急性脑梗死非溶栓患者出血转化的影响因素分析

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Abstract Objective To analyze the influencing factors of hemorrhage transformation in acute ischemic stroke patients without thrombolytic therapy.Methods Retrospective analysiswas performed in the clinical data of 802acute ischemic stroke patientswithout thrombolytic therapy from January 2017 to December 2018 in our hospital,and they were divided into hemorrhage transformation group(35cases)and non-hemorrhage transformation group(767 cases)according to whether hemorrhage transformation occurred or not.The related factors of the two groupswere compared,and the factorswith statistical differenceswere further included in themultivariate Logistic regression analysis.Results Univariate analysis results showed that there were statistically significant differences in age,history of hypertension,atrial fibrillation,coronary heart disease,heart disease,stroke type,large-area ischemic stroke,national institutes of health stroke scale(NIHSS)score,antiplatelet drugs,and albumin level between the two groups(P＜0.05).Multivariate Logistic regression analysis showed thathigh NIHSSscore,large-area ischemic stroke and low albumin levelwere independent risk factors for hemorrhagic transformation,and history ofhypertension was an independent protective factor for hemorrhagic transformation(P＜0.05).Conclusion Low albumin level,high NIHSS score,large-area ischemic stroke are independently risk factors for hemorrhagic transformation of acute ischemic stroke patients without thrombolytic therapy and hypertension is an independently protective factor,which has provided great help in clinical decision-making,but large sample of innovative researches are still needed to further confirm this conclusion.

Key words： Albumin Hemorrhagic transformation Acute ischemic stroke Without thrombolytic therapy

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	Articles by authors
	LIU Ming-su
	TANG Ye
	FU Qing
	LI Guang-qin

Cite this article:

LIU Ming-su,TANG Ye,FU Qing, et al. Analysis of influencing factors of hemorrhage transformation in acute ischem ic stroke patients without thrombolytic therapy[J]. 中国当代医药, 2020, 27(17): 16-20.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I17/16

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