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2017 Vol. 24, No. 32 Published: 2017-11-18

	4	Influence of NRG1 transfection on expression of VEGF in bone marrow stromal stem cells
		WANG Kai;YAN Lei;LIU Zhi-xin; LIANG Jun
		ObjectiveTo explore whether bone marrow stromal stem cells(BMSCs)could been promoted by NRG1 transfection to VEGF expression.MethodsThe BMSCs of three SD rats were isolated and cultured,BMSCs were transfected with NRG1 plasmids,and the supernates were extracted.The contents of VEGF in the supernates were detected by the method of ELISA,and the samples of BMSCs were regarded as the control group.The expression of VEGF in BMSCs was detected by immunohistochemical method.ResultsMost of BMSCs were stretched and spindle-shaped.The levels of VEGF in the transfection group were increased with time by ELISA detection,compared with the control group,there was significant difference(P＜0.05).The VEGF positve cell rate of the transfection group was 91.07%by immunohistochemical detection,while the positive cell rate of the control group was 70.82%,there was significant difference compared with the control group(P＜0.05).ConclusionBMSCs can promoted by NRG1 transfection to express VEGF.
		2017 Vol. 24 (32): 4-7 [Abstract] ( 185 ) HTML (38 KB) PDF (0 KB) ( 67 )

	8	Meta-analysis of the effect of cluster nursing on multiple drug-resistant bacteria
		YANG Xiao-ling;JIANG Hu;LENG Zhi-bing;PU Heng-ping
		ObjectiveTo systematic evaluate the clinical effect of cluster nursing on prevention and control of multiple drug-resistant bacterial infections.MethodsThe databases of Pubmed,EMBase,Cochrane Library,CNKI,CBM,Wanfang,and VIP were searched by computer,so as to retrieve randomized controlled or non-randomized controlled trialson the cluster nursing for prevention and control of multiple drug-resistant bacterial infections.The search deadline was from the database establishment time until December in 2016.Based on the inclusion and exclusion criteria,independent screening of literature and extract of data were carried out by two reviewers,and RevMan 5.2 software package was used for statistical analysis.ResultsA total of 14 articles and 20 693 patients were included.Meta analysis showed that cluster nursing intervention could reduce the incidence rate of MDRO during hospitalization[OR=0.56,95%CI(0.51,0.61),P＜0.00001],improve the cure rate after MDRO infection [OR=2.51,95%CI(1.45,4.32),P=0.0009],reduce the mortality after MDRO infection[OR=0.40,95%CI(0.23,0.69),P=0.0009],prolonged the hospital stay before MDRO infection[SMD=4.49,95%CI(2.20,6.79),P=0.0001],shorten the hospital stay after MDRO infection[SMD=-32.15,95%CI(-57.51,-6.78),P=0.01],reduce the overall hospital stay[SMD=-3.31,95%CI(-4.53,-2.10),P＜0.00001],and reduce the average daily cost for the treatment of MDRO infection[SMD=-8.81,95%CI(-12.83,-4.80),P＜0.0001]).ConclusionBased on the available evidence in this paper,cluster nursing is a viable and effective intervention for MDRO.However,because of the low quality of the literature included,the above conclusions should be further verified bymore large sample and high quality clinical randomized trials.
		2017 Vol. 24 (32): 8-12 [Abstract] ( 207 ) HTML (52 KB) PDF (0 KB) ( 72 )

	13	Research and prospect of eight famous herbal drugs in Zhejiang and related health food
		SUN Jian-feng;WANG Shu-ling;LI Hua;LIU Xu-wen;ZHOU Xiao-xiao;HU Jin-dong ;SHENG Xiao-dan;XIE Tian
		Eight famous herbal drugs in Zhejiang means Baizhu,Baishao,Zhebeimu,Hangbaiju,Yanhusuo,Xuanshen,Jianmaidong and Wenyujin.They are Zhejiang authentic herbs.They are not only used in treatment,but also more valued in health care industry.Combining with relevant documents of CFDA and literature,summarize the expound pharmacological study related to Eight famous herbal drugs in Zhejiang traditional Chinese medicine and related function food.And provide a outlook of its further development and utilization.
		2017 Vol. 24 (32): 13-16 [Abstract] ( 186 ) HTML (44 KB) PDF (0 KB) ( 44 )

	17	Clinical study on respiratory rate，compliance，oxygenation and breathing force index in predicting offline capability in ICU patients
		ZHAN Gen-sheng;ZHANG Man-liang;LI Li-rong;ZHANG Qian-wei
		ObjectiveTo evaluate the clinical value of breathing force index and fast and shallow breathing index in predicting offline capacity and weaning conditions in the ICU patients receiving mechanical ventilation.MethodsA total of 57 patients with chronic obstructive pulmonary disease(COPD)who were admitted to ICU in our hospital and given mechanical ventilation and successful weaning from March 2015 to March 2017 were selected.Then 57 patients with COPD who were given mechanical ventilation during the same period but the weaning was failed were selected.The patients were respectively assigned to the study group and the control group.The existing ventilator in our hospital was adopted to measure the two indices of breathing force index and fast and shallow breathing index in the study subjects of both groups,and the measurement results of the two indices and the positive rate of results were compared.ResultsThe breathing force index in the study group was significantly higher than that in the control group,and the difference between groups was significant(P＜0.05);the fast and shallow breathing index was lower than that in the control group,and the difference was significant(P＜0.05).The positive rate of breathing force index and fast and shallow breathing index positive rate of the difference was significant between the groups(P＜0.05).ConclusionIn the ICU patients receiving mechanical ventilation,the breathing force index for the patients with successful weaning is significantly higher than that in the failed ones,and the fast and shallow of breathing index is significantly lower than that in the failed ones.Clinically,according to this feature,a more objective and accurate judgment of whether the patient is in compliance with the conditions of weaning during the treatment can be made.
		2017 Vol. 24 (32): 17-19 [Abstract] ( 209 ) HTML (32 KB) PDF (0 KB) ( 65 )

	20	Effect of BiPAP ventilator combined with drug in the treatment of acute exacerbation of chronic obstructive pulmonary disease
		XIONG Yong;LIU Guo-sheng;LAI Peng
		ObjectiveTo investigate the effect of BiPAP ventilator combined with drug on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and its influence on E-selectin and D-dimer.MethodsFrom September 2013 to February 2017,82 COPD patients in acute exacerbation visited our hospital were enrolled and randomly divided into two groups.In control group(n＝40),conventional medicine was used,while in the observation group (n＝42),noninvasive BiPAP ventilator was added.A course of treatment was lasted for 7 days.The difference of clinical efficacy between the two groups was compared.ResultsAfter treatment,the FEV1/FVC and blood oxygen partial pressure were both increased，while the level of PaCO2,D-dimer,and E-selectin were decreased.The changes in the observation group were more remarkable,the difference was statistically significant(P＜0.05).The total effectiveness rate in the control group was 75.00%(30/40),and 95.24%(40/42)in the observation group,which was higher in the latter,the difference was statistically significant(P＜0.05).ConclusionCombination of BiPAP and medicine in the treatment of AECOPD obtain a remarkable effect,and can improve the blood gas index and inflammatory reaction,which is worthy of promotion.
		2017 Vol. 24 (32): 20-22 [Abstract] ( 195 ) HTML (34 KB) PDF (0 KB) ( 61 )

	23	Efficacy of Recombinant Human Thrombopoietin combined with Hormone in the treatment of thrombocytopenic purpura
		LI Xu-dan
		ObjectiveTo investigate the clinical efficacy of Recombinant Human Thrombopoietin combined with Hormone in the treatment of thrombocytopenic purpura （ITP）.Methods60 patients with ITP who treated in our hospital from March 2015 to June 2017 were selected as subject,they were randomly divided into observation group and control group,with 30 cases in each group.The control group was treated with Glucocorticoid therapy,and the observation group was used Recombinant Human Thrombopoietin treatment based on the control group,and platelet count,platelet recovery time were compared between the two groups before and after treatment.ResultsThe total efficiency of the observation group was 83.3%(25/30),significantly higher than the control group 66.7%(20/30),the difference was statistically significant(P＜0.05);patients in the observation group after treatment improved the platelet count was significantly higher than the control group,and platelet rise time significantly lower than the control group,the difference was statistically significant(P＜0.05).ConclusionRecombinant Human Thrombopoietin combined with Hormone therapy is effective in the treatment of ITP,which can promote the production of platelets rapidly and deserve clinical application and promotion.
		2017 Vol. 24 (32): 23-25 [Abstract] ( 160 ) HTML (32 KB) PDF (0 KB) ( 86 )

	26	Effect of Fexofenadine Hydrochloride combined with BCG polysaccharide nucleic acid on chronic urticaria
		LIN Ling
		ObjectiveTo study the effect of Fexofenadine Hydrochloride combined with BCG polysaccharide nucleic acid on chronic urticaria.Methods92 patients with chronic urticaria treated in our hospital from January 2016 to March 2017 were selected as subject.They were divided into two groups according to the treatment methods,with 46 cases in each group.The control group was treated with Fexofenadine Hydrochloride;treatment group was treated with Fexofenadine Hydrochloride combined with BCG polysaccharide nucleic acid treatment.The total effective rate,the symptom score before and after the concentration of histamine,the number of interleukin-10 and the number of wind masses were compared between the two groups.ResultsThe total effective rate of treatment group was significantly higher than that of the control group(P＜0.05).The control group the total effective rate was 76.09%;the total effective rate was 97.83%in the treatment group.There were no significant differences in the symptom scores,plasma histamine concentration,interleukin-10 and the number of wind masses before treatment(P＞0.05).The number of symptoms，plasma histamine concentration，interleukin-10 and wind group in the treatment group were significantly lower than those in the control group(P＜0.05).The time of disappearance of wind masses and pruritus was(12.51±1.01)d and(13.24±2.21)days in the treatment group,which was significantly shorter than that in the control group(16.01±2.73)d,(17.19±3.51)d,(P＜0.05).ConclusionThe effect of Fexofenadine Hydrochloride combined with BCG polysaccharide nucleic acid on the treatment of chronic urticaria is effective,which can shorten the course of treatment,accelerate the symptoms subsided and reduce the level of inflammation.
		2017 Vol. 24 (32): 26-28 [Abstract] ( 197 ) HTML (30 KB) PDF (0 KB) ( 81 )

	29	Clinical study on the invasive and non-invasive mechanical sequential ventilation in improving ventilatory function in the patients with respiratory failure
		ZHONG Ying-yu
		ObjectiveTo investigate the clinical study on invasive and noninvasive mechanical sequential ventilation in improving ventilatory function in patients with respiratory failure.Methods125 patients with respiratory failure who were admitted to our hospital from January 2014 to December 2016 were selected.According to the ventilation method,the patients were divided into the observation group(65 cases)and the control group(60 cases).The observation group was given invasive and noninvasive mechanical sequential ventilation,and the control group was only given invasive mechanical ventilation.Changes of PaO2,PaCO2,HR and RR were compared between the two groups before weaning,and the changes of PaO2,PaCO2,HR and RR levels upon extubation and BiPAP 4 h were observed in the observation group.The changes of invasive mechanical ventilation time,total mechanical ventilation time,weaning success rate and length of admission to ICU were observed in both groups.ResultsPaO2,PaCO2,HR and RR were compared between the two groups before weaning,and the difference was not statistically significant(P＞0.05);there was no statistically significant difference in PaO2,PaCO2HR,RR between upon extubation and at BiPAP 4 h in the observation group(P＞0.05);the invasive mechanical ventilation time and total mechanical ventilation time in the observation group were shorter than those in the control group(P＜0.05);the success rate of weaning in the observation group was higher than that in the control group.The length of stay in ICU was shorter than that in the control group,and the difference was statistically significant(P＜0.05).ConclusionThe invasive and noninvasive mechanical sequential ventilation has a significant effect of improving respiratory failure and can significantly shorten the time of invasive mechanical ventilation and the total time of mechanical ventilation，and improve the ventilation function of patients,which has an important significance of research.
		2017 Vol. 24 (32): 29-31 [Abstract] ( 189 ) HTML (36 KB) PDF (0 KB) ( 66 )

	32	Effect of different nutritional support program on respiratory muscle fatigue in respiratory intensive care unit
		ZHANG Shi-hao
		ObjectiveTo compare and analyze the different application effects of two nutrition support schemes in respiratory intensive care patients with respiratory muscle fatigue.Methods60 cases of respiratory muscle fatigue were selected from May 2016 to May 2017 in our hospital.Adopting digital random method,were divided into observation group(n＝30)and control group(n＝30),the observation group patients give enteral parenteral nutrition support,control group patients give enteral nutrition support,only watch two groups of patients before and after nutritional support of nutrition indicators,(former protein albumin,hemoglobin,upper arm circumference(TSF)and arm muscle circumference(AC),triceps skinfold(MCAM)),immune function index and pulmonary function index.ResultsThe thickness of albumin,preprotein,hemoglobin,upper arm circumference,upper arm circumference,and triceps of the triceps were significantly better than the control group,the difference was statistically significant(P＜0.05).In the observation group,FEV1%,FEV1/FVC,MIP,PaCO2,PaO2,and auxiliary respiratory muscle score were significantly better than the control group,the difference was statistically significant(P＜0.05).ConclusionEnteral parenteral nutrition support can effectively improve the respiratory intensive care unit well fatigue nutritional status of patients,improve immune function,in order to improve the well ability of patients,improve pulmonary function,clinical use value.
		2017 Vol. 24 (32): 32-34 [Abstract] ( 196 ) HTML (31 KB) PDF (0 KB) ( 69 )

	35	Correlation between ambulatory arterial stiffness index and carotid artery atherosclerosis in patients with type 2 diabetes mellitus and hypertension
		LIU Sang-yan;YANG Yang;TU Zhen-xing;LI Ye;WANG Yan
		ObjectiveTo investigate the changes of ambulatory arterial stiffness index (AASI)in the type 2 diabetes mellitus and hypertension,and to analysis the correlation between ambulatory arterial stiffness index and carotid artery atherosclerosis.MethodsThere were 180 patients with type 2 diabetes mellitus and hypertension who were treated in the department of endocrinology in our hospital from January 2015 to January 2017 were selected as subjects for the study.They were divided into there groups(the normal carotid intima-media group,the thickened carotid intima-media group and the plaque formation group)according to carotid intima-media (IMT)thickness.All the patients were tested for biochemical indicators,glycosylated hemoglobin,fasting insulin,carotid artery color ultrasound and 24 hours dynamic blood pressure.The AASI changes of patients in three groups were compared,AASI and the correlation of carotid atherosclerosis were investigated.ResultThe levels of SBP,DBP,TG,LDL-C,FPG,HbA1c,FINS,HOMA-IR,UA and Cystatin C in the thickened carotid intima-media group and the plaque formation group were significantly higher than those in the normal carotid intima-media group,and the differences were statistically significant(P＜0.01).The levels of SBP,DBP,TG,LDL-C,FPG,HbA1c,FINS,HOMA-IR,UA and Cystatin C in the plaque formation group were signifi-cantly higher than those in the thickened carotid intima-media group,and the differences were statistically significant(P＜0.01).The levels of AASI,IMT and RI in the thickened carotid intima-media group and the plaque formation group were significantly higher than those in the normal carotid intima-media group,while the levels of SV and DV were significantly lower than those in the normal carotid intima-media group,and the differences were statistically significant(P＜0.01).The levels of AASI,IMT and RI in the plaque formation group were significantly higher than those in the thickened carotid intima-media group,while the levels of SV and DV were significantly lower than those in the thickened carotid intima-media group,and the differences were statistically significant(P＜0.01).Single factor correlation analysis results showed that the levels of IMT were positive correlated with TG,LDL-C,SBP,DBP,PP,FPG,UA,Cystatin C,AASI,RI and age(r＝0.482,0571,0.667,0.509,0.603,0.711,0.386,0.504,0.727,0.623,0.472;P＜0.05),while the levels of IMT were negatively correlated with SV,DV(r＝-0.567,-0.611;P＜0.01).Multiple stepwise regression analysis revealed that the levels of IMT were independent of PP,AASI,FPG,UA,LDL-C(β＝1.229,1.442,0.887,1.501,1.884;P＜0.05).Conclusions With the IMT increased,the levels of AASI are significantly increased and it is closely correlated with carotid artery intimamedia thickness,which reveale the AASI may be a predictive factor of the carotid atherosclerosis.
		2017 Vol. 24 (32): 35-38转42 [Abstract] ( 171 ) HTML (41 KB) PDF (0 KB) ( 76 )

	39	Clinical study of resection of benign thyroid tumor under endoscope and traditional open surgery for benign thyroid tumor
		LI Lin-yuan;MAI Jian-quan;YE Shao-guang
		ObjectiveTo investigate the clinical effect of resection of benign thyroid tumor under endoscope and traditional open surgery for benign thyroid tumor.Methods108 patients with benign thyroid tumors treated in department of general surgery of our hospital from January 2012 to June 2017 were selected as subjects.According to different surgical methods,they were divided into control group (treated with traditional open surgery,n＝50)and observation group(treated with resection of benign thyroid tumor,n＝58).The operation time,bleeding volume,postoperative drainage time,postoperative drainage volume,hospital stay,pain score of 7 days after surgery,cosmetic effect score of 7 days after surgery and postoperative complications were observed and compared between the two groups.ResultsThe operation time,postoperative drainage time and hospital stay were [(70.2±8.9)min,(41.5±9.6)ml,(1.5±0.3)d,(71.9±10.6)ml,(5.2±0.5)d],which were all lower than that in the control group [(94.7±10.4)min,(73.7±10.2)ml,(2.7±0.8)d,(104.5±10.2)ml and(8.0±1.5)d],and the differences were statistically significant(P＜0.05).In the observation group,the pain score of 7 days after surgery was[(2.5±0.3)points],which was lower than that in the control group[(3.8±0.6)points],and the difference was statistically significant(P＜0.05).The cosmetic effect score of 7 days after surgery was[(8.4±1.5)points],which was greatly higher than that in the control group[(4.4±1.2)points],and the differences were statistically significant(P＜0.05).The incidence of subcutaneous emphysema,hoarseness,swelling at the open of drainage,numbness around the mouth or hand and foot and bucking on drinking water were compared between the two groups,and the differences were not statistically significant(P＞0.05).ConclusionFor patients with thyroid disorders,resection of benign thyroid tumors under endoscope has advantages of mild surgical trauma and great cosmetic effect,which is worthy of clinical promotion.
		2017 Vol. 24 (32): 39-42 [Abstract] ( 192 ) HTML (36 KB) PDF (0 KB) ( 58 )

	43	Analysis of the difference between the first and second drop blood in blood glucose of critically ill patients
		CHENG Lin-zhi;DING Li-na ;WU Xiao-ying
		ObjectiveTo analyze the difference between using the first and the second drop of blood in blood glucose monitoring of critically ill patients,and to provide clinical practice for information.MethodsThe 30 patients who were admitted to ICU in yongchuan hospital affiliated with chongqing medical university from September to November 2016 were selected randomly as subjects.Patients′middle or ring fingers were sterilized with 75%alcohol after their ipsilateral arms were hang for a moment,and tested for the blood glucose values through the first and second drop of blood.A total of 52 valid data sets were collected.The data of the two groups of patients with the first and second drop of blood were compared and statistically analyzed.ResultsThere was no significant difference in the blood glucose values between the first and the second drop of blood among critically ill patients (P＞0.05).ConclusionIn the precondition of normative operation,using the first drop of blood to monitor blood glucose is as accurate as using the second drop of blood,so it is recommended to use the first drop of blood.And it can simplify the blood sugar monitoring process,shorten care operation time,reduce iatrogenic pollution,save medical consumables and reduce patients′pain,so it is worth of promoting the application in clinic.
		2017 Vol. 24 (32): 43-45 [Abstract] ( 191 ) HTML (31 KB) PDF (0 KB) ( 34 )

	46	Clinical effect of Metformin in the treatment of polycystic ovary syndrome
		LIU Yu-ting ;LIU Dong-fang;YANG Gang-yi;LI Ling-ou
		ObjectiveTo inbestigate the clinical effect of Metformin in the treatment of polycystic ovary syndrome(PCOS).MethodsFrom January 2012 to August 2013,58 PCOS patients treated in our hospital were selecteded into PCOS group and 85 healthy women were into control group.The PCOS patients were treated with 850 mg Metformin,twice daily for 24 weeks,53 patients completed the treatment finally.The levels of serum insulin and LH,FSH,T,E2,PRL,PROG,DHEA-S,SHBG were compared between the PCOS group and control group.The changes of indexes mentioned above before and after therapy were compared in PCOS group.The improvement of the menstrual cycle during the treatment and the pregnancy rate after medication by follow-up visits were monitored.ResultsIn the PCOS group,the body weight,BMI,FIns,2 h Ins,HOMA-IR,LH,LH/FSH,and T were higher than those in the control group,and the SHBG level was lower than that in the control group,and the differences were statistically significant(P＜0.05).The other indicators of the two groups were compared,and the differences were not statistically significant(P＞0.05).The indexes including BMI,LH,LH/FSH,T,FIns,2 h Ins and HOMA-IR were lower than those before treatment,and SHBG was higher than before treatment,the differences were statistically significant(P＜0.05).The FSH,DHEA-S,E2,PRL and PROG before and after treatment were compared,and the differences were not statistically significant(P＞0.05).In PCOS group,11 patients(20.75%)had regular menstrual cycle before treatment,after 3 months of therapy,the proportion of menstrual regularity was 69.81%,and the proportion of menstrual regularity was 75.47%after the 6 months of treatment,which were all higher than before treatment,the differences were statistically significant(P＜0.05).Besides,the pregnancy rate was 46.67%in the sixth months after treatment.ConclusionThe levels of sex hormones,menstrual and reproductive status in PCOS patients were significantly varied from those of normal women.Metformin could effectively improve the sex hormone level,adjust the menstrual cycle disorder,and improve the pregnancy rate.It is a good choice for the treatment of PCOS.
		2017 Vol. 24 (32): 46-49 [Abstract] ( 178 ) HTML (40 KB) PDF (0 KB) ( 66 )

	50	The application of Glisson pedicle transection hepatic resection in preventing recurrence of tumor
		LI Yuan;WEN Zeng-qing;YAO Jun;GU Lin-ming;ZHOU Ning-jie;YANG En-min
		ObjectiveTo investigate the application effect of Glisson pedicle transection hepatic resection at the porta hepatisin for preventing recurrence of tumor.Methods60 patients given hepatic resection in our hospital from May 2015 to July 2016 were selected as objects.Patients were divided into the control group and study group according to the treatment method.30 cases in the control group were given general hepatic resection,while 30 patients in the study group were given Glisson pedicle transection hepatic resection.The effect of two surgical methods on preventing recurrence of liver tumor was compared.ResultsThere operation time had no statistical difference between the two groups (P＞0.05).The difference of intraoperative bleeding amount,length of stay,the incidence of complication,ALT and Alb after the first and seventh day operation were significant(P＜0.05).Followed-up 1 year,the recurrence rate of the study group was 10.0%,which was lower than that of the control group (36.7%),and there was a statistical difference between the two groups (P＜0.05).ConclusionGlisson pedicle transection hepatic resection can reduce the intraoperative bleeding amount and reduce the recurrence of liver tumor.The effect is obvious,and the survival rate of the patients is improved,which has an application value.
		2017 Vol. 24 (32): 50-52 [Abstract] ( 198 ) HTML (31 KB) PDF (0 KB) ( 86 )

	53	Effect of Qijiao Shengbai Capsules on leukopenia in lung cancer patients after radiotherapy and its influence on quality of life
		CHEN Bo;WU Wen-jie
		ObjectiveTo explore the clinical effect of Qijiao Shengbai Capsules on leukopenia in lung cancer patients after radiotherapy,and improvement of the quality of life in these patients after medication.MethodsFrom July 2014 to March 2017,102 patients with lung cancer admitted into our hospital were enrolled.All patients were performed with radiotherapy.Using the random grouping method,they were divided into the research group(n＝51)and control group(n＝51).The patients in the control group were provided with routine nutritional support,symptomatic treatment,and thoracic and abdominal drainage.In the research group,oral administration of Qijiao Shengbai Capsules on the first day after radiotherapy was added besides the same treatment in the control group.During hospitalization,blood test once per week was necessary.The incidence of myelosuppression and changes of white blood cell count before and after radiotherapy were compared between the two groups.ResultsIn the research group,the incidence of myelosuppression was 17.64%,which was much lower than that in the control group(68.63%),and the white blood cell count in the research group was greatly increased compared with that in the control group,which was displayed a statistical difference(P＜0.05).ConclusionFor lung cancer patients performed with radiotherapy,application of Qijiao Shengbai Capsules can obtain a favorable control effect on leukopenia and decrease the incidence of myelosuppression,which is of great importance on promoting rehabilitation of patients.
		2017 Vol. 24 (32): 53-55 [Abstract] ( 186 ) HTML (32 KB) PDF (0 KB) ( 73 )

	56	Prospective study of ERCC1,BRCA1,and RRM1 expression on the individualized treatment of advanced non-small cell lung cancer
		DING Jian-wu;TANG Luo-yong;AI Su-fen;ZHANG Feng-hao;HUANG Long;HU Rong-huan;XIONG Qiang
		ObjectiveTo investigate the application value of excision repair cross-complementing gene 1(ERCC1),breast cancer susceptibility gene 1 (BRCA1),and ribonucleotide reductase M1 subunit(RRM1)expression in the individualized treatment of advanced non-small cell lung cancer(NSCLC).MethodsFrom June 2015 to August 2016,50 patients with advanced NSCLC visited our hospital were recruited as research subjects.Using an odd/even number grouping model,they were grouped and there were 25 cases in each group.In the experimental group,the level of ERCC1,BRCA1,and RRM1 were tested,and the corresponding chemotherapy regimen was selected based on the outcomes.In the conventional group,Gemcitabine combined with Cisplatin was provided.The therapeutic effect was compared between the two groups.ResultsThe total effective rate of chemotherapy in the experimental group was 72.00%,which was obviously higher than that of the conventional group,and there was a statistical difference(P＜0.05).The quality of life in both groups was improved compared with that before chemotherapy,but there was no significant difference of PS score between the two groups(P＞0.05).In the experimental group,there were blood system reaction in 12 cases,digestive tract reaction in 7 cases,and other in 3 ones.In the conventional group,there were blood system reaction in 13 cases,digestive tract reaction in 7 cases,and other in 3 ones.There was no statistical difference of the incidence of adverse reaction between the two groups(P＞0.05).ConclusionTest for the level of ERCC1,BRCA1,and RRM1 and guidance of clinical treatment in NSCLC patients based on the outcomes are beneficial to improve the clinical therapeutic effect.
		2017 Vol. 24 (32): 56-58 [Abstract] ( 201 ) HTML (34 KB) PDF (0 KB) ( 85 )

	59	Clinical observation of TURBt in the treatment of high-risk invasive bladder cancer at advanced age
		CHEN Jun
		ObjectiveTo observe the clinical effect of TURBt in the treatment of invasive bladder cancer at advanced age.MethodsFrom August 2010 to July 2016,45 elderly patients with invasive bladder cancer treated in our hospital were enrolled and divided into the two groups.In the control group(n＝22),patients were provided with routine treatment,while in the observation group(n＝23),they were treated with TURBt.The total incidence of complications,operation time,intraoperative blood loss,and hospital stay were compared between the two groups.ResultsThe total incidence of complications of the observation group was 8.70%,which was lower than that of the control group(40.91%)(P＜0.05),the operation time was(51.45±1.18)min,the hospital stay was(9.36±1.08)d,which was shouter than those of the control group[(65.34±1.17)min,(15.45±0.27)d]respectively,and intraoperative amount of bleeding was(105.45±10.11)ml was fewer than that of the control group[(129.78±12.45)ml](P＜0.05).ConclusionFor elderly patients with invasive bladder cancer,application of TURBt can obtain a remarkable effect and prolong these patients′life,which is worthy of further promotion and application in clinic.
		2017 Vol. 24 (32): 59-60转63 [Abstract] ( 179 ) HTML (29 KB) PDF (0 KB) ( 67 )

	61	Effect observation of Recombinant Human Endostatin combined with Pemetrexed plusing Nadeplatin regimen advanced lung adenocarcinoma
		WANG Min;ZHAO Jian-hua
		ObjectiveTo observe the effect of Recombinant Human Endostatin combined with Pemetrexed plusing Nadeplatin regimen advanced lung adenocarcinoma.MethodsFrom March 2015 to January 2017,64 patients with advanced lung adenocarcinoma treated in our hospital were selected.The patients were divided into the study group (32 cases)and control group(32 cases)according to the admission order.The control group was treated with Pemetrexed combined with Nadeplatin,while the study group was treated with Recombinant Human EndostatinRecombinant Human Endostatin on the basis of the control group.After 2 courses of treatment,the treatment effect and incidence of adverse reactions in patients between the two groups were compared.ResultsThe total effective rate of treatment was 84.38%in the study group,which was significantly higher than that in the control group(56.25%)(P＜0.05).There was a significant difference in the incidence of adverse reactions of hemoglobin descent,nausea and vomiting between the two groups(P＜0.05),while there was no significant difference of white blood cell decline,fatigue between the two group (P＞0.05).ConclusionThe method of Recombinant Human Endostatin combined with Pemetrexed plusing Nadeplatin in the treatment of advanced lung adenocarcinoma has the advantages of high efficiency and less adverse reaction.
		2017 Vol. 24 (32): 61-63 [Abstract] ( 188 ) HTML (29 KB) PDF (0 KB) ( 42 )

	64	Evaluation on the efficacy of Leuprorelin Acetate pretreatment combined with laparoscopic myomectomy in the treatment of giant uterine fibroids
		LIAO Can
		ObjectiveTo investigate the clinical efficacy of Leuprorelin Acetate pretreatment combined with laparoscopic myomectomy in the treatment of giant uterine fibroids.Methods50 patients with giant uterine fibroids who were treated in our hospital from May 2014 to May 2016 were selected as subjects.According to the order of admission,the patients were divided two groups,30 cases in each group.The conventional group was directly given laparoscopic myomectomy,and the experimental group was given Leuprolide Acetate pretreatment before the surgical treatment.The volume of uterine fibroids were compared in the experimental group before and after the treatment,and the surgical conditions,postoperative recovery,the recurrence rate and the pregnancy rate of the two groups were compared.ResultsThe volume of uterine fibroids in the experimental group after treatment was significantly lower than that before treatment,and the difference was statistically significant(P＜0.05).The intraoperative blood loss in the experimental group was less than that in the conventional group,time of off-bed activity,pelvic drainage time and length of hospital stay in the experimental group were all significantly shorter than those in the conventional group,and the differences were statistically significant(P＜0.05).There was no significant difference between the two groups in recurrence rate and pregnancy rate(P＞0.05).ConclusionThe effect of Leuprolide Acetate combined laparoscopic myomectomy is significant in the treatment of patients with giant uterine fibroids,which is easy to reduce intraoperative blood loss,and shorten the length of hospital stay,and is conducive to early recovery.
		2017 Vol. 24 (32): 64-66 [Abstract] ( 183 ) HTML (32 KB) PDF (0 KB) ( 77 )

	67	Comparison of pathology and immune function of thymus in children with cyanotic and non-cyanotic congenital heart disease
		GUO Chen;AI Ling-yun;HU Shu-xia;YANG Wen-ping;KE Jiang-wei;MING Teng;ZOU Yong
		ObjectiveTo investigate the pathology and immune function of thymus in children with cyanotic and noncyanotic congenital heart disease,and to provide basis for the diagnosis and treatment of disease.Methods30 patients with cyanotic congenital heart disease(group A)and 40 patients with non-cyanotic congenital heart disease(group B)treated in our hospital from May 2016 to March 2017 were selected as subjects.The CD3,CD4,CD8,CD19,NK cells and cytotoxic T cells counts in two groups were detected and compared.The hist opathological changes of thymus in two groups were observed and compared.ResultsThe CD3,CD4,CD8,CD19,NK cells and cytotoxic T cells counts in group B were higher than those of group A,and the differences were significant(P＜0.05).The CD3,CD4,CD8,CD19,NK cells and cytotoxic T cells counts in children aged 1-2 years in both groups were lower than those of 0-1 years old children in the two groups,and the differences were significant(P＜0.05).Pathological examination resaults showed that both of the two groups had thymus structure exists,clear edge state,rich cortical lymphocytes,medullary thymus body structure exists,and no interstitial change,besides group B aged 1-2 years old children had small number of stars and thymus mild atrophy,group A aged 0-1 years old children had stars phenomenon and thymus mild atrophy,and group A aged 1-2 years old children had much stars and thymus atrophy.ConclusionThymic atrophy in children with cyanot-ic congenital heart disease are severe than that of the children with non-cyanotic congenital heart disease,and immune function in children with cyanotic congenital heart disease are lower than those of the children with non-cyanotic congenital heart disease.And the thymic atrophy and immune function lowering of children with congenital heart disease are aggravated with age.
		2017 Vol. 24 (32): 67-70 [Abstract] ( 222 ) HTML (37 KB) PDF (0 KB) ( 71 )

	71	Comparison of height,weight and BMI index between children with β marine anemia and normal children of the same age
		LUO Juan-juan;HUANG Mei-zhen
		ObjectiveTo investigate the difference between the height,weight and BMI index of children with β marine anemia and normal children of the same age.MethodsAltogether 52 cases of children with β marine anemia who were diagnosed by outpatient department in our hospital from June 2015 to June 2017 were selected as the observation group,and 52 normal children of the same age were randomly selected as the control group.The height,weight and BMI index of the two groups were compared.ResultsThe height,weight and BMI index of observation group were significantly lower than those of control group,and the differences were statistically significant(P＜0.05).Conclusionβ marine anemia affects the normal growth and development of children,which needs timely treatment or monitoring as well as intervention of height and weight growth if necessary.
		2017 Vol. 24 (32): 71-73 [Abstract] ( 148 ) HTML (30 KB) PDF (0 KB) ( 65 )

	74	Comparison the effect of intravenous indwelling needle puncture in different parts on parturient women
		SHU Wen-chao;ZHAO Yu-ting;TONG Zhi-hong
		ObjectiveTo investigate comparing the effect of intravenous indwelling needle puncture in different parts of parturient women and to analyze the application value of arm vein indwelling needle puncture in parturient women.Methods370 cases of parturient women who treated in our hospital for the implementation of intravenous indwelling needle puncture drug delivery from March 2016 to January 2017 were selected as research objects.The patients were divided into observation group(185 cases)and reference group(185 cases)according to the simple randomization method.The observation group was given intravenous puncture needle through forearm vein,and the reference group was treated with dorsal vein indwelling needle puncture.The one-time puncture success rate,hand movement status,transfusion patency,psychological status and comfort score of the two groups were compared and analyzed.ResultsThe one-time puncture success rate,hand movement status,transfusion patency and vaginal delivery rate in observation group were respectively 98.38%,96.76%,98.92 and 88.65%,which were respectively 86.49%,82.16%,88.65%and 80.00%in reference group,and the differences were statistically significant(P＜0.05).The anxiety and depression score of the observation group were significantly lower than those of the reference group,the comfort score of the observation group was much higher than that of the reference group,and the differences were statistically significant(P＜0.05).ConclusionCompared with dorsal vein indwelling needle puncture,hand vein indwelling needle puncture has obvious advantages in parturient women,which improve the success rate of puncture and maternal comfort,reduce maternal anxiety,ease the contradiction between doctors and patients,and is worth popularizing in clinical.
		2017 Vol. 24 (32): 74-76 [Abstract] ( 199 ) HTML (30 KB) PDF (0 KB) ( 61 )

	77	Application effect of balloon abdominal pressure belt in natural childbirth
		LI Hui;ZHOU Ping; LIAO Bi-ling ;ZENG Jun
		ObjectiveTo investigate the application effect of balloon abdominal pressure belt in natural childbirth.MethodsA total of 180 pregnant women who were in natural delivery in the department of obstetrics in our hospital from May 2016 to May 2017 were randomly divided into three groups,60 cases in each group.Group A was given abdominal pressure increasing midwifery device,group B was not given midwifery device for increasing abdominal pressure in the two courses of uterine construction,and group C was not given abdominal pressure increasing midwifery device.The changes in vital signs,neonatal Apgar score,bleeding volume,the duration of the second and third trimesters and the time of head visible on vulval gapping of three groups were compared.ResultsThe heart rate,respiration,systolic blood pressure,diastolic blood pressure and SpO2in 2 hours after delivery of three groups were compared,and the differences were not statistically significant(P＞0.05).The neonatal Apgar scores of three groups were compared,and the difference was not statistically significant(P＞0.05).The bleeding volume in the third trimester,bleeding volume upon delivery of placenta,and the postpartum bleeding volume in 2 hours after delivery in group A were less than those in group B,the indexes of group B were less than group C,and the differences were statistically significant(P＜0.05).The duration of the second trimester,the duration of the third trimester and the time of head visible on vulval gapping in group A were significantly less than those in group B,and the indexes of group B were significantly less than group C,the differences were statistically significant(P＜0.05).ConclusionThe multi-functional balloong abdominal pressure belt used in natural childbirth can speed up the duration of the second and third trimester,reduce the labor time and postpartum bleeding volume,and reduce the risk of postpartum hemorrhage.It has no significant adverse effects on maternal and infantile vital signs,with a positive clinical significance.
		2017 Vol. 24 (32): 77-79 [Abstract] ( 190 ) HTML (36 KB) PDF (0 KB) ( 63 )

	80	Effect comparison of hysteroscopic hydrotubation and conventional hydrotubation in the treatment of infertility
		DAI Jing-xi
		ObjectiveTo investigate the effect of hysteroscopic hydrotubationand conventional hydrotubation in the treatment ofinfertility,so as to provide basis for clinical practice.MethodsFrom January 2015 to January 2016,80 patients with infertility treated in our hospital were selected as subjects.Salpingography indicated they were all suffered from fallopian tube blockage at the proximal end.By the random number table method,they were evenly divided into control group and observation group,40 cases in each group.Patients in the control group were treated with conventional hydrotubation,and the patients in the observation group were treated by hysteroscopic hydrotubation.They were both provided with one-year follow-up visits after surgery.The intraoperative amount of bleeding,operation time,time to be off bed after surgery,andcurative effect were compared between the two groups.ResultsIn the observation group,the intraoperative amount of bleeding was greatly less than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in operation time or time to be off bed after surgery between the two groups (P＞0.05).The total effectiveness rate in the control group was 62.50%,it was significantly lower than that in the observation group accounting for 81.25%,and the difference was statistically significant(P＜0.05).The success rate of pregnancy in the observation group was 56.3%,which was significantly higher than that in the control groupaccouting for 37.5%,and the difference was statistically significant(P＜0.05).The average pregnancy time in the observation group was[(4.1±0.9)months],it was markedly shorter than that in the control group [(5.3±1.1)months],and the difference was statistically significant (P＜0.05).ConclusionCompared with conventional hydrotubation,hysteroscopic hydrotubation is more effective on treating fallopian tube blockage at the proximal end,and also more likely to be accepted by patients,which is worthy of further promotion.
		2017 Vol. 24 (32): 80-82 [Abstract] ( 172 ) HTML (31 KB) PDF (0 KB) ( 70 )

	83	Effect analysis of Budesonide Ultrasonic Atomization combined with Azithromycin in the treatment of Mycoplasma pneumoniae infection in children
		LIAO Ji-yan;LI Mu-lan;ZHANG Gui-hua
		ObjectiveTo investigate the clinical efficacy of Budesonide Ultrasonic Atomization combined with Azithromycin in the treatment of Mycoplasma pneumoniae infection in children,so as to provide a reference for the rational selection of treatment options.Methods78 children with Mycoplasma pneumoniae infection treated in our hospital from February 2016 to August 2017 were selected as the objects of observation,the random number table was used to divide them into two groups,each with 39 cases.The observation group was treated with Budesonide Ultrasonic Atomization combined with Azithromycin,and the control group was treated with Azithromycin alone.Two groups of treatment were 3 weeks.The clinical efficacy and adverse reactions of the two groups were observed after 3 weeks.ResultsThe total effective rate of the observation group was 94.87%,which was significantly higher than that of the control group(74.36%),the difference was statistically significant(P＜0.05).The disappeared time of wheezing breathing,fever,lung rales and cough in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P＜0.05).The incidence of adverse reactions in the observation group was 5.13%,which was significantly lower than that in the control group(15.38%),and the difference was statistically significant(P＜0.05).ConclusionBudesonide Ultrasonic Atomization combines with Azithromycin in children with Mycoplasma pneumoniae infection,can make the patient′s clinical symptoms,had better clinical curative effect,less adverse reaction,safe and reliable,and is worthy of popularization and application.
		2017 Vol. 24 (32): 83-85转89 [Abstract] ( 185 ) HTML (37 KB) PDF (0 KB) ( 80 )

	86	To explore the PCR-RFLP in testing the relationship between methylenetetrahydrofolate reductase gene polymorphism and the pathogenesis of pre eclampsia
		JIANG Xin;SHU Jun-jun;SHU Ru-ming;GONG Dan;YAN San-hua ;LI Li
		ObjectiveTo investigate the restriction fragment length polymorphism polymerase chain reaction(cleaved amplification polymorphism sequence-tagged sites,PCR-RFLP)in testing the relationship between methylenetetrahydrofolate reductase gene polymorphism and the pathogenesis of pre eclampsia,provide the basis for the prevention and treatment of preeclampsia.Methods100 preeclampsia (the case group)and 500 healthy pregnant women (the control group)from May 2016 to June 2017 treated in our hospital were selected as subjects to conduct polymorphism analysis of methylenetetrahydrofolate reductase gene and detect of gene polymorphism.Blood biochemical indexes were analyzed,basic data was investigated and factors were analyzed.ResultsAll cases were successfully sequenced in the case group,and 498 cases were successfully sequenced in the control group.The genotype frequency and allele frequency of the case group were compared,and the differences were statistically significant(P＜0.05).The the number of junior high school degree and below level,planned pregnancy,planned to control diet and nutritional supplements,folic acid,vitamin D supplements,the proportion of malnutrition were compared,and the differences were statistically significant(P＜0.05).APPT in the case group was lower than that in control group,and Hcy was higher than that in control group,the differences were statistically significant(P＜0.05).Logistic regression analysis was used for multivariate analysis.The results showed that allele TT,folic acid supplementation and planned exercise during pregnancy were independent risk factors(P＜0.05).There was significant correlation between TT type and Hcy and APPT(P＜0.05).ConclusionMethylenetetrahydrofolate reductase gene polymorphisms are associated with preeclampsia and have independent effects,which may be related to the elevation of Hcy.
		2017 Vol. 24 (32): 86-89 [Abstract] ( 139 ) HTML (34 KB) PDF (0 KB) ( 106 )

	90	Clinical observation of low temperature plasma adenoid radiofrequency ablation in the treatment of adenoid hypertrophy and tonsil in children
		SUN Xiao-yan; LIU Shi-hui;JU Xin-cui;QIAN Zhuo-ming
		ObjectiveTo investigate the clinical effect of adenoid echocardiography in the treatment of adenoid hypertrophy and tonsil in children.MethodsSixty patients with adenoid hypertrophy and tonsils treated in our hospotal from May 22,2015 to May 22,2016 were selected as subjects and were divided into observation group and control group,30 cases in each group.The patients of control group were treated with routine therapy and the patients of observation group were treated with adenoid radiofrequency ablation.The clinical symptoms score,total effective rate,recurrence rate,operation time,intraoperative blood loss,gland resection time and complication rate were compared between the two groups.ResultsIn the observation group,the time of gonadectomy and operation time were both shorter than the control group,the intraoperative blood loss was less than the control group,and the differences were statistically significant(P＜0.05).The incidence rate of complications and recurrence rate were lower than those in the control group,and the differences were statistically significant(P＜0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).After treatment,the symptom scores of all the children in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).ConclusionAdenoid radiofrequency ablation of adenoid hypertrophy children and tonsils can be performed to ensure the curative effect and improve the safety of treatment.
		2017 Vol. 24 (32): 90-92 [Abstract] ( 171 ) HTML (35 KB) PDF (0 KB) ( 71 )

	93	Analysis of the clinical effect of microscopic resection combined with conjunctival flap surgery in the treatment of refractory corneal ulcer
		HUANG Hai;YANG Tian; ZHANG Zhong-sheng
		ObjectiveTo investigate the clinical effect of microscopic resection combined with conjunctival flap surgery in the treatment of refractory corneal ulcer.Methods60 cases of refractory corneal ulcer from April 2015 to April 2017 in our hospital were randomly divided into the control group and the observation group,30 cases in each group.The control group was treated with routine medication,the observation group was treated with microscopic resection combined with conjunctival flap surgery.The clinical efficacy,the incidence rate of complications and visual acuity between the two groups were compared.ResultsThe cure rate of the observation group was 93.33%,which was higher than that of the control group(66.67%),the difference was statistically significant(P＜0.05).The incidence rate of secondary glaucoma,corneal perforation,corneal staphyloma,conjunctival flap partial dissolution,conjunctival flap perforation and conjunctival flap slippage in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).The visual acuity of the observation group after treatment was higher than that of the control group,the difference was statistically significant(P＜0.05).ConclusionThe clinical effect of microscopic resection combined with conjunctival flap surgery in the treatment of refractory corneal ulcer is significant,which can effectively save the eye,promote the improvement of visual acuity,low complication rate and high safety,it has positive clinical significance.
		2017 Vol. 24 (32): 93-95 [Abstract] ( 161 ) HTML (34 KB) PDF (0 KB) ( 65 )

	96	Effect analysis of diathermy of the sphenopalatine artery under nasal endoscope on treating intractable epistaxis
		JIANG Ze-bin
		ObjectiveTo explore the application effect of diathermy of the sphenopalatine artery under nasal endoscope in the treatment of intractable epistaxis.MethodsFrom June 2012 and May 2015,102 patients with intractable epistaxis treated in our department were selected.According to different therapeutic methods,they were divided into group A(56 cases)and group B (46 cases).Patients in group A were treated by diathermy combined with gauze packing,Patients in group B were treated by diathermy of the sphenopalatine artery under nasal endoscope.The hemostasis time,success rate of hemostasis,recurrence rate,postoperative ventilation function,olfactory function,and the incidence rate of complications were compared between the two groups.ResultsThe hemostasis time in group B was shorter than that in group A,with significant difference (P＜0.05).The success rate of hemostasis in group B was higher than that in group A,with significant difference(P＜0.05).The recurrence rate in group B was lower than that in group A,with significant difference(P＜0.05).There was no significant differencein the incidence of complications between the two groups(P＞0.05).The postoperative nasal olfactory function score,the total resistance of nasal ventilation in group B was lower than that in group A,with significant difference (P＜0.05).ConclusionDiathermy of the sphenopalatine artery under nasal endoscope in the treatment of intractable epistaxis is definite,which can completely stanch bleeding,with high success rate,it is worthy of clinical application and promotion.
		2017 Vol. 24 (32): 96-98转101 [Abstract] ( 145 ) HTML (34 KB) PDF (0 KB) ( 79 )

	99	Effect comparison of heat gutta-percha filling system and cold gutta-percha filling system in chronic periapical periodontitis
		MIAO Chen
		ObjectiveTo compare the effect of heat gutta-percha filling system and cold gutta-percha filling system in the treatment of chronic periapical periodontitis.Methods100 cases of chronic periapical periodontitis in our hospital from June 2015 to June 2016 were selected and randomly divided into the treatment group and the control group,50 patients in each group.The treatment group was treated with heat gutta-percha filling system,and the control group was treated with cold gutta-percha filling system.The difference of filling time,root filling effect,cure rate and postoperative pain rate between the two groups were compared.ResultsThere was no significant difference between the two groups in the filling effect(P＞0.05).The filling time of the treatment group was shorter than that of the control group,with significant difference (P＜0.05).After 6 months,the cure rate (92%)and the incidence rate of postoperative pain (6%)of the treatment group were significantly better than that of the control group(74%,22%),with significant difference(P＜0.05).ConclusionCompared with gutta-percha filling treatment,the effect of DIY heat gutta-percha filling in the treatment of chronic periapical periodontitis is more effective,and less adverse reactions,which is worthy of promoting in clinic.
		2017 Vol. 24 (32): 99-101 [Abstract] ( 181 ) HTML (29 KB) PDF (0 KB) ( 67 )

	102	Experiences in diagnosis and treatment of parasitic disease of naso-pharyngo-laryngea leeches under electron nosepharyngolarygnoscope
		YANG Wen-fei;PENG Yong-hua; LIU Xue-mei;LIU Jia-feng ;PENG Shao-ping
		ObjectiveTo investigate the clinical diagnosis and treatment characteristics of patients with naso-pharyngolaryngea leeches parasitic disease,to summarize the experience in treating naso-pharyngo-laryngea leeches under electronic nasopharyngolarygnoscope.MethodsThe clinical characteristics and treatment effect information of 11 cases of naso-pharyngo-laryngea leeches in our hospital from January to May in 2017 were retrospectively analyzed.ResultsNaso-pharyngo-laryngea leeches often occured in people who drank field unboiled water or had outdoor swimming.The leeches of 11 patients were all taken out under electron nasopharyngolarynoscope in a direct view.ConclusionThe naso-pharyngo-laryngea leeches tend to inhabit nasal cavity.It is effective and safe to take leeches out directly under the electron nosepharyngolarygnoscope.It is worthy of clinical promotion of the treatment.
		2017 Vol. 24 (32): 102-104 [Abstract] ( 153 ) HTML (31 KB) PDF (0 KB) ( 68 )

	105	Comparison of the application effect of assistant expansion arch and improved transverse palatalbar on maxillary arch expansion
		XIONG Bin1;ZHAO You-xin2;LUO Ming-le3
		ObjectiveTo explore the clinical application effect of assistant expansion arch and improved transverse palatalbar on maxillary arch expansion.MethodsFrom February 2015 to February 2017,48 cases of mild stenosis of maxillary arch needed to be treated by arch expansion in our hospital were selected and randomly divided into the assistant expansion arch group and the improved transverse palatalbar group,24 cases in each group.Two groups of patients were treated with assistant expansion arch and improved transverse palatalbar to expand maxillary arch.The width of dental arch before and after orthodontic treatment was compared between the two groups.ResultsThe first premolar of the arch width in the assistant expansion arch group after treatment was not significantly increased (P＞0.05),the first molar and the second premolar arch width expanded significantly,the difference were statistically significant(P＜0.05).The first premolar,the first molar and the second premolar the arch width in the improved transverse palatalbar group after treatment were significantly higher than that before treatment,and the difference were statistically significant(P＜0.05).After orthodontic treatment,the width of arch in the first molar of the improved transverse palatalbar group was significantly larger than that of the assistant expansion arch group,and the difference was statistically significant(P＜0.05),but there was no significant difference in the rest of the teeth (P＞0.05).ConclusionAssistant expansion arch and improved transverse palatalbar expansion for maxillary mild to moderate stenosis patients have good expansion effect,which can choose suitable methods according to the different characteristics of the cases.
		2017 Vol. 24 (32): 105-107转111 [Abstract] ( 172 ) HTML (33 KB) PDF (0 KB) ( 72 )

	108	Influence of continuous infusion of Esmolol on hyperalgesia in patients undergoing laparoscopic cholecystectomy after induction of anesthesia with Remifentanil
		PENG Juan;ZHOU Yan;WANG Ning-ping
		ObjectiveToobserveandanalyzetheeffectofcontinuousinfusionofEsmololonhyperalgesiainpatientsundergoing laparoscopic cholecystectomy after induction of anesthesia with Remifentanil.Methods88 patients undergoing elective laparoscopic cholecystectomy in our hospital from February 2015 to April 2016 were selected.According to the admission order,the patients were divided into the study group and the control group,with 44 patients in each group.The patients in the control group were given intravenous injection of normal saline before induction of anesthesia and the infusion was continued until the immediate time point of removing the tracheal tube.Patients in the study group were given equal amounts of Esmolol for continuous infusion.The changes of signs,the dosage of Remifentanil,tracheal extubation time and postoperative adverse reactions were recorded and compared between the two groups.ResultsMAP and HR at the time of tracheal intubation (T1)and at the time of extubation (T3)were significantly higher than those before anesthesia induction(T0)in the control group,with significant difference(P＜0.05).The MAP and HR in the study group at T1and T3were significantly lower than those in the control group,with significant difference(P＜0.05).The VSA scores in the study group at 2,6,12,24 h after surgery were significantly lower than those in the control group,with significant difference (P＜0.05).The time of tracheal extubation and the dosage of Remifentanil in the study group were significantly lower than that in the control group,with significant difference(P＜0.05).The incidence rate of postoperative nausea and vomiting in the study group was (4.55%),which was significantly lower than that in the control group(25.00%),and the differences were significant (P＜0.05).ConclusionPerioperative administration of Esmolol in the patients undergoing laparoscopic cholecystectomy can safely and effectively reduce the hyperalgesia induced by Remifentanil anesthesia induction.The dosage of Remifentanil is reduced intraoperatively,hemodynamic stability in patients is maintained,and the incidence rate of nausea and vomiting is lowered.
		2017 Vol. 24 (32): 108-111 [Abstract] ( 175 ) HTML (37 KB) PDF (0 KB) ( 66 )

	112	Effect of Nalbuphine in pediatric daytime operation pain in nursing
		LIU Pei-zhen
		ObjectiveTo explore the effect of Nalbuphine in pediatric daytime operation pain in nursing.Methods136 cases of the children with unilateral hernia sac high ligation under general anesthesia in daytime operating room of Guangzhou Women and Children′s Medical Center from March to December in 2016 were selected and randomly divided into the Sufentanil group(69 cases)and the Nalbuphine group(67 cases).Patients of the Sufentanil group were given 3 ug/kg of Sufentanil,while patients of the Nalbuphine group were given 0.3 mg/kg of Nalbuphine for the induction of general anesthesia,and the patients were given placement of laryngeal mask.After operation,patients were transported to the PACU with laryngeal mask.After removal of laryngeal mask,the patients were observed for 3 h accompanied by parents.FLACC pediatric pain scale and Ramsay sedation scale were adopted to record the children′s sedation and analgesia conditions immediately after the removal of laryngeal mask(T0),1 h after removal of laryngeal mask(T1),2 h after removal of laryngeal mask (T2)and 3 h after removal of laryngeal mask (T3).The occurrence of adverse reactions during the recovery period was recorded.ResultsThe children pain scores of the Nalbuphine group at T0were higher than that of the Sufentanil group,with significant difference (P＜0.05).While the sedation scores of the Nalbuphine group at T0,T1and T2were lower than that of the Sufentanil group,with significant difference (P＜0.05).Compared with the Sufentanil group,the incidence of hypoxemia,nausea and vomiting during the recovery period was obviously decreased in the Nalbuphine group,with significant difference(P＜0.05),while there was no statistically significant difference in the incidence of other adverse effects(P＞0.05).ConclusionNalbuphine can produce longer analgesic duration than Sufentanil,and can effectively reduce the incidence of agitation and postoperative adverse reaction during the recovery period,which is appropriate for postoperative pain management of children daytime operation.
		2017 Vol. 24 (32): 112-114 [Abstract] ( 177 ) HTML (35 KB) PDF (0 KB) ( 62 )

	115	Influence of different anesthesia methods on postoperative short-term cognitive function in elderly patients with department of orthopedics
		XIONG Kai1;WU Zhi-ying2
		ObjectiveTo investigate the effect of different anesthesia methods on short-term cognitive function in elderly patients with department of orthopedics.Methods58 elderly patients undergoing department of orthopedics surgery from January 2014 to January 2017 were divided into the combined spinal anesthesia(CSEA)group(n=30)and the general anesthesia(GA)group(n=28)according to different anesthesia methods.The cognitive ability of the two groups of patients after anesthesia 6,12,24,72 h were recorded.The changes of blood pressure(BP)and heart rate(HR)before and after anesthesia were observed,and the occurrence of post operative cognitive dysfunction(POCD)was compared.ResultsThe MMSE scores of 6,12 h after anesthesia were compared with those before anesthesia in group CSEA,the difference was statistically significant(P＜0.05).The MMSE scores of 6,12,24 h after anesthesia were compared with those before anesthesia in group GA,and the difference was statistically significant(P＜0.05).The MMSE score of the 24 h in group CSEA and the GA group after anesthesia were statistically significant(P＜0.05).There was no significant difference in the level of BP and HR between the two groups before and after anesthesia(P＞0.05).The incidence of POCD after anesthesia in group CSEA was lower than that in group GA,and the difference of POCD between two groups of 6,12 h after anesthesia was statistically significant(P＜0.05).ConclusionThe short-term cognitive function of combined spinal anesthesia in elderly department of orthopedics patients is significantly less than general anesthesia,and the side effects are relatively small.
		2017 Vol. 24 (32): 115-117转120 [Abstract] ( 189 ) HTML (34 KB) PDF (0 KB) ( 69 )

	118	Application values of Isoflurane and Sevoflurane compound in children general anesthesia
		YE Xiao-fei
		ObjectiveTo study the effects of Isoflurane and Sevoflurane compound in children with general anesthesia.MethodsFrom October 2015 to June 2017,120 cases of surgical children in our hospital were selected and divided into the control group(Isoflurane general anesthesia)and the study group(Isoflurane+Sevoflurane combined anesthesia)according to the order of admission,with 60 cases in each group.The anesthesia effects,the hemodynamic indicators and adverse reactions were compared between the two groups.ResultsThe time of induction of anesthesia,postoperative recovery time and Aldrete score≥9 minutes in the study group were significantly lower than that in the control group,the difference was statistically significant(P＜0.05).The incidence of the respiratory depression,nausea,vomiting,cough and restlessness in the study group during anesthesia and after awakening were significantly lower than those in the control group,the difference was statistically significant(P＜0.05).After admission and tracheal intubation,the level of MAP and HR in the study group were significantly lower than those in the control group,the difference was statistically significant(P＜0.05).ConclusionThe combination of Isoflurane and Sevoflurane in general anesthesia in children can significantly shorten the induction time of anesthesia,postoperative recovery time and recovery time,help to maintain hemodynamic stability,which is significantly reduce the incidence of adverse reactions,it is worthy of clinical application.
		2017 Vol. 24 (32): 118-120 [Abstract] ( 175 ) HTML (31 KB) PDF (0 KB) ( 58 )

	121	Comparison on Addingalogliptin or Glimepiride in poorly controlled in patients with type 2 diabetes with oral Metformin
		ZHONG Shu-mei;ZHANG Si-qing
		ObjectiveTo compare the efficacy between Alogliptin and Glimepiride in poorly controlledin patients with type 2 diabetes(T2DM)with oral Metformin.Methods60 in poorly controlled in patients with T2DM with oral Metformin in our hospital from March 2014 to March 2016 were randomized into two groups of receiving Alogliptin with Metformin(A group,30 cases)and Glimepiride with Metformin(B group,30cases)for 24 weeks.The changes of BMI,TC,G,HDL-C,LDL-C,FBG,HOMA-IR and Hypoglycemic were observed.ResultsAfter 24 weeks treatment,the FBG,2 h PG and HbA1c were significantly reduced compared with their pre-treatment(P＜0.05)in two groups,and there was significant difference between the two groups(P＜0.05).The HOMA-IR of the two groups were decreased significantly before treatment,but there was no significant difference between the groups(P＞0.05).The TC,TG,LDL-C and BMI of A group as bviously decreased and HDL-C was significantly increased than before treatment(P＜0.05),there was no significant difference in B group.There was no hypoglycemia occurs in A group,but two case was happened in B group.ConclusionCombined with Alogliptinor Glimepiridein poorly controlledin patients with T2DM with oral Metformin can significantly improve the patient′s blood glucose,body weight and insulin resistance.Different treatment options can be used depending on the patient′s differences.
		2017 Vol. 24 (32): 121-123 [Abstract] ( 175 ) HTML (30 KB) PDF (0 KB) ( 79 )

	124	The clinical effects research of treatment COPD stabilization by Atorvastatin Calcium
		LIU Zheng;HE Min;LI Jin
		ObjectiveTo approach clinical effects of treatment COPD stabilization by Atorvastatin Calcium.MethodsThe 120 cases clinical data of COPD stabilization patients in our hospital from January 2015 to February 2017 were analyzed,which was divided into two group by different treatment methods,routine treatment group(routine treatment)60 cases and experimental group(Atorvastatin Calcium treatment)60 cases.The blood gas analysis result,6MWT and lung function of two group COPD stabilization patients before treatment and after treatment were detected.ResultsThe PaO2,PaCO2,6MWT,FEV1,FEV1/FVC,FEV1%Pred of two group COPD stabilization patients before treatment were no difference(P＞0.05),the PaO2,6MWT,FEV1,FEV1/FVC,FEV1%Pred of routine treatment group and experimental group after treatment were higher than before treatment,PaCO2was lower than before treatment,the PaO2,6MWT,FEV1,FEV1/FVC,FEV1%Pred of experimental group after treatment were higher than routine treatment group,PaCO2was lower than routine treatment group,the difference were statistical significance(P＜0.05).ConclusionThe COPD stabilization by Atorvastatin Calcium,which could improve blood gas analysis,increase lung function,it is worth to be used.
		2017 Vol. 24 (32): 124-126 [Abstract] ( 160 ) HTML (35 KB) PDF (0 KB) ( 80 )

	127	Observation of effect of Lactobacillus Complex Capsules on diarrhea predominant irritable bowel syndrome
		HE Gui-ming;MO Bi-hua;HUANG Zheng;HUANG Xue-qin
		ObjectiveTo observe the feasibility and effectiveness of Lactobacillus Complex Capsules in the treatment of diarrhea predominant irritable bowel syndrome(IBS).MethodsAltogether 105 cases of patients with diarrhea predominant IBS who were treated in our hospital from July 2015 to December 2016 were selected as the subject of this observation and divided into two groups according to clinical treatment,including 51 cases in the control group(treated with medications Berberine hydrochloride+Montmorillonite powder)and 54 cases in the study group(Lactobacillus Complex Capsules+Montmorillonite powder+Berberine hydrochloride).The improved time of diarrhea,abdominal distension and abdominal pain symptoms was compared statistically;assessment of two groups of IBS treatment,medication adverse events recorded during treatment,follow-up recurrence 6 months the number of disease statistics.Resultsthe cure rate and the recurrence rate was 96.3%,5.5%,84.3%in the control group,15.7%group comparison study group treatment effect,low recurrence rate,the difference was statistically significant(P＜0.05);adverse event statistics,the study group the incidence rate was 11.1%compared with the control group 7.8%,the difference was not statistically significant(P＞0.05);the study group diarrhea,abdominal distension,abdominal pain symptoms improved with time was shorter than the control group,the difference was statistically significant(P＜0.05).ConclusionThe clinical use of Lactobacillus Complex Capsules in the treatment of diarrhea type IBS patients is good,the disease recurrence rate is low,the symptoms are improved and the time is short.
		2017 Vol. 24 (32): 127-129 [Abstract] ( 143 ) HTML (33 KB) PDF (0 KB) ( 70 )

	130	Protective effect of S-adenosylmethionine on acute liver function lesion after transcatheter arterial chemoembolization in the patients with primary hepatocellular carcinoma
		ZENG Xiao-yi
		ObjectiveTo analyze the protective effect of S-adenosylmethionine on acute liver function lesion after transcatheter arterial chemoembolization(TACE)in the patients with primary hepatocellular carcinoma.Methods80 patients with primary hepatocellular carcinoma who were admitted in our hospital and treated by TACE from January 2015 to January 2017 were selected as the study subjects.According to the comprehensive randomized sequential method,the patients were divided into 40 cases in the control group and 40 cases in the observation group.The control group was given routine hepatoprotective therapy,including TACE treatment,gantaile tablets+Vitamin C+creatinine injection and other drug intervention.The observation group was given S-adenosylmethionine after the treatment on the basis of the control group.The changes of liver function were compared between the two groups at different time points before and after treatment.ResultsAfter treatment,the liver function indices in the two groups were compared and the differences were not statistically significant(P＞0.05);the level of liver function indices in the observation group 7 d after the treatment was lower than that in the control group,and the difference was statistically significant(P＜0.05);the satisfaction rate with treatment in the observation group was significantly higher than that in the control group,and the results were significantly different(P＜0.05).ConclusionS-adenosylmethionine intravenous infusion can be used to alleviate the acute liver function injury and promote the recovery of liver function in patients with hepatocellular carcinoma after TACE.
		2017 Vol. 24 (32): 130-132 [Abstract] ( 140 ) HTML (32 KB) PDF (0 KB) ( 63 )

	133	Effect of Trimetazidine combined with Atorvastatin on coronary heart disease and lower blood lipid
		ZHANG Shu-xia
		ObjectiveTo explore the effect of Trimetazidine（TMZ） combined with Atorvastatin in the treatment of coronary heart disease and lower blood lipids.MethodsFrom September 2015 to October 2016,a total of 73 patients with hyperlipidemia and coronary heart disease who were treated in our hospital were selected and divided into observation group and control group by random grouping.The observation group were consisted of 37 patients and the control group of 36 cases.The control group was given oral TMZ on the basis of conventional therapy for two courses.The observation group was treated with oral TMZ combined with Atorvastatinfor two courses.After treatment,the clinical outcomes and adverse reactions were compared，meanwhile,the results of relevant indicators of serum lipid levels and serum creatinine,urea nitrogen and 24 h urine protein of two groups of patients before and after treatment were compared.ResultsAfter treatment，the total effective rate of clinical treatment of coronary heart disease in the observation group was higher than that in the control group,the incidence of adverse reactions was lower than that of the control group,the difference was statistically significant(P＜0.05);after treatment,the observation group of patients with lipid levels were lower than the control group,the difference was statistically significant(P＜0.05).Serum creatinine and urine nitrogen levels of two groups were compared,the difference was not statistically significant(P＞0.05),the level of 24 h urinary protein in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).ConclusionCompared with control group,observation group has a better clinical effect,the use of TMZ combined with Atorvastatin can lower blood lipids and get better results，it is recommended to promote the use of clinical.
		2017 Vol. 24 (32): 133-135 [Abstract] ( 194 ) HTML (34 KB) PDF (0 KB) ( 53 )

	136	Influence of Oxaliplatin+Tegafur chemotherapy combined with Ziyin Jianpi Quyu Decoction on therapeutic effect,quality of life,and immunological indexes in patients with advanced gastric cancer
		ZOU Cai-liang;WANG Hong-yun;WU Yan-ling;XIA Xiao-long
		ObjectiveTo analyze the influence of Oxaliplatin+Tegafur chemotherapy combined with Ziyin Jianpi Quyu Decoction on therapeutic effect,quality of life,and immunological indexes in patients with advanced gastric cancer.MethodsFrom January 2014 to January 2017,44 patients with advanced gastric cancer treated in our hospital were enrolled.By randomized integrated and sequent therapy,they were eveny divided into control group and observation group,and there were 22 cases in each group.Both groups were provided with Oxaliplatin and Tegafur.In the observation group,Ziyin Jianpi Quyu Decoction was added besides.The therapeutic effective rate,score of quality of life,and immunological indexes were compared between the two groups.ResultsThe therapeutic effective rate in the observation group was higher than that in the control group (P＜0.05).The indexes of physiological factor and social relation from QOLBREF scale in the observation group were superior to those in the control group (P＜0.05).After therapy,the indexes of CD4+and CD3+were both better than those in the control group with statistical differences(P＜0.05).ConclusionIn the treatment of advanced gastric cancer,application of Oxaliplatin+Tegafur chemotherapy combined with Ziyin Jianpi Quyu Decoction can improve the quality of life,immune function,as well as therapeutic effect,and reduce the toxic and side effects,which is worthy of clinical promotion.
		2017 Vol. 24 (32): 136-138 [Abstract] ( 142 ) HTML (32 KB) PDF (0 KB) ( 60 )

	139	Clinical study of integrated traditional Chinese and Western medicine treating chronic obstructive pulmonary disease complicated with depression
		LI Ping
		ObjectiveTo observe the clinical effect of integrated traditional Chinese and western medicine treating chronic obstructive pulmonary disease (COPD)complicated with depression.MethodsPatients treated by a community hospital of Chengdu city from October 2014 to April 2016 were selected.64 patients with COPD complicated with depression were randomly divided into the treatment group (38 cases)and control group (26 cases)with the aid of SAS statistical analysis software.The control group was treated with conventional Western medicine,while the treatment group was treated with Jiawei Xiaoyao Powder on the basis of the control group.The total effective rate,HAMD score and pulmonary function index between the two groups were analyzed.ResultsAfter 8 weeks treatment,the total effective rate was 82.56%in the treatment group and it was 69.23%in the control group,and the difference between the two groups was statistically significant(P＜0.05).HAMD score after 6 and 8 weeks treatment in the treatment group was significantly lower than those in the control group (P＜0.05).After 8 weeks treatment,the FEV1%of the treatment group was better than that of the control group(P＜0.05),and the difference of FVC%between the two groups was not statistically significant(P＞0.05).ConclusionJiawei Xiaoyao Powder combined with conventional western medicine has much better clinical effect treating COPD complicated with depression.
		2017 Vol. 24 (32): 139-141 [Abstract] ( 176 ) HTML (36 KB) PDF (0 KB) ( 69 )

	142	Effect observation of integrated traditional Chinese and western medicine in treatment of diabetic renal failure
		TAO Jun
		ObjectiveTo observe the effect of combination of integrated traditional Chinese and Western medicine in treatment of diabetic renal failure.Methods88 patients with diabetic renal failure treated in our hospital from February 2015 to February 2017 were selected and randomly divided into the control group (n＝44)and study group (n＝44).The control group was treated with conventional Western medicine treatment,while the study group was given traditional Chinese medicine decoction on the basis of the control group.The clinical effect in patients between the two groups was compared.ResultsThe total effective rate of the study group was 90.91%,which was significantly higher than that of the control group (63.64%),with significant difference between the two groups (P＜0.05).The post-treatment fasting blood glucose,serum creatinine,24 h urine protein and urea nitrogen of two groups were significantly improved in comparison with those before treatment(P＜0.05),and compared to the control group,the degree of improvement of the study group was more obvious,with significant differences between the two groups (P＜0.05).ConclusionIntegrated traditional Chinese and western medicine in treatment of diabetic renal failure in the treatment of diabetic renal failure is effective,and its clinical value is worthy of recognition.
		2017 Vol. 24 (32): 142-144 [Abstract] ( 147 ) HTML (30 KB) PDF (0 KB) ( 61 )

	145	Study on the therapeutic effect of Huangqi Injection combined with antituberculosis drug on tuberculosis
		CHEN Fang;HUANG De-chang
		ObjectiveTo investigate the therapeutic effect of Huangqi Injection combined with anti-tuberculosis drug on tuberculosis.Methods87 patients given tuberculosis treatment in our hospital from January 2016 to January 2017 were selected as the subjects,and they were divided into the control group (n＝43)and observation group (n＝44).The control group was treated with anti-tuberculosis western medicine alone.The observation group was treated with Huangqi Injection on the basis of anti-tuberculosis treatment in the control group.The curative effect was compared in patients between the two groups.ResultsAfter 3 months treatment,the sputum negative rate in patients of the observation group(93.18%)was significantly higher than that in the control group(65.12%),and there was a significant difference between the two groups(P＜0.05).After 6 months treatment,the total absorption rate of lesion in patients of the observation group(93.18%)was significantly higher than that in the control group(74.42%)(P＜0.05).Void closure rate in patients of the observation group(86.36%)was significantly higher than that in the control group(69.77%),and the incidence of adverse reactions in the observation group (6.82%)was significantly lower than that in the control group(16.28%),and there was a significant difference between the two groups(P＜0.05).ConclusionHuangqi Injection combined with anti-tuberculosis drugs applied in patients with tuberculosis,and its sputum negative conversion rate,the total absorption rate of lesion and void closure rate were higher,and the incidence of adverse reactions was lower.It is worthy of clinical reference and promotion.
		2017 Vol. 24 (32): 145-147 [Abstract] ( 159 ) HTML (32 KB) PDF (0 KB) ( 83 )

	148	Clinical effect of integrated traditional Chinese and western medicine treating osteoporosis used by SONG Lin-xuan of the famous veteran teran doctors of TCM
		LIN Mao-gui;SONG Lin-xuan
		Objectiveto explore the curative effect of integrated traditional Chinese and western medicine treating osteoporosis used by SONG Lin-xuan,to summarize the treatment experience.MethodsAltogether 120 patients with osteoporosis treated in our hospital from January 2015 to December 2016 were divided into the western medicine group (n＝60)and combination group(n＝60)according to the random number table method.Patients in the western medicine group were given oral Allen Sodium Phosphate Tablets,based on the treatment of western medicine group,patients in the combination group were given Bushen Huoxue Prescription.The treatment of two groups of patients lasted for 45 consecutive days.The treatment effect and McGill pain score,quality of life score and laboratory index before and after treatment in patients between the two groups were compared.ResultsAfter treatment,the curative effect,McGill pain and quality of life of the two groups were significantly improved (P＜0.05),and the improvement degree of the combination group was significantly better than that of the western medicine group (P＜0.05).ConclusionIntegrated traditional Chinese and western medicine treating osteoporosis used by SONG Lin-xuan has good effect on improving the clinical symptoms of osteoporosis patients,and can effectively treat osteoporosis.
		2017 Vol. 24 (32): 148-151转155 [Abstract] ( 178 ) HTML (44 KB) PDF (0 KB) ( 66 )

	152	Clinical effect of Dachengqi Decoction as an external application combined with conventional regimen in the treatment of severe acute pancreatitis
		XIONG Xiao-yan;TAN Shi-yun;WANG Yong
		ObjectiveTo study the clinical effect of Dachengqi Decoction as an external application combined with conventional therapy on severe acute pancreatitis(SAP)and its influence on serum C-reactive protein(CRP)and procalcitonin (PCT).MethodsFrom June 2010 to February 2016,60 SAP patients treated in Department of Gastroenterology in Hanchuan People′s Hospital were randomly divided into the control group(n＝30)and experimental group(n＝30).In the control group,conventional regimen was used,while in the experimental group,besides the conventional regimen,Dachengqi Decoction as an external application was added.The courses of treatment lasted 14 days in the two groups.The remission time of abdominal pain and distension,recovery time of bowel sound,time to defecate,and hospital stay and cost were recorded.The blood amylase (AMY),CRP,and PCT before and after treatment were tested.ResultsThe overall effective rate was 96.67%in the experimental group,which was higher than that in the control group (83.33%)(P＜0.05).In the experimental group,the remission time of abdominal pain and distension,recovery time of bowel sound,defecation time,time of blood routine,blood and urine AMY being normal were all shorter compared with those in the control group (P＜0.01).The hospital stay in the experimental group was shorter than the control group,and the hospitalization cost was lower in the experimental group (P＜0.01).The level of CRP and PCT and score of Ranson,APACHEⅡ,and CT in the experimental group were significantly lower than those in the control group (P＜0.01).ConclusionCombination of Dachengqi Decoction as an external application and conventional regimen can remarkably improve clinical symptoms including abdominal pain and distension,and intestinal paralysis,etc.at an acute stage in SAP patients,decrease the level of CPR and PCT,alleviate systemic damage due to inflammation of pancreas,and is beneficial to the rehabilitation of disease.
		2017 Vol. 24 (32): 152-155 [Abstract] ( 146 ) HTML (45 KB) PDF (0 KB) ( 59 )

	156	ClinicaleffectanalysisofintegratedtraditionalChineseandwesternmedicine treating acute gouty arthritis
		LIU Lin-hai
		Objectiveto analyze the clinical effect of integrated traditional Chinese and western medicine treating acute gouty arthritis.Methods102 patients with acute gouty arthritis treated in our hospital from April 2016 to April 2017 were selected as the subjects.According to the random number method,they were divided into the control group(51 cases,a single western medicine treatment)and observation group(51 cases,integrated traditional Chinese and western medicine treatment).The total effective rate of symptom improvement,serum uric acid,ESR and C-reactive protein between the two groups were compared.ResultsThe total effective rate of symptom improvement in the observation group was 96.1%,which was higher than that of the control group (74.5%),and the difference was statistically significant(P＜0.05).The serum uric acid,ESR and C-reactive protein level in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P＜0.05).ConclusionThe effect of integrated traditional Chinese and western medicine treating acute gouty arthritis is obvious,and can effectively improve the clinical symptoms of patients.It is worthy of promotion.
		2017 Vol. 24 (32): 156-158 [Abstract] ( 151 ) HTML (30 KB) PDF (0 KB) ( 69 )

	159	A study on the correlation between self-efficacy of emotional regulation and anxiety in college students in Foshan
		LIANG Zhen-tao;YANG Yu;GAO Li-juan;YU Cui-fang;LIANG Zhi-feng
		ObjectiveTo analyze the correlation between self-efficacy and anxiety according to the investigation on the current situation of self-efficacy of emotional regulation in the college students in Foshan,so as to provide a theoretical basis for improving the mental health levels of college students.MethodsFrom December 2016 to May 2017,a total of 342 college students from 4 universities in Foshan,Guangdong were selected as the study subjects.The questionnaire of general data,the students′emotional regulation self-efficacy scale,and anxiety self-rating scale were applied and data were collected.The correlation between the two was analyzed.ResultsThe total score of self-efficacy of emotional regulation was(62.06±5.45)in 342 college students in Foshan.There were 47 people(13.74%)with anxiety.The differences in the scores of expressing positive emotion dimension(t=2.92,P=0.01),management of frustration/anger dimension(t=2.68,P=0.01)and total score of self-efficacy of emotional regulation were statistically significant in the students with different anxiety levels(t=3.84,P=0.00);the score of anxiety self-rating scale in college students was negative correlated with the scores of expressing positive emotion dimension (r=-0.26,P=0.00),management of frustration/pain dimension(r=-0.14,P=0.01),and total score of self-efficacy of emotional regulation(r=-0.26,P=0.00).ConclusionThe overall level of self-efficacy of emotional regulation in the college students in Foshan is moderate to superior,which can reduce the occurrence of anxiety by improving the self-efficacy of emotional regulation in college students.
		2017 Vol. 24 (32): 159-161 [Abstract] ( 172 ) HTML (32 KB) PDF (0 KB) ( 62 )

	162	Investigation and analysis of Helicobacter pylori infection in healthy people
		CHENG Ying
		ObjectiveTo investigate the infection status of Helicobacter pylori(Hp)in healthy people,analyze Hp infection-related influencing factors,and put forward countermeasures.MethodsA total of 235 healthy subjects who were given physical examination from January 2016 to January 2017 were randomly selected as subjects.Carbon-14 breath card test method was adopted for all health subjects to conduct Hp infection survey.At the same time,self-made questionnaire was used for the subjects to conduct daily situations.The observation indicators included the occurrence of Hp infection in healthy subjects,Hp infection-related factors,Hp infections in different age groups.ResultsA total of 115 patients with positive Hp were detected in 235 healthy subjects,accounting for 48.94%,the infection rate of Hp was 56.67%in the age group≥50 years old,which was significantly higher than that in the age group＜50 years old (35.29%)(P＜0.05);the infection rate of Hp was 65.93%in the drinking population,which was significantly higher than that of 26%in small drinking amount or non-drinking population(P＜0.05);the infection rate of Hp in smoking population was 60.39%,which was significantly higher than that of 27.16%in non-smokers(P＜0.05);the infection rate of Hp in patients with coronary heart disease and diabetes mellitus was significantly higher than that in patients without coronary heart disease and diabetes mellitus，the difference was statistically significant(P＜0.05).The infection rate of Hp in hypertensive population was 49.19%,and the infection rate was 50.81%in non-hypertensive population.There was no significant difference(P＞0.05).After a multivariate analysis,it was found that smoking(OR＝9.943,P＝0.045)and age≥50 years old(OR＝6.132,P＝0.039)were independent risk factors for Hp infection in healthy subjects.ConclusionHp infection in healthy people is closely related to poor living habits,history of diabetes mellitus,history of coronary heart disease and age.Smoking and age≥50 years old are independent risk factors for Hp infection in healthy people.
		2017 Vol. 24 (32): 162-164 [Abstract] ( 155 ) HTML (33 KB) PDF (0 KB) ( 68 )

	165	Study on construction of competency based training syllabus for disaster rescue capability of nursing students in colleges and universities
		DAI Yue;CAI Lan-ying
		ObjectiveTo explore the training syllabus for the disaster rescue capability of college nursing students suitable for China′s national conditions,which has guiding significance for various common disaster relief practices,according to taking competency education as the training mode and the rescue demand based on the disaster events as the foundation.Methods23 disaster nursing consultation experts from January to March in 2016 were selected as the research object according to Delphy (Delphi)consultation,and conducted two rounds of expert consultation to formulate a scientific and standardized disaster rescue capability training syllabus.ResultsTwo rounds of expert questionnaire inquiry effective recovery rate was over 90%,the expert authority coefficient average score was more than 0.7,coordinate coefficient of expert opinion by 2 test was significant difference(P＜0.05),eventually the disaster rescue ability of college nursing students training program included 11 training programs,49 training content and the corresponding target and 96 hours.ConclusionThe research for the authority of experts and expert opinion coordination are higher,the establishment of the disaster rescue ability training program of nursing students has very strong practicability and operability.
		2017 Vol. 24 (32): 165-167 [Abstract] ( 144 ) HTML (33 KB) PDF (0 KB) ( 68 )

	168	Application effects of micro-lesson combined with PPT multimedia teaching mode in the nursing teaching of cardiothoracic surgery
		YE Wang-qin
		ObjectiveTo investigate the effect of micro-lesson combined with PPT multimedia teaching mode in the nursing teaching of cardiothoracic surgery.Methods86 nursing students of cardiothoracic surgery nursing practiced in our academy from September 2015 to July 2016 were selected,and they were divided into the control group and the observation group by random number table method,43 cases in each group.The control group was given traditional PPT multimedia teaching mode,while the observation group was given micro-lesson on the basis of the control group.The test scores were compared between the two groups.The evaluation of teaching effect of micro-lesson in the observation group was analyzed.ResultsThe scores of operating skill and theoretical knowledge in the observation group were significantly higher than that in the control group,with significant difference(P＜0.05).In the observation group,nursing students considered that micro-lesson could increase autonomous learning ability and grasp difficult knowledge,which accounted for 97.67%,95.35%of nursing students considered that micro-lesson was suitable for after-school autonomous learning,93.02%of nursing students considered that micro-lesson could deepen understanding of operation and increase learning efficiency,90.70%of nursing students considered that micro-lesson was effective supplement of traditional teaching,and 88.37%of nursing students considered that micro-lesson could motivate learning interest.ConclusionMicro-lesson combined with PPT multimedia teaching mode in the nursing teaching of cardiothoracic surgery can increase teaching effects.
		2017 Vol. 24 (32): 168-170 [Abstract] ( 129 ) HTML (31 KB) PDF (0 KB) ( 66 )

	171	Influence of Doula nursing on delivery outcome inprimiparae
		XIONG Hua-lan
		ObjectiveTo explore the influence of Doula nursing on the delivery outcome in primiparae.Methods94primiparae treated were enrolled from May 2015 to February 2017 in our hospital,by an odd/even number,they were divided into two groups.In the control group,routine nursing intervention was used,while in the experimentalgroup,on the basis of the conventional nursing,Doula nursing was adopted.The of duration of labor,prenatal psychological state,amount of bleeding after delivery,neonatal Apgar score,andvaginal delivery rate,etc.were observed and compared in both groups.ResultsIn the control group,the duration of labor and prenatal mental state were greatly higher than those in the experimental group （P＜0.05).The neonatal Apgar score and vaginal delivery rate in the experimental group were higher compared with those in the control group （P＜0.05).ConclusionThe implementation of Doula nursing for primiparaenot only increases the vaginal delivery rate,but also improves their negative emotion and shortens the labor duration.
		2017 Vol. 24 (32): 171-173 [Abstract] ( 157 ) HTML (33 KB) PDF (0 KB) ( 64 )

	174	Correlation of blood glucose control with humanistic care and family function in gestational diabetes mellitus
		LUO Wen-juan;YUAN Hua-xiang;WU Li
		ObjectiveTo discuss the correlation of blood glucose control with humanistic care and family function in gestational diabetes mellitus.Methods120 patients of gestational diabetes mellitus were selected in our hospital from June 2015 to December 2015.The family function was assessed by scale and the control of blood sugar level in different family functions was compared.The patients were used with humanistic nursing measures,and the effect of blood glucose control before and after nursing was observed and compared.ResultsIn this group,72 patients had better family functioning and 48 patients had poor family functioning.The pre prandial blood glucose,postprandial 2 h blood glucose and glycosylated hemoglobin levels of well functioning family patients were significantly lower than those of patients with poor family function,with statistical significance (P＜0.05).Meanwhile,the postprandial blood glucose,postprandial 2 h blood glucose and glycosylated hemoglobin after the humanized nursing were significantly better than those before nursing,with statistical significance(P＜0.05).ConclusionThe family function of gestational diabetes mellitus has closely related with blood glucose control,and the implementation of humanized nursing mode can improve the blood glucose control effect,and has good application value.
		2017 Vol. 24 (32): 174-176 [Abstract] ( 159 ) HTML (33 KB) PDF (0 KB) ( 66 )

	177	Effects of nursing intervention with seed-embedding at otopoints and acupoint application for relieving pain after surgery for proctorectal diseases
		JIANG Ling-fang
		ObjectiveTo explore the application value of nursing intervention with seed-embedding at otopoints and acupoint application for relieving pain after surgery for proctorectal diseases.Methods86 patients who received surgical treatment for proctorectal diseases in our hospital from January 2015 to February 2017 were included in the study,and were assigned,using random number table,to the control group including 43 patients to receive conventional care,or the observation group including 43 patients to receive conventional care combined with nursing intervention with seed-embedding at otopoints and acupoint application,both for a treatment course of 7 days.The changes in pain before and after nursing care were compared between the two groups,and the two groups were compared for any differences in satisfaction with nursing care and clinical efficacy.ResultsAfter nursing care,there were improvements in VAS score in both groups,and the improvement was greater in the observation group,with statistically significant difference(P＜0.05);the overall satisfaction rate was higher in the observation group(95.35%)than in the control group(76.74%),with statistically significant differences(P＜0.05);the total effective rate was higher in the observation group(97.67%)than in the control group(81.40%)(χ2＝6.081,P＜0.05).ConclusionNursing intervention with seed-embedding at otopoints and acupoint application is significant for patients who have underwent surgery for proctorectal diseases,as it could effective relieve pain and improve satisfaction with nursing care,supporting its further clinical application.
		2017 Vol. 24 (32): 177-179 [Abstract] ( 172 ) HTML (34 KB) PDF (0 KB) ( 70 )

	180	Analysis of rational frequency of oral care in patients undergoing mechanical ventilation via oral trachea intubation
		LE Li-hua
		ObjectiveTo study the clinical effect of reasonable frequency of oral nursing in patients undergoing mechanical ventilation via oral trachea intubation.Methods88 cases in our hospital from December 2015 to December 2016 were selected and the digital table method was randomly divided into control group and experiment group,with 44cases in each group.who underwent mechanical ventilation via oral trachea intubation randomly according to the computer table method：control group underwent one time of oral care：while,experiment group underwent more than two times of oral care.The difference in various data between two groups was analyzed after different oral nursing interventions.ResultsThe oral cleanliness good rate of experiment group after symptomatic nursing intervention was higher than that of control group,with statistically significant difference (P＜0.05),the incidence rate of ventilator associated pneumonia and ulcers was lower than that of control group with statistically significant difference(P＜0.05);the bacteria count of pharyngeal specimens of experiment group was significantly higher than that of control group,with statistically significant difference (P＜0.05).However,the difference between the two groups in the incidence of fungal infections was not significant,without statistically significant difference (P＞0.05).ConclusionApplication of oral nursing at reasonable frequency (≥two times)in patients undergoing mechanical ventilation via oral trachea intubation achieves significant effects,improves the frequency of oral care and oral cleanliness and reduces the incidence of ulcers and halitosis,which is worthy of wide application and research.
		2017 Vol. 24 (32): 180-182 [Abstract] ( 176 ) HTML (30 KB) PDF (0 KB) ( 72 )

	183	Investigation the causes and nursing skills of arrhythmia after total lobectomy in patients with lung cancer
		BU Jin-zhi
		ObjectiveTo analyze the causes of arrhythmia after total lobectomy in patients with lung cancer,and put forward relevant nursing countermeasures.Methods68 patients with lung cancer with total lobectomy from March 2015 to March 2017 of our hospital were selected as study objects.Patients were divided into groups according to whether or not there was arrhythmia after the operation.12 patients with arrhythmia after operation were selected as observation group.56 patients without arrhythmia after operation were selected as control group.The related data of two groups were analyzed,and the causes of arrhythmia after operation were analyzed,and the corresponding nursing countermeasures were put forward.ResultsThe reason of arrhythmia after total lobectomy was related with age,smoking history,history of pulmonary function impairment,heart history,operation time,intraoperative blood loss,postoperative hypoxemia,postoperative hemodynamic changes,postoperative mediastinal swing,postoperative severe pain and postoperative constipation (P＜0.05).Logistic regression analysis showed that the independent risk factors of arrhythmia after total lobectomy were aged more than 65 years old,history of pulmonary function impairment,heart history,postoperative hypoxemia and postoperative hemodynamic changes(P＜0.05).ConclusionThe reason is more complicated with arrhythmia after pneumonectomy for lung cancer patients,including age,cardiopulmonary function,type of surgery,intraoperative blood loss.In this regard,strengthen the patients ECG,timely analgesia,timely detection and treatment complications need to take to reduce the incidence of arrhythmia.
		2017 Vol. 24 (32): 183-185 [Abstract] ( 189 ) HTML (28 KB) PDF (0 KB) ( 61 )

	186	Application of Vacuum Sealing Drainage Technology in Orthopedic Surgery Nursing
		LI Run-xiang;JIANG Zhi-li
		ObjectiveTo explore the effect of application of vacuum sealing drainage technology in the nursing care of patients with orthopedic trauma.MethodsAltogether 136 cases of bone trauma patients who were treated in our hospital from March 2015 to March 2017 were selected as the research object and divided into control group and observation group according to the random number table method,with 68 cases in each group.The control group was treated with traditional natural rubber tube drainage combined with routine nursing intervention postoperatively;the observation group was treated with vacuum sealing drainage with the corresponding nursing;the wound curative effect,the number of wound dressing changes,healing time and patients′nursing satisfaction of two groups were compared.ResultsAmong patients in the observation group,the wound was healed in 24 cases,the treatment was markedly effective in 22 cases and effective in 18 cases;the total effective rate was 95.59%,higher than that of control group(80.88%);the number of wound dressing changes and wound healing time of observation group were lower than those of control group,and patients′nursing satisfaction scores of observation group were higher than those of control group,with statistically significant differences(P＜0.05).ConclusionApplication of combination of vacuum sealing drainage technology and appropriate nursing intervention treatment in patients with orthopedic trauma can promote wound healing,reduce the number of wound dressing changes and helps patients′early recovery,which improves patients′nursing satisfaction and is worthy of further promotion and application.
		2017 Vol. 24 (32): 186-188 [Abstract] ( 136 ) HTML (31 KB) PDF (0 KB) ( 52 )

	189	Effect study of MDT collaborative care in patients with acute cholecystitis operation
		OUYANG Mei;LIU Ling;LIU Wen; QIU Qian;XIAO Bing
		ObjectiveTo investigate the effect of MDT collaborative care in patients with acute cholecystitis operation.Methods71 patients with acute cholecystitis treated in our hospital from July 2015 to July 2016 were grouped according to the random comprehensive sequential method.During the perioperative period,patients in the control group(n＝35)were given the routine nursing,while patients in the observation group (n＝36)were given MDT collaborative care.The treatment effect,clinical correlation indexes and nursing satisfaction degree were compared between the two groups.ResultsThe total effective rate of the observation group was 94.4%,and it was significantly higher than that of the control group(71.4%),and the difference was statistically significant(P＜0.05).The wound healing time and hospitalization time in the observation group were significantly shorter than those of the control group,the frequency of dressing change was fewer than that of the control group,the difference was statistically significant(P＜0.05).Nursing satisfaction degree of the observation group was 97.2%80%,and it was significantly higher than that of the control group,the difference was statistically significant(P＜0.05).ConclusionThe effect of MDT collaborative care applied in acute patients with cholecystitis is prominent,and can enhance the treatment effect at the same time,and has a characteristics of shorter hospitalization time and wound healing time,fewer dressing change times and so on,and it is well satisfied and accepted by patients and worthy of clinical promotion.
		2017 Vol. 24 (32): 189-191 [Abstract] ( 145 ) HTML (32 KB) PDF (0 KB) ( 71 )

	192	Study on the effect of kangaroo nursing on pain intervention of BCG vaccination in full-term newborns
		XIAO Yu-juan;ZHANG Shi-bing
		ObjectiveTo investigate the effect of kangaroo nursing intervention on pain degree of full-term newborns during the process of BCG vaccination.Methods100 newborns who were admitted to our hospital from January 2016 to June 2017 were selected as the experimental subjects.All full-term newborns were divided into groups according to the odd and even number method;control group (50 cases):during BCG vaccination,conventional nursing mode was carried out;observation group(50 cases):during BCG vaccination,kangaroo nursing mode was carried out;through NIPS(neonatal pain rating scale),the pain degree during the process of BCG vaccination in newborns was evaluated clinically,and the crying conditions of the two groups of newborns were analyzed.In addition,the blood oxygen saturation levels and heart rate levels were retrospectively analyzed in both groups.ResultsThe pain scores of full-term newborns in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05);the level of heart rate in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05);the level of oxygen saturation in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The duration of neonatal crying in the observation group was shorter than that in the control group,and the difference was statistically significant(P＜0.05).ConclusionDuring the preparation process of BCG vaccination in full-term newborns,the kangaroo nursing model can make a full guarantee for the relief of pain degree and maintenance of physiological balance,thereby enhancing the satisfaction degree of BCG vaccination in newborn's family.
		2017 Vol. 24 (32): 192-194 [Abstract] ( 118 ) HTML (32 KB) PDF (0 KB) ( 75 )

	195	Effect of collaborative nursing model on self care ability and dialysis compliance of hemodialysis patients
		YI Rong-gui
		ObjectiveTo explore the influence of collaborative nursing model on self-care ability and dialysis compliance of hemodialysis patients.Methods120 long-term dialysis patients admitted to our hospital from September 2015 to July 2017 were randomly divided into the observation group of 60 cases and the control group of 60 cases.The observation group was given cooperative nursing mode,while the control group was given routine nursing mode.The scores of self-care ability and the compliance of the two groups before and after the coordinated care were compared.Resultsthe scores of self ability of the observation group after coordination nursing were higher than that of the control group,and the compliance of the observation group after dialysis treatment was better than that of the control group (P＜0.05),the difference was statistically significant.Conclusionthe cooperative nursing model can effectively improve the selfcare ability and the compliance of dialysis treatment,and the clinical effect is remarkable.It is worthy of further promotion.
		2017 Vol. 24 (32): 195-197 [Abstract] ( 166 ) HTML (31 KB) PDF (0 KB) ( 61 )

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