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| Effect of Metoprolol combined with Trimetazidine on inflammatory factors and cardiac function in patients with coronary heart disease and heart failure |
| TANG Zeng-yao LIU Ji-wen WANG Xin-wang ZHU Bao-cheng LIU Yu-lian |
| Department of Internal Medicine Cardiology, Jiujiang First People′s Hospital of Jiangxi Province, Jiujiang 332000,China |
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Abstract Objective To investigate the effect of Metoprolol combined with Trimetazidine on inflammatory factors and cardiac function in patients with coronary heart disease and heart failure. Methods A total of 104 patients with coronary heart disease and heart failure who were admitted to the Department of Cardiology, Jiujiang First People′s Hospital from July 2016 to June 2018 were selected as the research objects, they were divided into control group (52 cases)and observation group (52 cases) according to the random number table method. The control group was treated with Metoprolol, and the observation group was treated with Metoprolol combined with Trimetazidine. The clinical treatment effect, inflammatory factor levels and cardiac function indexes before and after treatment, and total incidence of adverse reactions were compared between the two groups. Results The total effective rate in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). The levels of tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hs-CRP) in the two groups after treatment were lower than those before treatment, the levels of TNF-α, IL-6 and hs-CRP in the observation group after treatment were lower than those in the control group, the differences were statistically significant (P＜0.05). After treatment, the left ventricular ejection fraction (LVEF) in the two groups was higher than that before treatment, the left ventricular endsystolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) were lower than those before treatment,the LVEF after treatment in the observation group was higher than that in the control group, and LVESD and LVEDD were lower than those in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the overall incidence of adverse reactions between the two groups (P＞0.05). Conclusion The treatment of patients with coronary heart disease and heart failure with Metoprolol combined with Trimetazidine can effectively improve the treatment effect, improve cardiac function, and reduce the level of inflammatory factors, which is worthy of clinical application.
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