支气管哮喘患者呼出气一氧化氮与诱导痰细胞百分比、外周血嗜酸性粒细胞计数及肺功能水平的相关性研究

Abstract
Figure/Table
References (18)
Related Citation (15)

Download: PDF (0 KB) HTML (36 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To study the correlation of fractional exhaled nitric oxide (FeNO)with eosinophils percentage in induced sputum,eosinophils(EOS)count in peripheral blood and lung function level in patientswith bronchial asthma(BA),and to explore its significance in clinical diagnosis and treatment of BA.Methods A total of 47 cases of BA patients treated in Outpatient of Department of Respiration and Department of Inpatient,Chronic Disease Prevention Hospital of Qingyuan City from February 2018 to February 2019 were selected as the BA group,and 45cases of non-BA patients treated in department of respiration of our hospitalwere selected as the non-BA group during the same period.Lung function detector was used to detect the ventilation function of lung tissues in each group,and the forced expiratory volume for 1second expressed as a percentage of the forced vital capacity(FEV1%)was calculated.The EOS count in peripheral blood of patients in each group was detected by automatic blood cell analyzer.FeNO in each group was detected by nitric oxide (NO)detection kit,and hematoxylin-eosin (HE)stainingwas used to detect the percentage of induced sputum cells in each group.Results The FeNO,eosinophils percentage in induced sputum and peripheral blood EOS count of the BA group were higher than those of the non-BA group (P＜0.05),while FEV1%was lower than that of the non-BA group (P＜0.05).The FeNO of the BA group was positively correlated with the eosinophils percentage in induced sputum and peripheral blood EOS count(r=0.572,0.643,P＜0.05),but not correlated with FEV1%(r=-0.005,P＞0.05).Conclusion There is no significant correlation between the degree of respiratory airway obstruction and the severity of respiratory airway inflammatory response,so FeNO could not replace the physiological function detection of lung tissues.

Key words： Bronchial asthma Fractional exhaled nitric oxide Eosinophils count in peripheral blood Eosinophils Lung function

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHOU Zheng-hua
	LIANG Zhi-yong
	DENG Xiao-dong

Cite this article:

ZHOU Zheng-hua,LIANG Zhi-yong,DENG Xiao-dong. Correlation study of fractional exhaled nitric oxide with eosinophils percentage in induced sputum,eosinophils count in peripheral blood and lung function level in patients with bronchial asthma[J]. 中国当代医药, 2020, 27(17): 62-64转68.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I17/62

[2]	牛斌，熊安英.呼出气一氧化氮评估慢性阻塞性肺疾病患者气道炎症临床研究[J].中华实用诊断与治疗杂志，2016，30（5）：503-505.
[3]	张连莲，刘洋，赵尔为，等.呼出气一氧化氮在支气管哮喘诊断中的价值[J].中国实验诊断学，2015，19（8）：1287-1289.
[4]	刘敏，许西琳，刘冬，等.呼出气一氧化氮和外周血嗜酸性粒细胞百分率对支气管哮喘诊断和病情评估价值[J].中华实用诊断与治疗杂志，2017，31（8）：769-771.
[1]	Matsunaga K，Hirano T，Oka A，et al.Persistently high exhaled nitric oxide and loss of lung function in controlled asthma[J].Allergy Int，2016，65（3）：266-271.
[5]	陈博智.支气管哮喘患者呼出气一氧化氮与肺功能、诱导痰及外周血嗜酸性粒细胞比例的相关性分析及其临床意义[J].中国实用医药，2019，14（2）：43-44.
[6]	金芬华，杜俊华，戴元荣，等.支气管哮喘患者呼出气一氧化氮与肺功能、诱导痰及外周血嗜酸性粒细胞比例等指标的相关性分析及其临床意义[J].浙江医学，2016，38（17）：1401-1404.
[7]	李伟棠，黄兰卿，梁红卫，等.呼出气一氧化氮检测对支气管哮喘患者长期管理的意义[J].中国医药导报，2014，11（30）：138-142.
[8]	陈钊成，陈必达，张卫芳，等.呼出气一氧化氮检测在支气管哮喘临床诊断中的应用[J].黑龙江医学，2015，39（6）：650-651.
[9]	中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南（2016年版）[J].中华结核和呼吸杂志，2016，39（9）：675-697.
[10]	刘念，罗红，刘志光.支气管哮喘患者呼出气一氧化氮与血嗜酸性粒细胞数量及比例和免疫球蛋白E的相关性分析[J].医学临床研究，2017，34（5）：879-881，885.
[11]	严瑾，金晓燕，郑聪，等.支气管哮喘患者呼出气一氧化氮及诱导痰的相关性研究[J].国际呼吸杂志，2015，35（5）：325-328.
[12]	雒志明，高赏，任魁，等.支气管哮喘患者外周血嗜酸性粒细胞计数与诱导痰嗜酸性粒细胞百分比和呼出气一氧化氮的相关性[J].山西医科大学学报，2017，48（10）：1039-1043.
[13]	张雅军.呼出气一氧化氮测定与哮喘患者血EOS、IgE及FEV1/pred相关性分析[J].中国实用医药，2014，9（19）：66-67.
[14]	梁连哨，邓静敏，邹小英，等.中性粒细胞性慢性持续期哮喘患者治疗前后外周血和诱导痰中嗜酸性粒细胞阳离子蛋白水平及其临床意义[J].广西医学，2016，38（3）：324-327.
[15]	齐力，姜丹.诱导痰查嗜酸粒细胞对支气管哮喘患者调整治疗的指导意义[J].哈尔滨医科大学学报，2017，51（2）：180-182.
[16]	霍龙，范晓云，陆兆双，等.哮喘急性发作FeNO与外周血嗜酸粒细胞及肺功能的相关性研究[J].临床肺科杂志，2014，19（4）：583-585.
[17]	吴淑红，荣福，欧阳雁弟.支气管哮喘患者呼出气一氧化氮与外周血嗜酸性粒细胞计数和肺功能水平的相关性研究[J].中国现代药物应用，2018，12（7）：41-42.
[18]	夏清，潘频华，王展，等.呼出气一氧化氮检测在支气管炎症性肺疾病中的临床应用.中南大学学报（医学版），2014，39（4）：365-370.