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| Clinical significance of combined detection of serum amino terminal brain natriuretic peptide precursor and cardiac troponin I in patients with chronic heart failure |
| LIU Ban |
| The Third Department of Cardiology, Liaoning Provincial Health Industry Group Iron and Coal General Hospital, Tieling 112700, China |
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Abstract Objective To investigate the clinical significance of combined detection of serum aminoterminal brain natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI) in patients with chronic heart failure. Methods Fortynine patients with chronic heart failure admitted to our hospital from March to December 2018 were selected as the observation group, and 49 healthy patients in our hospital during the same period were selected as the control group for retrospective analysis. The New York Heart Association (NYHA) cardiac function classification method was used to further divide the observation group into：NYHA Ⅱobservation group(17 cases),NYHA Ⅲobservation group(16 cases),NYHA Ⅳobservation group (16 cases). Both the observation group and the control group received latex-enhanced immunoturbidimetry and antibody sandwich immunoassay. The concentrations of cTnI and NT-proBNP were compared between the two groups. The concentrations of cTnI and NT-proBNP were compared in the NYHA Ⅱ, Ⅲ, and Ⅳobservation groups. The true positive rate of cTnI, NT-proBNP concentration combined detection and single detection in the observation group was compared. Results The cTnI and NT-proBNP in the observation group were higher than those in the control group, the differences were statistically significant (P ＜0.05). The cTnI and NT-proBNP concentrations in the NYHA Ⅱobservation group were lower than those in the NYHA Ⅲand Ⅳobservation group, the differences were statistically significant (P＜0.05). The concentration of cTnI and NT-proBNP in NYHA Ⅳobservation group were higher than those in NYHA Ⅲobservation group, the differences were statistically significant (P＜0.05). The true positive rate of cTnI+NT-proBNP combined detection was higher than that of cTnI and NT-proBNP single detection, and the differences were statistically significant (P＜0.05). In the observation group, the true positive rate of cTnI single detection was lower than that of NT-proBNP single detection, and the difference was statistically significant(P＜0.05). Conclusion The combined detection of serum NT-proBNP and cTnI can effectively improve the detection rate of patients with chronic heart failure, which is worthy of popularization.
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