2型糖尿病患者血清胱抑素C、尿酸水平与骨密度的相关性分析

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Abstract Objective To explore the relationship between serum cystatin C, uric acid and bone mineral density in patients with type 2 diabetes mellitus, and to analyze the related factors of diabetic osteoporosis. Methods From January 2018 to May 2019, 228 patients with type 2 diabetes treated in the Department of Endocrinology, the Second Affiliated Hospital of Zhengzhou University were selected. According to the World Health Organization (WHO) diagnosis standard of osteoporosis, they were divided into normal bone mass group (43 cases), low bone mass group (87 cases), osteoporosis group(77 cases)and severe osteoporosis group(21 cases).The general data of patients were collected.The correlation between biochemical parameters and bone mineral density was analyzed and the possible mechanism was discussed. Results There were significant differences in sex, age, course of disease, diastolic pressure, glycosylated hemoglobin, total cholesterol,triacylglycerol,high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, blood phosphorus, alkaline phosphatase, blood creatinine, blood uric acid, serum cystatin C, 25 hydroxyvitamin D and estimated glomerular filtration rate, lumbar spine 1-4 (L1～4) bone mineral density, bilateral femoral neck bone mineral density among the four groups (P＜0.05). There were no significant differences in body mass index、systolic blood pressure、fasting plasma glucose、2-hour postprandial glucose C-peptide、serum Ca、blood urea nitrogen among the four groups (P＞0.05). Correlation analysis showed that bone mineral density of L1～4 positively correlated with serum uric acid,alkaline phosphatase (r=0.334, 0.443; P＜0.05), negatively correlated with serum P, glycosylated hemoglobin, cystatin C(r=-0.224, -0.371, -0.357; P＜0.05); bone mineral density of the left femoral neck positively correlated with serum uric acid, alkaline phosphatase (r=0.242, 0.607; P＜0.05), negatively correlated with serum P, glycosylated hemoglobin, cystatin C (r=-0.156, -0.351, -0.442; P＜0.05)；bone mineral density of the right femoral neck positively correlated with serum uric acid、alkaline phosphatase (r=0.229, r=0.609; P ＜0.05), negatively correlated with serum P, glycated hemoglobin, cystatin C (r=-0.134, -0.276, -0.414; P＜0.05). Multiple linear regression analysis showed that glycosylated hemoglobin, alkaline phosphatase, serum cystatin C and uric acid were the related factors affecting bone mineral density in patients with type 2 diabetes mellitus (P＜0.05). Conclusion High levels of serum cystatin C may be risk factors for osteoporosis in patients with type 2 diabetes, and high blood levels of uric acid may be the protection factors.

Key words： Cystatin C Serum uric acid Type 2 diabetes mellitus Bone mineral density

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	Articles by authors
	MU Yu-jing
	LI Jun
	LI Qing-ju
	FAN Meng-di

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MU Yu-jing,LI Jun,LI Qing-ju, et al. Correlation analysis of serum cystatin C, uric acid and bone mineral density in patients with type 2 diabetes mellitus[J]. 中国当代医药, 2020, 27(7): 4-8.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I7/4

[9]	王潇丽，徐丽丽，杨乃龙.尿酸对人骨髓间充质干细胞成骨分化过程中Wnt 信号通路的影响[J].中国组织工程研究，2015，19（28）：4472-4477.
[1]	Oei L，Rivadeneira F，Zillikens MC，et al.Diabetes，diabetic complications，and fracture risk[J].Curr Osteoporos Rep，2015，13（2）：106-115.
[2]	Shanbhogue VV，Mitchell DM，Rosen CJ，et al.Type 2 diabetes and the skeleton： new insights into sweet bones[J].Lancet Diabetes Endocrinol，2016，4（2）：159-173.
[3]	Adil C，Ayd1n T，Tasp1nar O，et al.Bone mineral density evaluation of patients with type 2 diabetes mellitus[J].Phys Ther Sci，2015，27（1）：179-182.
[5]	Maiuolo J，Oppedisano F，Gratteri S，et al.Regulation of uric acid metabolism and excretion[J].Int J Cardiol，2016，213：8-14.
[7]	Ezzat S，Louka ML，Zakaria ZM，et al.Autophagy in osteoporosis：relation to oxidative stress[J].J Cell Biochem，2018，9：2560-2568.
[8]	温滨红，张艳阳，赵璐，等.利拉鲁肽对糖尿病骨质疏松大鼠骨代谢、炎性反应和氧化应激的影响[J].中华骨质疏松和骨矿盐疾病杂志，2017，10（6）：550-556.
[4]	Raska IJ，Rasková M，Zikán V，et al.Body composition is associated with bone and glucose metabolism in postmenopausal women with type 2 diabetes mellitus[J].Physiol Res 2017，66（1）：99-111.
[6]	Sharma T，Islam N，Ahmad J，et al.Correlation between bone mineral density and oxidative stress in postmenopausal women[J].Indian J Endocr Metab，2015，19（4）：491-497.
[10]	Chen L，Peng Y，Fang F，et al.Correlation of serum uric acid with bone mineral density and fragility fracture in patients with primary osteoporosis：a single-center retrospective study of 253 cases[J].Int J Clin Exp Med，2015，8（4）：6291-6294.
[11]	Neer RM，Arnaud CD，Zanchetta JR，et al.Effect of parathyroid hormone （1-34） on fractures and bone mineral density in postmenopausal women with osteoporosis[J].New Engl J Med，2001，344（19）：1434-1441.
[12]	Makovey J，Macara M，Jian SC，et al.Serum uric acid plays a protective role for bone loss in pefi-and postmenopausal women：a longitudinal study[J].Bone，2013，52（1）：400-406．
[13]	Ketteler M，Block GA，Evenepoel P，et al.Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder （CKD-MBD） Guideline Update： what′s changed and why it matters [J].Kidney Int，2017，92（6）：26-36.
[14]	Rigalleau V，Lasseur C，Raffaitin C，et al.Bone loss in diabetic patients with chronic kidney disease[J].Diabet Med，2007，24（1）：91-93.
[15]	马远征，王以朋，刘强，等.中国老年骨质疏松症诊疗指南（2018）[J].中国骨质疏松杂志，2018，24（12）：1541-1567.