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Quick Search     Adv Search 2020 Vol. 27, No. 7 Published: 2020-03-08   4 Correlation analysis of serum cystatin C, uric acid and bone mineral density in patients with type 2 diabetes mellitus MU Yu-jing; LI Jun; LI Qing-ju; FAN Meng-di Objective To explore the relationship between serum cystatin C, uric acid and bone mineral density in patients with type 2 diabetes mellitus, and to analyze the related factors of diabetic osteoporosis. Methods From January 2018 to May 2019, 228 patients with type 2 diabetes treated in the Department of Endocrinology, the Second Affiliated Hospital of Zhengzhou University were selected. According to the World Health Organization (WHO) diagnosis standard of osteoporosis, they were divided into normal bone mass group (43 cases), low bone mass group (87 cases), osteoporosis group(77 cases)and severe osteoporosis group(21 cases).The general data of patients were collected.The correlation between biochemical parameters and bone mineral density was analyzed and the possible mechanism was discussed. Results There were significant differences in sex, age, course of disease, diastolic pressure, glycosylated hemoglobin, total cholesterol,triacylglycerol,high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, blood phosphorus, alkaline phosphatase, blood creatinine, blood uric acid, serum cystatin C, 25 hydroxyvitamin D and estimated glomerular filtration rate, lumbar spine 1-4 (L1～4) bone mineral density, bilateral femoral neck bone mineral density among the four groups (P＜0.05). There were no significant differences in body mass index、systolic blood pressure、fasting plasma glucose、2-hour postprandial glucose C-peptide、serum Ca、blood urea nitrogen among the four groups (P＞0.05). Correlation analysis showed that bone mineral density of L1～4 positively correlated with serum uric acid,alkaline phosphatase (r=0.334, 0.443; P＜0.05), negatively correlated with serum P, glycosylated hemoglobin, cystatin C(r=-0.224, -0.371, -0.357; P＜0.05); bone mineral density of the left femoral neck positively correlated with serum uric acid, alkaline phosphatase (r=0.242, 0.607; P＜0.05), negatively correlated with serum P, glycosylated hemoglobin, cystatin C (r=-0.156, -0.351, -0.442; P＜0.05)；bone mineral density of the right femoral neck positively correlated with serum uric acid、alkaline phosphatase (r=0.229, r=0.609; P ＜0.05), negatively correlated with serum P, glycated hemoglobin, cystatin C (r=-0.134, -0.276, -0.414; P＜0.05). Multiple linear regression analysis showed that glycosylated hemoglobin, alkaline phosphatase, serum cystatin C and uric acid were the related factors affecting bone mineral density in patients with type 2 diabetes mellitus (P＜0.05). Conclusion High levels of serum cystatin C may be risk factors for osteoporosis in patients with type 2 diabetes, and high blood levels of uric acid may be the protection factors. 2020 Vol. 27 (7): 4-8 [Abstract] ( 91 ) HTML (38 KB)  PDF  (0 KB)  ( 9 ) 9 Study on characteristic chromatogram of Juhong Granules PENG Shan-gui； WANG Liang； WEN Yong-sheng Objective To study the characteristic chromatogram of Juhong Granuls and provide a reliable method for scientific evaluation and effective control of quality. Methods High performance liquid chromatography (ultraviolet detection) was used to determine the components of Juhong Granuls, Sunfire C18 (250 mm×4.6 mm, 5 μm) was used as the chromatographic column. The mobile phase consisted of acetonitrile-water, with gradient elution at the flow rate of 0.5 ml/min, column temperature was 30℃. Detection wavelength was 283 nm. The sample solution was prepared by direct ultrasonic treatment with methanol. The main components of seven herbs in the prescription of tangerine granules were detected and the characteristic spectrum of tangerine granules was established. Results There were 11 common characteristic peaks of Juhong Granuls, and the characteristic chromatographic peaks were classified into seven medicinal herbs in the prescription, namely, Citrigrandis Exocarpium, Citripericarpium Reticulatae, Glycyrrhizae Radixet Rhizome, Plycyrrhizae Radix, Rehmanniae Radix, Trichosanthis Pericarpium Farfarae Flos, and the characteristic peak 5 was glycyrrhizin, peak 7(S) was the reference naringin and peak 9 was hesperidin. The precision, repeatability and stability test results showed, the RSD of the relative retention time of each common peak was less than 1.0%, and the RSD of the relative peak area was less than 4.0%. Conclusion The etablished characteristic chromatogram method of Juhong Granuls is simple, accurate, and can be used for the quality control and evaluation of Juhong Granuls. 2020 Vol. 27 (7): 9-13转17 [Abstract] ( 86 ) HTML (43 KB)  PDF  (0 KB)  ( 11 ) 14 Effect of Shujin Jianyao Pills on articular cartilage of New Zealand rabbit knee osteoarthritis models LI Rui-peng； CHEN Di-xin； GUO Qiu-ping； NI Qing-chun； ZHOU Jiu-yao Objective To study the effect of Shujin Jianyao Pills on articular cartilage of New Zealand rabbit knee osteoarthritis model. Methods After one week of adaptive feeding, 12 New Zealand rabbits were randomly selected as the sham operation group. The osteoarthritis models were prepared by articular cartilage defect caused by surgery in other animals. After 4 weeks of modeling, the animals were randomly divided into model group, glucosamine hydrochloride group (positive control), Shujin Jianyao Pills low, middle and high dose groups, 12 cases in each group, half male and half female. After grouping, the animals were intragastrically administrated with drugs once daily for 28 days. The therapeutic effect and mechanism of Shujin Jianyao Pills on osteoarthritis were studied by detecting the range of knee joint activity, local tenderness threshold, whole blood viscosity, inflammatory cytokines of articular cavity flushing fluid and articular cartilage histopathology. Results The knee joint range and local tenderness threshold of the waist in the Shujin Jianyao Pills middle and high dose groups were higher than those in the model group, the whole blood viscosity and interleukin 1β (IL-1β), tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) levels in articular cavity were lower than those in the model group, and the differences were statistically significant (P＜0.05). The articular cartilage scores of the glucosamine hydrochloride group and the Shujin Jianyao Pills high dose group were lower than those of the model group, and the differences were statistically significant (P＜0.05). Conclusion Shujin Jianyao Pills have a certain therapeutic effect on osteoarthritis. Improving hemorheology, reducing inflammatory cytokines in articular cavity and protecting articular cartilage may be the mechanism of its action. 2020 Vol. 27 (7): 14-17 [Abstract] ( 81 ) HTML (42 KB)  PDF  (0 KB)  ( 12 ) 18 Application status and thinking of the medical and educational integration model for children with autism spectrum disorder LI En-yao； LIU Zhi-hui； LI Li-guo； XIA Si-man； YU Qian； YIN Bao-qi； SUN Zhen-yu The autism spectrum disorder (ASD) is a widespread neurodevelopmental disorder. In the past, the treatment of children with autism was only carried out by special education institutions. The effect was not very significant. In recent years, the incidence of autism has been on the rise, and people are paying more and more attention to their treatment. The research on the treatment of autism is also more and more, research shows that "medical and educational integration" is currently an effective means of treating autism. However, at present, people have insufficient understanding of "medical and educational integration", and the medical and educational integration model has not been widely promoted, which severely limits the level of diagnosis and treatment of autism. This paper mainly discusses the current status of "medical and educational integration" in China, the existing problems, and thinks about its future development, and provides assistance for the promotion of the "medical and educational integration" model in the future. 2020 Vol. 27 (7): 18-20 [Abstract] ( 90 ) HTML (35 KB)  PDF  (0 KB)  ( 16 ) 21 Research progress of in-stent restenosis after stent implantation in symptomatic atherosclerotic intracranial stenosis PENG Wei； LUO Hai-yan Ischemic stroke refers to the disturbance of blood flow in the blood supply artery of the local brain tissue caused by various reasons, which leads to the ischemic hypoxic degeneration and necrosis of the brain tissue. At the same time, the corresponding clinical neurological function loss occurs. It is one of the diseases with the highest disability rate in the human disease spectrum, which brings heavy burden to the patients′ family and the whole society. In the TOAST etiology classification of ischemic stroke, the proportion of intracranial artery stenosis caused by large intracranial atherosclerosis is about 17.3%, in which intravascular interventional therapy has been widely used. With the development of stent therapy, long-term complications such as in-stent restenosis (ISR) have attracted more and more attention. On the basis of the research at home and abroad in recent years, this paper reviews the incidence, mechanism, risk factors, assessment methods and Countermeasures of ISR, so as to provide evidence for the safety and effectiveness of different intracranial endovascular stent therapy, and to provide help in the selection of treatment methods of intracranial atherosclerotic ischemic stroke and the perioperative and long-term management of patients. 2020 Vol. 27 (7): 21-24 [Abstract] ( 89 ) HTML (42 KB)  PDF  (0 KB)  ( 13 ) 25 Advances in interventional treatment of coronary heart disease and prevention of restenosis after operation WANG Xiao-dong Coronary heart disease is a heart disease caused by atherosclerotic lesions in the coronary arteries, leading to stenosis and obstruction of the blood vessels, myocardial ischemia, hypoxia and necrosis. Patients often have sudden pain in the chest area (narrowness, paroxysmal colic) after the onset of the disease, and the incidence and mortality of the disease are high, which seriously threatens the health of the patient. With the continuous development and improvement of medical technology and resources, percutaneous coronary intervention has gradually become the main treatment for coronary heart disease. The clinical effect is remarkable, and it has been well received by a wide range of medical staff and patients, helping many patients with coronary heart disease to survive. In order to further improve the therapeutic effect of coronary heart disease, this article reviews the progress of interventional treatment of coronary heart disease and prevention and treatment of postoperative restenosis. 2020 Vol. 27 (7): 25-27 [Abstract] ( 82 ) HTML (30 KB)  PDF  (0 KB)  ( 14 ) 28 Optimization of extraction process of Specnuezhenide in Jiawei Bazhen Mixture by orthogonal experiment ZHANG Wei ; SHI Xiao-hui Objective To optimize the extraction process of Specnuezhenide in Jiawei Bazhen Mixture. Methods The orthogonal experiment method was used to determine the content of the Specnuezhenide in the extract as the index, and the immersion time (A), the water addition ratio (B), the extraction times (C) and the extraction time (D) as factors which affected the extraction effect of the decoction were studied. High performance liquid chromatography (HPLC) was used to determine the content of Specnuezhenide in Jiawei Bazhen Mixture. Results A2B1C2D1 was the best extraction process for Jiawei Bazhen Mixture, that was, adding 6 times of water, immersing for 1 hour, and boiling and extracting 3 times for 1 hour each time. Conclusion The preferred process for this experiment is to obtain the highest extraction rate of mixture and the highest extraction rate of Specnuezhenide. 2020 Vol. 27 (7): 28-31 [Abstract] ( 90 ) HTML (41 KB)  PDF  (0 KB)  ( 13 ) 32 Determination of the content of dihydroparsley angelic acid ester as an active ingredient in Tongluo External Lotion ZHANG Yan-xia; LUO Yu; LI Xue-ming; ZHANG Yuan-hua Objective To study a method for the determination of dihydroparsin angelic acid ester in Tongluo External Lotion, so as to control the intrinsic quality of the preparation. Methods The content of dihydroparsin angelic acid ester in the washing solution was determined by high performance liquid chromatography (HPLC). The chromatographic elution column was Kromasil 100-5-C18 (4.6 mm×250 mm, 5 μm); mobile phase： acetonitrile-water (58∶42); flow rate： 1 ml per minute; detection wavelength： 330 nm; column temperature： 35℃; injection amount： 5 μl. Results Dihydroparsin angelic acid ester had a good linear relationship in the range of 44.45-889.00 μg/ml (r=0.9998). The relative standard deviation (RSD) of precision, repeatability and stability test results were all ＜2.00%, the average recovery rate of dihydroparsin angelic acid ester as angelic acid ester was 98.50% (RSD=1.79%, n=6), and the content of dihydroparsin angelic acid ester in the Tongluo External Lotion preparation should not be less than 0.20 mg/ml. Conclusion HPLC is used to determine the content of dihydroparsin as an active ingredient in Tongluo External Lotion. 2020 Vol. 27 (7): 32-35 [Abstract] ( 90 ) HTML (34 KB)  PDF  (0 KB)  ( 9 ) 36 Effect of Ulinastatin combined with Somatostatin in the treatment of acute pancreatitis LAI Run-kang; LU Zhun-biao Objective To explore the effect of Ulinastatin combined with Somatostatin in the treatment of acute pancreatitis in emergency. Methods Sixty patients with acute pancreatitis admitted to our hospital from January 2017 to January 2019 were enrolled in the study. According to the random number table method, they were divided into drug alone treatment group and combined drug treatment group, 30 cases in each group. The drug alone group was treated with Somatostatin, and the combined group was treated with Somatostatin+Ulinastatin. The therapeutic effects on pancreatitis including the time of blood amylase to return to normal range, the time of urinary amylase to return to normal range,hospital stay, acute and chronic health scores (APACHE Ⅱ), urine amylase monitoring level before and after treatment,blood amylase monitoring level, interleukin-6, tumor necrosis factor-α, and adverse reactions in the two groups were compared. Results The total effectiveness rate of the combined drug group was higher than that of the drug alone group, and the difference was statistically significant (P＜0.05). The time when the blood amylase returned to the normal range, the time when the urinary amylase returned to the normal range and the hospital stay in the combined drug group were shorter than those in the drug alone group, the difference were statistical singificant (P＜0.05). The APACHEⅡscore, urine amylase monitoring, blood amylase monitoring, interleukin-6 and tumor necrosis factor-α in the combined drug group were lower than those in the drug alone group, the difference were statistical singificant (P＜0.05).There was no statistical difference in the overall incidence of adverse reactions between the two groups (P＞0.05). Conclusion Application of Somatostatin+Ulinastatin is effective in the treatment of pancreatitis, which can improve blood urea gelatinase, control inflammation, facilitate recovery and shorten treatment time. 2020 Vol. 27 (7): 36-38 [Abstract] ( 77 ) HTML (32 KB)  PDF  (0 KB)  ( 14 ) 39 Effect of continuous positive airway pressure ventilation on vascular endothelium and fibrinolytic system in patients with obstructive sleep apnea syndrome XU Yan-fei； LI Yi-lu； CHEN Ji-ming； TAO Chun-yan； CHEN Ke-ying； WANG Jia-dun Objective To observe the effect of continuous positive airway pressure (CPAP) on vascular endothelium and fibrinolytic system in patients with obstructive sleep apnea syndrome (OSAHS). Methods A total of 84 patients with OSAHS admitted to our hospital from May 2017 to May 2019 were selected and randomly divided into CPAP group (42 cases) and control group (42 cases) by method of computer random control. The control group was given routine treatment,and CPAP group was given CPAP ventilation at least 6 hours per night on the basis of the control group. The treatment lasted for 2 weeks. The vascular endothelial related factors and coagulation and fibrinolysis system of the two groups were compared after treatment, including nitric oxide (NO), vascular endothelial growth factor (VEGF), endothelin-1(ET-1), plasma tissue plasminogen activator (t-PA), plasma fibrinogen (FIB), D-dimer (D-D), and changes of sleep score (ESS) and sleep apnea hypopnea index (AHI) were compared. Results ESS and AHI in CPAP group were lower than those in control group, NO in endothelial function was higher than that in control group, and VEGF and ET-1 were lower than those in control group, t-PA in coagulation and fibrinolysis system was higher than those in control group, FIB and D-D were lower than those in control group, the differences were statistically significant (P＜0.05).Conclusion CPAP can ameliorate nocturnal hypoxia, thus correcting the damage of vascular endothelial system and the change of coagulation and fibrinolysis system function. 2020 Vol. 27 (7): 39-41转44 [Abstract] ( 87 ) HTML (36 KB)  PDF  (0 KB)  ( 19 ) 42 Impact analysis of combination of Doxofylline and Tiotropium Bromide Powder on pulmonary function in patients with chronic obstructive pulmonary disease LI Xiao-ming Objective To analyze the value of Tiotropium Bromide Powder and Doxofylline in the treatment of patients with chronic obstructive pulmonary disease （COPD）. Methods 200 patients with COPD admitted to our hospital from January 2016 to January 2018 were enrolled in the study. According to the random number table method, they were divided into observation group (100 cases) and control group (100 cases). The control group was treated with Doxofylline,and the observation group was treated with Doxofylline combined with Tiotropium Bromide Powder. The lung function and quality of life of the two groups were compared. Results The 1 second forced respiratory volume （FEV1) in the observation group was (2.35±0.48) L, which was higher than that in the control group of (1.99±0.56) L, the difference was statistically significant (P＜0.05); the forced vital capacity （FVC) in the observed group was (2.49±0.51) L, which was higher than that of the control group of (2.21±0.38) L, and the difference was statistically significant (P＜0.05). The FEV1/FVC of the observation group was (62.35±8.48)%, which was higher than that of the control group of (57.62±7.48)%, and the difference was statistically significant (P＜0.05). The scores of quality life of the observation group was(10.26±2.48) points, which was higher than that of the control group of (6.26±1.49) points, the difference was statistically significant (P＜0.05). Conclusion Combined with Doxofylline and Tiotropium Bromide Powder, patients with COPD whether it is lung function or quality of life, have been significantly improved. 2020 Vol. 27 (7): 42-44 [Abstract] ( 96 ) HTML (30 KB)  PDF  (0 KB)  ( 11 ) 45 Application effect of aerobic exercise in patients with chronic heart failure WU Mei-xia； YU Mu-sheng； WU Chun-yan； SU Cai-juan； WU Zhen-yue； HUANG Qi-yi Objective To explore the application effect of aerobic exercise in patients with chronic heart failure. Methods Eighty patients with chronic heart failure treated in our hospital from March 2017 to December 2018 were selected as research subjects. They were divided into observation group and control group according to the complete randomization, with 40 cases in each group. In the observation group, basic medicine combined with aerobic exercise was used,and in the control group, basic medicine alone was applied. The 6-minute walking distance, diastolic blood pressure,systolic blood pressure, heart rate, left ventricular ejection fraction, and quality of life scores including mental health,general condition, energy, physical function were compared between the two groups. Results The 6-minute walking distance after treatment in the observation group was longer than that in the control group, and the difference was statistically significant (P＜0.05). The diastolic pressure, systolic pressure and heart rate after treatment in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The left ventricular ejection fraction after treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The scores of mental health, general condition, energy and physical function after treatment in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Aerobic exercise can effectively prolong the 6-minute walking distance of patients with chronic heart failure and improve their cardiac function, which is worth popularizing and applying. 2020 Vol. 27 (7): 45-47 [Abstract] ( 72 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 48 Effect of Metoprolol combined with Trimetazidine on inflammatory factors and cardiac function in patients with coronary heart disease and heart failure TANG Zeng-yao； LIU Ji-wen； WANG Xin-wang； ZHU Bao-cheng； LIU Yu-lian Objective To investigate the effect of Metoprolol combined with Trimetazidine on inflammatory factors and cardiac function in patients with coronary heart disease and heart failure. Methods A total of 104 patients with coronary heart disease and heart failure who were admitted to the Department of Cardiology, Jiujiang First People′s Hospital from July 2016 to June 2018 were selected as the research objects, they were divided into control group (52 cases)and observation group (52 cases) according to the random number table method. The control group was treated with Metoprolol, and the observation group was treated with Metoprolol combined with Trimetazidine. The clinical treatment effect, inflammatory factor levels and cardiac function indexes before and after treatment, and total incidence of adverse reactions were compared between the two groups. Results The total effective rate in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). The levels of tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hs-CRP) in the two groups after treatment were lower than those before treatment, the levels of TNF-α, IL-6 and hs-CRP in the observation group after treatment were lower than those in the control group, the differences were statistically significant (P＜0.05). After treatment, the left ventricular ejection fraction (LVEF) in the two groups was higher than that before treatment, the left ventricular endsystolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) were lower than those before treatment,the LVEF after treatment in the observation group was higher than that in the control group, and LVESD and LVEDD were lower than those in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the overall incidence of adverse reactions between the two groups (P＞0.05). Conclusion The treatment of patients with coronary heart disease and heart failure with Metoprolol combined with Trimetazidine can effectively improve the treatment effect, improve cardiac function, and reduce the level of inflammatory factors, which is worthy of clinical application. 2020 Vol. 27 (7): 48-50转54 [Abstract] ( 72 ) HTML (35 KB)  PDF  (0 KB)  ( 13 ) 51 Clinical significance of combined detection of serum amino terminal brain natriuretic peptide precursor and cardiac troponin I in patients with chronic heart failure LIU Ban Objective To investigate the clinical significance of combined detection of serum aminoterminal brain natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI) in patients with chronic heart failure. Methods Fortynine patients with chronic heart failure admitted to our hospital from March to December 2018 were selected as the observation group, and 49 healthy patients in our hospital during the same period were selected as the control group for retrospective analysis. The New York Heart Association (NYHA) cardiac function classification method was used to further divide the observation group into：NYHA Ⅱobservation group(17 cases),NYHA Ⅲobservation group(16 cases),NYHA Ⅳobservation group (16 cases). Both the observation group and the control group received latex-enhanced immunoturbidimetry and antibody sandwich immunoassay. The concentrations of cTnI and NT-proBNP were compared between the two groups. The concentrations of cTnI and NT-proBNP were compared in the NYHA Ⅱ, Ⅲ, and Ⅳobservation groups. The true positive rate of cTnI, NT-proBNP concentration combined detection and single detection in the observation group was compared. Results The cTnI and NT-proBNP in the observation group were higher than those in the control group, the differences were statistically significant (P ＜0.05). The cTnI and NT-proBNP concentrations in the NYHA Ⅱobservation group were lower than those in the NYHA Ⅲand Ⅳobservation group, the differences were statistically significant (P＜0.05). The concentration of cTnI and NT-proBNP in NYHA Ⅳobservation group were higher than those in NYHA Ⅲobservation group, the differences were statistically significant (P＜0.05). The true positive rate of cTnI+NT-proBNP combined detection was higher than that of cTnI and NT-proBNP single detection, and the differences were statistically significant (P＜0.05). In the observation group, the true positive rate of cTnI single detection was lower than that of NT-proBNP single detection, and the difference was statistically significant(P＜0.05). Conclusion The combined detection of serum NT-proBNP and cTnI can effectively improve the detection rate of patients with chronic heart failure, which is worthy of popularization. 2020 Vol. 27 (7): 51-54 [Abstract] ( 77 ) HTML (34 KB)  PDF  (0 KB)  ( 5 ) 55 Clinical effect of intravenous thrombolytic therapy with recombinant tissue-type plasminogen activator on patients within 4.5 hours of the onset of mild ischemic stroke ZHONG Rui Objective To investigate the clinical effect of intravenous thrombolytic therapy with recombinant tissuetype plasminogen activator (Alteplase) on patients within 4.5 hours of the onset of mild ischemic stroke. Methods The clinical data of 60 patients with mild ischemic stroke admitted to our hospital from January 2018 to January 2019 were retrospectively analyzed, and were divided into the control group (n=30) and the Alteplase group (n=30) according to different treatment schemes. The control group was treated with conventional drugs, and the Alteplase group was intervened with Alteplase intravenous thrombolysis. The total effective rate, the national institutes of health stroke scale(NIHSS) score before and after treatment, the Barthel index (BI) score, and the intracranial hemorrhage rate and the incidence of vascular reocclusion after one-week treatment were compared between the two groups. Results The total effective rate of the Alteplase group was higher than that of the control group, the difference was statistically significant(P＜0.05). The NIHSS score of the Alteplase group was lower than that of the control group, and the BI score was higher than that of the control group, the incidence of reocclusion was lower than that of the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the intracranial bleeding rate between the two groups(P＞0.05).Conclusion The application of Alteplase to treat patients with mild ischemic stroke within 4.5 hours of onset can improve neurological deficits, improve daily living ability, and is highly safe. 2020 Vol. 27 (7): 55-57 [Abstract] ( 81 ) HTML (32 KB)  PDF  (0 KB)  ( 15 ) 58 Clinical effect of of thrombolysis with Ateplase in the treatment of acute cerebral infarction MA Ming-hui Objective To explore the clinical effect of of thrombolysis with Ateplase in the treatment of acute cerebral infarction. Methods A total of 90 patients with acute cerebral infarction treated in our hospital from January 1, 2018 to July 1, 2019 were selected as the research object, and divided into study group and control group according to random number table method. Patients in the control group were given conventional treatment such as platelet inhibitor and free radical scavenger, while patients in the study group were treated with Alteplase thrombolysis based on the control group. The levels of inflammatory factors before and after treatment, therapeutic effects and total incidence of adverse reactions after treatment between the two groups were compared. Results There was no significant difference in the level of inflammatory factors before treatment between the two groups (P＞0.05). The levels of high sensitive C-reactive protein (hs-CRP), interleukin-1β (IL-1β) and tumor necrosis factor (TNF-α) in the two groups were lower than those before treatment, the differences were statistically significant (P＜0.05). The levels of hs-CRP, IL-1β and TNF-α in the study group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05). Conclusion Thrombolysis with Ateplase can significantly reduce the level of inflammatory factors in patients with acute cerebral infarction, and improve the therapeutic effect of patients without increasing the adverse reactions of patients, which is worthy of clinical promotion and application. 2020 Vol. 27 (7): 58-60 [Abstract] ( 90 ) HTML (33 KB)  PDF  (0 KB)  ( 13 ) 61 Clinical effect of intracranial pressure monitoring of lateral ventricle puncture for extraventricular drainage in the treatment of intraventricular hemorrhage YANG Ke; CAI Shao-ming; QIU Ping-hua; XIE Le-hui ; LI Han-cheng Objective To explore the clinical effect of intracranial pressure monitoring of lateral ventricle puncture for extraventricular drainage in the treatment of intraventricular hemorrhage. Methods Seventy-seven patients with intraventricular hemorrhage from the First Department of Neurosurgery in Jieyang People′s Hospital of Guangdong Province from July 2017 to December 2018 were selected as subjects. The patients were divided into observation group and control group by database random grouping method, 35 cases in each group. Patients in the observation group were treated with intracranial pressure monitoring of the lower ventricle puncture for extraventricular drainage, and patients in the control group were treated with conventional ventricle puncture drainage. The Mannitol dosage, Mannitol use time and the total incidence of complications were compared between the two groups. The hematoma emptying rates on the first and third day after operation were compared between the two groups. The hematoma residues of the two groups were compared. The Glasgow coma indexes (GCS) before and at 3 and 7 days after operation of the two groups were compared. Results The residual amount of hematoma and the Mannitol dosage in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The Mannitol use time in the observation group was shorter than that of the control group, the difference was statistically significant (P＜0.05). The overall incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The hematoma emptying rates of the observation group on the first and third day after operation were higher than those of the control group, and the differences were statistically significant (P＜0.05). The GCS scores at 3 and 7 days after operation in the observation group were higher than those of the control group, with statistically significant differences (P＜0.05). Conclusion The intracranial pressure monitoring of intracranial pressure in patients with intraventricular hemorrhage is effective in the treatment of lateral ventricle puncture. 2020 Vol. 27 (7): 61-64 [Abstract] ( 80 ) HTML (35 KB)  PDF  (0 KB)  ( 4 ) 65 Clinical effect of Fluoxetine combined with Olanzapine in the treatment of depression with somatic symptoms LIU Hui-ying Objective To investigate the efficacy and safety of Fluoxetine combined with Olanzapine in the treatment of depression with somatic symptoms. Methods Sixty-two patients with depression with physical symptoms who were treated in our hospital from February 2016 to October 2018 were enrolled. The patients were divided into observation group(n=31) and control group (n=31) according to the random number table method. The observation group was treated with Fluoxetine plus Olanzapine, the control group was treated with Fluoxetine alone, and both groups were treated continuously for 8 weeks. Before treatment and at the 2nd, 4th and 8th week of treatment, the Hamilton depression scale(HAMD) and somatic symptom severity scale (PHQ) were used to evaluate the effect. The treatment emergent symptom scale (TESS) was used to evaluate adverse reactions. Results The HAMD and PHQ scores of the observation group were lower than those of the control group at the 2nd, 4th and 8th week of treatment, the differences were statistically significant (P＜0.05). There was no significant difference in TESS score between the two groups (P＞0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). The total effective rate of the observation group was 96.77%, which was higher than that of the control group (80.64%), and the difference was statistically significant (P＜0.05). Conclusion The effect of Fluoxetine combined with Olanzapine in the treatment of depression with somatic symptoms is better than that of Fluoxetine alone, and it takes effect quickly in good safety. 2020 Vol. 27 (7): 65-68 [Abstract] ( 103 ) HTML (37 KB)  PDF  (0 KB)  ( 13 ) 69 Clinical efficacy and safety evaluation of Batroxobin combined with Agatroban in the treatment of acute ischemic stroke ZHANG Jing-xin Objective To explore the clinical efficacy and safety of Batroxobin combined with Agatroban in the treatment of acute ischemic stroke, so as to provide references for clinicians to choose rational drug regimens. Methods A total of 80 patients with acute ischemic stroke admitted to Liaoyang Central Hospital from April 2018 to July 2019 were selected as the study subjects. According to the random number table method, the subjects were divided into the experimental group and the control group, 40 cases in each group. The control group was given routine treatment, and the experimental group was given the combination of Batroxobin and Agatroban based on the control group. The total effective rate of clinical treatment, National Institute of Health stroke scale (NIHSS) score and incidence of adverse reactions were compared between the two groups. Results The total clinical effective rate of the experimental group(92.50%) was higher than that of the control group (75.00%), the difference was statistically significant (P＜0.05). The NIHSS scores of the patients in the two groups after treatment were lower than those before treatment, and the NIHSS score of the experimental group was lower than that of the control group, the differences were statistically significant(P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion In the treatment of patients with acute ischemic stroke, the combination of Batroxobin and Agatroban has ideal clinical effect, and can effectively improve the neurological deficit without increasing adverse reactions, which is worthy of recommendation. 2020 Vol. 27 (7): 69-71 [Abstract] ( 86 ) HTML (31 KB)  PDF  (0 KB)  ( 15 ) 72 Study on the effect of two blood purification methods on maintenance hemodialysis patients with hypertension ZHANG Qing-sheng; WU Jun-gen; YANG Hong-xia Objective To observe the effect of hemoperfusion combined with routine dialysis on maintenance hemodialysis patients with hypertension. Methods A total of 60 patients with maintenance hemodialysis and hypertension admitted to our hospital from May 2017 to January 2019 were selected as the research objects. They were divided into control group (n=30) and observation group (n=30) by even and odd drawing lots, the odd number was drawn as control group and the even number as observation group. The patients in the control group were treated by routine hemodialysis. The observation group was treated with hemoperfusion combined with routine dialysis. The changes of blood pressure, serum C-reactive protein (CRP) and interleukin-6 (IL-6) were compared between the two groups before and after treatment. Results After 4, 8 and 12 weeks of treatment, the diastolic and systolic blood pressures of the patients in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).After 12 weeks of treatment, the levels of CRP and IL-6 in the observation group were lower than those in the control group (P＜0.05). Conclusion Hemoperfusion combined with routine dialysis has a good therapeutic effect on patients with maintenance hemodialysis and hypertension. Compared with routine hemodialysis, hemoperfusion combined with routine dialysis can effectively reduce the blood pressure level of patients with maintenance hemodialysis and hypertension, and has certain influence on the body mineral and bone metabolism indexes of patients. 2020 Vol. 27 (7): 72-74 [Abstract] ( 69 ) HTML (31 KB)  PDF  (0 KB)  ( 12 ) 75 Clinical effect of microscopical varicocele ligation in the treatment of varicocele LUO Jian-bin; ZHU Zheng-bin; FU Li-zhong; LIU Zhong-ping; HUANG Xiao-long; YUAN Guo-ming Objective To investigate the clinical effect of microscopical varicocele ligation in the treatment of varicocele. Methods The clinical data of sixty patients with varicocele admitted to our hospital from November 2017 to February 2019 were retrospectively analyzed. They were divided into experimental group (n=30) and control group (n=30) according to different treatment methods. The experimental group received microscopical varicocele ligation in subinguinal incision, while the control group was treated with retroperitoneal laparoscopic varicocele ligation. The quality of semen before and after treatment and the incidence of complications including scrotal edema, testicular atrophy, epididymitis and hospital stay were compared between the two groups. Results There were no significant differences in sperm count and sperm concentration between the two groups before treatment (P＞0.05). After treatment, the sperm concentration of the experimental group was higher than that of the control group, and the sperm count was more than that of the control group (P＜0.05). The total incidence of complications was lower in the experimental group than that in the control group, the differences were statistically significant (P＜0.05). The hospital stay in the experimental group was shorter than that in the control group (P＜0.05). Conclusion The clinical effect of varicocele ligation under microscope in the treatment of varicocele is remarkable. 2020 Vol. 27 (7): 75-77 [Abstract] ( 81 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 78 Effect of transurethral plasma enucleation combined with Nesbit resection in the treatment of huge benign prostatic hyperplasia WANG Xiao-lin; LI Yong; YAO Shun; YU Xiao-mei; WU Xiu-lian Objective To investigate the effect of transurethral plasma enucleation combined with Nesbit resection in the treatment of huge benign prostatic hyperplasia. Methods Sixty patients with benign prostatic hyperplasia treated in our hospital from January 2018 to July 2019 were selected as research objects, they were divided into control group and observation group according to different treatment methods, 30 cases in each group. Patients in the control group was treated with transurethral plasma enucleation, patients in the observation group was treated with transurethral plasma enucleation and Nesbit resection. The surgical time, intraoperative blood loss, length of hospital stay, residual urine volume before and after treatment, maximum urine flow rate, international prostate symptom scale (IPSS) score, quality of life (QOL) scorebefore and after treatment, total complication rate were compared between the two groups. Results There was no significant difference in the operation time between the two groups (P＞0.05). The intraoperative blood loss of the observation group was less than that of the control group, the length of hospital stay was shorter than that of the control group, the differences were statistically significant (P＜0.05). The residual urine volume in the two groups after treatment was less than that before treatment, and the maximum urine flow rate was greater than that before treatment,the differences were statistically significant (P＜0.05). The residual urine volume of the observation group at 3 months after treatment was less than that of the control group, the maximum urine flow rate was greater than that of the control group, the differences were statistically significant (P＜0.05). The IPSS and QOL scores at 3 months after treatment were lower in the two groups than before treatment, the differences were statistically significant (P＜0.05). The IPSS and QOL scores of the observation group at 3 months after treatment were lower than those of the control group, the differences were statistically significant (P＜0.05). The total incidence of complications in the observation group was 3.33%, which was lower than 26.67% of the control group, the difference was statistically significant (P ＜0.05). Conclusion Transurethral plasma enucleation combined with Nesbit resection for huge benign prostatic hyperplasia can reduce intraoperative blood loss and residual urine volume, shorten the length of hospital stay, increase the maximum urine flow rate, control prostate symptoms, and improve the quality of life of patients, which is worthy of clinical application. 2020 Vol. 27 (7): 78-81 [Abstract] ( 74 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 82 Feasibility of transurethral plasmakinetic resection of prostate treating benign prostatic hyperplasia and its influence on patients′ quality of life LIAO Wei-xuan Objective To analyze the feasibility of transurethral plasmakinetic resection of prostate (TUPKP) treating benign prostatic hyperplasia (BPH) and its influence on the quality of life of patients. Methods A total of 57 patients with BPH who came to our hospital from January 2016 to January 2018 were selected as research objects and divided into the experimental group with 27 cases and the control group with 30 cases by random number table method. The experimental group was treated by TUPKP. The control group was treated with traditional transurethral resection of prostate (TURP). The changes of operation time, intraoperative blood loss, indwelling catheter time, hospitalization time,international prostate symptom score (IPSS), quality of life (QOL) score, maximum urinary flow rate (QMAX), total complication incidence rate and so on were compared between the two groups. Results The operation time of the experimental group was shorter than that of the control group, the difference was statistically significant (P＜0.05), the amount of bleeding in the experimental group was less than that of the control group, the difference was statistically significant(P＜0.05). There were no significant differences in indwelling catheter time, hospitalization time, IPSS, QOL scores and QMAX between the two groups before and one month after operation (P＞0.05). The total incidence of complications in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion TUPKP is effective in the treatment of BPH, especially in improving the quality of life of patients. 2020 Vol. 27 (7): 82-84 [Abstract] ( 75 ) HTML (32 KB)  PDF  (0 KB)  ( 14 ) 85 Clinical effect of transurethral plasma resection of prostate combined with enucleation in the treatment of benign prostatic hyperplasia HU Xiao; ZHOU Qin Objective To explore the clinical effect of transurethral plasma resection of prostate combined with enucleation in the treatment of benign prostatic hyperplasia. Methods A total of 60 patients with benign prostatic hyperplasia treated in our hospital from January to December 2018 were divided into control group (n=30) and study group (n=30)by random number table method. The study group was treated with transurethral plasma resection of prostate combined with enucleation, while the control group was treated with transurethral plasma resection of prostate. The postoperative complications, indexes follow-up for 3 months and safety during operation were compared between the two groups. Results The operation time, bladder washing time, catheter extraction time and postoperative hospitalization time of the patients in the study group were shorter than those in the control group, the amount of bleeding during operation was less than that in the control group, and the weight of resected tissue was higher than that in the control group, the differences were statistically significant (P＜0.05), but there were no significant differences in international prostate symptom score (IPSS), maximum urine flow (Qmax) and residual urine volume (RU) between the two groups (P＞0.05). The total incidence of complications in the study group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Transurethral plasma resection of prostate combined with transurethral enucleation of prostate can effectively improve the safety of operation,significantly reduce the incidence of complications, reduce the recurrence rate and increase the ability of urinary control in patients with benign prostatic hyperplasia. 2020 Vol. 27 (7): 85-87 [Abstract] ( 65 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 88 Effect comparison between continuous blood purification and intermittent hemodialysis in the treatment of acute renal failure WEI Shou-liang Objective To study the effect of continuous blood purification (CRRT) and intermittent hemodialysis (IHD)on electrolyte levels in patients with acute renal failure (ARF). Methods A total of 94 patients with ARF diagnosed and treated in the hospital from January 2017 to March 2019 were divided into observation group and control group by the random number table method with 47 cases in each group. Patients in the control group underwent IHD, and patients in the observation group underwent CRRT. Blood urea nitrogen and serum creatinine levels were compared before and after treatment. Electrolyte abnormalities after treatment and the incidence of complications were compared between the two groups. Results The levels of blood urea nitrogen and serum creatinine in the observation group after treatment were lower than those in the control group (P＜0.05). After dialysis, the proportions of K+, Na+ and Ca2+ electrolyte abnormalities in the observation group were lower than those in the control group (P＜0.05). The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion For patients with ARF, CRRT can better improve blood urea nitrogen and serum creatinine levels,correct electrolyte abnormalities and reduce complications, compared with IHD. It is worthy of application. 2020 Vol. 27 (7): 88-90 [Abstract] ( 54 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 91 Effect of MMC model on blood glucose control and self-management ability in patients with diabetic retinopathy WANG Mian-jiong; LIN Qiu-qiang; CHEN Ting-yang; CHEN Ze-jun Objective To explore the application effect of the national metabolic management center (MMC) model in patients with diabetic retinopathy (DR). Methods A total of 126 patients with DR who were admitted to our hospital from August 2018 to August 2019 were selected as research objects. They were divided into observation group and control group according to the random number table method, with 63 cases in each group. Patients in the control group used the traditional intervention mode, and patients in the observation group added the MMC model on the basis of the control group. The self-management ability and levels of blood glucose indicators (fasting plasma glucose [FPG], 2 hours postprandial blood glucose [2 h PBG], and glycated hemoglobin [HbA1c]) before and after intervention in two groups of patients were compared. Results The compliance rates of blood glucose monitoring, DR knowledge, diet control, regular exercise, foot care, and compliance with the medicines in the observation group were higher than those in the control group, and the differences were statistically significant (χ2=5.143, 4.881, 4.203, 4.148, 4.476, 4.805, P＜0.05). There were no significant differences in the levels of FPG, 2 h PBG, HbA1c before intervention between the two groups of patients (t=0.093, 0.195, 0.603, P＞0.05). The levels of FPG, 2 h PBG, and HbA1c after intervention in the observation group were lower than those in the control group, and the differences were statistically significant (t=9.390, 10.833,6.968, P＜0.05). Conclusion Based on MMC model can improve self-management ability of patients and it is beneficial to blood glucose control. 2020 Vol. 27 (7): 91-94 [Abstract] ( 67 ) HTML (35 KB)  PDF  (0 KB)  ( 13 ) 95 Application of immediate parathyroid autograft in total thyroidectomy WANG Ling； LI Hui-zheng； CUI Ling Objective To investigate the application of immediate parathyroid autograft in total thyroidectomy. Methods Eighty-eight patients with total thyroidectomy admitted in our hospital from July 2017 to April 2019 were selected as the research objects, they were divided into the control group (56 cases) and the observation group (32 cases) according to different surgical methods. The control group used a fine capsule anatomy, the observation group used a fine capsule anatomy+immediate parathyroid autograft. The levels of parathyroid hormone (PTH), blood calcium (Ca) before and after different periods of operation and the damage of parathyroid gland were compared between the two groups. Results There was no significant difference in PTH and blood Ca levels between the two groups before surgery (P＞0.05). At 1,2, and 3 days, 1 week and 1 month after surgery, the PTH and blood Ca levels in the two groups were lower than before surgery, the PTH level in the observation group at 1 day and 1 month after surgery were higher than those in the control group, the levels of blood Ca in the observation group at 1, 2, and 3 days, 1 week and 1 month after surgery were higher than those in the control group, the differences were statistically significant (P＜0.05). The incidence of temporary parathyroid injury in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). There was no significant difference in the incidence of permanent parathyroid injury between the two groups (P＞0.05). Conclusion Immediate parathyroid autograft applied to total thyroidectomy can stabilize PTH and blood Ca levels and reduce the incidence of temporary parathyroid injury. 2020 Vol. 27 (7): 95-97转101 [Abstract] ( 62 ) HTML (35 KB)  PDF  (0 KB)  ( 13 ) 98 Clinical effect of Saxagliptin in the treatment of patients with type 2 diabetes mellitus complicated with metabolic syndrome and its influence on microinflammatory state DENG Ying-yu； LIAO Tie-jun； LIN Yun-shan Objective To investigate the clinical effect of Saxagliptin in the treatment of patients with type 2 diabetes mellitus complicated with metabolic syndrome and its influence on microinflammatory state. Methods A total of 102 patients with type 2 diabetes complicated with metabolic syndrome admitted to our hospital from January 2017 to August 2018 were selected as research objects, and they were divide into conventional group (n=51) and experimental group (n=51) according to the random number table method. The conventional group was treated with Metformin, and the experimental group was treated with Saxagliptin on the basis of conventional group. The clinical efficacy, glycolipid metabolic indicators (fasting plasma glucose [FPG], fasting insulin [FPI], insulin resistance index [HOMA-IR], glycated hemoglobin [HbA1c], triacylglycerol [TG], total cholesterol [TC]), inflammatory factor (tumor necrosis factor-α [TNF-α],interleukin-6 [IL-6], high-sensitivity C-reactive protein [hs-CRP]) contents before and after treatment, and total incidence rate of adverse reactions were compared between the two groups. Results The total effective rate of treatment in the experimental group (94.12%) was higher than that in the conventional group (74.51%), and the difference was statistically significant (P＜0.05). After treatment, FPG, FPI, HOMA-IR, HbA1c, TG, TC, TNF-α, IL-6, and hs-CRP in the two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05). The FPG, FPI, HOMA-IR, HbA1c, TG, TC, TNF-α, IL-6, and hs-CRP in the experimental group after treatment were lower than those in the conventional group, and the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence rate of adverse reactions between the two groups of patients (P＞0.05). Conclusion The effect of Saxagliptin combined with Metformin in the treatment of type 2 diabetes mellitus complicated with metabolic syndrome is obvious, it can reduce the levels of glycolipid and inflammatory factors with application security,which is worth promoting. 2020 Vol. 27 (7): 98-101 [Abstract] ( 60 ) HTML (34 KB)  PDF  (0 KB)  ( 23 ) 102 Clinical effect comparison between laparoscopic and open splenectomy in the treatment of patients with cirrhotic portal hypertension ZENG Wei Objective To investigate and compare the clinical effect between laparoscopic and open splenectomy in the treatment of patients with cirrhotic portal hypertension. Methods A total of 72 patients with cirrhotic portal hypertension who were diagnosed and treated in our hospital from January 2016 to March 2018 were selected as subjects, and divided into the observation group and the control group by the random number table method, with 36 cases in each group. The control group was treated with open splenectomy, while the observation group was treated with laparoscopic splenectomy. The hospitalization indexes, liver function indexes, white blood cells, platelet and curative effect were compared between the two groups. Results The operation time of the observation group was longer than that of the control group, the intraoperative blood loss was less than that of the control group, the visual analogue scale (VAS) score of incision pain was lower than that of the control group, the postoperative time to get up of bed and postoperative hospital stay were shorter than those in the control group, the differences were statistically significant (P＜0.05). On the 1st and 7th day after the operation, the serum alanine aminotransferase (ALT), serum aspartic aminotransferase (AST), serum total bilirubin (TBil) and serum direct bilirubin (DBil) in the observation group were all lower than those in the control group, with statistically significant differences (P＜0.05). The leucocyte and platelet levels in the observation group were higher than those in the control group one month after the operation, with statistically significant differences (P＜0.05).The total effective rate of the observation group was 94.44%, which was higher than that of the control group (77.78%),and the difference was statistically significant (P＜0.05). Conclusion Laparoscopic splenectomy can relieve the pain caused by surgery, reduce the impact on liver function, and protect the immune function of patients. 2020 Vol. 27 (7): 102-105 [Abstract] ( 71 ) HTML (37 KB)  PDF  (0 KB)  ( 13 ) 106 Effect of early plastic surgery in the treatment of hand Ⅱand Ⅲdegree burns LI Yan; WU Xiao-rong; DENG Li-na; WANG Zhi-zhen; ZHANG Ren; CHEN Ai-ping; ZHAN Li-ping Objective To investigate the effect of early plastic surgery in the treatment of hand Ⅱand Ⅲdegree burns. Methods A total of 60 patients with hand Ⅱand Ⅲdegree burns who were treated in Third Hospital of Yingtan City, Jiangxi Province from May 2016 to May 2019 were selected as the research subjects, they were divided into the control group (30 cases) and the observation group (30 cases) according to the single and double grouping method.The control group was treated with delayed repair, the observation group was treated with early plastic surgery. The clinical effect, total incidence of complications, pain score, self-rating anxiety scale (SAS) and self-depressing scale(SDS) scores were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). The pain score of the observation group was lower than that of the control group, the difference was statistically significant (P＜0.05). The scores of SAS and SDS in the observation group were lower than those in the control group,the differences were statistically significant (P＜0.05). Conclusion Early plastic surgery for hand burn patients can improve the treatment effect, reduce the incidence of complications, relieve the degree of pain, anxiety and depression,which is worthy of clinical application. 2020 Vol. 27 (7): 106-108 [Abstract] ( 68 ) HTML (36 KB)  PDF  (0 KB)  ( 13 ) 109 Clinical effect of ultrasound-guided Maimotong minimally invasive resection in the treatment of benign breast tumors XU Shu-yi; HE Jian-ming Objective To explore the clinical effect of ultrasound-guided Maimotong minimally invasive resection in the treatment of benign breast tumors. Methods Eighty female benign breast tumor patients treated in our hospital from January to December 2018 were selected as the research subjects,they were divided into observation group(40 cases) and control group (40 cases) according to the different surgical methods. The control group underwent conventional breast tumor resection, and the observation group underwent ultrasound-guided Maimerton resection. The anxiety selfassessment scale (SAS) and depression self-assessment scale (SDS) scores before and after surgery, surgical indicators,visual analogue scale (VAS) scores, total incidence of complications, wound healing time, and shoulder function were compared between the two groups. Results The SAS and SDS scores in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The operation time in the observation group was shorter than that in the control group, the intraoperative blood loss was less than that in the control group, the length of the surgical scar was shorter than that in the control group, the VAS score was lower than the control group, the differences were statistically significant (P＜0.05). The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). The wound healing time, shoulder joint lifting and weight lifting recovery time in the observation group were shorter than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Ultrasound-guided Maimerton minimally invasive surgery for patients with benign breast tumors can effectively improve the patients′ anxiety and depression, shorten the operation time, wound healing time, shoulder joint lifting and lifting weight recovery time, and surgical scar length, reduce the amount of bleeding, relieve the pain of patients, reduce the incidence of complications, it is worth clinical promotion and application. 2020 Vol. 27 (7): 109-112 [Abstract] ( 76 ) HTML (36 KB)  PDF  (0 KB)  ( 14 ) 113 Clinical effect of ultrasound-guided portal vein puncture guided transjugular intrahepatic portosystemic shunt combined with varicose vein embolization in the treatment of esophageal gastric fundus varices rupture and bleeding LIN Gang-yi; MA Ming-yuan; CAI Zong-yang Objective To explore the clinical effect of ultrasound-guided portal vein puncture guided transjugular intrahepatic portosystemic shunt (TIPS) combined with varicose vein embolization in the treatment of esophageal and gastric fundus varices rupture and bleeding. Methods Sixty patients with esophageal gastric fundus rupture and bleeding who were treated in our hospital from December 2015 to January 2018 were selected as the research subjects, they were divided into observation group (n=30) and control group (n=30) by random number table method. The control group was treated with traditional TIPS pathway combined with percutaneous transhepatic variceal embolization (PTVE),the observation group was treated with ultrasound guided portal vein puncture guided TIPS combined with varicose vein embolization. Surgical indicators, liver vascular conditions, and liver function indexes before and after treatment were compared between the two groups. Results The number of shunt punctures in the observation group was less than that in the control group, the length of the shunt puncture and surgery was shorter than that of the control group, the success rate of shunt punctures was higher than that of the control group, the differences were statistically significant (P＜0.05). The portal vein diameter, splenic vein diameter and hepatic artery flow velocity in the observation group were lower than those in the control group, the portal vein velocity, splenic vein flow velocity and hepatic artery vascular resistance index (RI) were higher than those in the control group, the differences were statistically significant (P＜0.05).The albumin level in the observation group after treatment was higher than that in the control group, the levels of total bilirubin and alanine aminotransferase were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Ultrasound-guided portal puncture-guided TIPS combined with varicose vein embolization for esophageal gastric fundus varicose rupture and bleeding can reduce the number of shunt punctures, shorten the shunt puncture time and the length of surgery, improve the success rate of shunt punctures, and improve the patients′liver and blood vessels and liver function indicators. 2020 Vol. 27 (7): 113-116 [Abstract] ( 58 ) HTML (35 KB)  PDF  (0 KB)  ( 12 ) 117 Effect of different delivery methods on pregnant again pregnancy outcome and neonatal status after cesarean section ZHANG Shan-shan； LIANG Xu-xia; WEI Yan-fen Objective To investigate the effect of different delivery methods on pregnant again pregnancy outcome and neonatal status after cesarean section. Methods A total of 535 cases of pregnant again natural labor after cesarean section who were admitted to our hospital from January 2018 to January 2019 were selected as the research object, they were divided into vaginal trial of second pregnancy after cesarean section (TOLAC) group (182 patients) and the choice of second cesarean section (ERCS) group (353 patients), different delivery methods were selected according to the wishes of the mother. The TOLAC group was divided into the TOLAC success group (135 cases) and the TOLAC failure group (47 cases) according to the final delivery method. The success rate of TOLAC, vaginal assisted delivery, and trial delivery failure to cesarean delivery were recorded. The basic conditions, maternal delivery complications, and neonatal conditions of the three groups were compared; the vaginal trials of the TOLAC group were analyzed. Results The time since previous cesarean section in the ERCS group was longer than that of TOLAC successful group and TOLAC failure group, the differences were statistically significant (P＜0.05). The success rate of TOLAC vaginal delivery was 74.2%(135/182), the vaginal delivery rate was 6.7% (9/135),and the rate of transfer to cesarean section was 25.8%(47/182). There were no significant differences in the amount of postpartum hemorrhage, incidence of serious postpartum hemorrhage, blood transfusion rate, coagulation dysfunction, incomplete uterine rupture, intestinal obstruction, incidence of deep vein thrombosis, birth weight of newborn and incidence of neonatal asphyxia among the three groups (P＞0.05). The incidence rate of tocolytic weakness in the TOLAC success group was lower than that in the TOLAC failure group and the ERCS group, the differences were statistically significant (P＜0.05). The incidence rate of puerperal infection in the TOLAC successful group was lower than that in the ERCS group, the difference was statistically significant (P＜0.05). The incidence rate of chorioamnionitis in the TOLAC failure group was higher than that in the ERCS group, the difference was statistically significant (P＜0.05). Conclusion Under the premise of strictly grasping the indications of TOLAC, it is safe and feasible for vaginal delivery of natural parturients to be pregnant again after cesarean section. The success rate of TOLAC vaginal delivery is more than 70%. Compared with ERCS, TOLAC reduces the incidence of puerperal infections. And shorten the length of hospitalization, have a better outcome of mother and child. The failure of TOLAC increases the incidence of chorioamnionitis, and the mother and infant situation should be closely monitored during the labor process. 2020 Vol. 27 (7): 117-120转124 [Abstract] ( 70 ) HTML (40 KB)  PDF  (0 KB)  ( 16 ) 121 Clinical effect of intratracheal instillation of Bovine Pulmonary Surfactant for Injection combined with Budesonide in the treatment of neonatal respiratory distress syndrome LIU Pan-li; LUO Hong-bin; LIAO Zhi-wei; HU Min; YANG Rui-fen; LIU Wei-yun; HU Yu; XIAO Xiao-xing Objective To study the clinical effect of intratracheal instillation of Bovine Pulmonary Surfactant for Injection combined with Budesonide in the treatment of neonatal respiratory distress syndrome (NRDS). Methods Sixty children with NRDS admitted to the Department of Neonatology of Xinyu People′s Hospital from May 2017 to May 2019 were selected as subjects. They were divided into control group (n=30) and observation group (n=30) by lottery. The control group was treated with Bovine Pulmonary Surfactant for Injection, while the observation group was treated with intratracheal instillation of Bovine Pulmonary Surfactant for Injection combined with Budesonide. The blood gas analysis, clinical manifestations, oxygen saturation (SpO2), heart rate, invasive mechanical ventilation rate, mechanical ventilation time, hospital stay, biparietal diameter (BPD) incidence and total complication rate were observed. Results After treatment, arterial oxygen partial pressure (PaO2) and pH value of the observation group were higher than those of the control group, and mechanical blood carbon dioxide partial pressure ( PaCO2) was lower than that of the control group,the differences were statistically significant (P＜0.05). The scores of clinical manifestations including polypnea, groan,three concave signs, and complexion in the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). The SpO2 in the observation group was higher than that in the control group, and the heart rate was lower than that in the control group, the differences were statistically significant (P＜0.05).In the observation group, the invasive mechanical ventilation rate was lower, the mechanical ventilation time and hospital stay were shorter, and the incidence of BPD and the total incidence of complications were lower compared with those in the control group, the differences were statistically significant (P＜0.05). Conclusion Intratracheal instillation of Bovine Pulmonary Surfactant for Injection combined with Budesonide for children with NRDS can effectively improve blood gas analysis and clinical symptoms, reduce the invasive mechanical ventilation rate, the incidence of BPD and complications, and shorten mechanical ventilation time and hospital stay, which is worthy of promotion. 2020 Vol. 27 (7): 121-124 [Abstract] ( 69 ) HTML (40 KB)  PDF  (0 KB)  ( 13 ) 125 Clinical effect of Goserelin Acetate Sustained-Release Depot combined with laparoscopic surgery in the treatment of endometriosis CHEN Ling-ling; OUYANG Juam Objective To analyze the clinical effect of Goserelin Acetate Sustained-Release Depot combined with laparoscopic surgery in the treatment of endometriosis. Methods Sixty patients with endometriosis treated in our hospital from October 2017 to November 2018 were selected as the subjects, they were divided into treatment group and routine group, with 30 cases in each group. The routine group was treated with laparoscopic surgery, and the treatment group was given Goserelin Acetate Sustained-Release Depot combined with laparoscopic surgery. The total effective rate of treatment and clinical symptoms were compared between the two groups. Results The total effective rate of the treatment group was 93.33%, higher than that of the conventional group (73.33%), and the difference was statistically significant (P＜0.05). After treatment, the pelvic tenderness, dysmenorrhea, irregular menstruation, coital pain and infertility in the treatment group were better than those in the conventional group, and the differences were statistically significant(P＜0.05). The recurrence rate in the treatment group was lower than that in the routine group, and the rate of second pregnancy was higher than that in the routine group, the differences were statistically significant (P＜0.05). Conclusion Goserelin Acetate Sustained-Release Depot combined with laparoscopic surgery can effectively treat endometriosis, and can improve the symptoms of dysmenorrhea, irregular menstruation, sexual pain, infertility, etc., reduce the recurrence rate of endometriosis and improve The rate of pregnancy again is worth promoting. 2020 Vol. 27 (7): 125-127 [Abstract] ( 73 ) HTML (32 KB)  PDF  (0 KB)  ( 16 ) 128 Effect comparison of 5-aminoketovaleric acid photodynamic and Recombinant Human Interferon α-2b Gel in the treatment of cervical high-risk human papilloma virus persistent infection LI Lu Objective To explore the clinical effect and safety of 5-aminolevulinic acid photodynamic therapy and Recombinant Human Interferon α-2b Gel in the treatment of cervical high-risk human papilloma virus (HPV) persistent infection, so as to provide reference for clinicians to select a reasonable treatment plan. Methods A total of 86 patients with cervical high-risk HPV persistent infection diagnosed and treated in Shenyang Madein Women′s and Children′s Hospital from September 2017 to November 2018 were selected as the research objects. They were divided into observation group and control group according to the random number table method, 43 cases in each group. The observation group was treated with 5-aminolevulinic acid photodynamic therapy, while the control group was treated with Recombinant Human Interferon α-2b Gel. The total effective rate of clinical treatment, HPV negative time, symptom disappearance time, inflammatory factor (interleukin-6 [IL-6], interleukin-8 [IL-8], tumor necrosis factor-α [TNF-α]) levels and incidence of adverse reactions were compared between the two groups. Results The total effective rate of clinical treatment in the observation group was 93.02%, which was higher than 74.42% in the control group, and the difference was statistically significant (P＜0.05). The negative time of HPV and the disappearance time of symptoms in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). The levels of inflammatory factors in the observation group after treatment were lower than those in the control group, and the differences were statistically significant (P＜0.05). There were no serious adverse reactions in both groups. Conclusion In the treatment of cervical high-risk HPV persistent infection, both 5-aminolevulinic acid photodynamic therapy and Recombinant Human Interferon α-2b Gel can achieve clinical results and higher safety, but 5-aminolevulinic acid photodynamic therapy has better clinical effect and can promote recovery of patients, which is worth learning. 2020 Vol. 27 (7): 128-130转134 [Abstract] ( 68 ) HTML (34 KB)  PDF  (0 KB)  ( 14 ) 131 Relationship between bone mineral density and serum vitamin A, D and K levels in children with dwarfism PENG Yan Objective To analyze the relationship between bone mineral density and serum vitamin A, D and K levels in children with dwarfism. Methods A total of 73 children with dwarfism consulted and treated in our hospital and 73 normal children with the same age and gender from January 2016 to September 2017 were selected as the case group and the control group respectively, and the height, weight, bone mineral density and serum vitamin A, D and K levels of the children in two groups were measured. The children in the case group were divided into mild bone mineral density deficiency group (27 cases), moderate bone mineral density deficiency group (35 cases) and severe bone mineral density deficiency group (11 cases) according to the bone mineral density Z values, and the relationship between bone mineral density, age and serum vitamin A, D and K levels in the case group was analyzed. Results The height, weight,bone mineral density and vitamin A, D and K levels in the case group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The levels of serum vitamin D and K in the moderate bone mineral density deficiency group and the severe bone mineral density deficiency group were lower than those in the mild bone mineral density deficiency group, and the differences were statistically significant (P＜0.05). The levels of serum vitamin D and K in the severe bone mineral density deficiency group were lower than those in the moderate bone mineral density deficiency group, and the differences were statistically significant (P＜0.05). There were no significant differences in serum vitamin A levels in the children with different bone mineral density deficiency (P＞0.05). Serum vitamin D and K were moderately positively correlated with bone mineral density (r=0.677, 0.659, P＜0.05), and serum vitamin D and K were moderately positively correlated with age (r=0.549, 0.518, P＜0.05). Conclusion Serum vitamin D and vitamin K levels are associated with the bone mineral density in children with dwarfism, the early detection is of great value for the prevention and reduction of low bone mineral density in children with dwarfism. 2020 Vol. 27 (7): 131-134 [Abstract] ( 68 ) HTML (37 KB)  PDF  (0 KB)  ( 14 ) 135 Application effect of Ganirelix Acetate in high risk groups of ovarian hyper-stimulation ZHANG Chu Objective To investigate the effect of Ganirelix Acetate in preventing and treating in vitro assisted pregnancy with ovarian hyper-stimulation syndrome (OHSS). Methods A total of 98 patients with high risk of OHSS who received in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) assisted pregnancy and whole embryo freezing in the Reproductive Medicine Center of Xuzhou Maternal and Child Health Hospital from May 2014 to August 2018 were selected as research objects, they were randomly divided into the control group (48 cases) and the Ganirelix group (50 cases) by the coin toss method. The control group received routine clinical treatment after ovum pick up, and the Ganirelix group received 0.25 mg Ganirelix Acetate once daily for 5 d after ovum pick up on the basis of routine treatment. The occurrence of OHSS and related indexes were compared between the two groups of patients. Results The occurrence of OHSS in the Ganirelix group was better than that in the control group, and the difference was statistically significant (P＜0.05). The hospital stay in the Ganirelix group was shorter than that in the control group, and the difference was statistically significant (P＜0.05). There were no significant differences in occurrence rate of blood concentration, ovarian volume, occurrence rates of abnormal blood clotting and abdominal puncture between the two groups of patients (P＞0.05). Conclusion The use of Ganirelix Acetate after ovum pick up can effectively prevent OHSS. 2020 Vol. 27 (7): 135-138 [Abstract] ( 67 ) HTML (38 KB)  PDF  (0 KB)  ( 16 ) 139 Application effect of hysteroscopy in the diagnosis and treatment of uterine scar pregnancy in cesarean section ZHOU Ting-ting Objective To investigate the effect of hysteroscopy in the diagnosis and treatment of patients with cesarean scar pregnancy (CSP). Methods The clinical data of twenty-four patients with CSP admitted to our hospital from March to October 2018 were analysised, they were divided into two groups according to the different treatment. The control group (n=20) was treated with drug +ultrasound-guided curettage, and the study group (n=4) was treated with uterine artery embolization + hysteroscopic treatment. The intraoperative blood loss and operation time of the two groups of CSP patients were observed and compared. The levels of β-chorionic gonadotropin (β-HCG) and the time required for menses and β-HCG levels to return to normal were compared between the two groups.Results The intraoperative blood loss of the study group was less than that of the control group,and the operation time was shorter than that of the control group, the differences were statistically significant (P＜0.05). The level of postoperative β-HCG in the study group was lower than that in the control group.The recovery time of menstruation and β-HCG level were shorter than those of control group, and the differences were statistically significant (P＜0.05). Conclusion Hysteroscopy can more clearly show the patients′ lesions and its surroundings than ultrasound. Simultaneously, hysteroscopy can reduce the amount of bleeding during surgery and shorten the operation time and recovery time of patients. Hysteroscopy plays a positive guidance in the clinical diagnosis and treatment of CSP pregnancy. 2020 Vol. 27 (7): 139-141 [Abstract] ( 65 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 142 Clinical effect of Desferridone combined with Desferrimide in the treatment of children with severe thalassemia LUO Yu-ting; CHEN Jie; LIANG Da-kai; DAI Ben-qi Objective To investigate the clinical effect of Desferridone combined with Desferrimide in the treatment of children with severe thalassemia. Methods The clinical data of 50 children with severe thalassemia admitted to our hospital from February 2017 to January 2018 were analyzed retrospectively. According to different treatment methods,they were divided into observation group (25 cases) and control group (25 cases). The children in the observation group were treated with Desferridone and Deferoxamine, while the children in the control group were treated with Deferoxamine. The total effective rate, adverse reactions, serum ferritin (SF) and urinary iron excretion were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in SF concentration and urinary iron excretion before treatment between the two groups (P＞0.05). After treatment, the SF concentration in the observation group was lower than that in the control group, and the urinary iron excretion was higher than that in the control group, and the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion The effect of desferridone combined with deferoxamine in the treatment of severe thalassemia is exact, which can reduce the iron load of children and has good safety. It is worthy of popularization and application. 2020 Vol. 27 (7): 142-144 [Abstract] ( 64 ) HTML (34 KB)  PDF  (0 KB)  ( 14 ) 145 Clinical effect of Gamma Globulin as adjuvant treatment for severe adenoviral pneumonia in children ZHOU Ming-jian; CHEN Xiang-jian; ZHUO Xiao-feng; LIU Xue-feng Objective To investigate the clinical effect of Gamma Globulin as adjuvant treatment for severe adenoviral pneumonia (SAP) in children. Methods The clinical data of 150 inpatients with SAP admitted in our hospital from May 2013 to May 2018 were retrospectively analyzed, they were divided into the Gamma Globulin group (75 patients) and the control group (75 patients)based on whether or not gamma globulin was used during treatment.The Gamma Globulin group was treated with adjuvant Gamma Globulin, the control group was treated with conventional therapy. The treatment effect, fever time, hospital stay, mechanical ventilation time, total incidence of adverse reactions and mortality were compared between the two groups. Results The total effective rate of the Gamma Globulin group was higher than that of the control group, the difference was statistically significant (P＜0.05). The fever time, hospitalization time, and mechanical ventilation time of the Gamma Globulin group were shorter than those of the control group, the differences were statistically significant (P＜0.05). There were no significant differences in the total incidence and mortality of adverse reactions between the two groups(P＞0.05).Conclusion Gamma Globulin adjuvant treatment of children SAP can improve the treatment effect of patients, shorten the fever time, hospitalization time and mechanical ventilation time of patients, without increasing the adverse reactions and mortality of the patients, which is worthy of clinical promotion and application. 2020 Vol. 27 (7): 145-147 [Abstract] ( 67 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 148 Effect of painless delivery technology on delivery process and pregnancy outcome LI Xiang Objective To explore the effect of painless delivery technology on the delivery process and pregnancy outcome. Methods A total of 585 primiparous women who gave birth in our hospital from March 2018 to March 2019 were selected as research objects,they were divided into observation group(n=285)and control group(n=300)according to different delivery techniques. Puerper in the observation group performed painless labor, while those in the control group performed routine labor. The pain score, the time of labor, the rate of cesarean section, the amount of postpartum hemorrhage and the incidence of neonatal asphyxia were compared between the two groups. Results The pain scores of the observation group during delivery and suture wounds were lower than those of the control group, the differences were statistically significant(P＜0.05).There were no significant differences in the first,second,and third stage of labor between the two groups (P＞0.05). The cesarean section rate in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). There were no significant differences in postpartum hemorrhage and neonatal asphyxia between the two groups(P＞0.05).Conclusion Painless delivery technology can obviously reduce the pain of parturient and suture wound, reduce the rate of cesarean section, at the same time, it will not affect the delivery process, and will not increase the risk of postpartum hemorrhage and neonatal asphyxia. It is worthy of clinical application. 2020 Vol. 27 (7): 148-150 [Abstract] ( 74 ) HTML (31 KB)  PDF  (0 KB)  ( 12 ) 151 Effect of Remifentanil combined with Propofol on painless gastroscopy anesthesia HAN Lei Objective To observe the clinical effect of Remifentanil combined with Propofol on painless gastroscopy anesthesia. Methods A total of 100 patients who underwent painless gastroenteroscopy and treatment in our hospital from October 2017 to August 2018 were selected. According to the random numer table method, they were divided into two groups with 50 patients in each group. Group A (experimental group) was anesthetized with Remifentanil 0.3-0.5 μg/kg combined with Propofol. Group B (control group) was given Propofol 1.5-2.0 mg/kg to complete the operation. The mean arterial pressure, heart rate, Propofol dosage, gastroenteroscopy time, waking time, anesthetic effect, and adverse reactions of the two groups were observed and compared. Results There were no significant differences in mean arterial pressure and heart rate between the two groups (P＞0.05). Propofol dosage in group A was less than that in group B,with statistically significant difference(P＜0.05).The recovery time of patients in group A was shorter than that in group B,the difference was statistically significant (P＜0.05). There was no significant difference between the two groups in gastrointestinal endoscopy and the time of patients leaving hospital after awake (P＞0.05). The excellent rate of anesthesia effect in group A was higher than that in group B, the difference was statistically significant (P＜0.05). The occurrence rate of respiratory depression in group A was lower than that in group B, the difference was statistically significant (P＜0.05). There was no significant difference in the occurrence rate of postoperative nausea, vomiting, vertigo between the two groups (P＞0.05). Conclusion Remifentanil combined with Propofol for painless gastrointestinal endoscopy anesthesia reduces the dosage of Propofol, shortens the recovery time of patients, has fewer adverse reactions, and is safe and effective in clinical use. 2020 Vol. 27 (7): 151-153转157 [Abstract] ( 74 ) HTML (34 KB)  PDF  (0 KB)  ( 13 ) 154 Anesthetic effect comparison of Sevoflurane inhalation anesthesia with Propofol intravenous anesthesia in elderly patients undergoing laparoscopic cholecystectomy LI Jun-shi Objective To compare the anesthetic effect of Sevoflurane inhalation anesthesia and Propofol intravenous anesthesia in elderly patients with laparoscopic cholecystectomy. Methods A total of 100 elderly patients undergoing laparoscopic cholecystectomy in our hospital from February 2018 to February 2019 were selected as the research subjects, and they were divided into control group (n=50) and research group (n=50) by random number table method. Patients in the control group were provided with Propofol anesthesia, and patients in the research group were anesthetized with inhalation of Sevoflurane. The anesthetic effect of the two groups were compared. The postoperative anaesthesia recovery, extubation and recovery time of the two groups were compared. The mini-mental state examination scale(MMSE) scores of the two groups were compared at different time points after operation. Visual analogue scale (VAS)scores were compared between the two groups at different time points after surgery. Results The excellent anesthesia rate of patients in the research group was 98.00%, which was higher than that in the control group (76.00%), the difference was statistically significant (P＜0.05). The postoperative anesthesia recovery time of patients in the research group was (16.85±3.05) min, the post-extubation time was (23.50±3.80) min, and the post-operative recovery time was(23.65±4.70) min, which were shorter than those of the control group ([20.65±3.55], [27.85±4.65], [27.95±4.80] min),the differences were statistically significant (P＜0.05). The MMSE score at 1 h postoperatively of the patients in the research group was (28.35±0.35) points, the MMSE score at 4 h postoperatively was (27.45±1.25) points, and the MMSE score at 12 h postoperatively was (27.85±1.15) points, which were higher than those in the control group ([22.95±2.50],[23.85±1.40], [25.95±1.20] points), the differences were statistically significant (P＜0.05). There was no significant difference in MMSE scores between the research group and the control group at 24 and 48 h postoperatively (P＞0.05). In the research group, the VAS score score at 1 h postoperatively was (1.25±0.40) points, the VAS score score at 4 h postoperatively was (2.15±0.55) points, the VAS score score at 12 h postoperatively was (2.15±0.45) points, the VAS score score at 24 h postoperatively was (1.88±0.60) points, and the VAS score score at 48 h postoperatively was (1.45±0.55) points, which were not displayed statistical significance compared with the control group ([1.23±0.45], [2.09±0.60], [2.19±0.40], [1.93±0.55], [1.48±0.50] points), respectively (P＞0.05). Conclusion Compared with Propofol intravenous anesthesia, the effect of Sevoflurane inhalation anesthesia in elderly patients undergoing laparoscopic cholecystectomy is remarkable. 2020 Vol. 27 (7): 154-157 [Abstract] ( 70 ) HTML (37 KB)  PDF  (0 KB)  ( 13 ) 158 Application effect of brachial plexus combined with superficial cervical plexus block anesthesia in patients undergoing clavicular fracture surgery PENG Yue Objective To investigate the effect of brachial plexus combined with superficial cervical plexus block anesthesia in patients undergoing clavicular fracture surgery. Methods From January 2017 to December 2018, 36 patients with clavicular fracture treated in department of orthopaedic in our hospital were selected as observation objects. They were divided into control group (18 cases) and experimental group (18 cases) with different operative anesthesia methods. The control group was treated with simple superficial cervical plexus block anesthesia, and the experimental group was treated with brachial plexus block anesthesia combined with superficial cervical plexus block anesthesia. Diastolic blood pressure, heart rate, oxygen saturation and other vital signs after anesthesia were compared between the two groups. The anesthetic effect of the two groups were compared. Results The vital signs such as diastolic blood pressure,heart rate and oxygen saturation in the experimental group were lower than those in the control group 15 minutes after anesthesia, the differences were statistically significant (P＜0.05). At the same time, the diastolic blood pressure, heart rate and oxygen saturation of patients in the two groups were all higher 15 min after anesthesia than that before anesthesia in the two groups, with statistically significant differences (P＜0.05). The excellent and good rate of operation anesthesia in the experimental group was higher than that in the control group, with statistical difference (P＜0.05).Conclusion The brachial plexus combined with superficial cervical plexus block anesthesia for clavicular fracture patients can achieve ideal anesthetic effect, and the safety of anesthesia is high, so it has the value of popularization and application. 2020 Vol. 27 (7): 158-160 [Abstract] ( 60 ) HTML (31 KB)  PDF  (0 KB)  ( 16 ) 161 Value of multi-slice spiral CT enhanced scan in evaluating preoperative TNM staging of stomach cancer LIU Zhen-hua Objective To investigate the value of multi-slice spiral CT (MSCT) enhanced scan in evaluating preoperative TNM staging of stomach cancer (SC). Methods A retrospective analysis was performed among 50 inpatients with SC who were diagnosed by surgery and histopathology in our hospital from January 2017 to May 2019. One senior chief physician and two deputy chief physicians formed a team for diagnosing preoperative TNM staging of SC. TNM staging of SC was carried out according to the results of preoperative findings of MSCT enhanced scan. With postoperative histopathological diagnosis as the golden standard, preoperative TNM staging by MSCT and pathological diagnosis of TNM staging were statistically analyzed. Results The accuracy rates of MSCT for T staging, N staging and M staging were 72.00%, 80.00% and 96.00%, respectively. The corresponding Kappa values were 0.612, 0.590 and 0.883, respectively. Conclusion MSCT enhanced scan can be usd to observe the imaging from multiple angles of the rotation axis. It can accurately diagnose the degree of SC infiltration and lymph node metastasis. It can be used as an effective method for preoperative TNM staging of SC, and provide a basis for clinical surgical treatment. 2020 Vol. 27 (7): 161-163 [Abstract] ( 80 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 164 Comparison of clinical value between CT and MRI in the diagnosis of acute craniocerebral injury HE Bin； YANG Hai-xiang； WU Qin Objective To compare the clinical value of CT and MRI in the diagnosis of patients with acute craniocerebral injury.Methods Sixty-five patients with acute craniocerebral injury admitted to our hospital from December 2017 to June 2019 were selected as the subjects. All patients were given CT and MRI to analyze the imaging findings. The detection rate of acute craniocerebral injury and hematoma thickness detection coincidence rate were compared between the two examinations. The apparent diffusion coefficient (ADC) level at mild and severe region of interest (ROI) was assessed using MRI. Results The total detection rate of acute craniocerebral injury by MRI was 89.23%, higher than that of CT accounting for 66.15%. The detection rates of MRI on subarachnoid hemorrhage and skull fracture were lower than those of CT, and the detection rates of MRI on cerebral contusion, deep contusion, middle and posterior fossa injury, gray matter junctional zone injury and corpus callosum injury were higher than those of CT, with statistical significance (P＜0.05). The coincidence rate of MRI on hematoma thickness was 87.69%, higher than that of CT accounting for 64.62%,with statistical significance(P＜0.05).There was no significant difference in the detection rate of subdural hematoma between the two methods (P＞0.05). The level of ADC in the knee of hydrazine callosum and the back of cerebral foot in the patients with moderate and severe injury was higher than that in the patients with mild injury, and the level of ADC in the front limb of internal capsule and the right side of cerebral foot was lower than that in the patients with mild injury, with statistical significance (P＜0.05). Conclusion Compared with conventional CT, MRI is of high value for the diagnosis of acute craniocerebral injury. The detection rates of lesions and special affected parts are high. 2020 Vol. 27 (7): 164-166转170 [Abstract] ( 78 ) HTML (33 KB)  PDF  (0 KB)  ( 16 ) 167 Application value of contrast-enhanced ultrasound in the diagnosis of tubal-derived infertility LIN Qiang-ji Objective To investigate the application value of contrast-enhanced ultrasound in the diagnosis of tubalderived infertility. Methods Seventy-seven patients with suspected tubal-derived infertility (146 oviducts) admitted to our hospital from February 2018 to July 2019 were enrolled in the study. All patients were diagnosed by contrast-enhanced ultrasound and laparoscopic fluid drainage, and the clinical "gold standard" was based on the diagnosis result of laparoscopic drainage. The sensitivity, specificity and accuracy of contrast-enhanced ultrasound in the diagnosis of tubal infertility were compared. Results The sensitivity of contrast-enhanced ultrasound in the diagnosis of tubal-derived infertility was 100.00% (109/109), specificity was 91.89% (34/37), and accuracy was 97.95% (143/146). Conclusion Contrast-enhanced ultrasound has a high application value in the diagnosis of tubal-derived infertility, which is of high accuracy, safety and reliance, and it is worthy of clinical application. 2020 Vol. 27 (7): 167-170 [Abstract] ( 60 ) HTML (33 KB)  PDF  (0 KB)  ( 16 ) 171 Diagnostic value of digital radiography examination in patients with pulmonary tuberculosis YU Qing-song Objective To explore the diagnostic value of digital radiography (DR) examination in patients with pulmonary tuberculosis. Methods A total of 120 patients with pulmonary tuberculosis patients who were admitted to our hospital from January 2017 to February 2019 and confirmed by sputum bacterial smear examination were selected as the study subjects. All patients underwent DR examination and traditional X-ray examination. The quality of the DR examination was analyzed, the DR examination and the traditional X-ray examination results were compared, the results before and after the DR image processing were analyzed. Results The waste images rate of DR examination was lower than that of traditional X-ray examination, and the grade A images examination rate and the imaging manifestation rate of tuberculosis of DR examination were higher than those of traditional X-ray examination, the differences were statistically significant (P＜0.05). The accuracy of DR examination for intrapulmonary nodules, bronchial grading(leaf bronchus), small holes in the lung (＜1 cm) and intrapulmonary calcifications were 59.17%, 85.00%, 52.50% and 19.17%, which were higher than the 45.83%, 43.33%, 32.50% and 10.00% of traditional X-ray examination, the differences were statistically significant (P＜0.05). The accuracy of bronchiectasis detection after DR image processing was 6.67%, which was higher than the 0.83% before processing, the difference was statistically significant (P＜0.05). There was no significant difference in the accuracy of pleural thickening, bronchial dissemination, hilar lymphadenopathy,pleural effusion, small calcification in the lesion before and after DR image processing (P＞0.05). Conclusion The accuracy of DR examination for diagnosis of tuberculosis is higher than that of traditional X-ray examination, and it has the advantages of simple operation and low waste rate of DR technology, and has powerful image post-processing function.After image processing, the detection rate of bronchiectasis significantly improved, it can be used as a common means of screening tuberculosis. 2020 Vol. 27 (7): 171-174 [Abstract] ( 68 ) HTML (35 KB)  PDF  (0 KB)  ( 11 ) 175 Intervention effect analysis of clinical pharmacist reviewing on the unreasonable medical prescriptions of anti-tumor drugs in the vein configuration center WEN Jian-kun; HUANG Xiang-zhen; ZHEN Ju-quan Objective To analyze the intervention effect of clinical pharmacist reviewing on the unreasonable medical prescriptions of anti-tumor drugs in the vein configuration center. Methods The clinical drug system and hospital information system (HIS) were retrospectively analyzed. The anti-tumor drugs for inpatients in our hospital from January to June in 2018 were used to calculate the irrational use of drugs, as data before intervention. From July to December in 2018, clinical pharmacists participated in the medical reviewing, intervened when there were unreasonable medical prescriptions, and recorded the irrational use of drugs as data after intervention. The data obtained in the hospital throughout the year were statistically analyzed to compare the unreasonable medical prescriptions change of anti-tumor drugs before and after intervention and the effect of pharmacist intervention. Results The unreasonable rate of medical prescription after intervention was 3.28%, which was lower than 8.78% before intervention, with statistically significant difference (P＜0.05). There were statistically significant differences in the unreasonable rates of medical prescriptions of gynecology, otolaryngology, oncology, hepatobiliary gastrointestinal surgery, and thoracic surgery departments before and after intervention (P＜0.05). There were no significant differences in the unreasonable rates of medical prescriptions of radiotherapy and other departments before and after intervention (P＞0.05). Conclusion There are varied degrees of unreasonable medical prescriptions in different departments. Intervention by clinical pharmacists can effectively reduce the incidence of unreasonable anti-tumor drugs and avoid or reduce the incidence of adverse drug reactions. 2020 Vol. 27 (7): 175-177 [Abstract] ( 63 ) HTML (28 KB)  PDF  (0 KB)  ( 10 ) 178 Clinical effect of high-load dose of Teicoplanin in the treatment of Methicillin resistant Staphylococcus aureus pneumonia ZHANG Zhi-hui； FENG Yu-shan； LI Kong-zheng3 Objective To analyze the clinical effect of high-load dose of Teicoplanin in the treatment of Methicillin resistant Staphylococcus aureus (MRSA) pneumonia. Methods A total of 252 patients with pneumonia infected with MRSA in Yangjiang People′s Hospital from January 2017 to December 2018 were selected as research subjects, they were divided into a high-load dose group (n=126) and a low loading dose group (n=126) according to the random number table method. Patients in the high-load dose group received high-load Teicoplanin treatment, patients in the low-load dose group received low-load Teicoplanin treatment. The pulmonary inflammatory exudation lesion absorption, clinical treatment effect, bacterial clearance, body temperature (T) and inflammatory indexes before and after treatment were compared between the two groups. Results The absorption of pulmonary inflammatory exudation lesions in the highload dose group was better than that in the low-load dose group, the difference was statistically significant (P＜0.05).The total effective rate of treatment in the high-load dose group was 95.2%, which was higher than 79.4% in the lowload dose group, the difference was statistically significant (P＜0.05). The total bacterial clearance rate of the high-load dose group was 89.7%, which was higher than 64.3% of the low-load dose group, the difference was statistically significant (P＜0.05). The C-reactive protein (CRP) and white blood cell count (WBC) of the high-load dose group were lower than those of the low-load dose group, the differences were statistically significant (P＜0.05). Conclusion Treatment of MRSA-infected pneumonia with high-load dose Teicoplanin can improve the absorption, treatment effect, and bacterial clearance of inflammatory exudation lesions in the lungs, and reduce the inflammatory index of patients. 2020 Vol. 27 (7): 178-180转184 [Abstract] ( 72 ) HTML (32 KB)  PDF  (0 KB)  ( 12 ) 181 Effect of Yifei Decoction in the treatment of chronic bronchial pneumonia NIU Li-dong； HAI Jiang Objective To investigate the effect of Yifei Decoction in the treatment of chronic bronchial pneumonia.Methods A total of 50 patients with chronic bronchial pneumonia who were treated in Fuxin Trauma Emergency Hospital of Liaoning Province from March 2014 to July 2019 were selected as the research subjects, and they were divided into the control group and the observation group according to the random number table method, with 25 cases in each group. The control group was treated with Western medicine, and the observation group was treated with Yifei Decoction on the basis of the control group. The clinical efficacy, traditional Chinese medicine syndrome scores, inflammatory factors(interleukin-2[IL-2],interleukin-4[IL-4],interleukin-10[IL-10], interferon-γ [IFN-γ]) and levels of pulmonary function indicators (forced expiratory volume in the first second [FEV1], peak expiratory flow [PEF], FEV1 occupying forced vital capacity [FEV1/FVC]) before and after treatment were compared in the two groups. Results The total effective rate of treatment in the observation group was 92.00%, which was higher than 68.00% in the control group, and the difference was statistically significant (P＜0.05). The traditional Chinese medicine syndrome score of patients in the observation group after treatment was (3.42±0.78) points, which was lower than that in the control group for (6.57±0.93)points, and the difference was statistically significant (P＜0.05). The IL-2 level after treatment in the observation group was (50.82±5.74) pg/ml, the IFN-γ level was (28.96±4.52) pg/ml, which were higher than those in the control group for(41.26±5.38) and (24.87±2.16) pg/ml, and IL-4 level was (34.80±3.79) pg/ml, IL-10 level was (23.50±3.53) pg/ml,which were lower than those in the control group for (39.58±4.12) and (29.42±4.35) pg/ml, the differences were statistically significant (P＜0.05). After treatment, the FEV1 in the observation group was (1.98±0.62) L, the PEF was (65.37±6.28) L/min, and the FEV1/FVC was (63.27±6.42)%, which were higher than those in the control group for (1.67±0.33) L,(58.42±5.83) L/min, (57.48±6.15)%, the differences were statistically significant (P＜0.05). Conclusion Yifei Decoction can effectively improve the inflammatory factors and pulmonary function of patients with chronic bronchial pneumonia.The clinical efficacy is exact and it is worthy of popularization and application. 2020 Vol. 27 (7): 181-184 [Abstract] ( 66 ) HTML (39 KB)  PDF  (0 KB)  ( 10 ) 185 Clinical effect of Vancomycin in the treatment of severe pneumonia infected by Gram-positive cocci LI Jing； DING Jin-feng； XIAO Wen-xiang Objective To study the clinical effect of Vancomycin in the treatment of severe pneumonia infected by Gram-positive cocci. Methods Eighty patients with severe pneumonia infected by Gram-positive cocci treated in our hospital from April 2016 to March 2019 were selected as the study subjects. The patients were divided into the control group and the observation group according to the random number table method, with 40 cases in each group. Patients in the control group were treated with Levofloxacin, and in the observation group, patients were treated with Vancomycin. The therapeutic effects, bacterial clearance rate, and adverse reactions in two groups after treatment were compared. Results The total effective rate of the observation group was 95.00%, which was higher than that of the control group accounting for 75.00%, and the difference was statistically significant (P＜0.05). The total bacterial clearance rate of the observation group was 95.00%, which was higher than that of the control group accounting for 75.00%, with statistical significance (P＜0.05). The total incidence of adverse reactions in the observation group was 5.00%, which was lower than that in the control group accounting for 22.5%, with statistical significance (P＜0.05). Conclusion Vancomycin is effective in the treatment of severe pneumonia caused by gram-positive cocci. It is safe and effective, which has less adverse reactions. 2020 Vol. 27 (7): 185-187 [Abstract] ( 69 ) HTML (32 KB)  PDF  (0 KB)  ( 13 ) 188 Study on epidemiological characteristics and risk factors of hypertension in residents of Tumshuk City in Xinjiang ZHANG Shao-xin； WANG Kun-peng； ZHAO Li-zhi； LI De-yun； CHEN Ge Objective To analyze the epidemiological characteristics and related risk factors of hypertension in residents of Tumushuk City, Xinjiang, and to provide a scientific basis for the formulation of hypertension control policies.Methods A cluster random sampling method was used to select 1271 people from 6 regiments in Tumushuk City, Xinjiang from June 2014 to May 2016, Residents aged 18 and above were used as the survey objects, hypertensive patients and their demographic characteristics among residents of Tumushuk city, Xinjiang were counted, the main health problems and behavioral influencing factors of hypertension patients in Tumushuk City, Xinjiang were analyzed, multivariate analysis of risk factors for hypertensive patients in Tumshuk city, Xinjiang were analyzed. Results A total of 1271 permanent residents aged 18 years and over were investigated, and 250 patients with hypertension (19.7%). There were statistically significant differences in the prevalence of hypertension among different ages, marital status, education level, and occupation (P＜0.05). There were statistically significant differences in the prevalence of hypertension with different weights and medical insurance, whether with diabetes, dyslipidemia, and moderate and mild activity (P＜0.05).Logistic regression analysis showed that different ages, occupations, weights, medical insurance, whether dyslipidemia and moderate-intensity activities were independent risk factors for hypertension (P＜0.05). Conclusion The prevalence of hypertension in Tumushuk City, Xinjiang is relatively high and it is more prevalent in different populations. Different ages, occupations, weights, medical insurance, whether dyslipidemia and moderate-intensity activities are independent risk factors for patients with hypertension In order to ensure the effectiveness of prevention and control,key intervention measures should be taken according to the characteristics and risk factors of hypertension. 2020 Vol. 27 (7): 188-191转200 [Abstract] ( 76 ) HTML (39 KB)  PDF  (0 KB)  ( 14 ) 192 Effect of institutional structured education combined with family rehabilitation training model on the parental pressure of autistic children′s mothers LUO Liu-mei; CHEN Bing; HUANG Cui-mei; YING Qiu-xia Objective To study the effect of institutional structured education combined with family rehabilitation training model on the parental pressure of autistic children′s mothers. Methods From January 2018 to January 2019,60 mothers who were initially diagnosed as autistic children in department of child rehabilitation of our hospital were selected, and divided into control group and experimental group according to the random number table method, with 30 cases in each group. The children in control group was given institutional structured education, and the children in experimental group was given institutional structured education combined with family rehabilitation training mode. Six months after the intervention, the parental pressure of the two groups were assessed with the simple parental stress index(PSI-SF),perceived social support scale(SSRS),self rating depression scale(SDS)and self rating anxiety scale(SAS).Results After intervention, the scores of parent-child interaction disorder, resignation distress, children with difficulties and the total score of parental pressure in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05). The scores of subjective support, objective support and social support of mothers in the experimental group were higher than those in the control group, the differences were statistically significant (P＜0.05). The scores of SAS and SDS of mothers in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Institutional structured education combined with family rehabilitation training mode can effectively reduce the parental pressure of autistic children′s mothers and improve the negative emotions of autistic children′s mothers, which is worth popularizing in clinical practice. 2020 Vol. 27 (7): 192-194 [Abstract] ( 82 ) HTML (31 KB)  PDF  (0 KB)  ( 9 ) 195 Application of targeted comprehensive nursing in anesthesia recovery of patients undergoing gynecological laparoscopy FANG Hui-ping Objective To explore the application of targeted comprehensive nursing in the anesthesia recovery of patients undergoing gynecological laparoscopic surgery. Methods Eighty patients undergoing gynecological laparoscopic surgery in anesthesia recovery from June 2017 to December 2018 in our hospital were selected as the research subjects.They were divided into reference group (n=40) and experimental group (n=40) according to the random number table method. In the reference group, basic nursing intervention was used, and in the experimental group, targeted comprehensive nursing intervention was adopted. The clinical nursing satisfaction, incidence of agitation and hypoxemia, heart rate, diastolic blood pressure, systolic blood pressure, and anxiety scores of the two groups were compared. Results The total satisfaction of the patients in the experimental group was higher than that of the reference group, the heart rate,diastolic blood pressure, systolic blood pressure, and anxiety scores were lower than those of the reference group, the degree of agitation was less than the reference group, the incidence of hypoxemia was lower than the reference group with statistical differences (P＜0.05). Conclusion The application of targeted comprehensive nursing intervention in gynecological laparoscopic surgery during anesthesia recovery can reduce the incidence of agitation and improve adverse mood and blood pressure. 2020 Vol. 27 (7): 195-197 [Abstract] ( 86 ) HTML (33 KB)  PDF  (0 KB)  ( 5 ) 198 Application effect of perioperative nursing model in the treatment of complex pelvic and acetabular fractures by pararectus abdominis approach LI Ning; XIONG Shu-hong; CHEN Si; YANG Yan-hong; WANG Yang; ZHANG Yun-hao Objective To evaluate the perioperative nursing value of trans-abdominal rectus approach for the treatment of complex pelvic acetabular fractures. Methods Thirty patients with complex pelvic acetabular fractures treated in our hospital from May 2016 to May 2019 were selected. They were divided into observation group (n=15) and control group(n=15) by central random method. The two groups were treated by pararectus abdominis approach. The observation group received perioperative nursing, while the control group received routine health guidance. Nursing satisfaction,hospitalization time, functional score and incidence of complications were compared. Results The nursing total satisfaction of the observation group was higher than that of the control group, with statistical difference (P＜0.05). The hospitalization time of the observation group was shorter than that of the control group, and the hip function score was higher than that of the control group, with statistical differences (P＜0.05). The total incidence of complications of the observation groups was lower than that of the control group, with statistical difference (P＜0.05). Conclusion Patients with complicated pelvic acetabular fractures treated with transabdominal rectus approach, combined with nursing intervention,are conducive to the improvement of satisfaction, the reduction of the incidence of complications, it has clinical promotion value. 2020 Vol. 27 (7): 198-200 [Abstract] ( 61 ) HTML (31 KB)  PDF  (0 KB)  ( 11 ) 201 Application effect of rapid rehabilitation surgical nursing in ureteral soft mirror surgery LIU Quan-di; CHEN Cai-feng; LI Jian-ping; MO Yan-yan▲ Objective To explore the application effect of rapid rehabilitation surgery (FTS) nursing in soft ureter surgery. Methods A total of 118 patients for soft ureter surgery admitted to our hospital from March 2017 to August 2018 were selected and divided into experimental group (n=58) and control group (n=58) by random drawing. The experimental group was treated with FTS nursing, while the control group was treated with traditional surgical nursing.The complications, the days of indwelling catheter, the cost of hospitalization, visual analogue scale (VAS), the psychological state of (including self-rating anxiety scale [SAS] score and self-rating depression scale [SDS] score) and satisfaction were compared between the two groups. Results The indwelling time of catheter in the experimental group was(27.64 ±8.16) h, and the postoperative hospital stay was (2.32±0.47) d, which were shorter than those in the control group ([78.48±13.92] h, (4.21±0.91) d, and the differences were statistically significant (P＜0.05). The VAS score of the experimental group was (2.54±1.22) points, which was lower than that of the control group (4.48±1.69) points, and the difference was statistically significant (P＜0.05). The hospital satisfaction of the experimental group was (98.95±4.27)%,which was higher than the control group (93.03±8.21)%, and the difference was statistically significant (P＜0.05). There was no significant difference in SAS and SDS score between the two groups before nursing (P＞0.05). The SAS and SDS score of the two groups after nursing were lower than those before nursing, and there was significant difference between the two groups (P＜0.05). The scores of SAS and SDS in the experimental group were (37.05±1.05) and (37.25±1.05)points, respectively， which were significantly lower than those in the control group of (47.85±1.15) points and (48.65±1.15) points, the differences were statistically significant(P＜0.05). The incidence of complications in the experimental group was 8.62%, which was lower than that in the control group (22.41%), the difference was statistically significant (P＜0.05). The total satisfaction of clinical nursing in the experimental group was 96.55%, which was higher than that in the control group (77.59%), the difference was statistically significant (P＜0.05). Conclusion FTS nursing model can reduce the complications, promote the rapid recovery of the patients, reduce the pain, improve the satisfaction of the patients and benefit the patients. It is a nursing technique worth popularizing in order to reduce the complications, promote the rapid recovery of the patients, reduce the pain of the patients, improve the satisfaction of the patients, and benefit the patients. 2020 Vol. 27 (7): 201-204 [Abstract] ( 77 ) HTML (38 KB)  PDF  (0 KB)  ( 12 ) 205 Application effect of holistic nursing in the perioperative period of cicatricial uterus pregnancy resected cesarean section LI Dong-hong; QIN Fu-jie; XU Shao-fen; SU Yue-ying Objective To explore the effect of holistic nursing on the parturient women in the perioperative period of second cesarean section of scar pregnancy. Methods Sixty-two women with scar uterine pregnancy who underwent cesarean section in our hospital from August 2018 to May 2019 were enrolled. According to the random number table method, they were divided into the conventional group and the whole group, 31 cases in each group. Routine nursing was performed in the routine group, and the whole group of women were given holistic nursing based on routine nursing. Perioperative conditions of the two groups of women, Apgar scores and body weight and postoperative complications of the mothers were observed at 1 and 5 min after birth. Results There was no significant difference in operative time and intraoperative blood loss between the two groups (P＞0.05). There was no significant difference in Apgar scores and body weight between the two groups at 1 and 5 min after birth (P＞0.05). The postoperative anal exhaust time and postoperative catheter removal time of the whole group were shorter than those of the conventional group, the difference was statistically significant (P＜0.05), And the incidence of postoperative complications was lower than that of the conventional group, the difference was statistically significant (P＜0.05). Conclusions The holistic nursing of the parturient women after cesarean section can promote the recovery and reduce the complications after the operation. 2020 Vol. 27 (7): 205-207 [Abstract] ( 64 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 208 Application effect of psychological nursing in patients with colorectal cancer ZHOU Wei-xiang; WANG Si-xuan; LUO Mu-lin; LI Huai-jin Objective To explore the effect of psychological nursing intervention on the therapeutic effect, immune function and quality of life of patients with colorectal cancer. Methods A total of 92 patients with colorectal cancer admitted to our hospital from December 2017 to December 2018 were selected and divided into study group and control group according to random number table method, 46 cases in each group. The control group received routine nursing,and study group combined with psychological nursing on the basis of control group. The differences of therapeutic effect, immune function and quality of life between the two groups were compared. Results The total effective rate was 80.43% in the study group, which was higher than 47.83% in the control group, the difference was statistically significant (P＜0.05). After treatment, the levels of immune function indexes in the study group were higher than those in the control group, the differences were statistically significant (P＜0.05）. After treatment, the scores of emotional status,physical status, functional status, family or social status in the study group were higher than those in the control group,the differences were statistically significant (P＜0.05). Conclusion Psychological nursing is an important part of postoperative nursing for patients with colorectal cancer. Effective psychological nursing can effectively improve the therapeutic effect, promote the improvement of clinical symptoms, help to improve their immune function and quality of life,and has a good clinical effect. 2020 Vol. 27 (7): 208-210 [Abstract] ( 70 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 211 Application effect of the new prone-positioning cushion in spinal surgery of obese patients YIN Peng-ying; WANG Li; HE Er-xing; DONG Qing-long Objective To investigate the application effect of new prone-positioning cushion in the spinal surgery of obese patients and its influence on the complications of respiratory and circulatory system. Methods Sixty obese patients who underwent spinal surgery in our hospital from January to October 2018 were enrolled in the study, they were divided into control group (n=30) and experimental group (n=30) according to random number table mtehod. The control group adopted conventional type of hollow square cushion, and the experimental group used a new prone-positioning cushion. The respiratory circulation index and skin compression of the two groups were compared. Results There were no significant differences in airway pressure, end-tidal carbon dioxide partial pressure, central venous pressure and arterial blood pressure between the two groups in the supine position for 10 min (P＞0.05). The airway pressure, the end-tidal carbon dioxide partial pressure, the central venous pressure and the arterial blood pressure in experimental group in 20, 40 min prone position were all lower than those in control group, the differences were statistically significant (P＜0.05). There was no significant difference in the incidence of vesicles between the two groups (P＞0.05). The incidence of pressure sores, skin damage, erythema and skin indentation in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion In the spinal surgery, obese patients using a new prone-positioning cushion can effectively control the risk of complications of the respiratory and circulatory system and reduce the incidence of skin compression. 2020 Vol. 27 (7): 211-213 [Abstract] ( 65 ) HTML (32 KB)  PDF  (0 KB)  ( 5 ) 214 Application effect of comprehensive nursing intervention in pregnant women with scarred uterus OU Feng-ying； CEN Shi-Qun； LIU Qiu-yun Objective To probe into the application effects of comprehensive nursing intervention in pregnant women with scarred uterus. Methods A total of 100 cases of pregnant women with scarred uterus who were treated in our hospital from January 2018 to January 2019 were retrospective analyzed, and the patients were divided into control group(n=50) and observation group (n=50) according to the nursing plan. The control group were treated with the routine nursing intervention, while the observation group were treated with the comprehensive nursing intervention. Then, the duration of labor, postpartum hemorrhage, hospitalization time, pain score and pregnancy outcome of two groups were compared and analyzed. Results The total course of labor and hospitalization time in the observation group were shorter than those in the control group, the amount of postpartum hemorrhage was less than that in the control group, the visual analogue scale （VAS） score and cesarean section rate were lower than those in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in Apgar score between the two groups (P＞0.05).The total nursing satisfaction in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The effect of comprehensive nursing intervention for pregnant women with scarred uterus are especially significant, which can effectively improve pregnancy outcomes, reduce labor time, reduce postpartum hemorrhage and pain, and ensure the safety of mothers and infants, thus it has clinical application value. 2020 Vol. 27 (7): 214-216转220 [Abstract] ( 63 ) HTML (34 KB)  PDF  (0 KB)  ( 12 ) 217 ffect of continuous nursing in the nursing of patients with chronic obstructive pulmonary disease MAI Cai-juan; HUANG Xue-mei; WANG Ya-nan; CEN Yun-hua; LIANG Chun-feng Objective To analyze the effect of continuous nursing in the nursing of patients with chronic obstructive pulmonary disease (COPD). Methods A total of 120 COPD patients treated in our hospital from January 2018 to February 2019 were selected and randomly divided into control group and observation group using the dichroic method,60 cases in each group. The control group was given the routine nursing intervention, while the observation group was given the continuous nursing intervention. The quality of life, self-management ability and pulmonary function before and after intervention were compared between the two groups. Results After intervention, the scores of physical health,mental health, physical role function, emotional role function, social function, physical pain, energy and overall health of the patients in the observation group were higher than those in the control group (P＜0.05). And the scores of selfmanagement ability scale items in the observation group after intervention were higher than those in the control group,the differences were statistically significant (P＜0.05). The one second forced expiratory volume (FEV1), FEV1/forced vital capacity (FVC) and arterial partial oxygen pressure in the observation group after intervention were higher than those in the control group, the differences were statistically siatistically significant (P＜0.05). The level of Paco in arterial blood in the observation group after intervention was lower than that in the control group and before intervation, the difference was statistically significant (P＜0.05). Conclusion Continuous nursing can significantly improve the quality of life and self-management ability of COPD patients, improve lung function, and has significant clinical application value. 2020 Vol. 27 (7): 217-220 [Abstract] ( 66 ) HTML (36 KB)  PDF  (0 KB)  ( 14 ) 221 Effect of joint mobilization training on early activity of severe pneumonia patients in ICU XU Zhen-hu1; MAO Xiu-lian2; LI Shi-peng3; ZENG Wei-bo1; CHEN Wen-ting1; XIE Jia-xin1 Objective To explore the effect of joint mobilization training on early activity of severe pneumonia patients in ICU. Methods A total of 72 patients with severe pneumonia in ICU were treated in our hospital from June 2017 to May 2018 were selected. The singular number of patients with severe pneumonia were treated as experimental group and double as control group, 36 cases in each group. The control group was given routine ICU nursing, while the experimental group was given additional joint mobilization training. The success rate of off-line, the satisfaction of nursing and the length of stay in ICU were compared between the two groups. Results The off-line success rate of the experimental group (91.67%) was higher than that of the control group (72.22%) (P＜0.05). The length of stay in ICU was(9.26±2.33) d, which was shorter than that of the control group of (12.35±2.86) d, and the difference was statistically significant (P＜0.05). The total satisfaction of nursing in the experimental group was higher than that in the control group. The difference was statistically significant (P＜0.05). Conclusion Joint mobilization training for ICU patients with severe pneumonia can not only effectively improve ventilator off line success rate but also shorten the hospital stay in ICU, and raise the satisfaction of nursing, which is worth clinical promoting. 2020 Vol. 27 (7): 221-223 [Abstract] ( 66 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 224 Application effect of bedside blind-inserted spiral nasal jejunal tube in nutritional support for patients with severe acute pancreatitis ZOU Mei-hua; LUO Wei-wen; ZHANG Yong-hui Objective To investigate the application effect of bedside blind-inserted spiral nasal jejunal tube in nutritional support for patients with severe acute pancreatitis (SAP). Methods A total of 64 patients with SAP admitted to our hospital from December 2016 to December 2018 were enrolled as subjects. All patients underwent enteral nutrition support with a spiral nasal jejunal tube. According to admission order, the patients were divided into the study group(n=32) and reference group (n=32). In the reference group, the patients were intubated aided with gastroscopy. In the study group, the patients were intubated by bedside blind insertion. The success rate of catheterization was compared between the two groups. The pain scores during catheterization and the occurrence of complications related to catheterization were observed. Results The difference in the success rate of catheterization between the two groups had no statistical significance (P＞0.05). The visual analogue scale (VAS) score of the study group was lower than that of the reference group, with statistical difference (P＜0.05). The incidence of complications including dyspnea, aspiration, nausea,vomiting and hemorrhage in the study group was lower than that in the reference group, the differences were statistically significant (P＜0.05). There was no statistical significance in the incidence of abdominal pain and the complication of upper gastrointestinal perforation (P＞0.05). Conclusion In the enteral nutrition support for patients with SAP, the bedside blind insertion of spiral nasal jejunal tube used for intubation is a simple and easy operation. It deserves promoting and applying in clinic because of its advantages including mild pain,few complications,low cost and demand for equipment. 2020 Vol. 27 (7): 224-226 [Abstract] ( 67 ) HTML (32 KB)  PDF  (0 KB)  ( 12 ) 227 Application effect of nursing plan for prevention of venous thromboembolism in patients with gynecologic malignancies YAN Su-qin; CHEN Ai-jun; SUN Qiu-hong Objective To explore the application effect of nursing plan sheet for prevention of venous thromboembolism（VET） in patients undergoing gynecological malignant tumor surgery. Methods A total of 78 cases with malignant tumors who underwent surgical treatment in our hospital from January 2017 to March 2018 were selected as the research objects. According to the random number table method,the patients were divided into control group(38 cases)and observation group (40 cases). Five nurses in the control group were given routine nursing to prevent VET, and five nurses in the observation group were given nursing plan sheet for prevention of VET. The knowledge of prevention of VET, the incidence of VETand the knowledge of prevention of VET were compared between the two groups. Results The cognitive score of prevention knowledge of VET in the observation group was higher than that in the control group (P＜0.05).The incidence of VET in the observation group was lower than that in the control group (P＜0.05). The cognitive score of nurses in the observation group was higher than that in the control group, the differences were statisticaly significant(P＜0.05). Conclusion The application of nursing plan sheet in patients with gynecological malignant tumors can improve their knowledge of prevention of VET, reduce the incidence of VET, optimize the nursing workflow and improve the professional level and service quality of nursing. 2020 Vol. 27 (7): 227-230 [Abstract] ( 66 ) HTML (37 KB)  PDF  (0 KB)  ( 10 ) 231 Application effect of removing stomach tube and comprehensive drainage and sputum nursing in elderly patients with sudden asphyxia ZHOU Shu-hong; HU Dan Objective To investigate the effect of removing gastric tube and comprehensive drainage on the treatment of sudden asphyxia in elderly patients. Methods From January 2017 to December 2018, 100 elderly patients with sudden asphyxia in our hospital were selected as objects of study. The patients were divided into observation group and control group by double-blind method, 50 cases in each group. The observation group took the removal of the gastric tube and cooperated with the comprehensive drainage and nursing, and the control group took the routine method of nursing. The effect was observed after 1 month of nursing, including total effective care, hospitalization time, body temperature recovery time, blood routine recovery time, 24 h average sputum volume, nursing satisfaction score, comfort score and quality of life score. Results The total effective rate of observation group was 98.00%, which was higher than that of the control group (74.00%); the difference was statistically significant (P＜0.05). The hospitalization time, body temperature recovery time and blood routine recovery time of the observation group were shorter than those of the control group, and the differences were statistically significant (P＜0.05). The average sputum volume at 24 h was lower than that of the control group, and the difference was statistically significant (P＜0.05). The nursing satisfaction score, comfort score and quality of life score of the observation group were higher than those of the control group (P＜0.05). Conclusion The treatment of elderly patients with sudden asphyxia in the removal of gastric tube and comprehensive drainage plan has significant effects, which can improve the patient′s satisfaction and shorten the hospitalization time. 2020 Vol. 27 (7): 231-233 [Abstract] ( 67 ) HTML (32 KB)  PDF  (0 KB)  ( 13 ) 234 Application effect of whole course high quality nursing in laser treatment of children with facial and neckhemangioma SHI Shan-shan; ZHANG Peng; GUAN Dong-xu; LIU Xiao-qian Objective To explore the application effect of whole-course high-quality nursing in laser treatment of children with facial and neck hemangioma. Methods A total of 72 children with congenital hemangioma who underwent laser treatment in our hospital were selected as the treatment objects from March 2018 to February 2019. The children were divided into control group and observation group according to random number table method, 36 cases in each group. The control group of childrens were used conventional nursing, the observation group take the whole quality nursing intervention. After the completion of nursing, the nursing effect was compared from the satisfaction score of the family members of the children on the nursing, the adverse reactions of the children in the nursing process and the rehabilitation effect after nursing. Results The business quality, psychological care and work efficiency satisfaction scores of the observation group were higher than those of the control group, with statistical differences (P＜0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The total effective rate of nursing in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The whole-course high-quality nursing mode can effectively improve the satisfaction of children′s family members on nursing work, reduce the incidence of postoperative adverse reactions, and improve the rehabilitation effect of children. 2020 Vol. 27 (7): 234-236 [Abstract] ( 70 ) HTML (32 KB)  PDF  (0 KB)  ( 16 ) 237 Application of continuous nursing in elderly patients with hypertension complicated with stroke ZHANG Yue Objective To explore application of continuous nursing in elderly patients with hypertension complicated with stroke. Methods A total of 80 patients with acute ischemic stroke (AIS) admitted to our hospital from November 2017 to January 2019 were selected as the research objects, and divided into observation group (40 cases) and control group (40 cases) according to different nursing methods. The control group received routine nursing while the observation group received continuous nursing after discharge based on the control group. The changes of protein index, drinking water and eating ability in the nutritional status of the two groups at 3 months after the intervention were compared,and the European stroke score (ESS) score and Barthel index of the two groups at 6 months after the intervention were counted. Results After 3 months of intervention, the levels of transferring, prealbumin and albumin in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).After 3 months of intervention, the recovery time of drinking water capacity and oral feeding capacity in the observation group was shorter than that in the control group, and the differences were statistically significant (P＜0.05). Following up for 6 months, the ESS score and Barthel index of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusions Continuous nursing for AIS patients can ensure the nutritional status of the body, reduce dysphagia, improve neurological function and improve the quality of life of patients. 2020 Vol. 27 (7): 237-239 [Abstract] ( 78 ) HTML (34 KB)  PDF  (0 KB)  ( 10 ) 240 Application of improved rapid rehabilitation surgery concept in perioperative period of thyroid surgery FANG Li-min; CHENG Li-ping Objective To explore application effect of modified fast-track surgery (FTS) concept on thyroid surgery during perioperative period. Methods A total of 90 patients undergoing thyroid surgery who were admitted to the hospital from May 2018 to July 2019 were enrolled. They were randomly divided into observation group and control group,30 cases in each group. The control group was given routine nursing measures. On the basis of control group, observation group was given nursing intervention of modified FTS concept. Perioperative indexes, psychological status and incidence of complications were compared between the two groups. Results The indwelling time of drainage tube， leaving bed time, eating time and the total hospitalization time in observation group were shorter than those of the control group, the differences were statistically significant (P＜0.05). After intervention, scores of self-rating anxiety scale (SAS)and self-rating depression scale (SDS) in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The incidence of postoperative complications in observation group was lower than that in control group (6.670% vs. 26.67%), the difference was statistically significant (P＜0.05). Conclusion The modified FTS concept can speed up postoperative rehabilitation process of patients undergoing thyroid surgery, improve their psychological status, and reduce incidence of postoperative complications. 2020 Vol. 27 (7): 240-242 [Abstract] ( 79 ) HTML (33 KB)  PDF  (0 KB)  ( 12 ) 243 Application effect of health education in patients with periodontitis ZHANG Hui Objective To discuss the application effect of periodontitis patients by health education. Methods A total of 562 cases periodontitis patients in our hospital from May 2018 to May 2019 were selected retrospective analysis.They were divided into control group 262 cases and detection group 300 cases by implementing health education or not. The oral health self-efficacy score, oral health life quality score, oral health behavior score of two group patients before and after intervention were compared. Results The regular dental visits, brush teeth properly, balanced diet score, oral physiological function, pain sensation, mental function and behavioral effects, oral health behavior score of two group patients before intervention the difference were no statistical significance (P＞0.05). After intervention, regular dental visits, brush teeth properly, balanced diet score, oral health behavior score of patients in the two group were higher than before intervention, oral physiological function, pain sensation, mental function and behavioral effect were lower than before intervention, regular dental visits, brush teeth properly, balanced diet score, oral health behavior score of detection group patients were higher than those of the control group, oral physiological function, pain sensation,mental function and behavioral effect were lower than those of the control group, the differences were statistical significance (P＜0.05). Conclusion The application of periodontitis patients by health education，which could increase oral health self-efficacy and oral health behavior, improve oral health life quality, it is worth to used. 2020 Vol. 27 (7): 243-245转249 [Abstract] ( 75 ) HTML (33 KB)  PDF  (0 KB)  ( 12 ) 246 Application effect of health education intervention based on knowledge,attitude, practice model in patients with schizophrenia in rehabilitation period ZOU Hai-yun； XIAO Hui-li ； ZHANG Ying-lian Objective To investigate the application effect of health education intervention based on knowledge, attitude, practice (KAP) model in patients with schizophrenia in rehabilitation period. Methods A total of 108 patients with schizophrenia who underwent rehabilitation nursing in our hospital from September 2018 to February 2019 were enrolled in the study. They were randomly divided into observation group and control group by envelope method, 54 cases in each group. The control group was given routine health education. On this basis, the observation group was given health education intervention based on KAP model. The rehabilitation status was compared between the two groups before and after intervention. Results The compliance rates of medication, physical training, nutritional diet, social activities, rehabilitation training and living habits of the observation group after intervention were higher than those of the control group (P＜0.05). The scores of psycho-social factor, dynamic energy symptoms, symptoms and side effects of both groups after intervention were lower than before intervention. Besides, the above scores of the observation group after intervention were lower than those of the control group (P＜0.05). After intervention, scores of positive and negative syndrome scale (PANSS) and social disability screening schedule (SDSS) of both groups were lower than those of before intervention, while scores of general self efficacy scale (GSES) were high than that of before intervention, SDSS and PANSS scores of the observation group after intervention were lower than those of the control group, while the GSES score was higher than the control group (P＜0.05). Conclusion The application of health education intervention based on KAP model is relatively better in patients with schizophrenia during rehabilitation period. It can significantly improve quality of life, clinical symptoms and compliance behavior of patients, further improve social function and self-efficacy,with good prognosis. It is worthy of clinical promotion and application. 2020 Vol. 27 (7): 246-249 [Abstract] ( 79 ) HTML (33 KB)  PDF  (0 KB)  ( 13 ) 250 Effect of individualized continuous nursing on children with allergic rhinitis LI Xuan Objective To approach the effect of individualized continuous nursing on children with allergic rhinitis(AR). Methods A total of 220 cases of AR children treated in our hospital from October 2017 to March 2018 were selected and divided into usual nursing group and personalized continuity nursing group according to difference nursing method, 110 cases in each group. The usual nursing group was given usual nursing, the personalized continuing nursing group was given personalized continuity nursing based on usual nursing. Sneeze reduction time, nasal secretion reduction time, nasal mucosa swelling time were compared between two groups, and the clinical efficacy and treatment compliance of two groups were compared. Results The sneeze reduction time ([4.0±1.0] d), nasal secretion reduction time([5.0±1.8] d) and nasal mucosal edema reduction time ([6.8±1.8] d), in personalized continuing nursing group were shorter than those in routine nursing group for (5.7±1.4), (7.5±2.0) and (8.9±2.0) d, the differences were statistically significant (P＜0.05). The total clinical effective rate of children with allergic rhinitis in individualized continuing nursing group was 100.0%, higher than that in routine nursing group (71.8%), the difference was statistically significant (P＜0.05). The clinical compliance of children with allergic rhinitis in individualized continuing nursing group was higher than that in routine nursing group, the difference was statistically significant (P＜0.05). Conclusion The clinical symptoms of AR children by personalized continuous nursing could improve, which could increase clinical effect and children′s adherence, which is worthy of promotion. 2020 Vol. 27 (7): 250-252 [Abstract] ( 73 ) HTML (32 KB)  PDF  (0 KB)  ( 9 )

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