壳多糖酶3样蛋白1在癌症发展中的作用及其应用价值

Abstract
Figure/Table
References (39)
Related Citation (15)

Download: PDF (0 KB) HTML (42 KB)
Export: BibTeX | EndNote (RIS)

Abstract Chitinase-3-like protein 1(CHI3L1)is a chitinase like proteins(CLPs)without chitinase activity.In recent years,international researches on the relationship between CHI3L1and cancer have gradually increased.CHI3L1plays an important role in immune response,inflammation,and extracellular matrix composition,which can affect tumor growth,metastasis,and response to treatment by regulating the tumormicroenvironment.Some researchers have recommended CHI3L1as a new tumormarker for predicting the occurrence,development and prognosis of tumors.At present,people′s understanding of CHI3L1and its relationship with cancer is not enough.This paper collects and summarizes the internationally advanced research results on CHI3L1and cancer in recent years,from the aspects of the mechanism of CHI3L1in cancer development,expression in human cancer,related signaling pathways in cancer development and research value in cancer treatment,so as to explain the role and application value of CHI3L1in the development of cancer.

Key words： Chitinase-3-like protein 1 Cancer Application value Tumormarker

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CHEN Yu
	XIONG Juan

Cite this article:

CHEN Yu,XIONG Juan. Role of chitinase 3-like protein 1 in cancer development and its application value[J]. 中国当代医药, 2020, 27(17): 21-24.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I17/21

[4]	Shao R.YKL-40 acts as an angiogenic factor to promote tumor angiogenesis[J].Front Physiol，2013，4：122.
[5]	Chen Y，Zhang S，Cao J，et al.Shrimp antiviralmja-miR-35targets CHI3L1in human M2macrophages and suppresses breast cancermetastasis[J].Front Immunol，2018，9：2071.
[10]	Mitsuhashi A，Matsui H，Usui H，et al.Serum YKL-40 as a marker for cervical adenocarcinoma[J].Ann Oncol，2009，20（1）：71-77.
[29]	Thorn AP，Daugaard S，Christensen LH，et al.YKL-40 protein in osteosarcoma tumor tissue[J].APMIS，2016，124（6）：453-461.
[1]	Hussain M，Wilson JB.New paralogues and revised time line in the expansion of the vertebrate GH18 family[J].JMol Evol，2013，76（4）：240-260.
[2]	Kognole AA，Payne CM.Inhibition ofmammalian glycoprotein YKL-40：IDENTIFICATION OF THE PHYSIOLOGICAL LIGAND[J].JBiol Chem，2017，292（7）：2624-2636.
[3]	Sanchez C，Mazzucchelli G，Lambert C，et al.Comparison of secretome from osteoblasts derived from sclerotic versus non-sclerotic subchondral bone in OA：A pilot study[J].PLoS One，2018，13（3）：e0194591.
[6]	Kim DH，Park HJ，Lim S，et al.Regulation of chitinase-3-like-1in T cell elicits Th1and cytotoxic responses to inhibit lungmetastasis[J].Nat Commun，2018，9（1）：503.
[7]	He CH，Lee CG，Dela Cruz CS，et al.Chitinase 3-like 1regulates cellular and tissue responses via IL-13receptorα2[J].Cell Rep，2013，4（4）：830-841.
[8]	Subramaniam R，Mizoguchi A，Mizoguchi E.Mechanistic roles of epithelial and immune cell signaling during the developmentof colitis-associated cancer[J].Cancer Res Front，2016，2（1）：1-21.
[9]	Fuksiewicz M，Kotowicz B，Rutkowski A，et al.The assessmentof clinicalusage and prognostic value of YKL-40 serum levels in patientswith rectal cancerwithout distantmetastasis[J].Technol Cancer Res Treat，2018，17：1533033818765209.
[11]	Rusak A，Jablonska K，Piotrowska A，etal.The roleofCHI3L1expression in angiogenesis in invasive ductal breast carcinoma[J].Anticancer Res，2018，38（6）：3357-3366.
[12]	Steponaitis G，Skiriute D，Kazlauskas A，et al.High CHI3L1expression is associated with glioma patient survival[J].Diagn Pathol，2016，11：42
[13]	Chen YL，Zhang SY，Wang QZ，et al.Tumor-recruited M2macrophages promote gastric and breast cancer metastasis via M2macrophage-secreted CHI3L1protein[J].JHematol Oncol，2017，10（1）：36
[14]	Thongsom S，Chaocharoen W，Silsirivanit A，et al.YKL-40/chitinase-3-like protein 1is associated with poor prognosis and promotes cell growth and migration of cholangiocarcinoma[J].Tumor Biol，2016，37（7）：9451-9463.
[15]	Jeet V，Tevz G，Lehman M，et al.Elevated YKL40 is associated with advanced prostate cancer（PCa）and positively regulates invasion and migration of PCa cells[J].Endocr Relat Cancer，2014，21（5）：723-737.
[16]	Ma JY，Li RH，Huang K，et al.Increased expression and possible role of chitinase 3-like-1in a colitis-associated carcinomamodel[J].World JGastroenterol，2014，20（42）：15736-15744.
[17]	Cohen N，Shani O，Raz Y，et al.Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1[J].Oncogene，2017，36（31）：4457-4468.
[18]	Ngernyuang N，Shao R，Suwannarurk K，et al.Chitinase 3like 1（CHI3L1）promotes vasculogenicmimicry formation in cervical cancer[J].Pathology，2018，50（3）：293-297.
[19]	Francescone RA，Scully S，Faibish M，et al.Role of YKL-40 in the angiogenesis,radioresistance,and progression of glioblastoma[J].JBiolChem，2011，286（17）：15332-15343.
[20]	Hamilton G，Rath B.Circulating tumor cell interactions withmacrophages：implications for biology and treatment[J].Transl Lung Cancer Res，2017，6（4）：418-430.
[21]	Heiland DH，Ferrarese R，Claus R，et al.c-Jun-N-terminal phosphorylation regulates DNMT1expression and genome widemethylation in gliomas[J].Oncotarget，2017，8（4）：6940-6954.
[22]	Miyata H，Ashizawa T，Iizuka A，et al.Combination of a STAT3inhibitor and an mTOR inhibitor against a temozolomide-resistantglioblastoma cell line[J].CancerGenomics Proteomics，2017，14（1）：83-91.
[23]	Wang XW，Cai CL，Xu JM，et al.Increased expression of chitinase 3-like 1is a prognosismarker for non-small cell lung cancer correlated with tumor angiogenesis[J].Tumor Biol，2015，36（2）：901-907.
[24]	Batista K，Costa B，Pablo I，et al.Analysis of Olig2and YKL-40 expression：a clinicopathological/immunohistochemical study for the distinction between subventricular zoneⅡandⅢglioblastomas[J].Folia Neuropathol，2016，54（1）：31-39.
[25]	Luo DY，Chen HB，Lu PH，et al.CHI3L1overexpression is associated withmetastasis and is an indicator of poor prognosis in papillary thyroid carcinoma[J].Cancer Biomark，2017，18（3）：273-284.
[26]	Krogh M，Christensen I，Bouwhuis M，et al.Prognostic and predictive value of YKL-40 in stage IIB-IIImelanoma[J].Melanoma Res，2016，26（4）：367-376.
[27]	Kemik P，SaatliB，Yildirim N，etal.Diagnostic and prognostic values of preoperative serum levels of YKL-40，HE-4and DKK-3in endometrial cancer[J].Gynecol Oncol，2016，140（1）：64-69.
[28]	Johansen JS，Christensen IJ，Jorgensen LN，et al.Serum YKL-40 in risk assessment for colorectal cancer：a prospective study of 4，496subjects at risk of colorectal cancer[J].Cancer Epidemiol Biomarkers Prev，2015，24（3）：621-626.
[30]	HvolrisMH，Piper TB，Hammer E，etal.Increased serological cancer-associated biomarker levelsat largebowelendoscopy and risk of subsequent primary cancer[J].Scand JGastroenterol，2016，51（7）：860-865.
[31]	Faibish M，Francescone R，Bentley B，et al.A YKL-40-neutralizing antibody blocks tumor angiogenesis and progression:a potential therapeutic agent in cancers[J].Mol Cancer Ther，2011，10（5）：742-751.
[32]	Pinet S，Bessette B，Vedrenne N，et al.TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells[J].Oncotarget，2016，7（31）：50 349-50 364.
[33]	Kim KC，Yun J，Son DJ，et al.Suppression of metastasis through inhibition of chitinase 3-like 1expression bymiR-125a-3p-mediated up-regulation of USF1[J].Theranostics，2018，8（16）：4409-4428.
[34]	Salvatore V，Focaroli S，Teti G，et al.Changes in the gene expression of co-cultured human fibroblast cells and osteosarcoma cells：the role ofmicroenvironment[J].Oncotarget，2015，6（30）：28 988-28 998.
[35]	Lee IA，Low D，Kamba A，et al.Oral caffeine administration ameliorates acute colitis by suppressing chitinase 3-like 1expression in intestinal epithelial cells[J].JGastroenterol，2014，49（8）：1206-1216.
[36]	Wang YB，Wong CW，Yan MF，et al.Differential regulation of the pro-inflammatory biomarker，YKL-40/CHI3L1，by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3pathways in glioblastoma[J].Cancer Lett，2018，429：54-65.
[37]	Peng H，Su Q，Lin ZC，et al.Potential suppressive effects of theophylline on human rectal cancer SW480 cells in vitro by inhibiting YKL-40 expression[J].Oncol Lett，2018，15（5）：7403-7408.
[38]	Chiang YC，Lin HW，Chang CF，et al.Overexpression of CHI3L1is associated with chemoresistance and poor outcome of epithelial ovarian carcinoma[J].Oncotarget，2015，6（37）：39 740-39 755.
[39]	Libreros S，Garcia-Areas R，Shibata Y，et al.Induction of proinflammatorymediators by CHI3L1is reduced by chitin treatment：decreased tumor metastasis in a breast cancer model[J].Int JCancer，2012，131（2）：377-386.