，2018，30（1）：1-2.
[7]	郁震，曹娟，王红梅，等.噻托溴铵联合沙美特罗替卡松对慢阻肺急性加重期患者免疫功能的影响[J].临床肺科杂志，2016，21（5）：795-798.
[8]	李明，李林旭，王朔，等.噻托溴铵与异丙托溴铵治疗哮喘-慢阻肺重叠综合征效果及对血清TNF-α、IL-6影响的比较[J].疑难病杂志，2017，16（7）：673-677.
[9]	安英俊，李红义，张祥杰.布地奈德福莫特罗联合噻托溴铵治疗哮喘-慢阻肺重叠综合征的效果观察[J].临床研究，2019，27（6）：102-103.
[10]	赵丽，李丽红，窦雪.布地奈德联合沙丁胺醇在慢阻肺急性加重期治疗中的效果观察[J].中国医药指南，2019，17（4）：144-145.
[11]	周三梅.布地奈德+沙丁胺醇雾化吸入治疗慢阻肺急性加重期患者用药价值分析[J].中外医学研究，2019，17（9）：109-110.
[12]	许硕，刘欣，袁太文，等.布地奈德联合特布他林治疗慢性阻塞性肺疾病急性加重期的疗效观察[J].中国医院用药评价与分析，2016，16（8）：1033-1035.
[13]	李研，佟飞，米香.布地奈德福莫特罗粉吸入剂联合噻托溴铵粉吸入剂治疗ACOS的疗效及其对患者血清hs-CRP、EOS的影响[J].海南医学，2017，28（18）：2997-3000.
[14]	刘苔，李娅，杜卫祺，等.不同雾化方法吸入布地奈德对慢性阻塞性肺疾病急性加重期患者胸肺顺应性及动脉血气指标的影响[J].中国现代医学杂志，2017，27（15）：115-118.
[15]	张华根，曾伟坚，彭贵霞，等.布地奈德福莫特罗粉吸入剂联合孟鲁司特钠在哮喘-慢阻肺重叠综合征患者治疗中的应用研究[J].实用药物与临床，2018，21（7）：811-814.