自拟补肾活血助孕汤配合温针灸八<span style=

Abstract
Figure/Table
References (19)
Related Citation (11)

Download: PDF (0 KB) HTML (45 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the clinical effect of self-made Bushen Huoxue Zhuyun Decoction combined with warm acupuncture at Baliao acupoint in the treatment of occult primary ovarian insufficiency (POI)with infertility.Methods Sixty patients with occult POI combined with infertility who were treated in the Department of Integrated Traditional Chinese and Western Medicine of HubeiMaternal and Child Health Hospital from March 2017 to December 2018 were selected as the research objects,and they were divided into three groups according to the random alphabet:Letrozole group(group A),Letrozole+Complex Packing Estradiol Tablets/Estradioland Dydrogesterone Tablets(Fenmorphone)+Aspirin group(group B)and Letrozole+Dydrogesterone+Chinesemedicine+warm acupuncture group(group C),20cases in each group.Patients in group A simply used low-dose Letrozole to induce ovulation.Patients in group B were given Complex Packing Estradiol Tablets/Estradioland Dydrogesterone Tablets(white tablets)1to 2mg orally on the tenth day ofmenstruation on the basis of group A,and given Complex Packing Estradiol Tablets/Estradioland Dydrogesterone Tablets(gray tablets)1to 2tablets plus Aspirin Enteric-coated Tablets 25mg for oral administration at 72hours after ovulation.On the basis of group A,the patients in group C were given Chinese medicine self-made Bushen Huoxue Zhuyun Decoction on the fifth day of themenstrual cycle,combined with warm acupuncture at Baliao acupoint twice a week,and given Dydrogesterone Tablets orally 72hours after ovulation,1tabletat a time,twice a day.The treatment period was 6months,and the endometrial thickness,shape,spiral uterine artery blood flow parameters(pulse index [PI],resistance index [RI],peak systolic velocity/end diastolic peak velocity [S/D]),pregnancy rate and spontaneous abortion rate were counted among the three groups.Results The pregnancy rates in group B and group C were higher than those in group A,the differenceswere statistically significant(P＜0.05).There was no significant difference in the pregnancy rate between group B and group C (P＞0.05).There was no significant difference in spontaneous abortion rate among the three groups (P＞0.05).The endometrial thickness in group B and group C was higher than that in group A,with statistically significant differences(P＜0.05).There was no statistically significant difference in endometrial thickness between group B and group C (P＞0.05).The proportion of endometrium A in group C was higher than that in group A and group B,with statistically significant differences(P＜0.05).There was no statistically significant difference in the proportion of endometrium A between group A and group B (P＞0.05).The PIof group B and group C was lower than that of group A,with statistically significant differences(P＜0.05).There was no statistically significant difference in PIbetween group B and group C(P＞0.05).The RIand S/D in group B and group C were lower than those in group A,and those in group C were lower than those in group B,with statistically significant differences(P＜0.05).Conclusion The combination of Chinese medicine and acupuncture can definitely improve the endometrial thickness and uterine artery blood flow parameters,and can increase the clinical pregnancy rate of patientswith occult POIwith infertility.

Key words： Occult primary ovarian insufficiency Pregnancy rate Uterine artery blood flow parameters Endometrial receptivity Baliao acupoint Oral administration of Chinesemedicine

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	XIANG Xi
	HUANG Xiao-tao
	GE Man
	GAO Jing

Cite this article:

XIANG Xi,HUANG Xiao-tao,GE Man, et al. Clinical effect of self-made Bushen Huoxue Zhuyun Decoction combined with warm acupuncture at Baliao acupoint in the treatment of occult primary ovarian insufficiency with infertility[J]. 中国当代医药, 2020, 27(17): 162-166.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I17/162

[1]	黄杭珍.不孕症流行现状与趋势探讨[J].中医药管理杂志，2016，24（3）：11-12.
[2]	Cox L，Liu JH.Primary ovarian insufficiency：an update[J].Int JWomens Health，2014，6（6）：235-243.
[3]	Gonen Y，Casper RF，Jacobson W，et al.Endomential thickness and growth during ovarian stimulation：a possible predictor of implantation in in-vitro fertilization[J].Fertil Steril，1989，52（3）：446-450.
[4]	Welt CK.Primary ovarian insufficiency：a more accurate term for premature ovarian failure[J].Clin Endocrinol（Oxf），2008，68（4）：499-509.
[5]	Sallam HN，Ezzeldin F，Agameya AF，et al.The definition of′poor response′：Bologna criteria[J].Hum Reprod，2011，27（2）：626-627.
[6]	Nygren KG，Andersen AN.Assisted reproductive technology in Europe，1998.Results generated from European registers by ESHRE.European Society of Human Reproduction and Embryology[J].Hum Reprod，2001，16（11）：2459-2471.
[7]	王琼，周灿权.反复种植失败的病因探讨[J].中国实用妇科与产科杂志，2013，29（2）：100-102.
[8]	Sudoma I，Goncharova Y，Zukin V.Optimization of cryocycles by using pinopode detection in patients with multiple implantation failure：preliminary report[J].Reprod Biomed Online，2011，22（6）：590-596.
[9]	杨仁翔，武泽.子宫内膜容受性的研究进展[J].实用妇产科杂志，2019，35（1）：19-23.
[10]	高琦，蔡霞.HOXA10及其下游基因Emx 2、整合素β3与子宫内膜容受性[J].国际生殖健康/计划生育杂志，2012，31（2）：119-122.
[11]	Dechaud H，Bossuetlle E，Bousquet PJ，et al.Optimal timing of ultrasonographic and doppler evaluation of uterine receptivity to implantation[J].Reprod Biomed Online，2008，16（3）：368-375.
[12]	李玥，杨宇，钱林学.应用超声指标评估子宫内膜容受性研究进展[J].中国医学装备，2017，14（12）：18-22.
[13]	陈瑾.体外授精-胚胎移患者三维能量多普勒子宫内膜血流参数与妊娠结局的关系[A].中国超声医学工程学会.中国超声医学工程学会第十一届全国超声医学学术大会论文汇编[C].中国超声医学工程学会：中国超声医学工程学会，2012：40-41.
[14]	曹文，贾书娜，刘颖，等.中医药改善子宫内膜容受性提高妊娠率的研究进展[J].河北中医，2017，39（11）：1746-1751.
[15]	王伟明，王扬、吴佳霓，等，电针“中髎”“天枢”改善早发性卵巢功能不全模型大鼠卵巢功能的实验研究[J].中国针灸，2018，38（5）：519-526.
[16]	杨林，兰颖，杨丽洁，等.针灸改善子宫内膜容受性疗效的Meta分析[J].中华中医药学刊，2019，37（5）：1102-1109.
[17]	马娟娟，张勤华，翁晓晨，等.温针灸对IVF-ET肾阳虚型反复移植失败患者子宫内膜容受性及妊娠结局的影响[J].上海针灸杂志.2018，37（12）：1339-1344.
[19]	汤伟伟，马小平，朱利，等.补肾活血汤对子宫内膜异位症相关性不孕患者子宫内膜容受性的影响[J].中国医药导报，2016，13（25）：123-124.
[18]	PaulusWE，Zhang M，Strehler E，etal.Influence of acupuncture on the pregnancy rate inpatientswho undergo assisted reproduction therapy[J].Fertil Steril，2002，77（4）：721-724.