乌司他丁联合生长抑素治疗急性胰腺炎的效果

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Abstract Objective To explore the effect of Ulinastatin combined with Somatostatin in the treatment of acute pancreatitis in emergency. Methods Sixty patients with acute pancreatitis admitted to our hospital from January 2017 to January 2019 were enrolled in the study. According to the random number table method, they were divided into drug alone treatment group and combined drug treatment group, 30 cases in each group. The drug alone group was treated with Somatostatin, and the combined group was treated with Somatostatin+Ulinastatin. The therapeutic effects on pancreatitis including the time of blood amylase to return to normal range, the time of urinary amylase to return to normal range,hospital stay, acute and chronic health scores (APACHE Ⅱ), urine amylase monitoring level before and after treatment,blood amylase monitoring level, interleukin-6, tumor necrosis factor-α, and adverse reactions in the two groups were compared. Results The total effectiveness rate of the combined drug group was higher than that of the drug alone group, and the difference was statistically significant (P＜0.05). The time when the blood amylase returned to the normal range, the time when the urinary amylase returned to the normal range and the hospital stay in the combined drug group were shorter than those in the drug alone group, the difference were statistical singificant (P＜0.05). The APACHEⅡscore, urine amylase monitoring, blood amylase monitoring, interleukin-6 and tumor necrosis factor-α in the combined drug group were lower than those in the drug alone group, the difference were statistical singificant (P＜0.05).There was no statistical difference in the overall incidence of adverse reactions between the two groups (P＞0.05). Conclusion Application of Somatostatin+Ulinastatin is effective in the treatment of pancreatitis, which can improve blood urea gelatinase, control inflammation, facilitate recovery and shorten treatment time.

Key words： Emergency Ulinastatin Somatostatin Pancreatitis Effect

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	Articles by authors
	LAI Run-kang
	LU Zhun-biao

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LAI Run-kang,LU Zhun-biao. Effect of Ulinastatin combined with Somatostatin in the treatment of acute pancreatitis[J]. 中国当代医药, 2020, 27(7): 36-38.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I7/36

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