高负荷剂量替考拉宁治疗耐甲氧西林金黄色葡萄球菌感染肺炎的临床效果

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Abstract Objective To analyze the clinical effect of high-load dose of Teicoplanin in the treatment of Methicillin resistant Staphylococcus aureus (MRSA) pneumonia. Methods A total of 252 patients with pneumonia infected with MRSA in Yangjiang People′s Hospital from January 2017 to December 2018 were selected as research subjects, they were divided into a high-load dose group (n=126) and a low loading dose group (n=126) according to the random number table method. Patients in the high-load dose group received high-load Teicoplanin treatment, patients in the low-load dose group received low-load Teicoplanin treatment. The pulmonary inflammatory exudation lesion absorption, clinical treatment effect, bacterial clearance, body temperature (T) and inflammatory indexes before and after treatment were compared between the two groups. Results The absorption of pulmonary inflammatory exudation lesions in the highload dose group was better than that in the low-load dose group, the difference was statistically significant (P＜0.05).The total effective rate of treatment in the high-load dose group was 95.2%, which was higher than 79.4% in the lowload dose group, the difference was statistically significant (P＜0.05). The total bacterial clearance rate of the high-load dose group was 89.7%, which was higher than 64.3% of the low-load dose group, the difference was statistically significant (P＜0.05). The C-reactive protein (CRP) and white blood cell count (WBC) of the high-load dose group were lower than those of the low-load dose group, the differences were statistically significant (P＜0.05). Conclusion Treatment of MRSA-infected pneumonia with high-load dose Teicoplanin can improve the absorption, treatment effect, and bacterial clearance of inflammatory exudation lesions in the lungs, and reduce the inflammatory index of patients.

Key words： High-load dose Teicoplanin;Methicillin resistant Staphylococcus aureus infection;Pneumonia;Imaging Bacterial clearance rate Inflammatory indicators

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	Articles by authors
	ZHANG Zhi-hui
	FENG Yu-shan
	LI Kong-zheng3

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ZHANG Zhi-hui,FENG Yu-shan,LI Kong-zheng3. Clinical effect of high-load dose of Teicoplanin in the treatment of Methicillin resistant Staphylococcus aureus pneumonia[J]. 中国当代医药, 2020, 27(7): 178-180转184.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I7/178

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